Rabeprazole mitigates obesity-induced chronic inflammation and insulin resistance associated with increased M2-type macrophage polarization
Biochim Biophys Acta Mol Basis Dis. 2024 Mar 31:167142. doi: 10.1016/j.bbadis.2024.167142. Online ahead of print.ABSTRACTMacrophage polarization is closely associated with obesity-induced chronic inflammation and insulin resistance. Proton pump inhibitor Rabeprazole has long been used to treat gastritis and gastric ulcers. However, whether Rabeprazole plays a role in macrophage polarization during obesity is unknown. Here, we show that Rabeprazole suppresses M1-type macrophage-mediated inflammation, leads to increased M2-type macrophages and alters the polarization status from M1 to M2 in vitro. Mechanistically, Rabe-regul...
Source: Biochimica et Biophysica Acta - April 2, 2024 Category: Biochemistry Authors: Yunfang Li Jiayue Hao Xianghui Kong Weiyi Yuan Yingying Shen Zhaoyuan Hui Xinliang Lu Source Type: research
PTPRO inhibition ameliorates spinal cord injury through shifting microglial M1/M2 polarization via the NF- κB/STAT6 signaling pathway
In conclusion, PTPRO inhibition improves spinal cord injury through facilitating M2 microglia polarization via the NF-κB/STAT6 signaling pathway, which is probably controlled by SOX4.PMID:38565385 | DOI:10.1016/j.bbadis.2024.167141 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - April 2, 2024 Category: Biochemistry Authors: Haocong Zhang Liangbi Xiang Hong Yuan Hailong Yu Source Type: research
OTUD1 enhances gastric cancer aggressiveness by deubiquitinating EBV-encoded protein BALF1 to stabilize the apoptosis inhibitor Bcl-2
This study focuses on EBV-encoded BALF1 (BamH1 A fragment leftward reading frame 1), a key apoptosis regulator in EBV-related cancers, whose specific impact on EBVaGC was previously unknown. Our findings indicate that BALF1 overexpression in gastric cancer cells significantly enhances their proliferation, migration, and resistance to chemotherapy-induced apoptosis, confirming BALF1's oncogenic potential. A novel discovery is that BALF1 undergoes degradation via the ubiquitin-proteasome pathway. Through analysis of 69 deubiquitinating enzymes (DUBs), ovarian tumor protease (OTU) domain-containing protein 1 (OTUD1) emerged a...
Source: Biochimica et Biophysica Acta - April 2, 2024 Category: Biochemistry Authors: Hanbin Lin Yuting Han Yuchao Sang Yuecheng Wu Mengyue Tian Xintan Chen Xu Lin Xinjian Lin Source Type: research
Extracellular CIRP co-stimulated T cells through IL6R/STAT3 in pediatric IgA vasculitis
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 1:167151. doi: 10.1016/j.bbadis.2024.167151. Online ahead of print.ABSTRACTImmunoglobulin A vasculitis (IgAV) is the most common vasculitis of childhood. Disordered immune responses play important roles in its pathogenesis, but the comprehensive immune profile of the disease and the underlying mechanisms are still largely unknown. Here we found a potential disease biomarker cold inducible RNA binding protein (CIRP) in our pediatric IgAV cohort. Serum CIRP level in these patients were elevated and positively correlated with the increased early memory (CD45RA+CD62L+CD95+) T cells ...
Source: Biochimica et Biophysica Acta - April 2, 2024 Category: Biochemistry Authors: Hong Lei Dan Li Mingyue Duan Yuanyuan Zhang Ying Sun Jun She Xi Zhang Petra Reinke Hans-Dieter Volk Yanmin Zhang Yi Lv Rongqian Wu Source Type: research
MICU1's calcium sensing beyond mitochondrial calcium uptake
Biochim Biophys Acta Mol Cell Res. 2024 Mar 29:119714. doi: 10.1016/j.bbamcr.2024.119714. Online ahead of print.ABSTRACTThe discovery of MICU1 as gatekeeper of mitochondrial calcium (mCa2+) entry has transformed our understanding of mCa2+ flux. Recent studies revealed an additional role of MICU1 as a Ca2+ sensor at MICOS (mitochondrial contact site and cristae organizing system). MICU1's presence at MICOS suggests its involvement in coordinating Ca2+ signaling and mitochondrial ultrastructure. Besides its role in Ca2+ regulation, MICU1 influences cellular signaling pathways including transcription, epigenetic regulation, m...
