Association between prior nephrectomy and efficacy of immune checkpoint inhibitor therapy in metastatic renal cell carcinoma - A systematic review and meta-analysis
CONCLUSIONS: These clinical data suggest that prior nephrectomy does not affect the efficacy of ICI-based regimens in mRCC relative to sunitinib.PMID:34690032 | DOI:10.1016/j.urolonc.2021.09.009 (Source: Urologic Oncology)
Source: Urologic Oncology - October 25, 2021 Category: Urology & Nephrology Authors: Raj Satkunasivam Jonathan Ca Guzman Zachary Klaassen Mary E Hall Amy N Luckenbaugh Kelvin Lim Aaron A Laviana Antonio P DeRosa Kathryn E Beckermann Brian Rini Christopher Jd Wallis Source Type: research

Assessing the diagnostic performance of systematic freehand precisionpoint transperineal prostate biopsy: Comparison of observed outcomes to PBCG nomogram predictions
Urol Oncol. 2021 Oct 20:S1078-1439(21)00412-9. doi: 10.1016/j.urolonc.2021.08.029. Online ahead of print.ABSTRACTOBJECTIVE: We assessed the diagnostic performance of freehand systematic transperineal biopsy (fTPb) by using the Prostate Biopsy Collaborative Group (PBCG) nomogram, which is a contemporary update to the PCPT nomogram.METHODS: From 1/2012 to 12/2018, fTPb was performed on consecutive men with clinical suspicion of prostate cancer. Patients included in this study had no previous diagnosis of prostate cancer, PSA between 2.5 ng/ml and 20 ng/ml, and underwent at least 12 core biopsies. In addition, those men who u...
Source: Urologic Oncology - October 24, 2021 Category: Urology & Nephrology Authors: Shaan Setia Jamaal Jackson Demetri Cendo Michael Gorin Matthew Allaway Srinivas Vourganti Source Type: research

How to optimize follow-up in patients with a suspicious multiparametric MRI and a subsequent negative targeted prostate biopsy. Results from a large, single-institution series
Urol Oncol. 2021 Oct 20:S1078-1439(21)00439-7. doi: 10.1016/j.urolonc.2021.09.015. Online ahead of print.ABSTRACTOBJECTIVE: We aimed at optimizing the follow-up for patients with a positive multiparametric magnetic resonance of the prostate (mpMRI) and a subsequent negative targeted biopsy (TBx) plus systematic biopsy (SBx).MATERIALS AND METHODS: A total of 308 men with a clinical suspicion of PCa and a positive mpMRI (PI-RADS ≥ 3) with concomitant negative systematic and targeted Bx performed at a single tertiary referral center. All patients were then followed with serial PSA measurements, digital rectal examination a...
Source: Urologic Oncology - October 24, 2021 Category: Urology & Nephrology Authors: Francesco Barletta Armando Stabile Elio Mazzone Giorgio Brembilla Gabriele Sorce Francesco Pellegrino Simone Scuderi Donato Cannoletta Giuseppe Ottone Cirulli Vito Cucchiara Giorgio Gandaglia Francesco De Cobelli Francesco Montorsi Alberto Briganti Source Type: research

Survival benefit of chemotherapy in a contemporary cohort of metastatic urachal carcinoma
Urol Oncol. 2021 Oct 19:S1078-1439(21)00432-4. doi: 10.1016/j.urolonc.2021.09.008. Online ahead of print.ABSTRACTBACKGROUND: We relied on the most contemporary Surveillance, Epidemiology, and End Results (SEER) database and tested the hypothesis that chemotherapy may improve survival in metastatic urachal carcinoma (m-UraC).MATERIAL AND METHODS: Within the SEER database (2004-2016), we identified m-UraC patients aged ≥ 18 years. Propensity score matching (PSM: cystectomy status, age and sex), Kaplan-Meier plots, cumulative incidence plots, Cox regression models and competing risks regression (CRR) models addressed overa...
Source: Urologic Oncology - October 23, 2021 Category: Urology & Nephrology Authors: Rocco Simone Flammia Francesco Chierigo Christoph W ├╝rnschimmel Benedikt Horlemann Benedikt Hoeh Gabriele Sorce Zhen Tian Costantino Leonardo Derya Tilki Carlo Terrone Fred Saad Shahrokh F Shariat Francesco Montorsi Felix Kh Chun Michele Gallucci Pierre Source Type: research

The early impact of medicaid expansion on urologic malignancies in the United States
CONCLUSIONS: Despite increases in the proportion of patients with Medicaid coverage after 2014 in states that enrolled in ME, there was not an associated change in stage at presentation or survival for patients with genitourinary malignancy.PMID:34666919 | DOI:10.1016/j.urolonc.2021.09.002 (Source: Urologic Oncology)
Source: Urologic Oncology - October 20, 2021 Category: Urology & Nephrology Authors: Xiaosong Meng Louis Vazquez Jeffrey M Howard Alexander P Kenigsberg Nirmish Singla Vitaly Margulis Aditya Bagrodia Yair Lotan Yin Xi Solomon L Woldu Source Type: research

The early impact of medicaid expansion on urologic malignancies in the United States
CONCLUSIONS: Despite increases in the proportion of patients with Medicaid coverage after 2014 in states that enrolled in ME, there was not an associated change in stage at presentation or survival for patients with genitourinary malignancy.PMID:34666919 | DOI:10.1016/j.urolonc.2021.09.002 (Source: Urologic Oncology)
Source: Urologic Oncology - October 20, 2021 Category: Urology & Nephrology Authors: Xiaosong Meng Louis Vazquez Jeffrey M Howard Alexander P Kenigsberg Nirmish Singla Vitaly Margulis Aditya Bagrodia Yair Lotan Yin Xi Solomon L Woldu Source Type: research

