Follow-Up Analysis of Pulmonary Function, Exercise Capacity, Radiological Changes, and Quality of Life Two Months after Recovery from SARS-CoV-2 Pneumonia
Medicina (Kaunas). 2021 Jun 3;57(6):568. doi: 10.3390/medicina57060568.ABSTRACTBackground and objective: According to the World Health Organization (WHO), more than 100 million people have already recovered from SARS-CoV-2 infection. Therefore, it is imperative to understand the possible outcomes of COVID-19. The aim of our study was to evaluate pulmonary function, exercise capacity, residual radiological changes, and health-related quality of life (HRQoL) at follow-up in a cohort of SARS-CoV-2 pneumonia survivors. Materials and Methods: Patients with SARS-CoV-2 infection and radiologically confirmed lung injury, with no c...
Source: Medicina (Kaunas) - July 2, 2021 Category: Universities & Medical Training Authors: Edita Strumiliene Ingrida Zeleckiene Rytis Bliudzius Arturas Samuilis Tadas Zvirblis Birute Zablockiene Arunas Strumila Vygantas Gruslys Laura Malinauskiene Vytautas Kasiulevicius Ligita Jancoriene Source Type: research

A Comparative Study of Antioxidative Activity of Saliva in Children and Young Teenagers with and without Gingivitis
Medicina (Kaunas). 2021 Jun 3;57(6):569. doi: 10.3390/medicina57060569.ABSTRACTObjectives: The aim of this study was to compare the values of total antioxidant capacity (TAC), catalase (CAT) and glutathione peroxidase (GPX) in the saliva of children and young teenagers with and without gingivitis. Materials and Methods: A total of 120 children and young teenagers of the mean age of 12.2 participated in the research. Gingival condition was assessed using the Löe and Silness Gingival Index. The subjects were divided into groups of those without gingivitis and those with gingivitis. Samples of unstimulated saliva were co...
Source: Medicina (Kaunas) - July 2, 2021 Category: Universities & Medical Training Authors: Olivera Tri čković Janjić Tatjana Cvetkovi ć Branislava Stojkovi ć Ra ša Mladenović Mila Janji ć Ranković Source Type: research

Planning Implementation Success of Syncope Clinical Practice Guidelines in the Emergency Department Using CFIR Framework
Conclusions: Effective multifaceted implementation strategies that target individuals, teams, and healthcare systems can be employed to plan successful implementation and promote adherence to syncope CPGs.PMID:34204986 | PMC:PMC8228757 | DOI:10.3390/medicina57060570 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - July 2, 2021 Category: Universities & Medical Training Authors: Jing Li Susan S Smyth Jessica M Clouser Colleen A McMullen Vedant Gupta Mark V Williams Source Type: research

A Five-Year Survey for Plastic Surgery Malpractice Claims in Rome, Italy
Conclusions: Our data confirm that the analyzed branch has a high litigation rate, with a prevalence of convictions for cosmetic procedures over reconstructive ones, both for malpractice and for violation of the informed consent. Plastic surgery is also confirmed among those branches in which the professionals are more frequently sued compared to health institutions.PMID:34205015 | PMC:PMC8230183 | DOI:10.3390/medicina57060571 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - July 2, 2021 Category: Universities & Medical Training Authors: Alessandro Feola Chiara Minotti Daniela Marchetti Marco Caricato Gabriella Teresa Capolupo Luigi Tonino Marsella Giuseppe La Monaca Source Type: research

A Decade of Wishes-Changes in Maternal Preference of the Mode of Delivery among Polish Women over the Last Decade
The objective of the study was to obtain information about women's preferences of the mode of delivery and knowledge about the cesarean section and its' consequences. Materials and Methods: The study was based on a survey filled in by 1175 women in 2010 and 1033 women in 2020. Respondents were asked about their preference of mode of delivery, possible factors influencing their decision and their knowledge about risks and benefits of cesarean section. Results: There was a significant increase in the rate of women who declared cesarean section as their preferred mode of delivery, from 43.97% in 2010 to 56.03% in 2020 (p
Source: Medicina (Kaunas) - July 2, 2021 Category: Universities & Medical Training Authors: Agnieszka Jodzis Maciej Wal ędziak Krzysztof Czajkowski Anna R óżańska-Walędziak Source Type: research

Vital Pulp Therapy in Permanent Mature Posterior Teeth with Symptomatic Irreversible Pulpitis: A Systematic Review of Treatment Outcomes
Conclusions: The reviewed 12 articles reported favorable outcomes of the VPT performed with HCSCs in permanent mature posterior teeth with symptomatic irreversible pulpitis, with radiographic success in the range of 81 to 90%. Two articles suggested comparable outcomes of the VPT and root canal treatment. Universal case selection and outcome criteria needs to be established for VPT when considered as an alternative to NSRCT. This evidence supports the need for further research comparing longer-term outcomes of both of the treatment modalities.PMID:34205149 | PMC:PMC8228104 | DOI:10.3390/medicina57060573 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - July 2, 2021 Category: Universities & Medical Training Authors: Jo ão Miguel Santos Joana F Pereira Andr éa Marques Diana B Sequeira Shimon Friedman Source Type: research

