Epidemiology of Treponema pallidum, Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, and herpes simplex virus type 2 among female sex workers in the Middle East and North Africa: systematic review and meta-analytics.
Conclusions: STI infection levels among FSWs in MENA are considerable, supporting a key role for commercial heterosexual sex networks in transmission dynamics, and highlighting the health needs of this neglected and vulnerable population. Syphilis prevalence in FSWs appears to have been declining for at least three decades. Gaps in evidence persist for multiple countries. PMID: 31360448 [PubMed - in process] (Source: Herpes)
Source: Herpes - July 31, 2019 Category: Infectious Diseases Authors: Chemaitelly H, Weiss HA, Smolak A, Majed E, Abu-Raddad LJ Tags: J Glob Health Source Type: research

Cell therapy for spinal cord injury using induced pluripotent stem cells.
Abstract For the past few decades, spinal cord injury (SCI) has been believed to be an incurable traumatic condition, but with recent developments in stem cell biology, the field of regenerative medicine has gained hopeful momentum in the development of a treatment for this challenging pathology. Among the treatment candidates, transplantation of neural precursor cells has gained remarkable attention as a reasonable therapeutic intervention to replace the damaged central nervous system cells and promote functional recovery. Here, we highlight transplantation therapy techniques using induced pluripotent stem cells ...
Source: Herpes - June 28, 2019 Category: Infectious Diseases Authors: Nagoshi N, Tsuji O, Nakamura M, Okano H Tags: Regen Ther Source Type: research

Treatment of Viral Infections During Pregnancy.
This article reviews the treatment of herpes simplex virus, cytomegalovirus, hepatitis B and C viruses, and human immunodeficiency virus during pregnancy. PMID: 31010558 [PubMed - in process] (Source: Herpes)
Source: Herpes - April 25, 2019 Category: Infectious Diseases Authors: Rogan SC, Beigi RH Tags: Clin Perinatol Source Type: research

Chimeric Antigen Receptor T Cell Bearing Herpes Virus Entry Mediator Co-stimulatory Signal Domain Exhibits High Functional Potency.
Abstract Chimeric antigen receptor (CAR) is a hybrid molecule consisting of an antigen-binding domain and a signal transduction domain. The artificial T cells expressing CAR (CAR-T cells) are expected to be a useful tool for treatment of various diseases, such as cancer. The addition of a co-stimulatory signal domain (CSSD) to CAR is shown to be critical for modulating CAR-T cell activities. However, the interplay among types of CSSDs, effector functions, and characteristics of CAR-T cells is largely unknown. To elucidate the interplay, we analyzed effector functions, differentiation to memory T cell sub...
Source: Herpes - April 25, 2019 Category: Infectious Diseases Authors: Nunoya JI, Masuda M, Ye C, Su L Tags: Mol Ther Oncolytics Source Type: research

Oncolytic Herpes Simplex Virus and PI3K Inhibitor BKM120 Synergize to Promote Killing of Prostate Cancer Stem-like Cells.
Abstract Novel therapies to override chemo-radiation resistance in prostate cancer (PCa) are needed. Prostate cancer sphere-forming cells (PCSCs) (also termed prostate cancer stem-like cells) likely participate in tumor progression and recurrence, and they are important therapeutic targets. We established PCSC-enriched spheres by culturing human (DU145) and murine (TRAMP-C2) PCa cells in growth factor-defined serum-free medium, and we characterized stem-like properties of clonogenicity and tumorigenicity. The efficacy of two different oncolytic herpes simplex viruses (oHSVs) (G47Δ and MG18L) in PCSCs was tes...
Source: Herpes - April 25, 2019 Category: Infectious Diseases Authors: Wang L, Ning J, Wakimoto H, Wu S, Wu CL, Humphrey MR, Rabkin SD, Martuza RL Tags: Mol Ther Oncolytics Source Type: research

Herpes Virus Infections Other than Cytomegalovirus in the Recipients of Hematopoietic Stem Cell Transplantation.
Abstract This review discusses the epidemiologic and clinical aspects of herpes viruses other than cytomegalovirus in patients who have undergone hematopoietic stem cell transplantation. PMID: 31005137 [PubMed - in process] (Source: Herpes)
Source: Herpes - April 22, 2019 Category: Infectious Diseases Authors: Dadwal SS Tags: Infect Dis Clin North Am Source Type: research

