Calcium signaling induces partial EMT and renal fibrosis in a Wnt4 < sup > mCherry < /sup > knock-in mouse model
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 21:167180. doi: 10.1016/j.bbadis.2024.167180. Online ahead of print.ABSTRACTThe renal tubular epithelial cells (TEC) have a strong capacity for repair after acute injury, but when this mechanism becomes uncontrollable, it leads to chronic kidney diseases (CKD). Indeed, in progress toward CKDs, the TECs may dedifferentiate, undergo epithelial-to-mesenchyme transition (EMT), and promote inflammation and fibrosis. Given the critical role of Wnt4 signaling in kidney ontogenesis, we addressed whether changes in this signaling are connected to renal inflammation and fibrosis by taking...
Source: Biochimica et Biophysica Acta - April 23, 2024 Category: Biochemistry Authors: Florence Naillat Ganga Deshar Anni Hankkila Aleksandra Rak-Raszewska Abhishek Sharma Renata Prunskaite-Hyyrylainen Antti Railo Jingdong Shan Seppo J Vainio Source Type: research
Endocannabinoid remodeling in murine cachexic muscle associates with catabolic and metabolic regulation
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 21;1870(5):167179. doi: 10.1016/j.bbadis.2024.167179. Online ahead of print.ABSTRACTMuscle degeneration is a common feature in cancer cachexia that cannot be reversed. Recent advances show that the endocannabinoid system, and more particularly cannabinoid receptor 1 (CB1), regulates muscle processes, including metabolism, anabolism and regenerative capacity. However, it is unclear whether muscle endocannabinoids, their receptors and enzymes are responsive to cachexia and exercise. Therefore, this study investigated whether cachexia and exercise affected muscle endocannabinoid si...
Source: Biochimica et Biophysica Acta - April 23, 2024 Category: Biochemistry Authors: Sebastiaan Dalle Charlotte Hiroux Katrien Koppo Source Type: research
LAGE3 promotes angiogenesis on hepatocellular carcinoma by stabilizing VEGFA mRNA
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 21;1870(5):167196. doi: 10.1016/j.bbadis.2024.167196. Online ahead of print.ABSTRACTRNA modification plays important roles in various physiological and pathological process. LAGE3 is a component of EKC/KEOPS complex, which is probably involved in the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs, but its exact role in HCC is less studied. Our study reveals that LAGE3 exhibits upregulated expression in HCC compared with normal hepatocellular tissue. High expression of LAGE3 promotes hepatocellular cell proliferation and migration. Further i...
Source: Biochimica et Biophysica Acta - April 23, 2024 Category: Biochemistry Authors: Zhuangzhi Cong Huan Zhao Shuyu Zhang Tiangeng You Yanting Xie Source Type: research
Rhythm gene PER1 mediates ferroptosis and lipid metabolism through SREBF2/ALOX15 axis in polycystic ovary syndrome
CONCLUSION: This study demonstrates that the rhythm gene PER1 promotes ferroptosis and dysfunctional lipid metabolism in granulosa cells in PCOS by inhibiting SREBF2/ALOX15 signaling.PMID:38653359 | DOI:10.1016/j.bbadis.2024.167182 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - April 23, 2024 Category: Biochemistry Authors: Yuanyuan Chen Zhaohua Liu Hongmei Chen Yi Wen Lang Fan Man Luo Source Type: research
Mechano-sensor Piezo1 inhibits glucagon production in pancreatic α-cells
CONCLUSION: Our study uncovers the regulatory role of the Piezo1 ion channel in α cells. Piezo1 influences glucagon production by affecting mTOR signaling pathway.PMID:38653360 | DOI:10.1016/j.bbadis.2024.167185 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - April 23, 2024 Category: Biochemistry Authors: Wenying Guo Luyang Gao Haocong Mo Handan Deng Yawen Zhao Geyang Xu Source Type: research
Decorin suppresses stemness and migration potential of malignant peripheral nerve sheath tumor through inhibiting epidermal growth factor receptor signaling
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 21:167181. doi: 10.1016/j.bbadis.2024.167181. Online ahead of print.ABSTRACTCancer stem cells (CSCs) play pivotal roles in the growth, invasion, metastasis, chemo-resistance in malignant peripheral nerve sheath tumor (MPNST). The current characterization of CSCs in MPNST is not complete. Decorin is a critical regulator of microenvironment, but its expression and function in CSCs of MPNST has not been studied. In the current study, Decorin levels and its relationship with lung and liver metastasis were determined in clinical specimens. Decorin expression in CD133-positive or CD44...
