Deep Learning-Based Prediction of Radiation Therapy Dose Distributions in Nasopharyngeal Carcinomas: A Preliminary Study Incorporating Multiple Features Including Images, Structures, and Dosimetry
Conclusions: This study presents a novel framework for dose distribution prediction using deep learning and multichannel input, specifically incorporating TCPD information, enhancing prediction accuracy for IMRT in NPC treatment.PMID:38808514 | DOI:10.1177/15330338241256594 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - May 29, 2024 Category: Cancer & Oncology Authors: Yixuan Wang Zun Piao Huikuan Gu Meining Chen Dandan Zhang Jinhan Zhu Source Type: research
Prognostication of Hepatocellular Carcinoma Using Artificial Intelligence
Korean J Radiol. 2024 Jun;25(6):550-558. doi: 10.3348/kjr.2024.0070.ABSTRACTHepatocellular carcinoma (HCC) is a biologically heterogeneous tumor characterized by varying degrees of aggressiveness. The current treatment strategy for HCC is predominantly determined by the overall tumor burden, and does not address the diverse prognoses of patients with HCC owing to its heterogeneity. Therefore, the prognostication of HCC using imaging data is crucial for optimizing patient management. Although some radiologic features have been demonstrated to be indicative of the biologic behavior of HCC, traditional radiologic methods for ...
Source: Korean Journal of Radiology - May 29, 2024 Category: Radiology Authors: Subin Heo Hyo Jung Park Seung Soo Lee Source Type: research
Higher expression of SALL4-A isoform is correlated with worse outcomes and progression of the disease in subtype of testicular germ cell tumors
CONCLUSIONS: SALL4-A isoform expression in the cytoplasm and nucleus of TGCTs may be associated with histological differentiation. In the seminoma subtype of TGCTs, higher expression of SALL4-A may be used as a predictive indicator of poorer outcomes and prognosis.PMID:38808385 | DOI:10.1080/1354750X.2024.2361796 (Source: Biomarkers)
Source: Biomarkers - May 29, 2024 Category: Research Authors: Niknam Lakpour Roya Ghods Maryam Abolhasani Leili Saeednejad Zanjani Kioomars Saliminejad Elham Kalantari Sima Saki Mohammad Mehdi Ranjbar Leila Balay-Goli Mohammad Reza Sadeghi Zahra Madjd Source Type: research
Diagnostic Value of Dermoscopic Structures in Predicting Superficial Basal Cell Carcinoma in the Skin of Color
CONCLUSION: Dermoscopy exhibited superior specificity compared to the naked eye in differentiating superficial BCC from other BCC types. Notably, the spoke-wheel structure demonstrated the most robust correlation with superficial BCC.PMID:38808321 | PMC:PMC11132197 | DOI:10.4103/abr.abr_315_23 (Source: Cell Research)
Source: Cell Research - May 29, 2024 Category: Cytology Authors: Maryam Khalili Sare Mirahmadi Simin Shamsimeymandi Shahriar Dabiri Rezvan Amiri Mohammad Rezaei Zadeh Rukerd Mahin Aflatoonian Source Type: research
Advances in combined neuroendocrine carcinoma of lung cancer
This study focuses specifically on combined pulmonary carcinomas with a neuroendocrine component. In this comprehensive review article, the authors provide an overview of combined lung cancers and present two pathological images to visually depict these distinctive subtypes.PMID:38807858 | PMC:PMC11130380 | DOI:10.3389/pore.2024.1611693 (Source: Cell Research)
Source: Cell Research - May 29, 2024 Category: Cytology Authors: Zesen Han Fujun Yang Fang Wang Huayu Zheng Xiujian Chen Hongyu Meng Fenglei Li Source Type: research
Evolution of publicly available large language models for complex decision-making in breast cancer care
ConclusionThis early feasibility study is the first to compare different LLM in breast cancer care with regard to changes in accuracy over time, i.e., with access to more data or through technological upgrades. Methodological advancement, i.e., the optimization of prompting techniques, and technological development, i.e., enabling data input control and secure data processing, are necessary in the preparation of large-scale and multicenter studies to provide evidence on their safe and reliable clinical application. At present, safe and evidenced use of LLM in clinical breast cancer care is not yet feasible. (Source: Archiv...
Source: Archives of Gynecology and Obstetrics - May 29, 2024 Category: OBGYN Source Type: research
Performance of LI-RADS category 5 vs combined categories 4 and 5: a systemic review and meta-analysis
ConclusionsOur meta-analysis showed that combining LR-4 and LR-5 would increase sensitivity but decrease specificity, positive likelihood ratio, and negative likelihood ratio. These findings may inform management guidelines and individualized management.Clinical relevance statementThis meta-analysis estimated the magnitude of changes in the sensitivity and specificity of imaging criteria when LI-RADS categories 4 and 5 were combined; these findings can inform management guidelines and individualized management.Key PointsThere is no single worldwide reporting system for liver imaging, partly due to regional needs.Combining ...
