Role of Key Micronutrients from Nutrigenetic and Nutrigenomic Perspectives in Cancer Prevention.
Abstract Regarding cancer as a genetic multi-factorial disease, a number of aspects need to be investigated and analyzed in terms of cancer's predisposition, development and prognosis. One of these multi-dimensional factors, which has gained increased attention in the oncological field due to its unelucidated role in risk assessment for cancer, is diet. Moreover, as studies advance, a clearer connection between diet and the molecular alteration of patients is becoming identifiable and quantifiable, thereby replacing the old general view associating specific phenotypical changes with the differential intake of nutr...
Source: Medicina (Kaunas) - June 18, 2019 Category: Universities & Medical Training Authors: Irimie AI, Braicu C, Pasca S, Magdo L, Gulei D, Cojocneanu R, Ciocan C, Olariu A, Coza O, Berindan-Neagoe I Tags: Medicina (Kaunas) Source Type: research

Pro-Resolving Lipid Mediators in the Pathophysiology of Asthma.
Abstract Asthma is one of the most important medical and social problems of our time due to the prevalence and the complexity of its treatment. Chronic inflammation that is characteristic of asthma is accompanied by bronchial obstruction, which involves various lipid mediators produced from n-6 and n-3 polyunsaturated fatty acids (PUFAs). The review is devoted to modern ideas about the PUFA metabolites-eicosanoids (leukotrienes, prostaglandins, thromboxanes) and specialized pro-resolving lipid mediators (SPMs) maresins, lipoxins, resolvins, protectins. The latest advances in clinical lipidomics for identifying and...
Source: Medicina (Kaunas) - June 18, 2019 Category: Universities & Medical Training Authors: Kytikova O, Novgorodtseva T, Denisenko Y, Antonyuk M, Gvozdenko T Tags: Medicina (Kaunas) Source Type: research

Resistance Trends and Epidemiology of Citrobacter-Enterobacter-Serratia in Urinary Tract Infections of Inpatients and Outpatients (RECESUTI): A 10-Year Survey.
Conclusions: Resistance developments of CES bacteria, coupled with their intrinsic non-susceptibility to several antibiotics, severely limits the number of therapeutic alternatives, especially for outpatients. PMID: 31216725 [PubMed - in process] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - June 18, 2019 Category: Universities & Medical Training Authors: Gajdács M, Urbán E Tags: Medicina (Kaunas) Source Type: research

Is Self-Reported Physical Fitness Useful for Estimating Fitness Levels in Children and Adolescents? A Reliability and Validity Study.
Conclusions: The Portuguese version of the IFIS is a reliable and valid method for measuring physical fitness in pediatric populations. PMID: 31216737 [PubMed - in process] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - June 18, 2019 Category: Universities & Medical Training Authors: De Moraes ACF, Vilanova-Campelo RC, Torres-Leal FL, Carvalho HB Tags: Medicina (Kaunas) Source Type: research

The Role of Hematological Parameters in Predicting Fuhrman Grade and Tumor Stage in Renal Cell Carcinoma Patients Undergoing Nephrectomy.
Conclusions: We determined that only RDW and NLR were markers predicting FG, while PCT had no prognostic value. On the other hand, all three of these values were associated with a limited to the kidney pathological T stage in patients who underwent nephrectomy due to renal masses and whose pathologies suggested RCC. PMID: 31216752 [PubMed - in process] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - June 18, 2019 Category: Universities & Medical Training Authors: Kisa E, Yucel C, Keskin MZ, Karabicak M, Yalcin MY, Cakmak O, Ilbey YO Tags: Medicina (Kaunas) Source Type: research

Effects of Boxing Matches on Metabolic, Hormonal, and Inflammatory Parameters in Male Elite Boxers.
Conclusion: Elevations in the level of energy fuels and metabolic hormones of the boxers could be taken as a reflection of high-energy turnover during combat performance. The increases in inflammatory and tissue damage indicators may possibly be an indication of traumatic injury. Understanding the biochemical changes that occur during boxing match could be valuable to optimize the performance improvement of the athletes. PMID: 31216765 [PubMed - in process] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - June 18, 2019 Category: Universities & Medical Training Authors: Kılıc Y, Cetin HN, Sumlu E, Pektas MB, Koca HB, Akar F Tags: Medicina (Kaunas) Source Type: research

