A Novel Fertility Indicator Equation Using Estradiol Levels for Assessment of Phase of the Menstrual Cycle.
Conclusions: The fertility indicator equation, a product of two sequential normalized changes in serum E2 levels with a sign indicating confidence in direction of change, is powerful in identifying the fertile phase and subsequent transition to the postovulatory phase and may serve as a useful algorithm for FAMs of family planning. PMID: 33105641 [PubMed - in process] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - October 22, 2020 Category: Universities & Medical Training Authors: Usala SJ, Trindade AA Tags: Medicina (Kaunas) Source Type: research

Evaluation of Different Positive End-Expiratory Pressures Using Supreme ™ Airway Laryngeal Mask during Minor Surgical Procedures in Children.
Evaluation of Different Positive End-Expiratory Pressures Using Supreme™ Airway Laryngeal Mask during Minor Surgical Procedures in Children. Medicina (Kaunas). 2020 Oct 21;56(10): Authors: Fiedler MO, Schätzle E, Contzen M, Gernoth C, Weiß C, Walter T, Viergutz T, Kalenka A Abstract Background and objectives: The laryngeal mask is the method of choice for airway management in children during minor surgical procedures. There is a paucity of data regarding optimal management of mechanical ventilation in these patients. The Supreme™ airway laryngeal mask offers the option to insert...
Source: Medicina (Kaunas) - October 21, 2020 Category: Universities & Medical Training Authors: Fiedler MO, Schätzle E, Contzen M, Gernoth C, Weiß C, Walter T, Viergutz T, Kalenka A Tags: Medicina (Kaunas) Source Type: research

Local Vibrational Therapy for Essential Tremor Reduction: A Clinical Study.
Conclusions: the device reduces essential tremor in some patients and is safe to use in ET. PMID: 33096872 [PubMed - as supplied by publisher] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - October 21, 2020 Category: Universities & Medical Training Authors: Abramavičius S, Venslauskas M, Vaitkus A, Gudžiūnas V, Laucius O, Stankevičius E Tags: Medicina (Kaunas) Source Type: research

Ganglion Cell Layer Thinning in Alzheimer's Disease.
-Juan P, Casado A Abstract The main advantages of optical retinal imaging may allow researchers to achieve deeper analysis of retinal ganglion cells (GC) in vivo using optical coherence tomography (OCT). Using this device to elucidate the impact of Alzheimer's disease (AD) on retinal health with the aim to identify a new AD biomarker, a large amount of studies has analyzed GC in different stages of the disease. Our review highlights recent knowledge into measuring retinal morphology in AD making distinctive between whether those studies included patients with clinical dementia stage or also mild cognitive impairme...
Source: Medicina (Kaunas) - October 21, 2020 Category: Universities & Medical Training Authors: López-de-Eguileta A, Cerveró A, Ruiz de Sabando A, Sánchez-Juan P, Casado A Tags: Medicina (Kaunas) Source Type: research

The Impact of Cesarean and Vaginal Delivery on Results of Psychological Cognitive Test in 5 Year Old Children.
Abstract Background and objectives: The impact of cesarean and vaginal delivery on cognitive development was analyzed in 5 year old children. Materials and Methods: Two cohorts of 5 year old children born in the years 2013 and 2014 in Karvina (Northern Moravia) and Ceske Budejovice (Southern Bohemia) were studied for their cognitive development related to vaginal (n = 117) and cesarean types of delivery (n = 51). The Bender Visual Motor Gestalt Test (BG test) and the Raven Colored Progressive Matrices (RCPM test) were used as psychological tests. Results: In the comparison of vaginal delivery vs. cesarean section,...
Source: Medicina (Kaunas) - October 21, 2020 Category: Universities & Medical Training Authors: Blazkova B, Pastorkova A, Solansky I, Veleminsky M, Veleminsky M, Rossnerova A, Honkova K, Rossner P, Sram RJ Tags: Medicina (Kaunas) Source Type: research

Hand Injuries in the Polish Silesian Paediatric Population-An Exploratory Cross-Sectional Study of Post-Traumatic X-rays.
Abstract Background and objectives: In the paediatric population, hand injuries are one of the most frequent injuries and the second most frequent area of fracture. It is estimated that hand injuries account for up to 23% of the trauma-related causes of emergency department visits. Not only are they a significant factor in health care costs, but they may also lead to detrimental and long-term consequences for the patient. The discrepancy observed between the published studies suggests a geographical variation in their epidemiology. The aim of this study is to determine the localisation of injuries and fractures in...
Source: Medicina (Kaunas) - October 20, 2020 Category: Universities & Medical Training Authors: Cebula M, Modlińska S, Machnikowska-Sokołowska M, Komenda J, Cebula A, Baron J, Gruszczyńska K Tags: Medicina (Kaunas) Source Type: research

