Scientists Report Creating the First Embryo With Human and Non-Human Primate Cells
In a ground-breaking experiment, researchers have successfully created the first human-monkey chimera. The work, published in the journal Cell, describes the the first embryo containing both human and monkey cells that was cultured for 20 days. Led by Juan Carlos Izpisua Belmonte, the study represents the culmination of decades of work in understanding early embryo development in non-human species, which Belmonte hopes will now apply to humans. But it is bound to raise serious ethical questions about the implications of combining human cells with those from a different species (even if it is a closely related one), and the...
Source: TIME: Health - April 15, 2021 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized Source Type: news

Closer to human -- Mouse model more accurately reproduces fatty liver disease
(Baylor College of Medicine) Researchers have developed a novel mouse model that reproduces many key features of human non-alcoholic fatty liver disease (NAFLD), a little-understood condition that significantly increases the risk of inflammation, fibrosis and liver cancer and ultimately requires liver transplant. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 13, 2021 Category: Cancer & Oncology Source Type: news

Deep Learning model developed at UHN to maximize lifespan after liver transplant  
(University Health Network) Researchers from University Health Network have developed and validated an innovative deep learning model to predict a patient's long-term outcome after receiving a liver transplant. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 12, 2021 Category: International Medicine & Public Health Source Type: news

Liver Transplant Emerges for Hepatic Mets in Colorectal Cancer Liver Transplant Emerges for Hepatic Mets in Colorectal Cancer
A new indication for a scarce resource?Medscape Medical News (Source: Medscape General Surgery Headlines)
Source: Medscape General Surgery Headlines - April 5, 2021 Category: Surgery Tags: Hematology-Oncology News Source Type: news

NIH scientists develop breath test for methylmalonic acidemia
Test for rare genomic condition measures disease severity and success of liver transplantation for patients. (Source: National Institutes of Health (NIH) News Releases)
Source: National Institutes of Health (NIH) News Releases - April 5, 2021 Category: American Health Source Type: news

NIH scientists develop breath test for methylmalonic acidemia
(NIH/National Human Genome Research Institute) Researchers at the National Institutes of Health have developed a breath test that measures how well patients with methylmalonic acidemia (MMA) respond to receiving liver or combined liver and kidney transplantation. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - April 5, 2021 Category: Biology Source Type: news

Sharing Mayo Clinic: Daughter quits smoking to donate liver to her mom
When she learned that a liver transplant could save her mom's life, April Wilson didn't hesitate to stop smoking and say yes to being a living donor. April Wilson smoked for 25 years and tried many times to quit, but nothing seemed to work. "I tried everything," April says. "I used every replacement therapy, Chantix, [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - April 4, 2021 Category: Databases & Libraries Source Type: news

Reverse-order heart-liver transplant helps prevent rejection for certain patients
(Mayo Clinic) All too often, patients with high levels of antibodies face major challenges getting a transplant. These highly sensitized patients have a much higher risk of death while waiting for suitable organs they are less likely to reject. But there is new hope for highly sensitized patients in need of a combined heart and liver transplant, thanks to an innovative surgical approach at Mayo Clinic. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 1, 2021 Category: International Medicine & Public Health Source Type: news

Reverse-order heart-liver transplant helps prevent rejection for highly sensitized patients
ROCHESTER, Minn. -- All too often, patients with high levels of antibodies face major challenges getting a transplant. These highly sensitized patients have a much higher risk of death while waiting for suitable organs they are less likely to reject. But there is new hope for highly sensitized patients in need of a combined heart [...] (Source: Mayo Clinic Minnesota News)
Source: Mayo Clinic Minnesota News - April 1, 2021 Category: Hospital Management Source Type: news

Mayo Clinic Q & amp;A podcast: Liver failure and transplant in children
A liver transplant is a surgical procedure that removes a liver that no longer functions properly and replaces it with a healthy liver from a deceased donor or a portion of a healthy liver from a living donor. The process for liver transplant in children is similar to the process for adults. But because children with liver [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - March 26, 2021 Category: Databases & Libraries Source Type: news

Patient With Post-COVID-19 Cholangiopathy Undergoes Successful Liver Transplant Patient With Post-COVID-19 Cholangiopathy Undergoes Successful Liver Transplant
A 47-year-old man who recovered from acute respiratory distress syndrome related to COVID-19 and then went on to develop end-stage liver disease is doing well after liver transplantation, according to a new report.Reuters Health Information (Source: Medscape Transplantation Headlines)
Source: Medscape Transplantation Headlines - March 25, 2021 Category: Transplant Surgery Tags: Gastroenterology News Source Type: news

