Exploring microRNA patterns as biomarkers of FOLFOX chemotherapy-induced peripheral neuropathy in patients with colorectal cancer
This study aimed to evaluate circulating miRNA, cortisol and catecholamine as potential biomarkers that can predict FOLFOX-CIPN symptoms. High-throughput microRNA (miRNA) sequencing was performed on the RNA circulating in the plasma of eight patients with CRC who underwent FOLFOX chemotherapy. miRNA expression profiles were evaluated according to two groups: those who underwent ≤3 cycles and those who underwent ≥6 cycles of FOLFOX chemotherapy. The identified miRNAs were validated in 27 patients with CRC who underwent FOLFOX chemotherapy using quantitative reverse transcription polymerase chain reaction. Target genes w...
Source: Biochimica et Biophysica Acta - May 3, 2024 Category: Biochemistry Authors: Yeongdon Ju Dong Hoon Baek Go-Eun Choi Aelee Jang Source Type: research
Electroacupuncture pre-treatment exerts a protective effect on LPS-induced cardiomyopathy in mice through the delivery of miR-381 via exosomes
CONCLUSIONS: Our research findings have revealed a novel endogenous cardiac protection mechanism, wherein circulating exosomes derived from EA pre-treatment mitigate LPS-induced cardiac dysfunction via miR-381.PMID:38701956 | DOI:10.1016/j.bbadis.2024.167208 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - May 3, 2024 Category: Biochemistry Authors: Yong Chen Shuangli Chen Jingyu Zhang Xiyou Hu Ningcen Li Zhen Liu Lihong Huang Jianbo Yu Yuan Zhang Xiaowei Lin Zhifang Xu Yuxin Fang Zelin Chen Yi Guo Bo Chen Source Type: research
AS1411 binds to nucleolin via its parallel structure and disrupts the exos-miRNA-27a-mediated reciprocal activation loop between glioma and astrocytes
In conclusion, the parallel structure of AS1411 allows it to bind to nucleolin and disrupt the exosome-miRNA-27a-mediated reciprocal activation loop between glioma cells and astrocytes. Our results may help in the development of a novel approach to therapeutic modulation of the glioma microenvironment.PMID:38701957 | DOI:10.1016/j.bbadis.2024.167211 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - May 3, 2024 Category: Biochemistry Authors: Xiaoming Sun Wenzi Zhang Changlong Gou Xinyu Wang Xianhui Wang Xin Shao Xiao Chen Zhuo Chen Source Type: research
PLAU, transcriptionally negatively regulated by GATA6, promotes lung squamous carcinoma cell proliferation and migration
CONCLUSION: In this work, it was revealed that PLAU is a novel oncogene for LUSC and a new molecular regulatory mechanism of GATA6 in LUSC was unveiled. Targeting the GATA6/PLAU pathway might help in the development of novel therapeutic treatment strategies for LUSC.PMID:38702016 | DOI:10.1016/j.bbamcr.2024.119744 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - May 3, 2024 Category: Biochemistry Authors: Jiankun Guo Hailong Wang Changhua Huang Caihong Lai Wenli Shang Shiwen Luo Limin Chen Source Type: research
The Hansenula polymorpha mitochondrial carrier family protein Mir1 is dually localized at peroxisomes and mitochondria
Biochim Biophys Acta Mol Cell Res. 2024 May 1:119742. doi: 10.1016/j.bbamcr.2024.119742. Online ahead of print.ABSTRACTPeroxisomes are ubiquitous cell organelles involved in various metabolic pathways. In order to properly function, several cofactors, substrates and products of peroxisomal enzymes need to pass the organellar membrane. So far only a few transporter proteins have been identified. We analysed peroxisomal membrane fractions purified from the yeast Hansenula polymorpha by untargeted label-free quantitation mass spectrometry. As expected, several known peroxisome-associated proteins were enriched in the peroxiso...