Slow-Freezing Cryopreservation Ensures High Ovarian Tissue Quality Followed by In Vivo and In Vitro Methods and Is Safe for Fertility Preservation.
Conclusions: The latter method has shown that altered expression of miRNAs might be used as identifiers of normal/damaged tissue after further analysis. Newer, safer, and more specific approaches need to be developed in order to eliminate the risk of disease reoccurrence. PMID: 33086522 [PubMed - in process] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - October 19, 2020 Category: Universities & Medical Training Authors: Gudlevičienė Ž, Žilinskas K, Kundrotas G, Grubliauskaitė M, Baltriukienė D, Bukelskienė V Tags: Medicina (Kaunas) Source Type: research

Clinical Impact of Small Bowel Capsule Endoscopy in Obscure Gastrointestinal Bleeding.
This study retrospectively included all cases of OGIB investigated by SBCE in a tertiary care referral center, between 1st January 2016 and 31st December 2018. OGIB was defined by overt or occult gastrointestinal bleeding, with negative upper and lower endoscopy. Occult gastrointestinal bleeding was either proved by a fecal test or presumptively incriminated as a cause for IDA. DY was defined as the detection rate for what were thought to be clinically significant findings. DYs for overt and occult bleeding were assessed and compared. Gender, age, hemoglobin levels, NSAID consumption and the use of anticoagulants were reco...
Source: Medicina (Kaunas) - October 19, 2020 Category: Universities & Medical Training Authors: Singeap AM, Cojocariu C, Girleanu I, Huiban L, Sfarti C, Cuciureanu T, Chiriac S, Stanciu C, Trifan A Tags: Medicina (Kaunas) Source Type: research

Effect of Mucosal Brushing on the Serum Levels of C-Reactive Protein for Patients Hospitalized with Acute Symptoms.
This study was based in a hospital setting. Patients with acute symptoms face a life-threatening crisis and often have systemic complications during the convalescence stage. During the acute stage, oral function does not work and oral hygiene status deteriorates. A gauze or sponge brush is generally used to wipe the oral cavity; however, this process does not clean the oral cavity enough. Effective oral care requires better methods. Patients participating in this study were all hospitalized by ambulance and with acute symptoms. During the convalescence stage, patients were assigned application of mucosal brushing or wiping...
Source: Medicina (Kaunas) - October 19, 2020 Category: Universities & Medical Training Authors: Nakahodo N, Nomura Y, Oshiro T, Otsuka R, Kakuta E, Okada A, Inai Y, Takei N, Hanada N Tags: Medicina (Kaunas) Source Type: research

A Comparison of Clinical Outcomes between Endoscopic Resection and Surgical Resection in Ampullary Tumors.
Conclusions: By comparing the complication and mortality rates between ER and SR, the safety of ER was proven. PMID: 33080957 [PubMed - in process] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - October 18, 2020 Category: Universities & Medical Training Authors: Pyo JS, Son BK, Lee HY, Oh IH, Chung KH Tags: Medicina (Kaunas) Source Type: research

Heat-Related Illnesses Transported by United States Emergency Medical Services.
Conclusions: All age groups experienced HRI but particularly those 25 to 64 years old. Targeted education to increase public awareness of HRI in this age group may be needed. Region temperature most likely explains why certain divisions of the US have higher HRI frequency. Afternoons in the summer are when EMS agencies should be prepared for HRI activations. EMS units in high HRI frequency US divisions may need to carry additional treatment interventions for all HRI types. PMID: 33080867 [PubMed - in process] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - October 17, 2020 Category: Universities & Medical Training Authors: Yeargin S, Hirschhorn R, Grundstein A Tags: Medicina (Kaunas) Source Type: research

Silymarin in Combination with Vitamin C, Vitamin E, Coenzyme Q10 and Selenomethionine to Improve Liver Enzymes and Blood Lipid Profile in NAFLD Patients.
Conclusions: The administration of the association of silymarin, vitamin C, vitamin E, coenzyme Q10 and selenomethionine (Medronys epato®) was effective and well tolerated in the improvement of hepatic function of NAFLD patients. PMID: 33080906 [PubMed - in process] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - October 17, 2020 Category: Universities & Medical Training Authors: Curcio A, Romano A, Cuozzo S, Nicola AD, Grassi O, Schiaroli D, Nocera GF, Pironti M Tags: Medicina (Kaunas) Source Type: research

