IU researcher makes skin cancer discovery
(Indiana University School of Medicine) An Indiana University cancer researcher has identified eight new genomic regions that increase a person's risk for skin cancer. Jiali Han, Ph.D., and colleagues discovered eight new loci--locations on a person's genome--that are susceptible to the development of squamous cell skin cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 18, 2020 Category: Cancer & Oncology Source Type: news

FDA Grants 2 Fast Track Designations for ALX148
The FDA granted 2 Fast Track designations for ALX148 for the first-line treatment of patients with head and neck squamous cell carcinoma, and for the second-line treatment of patients with HER2-positive gastric or gastroesophageal junction carcinoma. (Source: CancerNetwork)
Source: CancerNetwork - February 18, 2020 Category: Cancer & Oncology Authors: Hannah Slater Source Type: news

Staging Guidelines May be Missing Biomarkers that Affect Outcomes in OPSCC
Researchers suggested that the 2017 classifications do not currently allow for uniform stratification and proper outcome prognostication for surgically treated patients with p16-positive oropharyngeal squamous cell carcinoma. (Source: CancerNetwork)
Source: CancerNetwork - February 17, 2020 Category: Cancer & Oncology Authors: Hannah Slater Source Type: news

Gaps in cure rate appear linked to race and insurance status for common HPV-related cancer
(National Comprehensive Cancer Network) Largest population-based analysis to date on outcomes for HPV-positive oropharyngeal squamous cell carcinoma of the head and neck (SCCHN) finds significant racial and socioeconomic disparities, according to new research in JNCCN-Journal of the National Comprehensive Cancer Network. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 6, 2020 Category: Cancer & Oncology Source Type: news

UArizona receives $6.9m grant to study prevention of non-melanoma skin cancer
(University of Arizona Health Sciences) Skin cancer is the most common malignancy worldwide, and one in three new cancers diagnosed is a form of skin cancer. In response, a team of researchers at the University of Arizona Cancer Center is developing new strategies to prevent and reduce the risk of squamous cell carcinoma, the second most-common form of non-melanoma skin cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 5, 2020 Category: Cancer & Oncology Source Type: news

Clostridium perfringens enterotoxin induces claudin-4 to activate YAP in oral squamous cell
(Impact Journals LLC) Oncotarget Volume 11, Issue 4: Treatment of human oral squamous cell carcinoma cell lines HSC3 and HSC4 with Clostridium perfringens enterotoxin, induced CLDN4 nuclear translocation to enhance epithelial-mesenchymal transition, stemness, cell proliferation, and invasive ability. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 4, 2020 Category: Cancer & Oncology Source Type: news

Scientists find RNA affecting skin cancer progression
(University of Turku) Researchers at the University of Turku, Turku University Central Hospital, and Western Cancer Center (FICAN West) have discovered a new RNA molecule, PRECSIT, which regulates the growth and invasion of squamous cell carcinoma of the skin. In the future, PRECSIT could potentially serve as a new marker for the detection of rapidly advancing or spreading squamous cell carcinoma and as a target for new therapies. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 4, 2020 Category: Cancer & Oncology Source Type: news

The virome of HPV-positive tonsil squamous cell carcinoma and neck metastasis
(Impact Journals LLC) In this prospective study, a pan-pathogen microarray was used to determine the virome of early stage, p16-positive OPSCC and neck metastasis treated with transoral robotic surgery and neck dissection. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 27, 2020 Category: Cancer & Oncology Source Type: news

HPV-Positive Sinonasal Squamous Cell Carcinoma May Be Associated with Improved OS
This research indicated that routine HPV testing may be necessary for patients with squamous cell carcinoma. (Source: CancerNetwork)
Source: CancerNetwork - January 24, 2020 Category: Cancer & Oncology Authors: Hannah Slater Source Type: news

Revealed an alteration related to the loss of effectiveness of a treatment in lung cancer
(Josep Carreras Leukaemia Research Institute) Researchers from IJC reveal that non-smoking patients with lung cancer that have an alteration in RB1 and are treated with EGFR inhibitors, acquire resistance to treatment through the mechanism of histopathological transformation, either to non-small cell lung cancer (SCLC) or SLCL combined with a transformation to squamous cell lung cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 23, 2020 Category: Cancer & Oncology Source Type: news