Source: Biochimica et Biophysica Acta - March 31, 2024 Category: Biochemistry Authors: Sarah D Kaye Shanikumar Goyani Dhanendra Tomar Source Type: research
MICU1's calcium sensing beyond mitochondrial calcium uptake
Biochim Biophys Acta Mol Cell Res. 2024 Mar 29:119714. doi: 10.1016/j.bbamcr.2024.119714. Online ahead of print.ABSTRACTThe discovery of MICU1 as gatekeeper of mitochondrial calcium (mCa2+) entry has transformed our understanding of mCa2+ flux. Recent studies revealed an additional role of MICU1 as a Ca2+ sensor at MICOS (mitochondrial contact site and cristae organizing system). MICU1's presence at MICOS suggests its involvement in coordinating Ca2+ signaling and mitochondrial ultrastructure. Besides its role in Ca2+ regulation, MICU1 influences cellular signaling pathways including transcription, epigenetic regulation, m...
Source: Biochimica et Biophysica Acta - March 31, 2024 Category: Biochemistry Authors: Sarah D Kaye Shanikumar Goyani Dhanendra Tomar Source Type: research
All eyes on Eya: A unique transcriptional co-activator and phosphatase in cancer
Biochim Biophys Acta Rev Cancer. 2024 Mar 28:189098. doi: 10.1016/j.bbcan.2024.189098. Online ahead of print.ABSTRACTThe Eya family of proteins (consisting of Eyas1-4 in mammals) play vital roles in embryogenesis by regulating processes such as proliferation, migration/invasion, cellular survival and pluripotency/plasticity of epithelial and mesenchymal states. Eya proteins carry out such diverse functions through a unique combination of transcriptional co-factor, Tyr phosphatase, and PP2A/B55α-mediated Ser/Thr phosphatase activities. Since their initial discovery, re-expression of Eyas has been observed in numerous tumor...
Source: Biochimica et Biophysica Acta - March 30, 2024 Category: Biochemistry Authors: Connor J Hughes Christopher Alderman Arthur R Wolin Kaiah M Fields Rui Zhao Heide L Ford Source Type: research
All eyes on Eya: A unique transcriptional co-activator and phosphatase in cancer
Biochim Biophys Acta Rev Cancer. 2024 Mar 28:189098. doi: 10.1016/j.bbcan.2024.189098. Online ahead of print.ABSTRACTThe Eya family of proteins (consisting of Eyas1-4 in mammals) play vital roles in embryogenesis by regulating processes such as proliferation, migration/invasion, cellular survival and pluripotency/plasticity of epithelial and mesenchymal states. Eya proteins carry out such diverse functions through a unique combination of transcriptional co-factor, Tyr phosphatase, and PP2A/B55α-mediated Ser/Thr phosphatase activities. Since their initial discovery, re-expression of Eyas has been observed in numerous tumor...
Source: Biochimica et Biophysica Acta - March 30, 2024 Category: Biochemistry Authors: Connor J Hughes Christopher Alderman Arthur R Wolin Kaiah M Fields Rui Zhao Heide L Ford Source Type: research
Three species multiplexing of fluorescent dyes and gold nanoclusters recovered with fluorescence lifetime correlation spectroscopy
Biochim Biophys Acta Gen Subj. 2024 Mar 27:130611. doi: 10.1016/j.bbagen.2024.130611. Online ahead of print.ABSTRACTBiosensor applications often require the simultaneous detection of multiple analytes, with a clear need to go beyond the traditional multiplexing relying on distinct fluorescent dyes across the visible spectrum. Fluorescence lifetime correlation spectroscopy (FLCS) is a powerful approach taking advantage of the fluorescence lifetime information to separate the contributions of different fluorescent species with overlapping emission spectra. However, so far FLCS detection has been demonstrated only on binary m...
Source: Biochimica et Biophysica Acta - March 29, 2024 Category: Biochemistry Authors: Malavika Kayyil Veedu Agata Hajda Joanna Olesiak-Ba ńska J érôme Wenger Source Type: research
Global control of RNA polymerase II
Biochim Biophys Acta Gene Regul Mech. 2024 Mar 27:195024. doi: 10.1016/j.bbagrm.2024.195024. Online ahead of print.ABSTRACTRNA polymerase II (Pol II) is the multi-protein complex responsible for transcribing all protein-coding messenger RNA (mRNA). Most research on gene regulation is focused on the mechanisms controlling which genes are transcribed when, or on the mechanics of transcription. How global Pol II activity is determined receives comparatively less attention. Here, we follow a Pol II molecule's life from complex assembly to nuclear import, enzymatic activity, and degradation. We focus on how Pol II spends its ti...
