Mayo Clinic Minute: 3 types of skin cancer
There's no questions that sun exposure increases your risk of skin cancer. ?Skin cancer is the most common type of cancer in the U.S., according to the Centers for Disease Control and Prevention.?Dr. Dawn Davis, a Mayo Clinic dermatologist, says there are three main types of skin cancer: basal cell carcinoma, squamous cell carcinoma and [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - April 8, 2019 Category: Databases & Libraries Source Type: news

Precursor Immunotherapy to Prevent Squamous Cell Carcinoma
Researchers evaluated whether  treatment with calcipotriol plus 5-fluorouracil aided in reducing the risk of squamous cell carcinoma. (Source: CancerNetwork)
Source: CancerNetwork - April 5, 2019 Category: Cancer & Oncology Authors: Naveed Saleh, MD, MS Source Type: news

Topical Immunotherapy Reduces Squamous Cell Carcinoma Risk Topical Immunotherapy Reduces Squamous Cell Carcinoma Risk
A common chemotherapy combined with a synthetic vitamin D analog eliminated actinic keratosis and decreased skin cancer risk for 3 years.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - April 1, 2019 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

Topical Immunotx for Actinic Keratosis May Prevent Cancer
MONDAY, March 25, 2019 -- A short course of calcipotriol plus 5-fluorouracil (5-FU) treatment for actinic keratosis (AK) is associated with induction of robust T cell immunity and reduced development of squamous cell carcinoma (SCC) within three... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - March 25, 2019 Category: Pharmaceuticals Source Type: news

Common Drug Combo Found to Cut Skin Cancer Odds
A two-ointment combo used to clear crusty skin growths known as actinic keratosis also has been found to greatly reduce the odds for squamous cell carcinomas (SCCs), the second most common form of skin cancer. (Source: WebMD Health)
Source: WebMD Health - March 22, 2019 Category: Consumer Health News Source Type: news

Topical immunotherapy keeps skin cancer risk at bay
(Washington University School of Medicine) A combination of two topical creams already shown to clear precancerous skin lesions from sun-damaged skin also lowers the risk that patients will later develop squamous cell carcinoma of the skin. The study, from Washington University School of Medicine in St. Louis, Massachusetts General Hospital, and Harvard Medical School, appears March 21 in JCI Insight. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 21, 2019 Category: International Medicine & Public Health Source Type: news

Immunotherapy of precancerous skin lesions may prevent squamous cell carcinoma
(Massachusetts General Hospital) A treatment previously shown to clear the precancerous skin lesions called actinic keratosis now appears to reduce the chance that the treated skin will develop squamous cell carcinomas, the second most common form of skin cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - March 21, 2019 Category: Cancer & Oncology Source Type: news

Survival Low in Some After Recurrence of Cutaneous Squamous-Cell Carcinoma Survival Low in Some After Recurrence of Cutaneous Squamous-Cell Carcinoma
Patients with cutaneous squamous-cell cancer of the head and neck who have disease recurrence after definitive treatment with surgery and postoperative radiotherapy have poor survival, according to a retrospective study.Reuters Health Information (Source: Medscape Radiology Headlines)
Source: Medscape Radiology Headlines - March 14, 2019 Category: Radiology Tags: Hematology-Oncology News Source Type: news

Chest CT May Be Better Than PET/CT for HNSCC Distant Metastasis Evaluation
MONDAY, March 11, 2019 -- As distant metastasis (DM) in head and neck squamous cell carcinoma (HNSCC) is a rare event, computed tomography of the chest may be more cost-effective for evaluation, according to a study recently published in Oral... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - March 11, 2019 Category: Pharmaceuticals Source Type: news

Study Compares Impact of Two Therapies on Survival in Squamous Cell Carcinoma
Survival rates in patients with cSCC receiving  high-dose chemoradiotherapy vs conventional radical surgery were compared. (Source: CancerNetwork)
Source: CancerNetwork - March 11, 2019 Category: Cancer & Oncology Authors: Naveed Saleh, MD, MS Source Type: news

