Regulation of VEGF gene expression by bisacridine derivative through promoter i-motif for cancer treatment

CONCLUSION: B09 could specifically regulate VEGF gene expression, possibly through interacting with promoter i-motif structure. As a lead compound, B09 could be further developed for innovative anti-cancer agent targeting VEGF.PMID:38685534 | DOI:10.1016/j.bbagen.2024.130631

Source: Biochimica et Biophysica Acta - April 30, 2024 Category: Biochemistry Authors: Jing Wang Siyi Wang Jiahui Zhang Dongsheng Ji Zhi-Shu Huang Ding Li Source Type: research