Source: Biochimica et Biophysica Acta - April 23, 2024 Category: Biochemistry Authors: Xiaotian Jia Lin Chen Cong Yu Source Type: research
Effects of stand-alone polar residue on membrane protein stability and structure
Biochim Biophys Acta Biomembr. 2024 Apr 21:184325. doi: 10.1016/j.bbamem.2024.184325. Online ahead of print.ABSTRACTHelical membrane proteins generally have a hydrophobic nature, with apolar side chains comprising the majority of the transmembrane (TM) helices. However, whenever polar side chains are present in the TM domain, they often exert a crucial role in structural interactions with other polar residues, such as TM helix associations and oligomerization. Moreover, polar residues in the TM region also often participate in protein functions, such as the Schiff base bonding between Lys residues and retinal in rhodopsin-...
Source: Biochimica et Biophysica Acta - April 23, 2024 Category: Biochemistry Authors: Yu-Chu Chang Zheng Cao Wai-Ting Chen Wei-Chun Huang Source Type: research
Molecular biology and novel therapeutics for IDH mutant gliomas: The new era of IDH inhibitors
Biochim Biophys Acta Rev Cancer. 2024 Apr 21:189102. doi: 10.1016/j.bbcan.2024.189102. Online ahead of print.ABSTRACTGliomas with Isocitrate dehydrogenase (IDH) mutation represent a discrete category of primary brain tumors with distinct and unique characteristics, behaviors, and clinical disease outcomes. IDH mutations lead to aberrant high-level production of the oncometabolite D-2-hydroxyglutarate (D-2HG), which act as a competitive inhibitor of enzymes regulating epigenetics, signaling pathways, metabolism, and various other processes. This review summarizes the significance of IDH mutations, resulting upregulation of ...
Source: Biochimica et Biophysica Acta - April 23, 2024 Category: Biochemistry Authors: Yosuke Kitagawa Ami Kobayashi Daniel P Cahill Hiroaki Wakimoto Shota Tanaka Source Type: research
Exercised-enriched blood plasma rescues hippocampal impairments and cognitive deficits in an Alzheimer's disease model
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 21:167197. doi: 10.1016/j.bbadis.2024.167197. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is a progressive neurodegenerative disorder, and moderate exercise holds promise in ameliorating the ongoing neurodegeneration and cognitive decline. Here, we investigated whether exercise-enriched blood plasm could yield a beneficial therapeutic effect on AD pathologies and cognitive decline in transgenic AD (P301S) mice. In this investigation, a cohort of 2-month-old C57BL/6 mice were granted continuous access to either a running wheel or a fixed wheel for 6 weeks. After that, ...
Source: Biochimica et Biophysica Acta - April 23, 2024 Category: Biochemistry Authors: Tiantian Huang Xiao-Kang Gong Zheng Liang Rong Yang Liangwei Wu Chaoqing Yang Mengjuan Wu Xiao-Chuan Wang Xi-Ji Shu Jian Bao Source Type: research
miR-519a-3p, found to regulate cellular prion protein during Alzheimer's disease pathogenesis, as a biomarker of asymptomatic stages
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 21:167187. doi: 10.1016/j.bbadis.2024.167187. Online ahead of print.ABSTRACTClinical relevance of miRNAs as biomarkers is growing due to their stability and detection in biofluids. In this, diagnosis at asymptomatic stages of Alzheimer's disease (AD) remains a challenge since it can only be made at autopsy according to Braak NFT staging. Achieving the objective of detecting AD at early stages would allow possible therapies to be addressed before the onset of cognitive impairment. Many studies have determined that the expression pattern of some miRNAs is dysregulated in AD patien...
