Artificial Intelligence –assisted chest X-ray assessment scheme for COVID-19
ConclusionThis study shows how deployment of an AI algorithm can complement a human expert in the determination of COVID status. Analysis of the detected features suggests possible subtle cardiac changes, laying ground for further investigative studies into possible cardiac changes.Key Points• Through an ambispective clinical study, we show how assistance with an AI algorithm can improve recall (sensitivity) and precision (positive predictive value) of radiologists in assessing CXR for possible COVID in comparison to RT-PCR.• We show that AI achieves the best results in images classified as “normal” b...
Source: European Radiology - July 9, 2021 Category: Radiology Source Type: research

Single-energy CT predicts uric acid stones with accuracy comparable to dual-energy CT —prospective validation of a quantitative method
ConclusionA quantitative SE-CT method (kNN-ppLapl-maxHU) can classify UA stones with accuracy comparable to DE-CT.Key Points•Single-energy CT is the first-line diagnostic tool for suspected renal colic.•A single-energy CT method based on the internal urinary stone attenuation distribution can classify urinary stones into uric acid and non-uric acid stones with high accuracy.•This immensely increases the availability of in vivo stone analysis. (Source: European Radiology)
Source: European Radiology - July 9, 2021 Category: Radiology Source Type: research

Enhancement degree of brain metastases: correlation analysis between enhanced T2 FLAIR and vascular permeability parameters of dynamic contrast-enhanced MRI
AbstractObjectivesTo investigate the correlation between enhancement degrees of brain metastases on contrast-enhanced T2-fluid-attenuated inversion recovery (CE-T2 FLAIR) and vascular permeability parameters of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI).MethodsThirty-nine patients with brain metastases were prospectively collected. They underwent non-enhanced T2 FLAIR, DCE-MRI, CE-T2 FLAIR, and contrast-enhanced three-dimensional brain volume imaging (CE-BRAVO). Quantitative parameters of DCE-MRI were evaluated for all lesions, which included volume transfer constant (Ktrans), rate constant (Kep), and f...
Source: European Radiology - July 9, 2021 Category: Radiology Source Type: research

Editorial comment on “A new method for quantification and 3D visualization of brain tumor adhesion using slip interface imaging in patients with meningiomas”
(Source: European Radiology)
Source: European Radiology - July 9, 2021 Category: Radiology Source Type: research

Breast MRI in the setting of DCIS: quality trials are still needed to determine its value
Key Points• Existing evidence suggests that preoperative breast MRI does not improve treatment outcomes for DCIS.• The quality of the available data used to answer this question is poor.• Quality randomized controlled trials are needed to definitively assess the benefits and harms of preoperative MRI in the setting of DCIS. (Source: European Radiology)
Source: European Radiology - July 9, 2021 Category: Radiology Source Type: research

Myocardial stress perfusion in asymptomatic patients: the silent ischemia makes the loudest sound
(Source: European Radiology)
Source: European Radiology - July 9, 2021 Category: Radiology Source Type: research

Radiomics analysis of MR neonatal brain: will it be the Rosetta stone for predicting the poor psychomotor outcome in preterm newborns?
(Source: European Radiology)
Source: European Radiology - July 9, 2021 Category: Radiology Source Type: research

Radiomics and deep learning methods in expanding the use of screening breast MRI
Key Points• The use of screening breast MRI is expanding beyond high-risk women to include intermediate- and average-risk women.• The study by Pötsch et al uses a radiomics-based method to decrease the number of benign biopsies while maintaining high sensitivity.• Future studies will likely increasingly focus on deep learning methods and abbreviated MRI data. (Source: European Radiology)
Source: European Radiology - July 9, 2021 Category: Radiology Source Type: research

Correction to: Image quality of ultralow-dose chest CT using deep learning techniques: potential superiority of vendor-agnostic post-processing over vendor-specific techniques
A Correction to this paper has been published:https://doi.org/10.1007/s00330-021-07733-z (Source: European Radiology)
Source: European Radiology - July 9, 2021 Category: Radiology Source Type: research

