CT measures of femoral and tibial version and rotational position of femoral and tibial components of knee replacements: limitations in reliability and suitability for routine clinical practice
ConclusionThe lower 95% confidence level for ICC of version and rotational measurements using the Berger protocol of TKRs on CT are all less than 0.73 and that the normal range of differences between observers is up to 9 ° for the femoral component and 26° for the tibial component. This suggests that CT measurements derived from the Berger protocol may not be consistent enough for clinical practice.Key Points•CT is commonly used to measure the rotational profile of knee replacements in symptomatic patients using the Berger protocol.•The limits of agreement for both femoral and tibial component rotation are wide even ...
Source: European Radiology - February 10, 2022 Category: Radiology Source Type: research

Identification of the suitable candidates for EOB-MRI with the high risk of the presence of non-hypervascular hypointense nodules in patients with HCV infection
ConclusionsM2BPGi is a serum marker that potentially identifies HCV patients with high risk of the presence of NHHNs, for whom EOB-MRI should be considered.Key Points•Non-hypervascular hypointense nodule on EOB-DTPA-enhanced MRI is pre-HCC nodule with high likelihood of progressing to HCC, which is a strong predictor for HCC that develops after the eradication of HCV in patients with HCV infection.•It is difficult for all patients with HCV infection to undergo EOB-MRI for NHHN detection due to limited access, limited availability of MRI equipment, and high costs.•Serum Wisteria floribunda agglutinin –positive Mac-2...
Source: European Radiology - February 10, 2022 Category: Radiology Source Type: research

Differences in the prognostic implication of ground-glass opacity on CT according to pathological nodal status in lung cancers treated with lobectomy or pneumonectomy
ConclusionsGGO was a favorable predictor of survival only in patients with pN0 category, showing an advantage in DFS for those with cT1 category and OS for those with cT1/2 category.Key Points•The presence of ground-glass opacity was associated with a favorable prognosis, only in pathological node-negative patients (5-year disease-free survival, p = .002; 5-year overall survival, p = .002).•Within pathological node-negative patients, the effect of ground-glass opacity on 5-year disease-free survival was valid in patients with cT1 category (adjusted hazard ratio, 0.48; 95% confidence interval, 0.32 –0.72; p< .001),...
Source: European Radiology - February 10, 2022 Category: Radiology Source Type: research

Polycystic liver: automatic segmentation using deep learning on CT is faster and as accurate compared to manual segmentation
ConclusionCompared with manual segmentation, automated segmentation of polycystic livers using a deep learning method achieved much faster segmentation with similar performance.Key Points•Automatic volumetry of polycystic livers using artificial intelligence method allows much faster segmentation than expert manual segmentation with similar performance.•No statistical difference was observed between automatic segmentation, inter-observer variability, or intra-observer variability. (Source: European Radiology)
Source: European Radiology - February 10, 2022 Category: Radiology Source Type: research

Quantitative MR evaluation of the infrapatellar fat pad for knee osteoarthritis: using proton density fat fraction and T2* relaxation based on DIXON
ConclusionsFF and T2* alternations in IFP are associated with knee structural abnormalities and clinical symptoms cross-sectionally and may have the potential to predict the severity of KOA.Key Points• Fat fraction (FF) and T2* relaxation based on DIXON imaging are novel methods to quantitatively assess the infrapatellar fat pad for knee osteoarthritis (KOA) progression in older adults.• The alterations of FF and T2* using mDIXON technique in IFP were associated with knee structural abnormalities and clinical symptoms.• FF and T2* alternations in IFP can serve as the new imaging biomarkers for fast, simple, and nonin...
Source: European Radiology - February 9, 2022 Category: Radiology Source Type: research

A fully automatic multiparametric radiomics model for differentiation of adult pilocytic astrocytomas from glioblastomas
ConclusionsThe fully automatic combined clinical and radiomics model may be helpful for differentiating adult PAs from HGGs.Key Points•Differentiating adult PAs from HGGs is challenging because PAs may manifest a large spectrum of imaging presentations, often including aggressive imaging features.•The fully automatic combined clinical and radiomics model showed a significantly higher performance than the clinical model or humans.•The model explanation by SHAP suggested that second-order features from T2-weighted imaging were important in diagnosis and might reflect the underlying pathophysiology that PAs have lesser ...
Source: European Radiology - February 9, 2022 Category: Radiology Source Type: research

A diagnostic index based on quantitative susceptibility mapping and voxel-based morphometry may improve early diagnosis of Alzheimer ’s disease
ConclusionsIn this preliminary study, the proposed index based on QSM and VBM improved the diagnostic performance between MCI and NC groups compared with the VBM-based index.Key Points•We developed a novel diagnostic index for Alzheimer ’s disease based on quantitative susceptibility mapping (QSM) and voxel-based morphometry (VBM).•QSM and VBM images can be acquired simultaneously in a single sequence with little increasing scan time.•In this preliminary study, the proposed diagnostic index improved the discriminative performance between mild cognitive impairment and normal control groups compared with the conventi...
Source: European Radiology - February 8, 2022 Category: Radiology Source Type: research