Predictors of Perinatal HIV Transmission Among Women Without Prior Antiretroviral Therapy in a Resource-Limited Setting: The Breastfeeding, Antiretrovirals and Nutrition Study.
CONCLUSIONS: These findings confirm that lowering maternal HIV viral load is most important in preventing perinatal MTCT and support efforts to address food shortage, STI and tuberculosis prevention, while informing programs to improve ART coverage in pregnancy. PMID: 30985546 [PubMed - in process] (Source: Herpes)
Source: Herpes - April 17, 2019 Category: Infectious Diseases Authors: Ewing AC, Ellington SR, Wiener JB, Chasela CS, Tegha G, Nelson JAE, Jamieson DJ, van der Horst C, Kourtis AP, BAN Study Team Tags: Pediatr Infect Dis J Source Type: research

Sexually Transmitted Diseases in the Emergency Department.
Abstract Sexually transmitted diseases (STDs) continue to be underrecognized leading to devastating health and economic consequences. Emergency clinicians play an important role in diagnosing and managing STDs and in improving health care outcomes for both the patient and their partners. In addition, antibiotic resistance and emerging infections continue to challenge providers in clinical practice. This review focuses on the cause, history, physical examination, diagnostic studies, and treatment strategies for bacterial vaginosis, chlamydia, genital herpes, gonorrhea, human papillomavirus, granuloma inguinale, Lym...
Source: Herpes - April 5, 2019 Category: Infectious Diseases Authors: Pfennig CL Tags: Emerg Med Clin North Am Source Type: research

The Role of T Cells in Herpes Stromal Keratitis.
Abstract The blinding inflammatory lesion stromal keratitis (SK), which occurs in some patients in response to ocular herpes simplex virus (HSV) infection, represents mainly an immune cell mediated inflammatory response to the virus infection. The principal orchestrators of the immunopathological lesions are T cells although additional events participate that include the extent of recruitment of non-lymphoid cells, the extent of neoangiogenesis, and the extent of damage to nerve function. This review focuses on evidence that the balance of the functional subsets of T cells has a major impact on lesion severity and...
Source: Herpes - April 5, 2019 Category: Infectious Diseases Authors: Rajasagi NK, Rouse BT Tags: Front Immunol Source Type: research

Severe Facial Herpes Vegetans and Viremia in NFKB2-Deficient Common Variable Immunodeficiency.
We report a patient with early-onset CVID due to an autosomal dominant loss-of-function mutation in NFKB2 who developed a severe herpes vegetans cutaneous infection as well as concurrent herpes simplex virus viremia. The case highlights features of CVID, unique aspects of NF-κB2 deficiency including susceptibility to herpesvirus infections, the detection of neutralizing anticytokine antibodies, and the complexity of medical management of patients with a PIDD that can be aided by a known genetic diagnosis. PMID: 30941333 [PubMed] (Source: Herpes)
Source: Herpes - April 5, 2019 Category: Infectious Diseases Authors: Parsons K, Cipriano SD, Rosen LB, Browne SK, Walter JE, Stone BL, Keeshin S, Chen K Tags: Front Pediatr Source Type: research

Post-shingles granulomatous dermatosis related to anti-programmed cell death 1.
Abstract The most recent progress in the oncology field has led to a paradigm shift in the management of cancer with the tsunami of immune checkpoint inhibitors that are associated with a particular pattern of immunological adverse events. This is a case of a 54-year-old woman that demonstrated a granulomatous reaction in the same dermatomal distribution of a previously treated shingles infection during treatment with an anti-programmed death 1 agent (pembrolizumab) for a newly diagnosed stage IV Hodgkin lymphoma. The purpose of this case is to increase the awareness of oncologists dealing with a new pat...
Source: Herpes - April 5, 2019 Category: Infectious Diseases Authors: Assi T, Danu A, Mateus C, Robert C, Michot JM, Ibrahim T, Lazarovici J, Ghez D, Rossignol J, Dartigues P, Terroir-Cassou-Mounat M, Ribrag V Tags: Immunotherapy Source Type: research

Pulsed immune reconstitution therapy in multiple sclerosis.
Abstract Whereas drugs used for maintenance/escalation therapy do not maintain their beneficial effect after cessation of therapy, some new highly effective therapies can show prolonged treatment effects after a short treatment course. Such therapies have been named pulsed immune reconstitution therapies or pulsed immunosuppressive therapies, and typical representatives are alemtuzumab and cladribine. Autologous haematopoietic stem cell transplantation could be considered as the strongest immune reconstitution therapy. Both alemtuzumab and cladribine induce depletion of lymphocytes, and a common mechanism of actio...
Source: Herpes - April 5, 2019 Category: Infectious Diseases Authors: Sorensen PS, Sellebjerg F Tags: Ther Adv Neurol Disord Source Type: research

