Epigenetic arsenal for stress mitigation in plants
Biochim Biophys Acta Gen Subj. 2024 Apr 16;1868(7):130620. doi: 10.1016/j.bbagen.2024.130620. Online ahead of print.ABSTRACTPlant's ability to perceive, respond to, and ultimately adapt to various stressors is a testament to their remarkable resilience. In response to stresses, plants activate a complex array of molecular and physiological mechanisms. These include the rapid activation of stress-responsive genes, the manufacturing of protective compounds, modulation of cellular processes and alterations in their growth and development patterns to enhance their chances of survival. Epigenetic mechanisms play a pivotal role ...
Source: Biochimica et Biophysica Acta - April 18, 2024 Category: Biochemistry Authors: Aishwarya Ashok Gaude Roxiette Heromina Siqueira Savia Bernadette Botelho Siddhi Kashinath Jalmi Source Type: research
The essential link: How STAT3 connects tumor metabolism to immunity
Biochim Biophys Acta Gene Regul Mech. 2024 Apr 16;1867(2):195028. doi: 10.1016/j.bbagrm.2024.195028. Online ahead of print.ABSTRACTImmunotherapy is a promising and long-lasting tumor treatment method, but it is challenged by the complex metabolism of tumors. To optimize immunotherapy, it is essential to further investigate the key proteins that regulate tumor metabolism and immune response. STAT3 plays a crucial role in regulating tumor dynamic metabolism and affecting immune cell function by responding to various cytokines and growth factors, which can be used as a potential target for immunotherapy. This review focuses o...
Source: Biochimica et Biophysica Acta - April 18, 2024 Category: Biochemistry Authors: Shu Zhong Jingjing Tong Source Type: research
Human oligodendrocyte-like cell differentiation is promoted by TSPO-mediated endogenous steroidogenesis
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 15:167174. doi: 10.1016/j.bbadis.2024.167174. Online ahead of print.ABSTRACTMature oligodendrocytes (OLs) arise from oligodendrocyte precursor cells that, in case of demyelination, are recruited at the lesion site to remyelinate the axons and therefore restore the transmission of nerve impulses. It has been widely documented that exogenously administered steroid molecules are potent inducers of myelination. However, little is known about how neurosteroids produced de novo by OLs can impact this process. Here, we employed a human OL precursor cell line to investigate the role of ...
Source: Biochimica et Biophysica Acta - April 17, 2024 Category: Biochemistry Authors: Chiara Tremolanti Elisa Angeloni Eleonora Da Pozzo Lorenzo Germelli Chiara Giacomelli Eduardo Scalzi Sabrina Taliani Federico Da Settimo Ayiko é-Guy Mensah-Nyagan Claudia Martini Barbara Costa Source Type: research
Urotensin II receptor deficiency ameliorates ligation-induced carotid intimal hyperplasia partially through the RhoA-YAP1 pathway
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 15;1870(5):167170. doi: 10.1016/j.bbadis.2024.167170. Online ahead of print.ABSTRACTIntimal hyperplasia (IH) is a common pathological feature of vascular proliferative diseases, such as atherosclerosis and restenosis after angioplasty. Urotensin II (UII) and its receptor (UTR) are widely expressed in cardiovascular tissues. However, it remains unclear whether the UII/UTR system is involved in IH. Right unilateral common carotid artery ligation was performed and maintained for 21 days to induce IH in UTR knockout (UTR-/-) and wild-type (WT) mice. Histological analysis revealed th...
Source: Biochimica et Biophysica Acta - April 17, 2024 Category: Biochemistry Authors: Panpan Wei Kangli Tian Haole Liu Kexin Li Naqash Alam Daxin Cheng Meng Li Xue He Jia Guo Rong Wang Weirong Wang Liang Bai Enqi Liu Baohui Xu Yankui Li Sihai Zhao Source Type: research
Mitochondrial calcium signaling in non-neuronal cells: Implications for Alzheimer's disease pathogenesis
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 15;1870(5):167169. doi: 10.1016/j.bbadis.2024.167169. Online ahead of print.ABSTRACTMitochondrial dysregulation is pivotal in Alzheimer's disease (AD) pathogenesis. Calcium governs vital mitochondrial processes impacting energy conversion, oxidative stress, and cell death signaling. Disruptions in mitochondrial calcium (mCa2+) handling induce calcium overload and trigger the opening of mitochondrial permeability transition pore, ensuing energy deprivation and resulting in AD-related neuronal cell death. However, the role of mCa2+ in non-neuronal cells (microglia, astrocytes, oli...