GW Cancer Center expands clinical trial offerings for cutaneous squamous cell carcinoma
(George Washington University) The Cutaneous Oncology Program at the GW Cancer Center was selected as the first global site for a clinical trial for patients with high-risk cutaneous squamous cell carcinoma. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 22, 2020 Category: Cancer & Oncology Source Type: news

Head/neck cancer diagnosis, time to treatment after ACA Medicaid expansions
(JAMA Network) Researchers for this observational study examined the association between the expansion of Medicaid coverage in some states after the Patient Protection and Affordable Care Act (ACA) was passed and the diagnosis and treatment of patients with head and neck squamous cell carcinoma (HNSCC). The analysis included nearly 91,000 adults with newly diagnosed HNSCC who were identified from the National Cancer Database. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 16, 2020 Category: Cancer & Oncology Source Type: news

Routine HPV Testing May Be Warranted for Sinonasal Cancers
FRIDAY, Jan. 3, 2020 -- Only one in four patients with sinonasal squamous cell carcinoma (SNSCC) is tested for human papillomavirus (HPV), according to a study published online Dec. 30 in Cancer. Jamie R. Oliver, from the New York University School... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - January 3, 2020 Category: Pharmaceuticals Source Type: news

ASTRO Releases Clinical Guideline for Radiation Therapy in Treating Patients with Skin Cancer
The recommendations defined when and how radiation therapy should be used to treat patients with basal cell carcinoma and cutaneous squamous cell carcinoma. (Source: CancerNetwork)
Source: CancerNetwork - December 31, 2019 Category: Cancer & Oncology Authors: Hannah Slater Source Type: news

Five-inch HORN removed from man's back was skin cancer
WARNING: GRAPHIC CONTENT: The horn was the result of a common cancer called a squamous cell carcinoma (SCC). Doctors in Chester removed it and covered the hole with a skin graft. (Source: the Mail online | Health)
Source: the Mail online | Health - December 30, 2019 Category: Consumer Health News Source Type: news

The man with a five-inch HORN sticking out of his back: Labourer's lump turned out to be skin cancer
WARNING: GRAPHIC CONTENT: The horn was the result of a common cancer called a squamous cell carcinoma (SCC). Doctors in Chester removed it and covered the hole with a skin graft. (Source: the Mail online | Health)
Source: the Mail online | Health - December 30, 2019 Category: Consumer Health News Source Type: news

ASTRO Issues Recs for Radiation Tx of Basal, Squamous Cell Carcinoma
RT recommended as primary treatment for BCC, cSCC patients who are not surgical candidates (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - December 24, 2019 Category: Cancer & Oncology Tags: Dermatology, Oncology, Radiology, Surgery, Journal, Source Type: news

ASTRO Issues Recs for Radiation Tx of Basal, Squamous Cell Carcinoma
TUESDAY, Dec. 24, 2019 -- In an executive summary of an American Society for Radiation Oncology clinical practice guideline, published online Dec. 9 in Practical Radiation Oncology, recommendations are presented for the use of radiation therapy (RT)... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - December 24, 2019 Category: Pharmaceuticals Source Type: news

Clinical Guideline Released for Radiation Therapy in Treating Patients with Skin Cancer
Recommendations defined when and how radiation therapy should be used to treat patients with basal cell carcinoma and cutaneous squamous cell carcinoma. (Source: CancerNetwork)
Source: CancerNetwork - December 20, 2019 Category: Cancer & Oncology Authors: Hannah Slater Source Type: news

FDA Grants Fast Track Designation to Tipifarnib for the Treatment of Patients with HNSCC
The drug candidate tipifarnib (Zarnestra) is being clinically studied for the treatment of patients with  HRAS-mutant head and neck squamous cell carcinoma after progression on platinum therapy.  (Source: CancerNetwork)
Source: CancerNetwork - December 16, 2019 Category: Cancer & Oncology Authors: Hannah Slater Source Type: news