Correlation between herpes simplex virus neutralizing antibody titers determined by ELVIS cell and traditional plaque reduction assays.
Abstract Preventive viral vaccine efficacy trials require large-scale sample analysis to quantitate immune responses and their correlation with infection outcomes. Traditional plaque reduction assays measure a functionally important form of humoral immunity, neutralizing antibody titer. These assays, however, are time-consuming and laborious. We previously developed a higher throughput assay of neutralizing antibody to herpes simplex viruses 1 and 2 (Blevins et al., PLOS ONE, 10(12), e0144738) using the enzyme-linked virus inducible system (ELVIS) cell line; this cell line produces β-galactosidase in response...
Source: Herpes - April 5, 2019 Category: Infectious Diseases Authors: Blevins TP, Yu Y, Belshe RB, Bellamy AR, Morrison LA Tags: PLoS One Source Type: research

Dermatitis artefacta: self-inflicted genital injury.
Conclusion: Dermatitis artefacta is a factitious disorder that involves falsification of psychological or physical signs or symptoms caused entirely by the patients themselves, in a clear state of consciousness, in order to play the role of a sick person. The correlation of anamnestic data and clinical and para-clinical exams was essential for the diagnosis of dermatitis artefacta in this case. To the best of our knowledge, pyoderma gangrenosum-like lesions have never been reported in a patient with dermatitis artefacta. Herein, we describe a rare case report of self-inflicted genital injury in a 52-year-old male. PMI...
Source: Herpes - April 4, 2019 Category: Infectious Diseases Authors: Olisova OY, Snarskaya ES, Smirnova LM, Grabovskaya O, Anpilogova EM Tags: Int Med Case Rep J Source Type: research

A nasal hypertrophic lesion as a presentation of herpes simplex virus.
Abstract Herpes simplex virus type 1 and type 2 (HSV-1 & HSV-2) are one of the leading causes of ulcer and blister lesions worldwide. These infections are latent with recurrences but many people may have a seropositive antibody yet remain asymptomatic. Although HSV presenting with hypertrophic lesions have been reported in the literature at urogenital, lung, and conjunctival sites, we describe a case of a mass lesion in the nasal cavity of a 46 year-old female with a history of human immunodeficiency virus (HIV). The patient presented initially with nasal congestion and subsequently developed facial edema. The...
Source: Herpes - April 4, 2019 Category: Infectious Diseases Authors: Chiu CY, Randhawa G, Nada K, Tomczak E, Feinstein A, Hennessey K Tags: IDCases Source Type: research

Case of herpes zoster complicated by diaphragmatic paralysis.
PMID: 30938463 [PubMed - as supplied by publisher] (Source: Herpes)
Source: Herpes - April 2, 2019 Category: Infectious Diseases Authors: Waki Y, Nobeyama Y, Fukuchi O, Mukai T, Takagi M, Asahina A Tags: J Dermatol Source Type: research

Fifty years in search of selective antiviral drugs.
Abstract Fifty years of research (1968-2018) towards the identification of selective antiviral drugs have been primarily focused on antiviral compounds active against DNA viruses [i.e. herpes simplex virus (HSV), varicella-zoster virus (VZV), cytomegalovirus (CMV), hepatitis B virus (HBV)] and retroviruses [i.e. human immunodeficiency virus (HIV)]. For the treatment of HSV infections the aminoacyl esters of acyclovir were designed, one of which (the valine ester valacyclovir) became the successor of acyclovir in the treatment of HSV and VZV infections. BVDU (Brivudin) still stands out as the most effective among t...
Source: Herpes - April 2, 2019 Category: Infectious Diseases Authors: De Clercq E Tags: J Med Chem Source Type: research

Safety of cladribine tablets in the treatment of patients with multiple sclerosis: An integrated analysis.
Abstract BACKGROUND: Treating patients with relapsing multiple sclerosis (MS) with cladribine tablets (two times 4 or 5 days of treatment each year for 2 years) results in long-lasting efficacy, with continued stability in many patients for 4 or more years. Safety and tolerability outcomes from individual clinical studies with cladribine tablets have been reported previously. OBJECTIVE: Report safety data from an integrated analysis of clinical trials and follow-up in patients with MS to further characterize the safety profile of cladribine tablets. METHODS: Data for patients treated with cladribine tabl...
Source: Herpes - March 21, 2019 Category: Infectious Diseases Authors: Cook S, Leist T, Comi G, Montalban X, Giovannoni G, Nolting A, Hicking C, Galazka A, Sylvester E Tags: Mult Scler Relat Disord Source Type: research

