Impact of Palliative Gastrectomy in Patients with Incurable Gastric Cancer
This study aimed to evaluate the impact of palliative gastrectomy (PG) on overall survival in gastric cancer patients. Materials and Methods: One hundred forty-eight gastric cancer patients who underwent PG or a nonresection (NR) procedure between January 2011 and 2017 were retrospectively reviewed to select and analyze clinicopathological factors that affected prognosis. Results: Fifty-five patients underwent primary tumor resection with palliative intent, and 93 underwent NR procedures owing to the presence of metastatic or unresectable disease. The PG group was younger and more female dominant. In the PG group, R1 and R...
Source: Medicina (Kaunas) - March 3, 2021 Category: Universities & Medical Training Authors: Ji Yeon Park Byunghyuk Yu Ki Bum Park Oh Kyoung Kwon Seung Soo Lee Ho Young Chung Source Type: research

Outcome Reporting Bias in COVID-19 mRNA Vaccine Clinical Trials
Medicina (Kaunas). 2021 Feb 26;57(3):199. doi: 10.3390/medicina57030199.ABSTRACTRelative risk reduction and absolute risk reduction measures in the evaluation of clinical trial data are poorly understood by health professionals and the public. The absence of reported absolute risk reduction in COVID-19 vaccine clinical trials can lead to outcome reporting bias that affects the interpretation of vaccine efficacy. The present article uses clinical epidemiologic tools to critically appraise reports of efficacy in Pfzier/BioNTech and Moderna COVID-19 mRNA vaccine clinical trials. Based on data reported by the manufacturer for ...
Source: Medicina (Kaunas) - March 3, 2021 Category: Universities & Medical Training Authors: Ronald B Brown Source Type: research

Our Evolving Understanding of ME/CFS
Medicina (Kaunas). 2021 Feb 26;57(3):200. doi: 10.3390/medicina57030200.ABSTRACTThe potential benefits of the scientific insights gleaned from years of treating ME/CFS for the emerging symptoms of COVID-19, and in particular Longhaul- or Longhauler-COVID-19 are discussed in this opinion article. Longhaul COVID-19 is the current name being given to the long-term sequelae (symptoms lasting beyond 6 weeks) of SARS-CoV-2 infection. Multiple case definitions for ME/CFS exist, but post-exertional malaise (PEM) is currently emerging as the 'hallmark' symptom. The inability to identify a unique trigger of ME/CFS, as well as the in...
Source: Medicina (Kaunas) - March 3, 2021 Category: Universities & Medical Training Authors: Kenneth J Friedman Modra Murovska Derek F H Pheby Pawe ł Zalewski Source Type: research

'De Novo' Brain AVMs-Hypotheses for Development and a Systematic Review of Reported Cases
Conclusions: Increasing evidence suggests that some of the AVMs discovered develop some time after birth. We are still a long way from finally elucidating their true nature, though there is reason to believe that they can also appear after birth. Thus, we reason that the de novo AVMs are the result of a 'second hit' of a variable type, such as a previous intracranial hemorrhage or vascular pathology. The congenital or acquired characteristic of AVMs may have a tremendous impact on prognosis, risk of hemorrhage, and short and long-term management.PMID:33652628 | DOI:10.3390/medicina57030201 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - March 3, 2021 Category: Universities & Medical Training Authors: Ioan Alexandru Florian Lehel Beni Vlad Moisoiu Teodora Larisa Timis Ioan Stefan Florian Adrian Bala șa Ioana Berindan-Neagoe Source Type: research

A Typical Case Presentation with Spontaneous Visual Recovery in Patient Diagnosed with Leber Hereditary Optic Neuropathy due to Rare Point Mutation in < em > MT-ND4 < /em > Gene ( < em > m.11253T & gt;C < /em > ) and Literature Review
Medicina (Kaunas). 2021 Feb 26;57(3):202. doi: 10.3390/medicina57030202.ABSTRACTLeber hereditary optic neuropathy (LHON) is one of the most common inherited mitochondrial optic neuropathies, caused by mitochondrial DNA (mtDNA) mutations. Three most common mutations, namely m.11778G>A, m.14484T>G and m.3460G>A, account for the majority of LHON cases. These mutations lead to mitochondrial respiratory chain complex I damage. Typically, LHON presents at the 15-35 years of age with male predominance. LHON is associated with severe, subacute, painless bilateral vision loss and account for one of the most common causes o...
Source: Medicina (Kaunas) - March 3, 2021 Category: Universities & Medical Training Authors: Rasa Liutkeviciene Agne Sidaraite Lina Kuliaviene Brigita Glebauskiene Neringa Jurkute Lina Aluzaite-Baranauskiene Arvydas Gelzinis Reda Zemaitiene Source Type: research

Does Surgical Margin Width Remain a Challenge for Triple-Negative Breast Cancer? A Retrospective Analysis
Conclusions: Our study supports a safe "no ink on tumor" approach for TNBC patients treated with BCS.PMID:33652670 | DOI:10.3390/medicina57030203 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - March 3, 2021 Category: Universities & Medical Training Authors: Eduard-Alexandru Bonci Ștefan Țîțu Alexandru Marius Petru șan Claudiu Hossu Vlad Alexandru G âta Morvarid Talaeian Ghomi Paul Milan Kubelac Teodora Irina Bonci Andra Piciu Maria Cosnarovici Liviu H îțu Alexandra Timea Kirsch-Mangu Diana Cristina P Source Type: research

