Severe Herpes Simplex Encephalitis: an Unusual Presentation of IPEX
J Clin Immunol. 2024 Apr 16;44(4):100. doi: 10.1007/s10875-024-01702-z.NO ABSTRACTPMID:38625673 | DOI:10.1007/s10875-024-01702-z (Source: Herpes)
Source: Herpes - April 16, 2024 Category: Infectious Diseases Authors: Linda Rossini Claudia Maria Bonardi Silvia Bresolin Eva Trevisson Antonio Marzollo Source Type: research
Herpes simplex keratitis: A brief clinical overview
World J Virol. 2024 Mar 25;13(1):89934. doi: 10.5501/wjv.v13.i1.89934.ABSTRACTThe aim of our minireview is to provide a brief overview of the diagnosis, clinical aspects, treatment options, management, and current literature available regarding herpes simplex keratitis (HSK). This type of corneal viral infection is caused by the herpes simplex virus (HSV), which can affect several tissues, including the cornea. One significant aspect of HSK is its potential to cause recurrent episodes of inflammation and damage to the cornea. After the initial infection, the HSV can establish a latent infection in the trigeminal ganglion, ...
Source: Herpes - April 15, 2024 Category: Infectious Diseases Authors: Mutali Musa Ehimare Enaholo Gladness Aluyi-Osa George Nnamdi Atuanya Leopoldo Spadea Carlo Salati Marco Zeppieri Source Type: research
Multiple ocular manifestations in a patient diagnosed with herpes zoster ophthalmicus: case report
Conclusions: Final visual acuity for the left eye remained 1 despite numerous manifestations of the disease. Abbreviations: VZV = Varicella-zoster virus, BCVA = best-corrected visual acuity, OU = both eyes, OD = right eye, OS = left eye, IOP = intraocular pressure, NCT = non-contact tonometer, ZVX = Zostavax vaccine.PMID:38617727 | PMC:PMC11007559 | DOI:10.22336/rjo.2024.16 (Source: Herpes)
Source: Herpes - April 15, 2024 Category: Infectious Diseases Authors: David-Ionu ț Beuran Mioara-Laura Macovei Ioana Ruxandra Boca Source Type: research
Kaposi's Sarcoma with Primary Lymph Node Involvement in a Retroviral Infected (RVI) Patient
Int Med Case Rep J. 2024 Apr 8;17:311-319. doi: 10.2147/IMCRJ.S458320. eCollection 2024.ABSTRACTOne kind of angioproliferative disorder is Kaposi's sarcoma (KS). Growth of spindle-shaped cells, edema, inflammation, and neoangiogenesis are its defining features. Because it lacks the typical indicators of malignancy, it is classified as an intermediate neoplasm. People who are immunocompromised, receiving organ transplants, or receiving antiretroviral therapy are linked to KS. Although lymph node involvement by KS is extremely uncommon, when it does occur, it usually manifests as either the epidemic form in (Human Immuno-def...
Source: Herpes - April 15, 2024 Category: Infectious Diseases Authors: Bizunesh Dires Fenta Alazar Berhe Aregawi Teketel Tadesse Geremew Berhanu Kelemework Fenta Source Type: research
Investigating the Effects of HMGB1 Overexpression on Colorectal Cancer Cell Migration via Oncolytic Herpes simplex Virus Type 1 (oHSV-1)
CONCLUSION: Our findings emphasize the complex regulation of CRC cell migration, and provides valuable insights into potential molecular mechanisms and pathways. These findings have implications for further research into cancer progression and the development of therapeutic strategies.PMID:38618508 | PMC:PMC11007377 | DOI:10.18502/ajmb.v16i2.14863 (Source: Herpes)
Source: Herpes - April 15, 2024 Category: Infectious Diseases Authors: Sara Shayan Arash Arashkia Golnaz Bahramali Kayhan Azadmanesh Source Type: research
In Patients With Inflammatory Bowel Disease, Racial Disparities Exist in Burden of Vaccine-preventable Disease Hospitalizations and Outcomes
CONCLUSIONS: Significant racial disparities in VPD hospitalization and in-hospital morbidity were found among adults with IBD in the United States. With the increasing prevalence of IBD in non-white populations, targeted efforts are needed to improve health equity.PMID:38619208 | DOI:10.1097/MCG.0000000000002005 (Source: Herpes)
Source: Herpes - April 15, 2024 Category: Infectious Diseases Authors: Christian Karime Miguel Salazar Cecily N Black Freddy Caldera Philip N Okafor Muhammad B Hammami Jana G Hashash Francis A Farraye Source Type: research
Combination of ganciclovir and trifluridine prevents drug-resistance emergence in HSV-1
Antimicrob Agents Chemother. 2024 Apr 15:e0011024. doi: 10.1128/aac.00110-24. Online ahead of print.ABSTRACTOcular herpes simplex virus 1 (HSV-1) infections can lead to visual impairment. Long-term acyclovir (ACV) prophylaxis reduces the frequency of recurrences but is associated with drug resistance. Novel therapies are needed to treat drug-resistant HSV-1 infections. Here, we describe the effects of trifluridine (TFT) in combination with ACV or ganciclovir (GCV) on HSV-1 replication and drug-resistance emergence. Wild-type HSV-1 was grown under increasing doses of one antiviral (ACV, GCV, or TFT) or combinations thereof ...