Modestly Elevated Serum Procalcitonin Levels in Patients with Rheumatoid Arthritis Free of Active Infection.
Abstract Background and objectives: To investigate the serum procalcitonin (PCT) levels among patients with rheumatoid arthritis (RA) without active infection compared with healthy controls and to understand the relationship of PCT with RA disease activity, and treatment received by patients. Materials and Methods: Patients aged 20 years and above with clinician-confirmed diagnosis of RA and healthy volunteers were included during regular outpatient visits, and those with active infection symptoms and signs were excluded. RA disease activity was measured using the Disease Activity Score-28 for Rheumatoid Arthritis...
Source: Medicina (Kaunas) - October 17, 2020 Category: Universities & Medical Training Authors: Ng KJ, Yu HC, Huang Tseng HY, Hsu CW, Lu MC Tags: Medicina (Kaunas) Source Type: research

Predictive Value of HPV, p53, and p16 in the Post-Treatment Evolution of Malignant Tumors of the Oropharynx and Retromolar Trigone-Oropharynx Junction.
Conclusions: Awareness of the differences in the post-treatment evolution of the patients in relation to the presence of the factors determined in our study could change the future management of such cases for ensuring improved treatment outcomes. PMID: 33076537 [PubMed - in process] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - October 15, 2020 Category: Universities & Medical Training Authors: Cobzeanu BM, Cobzeanu MD, Moscalu M, Palade OD, Rădulescu L, Negru D, Moisii LG, Cobzeanu LM, Ungureanu LB, Vonica P, Matei DV, Rusu DC, Volovaț C, Costan VV Tags: Medicina (Kaunas) Source Type: research

The Influence of Warm-Up on Body Temperature and Strength Performance in Brazilian National-Level Paralympic Powerlifting Athletes.
Conclusions: The different types of warm-up methods did not seem to provide significant differences in the force indicators in elite PP athletes. PMID: 33066417 [PubMed - in process] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - October 14, 2020 Category: Universities & Medical Training Authors: Resende MA, Vasconcelos Resende RB, Reis GC, Barros LO, Bezerra MRS, Matos DG, Marçal AC, Almeida-Neto PF, Cabral BGAT, Neiva HP, Marinho DA, Marques MC, Reis VM, Garrido ND, Aidar FJ Tags: Medicina (Kaunas) Source Type: research

Chemically Activated Cooling Vest's Effect on Cooling Rate Following Exercise-Induced Hyperthermia: A Randomized Counter-Balanced Crossover Study.
Abstract Background and objectives: Exertional heat stroke (EHS) is a potentially lethal, hyperthermic condition that warrants immediate cooling to optimize the patient outcome. The study aimed to examine if a portable cooling vest meets the established cooling criteria (0.15 °C·min-1 or greater) for EHS treatment. It was hypothesized that a cooling vest will not meet the established cooling criteria for EHS treatment. Materials and Methods: Fourteen recreationally active participants (mean ± SD; male, n = 8; age, 25 ± 4 years; body mass, 86.7 ± 10.5 kg; body fat, 16.5 ± 5.2%...
Source: Medicina (Kaunas) - October 14, 2020 Category: Universities & Medical Training Authors: Hosokawa Y, Belval LN, Adams WM, Vandermark LW, Casa DJ Tags: Medicina (Kaunas) Source Type: research

The Impact of Time-Restricted Diet on Sleep and Metabolism in Obese Volunteers.
Conclusion: The time-restricted diet was successful in weight loss for a period of 4 weeks in obese participants, which did not affect the efficiency and architecture of sleep. In addition, successful weight loss and significant improvement of sleep apnea were showed in the high-ketone group. Further research is needed to demonstrate mechanisms for weight loss, sleep apnea, and time-restricted diets. PMID: 33066554 [PubMed - in process] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - October 14, 2020 Category: Universities & Medical Training Authors: Kim H, Jang BJ, Jung AR, Kim J, Ju HJ, Kim YI Tags: Medicina (Kaunas) Source Type: research

Gastric Calcifying Fibrous Tumor: An Easy Misdiagnosis as Gastrointestinal Stromal Tumor-A Systemic Review.
This study aims to determine the best method to differentiate between gastric CFT and GIST after a systemic review and meta-analysis. Materials and Methods: A systematic search of articles using electronic databases (MEDLINE, EMBASE, and LILACS) was conducted and resulted in 162 articles with 272 CFT cases published from January 1988 to September 2019. Results: Of these cases, 272 patients, 60 patients with gastric CFT (32 men and 28 women, mean age 49.2 years) were analyzed. The mean tumor size was 2.4 cm in patients with gastric CFT. Both endoscopic ultrasound (EUS) and computed tomography (CT) findings revealed well-def...
Source: Medicina (Kaunas) - October 14, 2020 Category: Universities & Medical Training Authors: Tsai MK, Chen HY, Chuang ML, Chen CW, Jong GP Tags: Medicina (Kaunas) Source Type: research