Squamous Cell Carcinoma Arising From an Epidermal Cyst Squamous Cell Carcinoma Arising From an Epidermal Cyst
In this report, a patient presented with a rare malignant transformation of an epidermal cyst. How was this case successfully treated, and what was the outcome?ePlasty, Open Access Journal of Plastic Surgery (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 10, 2019 Category: Consumer Health News Tags: Plastic Surgery & Aesthetic Medicine Journal Article Source Type: news

ASTRO issues new guideline on radiation therapy for basal, squamous cell skin cancers
(American Society for Radiation Oncology) A new clinical guideline from the American Society for Radiation Oncology (ASTRO) provides recommendations on the use of radiation therapy to treat patients diagnosed with the most common types of skin cancers. The guideline details when radiation treatments are appropriate as stand-alone therapy or following surgery for basal and cutaneous squamous cell carcinomas (BCC, cSCC), and it suggests dosing and fractionation for these treatments. ASTRO's first guideline for skin cancer published in Practical Radiation Oncology. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - December 10, 2019 Category: Cancer & Oncology Source Type: news

NOTCH1 signaling in oral squamous cell carcinoma via a TEL2/SERPINE1 axis
In this study, the research team investigated NOTCH1 mutations in keratinocyte lines derived from OSCC biopsies that had been subjected to whole exome sequencing. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - December 4, 2019 Category: Cancer & Oncology Source Type: news

Incidence of Squamous Cell Carcinoma of the Anus Increasing
Greater increase seen for distant - stage and regional - stage SCCA than for localized - stage SSCA (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - November 20, 2019 Category: Cancer & Oncology Tags: Family Medicine, Gastroenterology, Gynecology, Internal Medicine, Oncology, Journal, Source Type: news

Incidence of Squamous Cell Carcinoma of the Anus Increasing
WEDNESDAY, Nov. 20, 2019 -- There has been an increase in the incidence of squamous cell carcinoma of the anus (SCCA) in the United States, according to a study published online Nov. 19 in the Journal of the National Cancer Institute. Ashish A.... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - November 20, 2019 Category: Pharmaceuticals Source Type: news

New advances in the treatment of advanced lung cancer
The University of Barcelona (UB) and Hospital Clínic de Barcelona collaborate with Boehringer Ingelheim Inc. to improve the efficiency of nintedanib, an antiangiogenic and antifibrotic drug, for the treatment of lung cancer. This public-private collaboration enabled researchers identify molecular mechanisms underlying the lack of efficiency of this drug in squamous cell carcinoma, a sub-type of non-small cell lung cancer, and the important role of smoking in this lack of effectivity. (Source: World Pharma News)
Source: World Pharma News - November 19, 2019 Category: Pharmaceuticals Tags: Featured Research Research and Development Source Type: news

New advances in the treatment of advanced lung cancer
(University of Barcelona) The University of Barcelona (UB) and Hospital Cl í nic de Barcelona collaborate with Boehringer Ingelheim Inc. to improve the efficiency of nintedanib, an antiangiogenic and antifibrotic drug, for the treatment of lung cancer. This public-private collaboration enabled researchers identify molecular mechanisms underlying the lack of efficiency of this drug in squamous cell carcinoma, a sub-type of non-small cell lung cancer, and the important role of smoking in this lack of effectivity. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 19, 2019 Category: Cancer & Oncology Source Type: news

Putting a Price on Life: Is the Answer Outside Pharma?
 To cure the previously incurable we must take two giant steps: the first towards better understanding the science behind a cure, and the second towards ensuring accessibility for those people in need of the treatment.   Although there is still much to discover, we got the science right some time ago. The first gene replacement therapy – Gendicine (Shenzhen SiBiono GeneTech) – was approved in China in 2003 and has been successfully administered to more than 30,000 patients with head and neck squamous cell carcinoma. A single dose of this medication costs $400.  Another example of early ...
Source: EyeForPharma - November 4, 2019 Category: Pharmaceuticals Authors: Nicola Davies Source Type: news

Tipifarnib Shows Responses in HRAS-Mutant Head and Neck Cancers
A new inhibitor may help patients with a certain subset of head and neck squamous cell carcinoma. (Source: CancerNetwork)
Source: CancerNetwork - October 30, 2019 Category: Cancer & Oncology Authors: Seth Augenstein Source Type: news