Risk Analysis of Needle Injury to the Long Thoracic Nerve during Ultrasound-Guided C7 Selective Nerve Root Block
Conclusion: Our findings suggest a high potential for LTN injury during US-guided C7 SNRB. The clear visualization of LTNs in the US images implies that US guidance may help avoid nerve damage and make the procedure safer. When performing US-guided C7 SNRB, physicians should take into consideration the location of the LTN.PMID:34205371 | PMC:PMC8235341 | DOI:10.3390/medicina57060635 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - July 2, 2021 Category: Universities & Medical Training Authors: Seok Kang Ha-Mok Jeong Beom-Suk Kim Joon-Shik Yoon Source Type: research

Tumor Chemosensitivity Assays Are Helpful for Personalized Cytotoxic Treatments in Cancer Patients
Medicina (Kaunas). 2021 Jun 19;57(6):636. doi: 10.3390/medicina57060636.ABSTRACTTumor chemosensitivity assays (TCAs), also known as drug response assays or individualized tumor response tests, have been gaining attention over the past few decades. Although there have been strong positive correlations between the results of these assays and clinical outcomes, they are still not considered routine tests in the care of cancer patients. The correlations between the assays' results (drug sensitivity or resistance) and the clinical evaluations (e.g., response to treatment, progression-free survival) are highly promising. However...
Source: Medicina (Kaunas) - July 2, 2021 Category: Universities & Medical Training Authors: Engin Ulukaya Didem Karakas Konstantinos Dimas Source Type: research

Mild Fetal Tricuspid Regurgitation in the First Trimester as a Predictor of Perinatal Outcomes
Conclusions: Mild fetal TR observed in the first trimester is negatively associated with fetal growth and the amniotic fluid index at term but not with other adverse pregnancy or perinatal outcomes due to abnormal placentation.PMID:34205479 | PMC:PMC8233995 | DOI:10.3390/medicina57060637 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - July 2, 2021 Category: Universities & Medical Training Authors: Ji-Eun Park Hyen-Chul Jo Seon-Mi Lee Jong-Chul Baek In-Ae Cho Soon-Ae Lee Source Type: research

A Bibliometric Analysis of Fragility Fractures: Top 50
Conclusions: This bibliometric review shows the growing interest in fragility fractures and raises awareness that more high quality and interdisciplinary studies are needed.PMID:34205638 | PMC:PMC8233744 | DOI:10.3390/medicina57060639 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - July 2, 2021 Category: Universities & Medical Training Authors: Nicolas Vuillemin Hans-Christoph Pape Pol Maria Rommens Kurt Lippuner Klaus-Arno Siebenrock Marius Johann Keel Johannes Dominik Bastian Source Type: research

Obstructive Sleep Apnea and Periodontal Disease: A Systematic Review
Conclusions: There is low evidence of a possible association between OSAS and periodontitis. The pathophysiological mechanism, cause-effect, or dose-response relationship are still unclear. Further studies are needed and should use a precise classification of OSAS subjects, while the new classification of periodontitis from the World Workshop of Chicago 2017 should be used for the periodontal assessment.PMID:34205812 | PMC:PMC8235051 | DOI:10.3390/medicina57060640 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - July 2, 2021 Category: Universities & Medical Training Authors: Daniela Lembo Francesco Caroccia Chiara Lopes Francesco Moscagiuri Bruna Sinjari Michele D'Attilio Source Type: research

The Difference of Cholesterol, Platelet and Cortisol Levels in Patients Diagnosed with Chronic Heart Failure with Reduced Ejection Fraction Groups According to Neutrophil Count
Medicina (Kaunas). 2021 Jun 1;57(6):557. doi: 10.3390/medicina57060557.ABSTRACTBackground and Objectives: It is known that neutrophils are involved in the pro-inflammatory processes and thus, can have a great impact on the pathophysiology of heart failure (HF). Moreover, hypercholesterolemia heightens neutrophil production, thereby accelerating cardiovascular inflammation. However, there is a lack of information about the relation of low inflammation to the state of stress, hypercholesterolemia, and pro-thrombotic statement in patients with chronic HF. Therefore, we aimed to determine whether platelet, cholesterol and cort...
Source: Medicina (Kaunas) - July 2, 2021 Category: Universities & Medical Training Authors: Au šra Mongirdienė Jolanta Laukaitien ė Vilius Skipskis Lolita Kur švietienė Julius Liobikas Source Type: research

May We Use Non-Invasive Indices of Aortic Stiffness and Endothelial Glycocalyx as Biomarkers for Idiopathic Pulmonary Artery Hypertension Follow-Up?
We present the 3-years follow-up of a female IPAH patient. We propose aortic stiffness and endothelial glycocalyx indices as non-invasive markers of either improvement or deterioration of IPAH disease.PMID:34205859 | PMC:PMC8230127 | DOI:10.3390/medicina57060558 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - July 2, 2021 Category: Universities & Medical Training Authors: Helen Triantafyllidi Dionysia Birmpa Dimitrios Benas Ignatios Ikonomidis Antonis Schoinas Paraskevi Trivilou Frantzeska Frantzeskaki Stylianos E Orfanos Source Type: research

