CHES1 modulated tumorigenesis and senescence of pancreas cancer cells through repressing AKR1B10
Biochim Biophys Acta Mol Basis Dis. 2024 May 6:167214. doi: 10.1016/j.bbadis.2024.167214. Online ahead of print.ABSTRACTPancreatic ductal adenocarcinoma (PDAC), is characteristic by a heterogeneous tumor microenvironment and gene mutations, conveys a dismal prognosis and low response to chemotherapy and immunotherapy. Here, we found that checkpoint suppressor 1 (CHES1) served as a tumor repressor in PDAC and was associated with patient prognosis. Functional experiments indicated that CHES1 suppressed the proliferation and invasion of PDAC by modulating cellular senescence. To further identify the downstream factor of CHES1...
Source: Biochimica et Biophysica Acta - May 8, 2024 Category: Biochemistry Authors: Demin Kong Yingying Wu Binghua Tong Yonghui Liang Fuyi Xu Xiaodong Chi Lei Ni Geng Tian Guilong Zhang Zhaowei Xu Source Type: research
Targeted inhibition of branched-chain amino acid metabolism drives apoptosis of glioblastoma by facilitating ubiquitin degradation of Mfn2 and oxidative stress
Biochim Biophys Acta Mol Basis Dis. 2024 May 6:167220. doi: 10.1016/j.bbadis.2024.167220. Online ahead of print.ABSTRACTGlioblastoma is one of the most challenging malignancies with high aggressiveness and invasiveness and its development and progression of glioblastoma highly depends on branched-chain amino acid (BCAA) metabolism. The study aimed to investigate effects of inhibition of BCAA metabolism with cytosolic branched-chain amino acid transaminase (BCATc) Inhibitor 2 on glioblastoma, elucidate its underlying mechanisms, and explore therapeutic potential of targeting BCAA metabolism. The expression of BCATc was upre...
Source: Biochimica et Biophysica Acta - May 8, 2024 Category: Biochemistry Authors: Zhuo Lu Gui-Feng Sun Kai-Yi He Zhen Zhang Xin-Hao Han Xin-Hui Qu Deng-Feng Wan Dongyuan Yao Fang-Fang Tou Xiao-Jian Han Tao Wang Source Type: research
Bulk and single-cell transcriptome profiling identify potential cellular targets of the long noncoding RNA Gas5 in renal fibrosis
In this study, we investigated the lncRNA Gas5 expression profile and its critical role as a potential biomarker in the progression of chronic kidney disease. Subsequently, we assessed the effect of lncRNA Gas5 deletion on renal fibrosis induced by unilateral ureteral obstruction (UUO). The results indicated that loss of lncRNA Gas5 exacerbates UUO-induced renal injury and extracellular matrix deposition. Notably, the deletion of lncRNA Gas5 had a similar effect on control mice. The fibrogenic phenotype observed in mice lacking lncRNA Gas5 correlates with peroxisome proliferator-activated receptor (PPAR) signaling pathway ...
Source: Biochimica et Biophysica Acta - May 8, 2024 Category: Biochemistry Authors: Zhang Xiang Hu Shouci Xiang Xiaojun Li Zhiyu Chen Zhejun Xia Cong He Qiang Jin Juan Chen Hongbo Source Type: research
Exogenous polyserine fibrils change membrane properties of phosphatidylcholine-liposome and red blood cells
In this study, we demonstrated that exogenous polyS fibrils but not polyS or polyQ non-fibril aggregates altered the thermal phase transition behavior of a model membrane composed of a phosphatidylcholine bilayer using differential scanning calorimetry. PolyS fibrils induced morphological changes in viable red blood cells (RBCs). However, both polyS and polyQ non-fibril aggregates had no effects on RBCs. These results highlight the possibility that extracellular fibrils generated from RAN products may alter the properties of neuronal cell membranes, which may contribute to changes in the brain pathology.PMID:38718958 | DOI...
Source: Biochimica et Biophysica Acta - May 8, 2024 Category: Biochemistry Authors: Yutaro Iizuka Akiko Katano-Toki Fumio Hayashi Jun Fujioka Hiroshi Takahashi Kazuhiro Nakamura Source Type: research
Rotavirus non-structural protein 4 usurps host cellular RIPK1-RIPK3 complex to induce MLKL-dependent necroptotic cell death
Biochim Biophys Acta Mol Cell Res. 2024 May 6:119745. doi: 10.1016/j.bbamcr.2024.119745. Online ahead of print.ABSTRACTThe dynamic interface between invading viral pathogens and programmed cell death (PCD) of the host is a finely regulated process. Host cellular demise at the end of the viral life cycle ensures the release of progeny virions to initiate new infection cycles. Rotavirus (RV), a diarrheagenic virus with double-stranded RNA genome, has been reported to trigger different types of PCD such as apoptosis and pyroptosis in a highly regulated way to successfully disseminate progeny virions. Recently our lab also sho...
