Exogenous polyserine fibrils change membrane properties of phosphatidylcholine-liposome and red blood cells

In this study, we demonstrated that exogenous polyS fibrils but not polyS or polyQ non-fibril aggregates altered the thermal phase transition behavior of a model membrane composed of a phosphatidylcholine bilayer using differential scanning calorimetry. PolyS fibrils induced morphological changes in viable red blood cells (RBCs). However, both polyS and polyQ non-fibril aggregates had no effects on RBCs. These results highlight the possibility that extracellular fibrils generated from RAN products may alter the properties of neuronal cell membranes, which may contribute to changes in the brain pathology.PMID:38718958 | DOI:10.1016/j.bbamem.2024.184331
Source: Biochimica et Biophysica Acta - Category: Biochemistry Authors: Source Type: research