New insights into the regulation of bile acids synthesis during the early stages of liver regeneration: A human and experimental study

CONCLUSIONS: In human liver regeneration FGF19 upregulation may constitute a protective response from BAs excess during liver regeneration. Our findings suggest the existence of post-translational mechanisms regulating CYP7A1 activity, and therefore BAs synthesis, independent from CYP7A1/Cyp7a1 gene transcription.PMID:38642480 | DOI:10.1016/j.bbadis.2024.167166

Source: Biochimica et Biophysica Acta - April 20, 2024 Category: Biochemistry Authors: Iker Uriarte Eva Santamaria Amaya L ópez-Pascual Mar ía J Monte Josepmaria Argem í M Ujue Latasa Elena Ad án-Villaescusa Ainara Irigaray Jose M Herranz Mar ía Arechederra Jorge Basualdo Felipe Lucena Fernando J Corrales Fernando Rotellar Fernando Par Source Type: research