Complement Activation on Endothelial Cell-Derived Microparticles-A Key Determinant for Cardiovascular Risk in Patients with Systemic Lupus Erythematosus?
Abstract Systemic lupus erythematosus is a classical systemic autoimmune disease that overactivates complement and can affect all organs. Early diagnosis and effective management are important in this immune-complex-mediated chronic inflammatory disease, which has a strong component of vasculitis and carries an increased risk of thrombosis, even in the absence of antiphospholipid antibodies. Development of lupus nephritis can be life limiting but is managed with dialysis and renal transplantation. Therefore, data have become available that cardiovascular risk poses a serious feature of systemic lupus erythematosus...
Source: Medicina (Kaunas) - October 13, 2020 Category: Universities & Medical Training Authors: Martin N, Tu X, Egan AJ, Stover C Tags: Medicina (Kaunas) Source Type: research

Atypical Enostoses-Series of Ten Cases and Literature Review.
Abstract Bone islands (BI; enostoses) may be solitary or occur in the setting of osteopoikilosis (multiple bone islands) and are sometimes associated with Gardner's Syndrome (osteopoikilosis and colonic polyposis). Characteristic features of bone islands are (1) absence of pain or local tenderness, (2) typical radio dense central appearance with peripheral radiating spicules (rose thorn), (3) Mean CT (computerized tomography) attenuation values above 885 Hounsfield units (HU) (4) absence of uptake on bone scan and (5) radiographic stability over time. However, when enostoses display atypical features of pain, unus...
Source: Medicina (Kaunas) - October 13, 2020 Category: Universities & Medical Training Authors: Bedard T, Mohammed M, Serinelli S, Damron TA Tags: Medicina (Kaunas) Source Type: research

Identification of Prognosis Associated microRNAs in HNSCC Subtypes Based on TCGA Dataset.
The objective of our study was to evaluate the different expression profile in HNSCC subtypes and the prognostic value that one or several miRNAs may have. Materials and Methods: Data from The Cancer Genome Atlas Program-Head and Neck Squamous Cell Carcinoma (TCGA-HNSCC) patients were collected. Differential expression analysis was conducted by edge R-powered TCGAbiolinks R package specific function. Enrichment analysis was developed with Diana Tool miRPath 3.0. Kaplan-Meier survival estimators were used, followed by log-rank tests to compute significance. Results: A total of 127 miRNAs were identified with differential ex...
Source: Medicina (Kaunas) - October 13, 2020 Category: Universities & Medical Training Authors: Petronacci CMC, García AG, Iruegas EP, Mundiña BR, Lorenzo Pouso AI, Sayáns MP Tags: Medicina (Kaunas) Source Type: research

A Comparative Analysis between Subpectoral versus Prepectoral Single Stage Direct-to-Implant Breast Reconstruction.
We report a comparative analysis of prepectoral breast reconstruction (PBR) versus subpectoral breast reconstruction to analyze their differences. Materials and Methods: Direct-to-implant (DTI) reconstruction using acellular dermal matrix (ADM) performed from February 2015 to February 2020 were retrospectively reviewed. We then compared the clinical course and postoperative outcomes of the two groups (prepectoral vs. subpectoral) based on the overall incidence of complications, pain scale, and the duration of drainage. Results: A total of 167 patients underwent unilateral DTI, with SBR 114 (68.3%) and PBR 53 (31.7%). Patie...
Source: Medicina (Kaunas) - October 13, 2020 Category: Universities & Medical Training Authors: Kim JH, Hong SE Tags: Medicina (Kaunas) Source Type: research

The Relationship between Changes in Organ-Tissue Mass and Sleeping Energy Expenditure Following Weight Change in College Sumo Wrestlers.
Conclusions: Based on our results, there is a possibility that the mass of the kidneys has an effect on the change in SEE following weight change in college Sumo wrestlers. PMID: 33066288 [PubMed - in process] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - October 13, 2020 Category: Universities & Medical Training Authors: Midorikawa T, Tanaka S, Ando T, Konishi M, Ohta M, Torii S, Sakamoto S Tags: Medicina (Kaunas) Source Type: research

Incidence of Iron Deficiency and the Role of Intravenous Iron Use in Perioperative Periods.
Abstract Iron deficiency is a major problem in worldwide populations, being more alarming in surgical patients. In the presence of absolute iron deficiency (depletion of body iron), functional iron deficiency (during intense bone marrow stimulation by endogenous or exogenous factors), or iron sequestration (acute or chronic inflammatory conditions), iron-restricted erythropoiesis can develop. This systemic review was conducted to draw attention to the delicate problem of perioperative anemia, and to provide solutions to optimize the management of anemic surgical patients. Systemic reviews and meta-analyses, clinic...
Source: Medicina (Kaunas) - October 12, 2020 Category: Universities & Medical Training Authors: Țigliș M, Neagu TP, Niculae A, Lascăr I, Grințescu IM Tags: Medicina (Kaunas) Source Type: research