A CT-based radiomics nomogram for differentiation of squamous cell carcinoma and non-Hodgkin ’s lymphoma of the palatine tonsil
ConclusionsA CECT-based radiomics nomogram was constructed incorporating gender, mean CECT value, and radiomics signature. This nomogram showed favorable predictive efficacy for differentiating SCC from NHL in the palatine tonsil, and might be useful for clinical decision-making.Key Points•Differential diagnosis between SCC and NHL in the palatine tonsil is difficult by conventional imaging modalities.•A radiomics nomogram integrated with the radiomics signature, gender, and mean contrast-enhanced CT value facilitates differentiation of SCC from NHL with improved diagnostic efficacy. (Source: European Radiology)
Source: European Radiology - July 8, 2021 Category: Radiology Source Type: research

Evaluation of quantitative MRCP (MRCP+) for risk stratification of primary sclerosing cholangitis: comparison with morphological MRCP, MR elastography, and biochemical risk scores
ConclusionsMRCP+ demonstrated a significant association with biochemical scores and MRE. The association of MRCP+ with the biochemical scores was generally comparable to ANALI scores. MRCP+ enhanced the association of ANALI2 and MRE with the Mayo Risk Score.Key Points• MRCP+ has the potential to act as a risk stratfier in PSC.• MRE outperformed MRCP+ for risk stratifcation.• Combination of MRCP+ with MRE and ANALI scores improved overall performace as risk stratifiers. (Source: European Radiology)
Source: European Radiology - July 6, 2021 Category: Radiology Source Type: research

Postoperative radiological assessment of the mastoid facial canal in cochlear implant patients in correlation with facial nerve stimulation
ConclusionThe mastoid-facial canal radiological assessment and the positional relationship with the CI electrode provide no predictor of postoperative FNS. Histories of meningitis/encephalitis and extracochlear-electrode-contacts are important risk factors.Key Points• Post-operative radiological assessment of the mastoid facial canal and the positional relationship with the CI electrode provide no predictor of post-cochlear implant facial nerve stimulation.• Radiological detection of extracochlear electrode contacts and the previous clinical history of meningitis/encephalitis are two important risk factors for po...
Source: European Radiology - July 5, 2021 Category: Radiology Source Type: research

Radiomic machine learning for predicting prognostic biomarkers and molecular subtypes of breast cancer using tumor heterogeneity and angiogenesis properties on MRI
AbstractObjectivesTo investigate machine learning approaches for radiomics-based prediction of prognostic biomarkers and molecular subtypes of breast cancer using quantification of tumor heterogeneity and angiogenesis properties on magnetic resonance imaging (MRI).MethodsThis prospective study examined 291 invasive cancers in 288 patients who underwent breast MRI at 3 T before treatment between May 2017 and July 2019. Texture and perfusion analyses were performed and a total of 160 parameters for each cancer were extracted. Relationships between MRI parameters and prognostic biomarkers were analyzed using five machine lear...
Source: European Radiology - July 5, 2021 Category: Radiology Source Type: research

Artificial intelligence for prediction of COVID-19 progression using CT imaging and clinical data
This study aimed to develop an artificial intelligence system to predict future deterioration to critical illness in COVID-19 patients.MethodsAn artificial intelligence (AI) system in a time-to-event analysis framework was developed to integrate chest CT and clinical data for risk prediction of future deterioration to critical illness in patients with COVID-19.ResultsA multi-institutional international cohort of 1,051 patients with RT-PCR confirmed COVID-19 and chest CT was included in this study. Of them, 282 patients developed critical illness, which was defined as requiring ICU admission and/or mechanical ventilation an...
Source: European Radiology - July 5, 2021 Category: Radiology Source Type: research

Correction to: Effectiveness of percutaneous vacuum-assisted excision (VAE) of breast lesions of uncertain malignant potential (B3 lesions) as an alternative to open surgical biopsy
A Correction to this paper has been published:https://doi.org/10.1007/s00330-021-08157-5 (Source: European Radiology)
Source: European Radiology - July 5, 2021 Category: Radiology Source Type: research