Experimental Models of Glaucoma: A Powerful Translational Tool for the Future Development of New Therapies for Glaucoma in Humans-A Review of the Literature.
Conclusions: Knowing the exact characteristics of each glaucoma experimental model could help to diminish inconveniences related to the process of the translation of results into clinical application in humans. PMID: 31212881 [PubMed - in process] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - June 17, 2019 Category: Universities & Medical Training Authors: Evangelho K, Mastronardi CA, de-la-Torre A Tags: Medicina (Kaunas) Source Type: research

Assessment of Physical Fitness after Bariatric Surgery and Its Association with Protein Intake and Type of Cholecalciferol Supplementation.
Conclusion: We have found that serum 25 (OH) cholecalciferol and different cholecalciferol supplementation regimes do not have a significant effect on HS and SWRT before, three and 6 months after surgery. It seems that protein intake plays a more important role in maintaining adequate muscle strength. PMID: 31213023 [PubMed - in process] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - June 17, 2019 Category: Universities & Medical Training Authors: Smelt HJM, Pouwels S, Celik A, Gupta A, Smulders JF Tags: Medicina (Kaunas) Source Type: research

Qualitative Assessment of Vaccine Hesitancy in Romania.
Conclusions: One-third of the investigated population had expressed VH, and a further one-third of these had refused a vaccine for their child. Chicken Pox, Measles, Mumps, Rubella (MMR), and HPV vaccines generated the most hesitation. Negative information from the media was the most frequently evoked reason for VH. PMID: 31213037 [PubMed - in process] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - June 17, 2019 Category: Universities & Medical Training Authors: Miko D, Costache C, Colosi HA, Neculicioiu V, Colosi IA Tags: Medicina (Kaunas) Source Type: research

Identification of Risk Factors for Multiple Non-Melanoma Skin Cancers in Italian Kidney Transplant Recipients.
Conclusions: Our results confirm the role played by chronic cutaneous actinic damage in carcinogenesis on KTRs and highlight the significance of individualized periodic dermatological screening. PMID: 31208110 [PubMed - in process] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - June 16, 2019 Category: Universities & Medical Training Authors: Zavattaro E, Fava P, Veronese F, Cavaliere G, Ferrante D, Cantaluppi V, Ranghino A, Biancone L, Fierro MT, Savoia P Tags: Medicina (Kaunas) Source Type: research

Interventions to Increase the Rate of Influenza and Pneumococcal Vaccination in Patients with Chronic Obstructive Pulmonary Disease: A Scoping Review.
Conclusions: Further, adequately powered, high quality studies are needed. It is crucial for individual institutions to monitor their own vaccination rates to determine if there is scope for performance improvement. PMID: 31208087 [PubMed - in process] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - June 15, 2019 Category: Universities & Medical Training Authors: Trethewey SP, Patel N, Turner AM Tags: Medicina (Kaunas) Source Type: research

Factors Influencing the Quality of Life of Healthy Pregnant Women in North Jordan.
Conclusions: Parity factor and social support should be recognized in any health promotion intervention and during providing antenatal care. Further research is needed toassess the QOL during pregnancy. PMID: 31208100 [PubMed - in process] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - June 15, 2019 Category: Universities & Medical Training Authors: Alzboon G, Vural G Tags: Medicina (Kaunas) Source Type: research

An Investigation of Oxidative Stress and Thiol/Disulphide Homeostasis in Graves' Disease.
Abstract Background and objectives: The aim of this study was to research oxidative stress and thiol/disulphide homeostasis in Graves' patients. Materials and Methods: The study included 33 Graves' patients (research group) and 35 healthy subjects (control group). Serum oxidative stress and thiol/disulphide homeostasis (a new and automated spectrophotometric method developed by Erel and Neselioglu) parameters were studied and compared between the groups. Results: The native and total thiol levels and the native thiol/total thiol ratio were lower in patients with Graves' disease compared to the control group (p
Source: Medicina (Kaunas) - June 14, 2019 Category: Universities & Medical Training Authors: Agan V, Celik H, Eren MA, Agan FZ, Erel O, Neselioglu S, Koyuncu I, Gonel A Tags: Medicina (Kaunas) Source Type: research

Prevalence of Musculoskeletal Injuries, Pain, and Illnesses in Elite Female Basketball Players.
Conclusions: The main findings showed the importance of monitoring lower extremity injuries and pain to pay attention to the players, which are at risk. The occurrence of injuries and pain among female basketball players was high. The lower extremities are the most frequently injured body area in the Lithuanian Women's Basketball League. PMID: 31207961 [PubMed - in process] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - June 14, 2019 Category: Universities & Medical Training Authors: Garbenytė-Apolinskienė T, Salatkaitė S, Šiupšinskas L, Gudas R Tags: Medicina (Kaunas) Source Type: research