Head Posture and Postural Balance in Community-Dwelling Older Adults Who Use Dentures.
Conclusions: Our findings reveal that denture use does not help with NMS, forward head maintain NMS, head posture, and postural balance in older adults. PMID: 33053657 [PubMed - in process] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - October 12, 2020 Category: Universities & Medical Training Authors: Bae Y, Park Y Tags: Medicina (Kaunas) Source Type: research

Critical Care Demand and Intensive Care Supply for Patients in Japan with COVID-19 at the Time of the State of Emergency Declaration in April 2020: A Descriptive Analysis.
Conclusions: The number of critically ill patients with COVID-19 continued to rise during the pandemic, exceeding the number of designated beds but not exceeding ICU capacity. PMID: 33053765 [PubMed - in process] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - October 12, 2020 Category: Universities & Medical Training Authors: Fujii Y, Hirota K Tags: Medicina (Kaunas) Source Type: research

Variations in Subscapularis Muscle Innervation-A Report on Case Series.
Conclusion: Accessory nerves occur rather commonly and need to be considered during surgery, nerve blocks, and imaging procedures. PMID: 33053880 [PubMed - in process] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - October 12, 2020 Category: Universities & Medical Training Authors: Siwetz M, Hammer N, Ondruschka B, Kieser DC Tags: Medicina (Kaunas) Source Type: research

The Influence of Gender and Year of Study on Stress Levels and Coping Strategies among Polish Dental.
Conclusions: The highest level of stress was found among first-year dental students. Moreover, women were characterised with higher stress levels than men. Men more often use psychoactive substances and resort to a sense of humour to cope with stress. On the other hand, women turn to religion, seek instrumental and emotional support. PMID: 33053888 [PubMed - in process] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - October 12, 2020 Category: Universities & Medical Training Authors: Mocny-Pachońska K, Trzcionka A, Doniec RJ, Sieciński S, Tanasiewicz M Tags: Medicina (Kaunas) Source Type: research

Music Therapy in Pain and Anxiety Management during Labor: A Systematic Review and Meta-Analysis.
Conclusion: Music therapy seems to have beneficial effects on pain intensity and anxiety during labor, especially for women giving birth for the first time. However, the evidence is qualified as low. PMID: 33050409 [PubMed - in process] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - October 10, 2020 Category: Universities & Medical Training Authors: Santiváñez-Acosta R, Tapia-López ELN, Santero M Tags: Medicina (Kaunas) Source Type: research

New Strategies for Treatment of Sepsis.
Abstract Sepsis represents a major global health concern and is one of the most feared complications for hospitalized patients, being the cause, directly or indirectly, of about half of all hospital deaths. According to the last definition, sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection and defined septic shock as a subset of sepsis in which underlying circulatory and cellular/metabolic abnormalities are profound enough to significantly increase mortality. Sepsis is a time-dependent disease and requires a prompt recognition and a standardized treatment. The Speci...
Source: Medicina (Kaunas) - October 10, 2020 Category: Universities & Medical Training Authors: Mirijello A, Tosoni A, On Behalf Of The Internal Medicine Sepsis Study Group Tags: Medicina (Kaunas) Source Type: research

State of the Art in Exocrine Pancreatic Insufficiency.
n-Ruiz JL, Caba O Abstract Exocrine pancreatic insufficiency (EPI) is defined as the maldigestion of foods due to inadequate pancreatic secretion, which can be caused by alterations in its stimulation, production, transport, or interaction with nutrients at duodenal level. The most frequent causes are chronic pancreatitis in adults and cystic fibrosis in children. The prevalence of EPI is high, varying according to its etiology, but it is considered to be underdiagnosed and undertreated. Its importance lies in the quality of life impairment that results from the malabsorption and malnutrition and in the increased ...
Source: Medicina (Kaunas) - October 7, 2020 Category: Universities & Medical Training Authors: Diéguez-Castillo C, Jiménez-Luna C, Prados J, Martín-Ruiz JL, Caba O Tags: Medicina (Kaunas) Source Type: research