Comparison of One-Year Functional Outcomes and Quality of Life between Posterior Pelvic Ring Fixation and Combined Anterior-Posterior Pelvic Ring Fixation after Lateral Compression (B2 Type) Pelvic Fracture
Conclusions: No differences were found in quality of life and functional outcomes between isolated posterior pelvic ring fixation and combined anterior-posterior fixation for the treatment of B2 type pelvic fractures.PMID:33652683 | DOI:10.3390/medicina57030204 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - March 3, 2021 Category: Universities & Medical Training Authors: Giedrius Petryla Valentinas Uvarovas Rokas Bobina Jaunius Kurtinaitis Roma Puronait ė Giedrius Kvederas Igoris Šatkauskas Source Type: research

Catheter Ablation of Life-Threatening Ventricular Arrhythmias in Athletes
Medicina (Kaunas). 2021 Feb 26;57(3):205. doi: 10.3390/medicina57030205.ABSTRACTA recent surveillance analysis indicates that cardiac arrest/death occurs in ≈1:50,000 professional or semi-professional athletes, and the most common cause is attributable to life-threatening ventricular arrhythmias (VAs). It is critically important to diagnose any inherited/acquired cardiac disease, including coronary artery disease, since it frequently represents the arrhythmogenic substrate in a substantial part of the athletes presenting with major VAs. New insights indicate that athletes develop a specific electro-anatomical remodel...
Source: Medicina (Kaunas) - March 3, 2021 Category: Universities & Medical Training Authors: Nicola Tarantino Domenico G Della Rocca Nicole S De Leon De La Cruz Eric D Manheimer Michele Magnocavallo Carlo Lavalle Carola Gianni Sanghamitra Mohanty Chintan Trivedi Amin Al-Ahmad Rodney P Horton Mohamed Bassiouny J David Burkhardt G Joseph Gallinghou Source Type: research

First-Time Acute Lateral Patellar Dislocation in Children and Adolescents: What About Unaffected Knee Patellofemoral Joint Anatomic Abnormalities?
Medicina (Kaunas). 2021 Feb 26;57(3):206. doi: 10.3390/medicina57030206.ABSTRACTBackground and Objectives: Acute lateral patellar dislocation (LPD) is the most common acute knee disorder in children and adolescents, and may lead to functional disability. The purpose of this study was to identify key differences and correlations of the patellofemoral joint (PFJ) morphology between intact and contralateral injured knees in a first-time traumatic LPD population aged under 18 years. Materials and Methods: The data were gathered prospectively from a cohort of 58 patients (35 girls and 23 boys). The prevalence and combined preva...
Source: Medicina (Kaunas) - March 3, 2021 Category: Universities & Medical Training Authors: Rasa Simonaityt ė Saulius Rutkauskas Emilis Čekanauskas Liutauras Labanauskas Vidmantas Barauskas Source Type: research

A 30-Month Complete Urinary Obstruction Resulting from Trapped and Incarcerated Uterus: A Case Report
Medicina (Kaunas). 2021 Feb 26;57(3):207. doi: 10.3390/medicina57030207.ABSTRACTUterine incarceration is rare, but it can caus e serious complications, in which the uterus is trapped in the pelvic cavity behind the sacral promontory. Fibroid uterus can cause urinary frequency and retention, which can result from compression of the urinary bladder with an enlarged fibroid uterus and the compression of the bladder neck or urethra, respectively. To our knowledge, there is no report on prolonged complete urinary obstruction because of an incarcerated uterus in nonpregnant women to date. A 51-year-old woman was referred for ute...
Source: Medicina (Kaunas) - March 3, 2021 Category: Universities & Medical Training Authors: Gina Nam Sa Ra Lee Sung Hoon Kim Hee Dong Chae Source Type: research

Perceptions of European ME/CFS Experts Concerning Knowledge and Understanding of ME/CFS among Primary Care Physicians in Europe: A Report from the European ME/CFS Research Network (EUROMENE)
Conclusion: The results of this survey are consistent with the existing scientific literature. ME/CFS experts report that lack of knowledge and understanding of ME/CFS among GPs is a major cause of missed and delayed diagnoses, which renders problematic attempts to determine the incidence and prevalence of the disease, and to measure its economic impact. It also contributes to the burden of disease through mismanagement in its early stages.PMID:33652747 | DOI:10.3390/medicina57030208 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - March 3, 2021 Category: Universities & Medical Training Authors: John Cullinan Derek F H Pheby Diana Araja Uldis Berkis Elenka Brenna Jean-Dominique de Korwin Lara Gitto Dyfrig A Hughes Rachael M Hunter Dominic Trepel Xia Wang-Steverding Source Type: research

Relationship between Trace Element in Tumor and Prognosis in Lung Cancer Patients
Conclusions: This study suggests that the prognosis is good in lung cancer cases with high intratumoral concentrations of Co and Cr. The dynamics of trace elements in body and in tumor tissue have not been well established, and we consider that more research is necessary in the future.PMID:33652756 | DOI:10.3390/medicina57030209 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - March 3, 2021 Category: Universities & Medical Training Authors: Hirotaka Saikawa Hiromi Nagashima Katsuya Cho Ryosuke Chiba Koichiro Sera Wataru Shigeeda Makoto Tomoyasu Hiroyuki Deguchi Fumiaki Takahashi Hajime Saito Tamotsu Sugai Makoto Maemondo Source Type: research