Medical News Today: How aspirin may benefit some people with head and neck cancer
Regular use of aspirin or other NSAIDs increased survival in people with head and neck squamous cell carcinoma and alteration in the PIK3CA gene. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - January 25, 2019 Category: Consumer Health News Tags: Head and Neck Cancer Source Type: news

Amateur motorcyclist discovered he had mouth cancer after his wisdom tooth was removed
Andy Gale, 50, of  Bridgwater, Somerset was told he had stage-four squamous cell carcinoma in January 2014 after the wound left behind by a removed wisdom tooth failed to heal. (Source: the Mail online | Health)
Source: the Mail online | Health - January 17, 2019 Category: Consumer Health News Source Type: news

Advanced squamous cell carcinoma of the head and neck: Pembrolizumab prolongs survival
(Institute for Quality and Efficiency in Health Care) quamous cell carcinoma is one of the most common cancers of the skin and mucosa. Treatment options for the advanced stage have been very limited for patients with tumours of the head and neck, i.e. in the mouth, the pharynx or the larynx: If recurrences or metastases occur during or after platinum-based chemotherapy, the disease is generally considered incurable. The goal is then to prolong the remaining lifetime while maintaining the best possible quality of life. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 17, 2019 Category: International Medicine & Public Health Source Type: news

Unraveling the genetic causes of skin cancer
(American University) American University Associate Professor of Biology Katie DeCicco-Skinner and her colleagues are helping to identify the genetic factors that lead to squamous cell carcinoma. In a new paper, they show how the interaction between a cell signaling pathway called MET and a gene, Tpl2, contributes to skin cancer progression. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 13, 2019 Category: Cancer & Oncology Source Type: news

Persistent Opioid Use High in Head, Neck Cancer Patients
FRIDAY, Jan. 11, 2019 -- Persistent opioid use at three and six months remains high among patients undergoing treatment for head and neck squamous cell cancer, according to a study recently published in Otolaryngology-Head and Neck Surgery. Jessica... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - January 11, 2019 Category: Pharmaceuticals Source Type: news

UCLA study shows tumors are not as addicted to glucose as previously thought
Scientists at the  Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have discovered that squamous cell skin cancers do not require increased glucose to power their development and growth, contrary to a long-held belief about cancer metabolism.The findings could lead to a better understanding of the metabolic needs of many different types of cancer, and to the development of new cancer treatments.  The research, led by senior authors Heather Christofk and Bill Lowry,  was published in the journal Nature Communications.“These findings suggest that tumors are m...
Source: UCLA Newsroom: Health Sciences - January 10, 2019 Category: Universities & Medical Training Source Type: news

UCLA study overturns dogma of cancer metabolism theory
(University of California - Los Angeles Health Sciences) Scientists at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have discovered that squamous cell skin cancers do not require increased glucose to power their development and growth, contrary to a long-held belief about cancer metabolism. The findings could bring about a better understanding of many cancers' metabolic needs and lead to the development of more effective therapies for squamous cell skin cancer and other forms of epithelial cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 9, 2019 Category: Cancer & Oncology Source Type: news

Photosensitizing Antihypertensive Drug Use and Risk of cSCC Photosensitizing Antihypertensive Drug Use and Risk of cSCC
Might treatment with photosensitizing antihypertensive drugs increase the risk of developing cutaneous squamous cell carcinoma?The British Journal of Dermatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 31, 2018 Category: Consumer Health News Tags: Dermatology Journal Article Source Type: news

Pembrolizumab Shows Modest Activity in Advanced Esophageal Cancer Pembrolizumab Shows Modest Activity in Advanced Esophageal Cancer
Pembrolizumab benefits a minority of heavily pretreated patients with advanced metastatic adenocarcinoma or squamous cell carcinoma of the esophagus, according to an open-label phase 2 trial.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - December 28, 2018 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Skin Cancer | Medscape Skin Cancer | Medscape
Nonmelanoma skin cancer primarily comprises basal cell carcinoma and squamous cell carcinoma. Other, rarer types of nonmelanoma skin cancer include dermatofibrosarcoma protuberans, Merkel cell carcinoma, and Kaposi's sarcoma. (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 28, 2018 Category: Consumer Health News Tags: Resource Center Source Type: news

