A putative design for the electromagnetic activation of split proteins for molecular and cellular manipulation
Front Bioeng Biotechnol. 2024 Mar 28;12:1355915. doi: 10.3389/fbioe.2024.1355915. eCollection 2024.ABSTRACTThe ability to manipulate cellular function using an external stimulus is a powerful strategy for studying complex biological phenomena. One approach to modulate the function of the cellular environment is split proteins. In this method, a biologically active protein or an enzyme is fragmented so that it reassembles only upon a specific stimulus. Although many tools are available to induce these systems, nature has provided other mechanisms to expand the split protein toolbox. Here, we show a novel method for reconsti...
Source: Herpes - April 12, 2024 Category: Infectious Diseases Authors: Connor J Grady E Alejandro Castellanos Franco Jory Schossau Ryan C Ashbaugh Galit Pelled Assaf A Gilad Source Type: research

Temporary Spinal Cord Stimulation for Herpes Zoster With Myelitis: A Case Series
Conclusions: Temporary SCS alleviated pain in cases of shingles with myelitis refractory to interventional therapy. Even in cases with myelitis, tSCS for ZAP remains an effective way to prevent PHN.PMID:38606211 | PMC:PMC11006553 | DOI:10.7759/cureus.55979 (Source: Herpes)
Source: Herpes - April 12, 2024 Category: Infectious Diseases Authors: Reon Kobayashi Asae Taketomi Eiko Hara Hitoshi Mera Katsunori Oe Source Type: research

Neonatal Herpes Reporting in the United States: Review of Current Policies by State
J Pediatric Infect Dis Soc. 2024 Apr 12:piae031. doi: 10.1093/jpids/piae031. Online ahead of print.NO ABSTRACTPMID:38606511 | DOI:10.1093/jpids/piae031 (Source: Herpes)
Source: Herpes - April 12, 2024 Category: Infectious Diseases Authors: Natalie Saremi Katherine A Lewis Jeffrey D Klausner Source Type: research

Satellite Glial Cells in Human Disease
Cells. 2024 Mar 23;13(7):566. doi: 10.3390/cells13070566.ABSTRACTSatellite glial cells (SGCs) are the main type of glial cells in sensory ganglia. Animal studies have shown that these cells play essential roles in both normal and disease states. In a large number of pain models, SGCs were activated and contributed to the pain behavior. Much less is known about SGCs in humans, but there is emerging recognition that SGCs in humans are altered in a variety of clinical states. The available data show that human SGCs share some essential features with SGCs in rodents, but many differences do exist. SGCs in DRG from patients suf...
Source: Herpes - April 12, 2024 Category: Infectious Diseases Authors: Menachem Hanani Source Type: research

Determination of HLA class II risk alleles and prediction of self/non-self-epitopes contributing Hashimoto's thyroiditis in a group of Iranian patients
This study aimed to determine the HLA-II risk alleles for developing Hashimoto's thyroiditis (HT) in order to analyze the molecular homology between candidate pathogen-derived epitopes and potentially self-antigens (thyroid peroxidase, TPO) based on the presence of HLA risk alleles. HLA-DRB1/-DQB1 genotyping was performed in 100 HT patients and 330 ethnically matched healthy controls to determine the predisposing/protective alleles for HT disease. Then, in silico analysis was conducted to examine the sequence homology between epitopes derived from autoantigens and four potentially relevant pathogens and their binding capac...
Source: Herpes - April 12, 2024 Category: Infectious Diseases Authors: Ata Shirizadeh Shiva Borzouei Zahra Razavi Amir Taherkhani Javad Faradmal Ghasem Solgi Source Type: research

Improving polymerase chain reaction diagnostic rates for herpes simplex keratitis: results of a pilot study
CONCLUSION: Our results suggest that, with proper swabbing technique, PCR may be more sensitive than previously reported.PMID:38601900 | PMC:PMC11001569 | DOI:10.5693/djo.01.2024.01.002 (Source: Herpes)
Source: Herpes - April 11, 2024 Category: Infectious Diseases Authors: Alice L Milligan Jeremy J Hoffman Yan Ning Neo Su-Yin Koay Source Type: research

