The relationship between BCG immunotherapy and oxidative stress parameters in patients with nonmuscle invasive bladder cancer
CONCLUSION: The findings suggest that the carcinogenesis of NMIBC is associated with oxidative damage of biomolecules and indicates the involvement of oxidative stress markers in the development and recurrence of NMIBC.; Therefore, it is critical to ensure the management for T1 high grade and tumor size of >2.5 cm for antioxidant protection.PMID:37932135 | DOI:10.1016/j.urolonc.2023.09.008 (Source: Urologic Oncology)
Source: Urologic Oncology - November 6, 2023 Category: Urology & Nephrology Authors: Vishwajeet Singh Mukul Kumar Singh Mayank Jain Anuj Kumar Pandey Anil Kumar Dinesh Kumar Sahu Source Type: research
The relationship between BCG immunotherapy and oxidative stress parameters in patients with nonmuscle invasive bladder cancer
CONCLUSION: The findings suggest that the carcinogenesis of NMIBC is associated with oxidative damage of biomolecules and indicates the involvement of oxidative stress markers in the development and recurrence of NMIBC.; Therefore, it is critical to ensure the management for T1 high grade and tumor size of >2.5 cm for antioxidant protection.PMID:37932135 | DOI:10.1016/j.urolonc.2023.09.008 (Source: Urologic Oncology)
Source: Urologic Oncology - November 6, 2023 Category: Urology & Nephrology Authors: Vishwajeet Singh Mukul Kumar Singh Mayank Jain Anuj Kumar Pandey Anil Kumar Dinesh Kumar Sahu Source Type: research
A retrospective cohort study of the impact of peripheral blood gamma- delta T cells to prognosis of nonmetastatic renal cell cancer after curative resection
CONCLUSION: A low proportion of γδT cells was identified as one of the risk factors for RFS. Our findings will provide clues to develop strategies for early intervention in preventing recurrence even after complete resection of RCC and, such as adoptive immunotherapy using autologous γδT cells in patients with a low proportion of γδT cells.PMID:37919100 | DOI:10.1016/j.urolonc.2023.10.001 (Source: Urologic Oncology)
Source: Urologic Oncology - November 2, 2023 Category: Urology & Nephrology Authors: Hirohito Kobayashi Tsunenori Kondo Junpei Iizuka Kazuhiko Yoshida Toshio Takagi Source Type: research
A retrospective cohort study of the impact of peripheral blood gamma- delta T cells to prognosis of nonmetastatic renal cell cancer after curative resection
CONCLUSION: A low proportion of γδT cells was identified as one of the risk factors for RFS. Our findings will provide clues to develop strategies for early intervention in preventing recurrence even after complete resection of RCC and, such as adoptive immunotherapy using autologous γδT cells in patients with a low proportion of γδT cells.PMID:37919100 | DOI:10.1016/j.urolonc.2023.10.001 (Source: Urologic Oncology)
Source: Urologic Oncology - November 2, 2023 Category: Urology & Nephrology Authors: Hirohito Kobayashi Tsunenori Kondo Junpei Iizuka Kazuhiko Yoshida Toshio Takagi Source Type: research
A retrospective cohort study of the impact of peripheral blood gamma- delta T cells to prognosis of nonmetastatic renal cell cancer after curative resection
CONCLUSION: A low proportion of γδT cells was identified as one of the risk factors for RFS. Our findings will provide clues to develop strategies for early intervention in preventing recurrence even after complete resection of RCC and, such as adoptive immunotherapy using autologous γδT cells in patients with a low proportion of γδT cells.PMID:37919100 | DOI:10.1016/j.urolonc.2023.10.001 (Source: Urologic Oncology)
Source: Urologic Oncology - November 2, 2023 Category: Urology & Nephrology Authors: Hirohito Kobayashi Tsunenori Kondo Junpei Iizuka Kazuhiko Yoshida Toshio Takagi Source Type: research
A retrospective cohort study of the impact of peripheral blood gamma- delta T cells to prognosis of nonmetastatic renal cell cancer after curative resection
CONCLUSION: A low proportion of γδT cells was identified as one of the risk factors for RFS. Our findings will provide clues to develop strategies for early intervention in preventing recurrence even after complete resection of RCC and, such as adoptive immunotherapy using autologous γδT cells in patients with a low proportion of γδT cells.PMID:37919100 | DOI:10.1016/j.urolonc.2023.10.001 (Source: Urologic Oncology)
Source: Urologic Oncology - November 2, 2023 Category: Urology & Nephrology Authors: Hirohito Kobayashi Tsunenori Kondo Junpei Iizuka Kazuhiko Yoshida Toshio Takagi Source Type: research
Extracellular vesicle biomarkers for prostate cancer diagnosis: A systematic review and meta-analysis
Urol Oncol. 2023 Oct 30:S1078-1439(23)00295-8. doi: 10.1016/j.urolonc.2023.08.019. Online ahead of print.ABSTRACTExtracellular vesicle (EV) biomarkers have promising diagnostic and screening capabilities for several cancers, and growing evidence indicates that EV biomarkers can be used as diagnostic markers for prostate cancer (CaP). However, data on the diagnostic accuracy of EV biomarkers for CaP diagnosis are conflicting. We performed a systematic review and meta-analysis, aimed to summarize the diagnostic performance of EV biomarkers for CaP. We systematically searched PubMed, Medline, and Web of Science from inception...