Bladder Cancer | Medscape Bladder Cancer | Medscape
Bladder cancer is the second most common urologic malignancy. Transitional cell carcinoma accounts for more than 90% of cases; other types include squamous cell carcinoma and adenocarcinoma. In stage 1 disease, when the tumors are superficial, bladder cancer is treatable with transurethral resection and intravesical therapy. (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 28, 2018 Category: Consumer Health News Tags: Resource Center Source Type: news

Pembrolizumab Promising for Metastatic Head, Neck SCC
Prolongs survival among patients with recurrent, metastatic head and neck squamous cell carcinoma (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - December 20, 2018 Category: Cancer & Oncology Tags: Oncology, ENT, Pharmacy, Journal, Source Type: news

Pembrolizumab Promising for Metastatic Head, Neck SCC
THURSDAY, Dec. 20, 2018 -- For patients with recurrent or metastatic head and neck squamous cell carcinoma, pembrolizumab has a favorable safety profile and is associated with prolongation of overall survival, according to a study published online... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - December 20, 2018 Category: Pharmaceuticals Source Type: news

TRIM29: A New Target in Treatment of Squamous Cell Carcinoma?
A new study inCancer Research evaluated the function of TRIM29 in regulating  keratin distribution and migration/invasion of SCC. (Source: CancerNetwork)
Source: CancerNetwork - December 19, 2018 Category: Cancer & Oncology Authors: Naveed Saleh, MD, MS Source Type: news

CNIO and Hospital 12 de Octubre extend effectiveness of immunotherapy to more lung cancer patients
(Centro Nacional de Investigaciones Oncol ó gicas (CNIO)) Combining immunotherapy with chemotherapy in patients with metastatic squamous cell carcinoma 'significantly increases' the survival of patients.Squamous cell carcinoma represents 20 percent to 30 percent of all cases of lung cancer and has a worse prognosis than other variants. It has the least amount of progress in terms of treatment.Patients who received chemotherapy and immunotherapy extended their survival by almost 16 months on average, compared to 11.3 months for those who received chemotherapy alone. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 3, 2018 Category: International Medicine & Public Health Source Type: news

How Useful Are Immune Checkpoint Markers in Squamous Cell Carcinoma?
A recent study examined the literature on whether immune checkpoint molecules improve overall survival in oral squamous cell carcinoma. (Source: CancerNetwork)
Source: CancerNetwork - November 29, 2018 Category: Cancer & Oncology Authors: Naveed Saleh, MD, MS Source Type: news

Skin cancer rates far higher than previously thought, according to new national database
(Queen Mary University of London) Data from a newly established UK skin cancer database, the largest of its kind in the world, has revealed that there are over 45,000 cutaneous squamous cell carcinomas every year in England, 350 percent more than previous estimates suggested. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 28, 2018 Category: International Medicine & Public Health Source Type: news

Is Controversy Over NCRT Plus Surgery Warranted in Esophageal Squamous Cell Carcinoma?
A new study adds to evidence examining whether neoadjuvant chemoradiotherapy plus surgery improves survival vs surgery alone in locally advanced ESCC. (Source: CancerNetwork)
Source: CancerNetwork - October 31, 2018 Category: Cancer & Oncology Authors: John Schieszer Source Type: news

Biomarker blood test confirms remission in patients with HPV+ oral cancer
(American Society for Radiation Oncology) A highly sensitive blood test that detects minute traces of cancer-specific DNA has been shown to accurately determine whether patients with HPV-related oropharyngeal squamous cell carcinoma (OPSCC) are free from cancer following radiation therapy. Findings will be presented today at the 60th Annual Meeting of the American Society for Radiation Oncology (ASTRO). (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 23, 2018 Category: Cancer & Oncology Source Type: news

HPV blood test shows promise for tracking head and neck cancer after treatment
(UNC Lineberger Comprehensive Cancer Center) Researchers will present preliminary findings at the 60th Annual Meeting of the American Society for Radiation Oncology in San Antonio on Tuesday, Oct. 23, from a study that evaluated a blood test for HPV-linked oropharyngeal squamous cell carcinoma. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 23, 2018 Category: Cancer & Oncology Source Type: news