Effect of Blue Light Filtering Intraocular Lenses on Visual Perception
Conclusion: No significant differences (p> 0.05) were found in any of the tested parameters between the analyzed groups. Slight shift in color vision was observed, although not statistically significant.PMID:34206059 | PMC:PMC8226562 | DOI:10.3390/medicina57060559 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - July 2, 2021 Category: Universities & Medical Training Authors: Ivajlo Popov Denisa Jurenova Jela Valaskova Diego Sanchez-Chicharro Jana Stefanickova Iveta Waczulikova Vladimir Krasnik Source Type: research

To Enhance or Not to Enhance? The Role of Contrast Medium < sup > 18 < /sup > F-FDG PET/CT in Recurrent Ovarian Carcinomas
Conclusions: PET/ceCT does not perform better than PET/ldCT but can occasionally clarify doubtful peritoneal findings on PET/ldCT. To avoid unnecessary dose to the patient, PET/ceCT should be excluded in selected cases.PMID:34206116 | PMC:PMC8229308 | DOI:10.3390/medicina57060561 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - July 2, 2021 Category: Universities & Medical Training Authors: Michela Massollo Francesco Fiz Gianluca Bottoni Martina Ugolini Francesco Paparo Cristina Puppo Nicoletta Provinciali Massimiliano Iacozzi Vania Altrinetti Angelina Cistaro Manlio Cabria Andrea DeCensi Giorgio Treglia Arnoldo Piccardo Source Type: research

Diabetes Mellitus Promotes Smooth Muscle Cell Proliferation in Mouse Ureteral Tissue through the P-ERK/P-JNK/VEGF/PKC Signaling Pathway
Conclusions: Hyperproliferation of ureteral smooth muscle was observed in DM mice, but not in normal mice. The pathways mediated by P-ERK, P-JNK, VEGF, and PKC may play an important role in pathological ureteral conditions.PMID:34206139 | PMC:PMC8230221 | DOI:10.3390/medicina57060560 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - July 2, 2021 Category: Universities & Medical Training Authors: Taesoo Choi Jeong-Woo Lee Su-Kang Kim Koo-Han Yoo Source Type: research

Inhibitory Effect of < em > Asplenium incisum < /em > on Bacterial Growth, Inflammation, and Osteoclastogenesis
This study aimed to investigate the potential of A. incisum extract as a phytotherapeutic candidate for improving periodontal diseases by assessing its antibacterial, anti-inflammatory, and anti-osteoclastogenic activities. Materials and Methods: The inhibition of proliferation of P. gingivalis by A. incisum and the sustainability of its antibacterial activity were evaluated in this study. The production of inflammatory cytokines (tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6)) and nitric oxide (NO) from lipopolysaccharide-stimulated RAW 264.7 cells was assessed using an enzyme-linked immunosorbent as...
Source: Medicina (Kaunas) - July 2, 2021 Category: Universities & Medical Training Authors: Seong-Hee Moon Ju-Lee Son Seong-Jin Shin Seung-Han Oh Seong-Hwan Kim Ji-Myung Bae Source Type: research

Current Evidence about Developmental Dysplasia of the Hip in Pregnancy
In conclusion, hip dysplasia is not associated with high-risk complications during pregnancy or with increased difficulty in vaginal delivery.PMID:34206824 | PMC:PMC8305660 | DOI:10.3390/medicina57070655 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - July 2, 2021 Category: Universities & Medical Training Authors: Anca Angela Simionescu Monica Mihaela Cirstoiu Catalin Cirstoiu Ana Maria Alexandra Stanescu Bogdan Cre țu Source Type: research

Post-Prescription Audit Plus Beta-D-Glucan Assessment Decrease Echinocandin Use in People with Suspected Invasive Candidiasis
Conclusions: An intervention based on pre-prescription restriction and post-prescription audit when combined with BDG measurement is effective in optimizing antifungal therapy by significantly reducing excessive treatment duration.PMID:34206911 | PMC:PMC8306264 | DOI:10.3390/medicina57070656 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - July 2, 2021 Category: Universities & Medical Training Authors: Rita Murri Sara Lardo Alessio De Luca Brunella Posteraro Riccardo Torelli Giulia De Angelis Francesca Giovannenze Francesco Taccari Lucia Pavan Lucia Parroni Maurizio Sanguinetti Massimo Fantoni Source Type: research

Effect of Heel-First Strike Gait on Knee and Ankle Mechanics
Conclusions: The modification of gait pattern including heel-first strike pattern can reduce the mechanical load applied to the knee, while improving the extensibility of gastro-soleus muscle complex.PMID:34206943 | PMC:PMC8304808 | DOI:10.3390/medicina57070657 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - July 2, 2021 Category: Universities & Medical Training Authors: Shirin Aali Farhad Rezazadeh Georgian Badicu Wilhelm Robert Grosz Source Type: research