Source: Urologic Oncology - November 1, 2023 Category: Urology & Nephrology Authors: Yang Li Xianquan Shi Erna Jia Shaoyou Qin Fan Yu Source Type: research
Extracellular vesicle biomarkers for prostate cancer diagnosis: A systematic review and meta-analysis
Urol Oncol. 2023 Oct 30:S1078-1439(23)00295-8. doi: 10.1016/j.urolonc.2023.08.019. Online ahead of print.ABSTRACTExtracellular vesicle (EV) biomarkers have promising diagnostic and screening capabilities for several cancers, and growing evidence indicates that EV biomarkers can be used as diagnostic markers for prostate cancer (CaP). However, data on the diagnostic accuracy of EV biomarkers for CaP diagnosis are conflicting. We performed a systematic review and meta-analysis, aimed to summarize the diagnostic performance of EV biomarkers for CaP. We systematically searched PubMed, Medline, and Web of Science from inception...
Source: Urologic Oncology - November 1, 2023 Category: Urology & Nephrology Authors: Yang Li Xianquan Shi Erna Jia Shaoyou Qin Fan Yu Source Type: research
Primary squamous cell carcinoma of the scrotum: Outcomes from a specialist center
CONCLUSION: Scrotal SCC is extremely rare in the UK with only 10 primary cases identified in our center over the past 10 years. Surgical resection of the tumor and appropriate inguinal node staging are required due to a high proportion of cases which metastasize to the inguinal lymph nodes.PATIENT SUMMARY: Scrotal cancer is rare. 10 cases were diagnosed over 10 years at a single center. Around half had disease spread to the groin nodes or distant organs at presentation. Surgical resection was required in all patients. At the time of analysis, half of the patients are alive. Due to the rarity and aggressiveness of the cance...
Source: Urologic Oncology - October 30, 2023 Category: Urology & Nephrology Authors: Karl H Pang Giuseppe Fallara Stanley Tang Aiman Haider Alex Freeman Paul Hadway Raj Nigam Rowland Rees Anita Mitra Costi Alifrangis Chris Bunker Hussain M Alnajjar Asif Muneer Source Type: research
Primary squamous cell carcinoma of the scrotum: Outcomes from a specialist center
CONCLUSION: Scrotal SCC is extremely rare in the UK with only 10 primary cases identified in our center over the past 10 years. Surgical resection of the tumor and appropriate inguinal node staging are required due to a high proportion of cases which metastasize to the inguinal lymph nodes.PATIENT SUMMARY: Scrotal cancer is rare. 10 cases were diagnosed over 10 years at a single center. Around half had disease spread to the groin nodes or distant organs at presentation. Surgical resection was required in all patients. At the time of analysis, half of the patients are alive. Due to the rarity and aggressiveness of the cance...