Left Ventricular Diastolic and Systolic Functions in Patients with Hypothyroidism.
This study included 81 (age 42 ± 13 years, 92% female) patients with hypothyroidism, and 22 age and gender matched controls. All subjects underwent a detailed clinical examination followed by a complete biochemical blood analysis including thyroid function assessment and anthropometric parameters measurements. LV function was assessed by 2-dimensional, M-mode and Tissue-Doppler Doppler echocardiographic examination performed in the same day. Results: Patients had lower waist/hip ratio (p
Source: Medicina (Kaunas) - October 7, 2020 Category: Universities & Medical Training Authors: Tafarshiku R, Henein MY, Berisha-Muharremi V, Bytyçi I, Ibrahimi P, Poniku A, Elezi S, Bajraktari G Tags: Medicina (Kaunas) Source Type: research

Effects of Storage Temperature and pH on the Antifungal Effects of Commercial Oral Moisturizers against Candida Albicans and Candida Glabrata.
Conclusion: The antifungal effects of oral moisturizers against C. albicans and C. glabrata were affected by their storage temperature and pH. PMID: 33036434 [PubMed - as supplied by publisher] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - October 7, 2020 Category: Universities & Medical Training Authors: Murakami M, Harada K, Nishi Y, Shimizu T, Motoyama S, Nishimura M Tags: Medicina (Kaunas) Source Type: research

Real-World Data Analysis of Pregnancy-Associated Breast Cancer at a Tertiary-Level Hospital in Romania.
Conclusions: In this contemporary assessment of real-world treatment patterns and outcomes among patients with pregnancy-associated breast cancer, our findings were generally consistent with globally observed treatment outcomes, underscoring the need for a multidisciplinary team and reference centers. PMID: 33036248 [PubMed - as supplied by publisher] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - October 6, 2020 Category: Universities & Medical Training Authors: Simionescu AA, Horobeț A, Belaşcu L, Median DM Tags: Medicina (Kaunas) Source Type: research

What is Considered a Variation of Biomechanical Parameters in Tensile Tests of Collagen-Rich Human Soft Tissues?  - Critical Considerations Using the Human Cranial Dura Mater as a Representative Morpho-Mechanic Model.
Conclusions: It is concluded that mechanical parameters of soft tissues such as human dura mater are highly variable even if a highly standardized testing setup is involved. The tissue structure and composition appeared to be the main contributor to the scatter of the mechanical parameters. In consequence, mechanical variation of soft tissues can be defined as the extremes of a biomechanical parameter due to an uncontrollable change in tissue structure and/or the respective testing setup. PMID: 33027931 [PubMed - in process] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - October 5, 2020 Category: Universities & Medical Training Authors: Zwirner J, Scholze M, Ondruschka B, Hammer N Tags: Medicina (Kaunas) Source Type: research

Positive Anti-SSA/Ro Antibody in a Woman with SARS-CoV-2 Infection Using Immunophenotyping: A Case Report.
Abstract The clinical spectrum of novel coronavirus infection appears to be wide, encompassing asymptomatic infection, mild upper respiratory tract illness, and severe viral pneumonia, with respiratory failure and even death. Autoantibodies, especially antiphospholipid antibodies, can occur in severe infections. Other autoantibodies are seldom reported. Here, a 60-year-old female patient without dry-mouth symptoms detected positive for anti-60 kDa SSA/Ro antibodies on day 43 after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. To investigate this unique clinical case of SARS-CoV-2 infectio...
Source: Medicina (Kaunas) - October 5, 2020 Category: Universities & Medical Training Authors: Huang PI, Lin TC, Liu FC, Ho YJ, Lu JW, Lin TY Tags: Medicina (Kaunas) Source Type: research

Safety and Efficacy of Nontuberculous Mycobacteria Treatment among Elderly Patients.
Conclusion: Age may not be an obstacle for receiving the benefits of the treatment of NTM disease with a precise evaluation of patient's comorbidities. Furthermore, elderly patients without heart disease and ADL disability may have better rate of continuing the NTM treatment. The current study suggested that selecting standard regimens to treat pulmonary NTM is important for elderly patients. PMID: 33023085 [PubMed - in process] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - October 2, 2020 Category: Universities & Medical Training Authors: Uchida Y, Terada J, Homma T, Mikuni H, Hirai K, Saito H, Honda R, Sagara H Tags: Medicina (Kaunas) Source Type: research

Computed Tomography Diagnostic of Uncommon Case of Osteopetrosis in 80-Year-Old Man-Case Report.
Conclusions: The obtained densitometric data may serve for further diagnostic purposes of osteopetrosis. As documented, the severity of the osteosclerotic changes of bones were higher in this patient than in most other described cases. Moreover, radiological signs diagnosed in this patient were characteristic for all types of osteopetrosis making this case very uncommon. PMID: 33023136 [PubMed - in process] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - October 2, 2020 Category: Universities & Medical Training Authors: Krupski W, Kruk-Bachonko J, Tatara MR Tags: Medicina (Kaunas) Source Type: research