Source: Herpes - April 15, 2024 Category: Infectious Diseases Authors: Hanna Helena Schalkwijk Neesha Rajesh Shewakramani Kalyan Das Graciela Andrei Robert Snoeck Source Type: research
Progression of herpesvirus infection remodels mitochondrial organization and metabolism
PLoS Pathog. 2024 Apr 15;20(4):e1011829. doi: 10.1371/journal.ppat.1011829. Online ahead of print.ABSTRACTViruses target mitochondria to promote their replication, and infection-induced stress during the progression of infection leads to the regulation of antiviral defenses and mitochondrial metabolism which are opposed by counteracting viral factors. The precise structural and functional changes that underlie how mitochondria react to the infection remain largely unclear. Here we show extensive transcriptional remodeling of protein-encoding host genes involved in the respiratory chain, apoptosis, and structural organizati...
Source: Herpes - April 15, 2024 Category: Infectious Diseases Authors: Simon Leclerc Alka Gupta Visa Ruokolainen Jian-Hua Chen Kari Kunnas Axel A Ekman Henri Niskanen Ilya Belevich Helena Vihinen Paula Turkki Ana J Perez-Berna Sergey Kapishnikov Elina M äntylä Maria Harkiolaki Eric Dufour Vesa Hyt önen Eva Pereiro Tony Mc Source Type: research
CNS Aspergillosis and Cryptococcosis with Cytomegalovirus Pneumonia in a Patient with Chronic Lymphocytic Leukemia Treated with Acalabrutinib
We describe a 68-year-old male who developed multiple bacterial, fungal and viral infections while on treatment with acalabrutinib. To our knowledge, this is the first reported case of concomitant CNS infections with Cryptococcus neoformans and Aspergillus fumigatus, along with cytomegalovirus (CMV) and herpes simplex virus type 1 (HSV-1) pneumonia while on acalabrutinib. This case adds to the scarce literature of fungal and bacterial infections associated with acalabrutinib, raising the suspicion that infection risk is a medication class effect for BTKis.PMID:38621678 | DOI:10.1177/08971900241247660 (Source: Herpes)
Source: Herpes - April 15, 2024 Category: Infectious Diseases Authors: Taylor Fallin Erica Thacker Syeda Sahra Emily A Siegrist Bryan P White Katherine Summers Dena Shibib Joseph Sassine Source Type: research
Management of Oral Manifestations of Herpes Simplex Virus, Varicella Zoster Virus, and Human Papillomavirus
Compend Contin Educ Dent. 2024 Apr;45(4):192-197; quiz 198.ABSTRACTHuman herpes virus is a family of DNA viruses that includes herpes simplex virus (HSV) and varicella zoster virus (VZV). HSV-1 and HSV-2 are fairly common and result in oral and genital lesions. Recurrent infections of herpes include lesions on the lips resulting in pain and possibly societal stigma, making adequate treatment of these conditions crucial. VZV is the cause of chicken pox and shingles. Acyclovir and other nucleoside analogues have been the gold standard of treatment for HSV and VZV, but newer, more effective treatments are being developed, whi...