Association of Urinary Dickkopf-3 with Residual Renal Function Decline in Patients Undergoing Peritoneal Dialysis
This study included 36 PD patients who underwent multiple peritoneal equivalent tests during 2011-2021. The relationship between baseline clinical characteristics and the subsequent annual rate of Kt/V decline was investigated. Results: The annual rate of renal Kt/V decline was 0.29 (range: 0.05-0.48), which correlated with renal Kt/V (r = 0.55, p = 0.0005) and 24 h urinary DKK-3 excretion (r = 0.61, p
Source: Medicina (Kaunas) - July 2, 2021 Category: Universities & Medical Training Authors: Kenta Torigoe Kumiko Muta Kiyokazu Tsuji Ayuko Yamashita Miki Torigoe Shinichi Abe Yuki Ota Hiroshi Mukae Tomoya Nishino Source Type: research

The Riga East University Hospital Stroke Registry-An Analysis of 4915 Consecutive Patients with Acute Stroke
Conclusions: Our stroke registry data are comparable to those of other major registries. Analysis of stroke registry data is important for improving stroke care and obtaining additional information for stroke studies.PMID:34207100 | PMC:PMC8233796 | DOI:10.3390/medicina57060632 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - July 2, 2021 Category: Universities & Medical Training Authors: Guntis Karelis Madara Micule Evija Klavina Iveta Haritoncenko Ilga Kikule Biruta Tilgale Inese Polaka Source Type: research

COVID-19 Causing Hypotension in Frail Geriatric Hypertensive Patients?
This report presents the cases of five frail geriatric patients (avg. age 78.3 (±6.4) years) with sarcopenia and controlled hypertension (office BP
Source: Medicina (Kaunas) - July 2, 2021 Category: Universities & Medical Training Authors: Marek Koudelka Eli ška Sovová Source Type: research

Lithium Medication in Pregnancy and Breastfeeding-A Case Series
Medicina (Kaunas). 2021 Jun 18;57(6):634. doi: 10.3390/medicina57060634.ABSTRACTLithium salts are the first-line prophylaxis treatment for bipolar disorder in most guidelines. The majority of bipolar women are treated with mood stabilizers at the time they wish to get pregnant. One reason for this is the rising average age at first childbirth, at least in the high-income countries, which increases in general the likelihood of a medication with psychotropic drugs. Previously, lithium exposition during pregnancy was thought to strongly increase the risk of severe cardiac malformation. However, recent studies only point to a ...
Source: Medicina (Kaunas) - July 2, 2021 Category: Universities & Medical Training Authors: Andrea Gehrmann Katrin Fiedler Anna Linda Leutritz Carolin Koreny Sarah Kittel-Schneider Source Type: research

Elevated Procalcitonin Is Positively Associated with the Severity of COVID-19: A Meta-Analysis Based on 10 Cohort Studies
Medicina (Kaunas). 2021 Jun 9;57(6):594. doi: 10.3390/medicina57060594.ABSTRACTBackground and Objectives: Procalcitonin (PCT) is positively associated with the severity of COVID-19 (including severe, critical, or fatal outcomes), but some of the confounding factors are not considered. The aim of this meta-analysis was to estimate the adjusted relationship between elevated procalcitonin on admission and the severity of COVID-19. Materials and Methods: We searched 1805 articles from PubMed, Web of Science, and Embase databases up to 2 April 2021. The articles were selected which reported the adjusted relationship applying mu...
Source: Medicina (Kaunas) - July 2, 2021 Category: Universities & Medical Training Authors: Yue Shen Cheng Cheng Xue Zheng Yuefei Jin Guangcai Duan Mengshi Chen Shuaiyin Chen Source Type: research

The Challenges of Children with Bipolar Disorder
Medicina (Kaunas). 2021 Jun 11;57(6):601. doi: 10.3390/medicina57060601.ABSTRACTChildhood onset bipolar disorder (CO-BD) presents a panoply of difficulties associated with early recognition and treatment. CO-BD is associated with a variety of precursors and comorbidities that have been inadequately studied, so treatment remains obscure. The earlier the onset, the longer is the delay to first treatment, and both early onset and treatment delay are associated with more depressive episodes and a poor prognosis in adulthood. Ultra-rapid and ultradian cycling, consistent with a diagnosis of BP-NOS, are highly prevalent in the y...
Source: Medicina (Kaunas) - July 2, 2021 Category: Universities & Medical Training Authors: Robert M Post Heinz Grunze Source Type: research

