Mechano-sensor Piezo1 inhibits glucagon production in pancreatic α-cells
CONCLUSION: Our study uncovers the regulatory role of the Piezo1 ion channel in α cells. Piezo1 influences glucagon production by affecting mTOR signaling pathway.PMID:38653360 | DOI:10.1016/j.bbadis.2024.167185 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - April 23, 2024 Category: Biochemistry Authors: Wenying Guo Luyang Gao Haocong Mo Handan Deng Yawen Zhao Geyang Xu Source Type: research
Decorin suppresses stemness and migration potential of malignant peripheral nerve sheath tumor through inhibiting epidermal growth factor receptor signaling
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 21:167181. doi: 10.1016/j.bbadis.2024.167181. Online ahead of print.ABSTRACTCancer stem cells (CSCs) play pivotal roles in the growth, invasion, metastasis, chemo-resistance in malignant peripheral nerve sheath tumor (MPNST). The current characterization of CSCs in MPNST is not complete. Decorin is a critical regulator of microenvironment, but its expression and function in CSCs of MPNST has not been studied. In the current study, Decorin levels and its relationship with lung and liver metastasis were determined in clinical specimens. Decorin expression in CD133-positive or CD44...
Source: Biochimica et Biophysica Acta - April 23, 2024 Category: Biochemistry Authors: Xiaotian Jia Lin Chen Cong Yu Source Type: research
Effects of stand-alone polar residue on membrane protein stability and structure
Biochim Biophys Acta Biomembr. 2024 Apr 21:184325. doi: 10.1016/j.bbamem.2024.184325. Online ahead of print.ABSTRACTHelical membrane proteins generally have a hydrophobic nature, with apolar side chains comprising the majority of the transmembrane (TM) helices. However, whenever polar side chains are present in the TM domain, they often exert a crucial role in structural interactions with other polar residues, such as TM helix associations and oligomerization. Moreover, polar residues in the TM region also often participate in protein functions, such as the Schiff base bonding between Lys residues and retinal in rhodopsin-...
Source: Biochimica et Biophysica Acta - April 23, 2024 Category: Biochemistry Authors: Yu-Chu Chang Zheng Cao Wai-Ting Chen Wei-Chun Huang Source Type: research
Molecular biology and novel therapeutics for IDH mutant gliomas: The new era of IDH inhibitors
Biochim Biophys Acta Rev Cancer. 2024 Apr 21:189102. doi: 10.1016/j.bbcan.2024.189102. Online ahead of print.ABSTRACTGliomas with Isocitrate dehydrogenase (IDH) mutation represent a discrete category of primary brain tumors with distinct and unique characteristics, behaviors, and clinical disease outcomes. IDH mutations lead to aberrant high-level production of the oncometabolite D-2-hydroxyglutarate (D-2HG), which act as a competitive inhibitor of enzymes regulating epigenetics, signaling pathways, metabolism, and various other processes. This review summarizes the significance of IDH mutations, resulting upregulation of ...
