The prognostic role of histomorphological subtyping in nonmetastatic papillary renal cell carcinoma after curative surgery: is subtype really irrelevant? A propensity score matching analysis of a multi-institutional real life data
CONCLUSIONS: This multiinstitutional study suggested that type 2 was associated with adverse histopathologic outcomes, and predictor of RFS and CSS after surgical treatment of nonmetastatic papRCC, in overall cohort. In propensity score-matching cohort, type 2 remained the predictor of RFS. Eventhough 5th WHO classification for renal tumors eliminated histomorphological subtyping, these findings suggest that subtyping is relevant from the point of prognostic view.PMID:38443238 | DOI:10.1016/j.urolonc.2024.01.028 (Source: Urologic Oncology)
Source: Urologic Oncology - March 5, 2024 Category: Urology & Nephrology Authors: Selcuk Erdem Riccardo Bertolo Riccardo Campi Umberto Capitanio Daniele Amparore Umberto Anceschi Maria Carme Mir Eduard Roussel Nicola Pavan Umberto Carbonara Onder Kara Tobias Klatte Michele Marchioni Angela Pecoraro Stijn Muselaers Laura Marandino Pietr Source Type: research
The prognostic role of histomorphological subtyping in nonmetastatic papillary renal cell carcinoma after curative surgery: is subtype really irrelevant? A propensity score matching analysis of a multi-institutional real life data
CONCLUSIONS: This multiinstitutional study suggested that type 2 was associated with adverse histopathologic outcomes, and predictor of RFS and CSS after surgical treatment of nonmetastatic papRCC, in overall cohort. In propensity score-matching cohort, type 2 remained the predictor of RFS. Eventhough 5th WHO classification for renal tumors eliminated histomorphological subtyping, these findings suggest that subtyping is relevant from the point of prognostic view.PMID:38443238 | DOI:10.1016/j.urolonc.2024.01.028 (Source: Urologic Oncology)
Source: Urologic Oncology - March 5, 2024 Category: Urology & Nephrology Authors: Selcuk Erdem Riccardo Bertolo Riccardo Campi Umberto Capitanio Daniele Amparore Umberto Anceschi Maria Carme Mir Eduard Roussel Nicola Pavan Umberto Carbonara Onder Kara Tobias Klatte Michele Marchioni Angela Pecoraro Stijn Muselaers Laura Marandino Pietr Source Type: research
Comparative analysis of prognosis and gene expression in prostate cancer patients with site-specific visceral metastases
CONCLUSION: Patients diagnosed with mPCa and presenting with liver and/or lung metastases exhibit poorer prognoses. SCGB3A1, identified as a tumor suppressor gene, may contribute to the better survival prognosis observed in patients with prostate cancer lung metastases compared to those with liver metastases. The gene expression profiles in these two specific metastatic sites reveal a combination of both heterogeneity and homogeneity.PMID:38433022 | DOI:10.1016/j.urolonc.2024.01.032 (Source: Urologic Oncology)
Source: Urologic Oncology - March 3, 2024 Category: Urology & Nephrology Authors: Peng Zhang Tieding Chen Ming Yang Source Type: research
Comparative analysis of prognosis and gene expression in prostate cancer patients with site-specific visceral metastases
CONCLUSION: Patients diagnosed with mPCa and presenting with liver and/or lung metastases exhibit poorer prognoses. SCGB3A1, identified as a tumor suppressor gene, may contribute to the better survival prognosis observed in patients with prostate cancer lung metastases compared to those with liver metastases. The gene expression profiles in these two specific metastatic sites reveal a combination of both heterogeneity and homogeneity.PMID:38433022 | DOI:10.1016/j.urolonc.2024.01.032 (Source: Urologic Oncology)
Source: Urologic Oncology - March 3, 2024 Category: Urology & Nephrology Authors: Peng Zhang Tieding Chen Ming Yang Source Type: research
Comparative analysis of prognosis and gene expression in prostate cancer patients with site-specific visceral metastases
CONCLUSION: Patients diagnosed with mPCa and presenting with liver and/or lung metastases exhibit poorer prognoses. SCGB3A1, identified as a tumor suppressor gene, may contribute to the better survival prognosis observed in patients with prostate cancer lung metastases compared to those with liver metastases. The gene expression profiles in these two specific metastatic sites reveal a combination of both heterogeneity and homogeneity.PMID:38433022 | DOI:10.1016/j.urolonc.2024.01.032 (Source: Urologic Oncology)
Source: Urologic Oncology - March 3, 2024 Category: Urology & Nephrology Authors: Peng Zhang Tieding Chen Ming Yang Source Type: research
Performance of standard systematic biopsy versus MRI/TRUS fusion biopsy using the Navigo ® system in contemporary cohort
CONCLUSIONS: Detection of csPca by mpMRI/TRUS fusion biopsy using the 3D Navigo™ system is feasible. The targeted approach outperforms the systematic one, however the later technique also detects high risk disease and should be included in the biopsy procedure. The overall detection rate (34.9%) of clinically significant prostate cancer by both targeted and systematic sampling is relatively low.PMID:38431487 | DOI:10.1016/j.urolonc.2024.01.026 (Source: Urologic Oncology)
