Crohn's disease may be caused by immune signaling failure
(Scripps Research Institute) Scientists find that T cells in the small intestine prevent bile acid-driven stress and inflammation. The work highlights a completely new direction in Crohn's disease research, and potentially, its treatment. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 7, 2021 Category: International Medicine & Public Health Source Type: news

Bile and Potatoes, 1921
One hundred years after its invention, BCG has stood the test of time as a vaccine against tuberculosis. (Source: The Scientist)
Source: The Scientist - April 1, 2021 Category: Science Tags: Foundations Magazine Issue Source Type: news

Europe Approves Pemigatinib for Bile Duct Cancer Europe Approves Pemigatinib for Bile Duct Cancer
The oral targeted therapy is for the treatment of locally advanced or metastatic cholangiocarcinoma.International Approvals (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - March 31, 2021 Category: Cancer & Oncology Tags: Hematology-Oncology News Alert Source Type: news

Mirum Pharmaceuticals Announces FDA Acceptance of New Drug Application and Priority Review for Maralixibat in Alagille Syndrome
FOSTER CITY, Calif.--(BUSINESS WIRE)--Mar. 29, 2021-- Mirum Pharmaceuticals, Inc. (Nasdaq: MIRM) announced today that its New Drug Application (NDA) for maralixibat, an oral apical sodium dependent bile acid transporter (ASBT) inhibitor... (Source: Drugs.com - New Drug Applications)
Source: Drugs.com - New Drug Applications - March 29, 2021 Category: Drugs & Pharmacology Source Type: news

Study estimates rising global burden of gallbladder and biliary tract cancer
(Wiley) Although cancers that occur in the gallbladder or bile ducts are rare, their rates are increasing. A recent study provides details on the burden of gallbladder and biliary tract cancer (GBTC) across 195 countries and territories from 1990 to 2017. The findings are published early online inCANCER, a peer-reviewed journal of the American Cancer Society. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 22, 2021 Category: International Medicine & Public Health Source Type: news

Mayo Clinic Q & amp;A podcast: Hidden gallbladder and bile duct cancers
The gallbladder is a small, pear-shaped organ that sits just beneath the liver, on the right side of the abdomen. Slender tubes that carry bile fluid also are also located in that area. Because of the relatively hidden nature of the gallbladder and bile ducts, cancers can grow without being detected. Late detection can mean [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - February 22, 2021 Category: Databases & Libraries Source Type: news

Lab-grown ‘mini-bile ducts’ by scientists at Cambridge university used to repair human livers in regenerative medicine first
Scientists have used a technique to grow bile duct organoids – often referred to as ‘mini-organs’ – in the lab and shown that these can... (Source: Reuters: Health)
Source: Reuters: Health - February 20, 2021 Category: Consumer Health News Source Type: news

Organoids Repair Bile Ducts
Researchers determined that when introduced into damaged mouse or donated human livers, these lab-grown tissues could integrate into bile ducts and function normally. (Source: The Scientist)
Source: The Scientist - February 18, 2021 Category: Science Tags: News & Opinion Source Type: news

Organoids regenerate human bile ducts
(Source: ScienceNOW)
Source: ScienceNOW - February 18, 2021 Category: Science Authors: Kelly, P. N. Tags: Cell Biology, Medicine, Diseases twis Source Type: news

Cholangiocyte organoids can repair bile ducts after transplantation in the human liver
Organoid technology holds great promise for regenerative medicine but has not yet been applied to humans. We address this challenge using cholangiocyte organoids in the context of cholangiopathies, which represent a key reason for liver transplantation. Using single-cell RNA sequencing, we show that primary human cholangiocytes display transcriptional diversity that is lost in organoid culture. However, cholangiocyte organoids remain plastic and resume their in vivo signatures when transplanted back in the biliary tree. We then utilize a model of cell engraftment in human livers undergoing ex vivo normothermic perfusion to...
Source: ScienceNOW - February 18, 2021 Category: Science Authors: Sampaziotis, F., Muraro, D., Tysoe, O. C., Sawiak, S., Beach, T. E., Godfrey, E. M., Upponi, S. S., Brevini, T., Wesley, B. T., Garcia-Bernardo, J., Mahbubani, K., Canu, G., Gieseck, R., Berntsen, N. L., Mulcahy, V. L., Crick, K., Fear, C., Robinson, S., Tags: Cell Biology, Medicine, Diseases reports Source Type: news