Circumcision to prevent HIV and other sexually transmitted infections in men who have sex with men: a systematic review and meta-analysis of global data.
Abstract BACKGROUND: Men who have sex with men (MSM) are disproportionately affected by HIV and other sexually transmitted infections (STIs) worldwide. Previous reviews investigating the role of circumcision in preventing HIV and other STIs among MSM were inconclusive. Many new studies have emerged in the past decade. To inform global prevention strategies for HIV and other STIs among MSM, we reviewed all available evidence on the associations between circumcision and HIV and other STIs among MSM. METHODS: In this systematic review and meta-analysis, we searched PubMed, Web of Science, BioMed Central, Scopus,...
Source: Herpes - March 19, 2019 Category: Infectious Diseases Authors: Yuan T, Fitzpatrick T, Ko NY, Cai Y, Chen Y, Zhao J, Li L, Xu J, Gu J, Li J, Hao C, Yang Z, Cai W, Cheng CY, Luo Z, Zhang K, Wu G, Meng X, Grulich AE, Hao Y, Zou H Tags: Lancet Glob Health Source Type: research

Varicella-zoster virus as a causative agent of acute retinal necrosis in younger patients.
CONCLUSIONS: This study demonstrates that VZV is also a common causative virus for ARN in younger patients. Considering this finding, a systemic antiviral treatment protocol should be immediately changed to intravenous ganciclovir when the patient does not respond to acyclovir before determining the causative virus, especially in younger patients. PMID: 30855346 [PubMed - in process] (Source: Herpes)
Source: Herpes - March 12, 2019 Category: Infectious Diseases Authors: Xu HY, Li MD, Ye JJ, Zhao C, Hu YT, Di Y Tags: Chin Med J (Engl) Source Type: research

Characterizing the transitioning epidemiology of herpes simplex virus type 1 in the USA: model-based predictions.
CONCLUSION: HSV-1 epidemiology is undergoing a remarkable transition in the US, with less exposure in childhood and more in adulthood, and less oral but more genital acquisition. HSV-1 will persist as a widely prevalent infection, with ever-increasing genital disease burden. PMID: 30853029 [PubMed - in process] (Source: Herpes)
Source: Herpes - March 11, 2019 Category: Infectious Diseases Authors: Ayoub HH, Chemaitelly H, Abu-Raddad LJ Tags: BMC Med Source Type: research

When an "Active Call" can be a "Wake-up Call".
When an "Active Call" can be a "Wake-up Call". Aging Clin Exp Res. 2019 Mar 11;: Authors: Maggi S, Michel JP Abstract PMID: 30854600 [PubMed - as supplied by publisher] (Source: Herpes)
Source: Herpes - March 11, 2019 Category: Infectious Diseases Authors: Maggi S, Michel JP Tags: Aging Clin Exp Res Source Type: research

In Silico and Molecular Docking Studies That Address Viral (Std) Transmission Points.
Abstract Sexually transmitted diseases (STDs) refer to a variety of clinical syndromes and infections caused by pathogens that can be acquired and transmitted through sexual activity. Among STDs widely reported in the literature, viral sexual diseases have been increasing in number of cases globally. This emphasizes the need for prevention and treatment. Among the methods widely used in drug planning are computer-aided drug design (CADD) studies and molecular docking which has the objective of investigating molecular interactions between two molecules to better understand the three -dimensional structural characte...
Source: Herpes - March 11, 2019 Category: Infectious Diseases Authors: Monteiro AFM, de Oliveira Viana J, Muratov E, Scotti MT, Scotti L Tags: Curr Protein Pept Sci Source Type: research

Cellular Requirements for Sensing and Elimination of Incoming HSV-1 DNA and Capsids.
In this study, we investigate the cellular requirements for sensing and degradation of incoming viral DNA and capsids during herpes simplex virus type 1 (HSV-1) infections. Using click chemistry labeling of the viral genome, we found that HSV-1 DNA was released from a subset of capsids into the cytosol early in infection. By next-generation sequencing of cyclic GMP-AMP (cGAMP) synthase (cGAS)-bound DNA from HSV-1-infected cells, we show that HSV-1 DNA was bound by the cytosolic DNA sensor cGAS. Activation of cGAS enzymatic activity by viral DNA did not require proteasomal activity, indicating that viral DNA release into th...
Source: Herpes - March 11, 2019 Category: Infectious Diseases Authors: Sun C, Luecke S, Bodda C, Jønsson KL, Cai Y, Zhang BC, Jensen SB, Nordentoft I, Jensen JM, Jakobsen MR, Paludan SR Tags: J Interferon Cytokine Res Source Type: research

