Global control of RNA polymerase II

Biochim Biophys Acta Gene Regul Mech. 2024 Mar 27:195024. doi: 10.1016/j.bbagrm.2024.195024. Online ahead of print.ABSTRACTRNA polymerase II (Pol II) is the multi-protein complex responsible for transcribing all protein-coding messenger RNA (mRNA). Most research on gene regulation is focused on the mechanisms controlling which genes are transcribed when, or on the mechanics of transcription. How global Pol II activity is determined receives comparatively less attention. Here, we follow a Pol II molecule's life from complex assembly to nuclear import, enzymatic activity, and degradation. We focus on how Pol II spends its time in the nucleus, and on the two-way relationship between Pol II abundance and activity in the context of homeostasis and global transcriptional changes.PMID:38552781 | DOI:10.1016/j.bbagrm.2024.195024

Source: Biochimica et Biophysica Acta - March 29, 2024 Category: Biochemistry Authors: Alexander Gillis Scott Berry Source Type: research