Assessment of Liver Stiffness Regression and Hepatocellular Carcinoma Risk in Chronic Hepatitis C Patients after Treatment with Direct-Acting Antiviral Drugs
Conclusions: Liver stiffness decrease was significant as early as 12 weeks after the end of treatment. Patients with diabetes and advanced liver disease are at higher risk of developing non-regressive fibrosis and hepatocellular carcinoma even after successful treatment.PMID:33652777 | DOI:10.3390/medicina57030210 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - March 3, 2021 Category: Universities & Medical Training Authors: Martynas Ridziauskas Birut ė Zablockienė Ligita Jan čorienė Art ūras Samuilis Rolandas Zablockis Au šrinė Jackevičiūtė Source Type: research

The Prevalence of Ureaplasma Urealyticum and Mycoplasma Hominis Infections in Infertile Patients in the Northeast Region of Romania
Conclusions: The most susceptible age groups in each case were women that were between twenty and forty years old. It can be concluded that four antibiotics can be safely used for treating UU, MH, or dual infections whose efficiency was over 95%.PMID:33652790 | DOI:10.3390/medicina57030211 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - March 3, 2021 Category: Universities & Medical Training Authors: Bogdan Doroftei Ovidiu-Dumitru Ilie Theodora Armeanu Emil Anton Ioana Scripcariu Radu Maftei Source Type: research

Novel Targeted Therapies for Advanced Cholangiocarcinoma
Medicina (Kaunas). 2021 Feb 26;57(3):212. doi: 10.3390/medicina57030212.ABSTRACTCholangiocarcinoma (CCA) includes a group of rare and aggressive hepatobiliary malignancies, including extrahepatic cholangiocarcinoma (eCCA) and intrahepatic cholangiocarcinoma (iCCA), with the former further subdivided into distal (dCCA) and perihilar cholangiocarcinoma (pCCA) [...].PMID:33652960 | DOI:10.3390/medicina57030212 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - March 3, 2021 Category: Universities & Medical Training Authors: Alessandro Rizzo Giovanni Brandi Source Type: research

Impact of Palliative Gastrectomy in Patients with Incurable Gastric Cancer
This study aimed to evaluate the impact of palliative gastrectomy (PG) on overall survival in gastric cancer patients. Materials and Methods: One hundred forty-eight gastric cancer patients who underwent PG or a nonresection (NR) procedure between January 2011 and 2017 were retrospectively reviewed to select and analyze clinicopathological factors that affected prognosis. Results: Fifty-five patients underwent primary tumor resection with palliative intent, and 93 underwent NR procedures owing to the presence of metastatic or unresectable disease. The PG group was younger and more female dominant. In the PG group, R1 and R...
Source: Medicina (Kaunas) - March 3, 2021 Category: Universities & Medical Training Authors: Ji Yeon Park Byunghyuk Yu Ki Bum Park Oh Kyoung Kwon Seung Soo Lee Ho Young Chung Source Type: research

Outcome Reporting Bias in COVID-19 mRNA Vaccine Clinical Trials
Medicina (Kaunas). 2021 Feb 26;57(3):199. doi: 10.3390/medicina57030199.ABSTRACTRelative risk reduction and absolute risk reduction measures in the evaluation of clinical trial data are poorly understood by health professionals and the public. The absence of reported absolute risk reduction in COVID-19 vaccine clinical trials can lead to outcome reporting bias that affects the interpretation of vaccine efficacy. The present article uses clinical epidemiologic tools to critically appraise reports of efficacy in Pfzier/BioNTech and Moderna COVID-19 mRNA vaccine clinical trials. Based on data reported by the manufacturer for ...
Source: Medicina (Kaunas) - March 3, 2021 Category: Universities & Medical Training Authors: Ronald B Brown Source Type: research

Our Evolving Understanding of ME/CFS
Medicina (Kaunas). 2021 Feb 26;57(3):200. doi: 10.3390/medicina57030200.ABSTRACTThe potential benefits of the scientific insights gleaned from years of treating ME/CFS for the emerging symptoms of COVID-19, and in particular Longhaul- or Longhauler-COVID-19 are discussed in this opinion article. Longhaul COVID-19 is the current name being given to the long-term sequelae (symptoms lasting beyond 6 weeks) of SARS-CoV-2 infection. Multiple case definitions for ME/CFS exist, but post-exertional malaise (PEM) is currently emerging as the 'hallmark' symptom. The inability to identify a unique trigger of ME/CFS, as well as the in...
Source: Medicina (Kaunas) - March 3, 2021 Category: Universities & Medical Training Authors: Kenneth J Friedman Modra Murovska Derek F H Pheby Pawe ł Zalewski Source Type: research

'De Novo' Brain AVMs-Hypotheses for Development and a Systematic Review of Reported Cases
Conclusions: Increasing evidence suggests that some of the AVMs discovered develop some time after birth. We are still a long way from finally elucidating their true nature, though there is reason to believe that they can also appear after birth. Thus, we reason that the de novo AVMs are the result of a 'second hit' of a variable type, such as a previous intracranial hemorrhage or vascular pathology. The congenital or acquired characteristic of AVMs may have a tremendous impact on prognosis, risk of hemorrhage, and short and long-term management.PMID:33652628 | DOI:10.3390/medicina57030201 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - March 3, 2021 Category: Universities & Medical Training Authors: Ioan Alexandru Florian Lehel Beni Vlad Moisoiu Teodora Larisa Timis Ioan Stefan Florian Adrian Bala șa Ioana Berindan-Neagoe Source Type: research