The early impact of medicaid expansion on urologic malignancies in the United States
CONCLUSIONS: Despite increases in the proportion of patients with Medicaid coverage after 2014 in states that enrolled in ME, there was not an associated change in stage at presentation or survival for patients with genitourinary malignancy.PMID:34666919 | DOI:10.1016/j.urolonc.2021.09.002 (Source: Urologic Oncology)
Source: Urologic Oncology - October 20, 2021 Category: Urology & Nephrology Authors: Xiaosong Meng Louis Vazquez Jeffrey M Howard Alexander P Kenigsberg Nirmish Singla Vitaly Margulis Aditya Bagrodia Yair Lotan Yin Xi Solomon L Woldu Source Type: research

The early impact of medicaid expansion on urologic malignancies in the United States
CONCLUSIONS: Despite increases in the proportion of patients with Medicaid coverage after 2014 in states that enrolled in ME, there was not an associated change in stage at presentation or survival for patients with genitourinary malignancy.PMID:34666919 | DOI:10.1016/j.urolonc.2021.09.002 (Source: Urologic Oncology)
Source: Urologic Oncology - October 20, 2021 Category: Urology & Nephrology Authors: Xiaosong Meng Louis Vazquez Jeffrey M Howard Alexander P Kenigsberg Nirmish Singla Vitaly Margulis Aditya Bagrodia Yair Lotan Yin Xi Solomon L Woldu Source Type: research

The early impact of medicaid expansion on urologic malignancies in the United States
CONCLUSIONS: Despite increases in the proportion of patients with Medicaid coverage after 2014 in states that enrolled in ME, there was not an associated change in stage at presentation or survival for patients with genitourinary malignancy.PMID:34666919 | DOI:10.1016/j.urolonc.2021.09.002 (Source: Urologic Oncology)
Source: Urologic Oncology - October 20, 2021 Category: Urology & Nephrology Authors: Xiaosong Meng Louis Vazquez Jeffrey M Howard Alexander P Kenigsberg Nirmish Singla Vitaly Margulis Aditya Bagrodia Yair Lotan Yin Xi Solomon L Woldu Source Type: research

Differences in genomic profile of high-grade urothelial carcinoma according to tumor location
CONCLUSION: Despite the small cohort size, we identified genetic differences between UTUC and BLUC in Korean patients by NGS. An understanding of the comprehensive molecular characteristics of UTUC and BLUC may be helpful in detecting candidates for targeted therapy.PMID:34663543 | DOI:10.1016/j.urolonc.2021.08.019 (Source: Urologic Oncology)
Source: Urologic Oncology - October 19, 2021 Category: Urology & Nephrology Authors: Cheol Keun Park Nam Hoon Cho Source Type: research

Differences in genomic profile of high-grade urothelial carcinoma according to tumor location
CONCLUSION: Despite the small cohort size, we identified genetic differences between UTUC and BLUC in Korean patients by NGS. An understanding of the comprehensive molecular characteristics of UTUC and BLUC may be helpful in detecting candidates for targeted therapy.PMID:34663543 | DOI:10.1016/j.urolonc.2021.08.019 (Source: Urologic Oncology)
Source: Urologic Oncology - October 19, 2021 Category: Urology & Nephrology Authors: Cheol Keun Park Nam Hoon Cho Source Type: research

The value of real-time contrast-enhanced ultrasound combined with CT enhancement in the differentiation of subtypes of renal cell carcinoma
CONCLUSION: CEUS and quantitative analysis of ROI time-intensity curve can be used for differential diagnosis of the 3 RCC subtypes. The combination of CEUS and CECT can help us differentiate RCC subtypes and is of great significance for clinical treatment strategies and prognostication.PMID:34654644 | DOI:10.1016/j.urolonc.2021.09.004 (Source: Urologic Oncology)
Source: Urologic Oncology - October 16, 2021 Category: Urology & Nephrology Authors: Rong-Xi Liang Hua Wang Hui-Ping Zhang Qin Ye Yu Zhang Mei-Juan Zheng En-Sheng Xue Yi-Fan Zhu Source Type: research

Ability of the surgical Apgar score to predict acute kidney injury following radical cystectomy
Urol Oncol. 2021 Oct 12:S1078-1439(21)00429-4. doi: 10.1016/j.urolonc.2021.09.006. Online ahead of print.ABSTRACTPURPOSE: Acute kidney injury (AKI) is a common complication after radical cystectomy (RC). Previous literature has shown that intraoperative hemodynamic instability measured via the surgical Apgar score is an independent predictor of major complications following RC. We sought to determine whether the surgical Apgar score is predictive of postoperative AKI.METHODS: We performed a retrospective review of RC patients at our institution from 2010 to 2017. Intraoperative hemodynamic instability was captured via the ...
Source: Urologic Oncology - October 16, 2021 Category: Urology & Nephrology Authors: Zaeem Lone Rebecca A Campbell Dillon Corrigan Rathika Ramkumar Pranay Hegde Abdelrahman Rahmy Prithvi B Murthy Georges Pascal Haber Nima Almassi Byron H Lee Source Type: research

The value of real-time contrast-enhanced ultrasound combined with CT enhancement in the differentiation of subtypes of renal cell carcinoma
CONCLUSION: CEUS and quantitative analysis of ROI time-intensity curve can be used for differential diagnosis of the 3 RCC subtypes. The combination of CEUS and CECT can help us differentiate RCC subtypes and is of great significance for clinical treatment strategies and prognostication.PMID:34654644 | DOI:10.1016/j.urolonc.2021.09.004 (Source: Urologic Oncology)
Source: Urologic Oncology - October 16, 2021 Category: Urology & Nephrology Authors: Rong-Xi Liang Hua Wang Hui-Ping Zhang Qin Ye Yu Zhang Mei-Juan Zheng En-Sheng Xue Yi-Fan Zhu Source Type: research