Source: Biochimica et Biophysica Acta - May 3, 2024 Category: Biochemistry Authors: Marc Pilegaard Pedersen Justina C Wolters Rinse de Boer Arjen M Krikken Ida J van der Klei Source Type: research
AS1411 binds to nucleolin via its parallel structure and disrupts the exos-miRNA-27a-mediated reciprocal activation loop between glioma and astrocytes
In conclusion, the parallel structure of AS1411 allows it to bind to nucleolin and disrupt the exosome-miRNA-27a-mediated reciprocal activation loop between glioma cells and astrocytes. Our results may help in the development of a novel approach to therapeutic modulation of the glioma microenvironment.PMID:38701957 | DOI:10.1016/j.bbadis.2024.167211 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - May 3, 2024 Category: Biochemistry Authors: Xiaoming Sun Wenzi Zhang Changlong Gou Xinyu Wang Xianhui Wang Xin Shao Xiao Chen Zhuo Chen Source Type: research
The Hansenula polymorpha mitochondrial carrier family protein Mir1 is dually localized at peroxisomes and mitochondria
Biochim Biophys Acta Mol Cell Res. 2024 May 1:119742. doi: 10.1016/j.bbamcr.2024.119742. Online ahead of print.ABSTRACTPeroxisomes are ubiquitous cell organelles involved in various metabolic pathways. In order to properly function, several cofactors, substrates and products of peroxisomal enzymes need to pass the organellar membrane. So far only a few transporter proteins have been identified. We analysed peroxisomal membrane fractions purified from the yeast Hansenula polymorpha by untargeted label-free quantitation mass spectrometry. As expected, several known peroxisome-associated proteins were enriched in the peroxiso...
Source: Biochimica et Biophysica Acta - May 3, 2024 Category: Biochemistry Authors: Marc Pilegaard Pedersen Justina C Wolters Rinse de Boer Arjen M Krikken Ida J van der Klei Source Type: research
Emerging biomarkers and molecular targets for precision medicine in cervical cancer
In conclusion, the evolving landscape of biomarkers and molecular targets presents exciting opportunities for advancing precision medicine in cervical cancer. By harnessing these insights, clinicians can optimize treatment selection, enhance patient outcomes, and ultimately transform the management of this devastating disease.PMID:38701936 | DOI:10.1016/j.bbcan.2024.189106 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - May 3, 2024 Category: Biochemistry Authors: Pankaj Garg Madhu Krishna Ayalur Raghu Subbalakshmi Sravani Ramisetty Atish Mohanty Prakash Kulkarni David Horne Ravi Salgia Sharad S Singhal Source Type: research
Cancer stem-like cells in uveal melanoma: Novel insights and therapeutic implications
Biochim Biophys Acta Rev Cancer. 2024 May 1:189104. doi: 10.1016/j.bbcan.2024.189104. Online ahead of print.ABSTRACTUveal melanoma (UM) is the most common primary ocular tumor in the adult population. Even though these primary tumors are successfully treated in 90% of cases, almost 50% of patients ultimately develop metastasis, mainly in the liver, via hematological dissemination, with a median survival spanning from 6 to 12 months after diagnosis. In this context, chemotherapy regimens and molecular targeted therapies have demonstrated poor response rates and failed to improve survival. Among the multiple reasons for ther...
Source: Biochimica et Biophysica Acta - May 3, 2024 Category: Biochemistry Authors: Alessandra Loda Francesco Semeraro Silvia Parolini Roberto Ronca Sara Rezzola Source Type: research
Impact of HMGB1 on cancer development and therapeutic insights focused on CNS malignancy
Biochim Biophys Acta Rev Cancer. 2024 May 1:189105. doi: 10.1016/j.bbcan.2024.189105. Online ahead of print.ABSTRACTThe present study explores the complex roles of High Mobility Group Box 1 (HMGB1) in the context of cancer development, emphasizing glioblastoma (GBM) and other central nervous system (CNS) cancers. HMGB1, primarily known for its involvement in inflammation and angiogenesis, emerges as a multifaceted player in the tumorigenesis of GBM. The overexpression of HMGB1 correlates with glioma malignancy, influencing key pathways like RAGE/MEK/ERK and RAGE/Rac1. Additionally, HMGB1 secretion is linked to the maintena...