A Typical Case Presentation with Spontaneous Visual Recovery in Patient Diagnosed with Leber Hereditary Optic Neuropathy due to Rare Point Mutation in < em > MT-ND4 < /em > Gene ( < em > m.11253T & gt;C < /em > ) and Literature Review
Medicina (Kaunas). 2021 Feb 26;57(3):202. doi: 10.3390/medicina57030202.ABSTRACTLeber hereditary optic neuropathy (LHON) is one of the most common inherited mitochondrial optic neuropathies, caused by mitochondrial DNA (mtDNA) mutations. Three most common mutations, namely m.11778G>A, m.14484T>G and m.3460G>A, account for the majority of LHON cases. These mutations lead to mitochondrial respiratory chain complex I damage. Typically, LHON presents at the 15-35 years of age with male predominance. LHON is associated with severe, subacute, painless bilateral vision loss and account for one of the most common causes o...
Source: Medicina (Kaunas) - March 3, 2021 Category: Universities & Medical Training Authors: Rasa Liutkeviciene Agne Sidaraite Lina Kuliaviene Brigita Glebauskiene Neringa Jurkute Lina Aluzaite-Baranauskiene Arvydas Gelzinis Reda Zemaitiene Source Type: research

Does Surgical Margin Width Remain a Challenge for Triple-Negative Breast Cancer? A Retrospective Analysis
Conclusions: Our study supports a safe "no ink on tumor" approach for TNBC patients treated with BCS.PMID:33652670 | DOI:10.3390/medicina57030203 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - March 3, 2021 Category: Universities & Medical Training Authors: Eduard-Alexandru Bonci Ștefan Țîțu Alexandru Marius Petru șan Claudiu Hossu Vlad Alexandru G âta Morvarid Talaeian Ghomi Paul Milan Kubelac Teodora Irina Bonci Andra Piciu Maria Cosnarovici Liviu H îțu Alexandra Timea Kirsch-Mangu Diana Cristina P Source Type: research

Comparison of One-Year Functional Outcomes and Quality of Life between Posterior Pelvic Ring Fixation and Combined Anterior-Posterior Pelvic Ring Fixation after Lateral Compression (B2 Type) Pelvic Fracture
Conclusions: No differences were found in quality of life and functional outcomes between isolated posterior pelvic ring fixation and combined anterior-posterior fixation for the treatment of B2 type pelvic fractures.PMID:33652683 | DOI:10.3390/medicina57030204 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - March 3, 2021 Category: Universities & Medical Training Authors: Giedrius Petryla Valentinas Uvarovas Rokas Bobina Jaunius Kurtinaitis Roma Puronait ė Giedrius Kvederas Igoris Šatkauskas Source Type: research

Catheter Ablation of Life-Threatening Ventricular Arrhythmias in Athletes
Medicina (Kaunas). 2021 Feb 26;57(3):205. doi: 10.3390/medicina57030205.ABSTRACTA recent surveillance analysis indicates that cardiac arrest/death occurs in ≈1:50,000 professional or semi-professional athletes, and the most common cause is attributable to life-threatening ventricular arrhythmias (VAs). It is critically important to diagnose any inherited/acquired cardiac disease, including coronary artery disease, since it frequently represents the arrhythmogenic substrate in a substantial part of the athletes presenting with major VAs. New insights indicate that athletes develop a specific electro-anatomical remodel...
Source: Medicina (Kaunas) - March 3, 2021 Category: Universities & Medical Training Authors: Nicola Tarantino Domenico G Della Rocca Nicole S De Leon De La Cruz Eric D Manheimer Michele Magnocavallo Carlo Lavalle Carola Gianni Sanghamitra Mohanty Chintan Trivedi Amin Al-Ahmad Rodney P Horton Mohamed Bassiouny J David Burkhardt G Joseph Gallinghou Source Type: research

First-Time Acute Lateral Patellar Dislocation in Children and Adolescents: What About Unaffected Knee Patellofemoral Joint Anatomic Abnormalities?
Medicina (Kaunas). 2021 Feb 26;57(3):206. doi: 10.3390/medicina57030206.ABSTRACTBackground and Objectives: Acute lateral patellar dislocation (LPD) is the most common acute knee disorder in children and adolescents, and may lead to functional disability. The purpose of this study was to identify key differences and correlations of the patellofemoral joint (PFJ) morphology between intact and contralateral injured knees in a first-time traumatic LPD population aged under 18 years. Materials and Methods: The data were gathered prospectively from a cohort of 58 patients (35 girls and 23 boys). The prevalence and combined preva...
Source: Medicina (Kaunas) - March 3, 2021 Category: Universities & Medical Training Authors: Rasa Simonaityt ė Saulius Rutkauskas Emilis Čekanauskas Liutauras Labanauskas Vidmantas Barauskas Source Type: research