Influence of aging and gadolinium exposure on T1, T2, and T2*-relaxation in healthy women with an increased risk of breast cancer with and without prior exposure to gadoterate meglumine at 3.0-T brain MR imaging
We examined the effects of aging and of gadolinium-based contrast agent (GBCA) exposure on MRI measurements in brain nuclei of healthy women.MethodsThis prospective, IRB-approved single-center case-control study enrolled 100 healthy participants of our high-risk screening center for hereditary breast cancer, who had received at least six doses of macrocyclic GBCA (exposed group) or were newly entering the program (GBCA-na ïve group). The cutoff “at least six doses” was chosen to be able to include a sufficient number of highly exposed participants. All participants underwent unenhanced 3.0-T brain MRI incl...
Source: European Radiology - July 3, 2021 Category: Radiology Source Type: research

Differentiating thymoma, thymic carcinoma and lymphoma based on collagen fibre patterns with T2- and diffusion-weighted magnetic resonance imaging
AbstractObjectivesThe amount and distribution of intratumoural collagen fibre vary among different thymic tumours, which can be clearly detected with T2- and diffusion-weighted MR images. To explore the incidences of collagen fibre patterns (CFPs) among thymomas, thymic carcinomas and lymphomas on imaging, and to evaluate the efficacy and reproducibility of CFPs in differential diagnosis of thymic tumours.Materials and methodsThree hundred and ninety-eight patients with pathologically diagnosed thymoma, thymic carcinoma and lymphoma who underwent T2- and diffusion-weighted MR imaging were retrospectively enrolled. CFPs wer...
Source: European Radiology - July 2, 2021 Category: Radiology Source Type: research

Comprehensive comparison of dual-energy computed tomography and magnetic resonance imaging for the assessment of bone marrow edema and fracture lines in acute vertebral fractures
AbstractObjectivesTo compare dual-energy CT (DECT) and MRI for assessing presence and extent of traumatic bone marrow edema (BME) and fracture line depiction in acute vertebral fractures.MethodsEighty-eight consecutive patients who underwent dual-source DECT and 3-T MRI of the spine were retrospectively analyzed. Five radiologists assessed all vertebrae for presence and extent of BME and for identification of acute fracture lines on MRI and, after 12 weeks, on DECT series. Additionally, image quality, image noise, and diagnostic confidence for overall diagnosis of acute vertebral fracture were assessed. Quantitative analys...
Source: European Radiology - July 2, 2021 Category: Radiology Source Type: research

Long-term MRI-guided vacuum-assisted breast biopsy results of 600 single-center procedures
ConclusionThe accuracy of MRI-guided VABB is high with a very low false negative rate of 0.3% on long-term follow-up. The value of short-term FU-MRI for every case after MRI-guided VABB may be questioned.Key Points• MRI-guided vacuum-assisted breast biopsies yield a large portion of clinically relevant lesions (9.82% B3, 0.17% B4, and 27.67% B5 lesions).• The false negative biopsy rate of MRI-guided VABB in this study with a mean follow-up time of 7.6 years was only 0.3%.• Performing a short-term follow-up MRI after a benign MRI-guided VABB concordant to the MRI appearance may be questioned. (Source: European Radiology)
Source: European Radiology - June 18, 2021 Category: Radiology Source Type: research

Implications of US radiomics signature for predicting malignancy in thyroid nodules with indeterminate cytology
AbstractObjectivesThe purpose of this study was to evaluate the role of the radiomics score using US images to predict malignancy in AUS/FLUS and FN/SFN nodules.MethodsOne hundred fifty-five indeterminate thyroid nodules in 154 patients who received initial US-guided FNA for diagnostic purposes were included in this retrospective study. A representative US image of each tumor was acquired, and square ROIs covering the whole nodule were drawn using the Paint program of Windows 7. Texture features were extracted by in-house texture analysis algorithms implemented in MATLAB 2019b. The LASSO logistic regression model was used ...
Source: European Radiology - June 18, 2021 Category: Radiology Source Type: research