Source: Biochimica et Biophysica Acta - May 8, 2024 Category: Biochemistry Authors: Pritam Chandra Upayan Patra Urbi Mukhopadhyay Arpita Mukherjee Prolay Halder Hemanta Koley Mamta Chawla-Sarkar Source Type: research
Genetic dissection of the bacterial FeS protein biogenesis machineries
Biochim Biophys Acta Mol Cell Res. 2024 May 6:119746. doi: 10.1016/j.bbamcr.2024.119746. Online ahead of print.ABSTRACTIron‑sulfur (FeS) clusters are one of the most ancient and versatile inorganic cofactors present in the three domains of life. FeS clusters are essential cofactors for the activity of a large variety of metalloproteins that play crucial physiological roles. FeS protein biogenesis is a complex process that starts with the acquisition of the elements (iron and sulfur atoms) and their assembly into an FeS cluster that is subsequently inserted into the target proteins. The FeS protein biogenesis is ensured b...
Source: Biochimica et Biophysica Acta - May 8, 2024 Category: Biochemistry Authors: Mathieu Sourice Charlotte Oriol Corinne Aubert Pierre Mandin B éatrice Py Source Type: research
Corrigendum to "The BDNF mimetic R-13 attenuates TBI pathogenesis using TrkB-related pathways and bioenergetics." [BBA: Mol. Basis. Dis. 1869 (2023) 166781]
Biochim Biophys Acta Mol Basis Dis. 2024 May 7:167217. doi: 10.1016/j.bbadis.2024.167217. Online ahead of print.NO ABSTRACTPMID:38719653 | DOI:10.1016/j.bbadis.2024.167217 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - May 8, 2024 Category: Biochemistry Authors: Pavan Thapak Gregory Smith Zhe Ying Afshin Paydar Neil Harris Fernando Gomez-Pinilla Source Type: research
Loss of cytidine deaminase expression as a potential attempt to counteract the process of carcinogenesis by reducing basal PARP-1 activity and increasing tau levels
Biochim Biophys Acta Mol Basis Dis. 2024 May 5;1870(5):167213. doi: 10.1016/j.bbadis.2024.167213. Online ahead of print.ABSTRACTCytidine deaminase (CDA) is a pyrimidine salvage pathway enzyme that catalyzes the hydrolytic deamination of free cytidine and deoxycytidine to uridine and deoxyuridine, respectively. Our team discovered that CDA deficiency is associated with several aspects of genetic instability, such as increased sister chromatid exchange and ultrafine anaphase bridge frequencies. Based on these results, we sought (1) to determine how CDA deficiency contributes to genetic instability, (2) to explore the possibl...
Source: Biochimica et Biophysica Acta - May 7, 2024 Category: Biochemistry Authors: Mounira Amor-Gu éret Source Type: research
Botulinum toxin A attenuates osteoarthritis development via inhibiting chondrocyte ferroptosis through SLC7Al1/GPX4 axis
This study was to investigate the impact and potential mechanism of BONT/A on OA in vivo and in vitro experiment. LPS increased the levels of ROS, Fe2+and Fe3+, as well as decreased GSH levels, the ratio of GSH / GSSH and mitochondrial membrane potential. It also enhanced the degeneration of extracellular matrix (ECM) and altered the ferroptosis-related protein expression in chondrocytes. BONT/A rescued LPS-induced decrease in collagen type II (Collagen II) expression and increase in matrix metalloproteinase 13 (MMP13), mitigated LPS-induced cytotoxicity in chondrocytes, abolished the accumulation of ROS and iron, upregula...
Source: Biochimica et Biophysica Acta - May 7, 2024 Category: Biochemistry Authors: Lian Zeng Yanping Liu Qingsong Wang Hongmei Wan Xiran Meng Panwen Tu Huaxian Chen Ailin Luo PengChao Hu Xudong Ding Source Type: research
Loss of cytidine deaminase expression as a potential attempt to counteract the process of carcinogenesis by reducing basal PARP-1 activity and increasing tau levels
Biochim Biophys Acta Mol Basis Dis. 2024 May 5:167213. doi: 10.1016/j.bbadis.2024.167213. Online ahead of print.ABSTRACTCytidine deaminase (CDA) is a pyrimidine salvage pathway enzyme that catalyzes the hydrolytic deamination of free cytidine and deoxycytidine to uridine and deoxyuridine, respectively. Our team discovered that CDA deficiency is associated with several aspects of genetic instability, such as increased sister chromatid exchange and ultrafine anaphase bridge frequencies. Based on these results, we sought (1) to determine how CDA deficiency contributes to genetic instability, (2) to explore the possible relati...