A 30-Month Complete Urinary Obstruction Resulting from Trapped and Incarcerated Uterus: A Case Report
Medicina (Kaunas). 2021 Feb 26;57(3):207. doi: 10.3390/medicina57030207.ABSTRACTUterine incarceration is rare, but it can caus e serious complications, in which the uterus is trapped in the pelvic cavity behind the sacral promontory. Fibroid uterus can cause urinary frequency and retention, which can result from compression of the urinary bladder with an enlarged fibroid uterus and the compression of the bladder neck or urethra, respectively. To our knowledge, there is no report on prolonged complete urinary obstruction because of an incarcerated uterus in nonpregnant women to date. A 51-year-old woman was referred for ute...
Source: Medicina (Kaunas) - March 3, 2021 Category: Universities & Medical Training Authors: Gina Nam Sa Ra Lee Sung Hoon Kim Hee Dong Chae Source Type: research

Perceptions of European ME/CFS Experts Concerning Knowledge and Understanding of ME/CFS among Primary Care Physicians in Europe: A Report from the European ME/CFS Research Network (EUROMENE)
Conclusion: The results of this survey are consistent with the existing scientific literature. ME/CFS experts report that lack of knowledge and understanding of ME/CFS among GPs is a major cause of missed and delayed diagnoses, which renders problematic attempts to determine the incidence and prevalence of the disease, and to measure its economic impact. It also contributes to the burden of disease through mismanagement in its early stages.PMID:33652747 | DOI:10.3390/medicina57030208 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - March 3, 2021 Category: Universities & Medical Training Authors: John Cullinan Derek F H Pheby Diana Araja Uldis Berkis Elenka Brenna Jean-Dominique de Korwin Lara Gitto Dyfrig A Hughes Rachael M Hunter Dominic Trepel Xia Wang-Steverding Source Type: research

Relationship between Trace Element in Tumor and Prognosis in Lung Cancer Patients
Conclusions: This study suggests that the prognosis is good in lung cancer cases with high intratumoral concentrations of Co and Cr. The dynamics of trace elements in body and in tumor tissue have not been well established, and we consider that more research is necessary in the future.PMID:33652756 | DOI:10.3390/medicina57030209 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - March 3, 2021 Category: Universities & Medical Training Authors: Hirotaka Saikawa Hiromi Nagashima Katsuya Cho Ryosuke Chiba Koichiro Sera Wataru Shigeeda Makoto Tomoyasu Hiroyuki Deguchi Fumiaki Takahashi Hajime Saito Tamotsu Sugai Makoto Maemondo Source Type: research

Assessment of Liver Stiffness Regression and Hepatocellular Carcinoma Risk in Chronic Hepatitis C Patients after Treatment with Direct-Acting Antiviral Drugs
Conclusions: Liver stiffness decrease was significant as early as 12 weeks after the end of treatment. Patients with diabetes and advanced liver disease are at higher risk of developing non-regressive fibrosis and hepatocellular carcinoma even after successful treatment.PMID:33652777 | DOI:10.3390/medicina57030210 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - March 3, 2021 Category: Universities & Medical Training Authors: Martynas Ridziauskas Birut ė Zablockienė Ligita Jan čorienė Art ūras Samuilis Rolandas Zablockis Au šrinė Jackevičiūtė Source Type: research

The Prevalence of Ureaplasma Urealyticum and Mycoplasma Hominis Infections in Infertile Patients in the Northeast Region of Romania
Conclusions: The most susceptible age groups in each case were women that were between twenty and forty years old. It can be concluded that four antibiotics can be safely used for treating UU, MH, or dual infections whose efficiency was over 95%.PMID:33652790 | DOI:10.3390/medicina57030211 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - March 3, 2021 Category: Universities & Medical Training Authors: Bogdan Doroftei Ovidiu-Dumitru Ilie Theodora Armeanu Emil Anton Ioana Scripcariu Radu Maftei Source Type: research

Novel Targeted Therapies for Advanced Cholangiocarcinoma
Medicina (Kaunas). 2021 Feb 26;57(3):212. doi: 10.3390/medicina57030212.ABSTRACTCholangiocarcinoma (CCA) includes a group of rare and aggressive hepatobiliary malignancies, including extrahepatic cholangiocarcinoma (eCCA) and intrahepatic cholangiocarcinoma (iCCA), with the former further subdivided into distal (dCCA) and perihilar cholangiocarcinoma (pCCA) [...].PMID:33652960 | DOI:10.3390/medicina57030212 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - March 3, 2021 Category: Universities & Medical Training Authors: Alessandro Rizzo Giovanni Brandi Source Type: research

Impact of Palliative Gastrectomy in Patients with Incurable Gastric Cancer
This study aimed to evaluate the impact of palliative gastrectomy (PG) on overall survival in gastric cancer patients. Materials and Methods: One hundred forty-eight gastric cancer patients who underwent PG or a nonresection (NR) procedure between January 2011 and 2017 were retrospectively reviewed to select and analyze clinicopathological factors that affected prognosis. Results: Fifty-five patients underwent primary tumor resection with palliative intent, and 93 underwent NR procedures owing to the presence of metastatic or unresectable disease. The PG group was younger and more female dominant. In the PG group, R1 and R...
Source: Medicina (Kaunas) - March 3, 2021 Category: Universities & Medical Training Authors: Ji Yeon Park Byunghyuk Yu Ki Bum Park Oh Kyoung Kwon Seung Soo Lee Ho Young Chung Source Type: research