Fusion of high b-value diffusion-weighted and unenhanced T1-weighted images to diagnose invasive breast cancer: factors associated with false-negative results
AbstractObjectivesWe sought factors associated with false-negative results in the diagnosis of invasive breast cancer via non-contrast breast magnetic resonance imaging (MRI) using fused highb-value diffusion-weighted imaging (DWI) and unenhanced T1-weighted images (T1WI).MethodsBetween 2018 and 2019, 316 consecutive women (mean age, 54.6 years) with invasive breast cancer who underwent preoperative breast MRI, including fused highb-value DWI and unenhanced T1WI, were retrospectively evaluated. Malignancy confidence ratings of the most suspicious breast lesions evident on fused DWI were derived by two radiologists using a ...
Source: European Radiology - June 18, 2021 Category: Radiology Source Type: research

Claustrophobia —empowering the patient
Key Points• Claustrophobia, a phobic anxiety disorder, is a well-known relative contraindication for MR, and anxiety or fear is triggered by confinement or the prospect of confinement in the MR environment.• Within the field of MR, claustrophobia is generally counteracted by reducing or deflecting attention from triggering stimuli in the MR environment by technical means, which increases relaxation and comfort and thus improves compliance.• Psychological interventions and self-empowerment of patients might become the next level of coping strategies. (Source: European Radiology)
Source: European Radiology - June 18, 2021 Category: Radiology Source Type: research

Translation of predictive modeling and AI into clinics: a question of trust
(Source: European Radiology)
Source: European Radiology - June 18, 2021 Category: Radiology Source Type: research

Diagnostic interval for non-screening patients undergoing mammography during the COVID-19 pandemic
The objective of this study was to evaluate changes in thediagnostic interval (DI) of non-screening patients presenting for diagnostic mammography during the first wave of the COVID-19 pandemic.MethodsRetrospective chart review was performed on patients presenting for non-screening diagnostic mammography from April 1 to June 30, 2020 (pandemic group) and April 1 to June 30, 2019 (pre-pandemic group). Age, reason for referral, number and type of imaging studies/biopsies necessary for a final diagnosis were recorded. Diagnostic interval (DI) was defined as the number of days from the date of the diagnostic mammogram to the d...
Source: European Radiology - June 18, 2021 Category: Radiology Source Type: research

Subtraction improves the accuracy of coronary CT angiography for detecting obstructive disease in severely calcified segments
AbstractObjectiveTo investigate the accuracy, diagnostic confidence, and interobserver agreement of subtraction coronary CT angiography (CCTA) versus invasive coronary angiography on 320-row CT in coronary segments with severe or non-severe calcification.Materials/methodsSixty-four patients (33 men, 66.6 ± 8.2 years) with suspected coronary artery disease (CAD) were prospectively enrolled from October 2019 to June 2020. The cross-sectional circumferential extent of calcification was used to classify calcified segments as non-severely (
Source: European Radiology - June 17, 2021 Category: Radiology Source Type: research

Prognostic value of stress cardiovascular magnetic resonance in asymptomatic patients without known coronary artery disease
AbstractObjectivesA few studies suggest a significant prognostic value of silent myocardial ischaemia detected in asymptomatic patients. However, the current guidelines do not recommend stress testing in asymptomatic individuals. To assess the long-term prognostic value of vasodilator stress perfusion cardiovascular magnetic resonance (CMR) in asymptomatic individuals without known coronary artery disease (CAD).MethodsBetween 2009 and 2011, a retrospective cohort study with a median follow-up of 9.2  years (interquartile range: 7.8–9.6) included 1,027 consecutive asymptomatic individuals with ≥ 2 cardiovascul...
Source: European Radiology - June 17, 2021 Category: Radiology Source Type: research

Correction to: Volumetric assessment of the periablational safety margin after thermal ablation of colorectal liver metastases
A Correction to this paper has been published:https://doi.org/10.1007/s00330-020-07579-x (Source: European Radiology)
Source: European Radiology - June 17, 2021 Category: Radiology Source Type: research