Ticagrelor as an Alternative Antiplatelet Therapy in Cardiac Patients Non-Sensitive to Aspirin.
Conclusions: Our results suggest that ticagrelor is a promising alternative therapy for patients who are non-sensitive to ASA. PMID: 33023261 [PubMed - in process] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - October 2, 2020 Category: Universities & Medical Training Authors: Khan H, Gallant R, Jain S, Al-Omran M, De Mestral C, Greco E, Wheatcroft M, Alazonni A, Abdin R, Rand ML, Ni H, Qadura M Tags: Medicina (Kaunas) Source Type: research

Non-COVID Diseases during the Pandemic: Where Have All Other Emergencies Gone?
Conclusions: the drastic reduction of ED admissions during the pandemic may be associated with fear of the virus, suggesting that patients with serious illnesses did not go to the emergency room. Moreover, there was possible misuse of the ED in the previous year. In particular, worrisome data emerged regarding a drop in cardiology and neurology admissions. Those patients postponed medical attention, possibly with fatal consequences, just for fear of exposure to COVID-19, leading to unnecessary morbidity and mortality. PMID: 33019514 [PubMed - indexed for MEDLINE] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - October 1, 2020 Category: Universities & Medical Training Authors: Ojetti V, Covino M, Brigida M, Petruzziello C, Saviano A, Migneco A, Candelli M, Franceschi F Tags: Medicina (Kaunas) Source Type: research

Hypnotics and Risk of Cancer: A Meta-Analysis of Observational Studies.
Conclusions: This meta-analysis revealed association between use of hypnotics drugs and risk of cancer. However, the use of lower dose hypnotics and shorter duration exposed to hypnotics seemed to be not associated with an increased risk of cancer. Moreover, the use of anxiolytics effect benzodiazepines seemed to be lower risk than sedatives benzodiazepines. A high heterogeneity was observed among identified studies, and results were inconsistent in some subgroups. Randomized control trials are needed to confirm the findings in the future. PMID: 33019585 [PubMed - in process] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - October 1, 2020 Category: Universities & Medical Training Authors: Peng TR, Yang LJ, Wu TW, Chao YC Tags: Medicina (Kaunas) Source Type: research

Germline BRCA Mutation and Clinical Outcomes in Breast Cancer Patients Focusing on Survival and Failure Patterns: A Long-Term Follow-Up Study of Koreans.
This study aimed to evaluate the effect of a BRCA mutation on survival and failure patterns, focusing on the risk of ipsilateral recurrence and contralateral breast cancer in patients. Materials and Methods: We retrospectively reviewed medical records of 300 patients with breast cancer who underwent genetic screening for BRCA1/2 genes and were treated at Samsung Medical Center between 1 January 2000 and 31 December 2010. Ultimately, clinical outcomes of 273 patients were analyzed. Results: The median follow-up duration was 102 months (range, 1 to 220 months). Patients with BRCA1/2-mutated tumors had a shorter 10-year disea...
Source: Medicina (Kaunas) - October 1, 2020 Category: Universities & Medical Training Authors: Kim H, Choi DH, Park W Tags: Medicina (Kaunas) Source Type: research

The Protective Effect of 5-Aminosalicylic Acid Against Non-Steroidal Anti-Inflammatory Drug-Induced Injury Through Free Radical Scavenging in Small Intestinal Epithelial Cells.
Conclusion: Our results suggested that 5-ASA protects small intestinal cells against an NSAID-induced small intestinal injury by scavenging free radicals. Therefore, 5-ASA could be a potential treatment for an NSAID-induced small intestinal injury. PMID: 33019698 [PubMed - in process] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - October 1, 2020 Category: Universities & Medical Training Authors: Jung ES, Jang HJ, Hong EM, Lim HL, Lee SP, Kae SH, Lee J Tags: Medicina (Kaunas) Source Type: research

Lipotransfer Strategies and Techniques to Achieve Successful Breast Reconstruction in the Radiated Breast.
Abstract Radiation therapy is frequently a critical component of breast cancer care but carries with it side effects that are particularly damaging to reconstructive efforts. Autologous lipotransfer has the ability to improve radiated skin throughout the body due to the pluripotent stem cells and multiple growth factors transferred therein. The oncologic safety of lipotransfer to the breasts is demonstrated in the literature and is frequently considered an adjunctive procedure for improving the aesthetic outcomes of breast reconstruction. Using lipotransfer as an integral rather than adjunctive step in the reconst...
Source: Medicina (Kaunas) - October 1, 2020 Category: Universities & Medical Training Authors: Crawford K, Endara M Tags: Medicina (Kaunas) Source Type: research