Ability of the surgical Apgar score to predict acute kidney injury following radical cystectomy
Urol Oncol. 2021 Oct 12:S1078-1439(21)00429-4. doi: 10.1016/j.urolonc.2021.09.006. Online ahead of print.ABSTRACTPURPOSE: Acute kidney injury (AKI) is a common complication after radical cystectomy (RC). Previous literature has shown that intraoperative hemodynamic instability measured via the surgical Apgar score is an independent predictor of major complications following RC. We sought to determine whether the surgical Apgar score is predictive of postoperative AKI.METHODS: We performed a retrospective review of RC patients at our institution from 2010 to 2017. Intraoperative hemodynamic instability was captured via the ...
Source: Urologic Oncology - October 16, 2021 Category: Urology & Nephrology Authors: Zaeem Lone Rebecca A Campbell Dillon Corrigan Rathika Ramkumar Pranay Hegde Abdelrahman Rahmy Prithvi B Murthy Georges Pascal Haber Nima Almassi Byron H Lee Source Type: research

The value of real-time contrast-enhanced ultrasound combined with CT enhancement in the differentiation of subtypes of renal cell carcinoma
CONCLUSION: CEUS and quantitative analysis of ROI time-intensity curve can be used for differential diagnosis of the 3 RCC subtypes. The combination of CEUS and CECT can help us differentiate RCC subtypes and is of great significance for clinical treatment strategies and prognostication.PMID:34654644 | DOI:10.1016/j.urolonc.2021.09.004 (Source: Urologic Oncology)
Source: Urologic Oncology - October 16, 2021 Category: Urology & Nephrology Authors: Rong-Xi Liang Hua Wang Hui-Ping Zhang Qin Ye Yu Zhang Mei-Juan Zheng En-Sheng Xue Yi-Fan Zhu Source Type: research

Ability of the surgical Apgar score to predict acute kidney injury following radical cystectomy
Urol Oncol. 2021 Oct 12:S1078-1439(21)00429-4. doi: 10.1016/j.urolonc.2021.09.006. Online ahead of print.ABSTRACTPURPOSE: Acute kidney injury (AKI) is a common complication after radical cystectomy (RC). Previous literature has shown that intraoperative hemodynamic instability measured via the surgical Apgar score is an independent predictor of major complications following RC. We sought to determine whether the surgical Apgar score is predictive of postoperative AKI.METHODS: We performed a retrospective review of RC patients at our institution from 2010 to 2017. Intraoperative hemodynamic instability was captured via the ...
Source: Urologic Oncology - October 16, 2021 Category: Urology & Nephrology Authors: Zaeem Lone Rebecca A Campbell Dillon Corrigan Rathika Ramkumar Pranay Hegde Abdelrahman Rahmy Prithvi B Murthy Georges Pascal Haber Nima Almassi Byron H Lee Source Type: research

Oncofid-P-B: a novel treatment for BCG unresponsive carcinoma in situ (CIS) of the bladder: Results of a prospective European Multicentre study at 15 months from treatment start
CONCLUSIONS: Oncofid-P-B is very safe, well tolerated and highly effective (75% CR) when administered weekly for up to 12 consecutive weeks (75% CR), with 40% CR still after 15 months from treatment start.PMID:34649772 | DOI:10.1016/j.urolonc.2021.07.007 (Source: Urologic Oncology)
Source: Urologic Oncology - October 15, 2021 Category: Urology & Nephrology Authors: Rodolfo Hurle Giorgio Guazzoni Piergiuseppe Colombo Armando Santoro Ottavio De Cobelli Ettore Di Trapani Gloria Nohales Llorente Carlos Ramon Duran-Merino Massimo Lazzeri Source Type: research

Clinical indications for necessary and discretionary hospital readmissions after radical cystectomy
Urol Oncol. 2021 Oct 7:S1078-1439(21)00413-0. doi: 10.1016/j.urolonc.2021.09.001. Online ahead of print.ABSTRACTBACKGROUND: To assess predictors, indicators and medical necessity of readmissions after neoadjuvant chemotherapy and radical cystectomy in order to identify opportunities for reducing readmission rates.METHODS: Records for patients treated with cisplatin-based neoadjuvant chemotherapy followed by radical cystectomy between 2007 and 2017 were reviewed for 90-day complications and readmission. Readmissions were classified as necessary vs. discretionary based on independent clinician review. The association between...
Source: Urologic Oncology - October 11, 2021 Category: Urology & Nephrology Authors: Ahmet Murat Aydin Richard R Reich Biwei Cao Salim K Cheriyan Ali Hajiran Logan Zemp Alice Yu Michael A Poch Wade J Sexton Roger Li Scott M Gilbert Source Type: research

Does neoadjuvant chemotherapy diminish the sex disparity in bladder cancer survival after radical cystectomy?
Urol Oncol. 2021 Oct 7:S1078-1439(21)00415-4. doi: 10.1016/j.urolonc.2021.09.003. Online ahead of print.ABSTRACTINTRODUCTION: Sex-specific survival disparities for bladder cancer outcomes after radical cystectomy (RC) have been demonstrated in several studies. However, these studies predate the widespread adoption of neoadjuvant chemotherapy (NAC). We evaluated the differences in sex-specific survival between patients who received NAC with those who did not, using a contemporary national outcomes database.METHODS: The National Cancer Data Base was queried from 2004 to 2015 to identify subjects who underwent RC. Kaplan-Meie...
Source: Urologic Oncology - October 11, 2021 Category: Urology & Nephrology Authors: Siv Venkat Aleem I Khan Benjamin L Taylor Neal A Patel Bashir Al Hussein Al Awamlh Lina Posada Calderon Jonathan Fainberg Jonathan Shoag Douglas S Scherr Source Type: research

