Nuclear Rac1 controls nuclear architecture and cell migration of glioma cells
Biochim Biophys Acta Gen Subj. 2024 Apr 25:130632. doi: 10.1016/j.bbagen.2024.130632. Online ahead of print.ABSTRACTRac1 (Ras-related C3 botulinum toxin substrate 1) protein has been found in the cell nucleus many years ago, however, its nuclear functions are still poorly characterized but some data suggest its nuclear accumulation in cancers. We investigated nuclear Rac1 in glioma cancer cells nuclei and compared its levels and activity to normal astrocytes, and also characterized the studied cells on various nuclear properties and cell migration patterns. Nuclear Rac1 indeed was found accumulated in glioma cells, but onl...
Source: Biochimica et Biophysica Acta - April 27, 2024 Category: Biochemistry Authors: Nowak Natalia Sas-Nowosielska Hanna Szyma ński Jędrzej Source Type: research
Corrigendum to "Small extracellular vesicles-mediated cellular interactions between tumor cells and tumor-associated macrophages: Implication for immunotherapy" [Biochim. Biophys. Acta (BBA) - Mol. Basis Dis. Volume 1870(2) (2024), 166917 Article Number]
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 26:167160. doi: 10.1016/j.bbadis.2024.167160. Online ahead of print.NO ABSTRACTPMID:38677963 | DOI:10.1016/j.bbadis.2024.167160 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - April 27, 2024 Category: Biochemistry Authors: Liaoran Niu Qi Wang Fan Feng Wanli Yang Zhenyu Xie Gaozan Zheng Wei Zhou Lili Duan Kunli Du Yiding Li Ye Tian Junfeng Chen Qibin Xie Aqiang Fan Hanjun Dan Jinqiang Liu Daiming Fan Liu Hong Jian Zhang Jianyong Zheng Source Type: research
Vascular inflammation and biogenesis of lipid droplets; what is the link?
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 25:167201. doi: 10.1016/j.bbadis.2024.167201. Online ahead of print.NO ABSTRACTPMID:38677485 | DOI:10.1016/j.bbadis.2024.167201 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - April 27, 2024 Category: Biochemistry Authors: Natalia Chorazy Kamila Wojnar-Lason Magdalena Sternak Marta Z Pacia Source Type: research
Nuclear Rac1 controls nuclear architecture and cell migration of glioma cells
Biochim Biophys Acta Gen Subj. 2024 Apr 25:130632. doi: 10.1016/j.bbagen.2024.130632. Online ahead of print.ABSTRACTRac1 (Ras-related C3 botulinum toxin substrate 1) protein has been found in the cell nucleus many years ago, however, its nuclear functions are still poorly characterized but some data suggest its nuclear accumulation in cancers. We investigated nuclear Rac1 in glioma cancer cells nuclei and compared its levels and activity to normal astrocytes, and also characterized the studied cells on various nuclear properties and cell migration patterns. Nuclear Rac1 indeed was found accumulated in glioma cells, but onl...
Source: Biochimica et Biophysica Acta - April 27, 2024 Category: Biochemistry Authors: Nowak Natalia Sas-Nowosielska Hanna Szyma ński Jędrzej Source Type: research
Corrigendum to "Small extracellular vesicles-mediated cellular interactions between tumor cells and tumor-associated macrophages: Implication for immunotherapy" [Biochim. Biophys. Acta (BBA) - Mol. Basis Dis. Volume 1870(2) (2024), 166917 Article Number]
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 26:167160. doi: 10.1016/j.bbadis.2024.167160. Online ahead of print.NO ABSTRACTPMID:38677963 | DOI:10.1016/j.bbadis.2024.167160 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - April 27, 2024 Category: Biochemistry Authors: Liaoran Niu Qi Wang Fan Feng Wanli Yang Zhenyu Xie Gaozan Zheng Wei Zhou Lili Duan Kunli Du Yiding Li Ye Tian Junfeng Chen Qibin Xie Aqiang Fan Hanjun Dan Jinqiang Liu Daiming Fan Liu Hong Jian Zhang Jianyong Zheng Source Type: research
Assessing the martini 3 protein model: A review of its path and potential
Biochim Biophys Acta Proteins Proteom. 2024 Apr 24:141014. doi: 10.1016/j.bbapap.2024.141014. Online ahead of print.ABSTRACTCoarse-grained (CG) protein models have become indispensable tools for studying many biological protein details, from conformational dynamics to the organization of protein macro-complexes, and even the interaction of proteins with other molecules. The Martini force field is one of the most widely used CG models for bio-molecular simulations, partly because of the enormous success of its protein model. With the recent release of a new and improved version of the Martini force field - Martini 3 - a new...