Tissue Oxygen Saturation Change on Upper Extremities After Ultrasound-Guided Infraclavicular Brachial Plexus Blockade; Prospective Observational Study.
ırat E Abstract Background and Objective: The aim of this study was to investigate whether tissue oxygen saturation (StO2) is a reliable and objective method for assessing the adequacy of infraclavicular block and to describe the time course of StO2 changes. Materials and Methods: In this prospective observational study, StO2 was measured in 40 patients planned for elective hand surgery under infraclavicular block. Noninvasive StO2 monitoring was used prior to ultrasound-guided infraclavicular brachial plexus block and during the first 30 min of the blockade. Sensory and motor blocks were evaluated every 5 min fo...
Source: Medicina (Kaunas) - June 14, 2019 Category: Universities & Medical Training Authors: Karahan MA, Binici O, Büyükfırat E Tags: Medicina (Kaunas) Source Type: research

Local and Systemic IL-7 Concentration in Gastrointestinal-Tract Cancers.
Conclusions: IL-7 protein is overexpressed in EC, GC, and CRC, but concentrations differ both in tumor and tumor-adjacent tissue with respect to tumor location. More advanced cancers have lower IL-7 concentrations in the immediate environment of the tumor. At the systemic level, IL-7 is elevated in CRC and EC, but not CC or GC. IL-7 dependence on the location of the primary tumor should be taken into account in future IL-7-based immunotherapies. Functional studies explaining a role of IL-7 in gastrointestinal cancers are needed. PMID: 31185636 [PubMed - in process] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - June 10, 2019 Category: Universities & Medical Training Authors: Bednarz-Misa I, Diakowska D, Krzystek-Korpacka M Tags: Medicina (Kaunas) Source Type: research

The Importance of the Mediastinal Triangle in Traumatic Lesions of the Aorta.
Conclusions: Patients with trauma due to traffic accidents or being run over presented three times more risk of aortic injury than from other causes. Those with an aortic lesion also had a higher frequency of cardiopericardial, airway, and esophageal lesions. PMID: 31185662 [PubMed - in process] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - June 10, 2019 Category: Universities & Medical Training Authors: Gulias-Soidan D, Fraga-Manteiga D, Mosquera-Rodriguez VX, Marini-Diaz M, Lopez-Bargiela P, González-Martín C, Balboa-Barreiro V Tags: Medicina (Kaunas) Source Type: research

Genetic Association of Angiotensin-Converting Enzyme (ACE) Gene I/D Polymorphism with Preterm Birth in Korean Women: Case-Control Study and Meta-Analysis.
Abstract BACKGROUND AND OBJECTIVES: The ACE gene encodes the angiotensin-converting enzyme (ACE), a component of the renin-angiotensin system. Increased ACE activity may cause abnormal regulation of placental circulation and angiogenesis, resulting in adverse pregnancy outcomes. Previous studies have reported that the insertion/deletion (I/D) polymorphism of the ACE gene is associated with the development of preterm birth (PTB). However, results of the association between ACE gene I/D and PTB are inconsistent in various populations. Therefore, we performed a case-control study and a meta-analysis to evaluate the a...
Source: Medicina (Kaunas) - June 10, 2019 Category: Universities & Medical Training Authors: Lee NR, Hwang IW, Kim HJ, Kang YD, Park JW, Jin HJ Tags: Medicina (Kaunas) Source Type: research

Treatment of Unstable Pediatric Tibial Shaft Fractures with Titanium Elastic Nails.
In this study, we evaluated radiological and functional outcomes in pediatric patients with tibial shaft fractures that underwent fixation with TENs. Materials and methods: A total of twenty tibial shaft fractures that were treated with TENs in our clinic between 2013 and 2017 were retrospectively reviewed. The mean age at injury was 8.9 ± 2.78 (range of 3-14) years. Seven (35%) out of 20 fractures were open fractures, of which one fracture was classified as Grade I and six fractures were classified as Grade II. In each patient, antegrade nailing was performed by inserting a TEN in the medial and another TEN in the ...
Source: Medicina (Kaunas) - June 10, 2019 Category: Universities & Medical Training Authors: Uludağ A, Tosun HB Tags: Medicina (Kaunas) Source Type: research