Source: Biochimica et Biophysica Acta - April 23, 2024 Category: Biochemistry Authors: Dayaneth J ácome Tiziana Cotrufo Pol Andr és-Benito Laia Lid ón Eul àlia Martí Isidre Ferrer Jos é Antonio Del Río Rosalina Gav ín Source Type: research
Therapeutic benefits of central LH receptor agonism in the APP/PS1 AD model involve trophic and immune regulation and reproductive status dependent
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 21:167165. doi: 10.1016/j.bbadis.2024.167165. Online ahead of print.ABSTRACTThe mechanisms that underly reproductive hormone effects on cognition, neuronal plasticity, and AD risk, particularly in relation to gonadotropin LH receptor (LHCGR) signaling, remain poorly understood. To address this knowledge gap and clarify the impact of circulating steroid hormones the therapeutic effects of CNS LHCGR activation, we delivered the LHCGR agonist human chorionic gonadotropin (hCG) intracerebroventricularly (ICV) and evaluated functional, structural, plasticity-related signaling cascade...
Source: Biochimica et Biophysica Acta - April 23, 2024 Category: Biochemistry Authors: Megan Mey Sabina Bhatta Sneha Suresh Luis Montero Labrador Helen Piontkivska Gemma Casadesus Source Type: research
Calcium signaling induces partial EMT and renal fibrosis in a Wnt4 < sup > mCherry < /sup > knock-in mouse model
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 21:167180. doi: 10.1016/j.bbadis.2024.167180. Online ahead of print.ABSTRACTThe renal tubular epithelial cells (TEC) have a strong capacity for repair after acute injury, but when this mechanism becomes uncontrollable, it leads to chronic kidney diseases (CKD). Indeed, in progress toward CKDs, the TECs may dedifferentiate, undergo epithelial-to-mesenchyme transition (EMT), and promote inflammation and fibrosis. Given the critical role of Wnt4 signaling in kidney ontogenesis, we addressed whether changes in this signaling are connected to renal inflammation and fibrosis by taking...
Source: Biochimica et Biophysica Acta - April 23, 2024 Category: Biochemistry Authors: Florence Naillat Ganga Deshar Anni Hankkila Aleksandra Rak-Raszewska Abhishek Sharma Renata Prunskaite-Hyyrylainen Antti Railo Jingdong Shan Seppo J Vainio Source Type: research
Endocannabinoid remodeling in murine cachexic muscle associates with catabolic and metabolic regulation
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 21:167179. doi: 10.1016/j.bbadis.2024.167179. Online ahead of print.ABSTRACTMuscle degeneration is a common feature in cancer cachexia that cannot be reversed. Recent advances show that the endocannabinoid system, and more particularly cannabinoid receptor 1 (CB1), regulates muscle processes, including metabolism, anabolism and regenerative capacity. However, it is unclear whether muscle endocannabinoids, their receptors and enzymes are responsive to cachexia and exercise. Therefore, this study investigated whether cachexia and exercise affected muscle endocannabinoid signaling,...
Source: Biochimica et Biophysica Acta - April 23, 2024 Category: Biochemistry Authors: Sebastiaan Dalle Charlotte Hiroux Katrien Koppo Source Type: research
LAGE3 promotes angiogenesis on hepatocellular carcinoma by stabilizing VEGFA mRNA
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 21:167196. doi: 10.1016/j.bbadis.2024.167196. Online ahead of print.ABSTRACTRNA modification plays important roles in various physiological and pathological process. LAGE3 is a component of EKC/KEOPS complex, which is probably involved in the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs, but its exact role in HCC is less studied. Our study reveals that LAGE3 exhibits upregulated expression in HCC compared with normal hepatocellular tissue. High expression of LAGE3 promotes hepatocellular cell proliferation and migration. Further investiga...
Source: Biochimica et Biophysica Acta - April 23, 2024 Category: Biochemistry Authors: Zhuangzhi Cong Huan Zhao Shuyu Zhang Tiangeng You Yanting Xie Source Type: research
Rhythm gene PER1 mediates ferroptosis and lipid metabolism through SREBF2/ALOX15 axis in polycystic ovary syndrome
CONCLUSION: This study demonstrates that the rhythm gene PER1 promotes ferroptosis and dysfunctional lipid metabolism in granulosa cells in PCOS by inhibiting SREBF2/ALOX15 signaling.PMID:38653359 | DOI:10.1016/j.bbadis.2024.167182 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - April 23, 2024 Category: Biochemistry Authors: Yuanyuan Chen Zhaohua Liu Hongmei Chen Yi Wen Lang Fan Man Luo Source Type: research