Molecular analyses and phylogeny of the herpes simplex virus 2 US9 and glycoproteins gE/gI obtained from infected subjects during the Herpevac Trial for Women.
Abstract Herpes simplex virus 2 (HSV-2) is a large double-stranded DNA virus that causes genital sores when spread by sexual contact and is a principal cause of viral encephalitis in newborns and infants. Viral glycoproteins enable virion entry into and spread between cells, making glycoproteins a prime target for vaccine development. A truncated glycoprotein D2 (gD2) vaccine candidate, recently tested in the phase 3 Herpevac Trial for Women, did not prevent HSV-2 infection in initially seronegative women. Some women who became infected experienced multiple recurrences during the trial. The HSV US7, US8, and US9 g...
Source: Herpes - March 9, 2019 Category: Infectious Diseases Authors: Rowe KL, Minaya MA, Belshe RB, Morrison LA Tags: PLoS One Source Type: research

Vaccine Prevention of Herpes Zoster in Organ Transplant Recipients: A Busy Intersection of Immune Responses to Foreign Antigens.
PMID: 30843045 [PubMed - as supplied by publisher] (Source: Herpes)
Source: Herpes - March 7, 2019 Category: Infectious Diseases Authors: Miller G Tags: Clin Infect Dis Source Type: research

Immunogenicity and Safety of the Adjuvanted Recombinant Zoster Vaccine in Chronically Immunosuppressed Adults Following Renal Transplant: a Phase III, Randomized Clinical Trial.
CONCLUSIONS: RZV was immunogenic in chronically immunosuppressed RT recipients. Immunogenicity persisted through 12M post-vaccination. No safety concerns arose. PMID: 30843046 [PubMed - as supplied by publisher] (Source: Herpes)
Source: Herpes - March 7, 2019 Category: Infectious Diseases Authors: Vink P, Ramon Torrell JM, Sanchez Fructuoso A, Kim SJ, Kim SI, Zaltzman J, Ortiz F, Campistol Plana JM, Fernandez Rodriguez AM, Rebollo Rodrigo H, Campins Marti M, Perez R, González Roncero FM, Kumar D, Chiang YJ, Doucette K, Pipeleers L, Agüera Morales Tags: Clin Infect Dis Source Type: research

The Combination of Dimorphandra gardneriana Galactomannan and Mangiferin Inhibits Herpes Simplex and Poliovirus.
CONCLUSION: These results suggested that the DgGmM inhibited HSV-1 and PV-1 replication, with low cytotoxicity and high selectivity and, therefore, represents a potential candidate for further studies on the control of herpes and polio infections. PMID: 30848197 [PubMed - as supplied by publisher] (Source: Herpes)
Source: Herpes - March 7, 2019 Category: Infectious Diseases Authors: Rechenchoski DZ, Samensari NL, Faccin-Galhardi LC, de Almeida RR, Cunha AP, Ricardo NMPS, Nozawa C, Linhares REC Tags: Curr Pharm Biotechnol Source Type: research

Maintaining Breastfeeding During Severe Infant and Maternal HSV-1 Infection: A Case Report.
CONCLUSIONS:: Neonatal herpes infection is a potentially fatal disease and maternal child health professionals should have a high suspicion for any ill-appearing newborn with or without a rash. When a breastfeeding infant and mother become infected with Herpes Simplex Virus type 1, it is the responsibility of the healthcare institution to support lactation and the return to breastfeeding rather than recommend cessation of lactation, which is rarely necessary. A multi-disciplinary evidence-based approach to lactation care is essential to preserve lactation during infant hospitalization. PMID: 30840531 [PubMed - as supp...
Source: Herpes - March 6, 2019 Category: Infectious Diseases Authors: D'Andrea MA, Spatz DL Tags: J Hum Lact Source Type: research

Prevalence of herpes simplex virus-1 in hospitalized adult patients with clinical diagnosis of meningoencephalitis using real-time polymerase chain reaction: A single-center, cross-sectional study.
Conclusion: According to the estimated prevalence of HSV-1 meningoencephalitis in the current study, it seems that the prevalence of HSV-1 meningoencephalitis is not too high in our community; therefore, initial empiric acyclovir therapy is frequently overused. PMID: 30815020 [PubMed] (Source: Herpes)
Source: Herpes - March 5, 2019 Category: Infectious Diseases Authors: Shirani K, Khorvash F, Naeini AE, Valiyan Boroujeni M, Yazdani M Tags: J Res Med Sci Source Type: research

