METTL3 orchestrates glycolysis by stabilizing the c-Myc/WDR5 complex in triple-negative breast cancer

CONCLUSION: METTL3 binds to the c-Myc/WDR5 complex and promotes glycolysis, which plays a powerful role in promoting TNBC progression. Our findings further broaden our understanding of the role and mechanism of action of METTL3, and may open up new therapeutic avenues for effective treatment of TNBC with high c-Myc expression.PMID:38547933 | DOI:10.1016/j.bbamcr.2024.119716

Source: Biochimica et Biophysica Acta - March 28, 2024 Category: Biochemistry Authors: Xiao-Ning Yuan You-Cheng Shao Xiao-Qing Guan Qin Liu Meng-Fei Chu Ze-Lin Yang Hui Li Sai Zhao Yi-Hao Tian Jing-Wei Zhang Lei Wei Source Type: research