Correction to: Staging, recurrence and follow-up of uterine cervical cancer using MRI: Updated Guidelines of the European Society of Urogenital Radiology after revised FIGO staging 2018
A Correction to this paper has been published: 10.1007/s00330-021-08066-7 (Source: European Radiology)
Source: European Radiology - June 17, 2021 Category: Radiology Source Type: research

Machine learning identifies factors related to early joint space narrowing in dysplastic and non-dysplastic hips
AbstractObjectivesTo utilise machine learning, unsupervised clustering and multivariate modelling in order to predict severe early joint space narrowing (JSN) from anatomical hip parameters while identifying factors related to joint space width (JSW) in dysplastic and non-dysplastic hips.MethodsA total of 507 hip CT examinations of patients 20 –55 years old were retrospectively examined, and JSW, center-edge (CE) angle, alpha angle, anterior acetabular sector angle (AASA), and neck-shaft angle (NSA) were recorded. Dysplasia and severe JSN were defined with CE angle
Source: European Radiology - June 17, 2021 Category: Radiology Source Type: research

Volumetric ADC histogram analysis for preoperative evaluation of LVSI status in stage I endometrioid adenocarcinoma
AbstractObjectivesTo investigate the value of volumetric ADC histogram metrics for evaluating lymphovascular space invasion (LVSI) status in stage I endometrioid adenocarcinoma (EAC).MethodsPreoperative MRI of 227 patients with stage I EAC were retrospectively analyzed. ADC histogram data were derived from the whole tumor with ROIs drawn on all slices of DWI scans (b = 0, 1000 s/mm2). The Studentt-test was performed to compare ADC histogram metrics (minADC, maxADC, and meanADC; 10th, 25th, 50th, 75th, and 90th percentiles of ADC; skewness; and kurtosis) between the LVSI-positive and LVSI-negative groups, as well as between...
Source: European Radiology - June 17, 2021 Category: Radiology Source Type: research

A compact and mobile hybrid C-arm scanner for simultaneous nuclear and fluoroscopic image guidance
ConclusionDue to the divergent innovative hybrid design of IXSI, concessions were made to the nuclear and fluoroscopic image qualities. Nevertheless, IXSI realizes unique image guidance that may be beneficial for several types of procedures.Key Points• IXSI can perform time-resolved planar (2D) simultaneous fluoroscopic and nuclear imaging.• IXSI can perform SPECT/CBCT imaging (3D) inside the intervention room. (Source: European Radiology)
Source: European Radiology - June 16, 2021 Category: Radiology Source Type: research

A clinicopathological study of lung adenocarcinomas with pure ground-glass opacity & gt; 3 cm on high-resolution computed tomography
ConclusionsThis study demonstrated that PGGMs> 3 cm could still be AIS-MIAs. When PGGMs are encountered in clinical practice, the CT value may be the only valuable parameter to preoperatively distinguish IACs from AIS-MIAs.Key Points• Patients with pure ground-glass opacity> 3 cm in diameter are rare but can be diagnosed as adenocarcinomas in situ or minimally invasive adenocarcinomas.• The mean CT attenuation is the sole significant CT parameter that differentiates invasive adenocarcinoma from adenocarcinoma in situ or minimally invasive adenocarcinoma in patients with pure ground-glass opacity> 3 cm.&b...
Source: European Radiology - June 16, 2021 Category: Radiology Source Type: research

Left atrial function by cardiac computed tomography is a predictor of heart failure and cardiovascular death
ConclusionCCTA-derived LA function is a predictor of HF hospitalization or CV death, independent of clinical risk factors, LA volume, and LV systolic function.Key Points•Left atrial function can be automatically derived from cardiac CTA scans.•Cardiac CTA-derived left atrial function is a predictor of hospitalization for heart failure and cardiovascular death.•Evaluation of left atrial function could be useful in identifying patients at risk of heart failure. (Source: European Radiology)
Source: European Radiology - June 16, 2021 Category: Radiology Source Type: research