Bioavailability of Different Vitamin D Oral Supplements in Laboratory Animal Model.
Conclusions: The results of this study suggest that the oral vitamin D supplement vehicle has an impact on its bioavailability, thus it is important to take into account how much of the suppled vitamin D will be absorbed. To maximize the full exploit of supplement, the best delivery strategy should be employed. In our study, the microencapsulated form of vitamin D was the most bioavailable. PMID: 31185696 [PubMed - in process] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - June 10, 2019 Category: Universities & Medical Training Authors: Šimoliūnas E, Rinkūnaitė I, Bukelskienė Ž, Bukelskienė V Tags: Medicina (Kaunas) Source Type: research

Prediction of Chronic Lower Back Pain Using the Hierarchical Neural Network: Comparison with Logistic Regression-A Pilot Study.
Conclusions: On the basis of the ROC curve, the RMSE, and the -2 log likelihood, the performance of the HNN for the prediction probability of CLBP is equal to or higher than the LR. In the future, the HNN may be useful as an index to judge the risk of CLBP for individual patients. PMID: 31181815 [PubMed - in process] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - June 9, 2019 Category: Universities & Medical Training Authors: Owari Y, Miyatake N Tags: Medicina (Kaunas) Source Type: research

Cardiac Magnetic Resonance Imaging and Transthoracic Echocardiography: Investigation of Concordance between the Two Methods for Measurement of the Cardiac Chamber.
Conclusions: TTE and CMR indicated high concordance in chamber diameter measurements for which the CMR should be considered in patients for whom optimal evaluation with TTE could not be performed due to their limitations. PMID: 31181857 [PubMed - in process] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - June 9, 2019 Category: Universities & Medical Training Authors: Gürdoğan M, Ustabaşıoğlu FE, Kula O, Korkmaz S Tags: Medicina (Kaunas) Source Type: research

Evaluation of the Impact of Black Carbon on the Worsening of Allergic Respiratory Diseases in the Region of Western Serbia: A Time-Stratified Case-Crossover Study.
Conclusion: Exposure to BC in the Užice region increases the risk of ED visits for allergic rhinitis and asthma, particularly during the heating season. PMID: 31181862 [PubMed - in process] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - June 9, 2019 Category: Universities & Medical Training Authors: Tomić-Spirić V, Kovačević G, Marinković J, Janković J, Ćirković A, Milošević Đerić A, Relić N, Janković S Tags: Medicina (Kaunas) Source Type: research

Salivary and Serum Interferon-Gamma/Interleukin-4 Ratio in Oral Lichen Planus Patients: A Systematic Review and Meta-Analysis.
Conclusions: In conclusion, the results of meta-analysis demonstrated that serum and salivary IFN-γ/IL-4 ratio cannot play a major role in OLP development and severity. PMID: 31181785 [PubMed - in process] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - June 8, 2019 Category: Universities & Medical Training Authors: Mozaffari HR, Molavi M, Lopez-Jornet P, Sadeghi M, Safaei M, Imani MM, Sharifi R, Moradpoor H, Golshah A, Jamshidy L Tags: Medicina (Kaunas) Source Type: research

Female Volleyball Players Are More Prone to Cortisol Anticipatory Stress Response than Sedentary Women.
ska E Abstract Background and Objectives: Top-level sports performance places heavy physical and psychological demands on elite-level athletes, which can be a source of increased levels of stress. Therefore, high-level volleyball players may present altered cardiovascular and endocrinological stress response during stressful events. Although many previous studies have examined the response to stress on athletes, most of them regarded only males, while the impact of the female menstrual cycle has rarely been taken into account. We aimed to study psychophysiological response to anticipatory stressor through analysis...
Source: Medicina (Kaunas) - June 8, 2019 Category: Universities & Medical Training Authors: Dziembowska I, Wójcik M, Hołyńska-Iwan I, Litwic-Kaminska K, Słomka A, Żekanowska E Tags: Medicina (Kaunas) Source Type: research

Older Adults-Potential Users of Technologies.
Conclusions: Lithuanian older women in the study used computers, the internet, and cell phones equally with men. Increasing age was a strong negative predictor of technology use. A positive attitude to new technologies was a strong positive predictor of technology use. Most geriatric patients and community-dwelling older adults were ready to use technologies that permit ageing in place. PMID: 31181673 [PubMed - in process] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - June 7, 2019 Category: Universities & Medical Training Authors: Lesauskaitė V, Damulevičienė G, Knašienė J, Kazanavičius E, Liutkevičius A, Janavičiūtė A Tags: Medicina (Kaunas) Source Type: research