Prognostic Value of Cortisol Index of Endobiogeny in Acute Myocardial Infarction Patients
Conclusions: The cortisol index derived from the global living systems theory of Endobiogeny is more predictive of mortality than serum cortisol. Moreover, a combined assessment of cortisol index and Troponin I during AMI offers more accurate risk stratification of mortality risk than troponin alone.PMID:34208003 | PMC:PMC8230642 | DOI:10.3390/medicina57060602 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - July 2, 2021 Category: Universities & Medical Training Authors: Rima Braukyliene Kamyar Hedayat Laura Zajanckauskiene Martynas Jurenas Ramunas Unikas Ali Aldujeli Osvaldas Petrokas Vytautas Zabiela Rasa Steponaviciute Astra Vitkauskiene Brigita Hedayat Sandrita Simonyte Vaiva Lesauskaite Jean Claude Lapraz Diana Zalia Source Type: research

Evaluation of Patients with Syncope in the Emergency Department: How to Adjust Pharmacological Therapy
Medicina (Kaunas). 2021 Jun 11;57(6):603. doi: 10.3390/medicina57060603.ABSTRACTThe rate of syncope in the Emergency Department ranges between 0.9 and 1.7%. Syncope is mostly related to a underlying reflex or orthostatic mechanism. A bradycardic or a hypotensive phenotype, may be identified. The latter is the most common and could be constitutional or drug induced. Consequently, obtaining an accurate drug history is an important step of the initial assessment of syncope. As anti-hypertensive medication might be responsible for orthostatic hypotension, managing hypertension in patients with syncope requires finding an ideal...
Source: Medicina (Kaunas) - July 2, 2021 Category: Universities & Medical Training Authors: Martina Rafanelli Giuseppe Dario Testa Giulia Rivasi Andrea Ungar Source Type: research

NOX2 Activation in COVID-19: Possible Implications for Neurodegenerative Diseases
Medicina (Kaunas). 2021 Jun 11;57(6):604. doi: 10.3390/medicina57060604.ABSTRACTCoronavirus disease 2019 (COVID-19) is a rapidly spreading contagious infectious disease caused by the pathogen severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), that primarily affects the respiratory tract as well as the central nervous system (CNS). SARS-CoV-2 infection occurs through the interaction of the viral protein Spike with the angiotensin II receptor (ACE 2), leading to an increase of angiotensin II and activation of nicotinamide adenine dinucleotide phosphate oxidase2 (NOX2), resulting in the release of both reactive oxy...
Source: Medicina (Kaunas) - July 2, 2021 Category: Universities & Medical Training Authors: Cinzia Sindona Giovanni Schepici Valentina Contestabile Placido Bramanti Emanuela Mazzon Source Type: research

Prevalence, Epidemiological Characteristics, and Pharmacotherapy of Coronary Artery Disease among Patients with Atrial Fibrillation: Data from Jo-Fib Study
This study aimed to assess the prevalence, cardiovascular risk factors, and used medications of CAD in AF patients. Materials and Methods: This retrospective, case-control study utilized data from the Jordanian Atrial Fibrillation (Jo-Fib) registry. Investigators collected clinical features, history of co-existing comorbidities, CHA2DS2-VASc, and HAS BLED scores for all AF patients aged>18 visiting 19 hospitals and 30 outpatient cardiology clinics. A multivariable binary logistic regression was used to asses for factors associated with higher odds of having CAD. Results: Out of 2000 patients with AF, 227 (11.35%) had CA...
Source: Medicina (Kaunas) - July 2, 2021 Category: Universities & Medical Training Authors: Hanna K Al-Makhamreh Mohammed Q Al-Sabbagh Ala' E Shaban Abdelrahman F Obiedat Ayman J Hammoudeh Source Type: research

Characteristics of Pedaling Muscle Stiffness among Cyclists of Different Performance Levels
Medicina (Kaunas). 2021 Jun 11;57(6):606. doi: 10.3390/medicina57060606.ABSTRACTBackground and Objectives: The aim of the present study was to compare the impact of an incremental exercise test on muscle stiffness in the rectus femoris (RF), vastus lateralis (VL), biceps femoris (BF), and gastrocnemius (GL) among road cyclists of three performance levels. Materials and Methods: The study group consisted of 35 cyclists grouped according to their performance level; elite (n = 10; professional license), sub-elite (n = 12; amateur license), and recreational (n = 13; cyclosportive license). Passive muscle stiffness was assessed...
Source: Medicina (Kaunas) - July 2, 2021 Category: Universities & Medical Training Authors: Isaac L ópez-Laval Rafel Cirer-Sastre Francisco Corbi Sebastian Sitko Source Type: research

Refractory Dry Eye Syndrome after Transconjunctival Excision of the Palpebral Lobe of the Lacrimal Gland
In this report, we describe two cases of refractory DES due to decreased total tear secretion, although only the palpebral lobes of the main lacrimal glands were biopsied.PMID:34208279 | PMC:PMC8230785 | DOI:10.3390/medicina57060608 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - July 2, 2021 Category: Universities & Medical Training Authors: Yong-Jae Lee Han-Sol Choi Seong-Jun Park Hae-Jung Sun Sun-Young Jang Source Type: research