NUS researchers elucidate roles TP63 and SOX2 in squamous cell cancer progression
(National University of Singapore) Researchers from the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore have identified a SCC-specific protein complex activated by TP63 and SOX2 which triggers a gene cascade that promotes SCC growth. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 14, 2018 Category: Cancer & Oncology Source Type: news

FDA Approves First Drug for Advanced cSCC
Cemiplimab (Libtayo), approved for advanced cutaneous squamous cell carcinoma, is intended for those not eligible for curative surgery or radiation. (Source: CancerNetwork)
Source: CancerNetwork - October 11, 2018 Category: Cancer & Oncology Authors: Naveed Saleh, MD, MS Source Type: news

Increased survival in patients with metastatic NSCLC receiving treatment in academic centers
(International Association for the Study of Lung Cancer) Patients with metastatic NSCLC receiving treatment at academic centers (ACs) have an increased 2-year survival compared to patients treated at community-based centers (CCs). An overall histology-dependent survival was also noted in patients with adenocarcinoma verses squamous cell carcinoma and varied by treatment facility. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 10, 2018 Category: Cancer & Oncology Source Type: news

FDA approves Sanofi and Regeneron's skin cancer med
The imunotherapy Libtayo can treat patients with particular kinds of cutaneous squamous cell carcinoma. (Source: PharmaManufacturing.com)
Source: PharmaManufacturing.com - October 2, 2018 Category: Pharmaceuticals Source Type: news

' Transformational' Results in Squamous Cell Lung Cancer'Transformational' Results in Squamous Cell Lung Cancer
An immuno-chemotherapy combination again moves the bar forward in a difficult-to-treat subset of squamous cell lung cancer patients.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - October 2, 2018 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

FDA Approves New Treatment for Squamous Cell Carcinoma
Libtayo is the sixth FDA - approved immune checkpoint inhibitor targeting the PD - 1 pathway (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - October 2, 2018 Category: Cancer & Oncology Tags: Dermatology, Oncology, Pharmacy, Institutional, Source Type: news

First treatment approved for common form of advanced skin cancer
The FDA has approved the first treatment for patients with metastatic cutaneous squamous cell carcinoma who are not candidates for surgery or radiation. (Source: Health News - UPI.com)
Source: Health News - UPI.com - October 1, 2018 Category: Consumer Health News Source Type: news

FDA Approves Cemiplimab, First Drug for Advanced CSCC FDA Approves Cemiplimab, First Drug for Advanced CSCC
The US Food and Drug Administration today approved cemiplimab for the treatment of patients with metastatic cutaneous squamous cell carcinoma (CSCC) or locally advanced, unresectable CSCC.FDA Approvals (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - September 29, 2018 Category: Consumer Health News Tags: Hematology-Oncology News Alert Source Type: news

FDA Approves Libtayo (cemiplimab-rwlc) for Advanced Cutaneous Squamous Cell Carcinoma
September 28, 2018 -- The U.S. Food and Drug Administration today approved Libtayo (cemiplimab-rwlc) injection for intravenous use for the treatment of patients with metastatic cutaneous squamous cell carcinoma (CSCC) or locally advanced CSCC who... (Source: Drugs.com - New Drug Approvals)
Source: Drugs.com - New Drug Approvals - September 28, 2018 Category: Drugs & Pharmacology Source Type: news

FDA approves first treatment for advanced form of the second most common skin cancer
FDA approves Libtayo (cemiplimab-rwlc) for the treatment of patients with metastatic cutaneous squamous cell carcinoma (CSCC) or locally advanced CSCC who are not candidates for curative surgery or curative radiation. This is the first FDA approval of a drug specifically for advanced CSCC. (Source: Food and Drug Administration)
Source: Food and Drug Administration - September 28, 2018 Category: American Health Source Type: news

FDA approves first treatment for advanced form of the second most common skin cancer
The U.S. Food and Drug Administration today approved Libtayo (cemiplimab-rwlc) injection for intravenous use for the treatment of patients with metastatic cutaneous squamous cell carcinoma (CSCC) or locally advanced CSCC who are not candidates for curative surgery or curative radiation. This is the first FDA approval of a drug specifically for advanced CSCC. (Source: World Pharma News)
Source: World Pharma News - September 28, 2018 Category: Pharmaceuticals Tags: Featured FDA Regulatory Affairs Source Type: news