Spinal nerve signal intensity on Dixon T2-weighted water-only sequence: an important outcome predictor after lumbar transforaminal epidural injection
ConclusionsThe mean signal intensity and the nerve-to-fat signal ratio of the spinal nerve on axial Dixon T2-weighted water-only images can help predict patient response to the TFESI.Key Points• Applying the Dixon technique to lumbar spine MRI can help predict patient response to the TFESI procedure.• An increased nerve-to-fat signal ratio and mean spinal nerve signal intensity on axial Dixon T2-weighted water-only images predicted favorable TFESI outcomes. (Source: European Radiology)
Source: European Radiology - June 16, 2021 Category: Radiology Source Type: research

DEtection of ProxImal Coronary stenosis in the work-up for Transcatheter aortic valve implantation using CTA (from the DEPICT CTA collaboration)
ConclusionCTA provides high diagnostic accuracy to rule out LM and proximal coronary stenosis in patients undergoing work-up for TAVI. Clinical application of CTA as a gatekeeper for ICA would reduce the need for ICA in 52% or 70% of patients, using a threshold of ≥ 50% or ≥ 70% DS, respectively.Key Points•Clinical application of CTA as a gatekeeper for ICA would reduce the need for ICA in 52% or 70% of TAVI patients, using a threshold of ≥ 50% or ≥ 70% diameter stenosis.•The diagnostic accuracy of CTA to exclude proximal coronary stenosis in these patients is high, with a sensitivity of 96.4% and NPV...
Source: European Radiology - June 16, 2021 Category: Radiology Source Type: research

LI-RADS v2018: how to appropriately use ancillary features in category adjustment from intermediate probability of malignancy (LR-3) to probably HCC (LR-4) on gadoxetic acid –enhanced MRI
AbstractObjectivesTo determine the appropriate use of ancillary features (AFs) in upgrading LI-RADS category 3 (LR-3) to category 4 (LR-4) for hepatic nodules on gadoxetic acid –enhanced MRI.MethodsWe retrospectively analyzed MRI features of solid hepatic nodules ( ≤ 30 mm) categorized as LR-3/4 on gadoxetic acid–enhanced MRI. In LI-RADS diagnostic table-based-LR-3 observations, logistic regression analyses were performed to identify AFs suggestive of hepatocellular carcinomas (HCCs) rather than non-malignant nodules. Using McNemar’s test, the sensitivit ies and specificities of the final-LR-4 category...
Source: European Radiology - June 16, 2021 Category: Radiology Source Type: research

Tumor size in patients with severe pulmonary emphysema might be underestimated on preoperative CT
ConclusionsTumor size is significantly smaller on preoperative CT in patients with severe emphysema compared to patients without emphysema, especially in the case of large tumors. MPR measurement using the widest of three dimensions should be used to select T-stage for patients with severe emphysema.Key Points•The presence of emphysema affects the accuracy of tumor size measurements on CT.•Compared to patients without emphysema, the tumor size in severe emphysema patients tends to be measured smaller in preoperative CT than the pathological specimen.•This trend is more evident when large tumors are measured ...
Source: European Radiology - June 16, 2021 Category: Radiology Source Type: research

Deep learning image reconstruction algorithm for pancreatic protocol dual-energy computed tomography: image quality and quantification of iodine concentration
AbstractObjectivesTo evaluate the image quality and iodine concentration (IC) measurements in pancreatic protocol dual-energy computed tomography (DECT) reconstructed using deep learning image reconstruction (DLIR) and compare them with those of images reconstructed using hybrid iterative reconstruction (IR).MethodsThe local institutional review board approved this prospective study. Written informed consent was obtained from all participants. Thirty consecutive participants with pancreatic cancer (PC) underwent pancreatic protocol DECT for initial evaluation. DECT data were reconstructed at 70 keV using 40% adaptive stati...
Source: European Radiology - June 15, 2021 Category: Radiology Source Type: research