Fighting the 'tobacco epidemic' - A call to action to identify Targeted Intervention Points (TIPs) for better counseling patients with urothelial cancer
Urol Oncol. 2021 Oct 7:S1078-1439(21)00407-5. doi: 10.1016/j.urolonc.2021.08.025. Online ahead of print.ABSTRACTThe association between tobacco use and urothelial cancer of the bladder is well known. Given the worsening tobacco epidemic, here we make the case for systematic targeted points of intervention for urologists and other professionals to intervene against bladder cancer. Awareness of contemporary checkpoints where we can intervene for counseling patients may help medical education in a tobacco-pandemic difficult setting.PMID:34629283 | DOI:10.1016/j.urolonc.2021.08.025 (Source: Urologic Oncology)
Source: Urologic Oncology - October 11, 2021 Category: Urology & Nephrology Authors: Giovanni E Cacciamani Richard S Matulewicz Raj Kumar Jeremy Yuen-Chun Teoh Andrea Mari Benjamin Pradere Juan Gomez Rivas Andrea Necchi Sumanta Kumar Pal Maria J Ribal Shahrokh Shariat Michael Rink SMART (Stop sMoking for Advance Rehabilitation Treatments) Source Type: research

Clinical indications for necessary and discretionary hospital readmissions after radical cystectomy
Urol Oncol. 2021 Oct 7:S1078-1439(21)00413-0. doi: 10.1016/j.urolonc.2021.09.001. Online ahead of print.ABSTRACTBACKGROUND: To assess predictors, indicators and medical necessity of readmissions after neoadjuvant chemotherapy and radical cystectomy in order to identify opportunities for reducing readmission rates.METHODS: Records for patients treated with cisplatin-based neoadjuvant chemotherapy followed by radical cystectomy between 2007 and 2017 were reviewed for 90-day complications and readmission. Readmissions were classified as necessary vs. discretionary based on independent clinician review. The association between...
Source: Urologic Oncology - October 11, 2021 Category: Urology & Nephrology Authors: Ahmet Murat Aydin Richard R Reich Biwei Cao Salim K Cheriyan Ali Hajiran Logan Zemp Alice Yu Michael A Poch Wade J Sexton Roger Li Scott M Gilbert Source Type: research

Does neoadjuvant chemotherapy diminish the sex disparity in bladder cancer survival after radical cystectomy?
Urol Oncol. 2021 Oct 7:S1078-1439(21)00415-4. doi: 10.1016/j.urolonc.2021.09.003. Online ahead of print.ABSTRACTINTRODUCTION: Sex-specific survival disparities for bladder cancer outcomes after radical cystectomy (RC) have been demonstrated in several studies. However, these studies predate the widespread adoption of neoadjuvant chemotherapy (NAC). We evaluated the differences in sex-specific survival between patients who received NAC with those who did not, using a contemporary national outcomes database.METHODS: The National Cancer Data Base was queried from 2004 to 2015 to identify subjects who underwent RC. Kaplan-Meie...
Source: Urologic Oncology - October 11, 2021 Category: Urology & Nephrology Authors: Siv Venkat Aleem I Khan Benjamin L Taylor Neal A Patel Bashir Al Hussein Al Awamlh Lina Posada Calderon Jonathan Fainberg Jonathan Shoag Douglas S Scherr Source Type: research

Fighting the 'tobacco epidemic' - A call to action to identify Targeted Intervention Points (TIPs) for better counseling patients with urothelial cancer
Urol Oncol. 2021 Oct 7:S1078-1439(21)00407-5. doi: 10.1016/j.urolonc.2021.08.025. Online ahead of print.ABSTRACTThe association between tobacco use and urothelial cancer of the bladder is well known. Given the worsening tobacco epidemic, here we make the case for systematic targeted points of intervention for urologists and other professionals to intervene against bladder cancer. Awareness of contemporary checkpoints where we can intervene for counseling patients may help medical education in a tobacco-pandemic difficult setting.PMID:34629283 | DOI:10.1016/j.urolonc.2021.08.025 (Source: Urologic Oncology)
Source: Urologic Oncology - October 11, 2021 Category: Urology & Nephrology Authors: Giovanni E Cacciamani Richard S Matulewicz Raj Kumar Jeremy Yuen-Chun Teoh Andrea Mari Benjamin Pradere Juan Gomez Rivas Andrea Necchi Sumanta Kumar Pal Maria J Ribal Shahrokh Shariat Michael Rink SMART (Stop sMoking for Advance Rehabilitation Treatments) Source Type: research

Clinical indications for necessary and discretionary hospital readmissions after radical cystectomy
Urol Oncol. 2021 Oct 7:S1078-1439(21)00413-0. doi: 10.1016/j.urolonc.2021.09.001. Online ahead of print.ABSTRACTBACKGROUND: To assess predictors, indicators and medical necessity of readmissions after neoadjuvant chemotherapy and radical cystectomy in order to identify opportunities for reducing readmission rates.METHODS: Records for patients treated with cisplatin-based neoadjuvant chemotherapy followed by radical cystectomy between 2007 and 2017 were reviewed for 90-day complications and readmission. Readmissions were classified as necessary vs. discretionary based on independent clinician review. The association between...
Source: Urologic Oncology - October 11, 2021 Category: Urology & Nephrology Authors: Ahmet Murat Aydin Richard R Reich Biwei Cao Salim K Cheriyan Ali Hajiran Logan Zemp Alice Yu Michael A Poch Wade J Sexton Roger Li Scott M Gilbert Source Type: research

Does neoadjuvant chemotherapy diminish the sex disparity in bladder cancer survival after radical cystectomy?
Urol Oncol. 2021 Oct 7:S1078-1439(21)00415-4. doi: 10.1016/j.urolonc.2021.09.003. Online ahead of print.ABSTRACTINTRODUCTION: Sex-specific survival disparities for bladder cancer outcomes after radical cystectomy (RC) have been demonstrated in several studies. However, these studies predate the widespread adoption of neoadjuvant chemotherapy (NAC). We evaluated the differences in sex-specific survival between patients who received NAC with those who did not, using a contemporary national outcomes database.METHODS: The National Cancer Data Base was queried from 2004 to 2015 to identify subjects who underwent RC. Kaplan-Meie...
Source: Urologic Oncology - October 11, 2021 Category: Urology & Nephrology Authors: Siv Venkat Aleem I Khan Benjamin L Taylor Neal A Patel Bashir Al Hussein Al Awamlh Lina Posada Calderon Jonathan Fainberg Jonathan Shoag Douglas S Scherr Source Type: research

