All eyes on Eya: A unique transcriptional co-activator and phosphatase in cancer

Biochim Biophys Acta Rev Cancer. 2024 Mar 28:189098. doi: 10.1016/j.bbcan.2024.189098. Online ahead of print.ABSTRACTThe Eya family of proteins (consisting of Eyas1-4 in mammals) play vital roles in embryogenesis by regulating processes such as proliferation, migration/invasion, cellular survival and pluripotency/plasticity of epithelial and mesenchymal states. Eya proteins carry out such diverse functions through a unique combination of transcriptional co-factor, Tyr phosphatase, and PP2A/B55α-mediated Ser/Thr phosphatase activities. Since their initial discovery, re-expression of Eyas has been observed in numerous tumor types, where they are known to promote tumor progression through a combination of their transcriptional and enzymatic activities. Eya proteins thus reinstate developmental processes during malignancy and represent a compelling class of therapeutic targets for inhibiting tumor progression.PMID:38555001 | DOI:10.1016/j.bbcan.2024.189098
Source: Biochimica et Biophysica Acta - Category: Biochemistry Authors: Source Type: research