Adenovirus-mediated herpes simplex virus thymidine kinase gene therapy combined with ganciclovir induces hepatoma cell apoptosis.
Abstract The present study aimed to examine the apoptotic effects of adenovirus (ADV)-mediated herpes simplex virus thymidine kinase (ADV-TK) combined with ganciclovir (GCV) in tissues obtained from patients with hepatocellular carcinoma in order to provide a theoretical basis for the development of this gene therapy program. Apoptosis detection was conducted using the terminal deoxynucleotidyl-transferase-mediated dUTP nick end labelling assay and the apoptosis index was compared between the experimental; and control groups. Furthermore, the protein expression levels of caspase-3, B-cell lymphoma-2 (Bcl-2), Bcl-2...
Source: Herpes - February 22, 2019 Category: Infectious Diseases Authors: Zhang H, Qin L, Li C, Jiang J, Sun L, Zhao X, Li N Tags: Exp Ther Med Source Type: research

Screening for Sexually Transmitted Diseases.
This article discusses sexually transmitted infections (STI) screening and focuses on reportable STIs. This includes gonorrhea, chlamydia, syphilis, and human immunodeficiency virus. Hepatitis B and C, trichomonas, and herpes are covered as well. Recommendations are summarized from the various organizations that produce screening recommendations. These screening recommendations only apply to asymptomatic individuals. Once an individual has symptoms, testing becomes diagnostic. It is important to know the prevalence of STIs within your population. If you work in a population with a high prevalence of a specific disease, you...
Source: Herpes - February 3, 2019 Category: Infectious Diseases Authors: Levy SB, Gunta J, Edemekong P Tags: Prim Care Source Type: research

Mouse model of anti-NMDA receptor post-herpes simplex encephalitis.
u J, Chen J Abstract Objective: To develop an endogenous rodent model of postinfectious anti-NMDA receptor (NMDAR) encephalitis. Methods: Six mice were inoculated intranasally with herpes simplex virus (HSV) 1 and subsequently treated with acyclovir for 2 weeks. Serum was collected at 3, 6, and 8 weeks postinoculation and tested for NMDAR antibodies through a cell-based assay. Eight weeks postinoculation, mice were killed and their brains were sectioned and immunostained with antibodies to postsynaptic density (PSD)-95 and NMDARs. Colocalization of hippocampal PSD-95 and NMDAR clusters, representing postsynap...
Source: Herpes - January 31, 2019 Category: Infectious Diseases Authors: Linnoila J, Pulli B, Armangué T, Planagumà J, Narsimhan R, Schob S, Zeller MWG, Dalmau J, Chen J Tags: Neurol Neuroimmunol Neuroinflamm Source Type: research

Acyclovir Unresponsive Herpes Simplex Encephalitis in a child successfully treated with the addition of Foscarnet: Case report.
Abstract Herpes simplex encephalitis (HSE) is the most common cause of sporadic focal encephalitis worldwide. Acyclovir is the treatment of choice of HSE since the 1980s. After the widespread use of acyclovir, HSE related mortality rate had reduced but resistant strains emerged. Acyclovir resistant HSV incidence was reported as about 0.5 % and 3.5 %-10 % in immunocompetent and immunocompromised patients, respectively. Herein, a 12-year-old immunocompetent patient with HSV-1 encephalitis who was successfully treated with combined acyclovir and foscarnet therapy is described. In the case of deteriorating clinical co...
Source: Herpes - January 19, 2019 Category: Infectious Diseases Authors: Gayretli Aydin ZG, Tanir G, Genc Sel C, Tasci Yıldız Y, Aydin Teke T, Kaman A Tags: Arch Argent Pediatr Source Type: research

[Infantile atypical hand-foot-mouth disease with features of eczema herpeticum and acrodermatitis].
We present the case of a 2-year-old child previously diagnosed with atopic dermatitis, who presented with papules and umbilicated vesicles affecting the perioral area and limbs, predominantly in pressure areas, as well as in areas with previous atopic lesions. Although he was clinically diagnosed with herpetic eczema, tests results were negative for herpes virus. However, positive entorovirus polymerase chain reaction results were obtained from the content of a vesicle, a pharyngeal exudate and a stool sample. PMID: 30652458 [PubMed - in process] (Source: Herpes)
Source: Herpes - January 19, 2019 Category: Infectious Diseases Authors: Coronel-Perez IM, Porras-Gonzdlez A, Rodriguez-Rey EM, Croche-Santander B Tags: Arch Argent Pediatr Source Type: research