Fighting the 'tobacco epidemic' - A call to action to identify Targeted Intervention Points (TIPs) for better counseling patients with urothelial cancer
Urol Oncol. 2021 Oct 7:S1078-1439(21)00407-5. doi: 10.1016/j.urolonc.2021.08.025. Online ahead of print.ABSTRACTThe association between tobacco use and urothelial cancer of the bladder is well known. Given the worsening tobacco epidemic, here we make the case for systematic targeted points of intervention for urologists and other professionals to intervene against bladder cancer. Awareness of contemporary checkpoints where we can intervene for counseling patients may help medical education in a tobacco-pandemic difficult setting.PMID:34629283 | DOI:10.1016/j.urolonc.2021.08.025 (Source: Urologic Oncology)
Source: Urologic Oncology - October 11, 2021 Category: Urology & Nephrology Authors: Giovanni E Cacciamani Richard S Matulewicz Raj Kumar Jeremy Yuen-Chun Teoh Andrea Mari Benjamin Pradere Juan Gomez Rivas Andrea Necchi Sumanta Kumar Pal Maria J Ribal Shahrokh Shariat Michael Rink SMART (Stop sMoking for Advance Rehabilitation Treatments) Source Type: research

Clinical indications for necessary and discretionary hospital readmissions after radical cystectomy
Urol Oncol. 2021 Oct 7:S1078-1439(21)00413-0. doi: 10.1016/j.urolonc.2021.09.001. Online ahead of print.ABSTRACTBACKGROUND: To assess predictors, indicators and medical necessity of readmissions after neoadjuvant chemotherapy and radical cystectomy in order to identify opportunities for reducing readmission rates.METHODS: Records for patients treated with cisplatin-based neoadjuvant chemotherapy followed by radical cystectomy between 2007 and 2017 were reviewed for 90-day complications and readmission. Readmissions were classified as necessary vs. discretionary based on independent clinician review. The association between...
Source: Urologic Oncology - October 11, 2021 Category: Urology & Nephrology Authors: Ahmet Murat Aydin Richard R Reich Biwei Cao Salim K Cheriyan Ali Hajiran Logan Zemp Alice Yu Michael A Poch Wade J Sexton Roger Li Scott M Gilbert Source Type: research

Does neoadjuvant chemotherapy diminish the sex disparity in bladder cancer survival after radical cystectomy?
Urol Oncol. 2021 Oct 7:S1078-1439(21)00415-4. doi: 10.1016/j.urolonc.2021.09.003. Online ahead of print.ABSTRACTINTRODUCTION: Sex-specific survival disparities for bladder cancer outcomes after radical cystectomy (RC) have been demonstrated in several studies. However, these studies predate the widespread adoption of neoadjuvant chemotherapy (NAC). We evaluated the differences in sex-specific survival between patients who received NAC with those who did not, using a contemporary national outcomes database.METHODS: The National Cancer Data Base was queried from 2004 to 2015 to identify subjects who underwent RC. Kaplan-Meie...
Source: Urologic Oncology - October 11, 2021 Category: Urology & Nephrology Authors: Siv Venkat Aleem I Khan Benjamin L Taylor Neal A Patel Bashir Al Hussein Al Awamlh Lina Posada Calderon Jonathan Fainberg Jonathan Shoag Douglas S Scherr Source Type: research

Fighting the 'tobacco epidemic' - A call to action to identify Targeted Intervention Points (TIPs) for better counseling patients with urothelial cancer
Urol Oncol. 2021 Oct 7:S1078-1439(21)00407-5. doi: 10.1016/j.urolonc.2021.08.025. Online ahead of print.ABSTRACTThe association between tobacco use and urothelial cancer of the bladder is well known. Given the worsening tobacco epidemic, here we make the case for systematic targeted points of intervention for urologists and other professionals to intervene against bladder cancer. Awareness of contemporary checkpoints where we can intervene for counseling patients may help medical education in a tobacco-pandemic difficult setting.PMID:34629283 | DOI:10.1016/j.urolonc.2021.08.025 (Source: Urologic Oncology)
Source: Urologic Oncology - October 11, 2021 Category: Urology & Nephrology Authors: Giovanni E Cacciamani Richard S Matulewicz Raj Kumar Jeremy Yuen-Chun Teoh Andrea Mari Benjamin Pradere Juan Gomez Rivas Andrea Necchi Sumanta Kumar Pal Maria J Ribal Shahrokh Shariat Michael Rink SMART (Stop sMoking for Advance Rehabilitation Treatments) Source Type: research

Development and validation of a nomogram to predict postoperative cancer-specific survival of patients with nonmetastatic T3a renal cell carcinoma
Urol Oncol. 2021 Oct 4:S1078-1439(21)00273-8. doi: 10.1016/j.urolonc.2021.06.014. Online ahead of print.ABSTRACTPURPOSE: To establish a nomogram for the prediction of postoperative cancer-specific survival (CSS) in patients with nonmetastatic T3a renal cell carcinoma (RCC).METHODS: The Surveillance, Epidemiology, and End Results database were searched for patients with pT3aN0-1M0 RCC between 2010 and 2018. The patients were randomly stratified into the training and verification group (7:3 ratio). Using Cox regression analysis, the predictors for the CSS in the training group were integrated to establish the nomogram for pr...
Source: Urologic Oncology - October 8, 2021 Category: Urology & Nephrology Authors: Pengju Guo Yongxing Wang Yili Han Dechao Wei Jiahui Zhao Mingchuan Li Yongguang Jiang Yong Luo Source Type: research