Source: Urologic Oncology - March 2, 2024 Category: Urology & Nephrology Authors: Omri Nativ Alexander Shefler Jacob Bejar Solomon Peschansky Arnon Lavi Cohen Michael Ofer Nativ Source Type: research
The role of neoadjuvant chemotherapy for patients with variant histology muscle invasive bladder cancer undergoing robotic cystectomy: Data from the International Robotic Cystectomy Consortium
CONCLUSION: Our data showed no significant difference in OS, RFS, or DSS for patients with VH MIBC cancer who received NAC before RARC. Patients with the squamous variant who received NAC had more pathologic downstaging compared to those who did not. The role of NAC among patients with VH is yet to be defined. Results were limited by small number in each individual group and lack of exact proportion of VH.PMID:38429124 | DOI:10.1016/j.urolonc.2024.01.002 (Source: Urologic Oncology)
Source: Urologic Oncology - March 1, 2024 Category: Urology & Nephrology Authors: Ian Cooke Nassib Abou Heidar Abdul Wasay Mahmood Ali Ahmad Zhe Jing Michael St öckle Andrew A Wagner Morgan Roupret Eric Kim Nikhil Vasdev Derya Balbay Koon Ho Rha Ahmed Aboumohamed Prokar Dasgupta Thomas J Maatman Lee Richstone Peter Wiklund Franco Gabo Source Type: research
The role of neoadjuvant chemotherapy for patients with variant histology muscle invasive bladder cancer undergoing robotic cystectomy: Data from the International Robotic Cystectomy Consortium
CONCLUSION: Our data showed no significant difference in OS, RFS, or DSS for patients with VH MIBC cancer who received NAC before RARC. Patients with the squamous variant who received NAC had more pathologic downstaging compared to those who did not. The role of NAC among patients with VH is yet to be defined. Results were limited by small number in each individual group and lack of exact proportion of VH.PMID:38429124 | DOI:10.1016/j.urolonc.2024.01.002 (Source: Urologic Oncology)
Source: Urologic Oncology - March 1, 2024 Category: Urology & Nephrology Authors: Ian Cooke Nassib Abou Heidar Abdul Wasay Mahmood Ali Ahmad Zhe Jing Michael St öckle Andrew A Wagner Morgan Roupret Eric Kim Nikhil Vasdev Derya Balbay Koon Ho Rha Ahmed Aboumohamed Prokar Dasgupta Thomas J Maatman Lee Richstone Peter Wiklund Franco Gabo Source Type: research
Development of a microultrasound-based nomogram to predict extra-prostatic extension in patients with prostate cancer undergoing robot-assisted radical prostatectomy
CONCLUSION: We developed a microultrasound-based nomogram for the prediction of extra-prostatic extension that could aid in the decision whether to preserve or not neurovascular bundles. External validation and a direct comparison with mpMRI-based nomogram is crucial to corroborate our results.PMID:38423852 | DOI:10.1016/j.urolonc.2024.01.033 (Source: Urologic Oncology)
Source: Urologic Oncology - February 29, 2024 Category: Urology & Nephrology Authors: Nicola Frego Roberto Contieri Vittorio Fasulo Davide Maffei Pier Paolo Avolio Paola Arena Edoardo Beatrici Federica Sordelli Fabio De Carne Massimo Lazzeri Alberto Saita Rodolfo Hurle Nicol ò Maria Buffi Paolo Casale Giovanni Lughezzani Source Type: research
Development of a microultrasound-based nomogram to predict extra-prostatic extension in patients with prostate cancer undergoing robot-assisted radical prostatectomy
CONCLUSION: We developed a microultrasound-based nomogram for the prediction of extra-prostatic extension that could aid in the decision whether to preserve or not neurovascular bundles. External validation and a direct comparison with mpMRI-based nomogram is crucial to corroborate our results.PMID:38423852 | DOI:10.1016/j.urolonc.2024.01.033 (Source: Urologic Oncology)
Source: Urologic Oncology - February 29, 2024 Category: Urology & Nephrology Authors: Nicola Frego Roberto Contieri Vittorio Fasulo Davide Maffei Pier Paolo Avolio Paola Arena Edoardo Beatrici Federica Sordelli Fabio De Carne Massimo Lazzeri Alberto Saita Rodolfo Hurle Nicol ò Maria Buffi Paolo Casale Giovanni Lughezzani Source Type: research
Functional and oncologic outcomes of prostate capsule-sparing radical cystectomy: A systematic review and meta-analysis
Urol Oncol. 2024 Feb 27:S1078-1439(24)00009-7. doi: 10.1016/j.urolonc.2024.01.008. Online ahead of print.ABSTRACTRadical cystectomy (RC) is the gold standard treatment for patients with organ-confined bladder cancer. However, despite the success of this treatment, many men who undergo orthotopic neobladder substitution develop significant erectile dysfunction and urinary symptoms, including daytime and nighttime urinary incontinence. Prostate-capsule-sparing radical cystectomy (PCS-RC) with orthotopic neobladder (ONB) has been described in the literature as a surgical technique to improve functional outcomes in appropriate...
