Interaction of L-phenylalanine with carbonyl groups in mixed lipid membranes
Biochim Biophys Acta Biomembr. 2024 Apr 28:184328. doi: 10.1016/j.bbamem.2024.184328. Online ahead of print.ABSTRACTThe interaction of L-Phe with the membrane components, i.e., lipids and proteins, has been discussed in the current literature due to the interest to understand the effect of single amino acids in relation to the formation of amyloid aggregates. In the present work, it is shown that L-Phe interacts with 9:1 DMPC (1,2-dimyristoyl-sn-glycero-3 phosphocholine)/DPPC (1,2-dipalmitoyl-sn-glycero-3 phosphocholine) mixtures but not in the 1:9 one. An important observation is that the interaction disappears when DPPC ...
Source: Biochimica et Biophysica Acta - April 30, 2024 Category: Biochemistry Authors: Mar ía A Brandan Hugo A P érez An íbal Disalvo Mar ía de Los A Frías Source Type: research
The molecular arrangement of ceramides in the unit cell of the long periodicity phase of stratum corneum models shows a high adaptability to different ceramide head group structures
In this study, the impact of the CER head group structure on the lipid arrangement and barrier functionality was investigated using lipid models forming the LPP. The results demonstrate that the positions of CER N-(tetracosanoyl)-sphingosine (CER NS) and CER N-(tetracosanoyl)-phytosphingosine (CER NP), two essentials CER subclasses, are not influenced by the addition of another CER subclass (N-(tetracosanoyl)-dihydrosphingosine (CER NdS), N-(2R-hydroxy-tetracosanoyl)-sphingosine (CER AS) or D-(2R-hydroxy-tetracosanoyl)-phytosphingosine (CER AP)). However, differences are observed in the lipid organization and the hydrogen ...
Source: Biochimica et Biophysica Acta - April 30, 2024 Category: Biochemistry Authors: Andreea N ădăban Gerrit S Gooris Charlotte M Beddoes Robert M Dalgliesh Marc Malfois Bruno Dem é Joke A Bouwstra Source Type: research
Tumor microenvironment and immune response: A gateway to novel therapies in gastrointestinal cancers
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 28;1870(5):167203. doi: 10.1016/j.bbadis.2024.167203. Online ahead of print.NO ABSTRACTPMID:38688415 | DOI:10.1016/j.bbadis.2024.167203 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - April 30, 2024 Category: Biochemistry Authors: Damian Jacenik Source Type: research
Regulation of VEGF gene expression by bisacridine derivative through promoter i-motif for cancer treatment
CONCLUSION: B09 could specifically regulate VEGF gene expression, possibly through interacting with promoter i-motif structure. As a lead compound, B09 could be further developed for innovative anti-cancer agent targeting VEGF.PMID:38685534 | DOI:10.1016/j.bbagen.2024.130631 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - April 30, 2024 Category: Biochemistry Authors: Jing Wang Siyi Wang Jiahui Zhang Dongsheng Ji Zhi-Shu Huang Ding Li Source Type: research
Interaction of L-phenylalanine with carbonyl groups in mixed lipid membranes
Biochim Biophys Acta Biomembr. 2024 Apr 28:184328. doi: 10.1016/j.bbamem.2024.184328. Online ahead of print.ABSTRACTThe interaction of L-Phe with the membrane components, i.e., lipids and proteins, has been discussed in the current literature due to the interest to understand the effect of single amino acids in relation to the formation of amyloid aggregates. In the present work, it is shown that L-Phe interacts with 9:1 DMPC (1,2-dimyristoyl-sn-glycero-3 phosphocholine)/DPPC (1,2-dipalmitoyl-sn-glycero-3 phosphocholine) mixtures but not in the 1:9 one. An important observation is that the interaction disappears when DPPC ...