Know the Signs of Rare But Deadly Gall Bladder, Bile Duct Cancers
(Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - February 16, 2021 Category: Cancer & Oncology Tags: Gastroenterology, Hepatology, Oncology, News, Source Type: news

Know the Signs of Rare But Deadly Gall Bladder, Bile Duct Cancers
TUESDAY, Feb. 16, 2021 -- Most people aren't aware of the signs of gallbladder or bile duct cancer, but the Rutgers Cancer Institute of New Jersey says they should be. The gallbladder is a small organ connected to the liver by bile ducts. Its job... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - February 16, 2021 Category: General Medicine Source Type: news

Know the Signs of Rare But Deadly Gall Bladder, Bile Duct Cancers
Title: Know the Signs of Rare But Deadly Gall Bladder, Bile Duct CancersCategory: Health NewsCreated: 2/16/2021 12:00:00 AMLast Editorial Review: 2/16/2021 12:00:00 AM (Source: MedicineNet Cancer General)
Source: MedicineNet Cancer General - February 16, 2021 Category: Cancer & Oncology Source Type: news

Pandemic-Related Delays in Removing Intraductal Bile Duct Stents Can Be Harmful Pandemic-Related Delays in Removing Intraductal Bile Duct Stents Can Be Harmful
Priority should be given to timely removal of stents following recovery in patients who undergo endoscopic retrograde cholangiopancreatography with biliary stent placement, according to UK researchers.Reuters Health Information (Source: Medscape Gastroenterology Headlines)
Source: Medscape Gastroenterology Headlines - February 12, 2021 Category: Gastroenterology Tags: Gastroenterology News Source Type: news

What Is the Function of Bile?
Title: What Is the Function of Bile?Category: Diseases and ConditionsCreated: 2/2/2021 12:00:00 AMLast Editorial Review: 2/2/2021 12:00:00 AM (Source: MedicineNet Digestion General)
Source: MedicineNet Digestion General - February 2, 2021 Category: Nutrition Source Type: news

Bile acids may play previously unknown role in Parkinson's
(Van Andel Research Institute) What does bile acid production in the digestive tract have to do with Parkinson's disease? Quite a lot, according to a sweeping new analysis published in the journal Metabolites. The findings reveal that changes in the gut microbiome -- the rich population of helpful microbes that call the digestive tract home -- may in turn alter bile acid production by favoring synthesis of toxic forms of the acids. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 2, 2021 Category: International Medicine & Public Health Source Type: news

Elobixibat: A Novel Treatment for Chronic Constipation Elobixibat: A Novel Treatment for Chronic Constipation
Elobixibat, a novel ileal bile acid transport inhibitor, appears to be a safe and effective treatment for chronic constipation.Alimentary Pharmacology & Therapeutics (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - January 27, 2021 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

Albireo Announces U.S. FDA Acceptance of New Drug Application for Odevixibat
BOSTON, Jan. 25, 2021 (GLOBE NEWSWIRE) -- Albireo Pharma, Inc. (Nasdaq: ALBO), a clinical-stage rare liver disease company developing novel bile acid modulators, today announced that the U.S. Food and Drug... (Source: Drugs.com - New Drug Applications)
Source: Drugs.com - New Drug Applications - January 25, 2021 Category: Drugs & Pharmacology Source Type: news

What Is the Common Bile Duct
? (Source: eMedicineHealth.com)
Source: eMedicineHealth.com - January 11, 2021 Category: General Medicine Source Type: news

Albireo Submits for U.S. FDA and EMA Product Approval of Once-Daily Odevixibat for PFIC
BOSTON, Dec. 08, 2020 (GLOBE NEWSWIRE) -- Albireo Pharma, Inc. (Nasdaq: ALBO), a clinical-stage rare liver disease company developing novel bile acid modulators, today announced it has submitted a New Drug Application (NDA) to... (Source: Drugs.com - New Drug Applications)
Source: Drugs.com - New Drug Applications - December 8, 2020 Category: Drugs & Pharmacology Source Type: news

GLIMMER of Hope for Itch in Primary Biliary Cholangitis GLIMMER of Hope for Itch in Primary Biliary Cholangitis
Linerixibat, an ileal sodium-dependent bile acid transporter inhibitor, improved more than itch for patients with primary biliary cholangitis, despite a notable placebo effect, in the GLIMMER trial.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - November 14, 2020 Category: Consumer Health News Tags: Gastroenterology News Source Type: news