Source: Urologic Oncology - February 28, 2024 Category: Urology & Nephrology Authors: Christopher P Dall James B Mason Charlotte C Goldman Grant Fabrizio Emily C Alagha Jiling Chou Keith J Kowalczyk Piyush K Agarwal Lambros Stamatakis Ross E Krasnow Source Type: research
Survivin as a potential biomarker in the diagnosis of bladder cancer: A systematic review and meta-analysis
Urol Oncol. 2024 Feb 27:S1078-1439(24)00019-X. doi: 10.1016/j.urolonc.2024.01.018. Online ahead of print.ABSTRACTEarly detection, diagnosis, and treatment take on critical significance in preventing and treating bladder cancer. As indicated by numerous studies, survivin can serve as a biomarker of bladder cancer, whereas the results of a wide variety of studies have been controversial. This paper is to assess the accuracy of survivin in the diagnosis of bladder cancer by a meta-analysis. The studies regarding the diagnosis of bladder cancer using survivin were systematically retrieved from the CNKI, WanFang, CBM, VIP, Web ...
Source: Urologic Oncology - February 28, 2024 Category: Urology & Nephrology Authors: Zhiren Zhou Lina Zou Yue Guan Lizhe Jiang Yanan Liu Xueqing Zhang Xiaojing Huang Huanyu Ren Zheng Li Huiru Niu Hao Liao Xiaojing Zhang Hongzhi Pan Shengzhong Rong Hongkun Ma Source Type: research
Simulation of the effects of molecular urine markers in follow-up of patients with high-risk non-muscle invasive bladder cancer
Urol Oncol. 2024 Feb 24:S1078-1439(24)00041-3. doi: 10.1016/j.urolonc.2024.01.025. Online ahead of print.ABSTRACTA plethora of urine markers for the management of patients with bladder cancer has been developed and studied in the past. However, the clinical impact of urine testing on patient management remains obscure. The goal of this manuscript is to identify scenarios for the potential use of molecular urine markers in the follow-up of patients with high-risk non-muscle-invasive BC (NMIBC) and estimate potential risks and benefits. Information on the course of disease of patients with high-risk NMIBC and performance dat...
Source: Urologic Oncology - February 25, 2024 Category: Urology & Nephrology Authors: Natalya Benderska-S öder Thorsten Ecke Lisa Kleinlein Florian Roghmann Ekkehardt Bismarck Bas W G van Rhijn Arnulf Stenzl Johannes Alfred Witjes Tilman Todenh öfer Oliver W Hakenberg Marc Oliver Grimm Peter J Goebell Maximilian Burger Jorgen Bjerggaard Source Type: research
Simulation of the effects of molecular urine markers in follow-up of patients with high-risk non-muscle invasive bladder cancer
Urol Oncol. 2024 Feb 24:S1078-1439(24)00041-3. doi: 10.1016/j.urolonc.2024.01.025. Online ahead of print.ABSTRACTA plethora of urine markers for the management of patients with bladder cancer has been developed and studied in the past. However, the clinical impact of urine testing on patient management remains obscure. The goal of this manuscript is to identify scenarios for the potential use of molecular urine markers in the follow-up of patients with high-risk non-muscle-invasive BC (NMIBC) and estimate potential risks and benefits. Information on the course of disease of patients with high-risk NMIBC and performance dat...
Source: Urologic Oncology - February 25, 2024 Category: Urology & Nephrology Authors: Natalya Benderska-S öder Thorsten Ecke Lisa Kleinlein Florian Roghmann Ekkehardt Bismarck Bas W G van Rhijn Arnulf Stenzl Johannes Alfred Witjes Tilman Todenh öfer Oliver W Hakenberg Marc Oliver Grimm Peter J Goebell Maximilian Burger Jorgen Bjerggaard Source Type: research
Simulation of the effects of molecular urine markers in follow-up of patients with high-risk non-muscle invasive bladder cancer
Urol Oncol. 2024 Feb 24:S1078-1439(24)00041-3. doi: 10.1016/j.urolonc.2024.01.025. Online ahead of print.ABSTRACTA plethora of urine markers for the management of patients with bladder cancer has been developed and studied in the past. However, the clinical impact of urine testing on patient management remains obscure. The goal of this manuscript is to identify scenarios for the potential use of molecular urine markers in the follow-up of patients with high-risk non-muscle-invasive BC (NMIBC) and estimate potential risks and benefits. Information on the course of disease of patients with high-risk NMIBC and performance dat...
Source: Urologic Oncology - February 25, 2024 Category: Urology & Nephrology Authors: Natalya Benderska-S öder Thorsten Ecke Lisa Kleinlein Florian Roghmann Ekkehardt Bismarck Bas W G van Rhijn Arnulf Stenzl Johannes Alfred Witjes Tilman Todenh öfer Oliver W Hakenberg Marc Oliver Grimm Peter J Goebell Maximilian Burger Jorgen Bjerggaard Source Type: research