Incidence and Characteristics of Neonatal Herpes: Comparison of Two Population-Based Data Sources, New York City, 2006-2015.
CONCLUSIONS: Administrative hospital data can be used to measure the incidence of nHSV infection and describe disease burden across population subgroups in jurisdictions where nHSV reporting is not required. However, administrative data may underascertain nHSV case fatality. PMID: 30640862 [PubMed - in process] (Source: Herpes)
Source: Herpes - January 16, 2019 Category: Infectious Diseases Authors: Lao S, Flagg EW, Schillinger JA Tags: Sex Transm Dis Source Type: research

Soft Tissue Disorders of the Mouth.
This article focuses on the identification, etiology, management, and complications of common infectious processes (candidiasis, dental caries, and herpes labialis), inflammatory lesions (sialolithiasis, oral lichen planus, and aphthous ulcer), and benign entities (bony tori and mucocele). PMID: 30454780 [PubMed - in process] (Source: Herpes)
Source: Herpes - November 21, 2018 Category: Infectious Diseases Authors: Diebold S, Overbeck M Tags: Emerg Med Clin North Am Source Type: research

Noninvasive and Local Delivery of Adenoviral-Mediated Herpes Simplex Virus Thymidine Kinase to Treat Glioma Through Focused Ultrasound-Induced Blood-Brain Barrier Opening in Rats.
In conclusion, our study provided a new strategy to efficiently and locally deliver recombinant adenoviral vector-mediated HSV-TK gene into the brain to treat glioma. PMID: 30305211 [PubMed - in process] (Source: Herpes)
Source: Herpes - October 12, 2018 Category: Infectious Diseases Authors: Pan M, Zhang Y, Deng Z, Yan F, Hong G Tags: J Biomed Nanotechnol Source Type: research

When a Seemingly Harmless Prescription Turns into Toxicity.
We present a case of a 71-year-old male who presented with altered mental status in the setting of recent herpes zoster eruption. His condition was attributed to valacyclovir neurotoxicity, and initiation of appropriate supportive therapy was met with complete resolution of symptoms and normalization of cognitive function. PMID: 30305816 [PubMed] (Source: Herpes)
Source: Herpes - October 12, 2018 Category: Infectious Diseases Authors: Azmaiparashvili Z, Lo KB, Habib N, Hsieh A Tags: Case Rep Med Source Type: research

Potential Transmission of Herpes Simplex Virus Via Vaginal Seeding.
PMID: 30308602 [PubMed - in process] (Source: Herpes)
Source: Herpes - October 12, 2018 Category: Infectious Diseases Authors: Huynh J, Palasanthiran P, McMullan B Tags: Pediatr Infect Dis J Source Type: research

Prevalence and anatomical sites of human papillomavirus, Epstein-Barr virus and herpes simplex virus infections in men who have sex with men, Khon Kaen, Thailand.
CONCLUSION: These results indicate that asymptomatic MSM in Northeast Thailand form a potential reservoir for transmission of STDs, and in particular for these viruses. PMID: 30305039 [PubMed - in process] (Source: Herpes)
Source: Herpes - October 11, 2018 Category: Infectious Diseases Authors: Chuerduangphui J, Proyrungroj K, Pientong C, Hinkan S, Budkaew J, Pimson C, Chumworathayi B, Hanond P, Ekalaksananan T Tags: BMC Infect Dis Source Type: research

The structural basis for cancer drug interactions with the catalytic and allosteric sites of SAMHD1.
In this study, we used biochemical, structural, and cellular methods to examine the interactions of various cancer drugs with SAMHD1. We found that both the catalytic and the allosteric sites of SAMHD1 are sensitive to sugar modifications of the nucleotide analogs, with the allosteric site being significantly more restrictive. We crystallized cladribine-TP, clofarabine-TP, fludarabine-TP, vidarabine-TP, cytarabine-TP, and gemcitabine-TP in the catalytic pocket of SAMHD1. We found that all of these drugs are substrates of SAMHD1 and that the efficacy of most of these drugs is affected by SAMHD1 activity. Of the nucleotide a...
Source: Herpes - October 10, 2018 Category: Infectious Diseases Authors: Knecht KM, Buzovetsky O, Schneider C, Thomas D, Srikanth V, Kaderali L, Tofoleanu F, Reiss K, Ferreirós N, Geisslinger G, Batista VS, Ji X, Cinatl J, Keppler OT, Xiong Y Tags: Proc Natl Acad Sci U S A Source Type: research

Commentary: Multiscale Analysis of Independent Alzheimer's Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks by Human Herpesvirus.
PMID: 30294260 [PubMed] (Source: Herpes)
Source: Herpes - October 9, 2018 Category: Infectious Diseases Authors: Sun XW, Liu CM, Teng ZQ Tags: Front Mol Neurosci Source Type: research