Development and validation of a nomogram to predict postoperative cancer-specific survival of patients with nonmetastatic T3a renal cell carcinoma
Urol Oncol. 2021 Oct 4:S1078-1439(21)00273-8. doi: 10.1016/j.urolonc.2021.06.014. Online ahead of print.ABSTRACTPURPOSE: To establish a nomogram for the prediction of postoperative cancer-specific survival (CSS) in patients with nonmetastatic T3a renal cell carcinoma (RCC).METHODS: The Surveillance, Epidemiology, and End Results database were searched for patients with pT3aN0-1M0 RCC between 2010 and 2018. The patients were randomly stratified into the training and verification group (7:3 ratio). Using Cox regression analysis, the predictors for the CSS in the training group were integrated to establish the nomogram for pr...
Source: Urologic Oncology - October 8, 2021 Category: Urology & Nephrology Authors: Pengju Guo Yongxing Wang Yili Han Dechao Wei Jiahui Zhao Mingchuan Li Yongguang Jiang Yong Luo Source Type: research

Development and validation of a nomogram to predict postoperative cancer-specific survival of patients with nonmetastatic T3a renal cell carcinoma
Urol Oncol. 2021 Oct 4:S1078-1439(21)00273-8. doi: 10.1016/j.urolonc.2021.06.014. Online ahead of print.ABSTRACTPURPOSE: To establish a nomogram for the prediction of postoperative cancer-specific survival (CSS) in patients with nonmetastatic T3a renal cell carcinoma (RCC).METHODS: The Surveillance, Epidemiology, and End Results database were searched for patients with pT3aN0-1M0 RCC between 2010 and 2018. The patients were randomly stratified into the training and verification group (7:3 ratio). Using Cox regression analysis, the predictors for the CSS in the training group were integrated to establish the nomogram for pr...
Source: Urologic Oncology - October 8, 2021 Category: Urology & Nephrology Authors: Pengju Guo Yongxing Wang Yili Han Dechao Wei Jiahui Zhao Mingchuan Li Yongguang Jiang Yong Luo Source Type: research

Should men undergo MRI before prostate biopsy - CON
Urol Oncol. 2021 Sep 30:S1078-1439(21)00365-3. doi: 10.1016/j.urolonc.2021.08.006. Online ahead of print.ABSTRACTProstate magnetic resonance imaging (MRI) is increasingly used prior to biopsy in response to the overdiagnosis and overtreatment of prostate cancer (CaP) associated with prostate-specific antigen (PSA) based screening. However, technical limitations in the conventional diffusion-weighted imaging (DWI) sequences as well as the high degree of radiologist-to-radiologist variability in interpreting prostate MRI result in inadequate accuracy. Specifically, the insufficient negative predictive value (NPV) of prostate...
Source: Urologic Oncology - October 4, 2021 Category: Urology & Nephrology Authors: Eric H Kim Gerald L Andriole Source Type: research

Robotic-assisted radical cystectomy is associated with lower perioperative mortality in octogenarians
CONCLUSION: RARC is safe and feasible in octogenarians. Elderly patients may derive more benefit from minimally invasive radical cystectomy compared to a younger cohort.PMID:34602361 | DOI:10.1016/j.urolonc.2021.08.027 (Source: Urologic Oncology)
Source: Urologic Oncology - October 4, 2021 Category: Urology & Nephrology Authors: Alice Yu Ye Wang Matthew Mossanen Mark Preston Filipe Lf Carvalho Benjamin I Chung Steven L Chang Source Type: research

Risk factors and survival outcomes for upstaging after inguinal lymph node dissection for cN1 penile squamous cell carcinoma
Urol Oncol. 2021 Sep 30:S1078-1439(21)00411-7. doi: 10.1016/j.urolonc.2021.08.028. Online ahead of print.ABSTRACTOBJECTIVES: To identify incidence and risk factors for upstaging from cN1 to pN2/N3 at inguinal lymphadenectomy (ILND) for penile cancer (pSCC). Our secondary objective is to assess survival outcomes and associations for cN1 patients undergoing ILND.SUBJECTS/PATIENTS AND METHODS: Patients with pT≥1cN1cM0 pSCC who underwent bilateral ILND and had complete data were identified in a multi-institutional international cohort from 8 referral centers in 7 countries diagnosed from 1980 to 2017. Upstaging was defined ...
Source: Urologic Oncology - October 4, 2021 Category: Urology & Nephrology Authors: Nicholas H Chakiryan Aaron Dahmen Marco Bandini Filippo Pederzoli Laura Marandino Maarten Albersen Eduard Roussel Yao Zhu Ding-Wei Ye Antonio A Ornellas Mario Catanzaro Oliver W Hakenberg Axel Heidenreich Friederike Haidl Nick Watkin Michael Ager Alberto Source Type: research

Should men undergo MRI before prostate biopsy - CON
Urol Oncol. 2021 Sep 30:S1078-1439(21)00365-3. doi: 10.1016/j.urolonc.2021.08.006. Online ahead of print.ABSTRACTProstate magnetic resonance imaging (MRI) is increasingly used prior to biopsy in response to the overdiagnosis and overtreatment of prostate cancer (CaP) associated with prostate-specific antigen (PSA) based screening. However, technical limitations in the conventional diffusion-weighted imaging (DWI) sequences as well as the high degree of radiologist-to-radiologist variability in interpreting prostate MRI result in inadequate accuracy. Specifically, the insufficient negative predictive value (NPV) of prostate...
Source: Urologic Oncology - October 4, 2021 Category: Urology & Nephrology Authors: Eric H Kim Gerald L Andriole Source Type: research

