PLAU, transcriptionally negatively regulated by GATA6, promotes lung squamous carcinoma cell proliferation and migration

CONCLUSION: In this work, it was revealed that PLAU is a novel oncogene for LUSC and a new molecular regulatory mechanism of GATA6 in LUSC was unveiled. Targeting the GATA6/PLAU pathway might help in the development of novel therapeutic treatment strategies for LUSC.PMID:38702016 | DOI:10.1016/j.bbamcr.2024.119744
Source: Biochimica et Biophysica Acta - Category: Biochemistry Authors: Source Type: research