The Effect of an Innovative Biofeedback SKOL-AS ® Treatment on the Body Posture and Trunk Rotation in Children with Idiopathic Scoliosis-Preliminary Study.
Conclusions: The SKOL-AS® biofeedback method could teach good postural habits and teach patients the auto-correction of the spine. PMID: 31181685 [PubMed - in process] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - June 7, 2019 Category: Universities & Medical Training Authors: Kamelska-Sadowska AM, Protasiewicz-Fałdowska H, Zakrzewska L, Zaborowska-Sapeta K, Nowakowski JJ, Kowalski IM Tags: Medicina (Kaunas) Source Type: research

Drimia indica: A Plant Used in Traditional Medicine and Its Potential for Clinical Uses.
Abstract Drimia indica (Roxb.) Jessop (Asparagaceae) is a reputed Ayurvedic medicine for a number of therapeutic benefits, including for cardiac diseases, indigestion, asthma, dropsy, rheumatism, leprosy, and skin ailments. The present work aimed to critically and extensively review its traditional uses, phytochemistry, pharmacology, toxicology, and taxonomy together with the mechanisms of action of selected extracts of D. indica. A systematic literature survey from scientific databases such as PubMed, Scopus, and Web of Science as well as from some textbooks and classical texts was conducted. The plant, mainly it...
Source: Medicina (Kaunas) - June 7, 2019 Category: Universities & Medical Training Authors: Aswal S, Kumar A, Semwal RB, Chauhan A, Kumar A, Lehmann J, Semwal DK Tags: Medicina (Kaunas) Source Type: research

Ultrasonographic Evaluation of The Effects of Orthodontic or Functional Orthopaedic Treatment on Masseter Muscles: A Systematic Review and Meta-Analysis.
Conclusions: Although the meta-analysis revealed that US could be considered a less invasive and effective method to evaluate the masseter muscle thickness, single-blinded RCTs, are required to confirm US reliability in this field of application. This review was registered on PROSPERO with the following registration number: CRD42018068402. PMID: 31181706 [PubMed - in process] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - June 7, 2019 Category: Universities & Medical Training Authors: Patini R, Gallenzi P, Lione R, Cozza P, Cordaro M Tags: Medicina (Kaunas) Source Type: research

Heart Involvement in Inflammatory Rheumatic Diseases: A Systematic Literature Review.
Conclusions: Early detection, adequate management and therapy of specific cardiac involvement are essential in rheumatic disease. Electrocardiographic and echocardiographic evaluation should be performed as routine investigations in patients with inflammatory rheumatic diseases. PMID: 31174287 [PubMed - in process] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - June 6, 2019 Category: Universities & Medical Training Authors: Buleu F, Sirbu E, Caraba A, Dragan S Tags: Medicina (Kaunas) Source Type: research

Normative Data for Handgrip Strength in Saudi Older Adults Visiting Primary Health Care Centers.
Abstract Background and objective: Handgrip strength (HGS) plays a vital role as a predictor of adverse health outcomes. Several studies have established HGS norms by age, sex, hand, occupation, culture or disability in different countries and for children in Saudi Arabia. However, standardized values for Saudi older adults have not yet been reported. Therefore, the current study was aimed to establish normative data for HGS in Saudi older adults visiting primary health care centers (PHCCs). Material and Method: In this descriptive cross-sectional study, HGS in kilograms was measured using a hydraulic hand dynamom...
Source: Medicina (Kaunas) - June 6, 2019 Category: Universities & Medical Training Authors: Bindawas SM, Vennu V, Al-Orf SM, Alshammari SA, Al-Amoud MM, Calder PC, Al-Muammar MN, Alhamdan AA Tags: Medicina (Kaunas) Source Type: research

Effect of a Combined Stretching and Strength Training Program on Gait Function in Children with Cerebral Palsy, GMFCS Level I & II: A Randomized Controlled Trial.
Conclusion: A 16-week combined stretching and PRE program followed by a 16-week maintenance program did not improve gait function in ambulant children with CP. PMID: 31174397 [PubMed - in process] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - June 6, 2019 Category: Universities & Medical Training Authors: Fosdahl MA, Jahnsen R, Kvalheim K, Holm I Tags: Medicina (Kaunas) Source Type: research