Detection of relevant extracardiac findings on coronary computed tomography angiography vs. invasive coronary angiography
AbstractObjectivesTo compare the detection of relevant extracardiac findings (ECFs) on coronary computed tomography angiography (CTA) and invasive coronary angiography (ICA) and evaluate the potential clinical benefit of their detection.MethodsThis is the prespecified subanalysis of ECFs in patients presenting with a clinical indication for ICA based on atypical angina and suspected coronary artery disease (CAD) included in the prospective single-center randomized controlled Coronary Artery Disease Management (CAD-Man) study. ECFs requiring immediate therapy and/or further workup including additional imaging were defined a...
Source: European Radiology - June 15, 2021 Category: Radiology Source Type: research

Variability of acquisition phase of computed tomography angiography in acute ischemic stroke in a real-world scenario
AbstractObjectivesThe informative value of computed tomography angiography (CTA) depends on the contrast phase in the vessels which may differ depending on the level of local expertise.MethodsWe retrospectively measured vessel contrast density from CTA scans in patients presenting with acute ischemic stroke to a comprehensive stroke center (CSC) or to one of eight primary stroke centers (PSC). CTAs were classified into arterial or venous phases as well as into 1 of 5 phases (early arterial, peak arterial, equilibrium, peak venous, and late venous).ResultsOverall, n = 871 CTAs (CSC: n = 431 (49.5%); PSC: n = 440 (50.5%)) we...
Source: European Radiology - June 15, 2021 Category: Radiology Source Type: research

Prediction of epithelial-to-mesenchymal transition molecular subtype using CT in gastric cancer
ConclusionA predictive model using patient ’s age, Lauren classification, and mural stratification on CT for EMT molecular subtype GC was made. A nomogram was built which would serve as a useful screening tool for an individualized estimate of EMT subtype.Key Points•A predictive model for epithelial-to-mesenchymal transition (EMT) subtype incorporating patient ’s age, Lauren classification, and mural stratification on CT was built.•The predictive model had high diagnostic accuracy (area under the curve (AUC) = 0.865) and was validated (bootstrap AUC = 0.860).•Adding CT findings to clinicopatholog...
Source: European Radiology - June 13, 2021 Category: Radiology Source Type: research

Usefulness of texture features of apparent diffusion coefficient maps in predicting chemoradiotherapy response in muscle-invasive bladder cancer
AbstractObjectivesTo examine the usefulness of the texture analysis (TA) of apparent diffusion coefficient (ADC) maps in predicting the chemoradiotherapy (CRT) response of muscle-invasive bladder cancer (MIBC).MethodsWe reviewed 45 MIBC patients who underwent cystectomy after CRT. CRT response was assessed through histologic evaluation of cystectomy specimens. Two radiologists determined the volume of interest for the index lesions on ADC maps of pretherapeutic 1.5-T MRI and performed TA using the LIFEx software. Forty-six texture features (TFs) were selected based on their contribution to the prediction of CRT sensitivity...
Source: European Radiology - June 13, 2021 Category: Radiology Source Type: research

Simultaneous evaluation of perfusion and morphology using GRASP MRI in hepatic fibrosis
AbstractObjectivesTo determine if golden-angle radial sparse parallel (GRASP) dynamic contrast-enhanced (DCE)-MRI allows simultaneous evaluation of perfusion and morphology in liver fibrosis.MethodsParticipants who were scheduled for liver biopsy or resection were enrolled (NCT02480972). Images were reconstructed at 12-s temporal resolution for morphologic assessment and at 3.3-s temporal resolution for quantitative evaluation. The image quality of the morphologic images was assessed on a four-point scale, and the Liver Imaging Reporting and Data System score was recorded for hepatic observations. Comparisons were made bet...
Source: European Radiology - June 12, 2021 Category: Radiology Source Type: research

Optimising breast cancer screening reading: blinding the second reader to the first reader ’s decisions
We examined whether preventing the two readers from seeing each other’s decisions (blinding) affects behaviour and outcomes.MethodsThis cohort study used data from the CO-OPS breast-screening trial (1,119,191 women from 43 screening centres in England) where all discrepant readings were arbitrated. Multilevel models were fitted using Markov chain Monte Carlo to measure whether reader 2 conformed to the decisions of reader 1 when they were not blinded, and the effect of blinding on overall rates of recall for further tests and cancer detection. Differences in positive predictive value (PPV) were assessed using Pearson...
Source: European Radiology - June 12, 2021 Category: Radiology Source Type: research