Emerging drugs for the treatment of herpetic keratitis
Expert Opin Emerg Drugs. 2024 Apr 11:1-14. doi: 10.1080/14728214.2024.2339899. Online ahead of print.ABSTRACTINTRODUCTION: Herpes simplex keratitis stands as a prominent factor contributing to infectious blindness among developed nations. On a global scale, over 60% of the population tests positive for herpes simplex virus type-1 (HSV-1). Despite these statistics, there is currently no vaccine available for the virus. Moreover, the conventional nucleoside drugs prescribed to patients are proving ineffective in addressing issues related to drug resistance, recurrence, latency, and the escalating risk of vision loss. Hence, ...
Source: Herpes - April 11, 2024 Category: Infectious Diseases Authors: Divya Kapoor Pankaj Sharma Deepak Shukla Source Type: research

Updated Public Health Impact and Cost Effectiveness of Recombinant Zoster Vaccine in Canadian Adults Aged 50 Years and Older
CONCLUSIONS: RZV is expected to remain a cost-effective option for Canadian adults aged ≥50 years when using longer-term RZV efficacy and waning estimates, although the estimated public health impact was smaller than in the previous analysis (due to lower coverage/completion estimates).PMID:38605257 | DOI:10.1007/s41669-024-00483-w (Source: Herpes)
Source: Herpes - April 11, 2024 Category: Infectious Diseases Authors: Sydney George Justin Carrico Katherine A Hicks Dessi Loukov Cheryl Ng Jessica Regan Nikolaos Giannelos Source Type: research

Improving polymerase chain reaction diagnostic rates for herpes simplex keratitis: results of a pilot study
CONCLUSION: Our results suggest that, with proper swabbing technique, PCR may be more sensitive than previously reported.PMID:38601900 | PMC:PMC11001569 | DOI:10.5693/djo.01.2024.01.002 (Source: Herpes)
Source: Herpes - April 11, 2024 Category: Infectious Diseases Authors: Alice L Milligan Jeremy J Hoffman Yan Ning Neo Su-Yin Koay Source Type: research

Left mandibular osteonecrosis following herpes zoster of the third branch of left trigeminal nerve: A case report
This article presented a case of herpes zoster on the third branch of the left trigeminal nerve complicated with left mandibular osteonecrosis. We reported the case of a 64-year-old man with sudden pain in the left half of the tongue 1 month ago, and then herpes on the left facial skin appeared following with acute pain.The local hospital diagnosed it as herpes zoster and treated it with external medication. A few days later, he developed gum pain in the left mandibular posterior tooth area. He was admitted to Peking University School and Hospital of Stomatology one week ago with loose and dislodged left posterior tooth ac...
Source: Herpes - April 10, 2024 Category: Infectious Diseases Authors: Ying Zhou Ning Zhao Hongyuan Huang Qingxiang Li Chuanbin Guo Yuxing Guo Source Type: research

Ozone: An Adjunct in Dental Treatment
J Pharm Bioallied Sci. 2024 Feb;16(Suppl 1):S2-S4. doi: 10.4103/jpbs.jpbs_427_23. Epub 2023 Nov 7.ABSTRACTOzone is utilized in dentistry as ozonated oils, ozonated water, and gaseous ozone. The application of ozone in all specialties of dentistry has been demonstrated to be biocompatible. It has been demonstrated to encourage the remineralization of recently carious teeth, and it is utilized in dental caries and intracanal irrigants in endodontic treatment. Herpes virus infection, avascular osteonecrosis of the jaw, and alveolitis have all been treated with it. It can be applied as a supplement in the surgical and ongoing ...
Source: Herpes - April 10, 2024 Category: Infectious Diseases Authors: Poulami Goswami Kanchan Sharma Niladri Maiti Sweta Yadav Vartika Verma Rahul Puthenkandathil Source Type: research