Herpes Zoster in Tofacitinib: Risk is Further Increased with Glucocorticoids but not Methotrexate.
CONCLUSION: In tofacitinib users, HZ occurred at a rate of approximately 4% per year and was further doubled with GC exposure. Concomitant MTX did not confer additional risk. Zoster vaccination may decrease risk. This article is protected by copyright. All rights reserved. PMID: 30295428 [PubMed - as supplied by publisher] (Source: Herpes)
Source: Herpes - October 8, 2018 Category: Infectious Diseases Authors: Curtis JR, Xie F, Yang S, Bernatsky S, Chen L, Yun H, Winthrop K Tags: Arthritis Care Res (Hoboken) Source Type: research

Infections of the esophagus: an update on risk factors, diagnosis, and management.
Abstract Infectious esophagitis is a leading cause of esophagitis worldwide. While esophageal infections have traditionally been associated with immunocompromised patients, these disorders are becoming increasingly recognized in immunocompetent individuals. The three most common etiologies of infectious esophagitis are Candida, herpes simplex virus, and cytomegalovirus. Human papilloma virus infection can also involve the esophagus in the form of ulcerative lesions and papillomas. Less common etiologies include various other fungal, bacterial, and viral organisms. This review provides a comprehensive update on ris...
Source: Herpes - October 8, 2018 Category: Infectious Diseases Authors: Hoversten P, Kamboj AK, Katzka DA Tags: Dis Esophagus Source Type: research

Lignin-carbohydrate complexes: properties, applications, analyses, and methods of extraction: a review.
Abstract The complexity of lignin and hemicellulose segmentation has been known since the middle of the ninetieth century. Studies confirmed that all lignin units in coniferous species and 47-66% of lignin moieties in deciduous species are bound to hemicelluloses or cellulose molecules in lignin-carbohydrate complexes (LCC). Different types and proportions of lignin and polysaccharides present in biomass lead to the formation of LCC with a great variety of compositions and structures. The nature and amount of LCC linkages and lignin substructures affect the efficiency of pulping, hydrolysis, and digestibility of b...
Source: Herpes - October 6, 2018 Category: Infectious Diseases Authors: Tarasov D, Leitch M, Fatehi P Tags: Biotechnol Biofuels Source Type: research

A Case Report on Acquired Tufted Angioma with Severe Pain after Healed Herpes Zoster.
PMID: 30246733 [PubMed - in process] (Source: Herpes)
Source: Herpes - September 25, 2018 Category: Infectious Diseases Authors: Cai YT, Xu H, Guo Y, Guo NN, Li YM Tags: Chin Med J (Engl) Source Type: research

ACOG Committee Opinion No. 754 Summary: The Utility of and Indications for Routine Pelvic Examination.
Authors: Abstract The pelvic examination has long been considered a fundamental component of the well-woman visit, and many women and gynecologic care providers view this visit as an opportunity to discuss sexual and reproductive health issues. Traditionally, a pelvic examination is performed for asymptomatic women as a screening tool for gynecologic cancer, infection, and asymptomatic pelvic inflammatory disease; some obstetrician-gynecologists and patients consider it important in detecting subclinical disease, despite evidence to the contrary. Given changes in screening recommendations and the ability to scree...
Source: Herpes - September 25, 2018 Category: Infectious Diseases Tags: Obstet Gynecol Source Type: research

ACOG Committee Opinion No. 754: The Utility of and Indications for Routine Pelvic Examination.
Authors: Abstract The pelvic examination has long been considered a fundamental component of the well-woman visit, and many women and gynecologic care providers view this visit as an opportunity to discuss sexual and reproductive health issues. Traditionally, a pelvic examination is performed for asymptomatic women as a screening tool for gynecologic cancer, infection, and asymptomatic pelvic inflammatory disease; some obstetrician-gynecologists and patients consider it important in detecting subclinical disease, despite evidence to the contrary. Given changes in screening recommendations and the ability to scree...
Source: Herpes - September 25, 2018 Category: Infectious Diseases Tags: Obstet Gynecol Source Type: research

Pharmacy Operationalization of the Intralesional Oncolytic Immunotherapy Talimogene Laherparepvec.
Conclusion: These insights may further inform the development of policies or procedures to incorporate talimogene laherparepvec into clinical settings and improve patient outcomes. PMID: 30210146 [PubMed] (Source: Herpes)
Source: Herpes - September 15, 2018 Category: Infectious Diseases Authors: McBride A, Valgus J, Parsad S, Sommermann EM, Nunan R Tags: Hosp Pharm Source Type: research