Source: Biochimica et Biophysica Acta - May 7, 2024 Category: Biochemistry Authors: Mounira Amor-Gu éret Source Type: research
Botulinum toxin A attenuates osteoarthritis development via inhibiting chondrocyte ferroptosis through SLC7Al1/GPX4 axis
This study was to investigate the impact and potential mechanism of BONT/A on OA in vivo and in vitro experiment. LPS increased the levels of ROS, Fe2+and Fe3+, as well as decreased GSH levels, the ratio of GSH / GSSH and mitochondrial membrane potential. It also enhanced the degeneration of extracellular matrix (ECM) and altered the ferroptosis-related protein expression in chondrocytes. BONT/A rescued LPS-induced decrease in collagen type II (Collagen II) expression and increase in matrix metalloproteinase 13 (MMP13), mitigated LPS-induced cytotoxicity in chondrocytes, abolished the accumulation of ROS and iron, upregula...
Source: Biochimica et Biophysica Acta - May 7, 2024 Category: Biochemistry Authors: Lian Zeng Yanping Liu Qingsong Wang Hongmei Wan Xiran Meng Panwen Tu Huaxian Chen Ailin Luo PengChao Hu Xudong Ding Source Type: research
Interplay between myotubularins and Ca < sup > 2+ < /sup > homeostasis
Biochim Biophys Acta Mol Cell Res. 2024 May 4:119739. doi: 10.1016/j.bbamcr.2024.119739. Online ahead of print.ABSTRACTThe myotubularin family, encompassing myotubularin 1 (MTM1) and 14 myotubularin-related proteins (MTMRs), represents a conserved group of phosphatases featuring a protein tyrosine phosphatase domain. Nine members are characterized by an active phosphatase domain C(X)5R, dephosphorylating the D3 position of PtdIns(3)P and PtdIns(3,5)P2. Mutations in myotubularin genes result in human pathologies myopathies, and several neuropathies including X-linked myotubular myopathy and Charcot-Marie-Tooth type 4B. MTM1...
Source: Biochimica et Biophysica Acta - May 6, 2024 Category: Biochemistry Authors: Ning Dai Jody Groenendyk Marek Michalak Source Type: research
Interplay between myotubularins and Ca < sup > 2+ < /sup > homeostasis
Biochim Biophys Acta Mol Cell Res. 2024 May 4:119739. doi: 10.1016/j.bbamcr.2024.119739. Online ahead of print.ABSTRACTThe myotubularin family, encompassing myotubularin 1 (MTM1) and 14 myotubularin-related proteins (MTMRs), represents a conserved group of phosphatases featuring a protein tyrosine phosphatase domain. Nine members are characterized by an active phosphatase domain C(X)5R, dephosphorylating the D3 position of PtdIns(3)P and PtdIns(3,5)P2. Mutations in myotubularin genes result in human pathologies myopathies, and several neuropathies including X-linked myotubular myopathy and Charcot-Marie-Tooth type 4B. MTM1...
Source: Biochimica et Biophysica Acta - May 6, 2024 Category: Biochemistry Authors: Ning Dai Jody Groenendyk Marek Michalak Source Type: research
E3 ubiquitin ligase RNF2 protects polymerase ι from destabilization
Biochim Biophys Acta Mol Cell Res. 2024 May 3:119743. doi: 10.1016/j.bbamcr.2024.119743. Online ahead of print.ABSTRACTHuman DNA polymerase ι (Polι) belongs to the Y-family of specialized DNA polymerases engaged in the DNA damage tolerance pathway of translesion DNA synthesis that is crucial to the maintenance of genome integrity. The extreme infidelity of Polι and the fact that both its up- and down-regulation correlate with various cancers indicate that Polι expression and access to the replication fork should be strictly controlled. Here, we identify RNF2, an E3 ubiquitin ligase, as a new interacting partner of PolÎ...
Source: Biochimica et Biophysica Acta - May 5, 2024 Category: Biochemistry Authors: Mikolaj Fedorowicz Agnieszka Halas Matylda Macias Ewa Sledziewska-Gojska Roger Woodgate Justyna McIntyre Source Type: research
E3 ubiquitin ligase RNF2 protects polymerase ι from destabilization
Biochim Biophys Acta Mol Cell Res. 2024 May 3:119743. doi: 10.1016/j.bbamcr.2024.119743. Online ahead of print.ABSTRACTHuman DNA polymerase ι (Polι) belongs to the Y-family of specialized DNA polymerases engaged in the DNA damage tolerance pathway of translesion DNA synthesis that is crucial to the maintenance of genome integrity. The extreme infidelity of Polι and the fact that both its up- and down-regulation correlate with various cancers indicate that Polι expression and access to the replication fork should be strictly controlled. Here, we identify RNF2, an E3 ubiquitin ligase, as a new interacting partner of PolÎ...
Source: Biochimica et Biophysica Acta - May 5, 2024 Category: Biochemistry Authors: Mikolaj Fedorowicz Agnieszka Halas Matylda Macias Ewa Sledziewska-Gojska Roger Woodgate Justyna McIntyre Source Type: research