The Influence of Different Cholecalciferol Supplementation Regimes on 25(OH) Cholecalciferol, Calcium and Parathyroid Hormone after Bariatric Surgery.
Abstract Background and objectives: Vitamin D is an essential vitamin that plays a key role in maintaining physiological calcium balance, and is also a pivotal element in the formation of bone structure. Vitamin D deficiency is associated with a wide array of clinical symptoms. Vitamin and mineral deficiencies are quite common prior to and after bariatric surgery, and therefore we have evaluated the effects of two different cholecalciferol supplementation regimes on serum calcium, 25(OH) cholecalciferol, and parathyroid hormone (PTH). Materials and Methods: In this retrospective matched cohort study, two different...
Source: Medicina (Kaunas) - June 6, 2019 Category: Universities & Medical Training Authors: Smelt HJM, Pouwels S, Smulders JF Tags: Medicina (Kaunas) Source Type: research

Knowledge and Attitude Among Lebanese Pregnant Women Toward Cord Blood Stem Cell Storage and Donation.
Conclusion: Respondents who had an existing knowledge about UCB stem cells banking in general were more likely to consider storing UCB in blood banks if affordable (45.9%). Therefore, it is necessary to inform pregnant women about stem cell banking so that they can make the appropriate decisions for themselves. PMID: 31167466 [PubMed - in process] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - June 4, 2019 Category: Universities & Medical Training Authors: Saleh FA Tags: Medicina (Kaunas) Source Type: research

Cerebrospinal Fluid Analysis in Multiple Sclerosis Diagnosis: An Update.
This article reviews the current knowledge on CSF biomarkers used in the diagnosis of MS, in particular on the validated assays and on the alternative biomarkers of intrathecal synthesis. PMID: 31167509 [PubMed - in process] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - June 4, 2019 Category: Universities & Medical Training Authors: Lo Sasso B, Agnello L, Bivona G, Bellia C, Ciaccio M Tags: Medicina (Kaunas) Source Type: research

Time from Symptom Onset to Diagnosis and Treatment among Haematological Malignancies: Influencing Factors and Associated Negative Outcomes.
Conclusion: Median overall diagnostic delay was nearly 5 months, indicating that there is room for improvement. The most important factors causing delays were living in big cities, anxiety and depression, self-medication, and more specialists seen before diagnosis. Diagnostic delay may have a negative influence on clinical outcomes for multiple myeloma patients. PMID: 31163661 [PubMed - in process] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - June 3, 2019 Category: Universities & Medical Training Authors: Dapkevičiūtė A, Šapoka V, Martynova E, Pečeliūnas V Tags: Medicina (Kaunas) Source Type: research

Morphological Stages of Mitochondrial Vacuolar Degeneration in Phenylephrine-Stressed Cardiac Myocytes and in Animal Models and Human Heart Failure.
Conclusion: Mitochondrial vacuolar degeneration is a prominent mitochondrial morphological feature seen in HF. Defining the progressive stages of mitochondrial vacuolar degeneration would serve as a measure to assess morphologically the severity of mitochondrial damage. PMID: 31163678 [PubMed - in process] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - June 3, 2019 Category: Universities & Medical Training Authors: Chaanine AH Tags: Medicina (Kaunas) Source Type: research

Quality of Life and Female Sexual Dysfunction in Croatian Women with Stress-, Urgency- and Mixed Urinary Incontinence: Results of a Cross-Sectional Study.
The objective of this study was to evaluate the differences in the occurrence of decreased quality of life and female sexual dysfunction in Croatian women with urinary incontinence, with regard to the duration and subtype of urinary incontinence. Materials and Methods: We conducted a cross-sectional study from March 2017 to July 2018 at our neurourology and urodynamics outpatient clinic, among 120 women with urinary incontinence symptoms. Based on medical history, physical exam and urodynamic assessment, participants were divided into groups with stress-, urgency- and mixed urinary incontinence. Several quality of life and...
Source: Medicina (Kaunas) - June 3, 2019 Category: Universities & Medical Training Authors: Radoja I, Degmečić D Tags: Medicina (Kaunas) Source Type: research

Left Atrial Function Is Improved in Short-Term Follow-Up after Catheter Ablation of Outflow Tract Premature Ventricular Complexes.
S, Tenekecioglu E Abstract Background: Association of premature ventricular complexes (PVC) with left ventricular systolic dysfunction (LVSD) and efficacy of catheter ablation treatment have been demonstrated in studies. The role of left atrial (LA) mechanics in the etiopathogenesis of PVC-induced cardiomyopathy (PVC-CMP) as well as changes in LA mechanics with catheter ablation have not been studied before. Methods: A total number of 61 patients (Mean Age 43 ± 3) with idiopathic outflow tract (OT) PVCs undergoing radiofrequency catheter ablation (RFCA) were enrolled. ECG, 24 h Holter, and echocardiographic...
Source: Medicina (Kaunas) - June 3, 2019 Category: Universities & Medical Training Authors: Kanat S, Mutluer FO, Tütüncü A, Karaduman BD, Bozkaya VO, Keskin M, Uslu A, Çay S, Tenekecioglu E Tags: Medicina (Kaunas) Source Type: research

