AS1411 binds to nucleolin via its parallel structure and disrupts the exos-miRNA-27a-mediated reciprocal activation loop between glioma and astrocytes

In conclusion, the parallel structure of AS1411 allows it to bind to nucleolin and disrupt the exosome-miRNA-27a-mediated reciprocal activation loop between glioma cells and astrocytes. Our results may help in the development of a novel approach to therapeutic modulation of the glioma microenvironment.PMID:38701957 | DOI:10.1016/j.bbadis.2024.167211

Source: Biochimica et Biophysica Acta - May 3, 2024 Category: Biochemistry Authors: Xiaoming Sun Wenzi Zhang Changlong Gou Xinyu Wang Xianhui Wang Xin Shao Xiao Chen Zhuo Chen Source Type: research