DDIT3/CHOP promotes LPS/ATP-induced pyroptosis in osteoblasts via mitophagy inhibition
Biochim Biophys Acta Mol Cell Res. 2024 Mar 21:119712. doi: 10.1016/j.bbamcr.2024.119712. Online ahead of print.ABSTRACTInflammatory environments can trigger endoplasmic reticulum (ER) stress and lead to pyroptosis in various tissues and cells, including liver, brain, and immune cells. As a key factor of ER stress, DNA damage-inducible transcript 3 (DDIT3)/CCAAT/enhancer-binding protein (C/EBP) homologous protein (CHOP) is upregulated in osteoblasts during inflammatory stimulation. DDIT3/CHOP may therefore regulate osteoblast pyroptosis in inflammatory conditions. During this investigation, we found that lipopolysaccharide...
Source: Biochimica et Biophysica Acta - March 23, 2024 Category: Biochemistry Authors: Zhipeng Dong Beining Yang Meie Jia Chang Yang Shuo Wang Hailin Mu Jiawei Wang Source Type: research
cAMP in budding yeast: Also a messenger for sucrose metabolism?
Biochim Biophys Acta Mol Cell Res. 2024 Mar 21:119706. doi: 10.1016/j.bbamcr.2024.119706. Online ahead of print.ABSTRACTS. cerevisiae (or budding yeast) is an important micro-organism for sucrose-based fermentation in biotechnology. Yet, it is largely unknown how budding yeast adapts to sucrose transitions. Sucrose can only be metabolized when the invertase or the maltose machinery are expressed and we propose that the Gpr1p receptor signals extracellular sucrose availability via the cAMP peak to adapt cells accordingly. A transition to sucrose or glucose gave a transient cAMP peak which was maximally induced for sucrose. ...
Source: Biochimica et Biophysica Acta - March 23, 2024 Category: Biochemistry Authors: Dennis Botman Sineka Kanagasabapathi Mila I Rep Kelly van Rossum Evelina Tutucci Bas Teusink Source Type: research
Recent advances in canonical versus non-canonical Ca < sup > 2+ < /sup > -signaling-related anti-apoptotic Bcl-2 functions and prospects for cancer treatment
Biochim Biophys Acta Mol Cell Res. 2024 Mar 21:119713. doi: 10.1016/j.bbamcr.2024.119713. Online ahead of print.ABSTRACTCell fate is tightly controlled by a continuous balance between cell survival and cell death inducing mechanisms. B-cell lymphoma 2 (Bcl-2)-family members, composed of effectors and regulators, not only control apoptosis at the level of the mitochondria but also by impacting the intracellular Ca2+ homeostasis and dynamics. On the one hand, anti-apoptotic protein Bcl-2, prevents mitochondrial outer membrane permeabilization (MOMP) by scaffolding and neutralizing proapoptotic Bcl-2-family members via its hy...
Source: Biochimica et Biophysica Acta - March 23, 2024 Category: Biochemistry Authors: Claire Cauwelier Ian de Ridder Geert Bultynck Source Type: research
Systemic and strict regulation of the glutathione redox state in mitochondria and cytosol is needed for zebrafish ontogeny
CONCLUSIONS: Mitochondrial and cytosolic GSSG:GSH ratios are almost identical in different organs during zebrafish development indicating that the EhGSH might follow H2O2 levels and rather indirectly affect specific enzymatic activities needed for proper embryogenesis.GENERAL SIGNIFICANCE: Our data confirm that vertebrate embryogenesis depends on strictly regulated redox homeostasis. Disturbance of the GSSG:GSH circuit, e.g. induced by environmental pollution, leads to malformation and death.PMID:38521470 | DOI:10.1016/j.bbagen.2024.130603 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - March 23, 2024 Category: Biochemistry Authors: Kristin Hamre Wuxiao Zhang Maren Hoff Austgulen Eva Mykkeltvedt Peng Yin Marc Berntssen Marit Espe Carsten Berndt Source Type: research
New thiazolidine-2,4-diones as potential anticancer agents and apoptotic inducers targeting VEGFR-2 kinase: Design, synthesis, in silico and in vitro studies
CONCLUSION: Compound 15 has promising anticancer activity targeting VEGFR-2 with significant activity as an apoptosis inducer.PMID:38521471 | DOI:10.1016/j.bbagen.2024.130599 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - March 23, 2024 Category: Biochemistry Authors: Hazem Elkady Hazem A Mahdy Mohammed S Taghour Mohammed A Dahab Alaa Elwan Mohamed Hagras Mona H Hussein Ibrahim M Ibrahim Dalal Z Husein Eslam B Elkaeed Aisha A Alsfouk Ahmed Metwaly Ibrahim Eissa Source Type: research