Source: Biochimica et Biophysica Acta - May 3, 2024 Category: Biochemistry Authors: Sucharita Patra Pritam Kumar Roy Ankita Dey Mahitosh Mandal Source Type: research
OSBPL2 compound heterozygous variants cause dyschromatosis, ichthyosis, deafness and atopic disease syndrome
CONCLUSIONS: Our study not only unveiled the association between OSBPL2 variants and the newly identified DIDA syndrome but also shed light on the underlying mechanism.PMID:38701954 | DOI:10.1016/j.bbadis.2024.167207 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - May 3, 2024 Category: Biochemistry Authors: Yumeng Wang Anqi Zhao Naihui Zhou Xiaoxiao Wang Chaolan Pan Shengru Zhou Haisheng Huang Yijun Yang Jianqiu Yang Yifan Yang Jingwen Zhang Fuying Chen Qiaoyu Cao Jingjun Zhao Si Zhang Ming Li Min Li Source Type: research
Exploring microRNA patterns as biomarkers of FOLFOX chemotherapy-induced peripheral neuropathy in patients with colorectal cancer
This study aimed to evaluate circulating miRNA, cortisol and catecholamine as potential biomarkers that can predict FOLFOX-CIPN symptoms. High-throughput microRNA (miRNA) sequencing was performed on the RNA circulating in the plasma of eight patients with CRC who underwent FOLFOX chemotherapy. miRNA expression profiles were evaluated according to two groups: those who underwent ≤3 cycles and those who underwent ≥6 cycles of FOLFOX chemotherapy. The identified miRNAs were validated in 27 patients with CRC who underwent FOLFOX chemotherapy using quantitative reverse transcription polymerase chain reaction. Target genes w...
Source: Biochimica et Biophysica Acta - May 3, 2024 Category: Biochemistry Authors: Yeongdon Ju Dong Hoon Baek Go-Eun Choi Aelee Jang Source Type: research
Electroacupuncture pre-treatment exerts a protective effect on LPS-induced cardiomyopathy in mice through the delivery of miR-381 via exosomes
CONCLUSIONS: Our research findings have revealed a novel endogenous cardiac protection mechanism, wherein circulating exosomes derived from EA pre-treatment mitigate LPS-induced cardiac dysfunction via miR-381.PMID:38701956 | DOI:10.1016/j.bbadis.2024.167208 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - May 3, 2024 Category: Biochemistry Authors: Yong Chen Shuangli Chen Jingyu Zhang Xiyou Hu Ningcen Li Zhen Liu Lihong Huang Jianbo Yu Yuan Zhang Xiaowei Lin Zhifang Xu Yuxin Fang Zelin Chen Yi Guo Bo Chen Source Type: research
PLAU, transcriptionally negatively regulated by GATA6, promotes lung squamous carcinoma cell proliferation and migration
CONCLUSION: In this work, it was revealed that PLAU is a novel oncogene for LUSC and a new molecular regulatory mechanism of GATA6 in LUSC was unveiled. Targeting the GATA6/PLAU pathway might help in the development of novel therapeutic treatment strategies for LUSC.PMID:38702016 | DOI:10.1016/j.bbamcr.2024.119744 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - May 3, 2024 Category: Biochemistry Authors: Jiankun Guo Hailong Wang Changhua Huang Caihong Lai Wenli Shang Shiwen Luo Limin Chen Source Type: research
Procollagen-lysine 2-oxoglutarate 5-dioxygenase 2 promotes collagen cross-linking and ECM stiffening to induce liver fibrosis
Biochim Biophys Acta Mol Basis Dis. 2024 May 1;1870(5):167205. doi: 10.1016/j.bbadis.2024.167205. Online ahead of print.ABSTRACTProcollagen-lysine 2-oxoglutarate 5-dioxygenase 2 (Plod2) is a key collagen lysyl hydroxylase mediating the formation of collagen fiber and stabilized collagen cross-links, and has been identified in several forms of fibrosis. However, the potential role and regulatory mechanism of Plod2 in liver fibrosis remain unclear yet. Mouse liver fibrosis models were induced by injecting carbon tetrachloride (CCl4) intraperitoneally. The morphology and alignment of collagen was observed under transmission a...
Source: Biochimica et Biophysica Acta - May 2, 2024 Category: Biochemistry Authors: Wenhui Yue Hang Zhang Yue Gao Jingru Ding Renmin Xue Chengbin Dong Fuquan Liu Lin Yang Le Yang Liying Li Source Type: research