Source: Biochimica et Biophysica Acta - April 23, 2024 Category: Biochemistry Authors: Yosuke Kitagawa Ami Kobayashi Daniel P Cahill Hiroaki Wakimoto Shota Tanaka Source Type: research
Structural basis of the interaction between TFIIS and Leo1 from Arabidopsis thaliana
Biochim Biophys Acta Gene Regul Mech. 2024 Apr 20:195027. doi: 10.1016/j.bbagrm.2024.195027. Online ahead of print.NO ABSTRACTPMID:38648882 | DOI:10.1016/j.bbagrm.2024.195027 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - April 22, 2024 Category: Biochemistry Authors: Yuzhu Wang Meng Chen Haoyu Ma Zhongliang Zhu Jie Gao Shanhui Liao Jiahai Zhang Xiaoming Tu Source Type: research
Pre-eclamptic foetal programming predisposes offspring to hepatic steatosis via DNA methylation
CONCLUSION: These findings suggest a methylation-mediated epigenetic mechanism for PE-induced intergenerational lipid accumulation, impaired energy balance and obesity in offspring, and indicate the potential benefits of early interventions in offspring exposed to maternal PE to reduce their susceptibility to metabolic disorder in their later life.PMID:38648899 | DOI:10.1016/j.bbadis.2024.167189 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - April 22, 2024 Category: Biochemistry Authors: Huixi Chen Sisi Luo Xiuyu Deng Sisi Li Yiting Mao Jing Yan Yi Cheng Xia Liu Jiexue Pan Hefeng Huang Source Type: research
CPEB2 inhibits preeclampsia progression by regulating SSTR3 translation through polyadenylation
CONCLUSION: CPEB2 inhibited PE progression, which promoted trophoblast cell functions by inhibiting SSTR3 translation through polyadenylation.PMID:38648900 | DOI:10.1016/j.bbadis.2024.167191 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - April 22, 2024 Category: Biochemistry Authors: Yanhua Zhao Liran Zhang Jingjing Yang Caiwen Li Ping Li Source Type: research
TRPV3 promotes sebocyte inflammation via transcriptional modulating TLR2 in acne
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 20:167195. doi: 10.1016/j.bbadis.2024.167195. Online ahead of print.ABSTRACTAcne is a common chronic inflammatory disease of the pilosebaceous unit. Transient receptor potential vanilloid 3 (TRPV3) is an ion channel that is involved in inflammatory dermatosis development. However, the involvement of TRPV3 in acne-related inflammation remains unclear. Here, we used acne-like mice and human sebocytes to examine the role of TRPV3 in the development of acne. We found that TRPV3 expression increased in the skin lesions of Propionibacterium acnes (P. acnes)-injected acne-like mice and...
Source: Biochimica et Biophysica Acta - April 22, 2024 Category: Biochemistry Authors: Ziyu Wei Meng Gao Yihe Liu Rong Zeng Juan Liu Shuya Sun Siyuan Li Linghan Hu Ruiyu Xiang Ran Mo Zhongya Song Zhiming Chen Dan Bao Di Hua Christos C Zouboulis Yanyan Feng Ji Li Yong Yang Source Type: research
The IRE1 α-XBP1 arm of the unfolded protein response is a host factor activated in SARS-CoV-2 infection
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 20:167193. doi: 10.1016/j.bbadis.2024.167193. Online ahead of print.ABSTRACTSARS-CoV-2 infection can cause severe pneumonia, wherein exacerbated inflammation plays a major role. This is reminiscent of the process commonly termed cytokine storm, a condition dependent on a disproportionated production of cytokines. This state involves the activation of the innate immune response by viral patterns and coincides with the biosynthesis of the biomass required for viral replication, which may overwhelm the capacity of the endoplasmic reticulum and drive the unfolded protein response (U...
Source: Biochimica et Biophysica Acta - April 22, 2024 Category: Biochemistry Authors: Jose Javier Fern ández Arturo Marin Romel Rosales Rebekah Penrice-Randal Petra Mlcochova Yolanda Alvarez Fernando Villalon-Letelier Soner Yildiz Enrique P érez Raveen Rathnasinghe Anastasija Cupic Thomas Kehrer Melissa B Uccellini Sara Alonso Fernando M Source Type: research
Hippo pathway activated by circulating reactive oxygen species mediates cardiac diastolic dysfunction after acute kidney injury
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 20:167184. doi: 10.1016/j.bbadis.2024.167184. Online ahead of print.ABSTRACTAcute kidney injury (AKI) can cause distal cardiac dysfunction; however, the underlying mechanism is unknown. Oxidative stress is proved prominent in AKI-induced cardiac dysfunction, and a possible bridge role of oxidative-stress products in cardio-renal interaction has been reported. Therefore, this study aimed to investigate the critical role of circulating reactive oxygen species (ROS) in mediating cardiac dysfunction after bilateral renal ischemia-reperfusion injury (IRI). We observed the diastolic d...
Source: Biochimica et Biophysica Acta - April 22, 2024 Category: Biochemistry Authors: Xiao Han Quan Hong Fei Peng Yan Zhang Lingling Wu Xu Wang Ying Zheng Xiangmei Chen Source Type: research
Alterations in lipid metabolism accompanied by changes in protein and carotenoid content as spectroscopic markers of human T cell activation
Biochim Biophys Acta Mol Cell Biol Lipids. 2024 Apr 20:159496. doi: 10.1016/j.bbalip.2024.159496. Online ahead of print.ABSTRACTThis work aims to understand better the mechanism of cellular processes accompanying the activation of human T cells and to develop a novel, fast, label-free approach to identify molecular biomarkers for this process. Non-activated T-cell activation is a key method in cancer immunotherapy and involves the isolation of T-cells from a patient to perform a specific genetic modification. The standard methodology for confirming the activation state of T cells is based on flow cytometry, antibodies, and...