Source: Urologic Oncology - October 30, 2023 Category: Urology & Nephrology Authors: Karl H Pang Giuseppe Fallara Stanley Tang Aiman Haider Alex Freeman Paul Hadway Raj Nigam Rowland Rees Anita Mitra Costi Alifrangis Chris Bunker Hussain M Alnajjar Asif Muneer Source Type: research
Effectiveness of perioperative chemotherapy and radical cystectomy in treating bladder cancer
CONCLUSIONS: We report real-world outcomes from a large cohort of muscle-invasive bladder cancer patients undergoing surgical treatment with/out perioperative chemotherapy. Pathologic response rates to pre-surgical chemotherapy were modest and led to clinical benefit only in cT2 patients. Adjuvant chemotherapy provided survival benefit for pathologically advanced MIBC patients irrespective of pT/N staging.PMID:37880002 | DOI:10.1016/j.urolonc.2023.09.017 (Source: Urologic Oncology)
Source: Urologic Oncology - October 25, 2023 Category: Urology & Nephrology Authors: Roger Li Shreyas Naidu Wenyi Fan Kyle Rose Heather Huelster George Daniel Grass Aram Vosoughi Jasreman Dhillon Youngchul Kim Shilpa Gupta Rohit K Jain Jingsong Zhang Logan Zemp Alice Yu Michael A Poch Philippe E Spiess Julio Pow-Sang Scott M Gilbert Wade Source Type: research
Development of a novel score (RENSAFE) to determine probability of acute kidney injury and renal functional decline post surgery: A multicenter analysis
CONCLUSION: RENSAFE models utilizing perioperative variables that can predict AKI and CKD may help guide shared decision making. Impact of postsurgical AKI was limited to less severe CKD (eGFR<60 ml/min 71.73m2). Confirmatory studies are requisite.PMID:37880003 | DOI:10.1016/j.urolonc.2023.09.015 (Source: Urologic Oncology)
Source: Urologic Oncology - October 25, 2023 Category: Urology & Nephrology Authors: Cesare Saitta Jonathan A Afari Riccardo Autorino Umberto Capitanio Francesco Porpiglia Daniele Amparore Federico Piramide Clara Cerrato Margaret F Meagher Sabrina L Noyes Savio D Pandolfo Nicol ò M Buffi Alessandro Larcher Kevin Hakimi Mimi V Nguyen Dhru Source Type: research
Effectiveness of perioperative chemotherapy and radical cystectomy in treating bladder cancer
CONCLUSIONS: We report real-world outcomes from a large cohort of muscle-invasive bladder cancer patients undergoing surgical treatment with/out perioperative chemotherapy. Pathologic response rates to pre-surgical chemotherapy were modest and led to clinical benefit only in cT2 patients. Adjuvant chemotherapy provided survival benefit for pathologically advanced MIBC patients irrespective of pT/N staging.PMID:37880002 | DOI:10.1016/j.urolonc.2023.09.017 (Source: Urologic Oncology)
Source: Urologic Oncology - October 25, 2023 Category: Urology & Nephrology Authors: Roger Li Shreyas Naidu Wenyi Fan Kyle Rose Heather Huelster George Daniel Grass Aram Vosoughi Jasreman Dhillon Youngchul Kim Shilpa Gupta Rohit K Jain Jingsong Zhang Logan Zemp Alice Yu Michael A Poch Philippe E Spiess Julio Pow-Sang Scott M Gilbert Wade Source Type: research
Development of a novel score (RENSAFE) to determine probability of acute kidney injury and renal functional decline post surgery: A multicenter analysis
CONCLUSION: RENSAFE models utilizing perioperative variables that can predict AKI and CKD may help guide shared decision making. Impact of postsurgical AKI was limited to less severe CKD (eGFR<60 ml/min 71.73m2). Confirmatory studies are requisite.PMID:37880003 | DOI:10.1016/j.urolonc.2023.09.015 (Source: Urologic Oncology)
Source: Urologic Oncology - October 25, 2023 Category: Urology & Nephrology Authors: Cesare Saitta Jonathan A Afari Riccardo Autorino Umberto Capitanio Francesco Porpiglia Daniele Amparore Federico Piramide Clara Cerrato Margaret F Meagher Sabrina L Noyes Savio D Pandolfo Nicol ò M Buffi Alessandro Larcher Kevin Hakimi Mimi V Nguyen Dhru Source Type: research
Effectiveness of perioperative chemotherapy and radical cystectomy in treating bladder cancer
CONCLUSIONS: We report real-world outcomes from a large cohort of muscle-invasive bladder cancer patients undergoing surgical treatment with/out perioperative chemotherapy. Pathologic response rates to pre-surgical chemotherapy were modest and led to clinical benefit only in cT2 patients. Adjuvant chemotherapy provided survival benefit for pathologically advanced MIBC patients irrespective of pT/N staging.PMID:37880002 | DOI:10.1016/j.urolonc.2023.09.017 (Source: Urologic Oncology)
Source: Urologic Oncology - October 25, 2023 Category: Urology & Nephrology Authors: Roger Li Shreyas Naidu Wenyi Fan Kyle Rose Heather Huelster George Daniel Grass Aram Vosoughi Jasreman Dhillon Youngchul Kim Shilpa Gupta Rohit K Jain Jingsong Zhang Logan Zemp Alice Yu Michael A Poch Philippe E Spiess Julio Pow-Sang Scott M Gilbert Wade Source Type: research