Source: Biochimica et Biophysica Acta - April 17, 2024 Category: Biochemistry Authors: Darpan Raghav Shatakshi Shukla Pooja Jadiya Source Type: research
The paradox of fatty-acid β-oxidation in muscle insulin resistance: Metabolic control and muscle heterogeneity
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 15:167172. doi: 10.1016/j.bbadis.2024.167172. Online ahead of print.ABSTRACTThe skeletal muscle is a metabolically heterogeneous tissue that plays a key role in maintaining whole-body glucose homeostasis. It is well known that muscle insulin resistance (IR) precedes the development of type 2 diabetes. There is a consensus that the accumulation of specific lipid species in the tissue can drive IR. However, the role of the mitochondrial fatty-acid β-oxidation in IR and, consequently, in the control of glucose uptake remains paradoxical: interventions that either inhibit or activa...
Source: Biochimica et Biophysica Acta - April 17, 2024 Category: Biochemistry Authors: Marcel A Vieira-Lara Barbara M Bakker Source Type: research
Caveolin-2 palmitoylation turnover facilitates insulin receptor substrate-1-directed lipid metabolism by insulin receptor tyrosine kinase
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 15:167173. doi: 10.1016/j.bbadis.2024.167173. Online ahead of print.ABSTRACTHere, we show that insulin induces palmitoylation turnover of Caveolin-2 (Cav-2) in adipocytes. Acyl protein thioesterases-1 (APT1) catalyzes Cav-2 depalmitoylation, and zinc finger DHHC domain-containing protein palmitoyltransferase 21 (ZDHHC21) repalmitoylation of the depalmitoylated Cav-2 for the turnover, thereby controlling insulin receptor (IR)-Cav-2-insulin receptor substrate-1 (IRS-1)-Akt-driven signaling. Insulin-induced palmitoylation turnover of Cav-2 facilitated glucose uptake and fat storage...
Source: Biochimica et Biophysica Acta - April 17, 2024 Category: Biochemistry Authors: Moonjeong Choi Jaewoong Lee Kyuho Jeong Yunbae Pak Source Type: research
High phosphate and calcium induce osteoblastic phenotype switching and calcification of corneal epithelial cells in a Runx2-dependent and synergistic manner; a possible mechanism of chronic kidney disease-associated corneal calcification
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 15:167171. doi: 10.1016/j.bbadis.2024.167171. Online ahead of print.ABSTRACTPatients with advanced chronic kidney disease (CKD) have elevated circulating calcium × phosphate product levels and exhibit soft tissue calcification. Besides the cardiovascular system, calcification is commonly observed in the cornea in CKD patients on hemodialysis. Cardiovascular calcification is a cell-mediated, highly regulated process, and we hypothesized that a similar regulatory mechanism is implicated in corneal calcification with the involvement of corneal epithelial cells (CECs). We establish...
Source: Biochimica et Biophysica Acta - April 17, 2024 Category: Biochemistry Authors: Haneen Ababneh Andrea T óth Gr éta Lente Enik ő Balogh D ávid Máté Csiki B éla Nagy Árpád Szöőr Vikt ória Jeney Source Type: research
Fe/S proteins in microbial sulfur oxidation
This article is part of a Special Issue entitled: Biogenesis and Function of Fe/S proteins.PMID:38631440 | DOI:10.1016/j.bbamcr.2024.119732 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - April 17, 2024 Category: Biochemistry Authors: Carolin K ümpel Martina Grosser Tomohisa Sebastian Tanabe Christiane Dahl Source Type: research
When iron and sulfur met on an anoxic planet and eventually made clusters essential for life
Biochim Biophys Acta Mol Cell Res. 2024 Apr 15:119730. doi: 10.1016/j.bbamcr.2024.119730. Online ahead of print.ABSTRACT[FeS] clusters are co-factors that are essential for life and are synthesized by dedicated multiprotein cellular machineries. In this review, we present the current scenario for the emergence and the diversification of the [FeS] cluster biosynthesis machineries. In addition to well-known NIF, ISC and SUF machineries, two alternative minimal systems, SMS, and MIS, were recently identified. Taxonomic distribution and phylogeny analyses indicate that SMS and MIS were present in the Last Universal Common Ance...