Source: Biochimica et Biophysica Acta - April 30, 2024 Category: Biochemistry Authors: Mar ía A Brandan Hugo A P érez An íbal Disalvo Mar ía de Los A Frías Source Type: research
The molecular arrangement of ceramides in the unit cell of the long periodicity phase of stratum corneum models shows a high adaptability to different ceramide head group structures
In this study, the impact of the CER head group structure on the lipid arrangement and barrier functionality was investigated using lipid models forming the LPP. The results demonstrate that the positions of CER N-(tetracosanoyl)-sphingosine (CER NS) and CER N-(tetracosanoyl)-phytosphingosine (CER NP), two essentials CER subclasses, are not influenced by the addition of another CER subclass (N-(tetracosanoyl)-dihydrosphingosine (CER NdS), N-(2R-hydroxy-tetracosanoyl)-sphingosine (CER AS) or D-(2R-hydroxy-tetracosanoyl)-phytosphingosine (CER AP)). However, differences are observed in the lipid organization and the hydrogen ...
Source: Biochimica et Biophysica Acta - April 30, 2024 Category: Biochemistry Authors: Andreea N ădăban Gerrit S Gooris Charlotte M Beddoes Robert M Dalgliesh Marc Malfois Bruno Dem é Joke A Bouwstra Source Type: research
Tumor microenvironment and immune response: A gateway to novel therapies in gastrointestinal cancers
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 28:167203. doi: 10.1016/j.bbadis.2024.167203. Online ahead of print.NO ABSTRACTPMID:38688415 | DOI:10.1016/j.bbadis.2024.167203 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - April 30, 2024 Category: Biochemistry Authors: Damian Jacenik Source Type: research
Regulation of VEGF gene expression by bisacridine derivative through promoter i-motif for cancer treatment
CONCLUSION: B09 could specifically regulate VEGF gene expression, possibly through interacting with promoter i-motif structure. As a lead compound, B09 could be further developed for innovative anti-cancer agent targeting VEGF.PMID:38685534 | DOI:10.1016/j.bbagen.2024.130631 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - April 30, 2024 Category: Biochemistry Authors: Jing Wang Siyi Wang Jiahui Zhang Dongsheng Ji Zhi-Shu Huang Ding Li Source Type: research
Differential accumulation of human β-amyloid and tau from enriched extracts in neuronal and endothelial cells
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 26:167204. doi: 10.1016/j.bbadis.2024.167204. Online ahead of print.ABSTRACTWhile Aβ and Tau cellular distribution has been largely studied, the comparative internalization and subcellular accumulation of Tau and Aβ isolated from human brain extracts in endothelial and neuronal cells has not yet been unveiled. We have previously demonstrated that controlled enrichment of Aβ from human brain extracts constitutes a valuable tool to monitor cellular internalization in vitro and in vivo. Herein, we establish an alternative method to strongly enrich Aβ and Tau aggregates from hum...
Source: Biochimica et Biophysica Acta - April 28, 2024 Category: Biochemistry Authors: Y Rabanal-Ruiz C M Pedrero-Prieto L Sanchez-Rodriguez A Flores-Cuadrado D Saiz-Sanchez J Frontinan-Rubio I Ubeda-Banon M Duran Prado A Martinez-Marcos Juan R Peinado Source Type: research
A promoter-dependent upstream activator augments CFTR expression in diverse epithelial cell types
Biochim Biophys Acta Gene Regul Mech. 2024 Apr 27:195031. doi: 10.1016/j.bbagrm.2024.195031. Online ahead of print.ABSTRACTThe cystic fibrosis transmembrane conductance regulator (CFTR) gene encodes an anion-selective channel found in epithelial cell membranes. Mutations in CFTR cause cystic fibrosis (CF), an inherited disorder that impairs epithelial function in multiple organs. Most men with CF are infertile due to loss of intact genital ducts. Here we investigated a novel epididymis-selective cis-regulatory element (CRE), located within a peak of open chromatin at -9.5 kb 5' to the CFTR gene promoter. Activation of the ...