Dems make it increasingly clear they CAN’T win elections and enact their left-wing policies without cheating and rigging the system
(Natural News) If we still lived in colonial times, the modern Democratic Party would be viewed with as much bile and venom as our founders viewed the English crown, because King George was the same kind of authoritarian who ruled and lorded over his subjects instead of governing via the will of the people. Democrats’... (Source: NaturalNews.com)
Source: NaturalNews.com - September 23, 2020 Category: Consumer Health News Source Type: news

How Cancer Shaped Justice Ruth Bader Ginsburg ’s Life and Work
The name Ruth Bader Ginsburg became almost synonymous with strength and stamina as she rose to prominence in judicial and feminist circles throughout her long career. Famously nicknamed the Notorious RBG and known for her grueling fitness regimen, the late Supreme Court justice also struggled with cancer and other health issues for the better part of her time on the bench — culminating with her death on Sept. 18 at the age of 87 of complications from metastatic pancreatic cancer. Ginsburg’s health issues became public in 1999, six years after her appointment to the Supreme Court, when she had surgery for early-...
Source: TIME: Health - September 19, 2020 Category: Consumer Health News Authors: Jamie Ducharme Tags: Uncategorized Cancer healthytime remembrance Source Type: news

Fluorescent Cholangiography Could Prevent Bile Duct Injury During Laparoscopic Cholecystectomy Fluorescent Cholangiography Could Prevent Bile Duct Injury During Laparoscopic Cholecystectomy
Fluorescent cholangiography during laparoscopic cholecystectomy could prevent bile duct injury by improving visualization of biliary anatomy, according to a new review.Reuters Health Information (Source: Medscape General Surgery Headlines)
Source: Medscape General Surgery Headlines - September 8, 2020 Category: Surgery Tags: Gastroenterology News Source Type: news

Strides Pharma gets USFDA nod for Ursodiol tablets, a liver disease treatment drug
Strides Pharma Science gets an approval from the USFDA to market Ursodiol tablets used for treating primary biliary cirrhosis, a progressive disease of the liver caused by a buildup of bile within the liver. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - August 20, 2020 Category: Pharmaceuticals Source Type: news

Saved by the Saxons! The disgusting 10th-century potion that could beat superbugs
Made from cow ’s bile, garlic and onions, Bald’s eyesalve was meant to cure styes, but scientists believe it could deal with antibiotic-resistant bacterial infectionsName:Bald ’s eyesalve.Age: 1,000 years old.Continue reading... (Source: Guardian Unlimited Science)
Source: Guardian Unlimited Science - July 29, 2020 Category: Science Tags: Medical research MRSA and superbugs Science Alternative medicine Life and style Source Type: news

Safe Cholecystectomy Practice Guideline and Consensus Safe Cholecystectomy Practice Guideline and Consensus
This article provides evidenced-based, consensus recommendations for safe cholecystectomy and prevention of bile duct injury.Annals of Surgery (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - July 21, 2020 Category: Consumer Health News Tags: General Surgery Journal Article Source Type: news

Scientists discover a new mechanism controlling liver cancer development
This study, published in PNAS, shows that the PPARα protein, when blocked, dramatically reduces the impact and progression of cholangiocarcinoma (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 1, 2020 Category: Cancer & Oncology Source Type: news

Researchers discover unknown consumer base for unsustainable bear product use
(San Diego Zoo Global) A team of researchers led by San Diego Zoo Global made an unexpected discovery: the use of bear bile and body parts in traditional remedies consumed by new and pregnant mothers. The use of traditional medicines derived from bear bile and gallbladders by young and expecting mothers for ailments related to pregnancy had not been previously documented. With populations of wildlife -- including bears -- in decline across Southeast Asia, understanding this large consumer base could inform conservation efforts in the region. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 29, 2020 Category: International Medicine & Public Health Source Type: news

Bicycle handlebar injury in a child resulting in complex liver laceration with massive bleeding and bile leakage: a case report - Grosek J, Čebron, Janež J, Tomažič A.
We present a case of severe liver laceration wi... (Source: SafetyLit)
Source: SafetyLit - June 24, 2020 Category: International Medicine & Public Health Tags: Age: Infants and Children Source Type: news