Gastric Adenocarcinoma Associated with Acute Endocarditis of the Aortic Valve and Coronary Artery Disease in a 61-Year-Old Male with Multiple Comorbidities-Combined Surgical Management-Case Report.
Abstract The case of a 61-year-old male with a recent total gastrectomy for a hemorrhagic gastric tumor is presented, with the important co-morbidities of type II diabetes mellitus requiring insulin, chronic hepatitis C with liver dysfunction, stage II essential hypertension, chronic stage III renal disease peripheral type II aorto-iliac disease with stage II ischemia of both legs, and chronic anemia. About one month following the gastrectomy, the patient presented with fever and acute inflammatory syndrome. Severe aortic insufficiency, aortic valvular vegetations, and positive blood cultures with Staphylococcus s...
Source: Medicina (Kaunas) - June 3, 2019 Category: Universities & Medical Training Authors: Moldovan H, Popescu D, Buliga T, Filip A, Antoniac I, Gheorghiţӑ D, Molnar A Tags: Medicina (Kaunas) Source Type: research

A Simple Index for Nonalcoholic Steatohepatitis-HUFA-Based on Routinely Performed Blood Tests.
Conclusion: We suggest a simple non-invasive predictive index HUFA that encompasses four easily available parameters (HOMA-IR, uric acid, ferritin and ALT) to identify patients with NASH, which may reduce the need for a liver biopsy on a routine basis in patients with NAFLD. PMID: 31163711 [PubMed - in process] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - June 3, 2019 Category: Universities & Medical Training Authors: Culafic M, Vezmar Kovacevic S, Dopsaj V, Stulic M, Vlaisavljevic Z, Miljkovic B, Culafic D Tags: Medicina (Kaunas) Source Type: research

Immunoinformatics Based Study of T Cell Epitopes in Zea m 1 Pollen Allergen.
Conclusions: The T cell epitopes identified in this study provide insight into a peptide-based vaccine for a type I hypersensitivity reaction induced by Zea m 1 grass pollen allergenic protein. PMID: 31159395 [PubMed - in process] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - June 1, 2019 Category: Universities & Medical Training Authors: Basu A Tags: Medicina (Kaunas) Source Type: research

Self-Efficacy and Emotional Intelligence as Predictors of Perceived Stress in Nursing Professionals.
Conclusion: The results of this study suggest that one way to reduce stress in professionals would be to help them improve their emotional intelligence in programs (tailored to consider particularities of either sex) within the framework of nursing, enabling them to develop and acquire more effective stress coping strategies, which would alleviate distress and increase the wellbeing of health professionals. PMID: 31159453 [PubMed - in process] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - June 1, 2019 Category: Universities & Medical Training Authors: Molero Jurado MDM, Pérez-Fuentes MDC, Oropesa Ruiz NF, Simón Márquez MDM, Gázquez Linares JJ Tags: Medicina (Kaunas) Source Type: research

Imbalance of Controlled Death in Peripheral Blood Lymphocytes in Crohn's Disease and Ulcerative Colitis.
Conclusions: Our research has shown a simultaneous increase in the expression of the anti-apoptotic BCL2 gene and the proapoptotic BAX gene, which suggests the dysregulation of apoptosis mechanisms in IBD. Significantly higher expression of BAX and BCL2 in UC patients in remission as compared to CD may suggest differences in these diseases in terms of prognosis and treatment. Our results may suggest that an underlying imbalance in factors controlling apoptosis in peripheral blood lymphocytes may be the response of the immune system to inflammation of the intestinal mucosa. Modulation of apoptosis may become an important th...
Source: Medicina (Kaunas) - May 31, 2019 Category: Universities & Medical Training Authors: Dudzińska E, Szymona K, Gil-Kulik P, Chomik P, Świstowska M, Gryzińska M, Kocki J Tags: Medicina (Kaunas) Source Type: research