Source: European Radiology - May 29, 2024 Category: Radiology Source Type: research
Survival benefit of postoperative radioiodine therapy among patients with intermediate-risk differentiated thyroid carcinoma
ConclusionsRAIT improves OS and CSS in patients with intermediate-risk DTC after surgery. 55 years is a more appropriate prognostic age cutoff for the relevant classification systems and is a crucial consideration in RAI decision-making. Therefore, we need individualized treatment plans. (Source: Endocrine)
Source: Endocrine - May 29, 2024 Category: Endocrinology Source Type: research
Optimizing the detection of hereditary predisposition in women with epithelial ovarian cancer: nationwide implementation of the Tumor-First workflow
We present an example of a nationwide implementation project that has successfully led to a uniform, high-quality genetic-testing workflow for women w ith OC. Nationwide multidisciplinary meetings generated consensus on the preferred workflow for OC genetic testing: the “Tumor-First” workflow. This workflow means starting by testing the tumor DNA for the presence of pathogenic variants in OC-risk genes, thus providing a prescreen to germline t esting while yielding information on the effectiveness of treatment with PARP inhibitors. This new workflow efficiently stratifies genetic counseling and germline testing and red...
Source: Familial Cancer - May 29, 2024 Category: Cancer & Oncology Source Type: research
Statins in Chronic Liver Disease: Review of the Literature and Future Role
Semin Liver Dis DOI: 10.1055/a-2319-0694 Chronic liver disease (CLD) is a major contributor to global mortality, morbidity, and healthcare burden. Progress in pharmacotherapeutic for CLD management is lagging given its impact on the global population. While statins are indicated for the management of dyslipidemia and cardiovascular disease, their role in CLD prevention and treatment is emerging. Beyond their lipid-lowering effects, their liver-related mechanisms of action are multifactorial and include anti-inflammatory, antiproliferative, and immune-protective effects. In this review, we highlight what is known about the ...
Source: Seminars in Liver Disease - May 29, 2024 Category: Gastroenterology Authors: Pham, Nguyen Benhammou, Jihane N. Tags: Review Article Source Type: research
The enhanced energy metabolism in the tumor margin mediated by RRAD promotes the progression of oral squamous cell carcinoma
Cell Death & Disease, Published online: 29 May 2024; doi:10.1038/s41419-024-06759-7The enhanced energy metabolism in the tumor margin mediated by RRAD promotes the progression of oral squamous cell carcinoma (Source: Cell death and disease)
Source: Cell death and disease - May 29, 2024 Category: Internal Medicine Authors: Aoming Cheng Qiaoshi Xu Bo Li Lirui Zhang Hao Wang Chang Liu Zhengxue Han Zhien Feng Source Type: research
Letter to the editor for the article “Tumor margin irregularity degree is an important preoperative predictor of adverse pathology for clinical T1/2 renal cell carcinoma and the construction of predictive model”
(Source: World Journal of Urology)
Source: World Journal of Urology - May 29, 2024 Category: Urology & Nephrology Source Type: research
Evolution of publicly available large language models for complex decision-making in breast cancer care
ConclusionThis early feasibility study is the first to compare different LLM in breast cancer care with regard to changes in accuracy over time, i.e., with access to more data or through technological upgrades. Methodological advancement, i.e., the optimization of prompting techniques, and technological development, i.e., enabling data input control and secure data processing, are necessary in the preparation of large-scale and multicenter studies to provide evidence on their safe and reliable clinical application. At present, safe and evidenced use of LLM in clinical breast cancer care is not yet feasible. (Source: Archiv...
Source: Archives of Gynecology and Obstetrics - May 29, 2024 Category: OBGYN Source Type: research
Cost-effectiveness analysis of tislelizumab vs. camrelizumab for the treatment of second-line locally advanced or metastatic esophageal squamous cell carcinoma
Esophageal carcinoma is a type of cancer that occurs in the esophagus. For patients with locally advanced or metastatic esophageal squamous cell carcinoma who have either experienced disease progression follow... (Source: BMC Health Services Research)
Source: BMC Health Services Research - May 29, 2024 Category: General Medicine Authors: Pingyu Chen, Chang Fu, Lin Shen, Zhengyang Fei, Mengjie Luo, Yanqiu Chen and Hongchao Li Tags: Research Source Type: research
Exploring the Landscape of Salivary Gland Disorders: A Comprehensive Bibliometric Analysis
ConclusionThis study provides a comprehensive overview of the field, offering insights into influential work, collaborative networks, and emerging trends. The outputs of the analysis can guide researchers and clinicians in shaping future investigations. (Source: Journal of Maxillofacial and Oral Surgery)
Source: Journal of Maxillofacial and Oral Surgery - May 29, 2024 Category: ENT & OMF Source Type: research
