Systemic and strict regulation of the glutathione redox state in mitochondria and cytosol is needed for zebrafish ontogeny

CONCLUSIONS: Mitochondrial and cytosolic GSSG:GSH ratios are almost identical in different organs during zebrafish development indicating that the EhGSH might follow H2O2 levels and rather indirectly affect specific enzymatic activities needed for proper embryogenesis.GENERAL SIGNIFICANCE: Our data confirm that vertebrate embryogenesis depends on strictly regulated redox homeostasis. Disturbance of the GSSG:GSH circuit, e.g. induced by environmental pollution, leads to malformation and death.PMID:38521470 | DOI:10.1016/j.bbagen.2024.130603

Source: Biochimica et Biophysica Acta - March 23, 2024 Category: Biochemistry Authors: Kristin Hamre Wuxiao Zhang Maren Hoff Austgulen Eva Mykkeltvedt Peng Yin Marc Berntssen Marit Espe Carsten Berndt Source Type: research