Source: Biochimica et Biophysica Acta - March 29, 2024 Category: Biochemistry Authors: Alexander Gillis Scott Berry Source Type: research
METTL3 orchestrates glycolysis by stabilizing the c-Myc/WDR5 complex in triple-negative breast cancer
CONCLUSION: METTL3 binds to the c-Myc/WDR5 complex and promotes glycolysis, which plays a powerful role in promoting TNBC progression. Our findings further broaden our understanding of the role and mechanism of action of METTL3, and may open up new therapeutic avenues for effective treatment of TNBC with high c-Myc expression.PMID:38547933 | DOI:10.1016/j.bbamcr.2024.119716 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - March 28, 2024 Category: Biochemistry Authors: Xiao-Ning Yuan You-Cheng Shao Xiao-Qing Guan Qin Liu Meng-Fei Chu Ze-Lin Yang Hui Li Sai Zhao Yi-Hao Tian Jing-Wei Zhang Lei Wei Source Type: research
Compound SJ-12 attenuates streptozocin-induced diabetic cardiomyopathy by stabilizing SERCA2a
Biochim Biophys Acta Mol Basis Dis. 2024 Mar 26;1870(5):167140. doi: 10.1016/j.bbadis.2024.167140. Online ahead of print.ABSTRACTHeart failure (HF) is one of the major causes of death among diabetic patients. Although studies have shown that curcumin analog C66 can remarkably relieve diabetes-associated cardiovascular and kidney complications, the role of SJ-12, SJ-12, a novel curcumin analog, in diabetic cardiomyopathy and its molecular targets are unknown. 7-week-old male C57BL/6 mice were intraperitoneally injected with single streptozotocin (STZ) (160 mg/kg) to develop diabetic cardiomyopathy (DCM). The diabetic mice w...
Source: Biochimica et Biophysica Acta - March 28, 2024 Category: Biochemistry Authors: Shuaijie Lou Weiwei Zhu Tianxiang Yu Qianhui Zhang Minxiu Wang Leiming Jin Yongqiang Xiong Jiachen Xu Qinyan Wang Gaozhi Chen Guang Liang Xiang Hu Wu Luo Source Type: research
METTL3 orchestrates glycolysis by stabilizing the c-Myc/WDR5 complex in triple-negative breast cancer
CONCLUSION: METTL3 binds to the c-Myc/WDR5 complex and promotes glycolysis, which plays a powerful role in promoting TNBC progression. Our findings further broaden our understanding of the role and mechanism of action of METTL3, and may open up new therapeutic avenues for effective treatment of TNBC with high c-Myc expression.PMID:38547933 | DOI:10.1016/j.bbamcr.2024.119716 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - March 28, 2024 Category: Biochemistry Authors: Xiao-Ning Yuan You-Cheng Shao Xiao-Qing Guan Qin Liu Meng-Fei Chu Ze-Lin Yang Hui Li Sai Zhao Yi-Hao Tian Jing-Wei Zhang Lei Wei Source Type: research
Compound SJ-12 attenuates streptozocin-induced diabetic cardiomyopathy by stabilizing SERCA2a
Biochim Biophys Acta Mol Basis Dis. 2024 Mar 26:167140. doi: 10.1016/j.bbadis.2024.167140. Online ahead of print.ABSTRACTHeart failure (HF) is one of the major causes of death among diabetic patients. Although studies have shown that curcumin analog C66 can remarkably relieve diabetes-associated cardiovascular and kidney complications, the role of SJ-12, SJ-12, a novel curcumin analog, in diabetic cardiomyopathy and its molecular targets are unknown. 7-week-old male C57BL/6 mice were intraperitoneally injected with single streptozotocin (STZ) (160 mg/kg) to develop diabetic cardiomyopathy (DCM). The diabetic mice were then...
Source: Biochimica et Biophysica Acta - March 28, 2024 Category: Biochemistry Authors: Shuaijie Lou Weiwei Zhu Tianxiang Yu Qianhui Zhang Minxiu Wang Leiming Jin Yongqiang Xiong Jiachen Xu Qinyan Wang Gaozhi Chen Guang Liang Xiang Hu Wu Luo Source Type: research
Knockout of Brca1-interacting factor Ola1 in female mice induces tumors with estrogen suppressible centrosome amplification
Biochim Biophys Acta Mol Basis Dis. 2024 Mar 25:167138. doi: 10.1016/j.bbadis.2024.167138. Online ahead of print.ABSTRACTObg-like ATPase 1 (OLA1) is a binding protein of Breast cancer gene 1 (BRCA1), germline pathogenic variants of which cause hereditary breast cancer. Cancer-associated variants of BRCA1 and OLA1 are deficient in the regulation of centrosome number. Although OLA1 might function as a tumor suppressor, the relevance of OLA1 deficiency to carcinogenesis is unclear. Here, we generated Ola1 knockout mice. Aged female Ola1+/- mice developed lymphoproliferative diseases, including malignant lymphoma. The lymphoma...
Source: Biochimica et Biophysica Acta - March 27, 2024 Category: Biochemistry Authors: Yuki Yoshino Honami Ogoh Yudai Iichi Tomohiro Sasaki Takahiro Yoshida Shiori Ichimura Masahiro Nakayama Wu Xi Hiroki Fujita Megumi Kikuchi Zhenzhou Fang Xingming Li Takaya Abe Mitsuru Futakuchi Yasuhiro Nakamura Toshio Watanabe Natsuko Chiba Source Type: research