Outcome Reporting Bias in COVID-19 mRNA Vaccine Clinical Trials
Medicina (Kaunas). 2021 Feb 26;57(3):199. doi: 10.3390/medicina57030199.ABSTRACTRelative risk reduction and absolute risk reduction measures in the evaluation of clinical trial data are poorly understood by health professionals and the public. The absence of reported absolute risk reduction in COVID-19 vaccine clinical trials can lead to outcome reporting bias that affects the interpretation of vaccine efficacy. The present article uses clinical epidemiologic tools to critically appraise reports of efficacy in Pfzier/BioNTech and Moderna COVID-19 mRNA vaccine clinical trials. Based on data reported by the manufacturer for ...
Source: Medicina (Kaunas) - March 3, 2021 Category: Universities & Medical Training Authors: Ronald B Brown Source Type: research

Our Evolving Understanding of ME/CFS
Medicina (Kaunas). 2021 Feb 26;57(3):200. doi: 10.3390/medicina57030200.ABSTRACTThe potential benefits of the scientific insights gleaned from years of treating ME/CFS for the emerging symptoms of COVID-19, and in particular Longhaul- or Longhauler-COVID-19 are discussed in this opinion article. Longhaul COVID-19 is the current name being given to the long-term sequelae (symptoms lasting beyond 6 weeks) of SARS-CoV-2 infection. Multiple case definitions for ME/CFS exist, but post-exertional malaise (PEM) is currently emerging as the 'hallmark' symptom. The inability to identify a unique trigger of ME/CFS, as well as the in...
Source: Medicina (Kaunas) - March 3, 2021 Category: Universities & Medical Training Authors: Kenneth J Friedman Modra Murovska Derek F H Pheby Pawe ł Zalewski Source Type: research

'De Novo' Brain AVMs-Hypotheses for Development and a Systematic Review of Reported Cases
Conclusions: Increasing evidence suggests that some of the AVMs discovered develop some time after birth. We are still a long way from finally elucidating their true nature, though there is reason to believe that they can also appear after birth. Thus, we reason that the de novo AVMs are the result of a 'second hit' of a variable type, such as a previous intracranial hemorrhage or vascular pathology. The congenital or acquired characteristic of AVMs may have a tremendous impact on prognosis, risk of hemorrhage, and short and long-term management.PMID:33652628 | DOI:10.3390/medicina57030201 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - March 3, 2021 Category: Universities & Medical Training Authors: Ioan Alexandru Florian Lehel Beni Vlad Moisoiu Teodora Larisa Timis Ioan Stefan Florian Adrian Bala șa Ioana Berindan-Neagoe Source Type: research

A Typical Case Presentation with Spontaneous Visual Recovery in Patient Diagnosed with Leber Hereditary Optic Neuropathy due to Rare Point Mutation in < em > MT-ND4 < /em > Gene ( < em > m.11253T & gt;C < /em > ) and Literature Review
Medicina (Kaunas). 2021 Feb 26;57(3):202. doi: 10.3390/medicina57030202.ABSTRACTLeber hereditary optic neuropathy (LHON) is one of the most common inherited mitochondrial optic neuropathies, caused by mitochondrial DNA (mtDNA) mutations. Three most common mutations, namely m.11778G>A, m.14484T>G and m.3460G>A, account for the majority of LHON cases. These mutations lead to mitochondrial respiratory chain complex I damage. Typically, LHON presents at the 15-35 years of age with male predominance. LHON is associated with severe, subacute, painless bilateral vision loss and account for one of the most common causes o...
Source: Medicina (Kaunas) - March 3, 2021 Category: Universities & Medical Training Authors: Rasa Liutkeviciene Agne Sidaraite Lina Kuliaviene Brigita Glebauskiene Neringa Jurkute Lina Aluzaite-Baranauskiene Arvydas Gelzinis Reda Zemaitiene Source Type: research

Does Surgical Margin Width Remain a Challenge for Triple-Negative Breast Cancer? A Retrospective Analysis
Conclusions: Our study supports a safe "no ink on tumor" approach for TNBC patients treated with BCS.PMID:33652670 | DOI:10.3390/medicina57030203 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - March 3, 2021 Category: Universities & Medical Training Authors: Eduard-Alexandru Bonci Ștefan Țîțu Alexandru Marius Petru șan Claudiu Hossu Vlad Alexandru G âta Morvarid Talaeian Ghomi Paul Milan Kubelac Teodora Irina Bonci Andra Piciu Maria Cosnarovici Liviu H îțu Alexandra Timea Kirsch-Mangu Diana Cristina P Source Type: research

Comparison of One-Year Functional Outcomes and Quality of Life between Posterior Pelvic Ring Fixation and Combined Anterior-Posterior Pelvic Ring Fixation after Lateral Compression (B2 Type) Pelvic Fracture
Conclusions: No differences were found in quality of life and functional outcomes between isolated posterior pelvic ring fixation and combined anterior-posterior fixation for the treatment of B2 type pelvic fractures.PMID:33652683 | DOI:10.3390/medicina57030204 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - March 3, 2021 Category: Universities & Medical Training Authors: Giedrius Petryla Valentinas Uvarovas Rokas Bobina Jaunius Kurtinaitis Roma Puronait ė Giedrius Kvederas Igoris Šatkauskas Source Type: research