Organ Allocation Rule Change Has Liver Recovery Teams Traveling Twice as Far Organ Allocation Rule Change Has Liver Recovery Teams Traveling Twice as Far
A change in how organs are allocated for transplant has resulted in recovery teams traveling twice as far to collect livers, a US study suggests.Reuters Health Information (Source: Medscape Transplantation Headlines)
Source: Medscape Transplantation Headlines - March 20, 2021 Category: Transplant Surgery Tags: Transplantation News Source Type: news

Minorities Underrepresented on Liver Transplant Waiting Lists Minorities Underrepresented on Liver Transplant Waiting Lists
While racial disparities'greatly diminished'after placement on a waiting list, prewait-listing disparities may be more challenging to overcome, reported lead author Curtis Warren.Medscape Medical News (Source: Medscape Gastroenterology Headlines)
Source: Medscape Gastroenterology Headlines - March 9, 2021 Category: Gastroenterology Tags: General Surgery News Source Type: news

Over 100 liver transplantations done in 10 years: ILBS
Several pediatric liver transplants that took place at the ILBS were because of the help of the "government or crowd funding", according to a statement by the institute. (Source: The Economic Times)
Source: The Economic Times - March 9, 2021 Category: Consumer Health News Source Type: news

Sharing Mayo Clinic: Transplant patient says 'I'm in the safest place I can be'
George Caceres' smile is contagious. Just ask his Mayo Clinic care team, who came to know him well during his 165-day stay after a liver transplant. "He was so pleasant to visit," says Lyda Velez, his case manager. "Even on days when he didn't feel well and didn't take off his [sleep] mask, he would [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - February 28, 2021 Category: Databases & Libraries Source Type: news

Hypothermic Machine Perfusion Prevents Complications in Donated-After-Cardiac-Death Liver Allografts Hypothermic Machine Perfusion Prevents Complications in Donated-After-Cardiac-Death Liver Allografts
When preparing livers for transplant, hypothermic oxygenated machine perfusion slashes the odds of nonanastomotic biliary stricture by two thirds, according to a European study.Reuters Health Information (Source: Medscape Transplantation Headlines)
Source: Medscape Transplantation Headlines - February 26, 2021 Category: Transplant Surgery Tags: Transplantation News Source Type: news

Cholangiocyte organoids can repair bile ducts after transplantation in the human liver
Organoid technology holds great promise for regenerative medicine but has not yet been applied to humans. We address this challenge using cholangiocyte organoids in the context of cholangiopathies, which represent a key reason for liver transplantation. Using single-cell RNA sequencing, we show that primary human cholangiocytes display transcriptional diversity that is lost in organoid culture. However, cholangiocyte organoids remain plastic and resume their in vivo signatures when transplanted back in the biliary tree. We then utilize a model of cell engraftment in human livers undergoing ex vivo normothermic perfusion to...
Source: ScienceNOW - February 18, 2021 Category: Science Authors: Sampaziotis, F., Muraro, D., Tysoe, O. C., Sawiak, S., Beach, T. E., Godfrey, E. M., Upponi, S. S., Brevini, T., Wesley, B. T., Garcia-Bernardo, J., Mahbubani, K., Canu, G., Gieseck, R., Berntsen, N. L., Mulcahy, V. L., Crick, K., Fear, C., Robinson, S., Tags: Cell Biology, Medicine, Diseases reports Source Type: news

Should Someone With Asthma Get a COVID-19 Vaccine Before Someone With Cancer? The Next Big Challenge in the Vaccine Rollout
In an ideal world, there would be enough vaccines to inoculate everyone who wanted to get immunized against COVID-19. People would get their shots on a first come, first serve basis, we’d achieve herd immunity in a matter of months and COVID-19 would become a soon-distant memory. But with some 240 million people over age 16 who need a COVID-19 vaccine (and two doses at that), and just over 42 million administered by early February, supply is far below demand, and will likely remain that way for months to come, despite vaccine makers pushing production lines as hard as they can. As the U.S. works through the vaccine ...
Source: TIME: Health - February 10, 2021 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized COVID-19 Source Type: news

New clinic to open at one of Greater Dayton's largest hospital campuses
A new clinic is slated to open in February at one of Greater Dayton's largest hospital campuses. UC Health on Monday announced plans to open a liver transplant evaluation clinic Feb. 19 at Physicians Office North — a freestanding facility at its West Chester Hospital campus in Butler County. The clinic at 7690 Discovery Drive aims to provide easier access for patients living in Dayton, Mi ddletown and Troy, the health system said. "Opening this clinic will enable more liver transplant patients… (Source: bizjournals.com Health Care News Headlines)
Source: bizjournals.com Health Care News Headlines - January 27, 2021 Category: Health Management Authors: Jacob Fisher Source Type: news