A Review of the Significance in Measuring Preoperative and Postoperative Carcinoembryonic Antigen (CEA) Values in Patients with Medullary Thyroid Carcinoma (MTC)
Conclusions: Although CEA is not a specific biomarker of the disease in MTC, itsmeasurement is useful in assessing the progression of the disease. The embryonic origin of C cells could explain the increased CEA values in MTC.PMID:34208296 | PMC:PMC8230872 | DOI:10.3390/medicina57060609 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - July 2, 2021 Category: Universities & Medical Training Authors: Ioannis Passos Elisavet Stefanidou Soultana Meditskou-Eythymiadou Maria Mironidou-Tzouveleki Vasiliki Manaki Vasiliki Magra Styliani Laskou Stylianos Mantalovas Stelian Pantea Isaak Kesisoglou Konstantinos Sapalidis Source Type: research

Vancomycin-Induced Organizing Pneumonia: A Case Report and Literature Review
Medicina (Kaunas). 2021 Jun 11;57(6):610. doi: 10.3390/medicina57060610.ABSTRACTThe long-term administration of vancomycin has increased; however, the pulmonary adverse reactions of long-term vancomycin treatment remain under-studied. A 75-year-old male patient with vertebral osteomyelitis receiving long-term vancomycin therapy developed a fever. High resolution computed tomography showed irregular ground glass opacity and consolidation in the right upper lung. The patient developed organizing pneumonia. This occurred without peripheral eosinophilia or adverse reactions in the skin and liver. The administration of vancomyc...
Source: Medicina (Kaunas) - July 2, 2021 Category: Universities & Medical Training Authors: Young-Shin Lee Yu-Mi Lee Source Type: research

Characterization of Cytokines and Proliferation Marker Ki67 in Chronic Rhinosinusitis with Nasal Polyps: A Pilot Study
Conclusions: Decreased appearance of IL-1α, IL-4, IL-6, IL-7, IL-8, IL-10, IL-12 positive structures in the nasal epithelium with selective increase of IL-1α and IL-12 in nasal subepithelial connective tissue characterize the cytokine endotype with dysfunctional epithelial barrier and local stimulation of immune response in the connective tissue in case of chronic rhinosinusitis with polyps. Decrease of IL-6 in both-epithelium and connective tissue with strong correlation between it and IL-7 and IL-10 in connective tissue suggests significant stimulation of this regulatory cytokine and, possibly, the important ...
Source: Medicina (Kaunas) - July 2, 2021 Category: Universities & Medical Training Authors: Rudolfs Janis Viksne Gunta Sumeraga Mara Pilmane Source Type: research

On the Track of New Endoscopic Alternatives for the Treatment of Selected Gastric GISTs-A Pilot Study
Medicina (Kaunas). 2021 Jun 16;57(6):625. doi: 10.3390/medicina57060625.ABSTRACTBackground and Objectives: GISTs (Gastrointestinal stromal tumors) are the most common mesenchymal gastrointestinal tract tumours and are mainly located in the stomach. Their malignant potential depends on size, location, and type. Endoscopic techniques are a less invasive modality for patients not eligible for surgery. ESD (endoscopic submucosal dissection) is mainly used for the removal of smaller GISTs, with intraluminal growth and a more superficial location. Thus, R0 resection capability in some cases may be not sufficient, limited by tumo...
Source: Medicina (Kaunas) - July 2, 2021 Category: Universities & Medical Training Authors: Artur Raiter Katarzyna M Pawlak Katarzyna Koz łowska-Petriczko Jan Petriczko Joanna Sze łemej Anna Wiechowska-Koz łowska Source Type: research

Implant Placement after Closure of Oroantral Communication by Sinus Bone Graft Using a Collagen Barrier Membrane in the Shape of a Pouch: A Case Report and Review of the Literature
Medicina (Kaunas). 2021 Jun 16;57(6):626. doi: 10.3390/medicina57060626.ABSTRACTOro-antral communication (OAC) acts as a pathway for bacteria between the maxillary sinus and oral cavity, and is a common complication after the removal of a dental implant or extraction of a tooth from the maxillary posterior area. In the case of an untreated OAC, oro-antral fistula develops and becomes epithelialized. We aimed to introduce a treatment for OAC closure via a sinus bone grafting procedure using bone tacks and a collagen membrane with an allograft. The procedure was performed by applying an absorbable membrane made in pouch form...
Source: Medicina (Kaunas) - July 2, 2021 Category: Universities & Medical Training Authors: Jae-Ha Baek Byung-Ock Kim Won-Pyo Lee Source Type: research

The Relationship between Affect Integration and Psychopathology in Patients with Personality Disorder: A Cross-Sectional Study
Conclusion: Taken together, emotional dysfunction, as measured by the Affect Integration Inventory, appeared to be a central component of the pathological self-organization associated with personality disorder. These findings have several implications for the understanding and psychotherapeutic treatment of personality pathology. Furthermore, they highlight the importance of considering the integration of discrete affects and their specific contributions in the conceptualization and treatment of emotional dysfunction in patients with personality disorders.PMID:34208658 | PMC:PMC8234290 | DOI:10.3390/medicina57060627 (Sourc...
Source: Medicina (Kaunas) - July 2, 2021 Category: Universities & Medical Training Authors: Christina Frederiksen Ole Andr é Solbakken Rasmus Wentzer Licht Carsten Ren é Jørgensen Maria Rodrigo-Domingo Gry Kjaersdam Tell éus Source Type: research