Source: Biochimica et Biophysica Acta - April 22, 2024 Category: Biochemistry Authors: Aleksandra Borek-Dorosz Anna Maria Nowakowska Paulina Laskowska Maciej Szyd łowski William Tipping Duncan Graham Katarzyna Wiktorska Przemyslaw Juszczynski Malgorzata Baranska Piotr Mrowka Katarzyna Majzner Source Type: research
Total flavonoids of Broussonetia papyrifera alleviate non-alcohol fatty liver disease via regulating Nrf2/AMPK/mTOR signaling pathways
CONCLUSION: Our experiments proved that TFBP has the therapeutic effect in NAFLD, and the activation of Nrf2 and AMPK signaling pathways should make sense.PMID:38649009 | DOI:10.1016/j.bbalip.2024.159497 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - April 22, 2024 Category: Biochemistry Authors: Qi Wang Yunfei Wei Yeling Wang Ziyang Yu Haiyan Qin Lilei Zhao Jiaqi Cheng Bingyu Shen Meiyu Jin Haihua Feng Source Type: research
Detection and quantification of Na,K-ATPase dimers in the plasma membrane of living cells by FRET-FCS
Biochim Biophys Acta Gen Subj. 2024 Apr 19:130619. doi: 10.1016/j.bbagen.2024.130619. Online ahead of print.ABSTRACTThe sodium potassium pump, Na,K-ATPase (NKA), is an integral plasma membrane protein, expressed in all eukaryotic cells. It is responsible for maintaining the transmembrane Na+ gradient and is the major determinant of the membrane potential. Self-interaction and oligomerization of NKA in cell membranes has been proposed and discussed but is still an open question. Here, we have used a combination of FRET and Fluorescence Correlation Spectroscopy, FRET-FCS, to analyze NKA in the plasma membrane of living cells...
Source: Biochimica et Biophysica Acta - April 21, 2024 Category: Biochemistry Authors: Linnea Nordahl Evgeny E Akkuratov Johannes Heimg ärtner Katja Schach Birthe Meineke Simon Els ässer Stefan Wennmalm Hjalmar Brismar Source Type: research
New insights into the regulation of bile acids synthesis during the early stages of liver regeneration: A human and experimental study
CONCLUSIONS: In human liver regeneration FGF19 upregulation may constitute a protective response from BAs excess during liver regeneration. Our findings suggest the existence of post-translational mechanisms regulating CYP7A1 activity, and therefore BAs synthesis, independent from CYP7A1/Cyp7a1 gene transcription.PMID:38642480 | DOI:10.1016/j.bbadis.2024.167166 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - April 20, 2024 Category: Biochemistry Authors: Iker Uriarte Eva Santamaria Amaya L ópez-Pascual Mar ía J Monte Josepmaria Argem í M Ujue Latasa Elena Ad án-Villaescusa Ainara Irigaray Jose M Herranz Mar ía Arechederra Jorge Basualdo Felipe Lucena Fernando J Corrales Fernando Rotellar Fernando Par Source Type: research
The nucleolus: Coordinating stress response and genomic stability
Biochim Biophys Acta Gene Regul Mech. 2024 Apr 18:195029. doi: 10.1016/j.bbagrm.2024.195029. Online ahead of print.ABSTRACTThe perception that the nucleoli are merely the organelles where ribosome biogenesis occurs is challenged. Only around 30 % of nucleolar proteins are solely involved in producing ribosomes. Instead, the nucleolus plays a critical role in controlling protein trafficking during stress and, according to its dynamic nature, undergoes continuous protein exchange with nucleoplasm under various cellular stressors. Hence, the concept of nucleolar stress has evolved as cellular insults that disrupt the structur...
Source: Biochimica et Biophysica Acta - April 20, 2024 Category: Biochemistry Authors: Katiuska Gonz ález-Arzola Source Type: research