Syzygium gratum Extract Alleviates Vascular Alterations in Hypertensive Rats.
Abstract Background and Objectives: Syzygium gratum (SG) is a local vegetable and widely consumed in Thailand. Previously, a strong antioxidative effect of SG extract has been reported. The effects of SG extract on hypertension have remained unknown. The effect of SG aqueous extract on blood pressure and vascular changes were examined in L-NAME-induced hypertensive rats (LHR), and its potential active constituents were also explored. Materials and Methods: Male Sprague Dawley rats were allocated to control, L-NAME (40 mg/kg/day), L-NAME + SG (100, 300, 500 mg/kg/day), or captopril (5 mg/kg/day) groups. The compone...
Source: Medicina (Kaunas) - September 29, 2020 Category: Universities & Medical Training Authors: Pakdeechote P, Meephat S, Sakonsinsiri C, Phetcharaburanin J, Bunbupha S, Maneesai P Tags: Medicina (Kaunas) Source Type: research

Veno-Arterial-Venous Extracorporeal Membrane Oxygenation in a Critically Ill Patient with Coronavirus Disease 2019.
We report the case of a 72-year-old woman with acute respiratory distress syndrome and circulatory failure following COVID-19, who was treated with VAV-ECMO. PMID: 33008007 [PubMed - as supplied by publisher] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - September 29, 2020 Category: Universities & Medical Training Authors: Byun JH, Kang DH, Kim JW, Kim SH, Moon SH, Yang JH, Jung JJ, Cho OH, Hong SI, Ryu BH, Park HO, Choi JY, Jang IS, Kim JD, Lee CE Tags: Medicina (Kaunas) Source Type: research

Depression, Metabolic Syndrome, Serum TSH, and Vitamin D Concentrations in Rural and Urban Postmenopausal Women.
Abstract Background and objectives: Depression is a serious problem affecting people worldwide, however it more commonly concerns women. Depression reduces the quality of life and, in many cases, leads to suicide. Numerous new biological factors have been demonstrated to have an impact on the pathogenesis of depression, including vitamin D, thyroid hormones, as well as factors related to heart disease. The aim of the study was to assess the impact of serum thyroid stimulating hormone (TSH) and vitamin D concentrations as well as metabolic syndrome on the severity of depression in Polish postmenopausal women from u...
Source: Medicina (Kaunas) - September 29, 2020 Category: Universities & Medical Training Authors: Bojar I, Raczkiewicz D, Sarecka-Hujar B Tags: Medicina (Kaunas) Source Type: research

Importance of Susceptibility Rate of 'the First' Isolate: Evidence of Real-World Data.
Conclusions: When comparing cumulative antibiograms by FI with TI using real-world data, there is a large gap for critical species requiring hospital infection control. Although FI calculation is difficult, antibiograms must be calculated as FI for proper preemptive antimicrobial therapy because FI provides proper antimicrobial susceptibility data. PMID: 32998192 [PubMed - in process] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - September 27, 2020 Category: Universities & Medical Training Authors: Kim S, Yoo SJ, Chang J Tags: Medicina (Kaunas) Source Type: research

Psychogenic Non-Epileptic Status as Refractory, Generalized Hypertonic Posturing: Report of Two Adolescents.
In this report, we describe two adolescent patients who presented with prolonged PNES characterized by generalized hypertonic posturing and low levels of consciousness. Despite multiple presentation to the Emergency department, and multiple normal video-EEG, the patients were misdiagnosed with epilepsy and were inappropriately treated with antiseizure medications. Both patients presented psychiatric comorbidity, consisting of a major depressive disorder, obsessive-compulsive symptoms, social withdrawal, difficulty of social interaction, and anxious-perfectionist personality traits. The episodes of prolonged PNES gradually ...
Source: Medicina (Kaunas) - September 27, 2020 Category: Universities & Medical Training Authors: Coppola G, Pastorino GMG, Morcaldi L, D'Onofrio F, Operto FF Tags: Medicina (Kaunas) Source Type: research

Assessment of Postural Balance in Women Treated for Breast Cancer.
Abstract Background and objectives: Surgery is the primary and most effective treatment of breast cancer. Unilateral mastectomy disrupts the distribution of muscle tension between the right and the left sides of the body. The aim of the study was to evaluate postural balance in patients treated for breast cancer by mastectomy. Materials and methods: A controlled clinical study was conducted on 90 patients who have undergone surgical treatment for breast cancer (mastectomy) 5-6 years prior (Breast Group-BG). The control group (CG) consisted of 74 healthy female volunteers. Analysis of balance was performed using th...
Source: Medicina (Kaunas) - September 26, 2020 Category: Universities & Medical Training Authors: Głowacka-Mrotek I, Tarkowska M, Nowikiewicz T, Hagner-Derengowska M, Goch A Tags: Medicina (Kaunas) Source Type: research