Source: Biochimica et Biophysica Acta - April 17, 2024 Category: Biochemistry Authors: Pierre Simon Garcia Simonetta Gribaldo Fr édéric Barras Source Type: research
Shared functions of FeS cluster assembly and Moco biosynthesis
Biochim Biophys Acta Mol Cell Res. 2024 Apr 15:119731. doi: 10.1016/j.bbamcr.2024.119731. Online ahead of print.ABSTRACTMolybdenum cofactor (Moco) biosynthesis is a complex process that involves the coordinated function of several proteins. In the recent years it has become evident that the availability of FeS clusters play an important role for the biosynthesis of Moco. First, the MoaA protein binds two [4Fe-4S] clusters per monomer. Second, the expression of the moaABCDE and moeAB operons is regulated by FNR, which senses the availability of oxygen via a functional [4Fe4S] cluster. Finally, the conversion of cyclic pyran...
Source: Biochimica et Biophysica Acta - April 17, 2024 Category: Biochemistry Authors: Muhammad Abrar Hasnat Silke Leimk ühler Source Type: research
Human oligodendrocyte-like cell differentiation is promoted by TSPO-mediated endogenous steroidogenesis
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 15:167174. doi: 10.1016/j.bbadis.2024.167174. Online ahead of print.ABSTRACTMature oligodendrocytes (OLs) arise from oligodendrocyte precursor cells that, in case of demyelination, are recruited at the lesion site to remyelinate the axons and therefore restore the transmission of nerve impulses. It has been widely documented that exogenously administered steroid molecules are potent inducers of myelination. However, little is known about how neurosteroids produced de novo by OLs can impact this process. Here, we employed a human OL precursor cell line to investigate the role of ...
Source: Biochimica et Biophysica Acta - April 17, 2024 Category: Biochemistry Authors: Chiara Tremolanti Elisa Angeloni Eleonora Da Pozzo Lorenzo Germelli Chiara Giacomelli Eduardo Scalzi Sabrina Taliani Federico Da Settimo Ayiko é-Guy Mensah-Nyagan Claudia Martini Barbara Costa Source Type: research
Urotensin II receptor deficiency ameliorates ligation-induced carotid intimal hyperplasia partially through the RhoA-YAP1 pathway
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 15:167170. doi: 10.1016/j.bbadis.2024.167170. Online ahead of print.ABSTRACTIntimal hyperplasia (IH) is a common pathological feature of vascular proliferative diseases, such as atherosclerosis and restenosis after angioplasty. Urotensin II (UII) and its receptor (UTR) are widely expressed in cardiovascular tissues. However, it remains unclear whether the UII/UTR system is involved in IH. Right unilateral common carotid artery ligation was performed and maintained for 21 days to induce IH in UTR knockout (UTR-/-) and wild-type (WT) mice. Histological analysis revealed that compa...
Source: Biochimica et Biophysica Acta - April 17, 2024 Category: Biochemistry Authors: Panpan Wei Kangli Tian Haole Liu Kexin Li Naqash Alam Daxin Cheng Meng Li Xue He Jia Guo Rong Wang Weirong Wang Liang Bai Enqi Liu Baohui Xu Yankui Li Sihai Zhao Source Type: research
Mitochondrial calcium signaling in non-neuronal cells: Implications for Alzheimer's disease pathogenesis
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 15:167169. doi: 10.1016/j.bbadis.2024.167169. Online ahead of print.ABSTRACTMitochondrial dysregulation is pivotal in Alzheimer's disease (AD) pathogenesis. Calcium governs vital mitochondrial processes impacting energy conversion, oxidative stress, and cell death signaling. Disruptions in mitochondrial calcium (mCa2+) handling induce calcium overload and trigger the opening of mitochondrial permeability transition pore, ensuing energy deprivation and resulting in AD-related neuronal cell death. However, the role of mCa2+ in non-neuronal cells (microglia, astrocytes, oligodendro...
Source: Biochimica et Biophysica Acta - April 17, 2024 Category: Biochemistry Authors: Darpan Raghav Shatakshi Shukla Pooja Jadiya Source Type: research
The paradox of fatty-acid β-oxidation in muscle insulin resistance: Metabolic control and muscle heterogeneity
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 15:167172. doi: 10.1016/j.bbadis.2024.167172. Online ahead of print.ABSTRACTThe skeletal muscle is a metabolically heterogeneous tissue that plays a key role in maintaining whole-body glucose homeostasis. It is well known that muscle insulin resistance (IR) precedes the development of type 2 diabetes. There is a consensus that the accumulation of specific lipid species in the tissue can drive IR. However, the role of the mitochondrial fatty-acid β-oxidation in IR and, consequently, in the control of glucose uptake remains paradoxical: interventions that either inhibit or activa...
Source: Biochimica et Biophysica Acta - April 17, 2024 Category: Biochemistry Authors: Marcel A Vieira-Lara Barbara M Bakker Source Type: research