Central Serous Chorioretinopathy and Personality Characteristics: A Systematic Review of Scientific Evidence over the Last 10 Years (2010 to 2020)
Conclusions: maladaptive personality traits might be an essential feature of the disease and may represent a possible link between psychiatric symptoms, such as insomnia, anxiety, and depression, and endocrinological patterns. Further research should use a specific assessment scale evaluating both the level of interpersonal functioning and specific maladaptive traits.PMID:34208694 | PMC:PMC8235071 | DOI:10.3390/medicina57060628 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - July 2, 2021 Category: Universities & Medical Training Authors: Giovanni Genovese Alessandro Meduri Maria Rosaria Anna Muscatello Sebastiano Gangemi Clemente Cedro Antonio Bruno Pasquale Aragona Gianluca Pandolfo Source Type: research

Continuous Intravenous Administration of Granulocyte-Colony-Stimulating Factors-A Breakthrough in the Treatment of Cancer Patients with Febrile Neutropenia
Medicina (Kaunas). 2021 Jun 30;57(7):675. doi: 10.3390/medicina57070675.ABSTRACT(1) Background: Febrile neutropenia (FN) remains one of the most challenging problems in medical oncology and is a very severe side effect of chemotherapy. Its late consequences, when it is recurrent or of a severe grade, are dose reduction and therapy delays. Current guidelines allow the administration of granulocyte-colony-stimulating factors (G-CSF) for profound FN (except for the case when a pegylated form of G-CSF is administrated with prophylactic intention) in addition to antibiotics and supportive care. (2) Methods: This is a prospectiv...
Source: Medicina (Kaunas) - July 2, 2021 Category: Universities & Medical Training Authors: C ălin Căinap S ânziana Cetean-Gheorghe Laura Ancuta Pop Daniel Corneliu Leucuta Doina Piciu Andra Mester C ătălin Vlad Cri şan Ovidiu Alexandra Gherman Cristina Cri şan Alina Bereanu Ovidiu B ălăcescu Anne Marie Constantin Irina Dicu Loredana B Source Type: research

Improved Methods for Mid-Term Blood Glucose Level Prediction Using Dietary and Insulin Logs
Conclusions: A relatively short (ca. two weeks) training sample of a continuous glucose monitor and dietary/insulin log is sufficient to provide accurate predictions. For the outpatient application in practice, a hybrid model is proposed that combines the present mid-term method with the authors' previous work for short-term predictions.PMID:34209125 | PMC:PMC8307794 | DOI:10.3390/medicina57070676 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - July 2, 2021 Category: Universities & Medical Training Authors: Rebaz A H Karim Istv án Vassányi Istv án Kósa Source Type: research

The Case for Whole-Person Integrative Care
Conclusions: Evidence for the benefit of whole-person care models exist but definitions are quite heterogenous and unfocused. There is a need for more standardization of whole-person models and more research using whole systems approaches rather than reductionistic attempts using isolated components.PMID:34209250 | PMC:PMC8307064 | DOI:10.3390/medicina57070677 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - July 2, 2021 Category: Universities & Medical Training Authors: Wayne B Jonas Elena Rosenbaum Source Type: research

Differences in Compositions of Oral and Fecal Microbiota between Patients with Obesity and Controls
Conclusions: Both oral and fecal gastrointestinal microbiota differs significantly among patients with severe obesity and lean individuals.PMID:34209298 | PMC:PMC8306358 | DOI:10.3390/medicina57070678 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - July 2, 2021 Category: Universities & Medical Training Authors: Tomasz Stefura Barbara Zapa ła Tomasz Gosiewski Oksana Skomarovska Alicja Dudek Micha ł Pędziwiatr Piotr Major Source Type: research

Effect of Intermittent Hypoxia on Metabolic Syndrome and Insulin Resistance in the General Male Population
We examined several metabolic parameters and a homeostasis model of assessment for insulin resistance index (HOMA-IR). The subjects were divided into three groups by AHI (Apnea-hyponea index): normal group (AHI
Source: Medicina (Kaunas) - July 2, 2021 Category: Universities & Medical Training Authors: Jung-Yup Lee Chan-Won Kim Kyung-Chul Lee Jae-Hyuk Lee Sung-Hun Kang Sung-Won Li Kyubo Kim Seok-Jin Hong Source Type: research