Early Clinical Features, Time to Secondary Progression, and Disability Milestones in Polish Multiple Sclerosis Patients.
Conclusions: Early clinical features of MS are important in determining the disease variant, the time to transition from RRMS to SPMS, as well as predicting the disability accumulation of patients. Despite the small differences regarding the first MS symptoms, the disability outcomes in the cohort of Polish patients are similar to other regions of the world. PMID: 31159275 [PubMed - in process] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - May 31, 2019 Category: Universities & Medical Training Authors: Rzepiński Ł, Zawadka-Kunikowska M, Maciejek Z, Newton JL, Zalewski P Tags: Medicina (Kaunas) Source Type: research

GLP-1 Receptor Agonists and Kidney Protection.
Abstract Type 2 diabetes mellitus (T2DM) is the leading cause of chronic kidney disease (CKD). Diabetic nephropathy (DN) is determined by specific pathological structural and functional alterations of the kidneys in patients with diabetes, and its clinical manifestations are albuminuria and decline of glomerular filtration rate (GFR). Apart from renin-angiotensin-aldosterone system (RAAS) inhibitors, no other drugs are currently available as therapy for diabetic kidney disease (DKD). Glucagon-like peptide-1 receptor (GLP-1R) agonists are a new class of anti-hyperglycemic drugs which have been demonstrated to preve...
Source: Medicina (Kaunas) - May 31, 2019 Category: Universities & Medical Training Authors: Greco EV, Russo G, Giandalia A, Viazzi F, Pontremoli R, De Cosmo S Tags: Medicina (Kaunas) Source Type: research

Migration of Ethylene Vinyl Alcohol Co-Polymer in the Urinary Tract Successfully Managed.
We report a unique case of embolization of a renal pseudoaneurysm and migration of EVOH in the urinary tract. Retrograde trans-urethral removal of the migrated embolic agent was successfully performed. Our case report indicates that EVOH may not be appropriate when a fistula with renal calyx is suspected, even if its migration in the urinary tract may be managed. PMID: 31159307 [PubMed - in process] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - May 31, 2019 Category: Universities & Medical Training Authors: Ierardi AM, Pesapane F, Arrichiello A, Fontana F, Piacentino F, Carrafiello G Tags: Medicina (Kaunas) Source Type: research

Severe Abnormalities of Lens Epithelial Cells in Exfoliation Syndrome: A Transmission Electron Microscopy Study of Patients with Age-Related Cataract.
T Abstract Background and objectives: The aim of this study was to examine via electron microscopy the lens epithelial cells in age-related cataracts and compare the findings between patients with and without exfoliation syndrome, in the Greek population. Materials and Methods: Twenty-one patients with age-related cataracts, older than 60 years, were included in the study. Eleven of them also suffered from exfoliation syndrome. Anterior lens capsules, obtained during phacoemulsification, were examined with a transmission electron microscope. Results: In all cases, ultrastructural features of diffuse intracellular ...
Source: Medicina (Kaunas) - May 31, 2019 Category: Universities & Medical Training Authors: Sorkou KΝ, Manthou ME, SoultanaMeditskou, Ziakas N, Tsaousis KT, Tsinopoulos IT Tags: Medicina (Kaunas) Source Type: research

Clinicians' Perceived Understanding of Biostatistical Results in the Medical Literature: A Cross-Sectional Study.
Conclusions: High perceived understanding was significantly associated with clinicians' confidence in interpreting statistical concepts and familiarity with different statistical methods. Our findings form a platform to understand clinicians' ability to appraise rigorous biostatistical results in the medical literature for the retrieval of evidence-based data to be used in routine clinical practice. PMID: 31151263 [PubMed - in process] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - May 30, 2019 Category: Universities & Medical Training Authors: Ganasegeran K, Ch'ng ASH, Jamil MFA, Looi I Tags: Medicina (Kaunas) Source Type: research

Evaluation of Atrial Electromechanical Delay in Children with Obesity.
;neş H Abstract Background and Objective: Childhood obesity is one of the worldwide health problems with an increasing prevalence and accompanied by severe morbidity and mortality. It is a serious predisposing risk factor especially for the development of cardiovascular diseases and arrhythmias. Electromechanical delay (EMD) is known to be a predictor for the development of atrial fibrillation (AF). Our study aims to investigate whether EMD, which is a predictor of AF, prolongs in obese children or not. MATERIAL AND METHODS: The study included 59 obese patients aged between 8-18 years and 38 healthy patients...
Source: Medicina (Kaunas) - May 30, 2019 Category: Universities & Medical Training Authors: Temiz F, Güneş H, Güneş H Tags: Medicina (Kaunas) Source Type: research