Mining the Unexplored Cancer Kinome for Novel Therapeutic Targets in Squamous Cell Carcinomas
NCI ’ s Center for Cancer Research (CCR) Grand Rounds
Cancer genomic sequencing has significantly impacted the understanding of the temporal and spatial genetic alterations that lead to tumorigenesis. This information enables the development of targeted therapies that result in durable and less toxic responses in patients. In regard to kinases, the biomedical community has focused research efforts on approximately 200 kinases among the 538 kinases present in the human kinome, yet siRNA screens and cancer genomic studies indicate that the vast majority of these unexplored kinases (approximately 300) are implicated in canc...
Source: Videocast - All Events - December 9, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
Oral HPV Continuum: Epidemiology of Oral HPV Infection, Persistence and HPV-related Oropharyngeal Squamous Cell Carcinoma
NIDCR Clinical Research Fellowship Grand Rounds
Oral HPV infection now causes the majority of oropharyngeal (tonsillar) cancers in the U.S. The incidence of HPV-related oropharyngeal cancer is increasing significantly, with men disproportionately affected. This talk reviews what is known about oral HPV infection, its natural history, and the epidemiology of HPV-related oropharyngeal cancers.
Gypsyamber D ’ Souza is an associate professor in epidemiology at the Johns Hopkins Bloomberg School of Public Health, with a joint appointment in the departments of International Health and Otolaryngology-Head and Neck Surgery at th...
Source: Videocast - All Events - September 14, 2016 Category: Journals (General) Tags: Upcoming Events Source Type: video
The Telomere Syndromes: A Paradigm for Molecular Medicine
The Trans-NIH GeroScience Interest Group (GSIG) cordially invites you to its winter seminar, featuring Dr. Mary Armanios. Dr. Mary Armanios is an Associate Professor in the Department of Oncology, Johns Hopkins University School of Medicine.
Dr. Armanios’ clinical and research interests focus on disorders caused by telomere dysfunction. Their goal is to define approaches to surveillance, diagnosis and treatment for patients with telomere-mediated disease. Human syndromes associated with telomere shortening were first identified in the context of dyskeratosis congenita, a premature aging syndrome that predisposes to can...
Source: Videocast - All Events - January 20, 2016 Category: Journals (General) Tags: Upcoming Events Source Type: video