Robotic-assisted radical cystectomy is associated with lower perioperative mortality in octogenarians
CONCLUSION: RARC is safe and feasible in octogenarians. Elderly patients may derive more benefit from minimally invasive radical cystectomy compared to a younger cohort.PMID:34602361 | DOI:10.1016/j.urolonc.2021.08.027 (Source: Urologic Oncology)
Source: Urologic Oncology - October 4, 2021 Category: Urology & Nephrology Authors: Alice Yu Ye Wang Matthew Mossanen Mark Preston Filipe Lf Carvalho Benjamin I Chung Steven L Chang Source Type: research

Risk factors and survival outcomes for upstaging after inguinal lymph node dissection for cN1 penile squamous cell carcinoma
Urol Oncol. 2021 Sep 30:S1078-1439(21)00411-7. doi: 10.1016/j.urolonc.2021.08.028. Online ahead of print.ABSTRACTOBJECTIVES: To identify incidence and risk factors for upstaging from cN1 to pN2/N3 at inguinal lymphadenectomy (ILND) for penile cancer (pSCC). Our secondary objective is to assess survival outcomes and associations for cN1 patients undergoing ILND.SUBJECTS/PATIENTS AND METHODS: Patients with pT≥1cN1cM0 pSCC who underwent bilateral ILND and had complete data were identified in a multi-institutional international cohort from 8 referral centers in 7 countries diagnosed from 1980 to 2017. Upstaging was defined ...
Source: Urologic Oncology - October 4, 2021 Category: Urology & Nephrology Authors: Nicholas H Chakiryan Aaron Dahmen Marco Bandini Filippo Pederzoli Laura Marandino Maarten Albersen Eduard Roussel Yao Zhu Ding-Wei Ye Antonio A Ornellas Mario Catanzaro Oliver W Hakenberg Axel Heidenreich Friederike Haidl Nick Watkin Michael Ager Alberto Source Type: research

Should men undergo MRI before prostate biopsy - CON
Urol Oncol. 2021 Sep 30:S1078-1439(21)00365-3. doi: 10.1016/j.urolonc.2021.08.006. Online ahead of print.ABSTRACTProstate magnetic resonance imaging (MRI) is increasingly used prior to biopsy in response to the overdiagnosis and overtreatment of prostate cancer (CaP) associated with prostate-specific antigen (PSA) based screening. However, technical limitations in the conventional diffusion-weighted imaging (DWI) sequences as well as the high degree of radiologist-to-radiologist variability in interpreting prostate MRI result in inadequate accuracy. Specifically, the insufficient negative predictive value (NPV) of prostate...
Source: Urologic Oncology - October 4, 2021 Category: Urology & Nephrology Authors: Eric H Kim Gerald L Andriole Source Type: research

Robotic-assisted radical cystectomy is associated with lower perioperative mortality in octogenarians
CONCLUSION: RARC is safe and feasible in octogenarians. Elderly patients may derive more benefit from minimally invasive radical cystectomy compared to a younger cohort.PMID:34602361 | DOI:10.1016/j.urolonc.2021.08.027 (Source: Urologic Oncology)
Source: Urologic Oncology - October 4, 2021 Category: Urology & Nephrology Authors: Alice Yu Ye Wang Matthew Mossanen Mark Preston Filipe Lf Carvalho Benjamin I Chung Steven L Chang Source Type: research

Risk factors and survival outcomes for upstaging after inguinal lymph node dissection for cN1 penile squamous cell carcinoma
Urol Oncol. 2021 Sep 30:S1078-1439(21)00411-7. doi: 10.1016/j.urolonc.2021.08.028. Online ahead of print.ABSTRACTOBJECTIVES: To identify incidence and risk factors for upstaging from cN1 to pN2/N3 at inguinal lymphadenectomy (ILND) for penile cancer (pSCC). Our secondary objective is to assess survival outcomes and associations for cN1 patients undergoing ILND.SUBJECTS/PATIENTS AND METHODS: Patients with pT≥1cN1cM0 pSCC who underwent bilateral ILND and had complete data were identified in a multi-institutional international cohort from 8 referral centers in 7 countries diagnosed from 1980 to 2017. Upstaging was defined ...
Source: Urologic Oncology - October 4, 2021 Category: Urology & Nephrology Authors: Nicholas H Chakiryan Aaron Dahmen Marco Bandini Filippo Pederzoli Laura Marandino Maarten Albersen Eduard Roussel Yao Zhu Ding-Wei Ye Antonio A Ornellas Mario Catanzaro Oliver W Hakenberg Axel Heidenreich Friederike Haidl Nick Watkin Michael Ager Alberto Source Type: research

Should men undergo MRI before prostate biopsy - CON
Urol Oncol. 2021 Sep 30:S1078-1439(21)00365-3. doi: 10.1016/j.urolonc.2021.08.006. Online ahead of print.ABSTRACTProstate magnetic resonance imaging (MRI) is increasingly used prior to biopsy in response to the overdiagnosis and overtreatment of prostate cancer (CaP) associated with prostate-specific antigen (PSA) based screening. However, technical limitations in the conventional diffusion-weighted imaging (DWI) sequences as well as the high degree of radiologist-to-radiologist variability in interpreting prostate MRI result in inadequate accuracy. Specifically, the insufficient negative predictive value (NPV) of prostate...
Source: Urologic Oncology - October 4, 2021 Category: Urology & Nephrology Authors: Eric H Kim Gerald L Andriole Source Type: research

Robotic-assisted radical cystectomy is associated with lower perioperative mortality in octogenarians
CONCLUSION: RARC is safe and feasible in octogenarians. Elderly patients may derive more benefit from minimally invasive radical cystectomy compared to a younger cohort.PMID:34602361 | DOI:10.1016/j.urolonc.2021.08.027 (Source: Urologic Oncology)
Source: Urologic Oncology - October 4, 2021 Category: Urology & Nephrology Authors: Alice Yu Ye Wang Matthew Mossanen Mark Preston Filipe Lf Carvalho Benjamin I Chung Steven L Chang Source Type: research