New clues on how lipid emulsions prevent liver disease in preterm babies
(Baylor College of Medicine) New evidence links the microbiome and gut bile acids to lipid emulsion prevention of liver disease in preterm babies. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 4, 2020 Category: International Medicine & Public Health Source Type: news

Ivosidenib Promising Against Refractory Bile Duct Cancer Ivosidenib Promising Against Refractory Bile Duct Cancer
Ivosidenib improved progression-free survival in patients with previously treated isocitrate dehydrogenase 1 (IDH1)-mutant cholangiocarcinoma in a phase 3 placebo-controlled trial.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - May 26, 2020 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Analysis of factors related to prognosis and death of fish bile poisoning in China: a retrospective study - Yan W, Wang Z, Lu S, Li J, Chen Q, Wang L, Chen S, Wang X, Xiong K, Yan J.
Fish bile has long been considered to have therapeutic benefits in folk medicine in some Asian countries. However, poisoning incidents and even death sporadically occurred when people consumed fish bile. Herein, we summarize the main characteristics of fis... (Source: SafetyLit)
Source: SafetyLit - May 25, 2020 Category: International Medicine & Public Health Tags: Home and Consumer Product Safety Source Type: news

Dr. Sanjay Gupta: If the United States were my patient
For a moment, think of the United States as a human body. Full of heart and mind. Bile and blood. Muscle and fat. Like any body, it has its strengths and weaknesses, and must consistently work to prevent disease and optimize function. It needs to nourish itself, exercise, and take care of its physical and mental health. (Source: CNN.com - Health)
Source: CNN.com - Health - May 17, 2020 Category: Consumer Health News Source Type: news

FDA Approves First Targeted Drug for Bile Duct Cancer FDA Approves First Targeted Drug for Bile Duct Cancer
A subgroup of patients with advanced cholangiocarcinma who have tumors with FGFR2 abnormalities have a new treatment option -- the oral targeted therapy pemigatinib.News Alerts (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - April 20, 2020 Category: Consumer Health News Tags: Hematology-Oncology News Alert Source Type: news

FDA Approves First Targeted Treatment for Patients with Cholangiocarcinoma, a Cancer of Bile Ducts
FDA has approved Pemazyre (pemigatinib), the first treatment approved for adults with certain types of previously treated, advanced cholangiocarcinoma, a rare form of cancer that forms in bile ducts. (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - April 17, 2020 Category: Drugs & Pharmacology Authors: FDA Source Type: news

' Minor' Iatrogenic Bile Duct Injuries Can Have Major Consequences'Minor' Iatrogenic Bile Duct Injuries Can Have Major Consequences
Bile duct injuries that are considered'minor,'that is, those of Strasberg grades A to D, can nonetheless result in substantial long-term morbidity and costs, according to a new study from the UK.Reuters Health Information (Source: Medscape General Surgery Headlines)
Source: Medscape General Surgery Headlines - April 17, 2020 Category: Surgery Tags: General Surgery News Source Type: news

Ludwig MSK study reveals bile metabolite of gut microbes boosts immune cells
(Ludwig Institute for Cancer Research) A Ludwig Cancer Research study has discovered a novel means by which bacterial colonies in the small intestine support the generation of regulatory T cells--immune cells that suppress autoimmune reactions and inflammation. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 15, 2020 Category: International Medicine & Public Health Source Type: news

Drug used for liver disease also affects C. diff life cycle, reduces inflammation in mice
(North Carolina State University) Researchers have found that a commonly used drug made from secondary bile acids can affect the life cycle of Clostridioides difficile (C. diff) in vitro and reduce the inflammatory response to C. diff in mice. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - March 30, 2020 Category: Biology Source Type: news

Chinese vs. Western Governance: The case of COVID-19
Emergency room nurses wear face masks at Second People's Hospital of Shenzhen in China. Credit: Man Yi/ UN News By Martin JacquesLONDON, Mar 26 2020 (IPS) During January the onslaught in the Western media, notably the US and the UK, against the Chinese government’s handling of the Covid-19 epidemic, was merciless. The Chinese government stood accused of an inhumane attitude towards its people, secrecy, a cover-up, and an overwhelming concern for its own survival above all other considerations. The actual evidence was thin bordering at times on the threadbare but this made little difference to the venom and bile of th...
Source: IPS Inter Press Service - Health - March 26, 2020 Category: International Medicine & Public Health Authors: Martin Jacques Tags: Democracy Global Headlines Health Coronavirus Source Type: news