Left dural carotid cavernous fistula mimicking an inflammatory process: A case report
Radiol Case Rep. 2024 Apr 5;19(6):2558-2560. doi: 10.1016/j.radcr.2024.03.021. eCollection 2024 Jun.ABSTRACTA female in her 70s presented with altered mental status, left eye pain, ophthalmalgia, and diplopia following a fall. Brain MRI demonstrated contrast-enhancing left peri-insular T2 hyperintense changes that was read as possible herpes simplex encephalitis by neuroradiology. Cerebral angiogram revealed a Barrow Type D left sided carotid cavernous fistula. The patient was subsequently treated with endovascular transvenous coil embolization of the left cavernous sinus resulting in complete occlusion of the fistula. The...
Source: Herpes - April 10, 2024 Category: Infectious Diseases Authors: Annika K Oie Amanda A Herrmann Michael H Rosenbloom Source Type: research

Oncolytic herpes simplex viruses designed for targeted treatment of EGFR-bearing tumors
Mol Ther Oncol. 2024 Jan 10;32(1):200761. doi: 10.1016/j.omton.2024.200761. eCollection 2024 Mar 21.ABSTRACTOncolytic herpes simplex viruses (oHSVs) have emerged as leading cancer therapeutic agents. Effective oHSV virotherapy may ultimately require both intratumoral and systemic vector administration to target the primary tumor and distant metastases. An attractive approach to enhancing oHSV tumor specificity is engineering the virus envelope glycoproteins for selective recognition of and infection via tumor-specific cell surface proteins. We previously demonstrated that oHSVs could be retargeted to EGFR-expressing cells ...
Source: Herpes - April 10, 2024 Category: Infectious Diseases Authors: Selene Ingusci Bonnie L Hall Justus B Cohen Joseph C Glorioso Source Type: research

TheraVision: Engineering platform technology for the development of oncolytic viruses based on herpes simplex virus type 1
Mol Ther Oncol. 2024 Feb 28;32(1):200784. doi: 10.1016/j.omton.2024.200784. eCollection 2024 Mar 21.ABSTRACTViruses are able to efficiently penetrate cells, multiply, and eventually kill infected cells, release tumor antigens, and activate the immune system. Therefore, viruses are highly attractive novel agents for cancer therapy. Clinical trials with first generations of oncolytic viruses (OVs) are very promising but show significant need for optimization. The aim of TheraVision was to establish a broadly applicable engineering platform technology for combinatorial oncolytic virus and immunotherapy. Through genetic engine...
Source: Herpes - April 10, 2024 Category: Infectious Diseases Authors: Christina Funk Nadja Uhlig Zsolt Ruzsics Florentin Baur Matthias Peindl Sarah Nietzer Karina Epting Gabriele Vacun Gudrun Dandekar Catherine Botteron Christian Werno Thomas Grunwald Susanne M Bailer Source Type: research

Development of a novel, high-efficacy oncolytic herpes simplex virus type 1 platform equipped with two distinct retargeting modalities
Mol Ther Oncol. 2024 Feb 20;32(1):200778. doi: 10.1016/j.omton.2024.200778. eCollection 2024 Mar 21.ABSTRACTTo retarget oncolytic herpes simplex virus (oHSV) to cancer-specific antigens, we designed a novel, double-retargeted oHSV platform that uses single-chain antibodies (scFvs) incorporated into both glycoprotein H and a bispecific adapter expressed from the viral genome to mediate infection predominantly via tumor-associated antigens. Successful retargeting was achieved using a nectin-1-detargeted HSV that remains capable of interacting with herpesvirus entry mediator (HVEM), the second canonical HSV entry receptor, an...
Source: Herpes - April 10, 2024 Category: Infectious Diseases Authors: Hyun-Yoo Joo Hyunjung Baek Chun-Seob Ahn Eun-Ran Park Youngju Lee Sujung Lee Mihee Han Bora Kim Yong-Hoon Jang Heechung Kwon Source Type: research