Risk factors and survival outcomes for upstaging after inguinal lymph node dissection for cN1 penile squamous cell carcinoma
Urol Oncol. 2021 Sep 30:S1078-1439(21)00411-7. doi: 10.1016/j.urolonc.2021.08.028. Online ahead of print.ABSTRACTOBJECTIVES: To identify incidence and risk factors for upstaging from cN1 to pN2/N3 at inguinal lymphadenectomy (ILND) for penile cancer (pSCC). Our secondary objective is to assess survival outcomes and associations for cN1 patients undergoing ILND.SUBJECTS/PATIENTS AND METHODS: Patients with pT≥1cN1cM0 pSCC who underwent bilateral ILND and had complete data were identified in a multi-institutional international cohort from 8 referral centers in 7 countries diagnosed from 1980 to 2017. Upstaging was defined ...
Source: Urologic Oncology - October 4, 2021 Category: Urology & Nephrology Authors: Nicholas H Chakiryan Aaron Dahmen Marco Bandini Filippo Pederzoli Laura Marandino Maarten Albersen Eduard Roussel Yao Zhu Ding-Wei Ye Antonio A Ornellas Mario Catanzaro Oliver W Hakenberg Axel Heidenreich Friederike Haidl Nick Watkin Michael Ager Alberto Source Type: research

Poor clinical outcomes and immunoevasive contexture in SIRP ╬▒ < sup > + < /sup > tumor-associated macrophages enriched muscle-invasive bladder cancer patients
CONCLUSIONS: SIRPα+ TAMs infiltration indicated poor prognosis and ACT resistance in MIBC. Immunosuppressive SIRPα+ TAMs is closely related to immune evasion with exhausted T cells states, suggesting the prospect of SIRPα+ TAMs as a potential therapeutic target in MIBC.PMID:34600802 | DOI:10.1016/j.urolonc.2021.08.024 (Source: Urologic Oncology)
Source: Urologic Oncology - October 3, 2021 Category: Urology & Nephrology Authors: Ziang Xu Han Zeng Zhaopei Liu Kaifeng Jin Yuan Chang Yiwei Wang Li Liu Yu Zhu Le Xu Zewei Wang Jianming Guo Jiejie Xu Source Type: research

Out-of-pocket costs for commercially insured patients with localized prostate cancer
Urol Oncol. 2021 Sep 30:S1078-1439(21)00409-9. doi: 10.1016/j.urolonc.2021.08.026. Online ahead of print.ABSTRACTPURPOSE: Financial toxicity is an underappreciated component of cancer survivorship. Treatment-specific out-of-pocket costs for patients undergoing localized prostate cancer treatment have not, to date, been described and may influence patient's decision making.METHODS: We performed a retrospective cohort study among commercially-insured patients in the United States with incident prostate cancer from 2013 to 2018. We captured out-of-pocket and total costs in the year following diagnosis and compared these betwe...
Source: Urologic Oncology - October 3, 2021 Category: Urology & Nephrology Authors: Christopher J D Wallis Daniel D Joyce Zachary Klaassen Amy N Luckenbaugh Aaron A Laviana David Penson Stacie B Dusetzina Daniel A Barocas Source Type: research

Somatic mutations as preoperative predictors of metastases in patients with localized clear cell renal cell carcinoma - An exploratory analysis
CONCLUSION: In the current exploratory analysis, SETD2 mutations were significant predictors of MFP among patients treated for localized ccRCC. Our findings support future studies evaluating genetic alterations in preoperative renal biopsy samples as potential predictors of treatment outcome.PMID:34580025 | DOI:10.1016/j.urolonc.2021.08.018 (Source: Urologic Oncology)
Source: Urologic Oncology - September 28, 2021 Category: Urology & Nephrology Authors: Roy Mano Cihan Duzgol Maz Ganat Debra A Goldman Kyle A Blum Andrew W Silagy Aleksandra Walasek Alejandro Sanchez Renzo G DiNatale Julian Marcon Mahyar Kashan Maria F Becerra Nicole E Benfante Jonathan A Coleman Michael W Kattan Paul Russo Oguz Akin Irina Source Type: research

Evaluation of the association of health care system access with kidney cancer surgical outcomes for hispanic and non-hispanic white patients
CONCLUSIONS: Hispanics had lower all-cause mortality risk and no significant differences in 5-year overall survival and CSS compared to non-Hispanic Whites. Our findings indicate that tertiary referral centers may help mitigate inequalities in access to care.PMID:34580026 | DOI:10.1016/j.urolonc.2021.08.021 (Source: Urologic Oncology)
Source: Urologic Oncology - September 28, 2021 Category: Urology & Nephrology Authors: Juan F Javier-DesLoges Margaret F Meagher Arman Walia Mimi V Nguyen John M Perry Rekha S Narasimhan Kevin Hakimi Shady Soliman Julia Yuan Madison A Chakoumakos Fady Ghali Devin N Patel Fang Wan James D Murphy Ithaar H Derweesh Source Type: research

Clinical laboratory tests associated with survival in patients with metastatic renal cell carcinoma: A Laboratory Wide Association Study (LWAS)
CONCLUSIONS: Routinely measured laboratory tests can refine current prognostic models, facilitate comparisons across clinical trial cohorts, and match patients with specific systemic therapies.PMID:34580027 | DOI:10.1016/j.urolonc.2021.08.011 (Source: Urologic Oncology)
Source: Urologic Oncology - September 28, 2021 Category: Urology & Nephrology Authors: Kyla Velaer I-Chun Thomas Jaden Yang Kristopher Kapphahn Thomas J Metzner Abhinav Golla Christian R Hoerner Alice C Fan Viraj Master Glenn M Chertow James D Brooks Chirag J Patel Manisha Desai John T Leppert Source Type: research