Indoor Tanning May Up Risk for Squamous Cell Carcinoma
Dose - response association found between indoor tanning and SCC risk among women (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - October 7, 2019 Category: Cancer & Oncology Tags: Dermatology, Family Medicine, Gynecology, Internal Medicine, Nursing, Oncology, Journal, Source Type: news

Indoor Tanning May Up Risk for Squamous Cell Carcinoma
MONDAY, Oct. 7, 2019 -- There is a dose-response association between indoor tanning and risk for cutaneous squamous cell carcinoma in women, according to a study published online Oct. 2 in JAMA Dermatology. Simon Lergenmuller, from the University of... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - October 7, 2019 Category: Pharmaceuticals Source Type: news

Medical News Today: Indoor tanning and skin cancer risk across the years
Researchers looking at indoor tanning and cutaneous squamous cell carcinoma find that the overall number of tanning sessions links to increased risk. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 4, 2019 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news

Foods High in Vitamin A May Help Ward Off Skin Cancer
Diets high in vitamin A were linked to a lower risk for squamous cell carcinoma. (Source: NYT Health)
Source: NYT Health - October 1, 2019 Category: Consumer Health News Authors: Nicholas Bakalar Tags: Vitamins Skin Cancer Vitamin A Diet and Nutrition Fruit Vegetables Source Type: news

Hip Fracture With Resistance to Care
Mrs. B is a 100-year-old white female with a history of dementia, squamous cell carcinoma to the bilateral lower extremities, and venous insufficiency. She is no longer able to verbally express her opinions or desires, although she recognizes familiar faces and engages with others. She requires minimal assistance with transfers and ambulates with a front-wheeled walker. She is resistant and combative with care (usually hitting staff), especially during dressing, bathing, and transferring. (Source: Caring for the Ages)
Source: Caring for the Ages - October 1, 2019 Category: Health Management Authors: Barbara Resnick, Paige Hector Tags: Interdisciplinary Team Source Type: news

ASTRO: NSAIDs May Offer Benefit to Head & amp; Neck Cancer Patients
MONDAY, Sept. 23, 2019 -- Nonsteroidal anti-inflammatory drugs (NSAIDs) are correlated with better overall survival in patients with head and neck squamous cell carcinoma (HNSCC), and there is a nonsignificant benefit for aspirin use in non-small... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - September 23, 2019 Category: Pharmaceuticals Source Type: news

Can Aspirin Help Tackle Some Cancers?
MONDAY, Sept. 23, 2019 -- Low-dose aspirin may improve survival odds for patients battling head/neck and lung cancer, two new studies suggest. The first reviewed data on 460 patients with head and neck squamous cell carcinoma (HNSCC) or early stage... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - September 23, 2019 Category: General Medicine Source Type: news

Mohs Micrographic Surgery vs. Standard Excision for cSCC Mohs Micrographic Surgery vs. Standard Excision for cSCC
Does Mohs micrographic surgery of squamous cell carcinomas of the head and neck result in a lower rate of recurrence as compared to standard excision?The British Journal of Dermatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - September 10, 2019 Category: Consumer Health News Tags: Dermatology Journal Article Source Type: news

Mother, 47, diagnosed with skin cancer INSIDE her breast in 'rare phenomenon'
Michelle Miller, from Florida, was diagnosed with squamous cell carcinoma on the inside of her breast in May, and had both her breasts removed before giving birth to her daughter, Macy, in July. (Source: the Mail online | Health)
Source: the Mail online | Health - August 28, 2019 Category: Consumer Health News Source Type: news

Immune Checkpoint Inhibitors for Treating Advanced CSCC Immune Checkpoint Inhibitors for Treating Advanced CSCC
An immune-checkpoint inhibitor is the first systemic drug approved for advanced cutaneous squamous cell carcinomas--paving the way for further immunotherapies against CSCC.American Journal of Clinical Dermatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - August 28, 2019 Category: Consumer Health News Tags: Dermatology Journal Article Source Type: news