Source: Biochimica et Biophysica Acta - April 26, 2024 Category: Biochemistry Authors: Lu ís Borges-Araújo Gilberto P Pereira Mariana Val ério Paulo C T Souza Source Type: research
A mouse model of autoimmune inner ear disease without endolymphatic hydrops
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 24:167198. doi: 10.1016/j.bbadis.2024.167198. Online ahead of print.ABSTRACTAutoimmune inner ear disease (AIED) is an organ-specific disease characterized by irreversible, prolonged, and progressive hearing and equilibrium dysfunctions. The primary symptoms of AIED include asymmetric sensorineural hearing loss accompanied by vertigo, aural fullness, and tinnitus. AIED is divided into primary and secondary types. Research has been conducted using animal models of rheumatoid arthritis (RA), a cause of secondary AIED. However, current models are insufficient to accurately analyze v...
Source: Biochimica et Biophysica Acta - April 26, 2024 Category: Biochemistry Authors: Shotaro Harada Yoshihisa Koyama Takao Imai Yoshichika Yoshioka Takuya Sumi Hidenori Inohara Shoichi Shimada Source Type: research
CILP2 promotes hypertrophic scar through Snail acetylation by interaction with ACLY
CONCLUSION: CILP2 exerts a vital role in hypertrophic scar formation and might be a detectable biomarker reflecting the progression of hypertrophic scar and a therapeutic target for hypertrophic scar.PMID:38670440 | DOI:10.1016/j.bbadis.2024.167202 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - April 26, 2024 Category: Biochemistry Authors: Jianzhang Wang Juan Du Yuanyong Wang Yajuan Song Junzheng Wu Tong Wang Zhou Yu Baoqiang Song Source Type: research
TAT38 and TAT38 mimics potently inhibit adipogenesis by repressing C/EBP α, PPARγ, Pi-PPARγ, and SREBP1 expression
Biochim Biophys Acta Gene Regul Mech. 2024 Apr 24:195030. doi: 10.1016/j.bbagrm.2024.195030. Online ahead of print.ABSTRACTAntiretroviral therapy-naive people living with HIV possess less fat than people without HIV. Previously, we found that HIV-1 transactivator of transcription (TAT) decreases fat in ob/ob mice. The TAT38 (a.a. 20-57) is important in the inhibition of adipogenesis and contains three functional domains: Cys-ZF domain (a.a. 20-35 TACTNCYCAKCCFQVC), core-domain (a.a. 36-46, FITKALGISYG), and protein transduction domain (PTD)(a.a. 47-57, RAKRRQRRR). Interestingly, the TAT38 region interacts with the Cyclin T...
Source: Biochimica et Biophysica Acta - April 26, 2024 Category: Biochemistry Authors: Sun-Young Park Dongyoon Shin Young So Yoon Sujin Park Seung Soon Im Yeongshin Kim Young-Soo Kim CheolSoo Choi Man-Wook Hur Source Type: research
RBM3 enhances the stability of MEF2C mRNA and modulates blood-brain barrier permeability in AD microenvironment
This study found the reduced RNA binding motif protein 3 (RBM3) expression in brain microvascular endothelial cells (BMECs) incubated with Aβ1-42. This downregulation of RBM3 caused a decrease in the levels of ZO-1 and occludin and increased the permeability of BBB cell model in AD microenvironment. Myocyte enhancer factor 2C (MEF2C) expression was also inhibited in BMECs incubated with Aβ1-42. A decrease in MEF2C expression led to increased permeability of BBB cell model in AD microenvironment and reductions in the levels of ZO-1 and occludin. Further analysis of the underlying mechanism revealed that RBM3 binds to and ...