Non-Hispanic Blacks Underrepresented on Transplant Wait List
THURSDAY, Jan. 21, 2021 -- Non-Hispanic Black patients are disproportionately left off liver transplant wait lists, according to a study published online Jan. 11 in the Journal of the American College of Surgeons. Curtis Warren, M.P.H., from the... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - January 21, 2021 Category: Pharmaceuticals Source Type: news

Patients Fend for Themselves to Access COVID Antibody Treatments Patients Fend for Themselves to Access COVID Antibody Treatments
Herritz found himself very much on his own. His primary care doctor wasn't sure he qualified for treatment. His transplant team in Wisconsin, where he'd had the liver surgery, wasn't calling back.Kaiser Health News (Source: Medscape Infectious Diseases Headlines)
Source: Medscape Infectious Diseases Headlines - January 20, 2021 Category: Infectious Diseases Tags: Infectious Diseases News Source Type: news

DARZALEX FASPRO ® (daratumumab and hyaluronidase-fihj) Becomes the First FDA-Approved Treatment for Patients with Newly Diagnosed Light Chain (AL) Amyloidosis
January 15, 2021 (HORSHAM, Pa.) – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today the U.S. Food and Drug Administration (FDA) approval of DARZALEX FASPRO® (daratumumab and hyaluronidase-fihj), a subcutaneous formulation of daratumumab, in combination with bortezomib, cyclophosphamide and dexamethasone (D-VCd) for the treatment of adult patients with newly diagnosed light chain (AL) amyloidosis.[1] DARZALEX FASPRO® is the first and only FDA-approved treatment for patients with this blood cell disorder that is associated with the production of an abnormal protein, which leads to th...
Source: Johnson and Johnson - January 16, 2021 Category: Pharmaceuticals Tags: Our Company Source Type: news

Black Patients Disproportionately Left Off Liver Transplant Waitlists Black Patients Disproportionately Left Off Liver Transplant Waitlists
Liver-transplant waitlists at many US centers under-represent Black patients compared with what would be expected based on their service area, new research suggests.Reuters Health Information (Source: Medscape General Surgery Headlines)
Source: Medscape General Surgery Headlines - January 15, 2021 Category: Surgery Tags: Transplantation News Source Type: news

In lab study, nanoparticle shows promising results for treating severe allergies
For about 1 in 13 children in the U.S., usually harmless foodstuffs such as milk, eggs and peanuts can send the body ’s natural defenses into overdrive.Symptoms of food allergies can vary widely, but at worst, a systemwide allergic response can lead to anaphylaxis, a life-threatening condition characterized by a sudden drop in blood pressure and difficulty breathing.Although there are now some preventive measures for food-induced anaphylaxis, there are not yet any long-lasting solutions — treatments capable of locking the immune system into a state of tolerance, so that it doesn’t respond to allergens.Now...
Source: UCLA Newsroom: Health Sciences - January 14, 2021 Category: Universities & Medical Training Source Type: news

Scoring system to redefine how U.S. patients prioritized for liver transplant
(University of Miami Miller School of Medicine) Researchers with Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine are collaborating with faculty at the University of Pennsylvania to develop a risk score that more comprehensively prioritizes liver cancer patients for transplantation. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 13, 2021 Category: Cancer & Oncology Source Type: news

AI Metrics gets FDA nod for image analysis platform
Artificial intelligence (AI) software developer AI Metrics has garnered U.S....Read more on AuntMinnie.comRelated Reading: AI Metrics wins FDA nod for liver biopsy software AI Metrics adds to coffers AI can enhance evaluation of cancer response over time SIIM 2020: How to create robust radiology AI algorithms AI boosts assessment of cancer treatment response (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - January 12, 2021 Category: Radiology Source Type: news

Frailty Likely Contributes to Gender Gap in Liver Transplant Wait-List Mortality Frailty Likely Contributes to Gender Gap in Liver Transplant Wait-List Mortality
Among liver transplant candidates without cancer, frailty is associated with the gender gap in wait-list mortality, researchers suggest.Reuters Health Information (Source: Medscape General Surgery Headlines)
Source: Medscape General Surgery Headlines - January 7, 2021 Category: Surgery Tags: Transplantation News Source Type: news

On Waitlist for Liver Transplants, Women Die More Often Than Men
TUESDAY, Jan. 5, 2021 -- Frailty may explain why women awaiting a liver transplant are more likely than men to become too sick for a transplant or die before transplantation, a new study suggests. Exercise and a healthier diet may help narrow that... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - January 5, 2021 Category: General Medicine Source Type: news