Bile duct cancer: Mayo Clinic Radio Health Minute
In this Mayo Clinic Radio Health Minute, Dr. Bret Petersen, a Mayo Clinic?gastroenterologist, discusses bile duct cancer. To listen, click the link below. Bile duct cancer (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - March 19, 2020 Category: Databases & Libraries Source Type: news

Gravely ill mother diagnosed with bile duct cancer gets new lease of life from revolutionary drug
Mother-of-four Kadiatou Diallo, who is originally from Guinea in West Africa and has lived in the UK for nearly 20 years, is feeling better than she has done in years as a result of taking the new drug. (Source: the Mail online | Health)
Source: the Mail online | Health - March 14, 2020 Category: Consumer Health News Source Type: news

The incidence of drugs in fatally injured drivers - Woodhouse EJ.
Methods for the collection of blood, urine, bile and alcohol washes of face and fingers from fatally injured drivers have been developed. Specimens were supplied by coroners and medical examiners from fatally injured drivers. Seven hundred and ten were ret... (Source: SafetyLit)
Source: SafetyLit - February 29, 2020 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

New bile discovery will rewrite textbooks
(Michigan State University) Forget what you know about bile because that's about to change, thanks to a new discovery made by Michigan State University and published in the current issue of Nature. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - February 26, 2020 Category: Biology Source Type: news

Ulcerative colitis: bacteria findings raise hopes for new treatment
Sufferers found to have low levels of gut microbes that convert bile acids into other substancesHopes of developing a new treatment for ulcerative colitis have been raised by research suggesting the condition may be linked to low levels of certain bacteria in the gut.Ulcerative colitis is a long-term condition in whichthe colon becomes inflamed. Accordingto the NHS, it is thought to be an autoimmune disease and affects one in every 420 people in the UK. Sufferers need to empty their bowels frequently, develop ulcers in their colon and have recurring bouts of diarrhoea with blood and pus in the faeces.Continue reading... (S...
Source: Guardian Unlimited Science - February 25, 2020 Category: Science Authors: Nicola Davis Tags: Digestive disorders Science Health & wellbeing Life and style Society Source Type: news

Bile duct cancer treatment potential boost from tailored medication -- study
(University of Birmingham) Treatment of patients suffering from bile duct cancer could be improved by tailoring medication to the levels of a key protein in people with the disease, according to new research. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 14, 2020 Category: Cancer & Oncology Source Type: news

'Genetic rewiring' drives cancer's drug resistance
(Institute of Cancer Research) Tiny RNA molecule rewires signalling network in bile duct cancer. Drugs to block RNA could overcome cancer's drug resistance. Findings announced to coincide with Bile Duct Cancer Awareness Day. Results could be applicable in other cancer types and have wider benefit. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 11, 2020 Category: Cancer & Oncology Source Type: news

Wild melancholy: on the historical plausibility of a black bile theory of blood madness, or h æmatomania - Verplaetse J.
Nineteenth-century art historian John Addington Symonds coined the term h æmatomania (blood madness) for the extremely bloodthirsty behaviour of a number of disturbed rulers like Ibrahim II of Ifriqiya (850-902) and Ezzelino da Romano (1194-1259). A... (Source: SafetyLit)
Source: SafetyLit - January 27, 2020 Category: International Medicine & Public Health Tags: Commentary Source Type: news

Study suggests new strategy for treating advanced, progressing bile duct cancer
(Ohio State University Wexner Medical Center) A new study led by researchers at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC - James) shows how resistance to a promising targeted drug develops in patients with a rare, lethal cancer of the bile ducts called cholangiocarcinoma. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 14, 2020 Category: Cancer & Oncology Source Type: news

Epistane, an anabolic steroid used for recreational purposes, causes cholestasis with elevated levels of cholic acid conjugates, by upregulating bile acid synthesis (CYP8B1) and cross-talking with nuclear receptors in human hepatocytes - Petrov PD, Fern ández-Murga L, Conde I, Martínez-Sena T, Guzmán C, Castell JV, Jover R.
Anabolic-androgenic steroids are testosterone derivatives, used by body-builders to increase muscle mass. Epistane (EPI) is an orally administered 17 α-alkylated testosterone derivative with 2a-3a epithio ring. We identified four individuals who, after EPI... (Source: SafetyLit)
Source: SafetyLit - January 4, 2020 Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news