Questions Remain About the Role of Transoral Surgery for Oropharyngeal Cancer
Researchers compared the swallowing-related quality-of-life scores of patients with  oropharyngeal squamous cell carcinoma who received radiotherapy and patients who received transoral robotic surgery with neck dissection. (Source: CancerNetwork)
Source: CancerNetwork - August 19, 2019 Category: Cancer & Oncology Authors: Leah Lawrence Source Type: news

Should Surveillance Schedules Apply to HPV-Associated Oropharyngeal Squamous Cell Carcinomas?
A new study looked at what methods were used to detect recurrences of  human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma to see if surveillance guidelines recommended by the National Comprehensive Cancer Center were effective. (Source: CancerNetwork)
Source: CancerNetwork - August 16, 2019 Category: Cancer & Oncology Authors: Leah Lawrence Source Type: news

California woman shocked to find out the 'pimple' above her lip turned out to be skin cancer
Tracy French, from Arcadia, California, was diagnosed with a type of skin cancer - squamous cell carcinoma - after what she thought was a pimple above her lip turned into a red, scaly patch. (Source: the Mail online | Health)
Source: the Mail online | Health - August 15, 2019 Category: Consumer Health News Source Type: news

Celebrity favorite keto diet may stop one type of cancer in its tracks by cutting off its sugar fuel
Researchers at the University of Texas found mice on the diet, who had squamous cell carcinoma, did not experience any growth of their tumors, though the tumors didn't shrink. (Source: the Mail online | Health)
Source: the Mail online | Health - August 13, 2019 Category: Consumer Health News Source Type: news

Dietary Vitamin A Intake Tied to Reduced Risk for Squamous Cell Carcinoma
Cutaneous SCC risk reduced for highest versus lowest quintile of vitamin A, retinol, some carotenoids (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - August 1, 2019 Category: Cancer & Oncology Tags: Dermatology, Oncology, Pathology, Pharmacy, Journal, Source Type: news

Dietary Vitamin A Intake Tied to Reduced Risk for Squamous Cell Carcinoma
THURSDAY, Aug. 1, 2019 -- Increased dietary vitamin A seems to be associated with a reduced risk for incident cutaneous squamous cell carcinoma (SCC), according to a study published online July 31 in JAMA Dermatology. Jongwoo Kim, M.D., from the... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - August 1, 2019 Category: Pharmaceuticals Source Type: news

FDA approves pembrolizumab for advanced esophageal squamous cell cancer
Oncology News burst (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - August 1, 2019 Category: Drugs & Pharmacology Authors: FDA Source Type: news

FDA Approves Keytruda (pembrolizumab) for Recurrent Locally Advanced or Metastatic Squamous Cell Carcinoma of the Esophagus
KENILWORTH, N.J.--(BUSINESS WIRE) July 31, 2019 --Merck (NYSE: MRK), known as MSD outside the United States and Canada, today announced that the U.S. Food and Drug Administration (FDA) has approved Keytruda, Merck’s anti-PD-1 therapy, as... (Source: Drugs.com - New Drug Approvals)
Source: Drugs.com - New Drug Approvals - July 31, 2019 Category: Drugs & Pharmacology Source Type: news

Vitamin A Linked to Lower Odds of Common Skin Cancer
The study of around 125,000 Americans found that people with the highest intake of vitamin A lowered their risk of squamous cell skin cancer by around 15% (Source: WebMD Health)
Source: WebMD Health - July 31, 2019 Category: Consumer Health News Source Type: news

HPV16 Antibodies Can Develop Long Before Throat Cancer Diagnosis
THURSDAY, June 13, 2019 -- Seroconversion to human papillomavirus type 16 (HPV16)-E6 antibody positivity can occur decades before diagnosis of oropharyngeal squamous cell carcinoma (OPSCC), according to a study published online June 12 in the Annals... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - June 13, 2019 Category: Pharmaceuticals Source Type: news

FDA Approves First-Line Pembrolizumab for Head/Neck Squamous Cell Carcinoma
The FDA approved pembrolizumab for the first-line treatment of patients with metastatic or unresectable recurrent head and neck squamous cell carcinoma. (Source: CancerNetwork)
Source: CancerNetwork - June 12, 2019 Category: Cancer & Oncology Authors: Erin Kayata Source Type: news