On Waitlist for Liver Transplants, Women Die More Often Than Men
Title: On Waitlist for Liver Transplants, Women Die More Often Than MenCategory: Health NewsCreated: 1/5/2021 12:00:00 AMLast Editorial Review: 1/5/2021 12:00:00 AM (Source: MedicineNet Digestion General)
Source: MedicineNet Digestion General - January 5, 2021 Category: Nutrition Source Type: news

In Cirrhosis, Women Have Worse Frailty Scores Than Men
MONDAY, Jan. 4, 2021 -- Among patients with cirrhosis, women have worse frailty scores than men, which accounts for part of the gender gap in mortality while awaiting liver transplantation, according to a study published online Dec. 30 in JAMA... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - January 4, 2021 Category: Pharmaceuticals Source Type: news

Frailty is a factor in higher mortality for women awaiting liver transplants
(University of California - San Francisco) Women awaiting liver transplants in the United States are known to be about one-third more likely than men to become too ill to undergo surgery or die before receiving a liver. Now a study headed by UC San Francisco and Columbia University highlights the role that frailty plays in this gender gap. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 30, 2020 Category: International Medicine & Public Health Source Type: news

Patient with a heart/liver transplant says thanks 'with all my old heart and new one'
It's not like Ernie Hernandez wasn't used to the hot Arizona sun.  He was born and raised in Phoenix, Arizona, and worked as a skilled contractor in the masonry trade for 25 years. But the brutally hot sun one afternoon in 2018 proved to be too much. Ernie passed out. "After I passed out that [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - December 13, 2020 Category: Databases & Libraries Source Type: news

UAB startup company receives FDA clearance for liver imaging software
(University of Alabama at Birmingham) AI Metrics, LLC, a medical imaging startup focused on leveraging artificial intelligence to improve patient care, has received United States Food and Drug Administration 510(k) clearance and CE mark clearance for the company's Liver Surface Nodularity software. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 4, 2020 Category: International Medicine & Public Health Source Type: news

One man ’s liver transplant story: How a routine visit saved this patient’s life
When Eric Browne ’s routine physical revealed elevated enzymes in his liver, he was referred to Atrium Health Liver Care Clinic in Greensboro, North Carolina, a satellite clinic of Atrium Health Carolinas Medical Center’s liver disease and transplant program. There, he was able to get the specialized liver care he needed. Learn more about liver transplant care at Atrium Health. (Source: bizjournals.com Health Care News Headlines)
Source: bizjournals.com Health Care News Headlines - December 1, 2020 Category: Health Management Authors: Atrium Health Source Type: news

One man ’s liver transplant story: How a routine visit saved this patient’s life
When Eric Browne ’s routine physical revealed elevated enzymes in his liver, he was referred to Atrium Health Liver Care Clinic in Greensboro, North Carolina, a satellite clinic of Atrium Health Carolinas Medical Center’s liver disease and transplant program. There, he was able to get the specialized liver care he needed. Learn more about liver transplant care at Atrium Health. (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - December 1, 2020 Category: Biotechnology Authors: Atrium Health Source Type: news

Mayo Clinic Q & amp;A podcast: Mayo Clinic expands living liver donation program
More than 12,000 people in the U.S. are waiting for a liver transplant, and 1 in 5 of those on the national waiting list will die or become too sick before an organ becomes available. Due to the shortage of available deceased donor organs, Mayo Clinic in Rochester, Minnesota, is expanding its living liver donation [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - November 30, 2020 Category: Databases & Libraries Source Type: news

Huge gap in demand, supply of organs for transplant in country: AIIMS chief
AIIMS Director Dr Randeep Guleria said the AIIMS was working to "very soon" start a lung transplant programme even as it has facilities available for transplantation of heart, kidney, liver, pancreas, cornea, heart valve and bones. (Source: The Economic Times)
Source: The Economic Times - November 27, 2020 Category: Consumer Health News Source Type: news

AI Metrics wins FDA nod for liver biopsy software
Artificial intelligence (AI) software developer AI Metrics has garnered U.S....Read more on AuntMinnie.comRelated Reading: AI Metrics adds to coffers AI Metrics joins forces with Imaging Biometrics (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - November 17, 2020 Category: Radiology Source Type: news

How to Be a Living Liver Donor
TUESDAY, Nov. 17, 2020 -- About one in five Americans waiting for a liver transplant dies before getting the organ. Their odds might be better if more people knew they could donate a portion of their liver in a process called living liver... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - November 17, 2020 Category: General Medicine Source Type: news