Catheter Ablation of Life-Threatening Ventricular Arrhythmias in Athletes
Medicina (Kaunas). 2021 Feb 26;57(3):205. doi: 10.3390/medicina57030205.ABSTRACTA recent surveillance analysis indicates that cardiac arrest/death occurs in ≈1:50,000 professional or semi-professional athletes, and the most common cause is attributable to life-threatening ventricular arrhythmias (VAs). It is critically important to diagnose any inherited/acquired cardiac disease, including coronary artery disease, since it frequently represents the arrhythmogenic substrate in a substantial part of the athletes presenting with major VAs. New insights indicate that athletes develop a specific electro-anatomical remodel...
Source: Medicina (Kaunas) - March 3, 2021 Category: Universities & Medical Training Authors: Nicola Tarantino Domenico G Della Rocca Nicole S De Leon De La Cruz Eric D Manheimer Michele Magnocavallo Carlo Lavalle Carola Gianni Sanghamitra Mohanty Chintan Trivedi Amin Al-Ahmad Rodney P Horton Mohamed Bassiouny J David Burkhardt G Joseph Gallinghou Source Type: research

First-Time Acute Lateral Patellar Dislocation in Children and Adolescents: What About Unaffected Knee Patellofemoral Joint Anatomic Abnormalities?
Medicina (Kaunas). 2021 Feb 26;57(3):206. doi: 10.3390/medicina57030206.ABSTRACTBackground and Objectives: Acute lateral patellar dislocation (LPD) is the most common acute knee disorder in children and adolescents, and may lead to functional disability. The purpose of this study was to identify key differences and correlations of the patellofemoral joint (PFJ) morphology between intact and contralateral injured knees in a first-time traumatic LPD population aged under 18 years. Materials and Methods: The data were gathered prospectively from a cohort of 58 patients (35 girls and 23 boys). The prevalence and combined preva...
Source: Medicina (Kaunas) - March 3, 2021 Category: Universities & Medical Training Authors: Rasa Simonaityt ė Saulius Rutkauskas Emilis Čekanauskas Liutauras Labanauskas Vidmantas Barauskas Source Type: research

A 30-Month Complete Urinary Obstruction Resulting from Trapped and Incarcerated Uterus: A Case Report
Medicina (Kaunas). 2021 Feb 26;57(3):207. doi: 10.3390/medicina57030207.ABSTRACTUterine incarceration is rare, but it can caus e serious complications, in which the uterus is trapped in the pelvic cavity behind the sacral promontory. Fibroid uterus can cause urinary frequency and retention, which can result from compression of the urinary bladder with an enlarged fibroid uterus and the compression of the bladder neck or urethra, respectively. To our knowledge, there is no report on prolonged complete urinary obstruction because of an incarcerated uterus in nonpregnant women to date. A 51-year-old woman was referred for ute...
Source: Medicina (Kaunas) - March 3, 2021 Category: Universities & Medical Training Authors: Gina Nam Sa Ra Lee Sung Hoon Kim Hee Dong Chae Source Type: research

Perceptions of European ME/CFS Experts Concerning Knowledge and Understanding of ME/CFS among Primary Care Physicians in Europe: A Report from the European ME/CFS Research Network (EUROMENE)
Conclusion: The results of this survey are consistent with the existing scientific literature. ME/CFS experts report that lack of knowledge and understanding of ME/CFS among GPs is a major cause of missed and delayed diagnoses, which renders problematic attempts to determine the incidence and prevalence of the disease, and to measure its economic impact. It also contributes to the burden of disease through mismanagement in its early stages.PMID:33652747 | DOI:10.3390/medicina57030208 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - March 3, 2021 Category: Universities & Medical Training Authors: John Cullinan Derek F H Pheby Diana Araja Uldis Berkis Elenka Brenna Jean-Dominique de Korwin Lara Gitto Dyfrig A Hughes Rachael M Hunter Dominic Trepel Xia Wang-Steverding Source Type: research

Relationship between Trace Element in Tumor and Prognosis in Lung Cancer Patients
Conclusions: This study suggests that the prognosis is good in lung cancer cases with high intratumoral concentrations of Co and Cr. The dynamics of trace elements in body and in tumor tissue have not been well established, and we consider that more research is necessary in the future.PMID:33652756 | DOI:10.3390/medicina57030209 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - March 3, 2021 Category: Universities & Medical Training Authors: Hirotaka Saikawa Hiromi Nagashima Katsuya Cho Ryosuke Chiba Koichiro Sera Wataru Shigeeda Makoto Tomoyasu Hiroyuki Deguchi Fumiaki Takahashi Hajime Saito Tamotsu Sugai Makoto Maemondo Source Type: research

Assessment of Liver Stiffness Regression and Hepatocellular Carcinoma Risk in Chronic Hepatitis C Patients after Treatment with Direct-Acting Antiviral Drugs
Conclusions: Liver stiffness decrease was significant as early as 12 weeks after the end of treatment. Patients with diabetes and advanced liver disease are at higher risk of developing non-regressive fibrosis and hepatocellular carcinoma even after successful treatment.PMID:33652777 | DOI:10.3390/medicina57030210 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - March 3, 2021 Category: Universities & Medical Training Authors: Martynas Ridziauskas Birut ė Zablockienė Ligita Jan čorienė Art ūras Samuilis Rolandas Zablockis Au šrinė Jackevičiūtė Source Type: research

The Prevalence of Ureaplasma Urealyticum and Mycoplasma Hominis Infections in Infertile Patients in the Northeast Region of Romania
Conclusions: The most susceptible age groups in each case were women that were between twenty and forty years old. It can be concluded that four antibiotics can be safely used for treating UU, MH, or dual infections whose efficiency was over 95%.PMID:33652790 | DOI:10.3390/medicina57030211 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - March 3, 2021 Category: Universities & Medical Training Authors: Bogdan Doroftei Ovidiu-Dumitru Ilie Theodora Armeanu Emil Anton Ioana Scripcariu Radu Maftei Source Type: research

