Pre-eclamptic foetal programming predisposes offspring to hepatic steatosis via DNA methylation

CONCLUSION: These findings suggest a methylation-mediated epigenetic mechanism for PE-induced intergenerational lipid accumulation, impaired energy balance and obesity in offspring, and indicate the potential benefits of early interventions in offspring exposed to maternal PE to reduce their susceptibility to metabolic disorder in their later life.PMID:38648899 | DOI:10.1016/j.bbadis.2024.167189

Source: Biochimica et Biophysica Acta - April 22, 2024 Category: Biochemistry Authors: Huixi Chen Sisi Luo Xiuyu Deng Sisi Li Yiting Mao Jing Yan Yi Cheng Xia Liu Jiexue Pan Hefeng Huang Source Type: research