AI can opportunistically screen for metabolic syndrome
Artificial intelligence (AI) algorithms can enable screening for metabolic...Read more on AuntMinnie.comRelated Reading: AI plus CT improves liver steatosis assessment Cardiac CT shows promise for osteoporosis screening Can radiomics improve CT lung cancer screening? Muscle metrics on chest CT can predict mortality risk AI unlocks screening potential of body CT exams (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - November 17, 2020 Category: Radiology Source Type: news

New XARELTO ® (rivaroxaban) Peripheral Artery Disease (PAD) Data from EXPLORER Clinical Research Program to be Unveiled at American Heart Association (AHA) Scientific Sessions 2020
RARITAN, N.J., November 9, 2020 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced that 10 data presentations will be shared at the virtual American Heart Association (AHA) Scientific Sessions 2020 from November 13-17. Most notably, four new sub-analyses of XARELTO® (rivaroxaban) from the landmark VOYAGER PAD trial, part of the EXPLORER global cardiovascular research program, will be presented, including two live, featured science oral presentations. “We're pleased VOYAGER PAD was selected to be front and center once again at a major medical congress, as there's an urgent need f...
Source: Johnson and Johnson - November 9, 2020 Category: Pharmaceuticals Tags: Innovation Source Type: news

When a routine doctor ’s visit leads to a liver transplant
A Yale Medicine patient shares her medical journey that began with an unexpected diagnosis of nonalcoholic steatohepatitis (NASH). (Source: Yale Science and Health News)
Source: Yale Science and Health News - November 9, 2020 Category: Universities & Medical Training Source Type: news

Janssen Submits Application to U.S. FDA for New Indication to Expand Use of XARELTO ® (rivaroxaban) in Patients with Peripheral Artery Disease
RARITAN, NJ, October 26, 2020 – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today it has submitted a supplemental New Drug Application (sNDA) to the U.S. Food and Drug Administration (FDA) for a new indication to expand the use of XARELTO® (rivaroxaban) in patients with peripheral artery disease (PAD). If approved, this new indication for the XARELTO® vascular dose (2.5 mg twice daily plus aspirin 75-100 mg once daily) would include reducing the risk of major thrombotic vascular events such as heart attack, stroke and amputation in patients after recent lower-extremity revasculariz...
Source: Johnson and Johnson - October 26, 2020 Category: Pharmaceuticals Tags: Innovation Source Type: news

James Redford, Documentarian and Environmentalist, Dies at 58
After two liver transplants, he founded an institute to increase awareness. He and his father, Robert Redford, also championed environmental films. (Source: NYT Health)
Source: NYT Health - October 22, 2020 Category: Consumer Health News Authors: Neil Genzlinger Tags: Redford, James Deaths (Obituaries) Redford, Robert Movies Documentary Films and Programs Transplants Organ Donation Environment Source Type: news

AI extracts more data from single-energy CT
An artificial intelligence (AI) algorithm was able to extract more data from...Read more on AuntMinnie.comRelated Reading: AI plus CT improves liver steatosis assessment Vuno AI system for lung CT gets approved in South Korea AI unlocks screening potential of body CT exams ISCT: Will AI for CT be radiology's killer app? SIIM: AI exploits CT sinogram data to find lung nodules (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - October 22, 2020 Category: Radiology Source Type: news

3 Win Nobel Medicine Prize for Discovering Hepatitis C Virus
(STOCKHOLM) — Americans Harvey J. Alter and Charles M. Rice and British-born scientist Michael Houghton won the Nobel Prize for medicine on Monday for their discovery of the hepatitis C virus, a major source of liver disease that affects millions worldwide. Announcing the prize in Stockholm, the Nobel Committee noted that the trio’s work identified a major source of blood-borne hepatitis that couldn’t be explained by the previously discovered hepatitis A and B viruses. Their work, dating back to the 1970s and 1980s, has helped saved millions of lives, the committee said. “Thanks to their discovery, ...
Source: TIME: Science - October 5, 2020 Category: Science Authors: DAVID KEYTON and FRANK JORDANS / AP Tags: Uncategorized News News Desk wire Source Type: news

Nobel Prize for Medicine goes to Hepatitis C discovery
The virus is a major cause of liver cancer and can lead to people needing a liver transplant. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - October 5, 2020 Category: Consumer Health News Source Type: news

New artificial intelligence models show potential for predicting outcomes
(American College of Surgeons) New applications of artificial intelligence (AI) in health care settings have shown early success in improving survival and outcomes in traffic accident victims transported by ambulance and in predicting survival after liver transplantation. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 3, 2020 Category: International Medicine & Public Health Source Type: news