Novel Targeted Therapies for Advanced Cholangiocarcinoma
Medicina (Kaunas). 2021 Feb 26;57(3):212. doi: 10.3390/medicina57030212.ABSTRACTCholangiocarcinoma (CCA) includes a group of rare and aggressive hepatobiliary malignancies, including extrahepatic cholangiocarcinoma (eCCA) and intrahepatic cholangiocarcinoma (iCCA), with the former further subdivided into distal (dCCA) and perihilar cholangiocarcinoma (pCCA) [...].PMID:33652960 | DOI:10.3390/medicina57030212 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - March 3, 2021 Category: Universities & Medical Training Authors: Alessandro Rizzo Giovanni Brandi Source Type: research

Clinical Features and Outcome of Infective Endocarditis in a University Hospital in Romania
Conclusions: Staphylococcus aureus IE was associated with the presence of large vegetations, prosthetic valve endocarditis and intracardiac abscess. Coagulase negative Staphylococcus (CoNS) infection was associated with prosthetic valve dysfunction. Streptococcus gallolyticus etiology correlated with ischemic embolic stroke and the presence of large vegetations. Cardiovascular surgery was recommended in 67.4% of patients but was performed only on half of them. In hospital death occurred in 33.7% of patients and independent predictors of mortality were congestive heart failure and septic shock.PMID:33578787 | PMC:PMC7916483...
Source: Medicina (Kaunas) - February 13, 2021 Category: Universities & Medical Training Authors: Emilia Elena Babe ș Diana Anca Lucu ța Codru ța Diana Petcheși Andreea Atena Zaha Cristian Ilyes Alexandru Daniel Jurca Cosmin Mihai Vesa Dana Carmen Zaha Vlad Victor Babe ș Source Type: research

The Role of Exercise to Reduce the Impact of Diabetes in the Seminal Quality: A Systematic Review
Conclusions: Physical exercise could ameliorate diabetic pathological effects on sperm quality and related parameters that cause infertility or subfertility conditions. However, further homogeneous studies are needed to confirm these findings.PMID:33578871 | PMC:PMC7916555 | DOI:10.3390/medicina57020159 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - February 13, 2021 Category: Universities & Medical Training Authors: Ana Myriam Lav ín-Pérez Daniel Collado-Mateo Santos Villafaina Violeta Calle-Guisado Source Type: research

Serological Parameters and Vascular Investigation for a Better Assessment in DVT during Pregnancy-A Systematic Review
Medicina (Kaunas). 2021 Feb 10;57(2):160. doi: 10.3390/medicina57020160.ABSTRACTPregnancy and the postpartum period represent a condition characterized by a thrombotic predisposition. The majority of pregnant women do not face acute or severe thrombotic events. In general, mild inconveniences such as leg swelling or moderately painful thrombotic events (phlebitis) are encountered. However, when pregnancy is associated with inherited or acquired deficits that affect homeostasis, the risk of acute or even life-threatening events can increase significantly. The major consequence is the loss of the fetus or the venous thromboe...
Source: Medicina (Kaunas) - February 13, 2021 Category: Universities & Medical Training Authors: Catalina Filip Demetra Gabriela Socolov Elena Albu Cristiana Filip Roxana Serban Radu Florin Popa Source Type: research

Mutual Influence of Psoriasis and Sport
Medicina (Kaunas). 2021 Feb 10;57(2):161. doi: 10.3390/medicina57020161.ABSTRACTThe link between psoriasis and sport is a controversial issue. The topic has been poorly investigated, and nowadays there are many unsolved questions, dealing with the role of psoriasis in influencing the sporting habits of patients and, vice versa, the impact of sport activity on course, severity and extent of the disease, with particular regard to the indirect benefits on cardiovascular risk and metabolic syndrome. Moreover, the role of physical activity on patients' quality of life and the potential limitations on physical activity due to jo...
Source: Medicina (Kaunas) - February 13, 2021 Category: Universities & Medical Training Authors: Paolo Custurone Laura Macca Lucrezia Bertino Debora Di Mauro Fabio Trimarchi Mario Vaccaro Francesco Borgia Source Type: research

Clinical Features and Outcome of Infective Endocarditis in a University Hospital in Romania
Conclusions: Staphylococcus aureus IE was associated with the presence of large vegetations, prosthetic valve endocarditis and intracardiac abscess. Coagulase negative Staphylococcus (CoNS) infection was associated with prosthetic valve dysfunction. Streptococcus gallolyticus etiology correlated with ischemic embolic stroke and the presence of large vegetations. Cardiovascular surgery was recommended in 67.4% of patients but was performed only on half of them. In hospital death occurred in 33.7% of patients and independent predictors of mortality were congestive heart failure and septic shock.PMID:33578787 | PMC:PMC7916483...
Source: Medicina (Kaunas) - February 13, 2021 Category: Universities & Medical Training Authors: Emilia Elena Babe ș Diana Anca Lucu ța Codru ța Diana Petcheși Andreea Atena Zaha Cristian Ilyes Alexandru Daniel Jurca Cosmin Mihai Vesa Dana Carmen Zaha Vlad Victor Babe ș Source Type: research