A 2021 Update on the Use of Liraglutide in the Modern Treatment of 'Diabesity': A Narrative Review
Medicina (Kaunas). 2021 Jun 29;57(7):669. doi: 10.3390/medicina57070669.ABSTRACTObesity and type 2 diabetes mellitus have become a significant public health problem in the past decades. Their prevalence is increasing worldwide each year, greatly impacting the economic and personal aspects, mainly because they frequently coexist, where the term "diabesity" may be used. The drug class of glucagon-like peptide 1 receptor agonists (GLP-1 RAs) is one of the most modern therapy options in managing these metabolic disorders. This review focuses on the effects of liraglutide, a long-acting GLP-1 RA, in diabesity and non-...
Source: Medicina (Kaunas) - July 2, 2021 Category: Universities & Medical Training Authors: Mariana Cornelia Tilinca Robert Aurelian Tiuca Alexandru Burlacu Andreea Varga Source Type: research

Can SARS-CoV-2 Induce Uterine Vascular Anomalies and Poor Contractile Response?-A Case Report
Medicina (Kaunas). 2021 Jun 29;57(7):670. doi: 10.3390/medicina57070670.ABSTRACTWe are reporting a case of a 36 year-old Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) positive hypertensive primigravida with postpartum uterine atony that required emergency subtotal hysterectomy at Saint John Hospital Bucur Maternity Bucharest. The maternity was designated as the Coronavirus Disease 2019 (COVID-19) Maternity for Bucharest and Ilfov County since March 2020. The patient was mildly symptomatic for SARS-CoV-2, infection confirmed with reverse transcription polymerase chain reaction (RT-PCR). The caesarean section ...
Source: Medicina (Kaunas) - July 2, 2021 Category: Universities & Medical Training Authors: Anca Lesnic Bashar Haj Hamoud Mircea-Octavian Poenaru Valentin-Tiberiu Moldovan Radu Chicea Romina-Marina Sima Mihai Popescu Liana Ples Source Type: research

Racial Differences in Incident Genitourinary Cancer Cases Captured in the National Cancer Database
Conclusions: Differential access to Commission on Cancer-accredited treatment facilities for racial minorities with genitourinary cancer constitutes a unique avenue for health equity research.PMID:34209546 | PMC:PMC8303448 | DOI:10.3390/medicina57070671 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - July 2, 2021 Category: Universities & Medical Training Authors: Dylan T Wolff Thomas F Monaghan Danielle J Gordon Kyle P Michelson Tashzna Jones Raymond Khargi Matthew T Smith Fenizia Maffucci Hyezo Kwun Nicholas R Suss Andrew G Winer Source Type: research

Peripheral Artery Disease and Abdominal Aortic Aneurysm: The Forgotten Diseases in COVID-19 Pandemic. Results from an Observational Study on Real-World Management
Conclusions: Lipid profiles of PAD and AAA patients were far from guideline-based targets, and medical management was suboptimal. In our center, the COVID-19 pandemic impacted on the strict surveillance required in these very high-risk patients. The achievement of guideline-based therapeutic targets would definitively confer additional significant benefits in reducing the CV risk in these patients.PMID:34209552 | PMC:PMC8307785 | DOI:10.3390/medicina57070672 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - July 2, 2021 Category: Universities & Medical Training Authors: Francesco Natale Raffaele Capasso Alfonso Casalino Clotilde Crescenzi Paolo Sangiuolo Paolo Golino Francesco S Loffredo Giovanni Cimmino Source Type: research

Training Load Measures and Biomarker Responses during a 7-Day Training Camp in Young Cyclists-A Pilot Study
Conclusions: The study suggests that a multilevel approach is suitable to quantify the internal training load and that different parameters can be used to control the training process. The biomarkers CK, BUN, and Alb are suitable for objectively quantifying the internal training load. The self-perception provides additional subjective information about the internal training load.PMID:34209610 | PMC:PMC8307195 | DOI:10.3390/medicina57070673 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - July 2, 2021 Category: Universities & Medical Training Authors: Yvonne Wahl Silvia Achtzehn Daniela Sch äfer Olstad Joachim Mester Patrick Wahl Source Type: research

Obesity May Not Be Associated with 28-Day Mortality, Duration of Invasive Mechanical Ventilation and Length of Intensive Care Unit and Hospital Stay in Critically Ill Patients with Severe Acute Respiratory Syndrome Coronavirus-2: A Retrospective Cohort Study
Medicina (Kaunas). 2021 Jun 29;57(7):674. doi: 10.3390/medicina57070674.ABSTRACTBackground and Objectives: The aim of this study was to investigate the association between obesity and 28-day mortality, duration of invasive mechanical ventilation and length of stay at the Intensive Care Unit (ICU) and hospital in patients admitted to the ICU for SARS-CoV-2 pneumonia. Materials and Methods: This was a retrospective observational cohort study in patients admitted to the ICU for SARS-CoV-2 pneumonia, in a single Dutch center. The association between obesity (body mass index> 30 kg/m2) and 28-day mortality, duration of invas...
Source: Medicina (Kaunas) - July 2, 2021 Category: Universities & Medical Training Authors: Sjaak Pouwels Dharmanand Ramnarain Emily Aupers Laura Rutjes-Weurding Jos van Oers Source Type: research