Source: Biochimica et Biophysica Acta - April 28, 2024 Category: Biochemistry Authors: Giuliana C Coatti Nirbhayaditya Vaghela Pulak Gillurkar Shih-Hsing Leir Ann Harris Source Type: research
Effect of VBIT-4 on the functional activity of isolated mitochondria and cell viability
Biochim Biophys Acta Biomembr. 2024 Apr 26:184329. doi: 10.1016/j.bbamem.2024.184329. Online ahead of print.ABSTRACTVBIT-4 is a new inhibitor of the oligomerization of VDAC proteins of the outer mitochondrial membrane preventing the development of oxidative stress, mitochondrial dysfunction, and cell death in various pathologies. However, as a VDAC inhibitor, VBIT-4 may itself cause mitochondrial dysfunction in healthy cells. The article examines the effect of VBIT-4 on the functional activity of rat liver mitochondria and cell cultures. We have demonstrated that high concentrations of VBIT-4 (15-30 μM) suppressed mitocho...
Source: Biochimica et Biophysica Acta - April 28, 2024 Category: Biochemistry Authors: Konstantin N Belosludtsev Anna I Ilzorkina Lyudmila A Matveeva Alexander V Chulkov Alena A Semenova Mikhail V Dubinin Natalia V Belosludtseva Source Type: research
Insights into short chain polyethylene penetration of phospholipid bilayers via atomistic molecular dynamics simulations
In this study, we leverage all-atom MD simulations to delve into the interactions between lipid bilayers and polyethylene (PETH) chains of varying lengths. The investigation spans diverse lipid bilayer compositions-ranging from pure POPC to POPC:DPPC mixtures-revealing how PETH accommodates itself, adopts extended conformations, and influences membrane structure and ordering. Significantly, while longer PETH chains demonstrate limited passive diffusion, their potential to penetrate bilayers over extended timescales emerges as a significant revelation. Overall, this research significantly advances our comprehension of NP-me...
Source: Biochimica et Biophysica Acta - April 28, 2024 Category: Biochemistry Authors: Franciszek W łodek Waldemar Kulig Anna Stachowicz-Ku śnierz Source Type: research
Processes and mechanisms underlying burst of giant unilamellar vesicles induced by antimicrobial peptides and compounds
Biochim Biophys Acta Biomembr. 2024 Apr 26:184330. doi: 10.1016/j.bbamem.2024.184330. Online ahead of print.ABSTRACTTo clarify the damage of lipid bilayer region in bacterial cell membrane caused by antimicrobial peptides (AMPs) and antimicrobial compounds (AMCs) to cell membranes, their interactions with giant unilamellar vesicles (GUVs) of various lipid compositions have been examined. The findings revealed two main causes for the leakage: nanopore formation in the membrane and burst of GUVs. Although GUV burst has been explained previously based on the carpet model, the supporting evidence is limited. In this review, to...
Source: Biochimica et Biophysica Acta - April 28, 2024 Category: Biochemistry Authors: Md Masum Billah Marzuk Ahmed Md Zahidul Islam Masahito Yamazaki Source Type: research
Adipose tissue rearrangement in cancer cachexia: The involvement of β3-adrenergic receptor associated pathways
Biochim Biophys Acta Rev Cancer. 2024 Apr 26:189103. doi: 10.1016/j.bbcan.2024.189103. Online ahead of print.ABSTRACTCancer-associated cachexia (CAC) is a complex multiple organ syndrome that significantly contributes to reduced quality of life and increased mortality among many cancer patients. Its multifactorial nature makes its early diagnosis and effective therapeutic interventions challenging. Adipose tissue is particularly impacted by cachexia, typically through increased lipolysis, browning and thermogenesis, mainly at the onset of the disease. These processes lead to depletion of fat mass and contribute to the dysf...
Source: Biochimica et Biophysica Acta - April 28, 2024 Category: Biochemistry Authors: In ês N R Mota Setareh Satari In ês Soares Marques Joana M O Santos Rui Medeiros Source Type: research
Vascular inflammation and biogenesis of lipid droplets; what is the link?
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 25:167201. doi: 10.1016/j.bbadis.2024.167201. Online ahead of print.NO ABSTRACTPMID:38677485 | DOI:10.1016/j.bbadis.2024.167201 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - April 27, 2024 Category: Biochemistry Authors: Natalia Chorazy Kamila Wojnar-Lason Magdalena Sternak Marta Z Pacia Source Type: research