DNA vaccine leads to immune responses in HPV-related head and neck cancer
(University of Pennsylvania School of Medicine) A therapeutic vaccine can boost antibodies and T cells, helping them infiltrate tumors and fight off human papillomavirus (HPV)-related head and neck cancer. Researchers from the Abramson Cancer Center of the University of Pennsylvania tested the immunotherapy approach in two groups of patients with advanced head and neck squamous cell carcinoma (HNSCCa) and found 86 percent showed elevated T cell activity. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 21, 2018 Category: Cancer & Oncology Source Type: news

CRISPR screen reveals new targets in more than half of all squamous cell carcinomas
(University of Colorado Anschutz Medical Campus) Team of University of Colorado Cancer Center researchers sheds light on p63 activity in squamous cell carcinoma of the lung, providing an actionable path forward to drug development against this known cause of cancer. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 18, 2018 Category: International Medicine & Public Health Source Type: news

Total of 43,371 New Cases of HPV-Associated Cancers in 2015
TUESDAY, Sept. 11, 2018 -- A total of 43,371 new cases of human papillomavirus (HPV)-associated cancers were reported in 2015, with oropharyngeal squamous cell carcinoma (SCC) being the most common HPV-associated cancer, according to research... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - September 11, 2018 Category: Pharmaceuticals Source Type: news

Study links widely-used drug azathioprine to skin cancers
(University of Dundee) A drug used to treat inflammatory bowel disease, arthritis and vasculitis as well as to prevent organ rejection in transplant patients has been identified as an important contributor to skin cancer development.The research, published in Nature Communications, identified a `strong case for an association' between the drug azathioprine and the mutational signature found in cases of cutaneous squamous cell carcinoma (cSCC), a common form of skin cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 10, 2018 Category: Cancer & Oncology Source Type: news

Study links widely used drug azathioprine to skin cancers
(University of Dundee) A drug used to treat inflammatory bowel disease, arthritis and vasculitis as well as to prevent organ rejection in transplant patients has been identified as an important contributor to skin cancer development.The research, published in Nature Communications, identified a 'strong case for an association' between the drug azathioprine and the mutational signature found in cases of cutaneous squamous cell carcinoma (cSCC), a common form of skin cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 10, 2018 Category: Cancer & Oncology Source Type: news

Gene Variant Linked to Risk of Oral Squamous Cell Carcinoma
A study shows significant association between MTHFR C677T polymorphisms and risk of oral squamous cell carcinoma. (Source: CancerNetwork)
Source: CancerNetwork - September 8, 2018 Category: Cancer & Oncology Authors: Bryant Furlow Source Type: news

Voriconazole May Boost Risk of Squamous Cell Carcinoma in Transplant Patients Voriconazole May Boost Risk of Squamous Cell Carcinoma in Transplant Patients
Recipients of lung transplants (LT) or hematopoietic cell transplants (HCT) who are taking the antifungal voriconazole may be at increased risk of squamous cell carcinoma (SCC), researchers report.Reuters Health Information (Source: Medscape Transplantation Headlines)
Source: Medscape Transplantation Headlines - September 7, 2018 Category: Transplant Surgery Tags: Hematology-Oncology News Source Type: news

Manual vs Automated Squamous Cell Carcinoma Antigen Assays Manual vs Automated Squamous Cell Carcinoma Antigen Assays
Does the automated Elecsys SCC assay provide comparable performance to a manual assay for determining squamous cell carcinoma antigen levels?Laboratory Medicine (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - September 5, 2018 Category: Consumer Health News Tags: Pathology & Lab Medicine Journal Article Source Type: news

Radn Tx Alone May Be Adequate for Stage I Anal Cancer in Elderly
THURSDAY, Aug. 30, 2018 -- For older patients with stage I squamous cell carcinoma of the anus, radiation alone is associated with outcomes that do not differ significantly from those of chemoradiation, according to research published in the July... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - August 30, 2018 Category: Pharmaceuticals Source Type: news