Inter-center agreement of mRECIST in transplanted patients for hepatocellular carcinoma
ConclusionsmRECIST agreement was substantial among the three observers involved. The agreement on tumor number, size, and transplant criteria ranged from moderate to almost perfect, with the highest ICCs obtained with MRI before neo-adjuvant therapies. Finally, the predictive value of mRECIST in the diagnosis of CPR was only fair.Key Points•The review of 180 radiological exams of patients with hepatocellular carcinoma before and after neo-adjuvant therapies showed that the concordance among three different raters on mRECIST diagnosis was substantial.•The inter-observer reliability on fulfilment of transplant crit...
Source: European Radiology - June 12, 2021 Category: Radiology Source Type: research

Risk factors analysis according to regional distribution of white matter hyperintensities in a stroke cohort
ConclusionsDifferent CVRF profiles were significantly related to specific WMH spatial distribution patterns in a large IS cohort.Key Points• An observational study of WMH in a large IS cohort was assessed by a modified visual evaluation.• Different CVRF profiles were significantly related to specific WMH spatial distribution patterns.• Distinct WMH anatomical patterns could be related to different pathophysiological mechanisms. (Source: European Radiology)
Source: European Radiology - June 11, 2021 Category: Radiology Source Type: research

Assessment of rapidly advancing bone age during puberty on elbow radiographs using a deep neural network model
ConclusionsAssessment of rapidly advancing bone age during puberty on elbow radiographs using our deep neural network model was similar to that of experts.Key Points• Bone age during puberty is particularly important for patients with scoliosis or limb-length discrepancy to determine the phase of the disease, which influences the timing and method of surgery.• The commonly used hand radiographs–based methods have limitations in assessing bone age during puberty due to the less prominent morphological changes of the hand and wrist bones in this period.• A deep neural network model trained with elbow rad...
Source: European Radiology - June 11, 2021 Category: Radiology Source Type: research

Maximum slope using ultrafast breast DCE-MRI at 1.5 Tesla: a potential tool for predicting breast lesion aggressiveness
AbstractObjectivesWe evaluated the relationship between the maximum slope (MS) based on ultrafast breast DCE-MRI sequences, and the clinical parameters and routine prognostic factors of breast cancer.Methods210 lesions were retrospectively evaluated: 150 malignant (30 each of luminal A invasive carcinoma, luminal B invasive carcinoma, HER2 overexpression (HER2), triple negative (TN), invasive lobular carcinoma (ILC)), and 60 benign. For each lesion, the MS was obtained with an ultrafast sequence and semi-quantitative curves were classified into three types with a conventional DCE sequence. The correlation between MS and ag...
Source: European Radiology - June 11, 2021 Category: Radiology Source Type: research

Diagnostic performance of single-phase dual-energy CT to differentiate vascular and nonvascular incidental renal lesions on portal venous phase: comparison with CT
AbstractObjectivesTo determine whether single-phase dual-energy CT (DECT) differentiates vascular and nonvascular renal lesions in the portal venous phase (PVP). Optimal iodine threshold was determined and compared to Hounsfield unit (HU) measurements.MethodsWe retrospectively included 250 patients (266 renal lesions) who underwent a clinically indicated PVP abdominopelvic CT on a rapid-kilovoltage-switching single-source DECT (rsDECT) or a dual-source DECT (dsDECT) scanner. Iodine concentration and HU measurements were calculated by four experienced readers. Diagnostic accuracy was determined using biopsy results and foll...
Source: European Radiology - June 11, 2021 Category: Radiology Source Type: research

Five-star rating system for acceptable quality and dose in CT
Key Points•Recent papers have shown examples of the methodology involved in integrating image quality with radiation dose and assessing acceptable quality dose (AQD).•As a further step in that direction, translating a 5-point score into a 5-star rating shall be helpful for wider and uniform application and shall be in line with the popular use of the 5-star rating. (Source: European Radiology)
Source: European Radiology - June 11, 2021 Category: Radiology Source Type: research