Source: Herpes - April 15, 2024 Category: Infectious Diseases Authors: Lauren Elkada Aviv Ouanounou Source Type: research
Efficacy of tocilizumab in patients with moderate-to-severe corticosteroid-resistant thyroid eye disease: a prospective study
CONCLUSION: TCZ can treat active moderate-to-severe TED, showing high drug compliance and reasonable response to inflammation and extraocular motility abnormality.PMID:38622479 | DOI:10.1007/s10792-024-03117-6 (Source: Herpes)
Source: Herpes - April 15, 2024 Category: Infectious Diseases Authors: Chaeyeon Lee Ji Woong Park Yoon-Duck Kim Kyung In Woo Source Type: research
Non-Thermal Plasma Reduces HSV-1 Infection of and Replication in HaCaT Keratinocytes In Vitro
Int J Mol Sci. 2024 Mar 29;25(7):3839. doi: 10.3390/ijms25073839.ABSTRACTHerpes simplex virus type 1 (HSV-1) is a lifelong pathogen characterized by asymptomatic latent infection in the trigeminal ganglia (TG), with periodic outbreaks of cold sores caused by virus reactivation in the TG and subsequent replication in the oral mucosa. While antiviral therapies can provide relief from cold sores, they are unable to eliminate HSV-1. We provide experimental results that highlight non-thermal plasma (NTP) as a new alternative therapy for HSV-1 infection that would resolve cold sores faster and reduce the establishment of latent ...
Source: Herpes - April 13, 2024 Category: Infectious Diseases Authors: Julia Sutter Jascha Brettschneider Brian Wigdahl Peter J Bruggeman Fred C Krebs Vandana Miller Source Type: research
Efficacy and safety of telitacicept in patients with lupus nephritis: a single-center, real-world retrospective study
CONCLUSIONS: Telitacicept treatment reduced disease severity in patients with LN. The initial clinical trial provided supportive evidence for the effectiveness and safety of Telitacicept as a viable treatment option for LN, allowing a reduction in the daily glucocorticoid intake while maintaining a good safety profile, and improving hypocomplementation in LN management.PMID:38613741 | DOI:10.1007/s10157-024-02501-x (Source: Herpes)
Source: Herpes - April 13, 2024 Category: Infectious Diseases Authors: Xiaolu Huang Fuan Lin Hongpu Chen Source Type: research
Immunogenicity and safety of an ORF7-deficient skin-attenuated and neuro-attenuated live vaccine for varicella: a randomised, double-blind, controlled, phase 2a trial
This study was registered on Chinese Clinical Trial Registry, ChiCTR2000034434.FINDINGS: On Aug 18-21, 2020, 842 eligible volunteers were enrolled and randomly assigned treatment. After three participants withdrew, 839 received a low dose (n=211), middle dose (n=210), or high dose (n=210) of v7D vaccine, or the vOka vaccine (n=208). In the per-protocol set for humoral immune response analysis, the anti-varicella zoster virus IgG antibody response was highest at day 90. At day 90, the seroconversion rates of the low-dose, medium-dose, and high-dose groups of v7D vaccine and the positive control vOka vaccine group were 100·...
Source: Herpes - April 13, 2024 Category: Infectious Diseases Authors: Hong-Xing Pan Ling-Xian Qiu Qi Liang Zhen Chen Ming-Lei Zhang Sheng Liu Guo-Hua Zhong Kong-Xin Zhu Meng-Jun Liao Jia-Lei Hu Jia-Xue Li Jin-Bo Xu Yong Fan Yue Huang Ying-Ying Su Shou-Jie Huang Wei Wang Jin-Le Han Ji-Zong Jia Hua Zhu Tong Cheng Xiang-Zhong Source Type: research
Behavioral toxicity and neurotoxic mechanisms of PLA-PBAT biodegradable microplastics in zebrafish
This study searched to investigate the acute and sub-chronic toxicity of polylactic acid (PLA) and polybutyleneadipate-co-terephthalate (PLA-PBAT) bio-microplastics on 3-month-old zebrafish to elucidate their potential toxic mechanisms. Acute toxicity assessments revealed 96 h-LC50 value of 12.69 mg/L for PLA-PBAT. Sub-chronic exposure of over 21 days revealed deviations in critical behavioral patterns and physiological indicators. In treated groups, weight gain and specific growth rates were significantly lower than those obtained for the control group, such that high doses induced significant reductions in total organ co...
Source: Herpes - April 13, 2024 Category: Infectious Diseases Authors: Deyong Zhang Xiaolu Xu Yin Lu Liang Guo Source Type: research