Source: Biochimica et Biophysica Acta - April 26, 2024 Category: Biochemistry Authors: Ye Ding Meiqing Lin Jirui Wang Xiuli Shang Source Type: research
Assessing the martini 3 protein model: A review of its path and potential
Biochim Biophys Acta Proteins Proteom. 2024 Apr 24:141014. doi: 10.1016/j.bbapap.2024.141014. Online ahead of print.ABSTRACTCoarse-grained (CG) protein models have become indispensable tools for studying many biological protein details, from conformational dynamics to the organization of protein macro-complexes, and even the interaction of proteins with other molecules. The Martini force field is one of the most widely used CG models for bio-molecular simulations, partly because of the enormous success of its protein model. With the recent release of a new and improved version of the Martini force field - Martini 3 - a new...
Source: Biochimica et Biophysica Acta - April 26, 2024 Category: Biochemistry Authors: Lu ís Borges-Araújo Gilberto P Pereira Mariana Val ério Paulo C T Souza Source Type: research
A mouse model of autoimmune inner ear disease without endolymphatic hydrops
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 24:167198. doi: 10.1016/j.bbadis.2024.167198. Online ahead of print.ABSTRACTAutoimmune inner ear disease (AIED) is an organ-specific disease characterized by irreversible, prolonged, and progressive hearing and equilibrium dysfunctions. The primary symptoms of AIED include asymmetric sensorineural hearing loss accompanied by vertigo, aural fullness, and tinnitus. AIED is divided into primary and secondary types. Research has been conducted using animal models of rheumatoid arthritis (RA), a cause of secondary AIED. However, current models are insufficient to accurately analyze v...
Source: Biochimica et Biophysica Acta - April 26, 2024 Category: Biochemistry Authors: Shotaro Harada Yoshihisa Koyama Takao Imai Yoshichika Yoshioka Takuya Sumi Hidenori Inohara Shoichi Shimada Source Type: research
CILP2 promotes hypertrophic scar through Snail acetylation by interaction with ACLY
CONCLUSION: CILP2 exerts a vital role in hypertrophic scar formation and might be a detectable biomarker reflecting the progression of hypertrophic scar and a therapeutic target for hypertrophic scar.PMID:38670440 | DOI:10.1016/j.bbadis.2024.167202 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - April 26, 2024 Category: Biochemistry Authors: Jianzhang Wang Juan Du Yuanyong Wang Yajuan Song Junzheng Wu Tong Wang Zhou Yu Baoqiang Song Source Type: research
TAT38 and TAT38 mimics potently inhibit adipogenesis by repressing C/EBP α, PPARγ, Pi-PPARγ, and SREBP1 expression
Biochim Biophys Acta Gene Regul Mech. 2024 Apr 24:195030. doi: 10.1016/j.bbagrm.2024.195030. Online ahead of print.ABSTRACTAntiretroviral therapy-naive people living with HIV possess less fat than people without HIV. Previously, we found that HIV-1 transactivator of transcription (TAT) decreases fat in ob/ob mice. The TAT38 (a.a. 20-57) is important in the inhibition of adipogenesis and contains three functional domains: Cys-ZF domain (a.a. 20-35 TACTNCYCAKCCFQVC), core-domain (a.a. 36-46, FITKALGISYG), and protein transduction domain (PTD)(a.a. 47-57, RAKRRQRRR). Interestingly, the TAT38 region interacts with the Cyclin T...
Source: Biochimica et Biophysica Acta - April 26, 2024 Category: Biochemistry Authors: Sun-Young Park Dongyoon Shin Young So Yoon Sujin Park Seung Soon Im Yeongshin Kim Young-Soo Kim CheolSoo Choi Man-Wook Hur Source Type: research
RBM3 enhances the stability of MEF2C mRNA and modulates blood-brain barrier permeability in AD microenvironment
This study found the reduced RNA binding motif protein 3 (RBM3) expression in brain microvascular endothelial cells (BMECs) incubated with Aβ1-42. This downregulation of RBM3 caused a decrease in the levels of ZO-1 and occludin and increased the permeability of BBB cell model in AD microenvironment. Myocyte enhancer factor 2C (MEF2C) expression was also inhibited in BMECs incubated with Aβ1-42. A decrease in MEF2C expression led to increased permeability of BBB cell model in AD microenvironment and reductions in the levels of ZO-1 and occludin. Further analysis of the underlying mechanism revealed that RBM3 binds to and ...
Source: Biochimica et Biophysica Acta - April 26, 2024 Category: Biochemistry Authors: Ye Ding Meiqing Lin Jirui Wang Xiuli Shang Source Type: research