A nomogram strategy for identifying the subclassification of IDH mutation and ATRX expression loss in lower-grade gliomas
ConclusionsThe nomogram incorporating age, gender, and the radiomics signature provided a clinically useful approach in noninvasively predicting IDH and ATRX mutation status for LrGG patients. The proposed method could facilitate MRI-based clinical decision-making for the LrGG patients.Key Points•Non-invasive determination of IDH and ATRXgene status of LrGG patients can be obtained with a radiomics nomogram.•The proposed nomogram is constructed by radiomics signature selected from 250 radiomics features, combined with age and gender.•The proposed radiomics nomogram exhibited good calibration and discrimination for ID...
Source: European Radiology - February 8, 2022 Category: Radiology Source Type: research

Embolization in pelvic venous disorders using ethylene vinyl alcohol copolymer (Onyx ®) and Aetoxysclerol: a prospective evaluation of safety and long-term efficacy
ConclusionEmbolization using Onyx® and Aetoxysclerol for PeVD is safe and effective.Key Points• Embolization using Onyx®and Aetoxysclerol for pelvic venous disorders is safe and effective.• Imaging follow-up is facilitated by visualization of Onyx®on MRI DIXON sequences. (Source: European Radiology)
Source: European Radiology - February 8, 2022 Category: Radiology Source Type: research

SUVmax to tumor perimeter distance: a robust radiomics prognostic biomarker in resectable non-small cell lung cancer patients
ConclusionThe geometric variables, nSCD and nSPD, are robust biomarkers of the poorest outcome prediction of patients with NSCLC with respect to classical PET variables.Key Points•In NSCLC patients, it is crucial to find prognostic parameters since  TNM system alone cannot explain the variation in lung cancer survival.•Age, lymphovascular invasion, lymph nodal infiltration, and metabolic geometrical parameters were useful as prognostic parameters.•The displacement grade of the highest point of metabolic activity towards the periphery assessed by geometric variables obtained from [18F]FDG  PET/CT was a robust biomar...
Source: European Radiology - February 8, 2022 Category: Radiology Source Type: research

Outcomes after primary and repeat thermal ablation of hepatocellular carcinoma with or without liver transplantation
ConclusionsWe found TA to be an effective and repeatable therapy for primary and recurrent HCC. Most recurrences can be treated with curative intent. There are patients who do well with TA alone without ever undergoing OLTx.Key Points•Recurrent HCC after primary TA can often be treated effectively with repeat TA. Survival after repeat TA is comparable to primary TA.•In matched cohorts, outcomes after TA with and without subsequent waitlisting for OLTx are comparable.•There are patients who do well for many years with primary and repeat TA alone; some despite multiple recurrences. (Source: European Radiology)
Source: European Radiology - February 8, 2022 Category: Radiology Source Type: research

DCE-MRI based radiomics nomogram for preoperatively differentiating combined hepatocellular-cholangiocarcinoma from mass-forming intrahepatic cholangiocarcinoma
ConclusionThe radiomics nomogram based on DCE-MRI may provide an effective and noninvasive tool to differentiate cHCC-CC from IMCC, which could help guide treatment strategies.Key Points•The radiomics signature based on dynamic contrast-enhanced magnetic resonance imaging is useful to preoperatively differentiate cHCC-CC from IMCC.•The radiomics nomogram showed the best performance in both training and validation cohorts for differentiating cHCC-CC from IMCC. (Source: European Radiology)
Source: European Radiology - February 7, 2022 Category: Radiology Source Type: research

CT imaging findings of renal epithelioid lipid-poor angiomyolipoma
ConclusionWe identified specific CT imaging features and predictors that could contribute to the correct diagnosis of E-lpAML. Our findings should be helpful for clinical management of E-lpAML which could potentially be malignant and may require nephron-sparing surgery while other lpAML tumors which are benign require no intervention.Key Points•It is important to differentiate renal epithelioid lipid-poor angiomyolipoma (E-lpAML) from other lpAML because of differences in clinical management.•E-lpAML tumors tend to be large hyperdense tumors in the renal sinus with cystic degeneration and “fast-in and slow-out” pat...
Source: European Radiology - February 6, 2022 Category: Radiology Source Type: research

The changing trends of image-guided biopsy of small renal masses before intervention —an analysis of European multinational prospective EuRECA registry
ConclusionAn increased use of pre-cryoablation biopsy was observed and cryoablation patients treated with a benign histology are more likely to have presented in periods where pre-cryoablation biopsy is not as prevalent. Comparative studies are needed to draw definitive conclusions on the effect of pre-cryoablation biopsy on SRM treatments.Key Points•The use of biopsy pre-ablation session has increased significantly from 42% of all patients in 2015 to 74% in 2019.•Patients are less likely to be treated for a benign tumour if they presented later in the trend, where pre-cryoablation biopsy is more prevalent, compared to...
Source: European Radiology - February 5, 2022 Category: Radiology Source Type: research

Individualized arterial spin labeling background suppression by rapid T1 mapping during acquisition
ConclusionThe individually optimized background suppression pulses improve the image appearance and allow for a better visualization of cortical structures. The proposed technique however prolongs scan time, which can be seen as negative result, yet needs to be further evaluated.Key Points•Background suppression timing in ASL can vary.•Both the label and control condition can be modified for T1 mapping.•Adapting the pulse timing improves the signal-to-background ratio. (Source: European Radiology)
Source: European Radiology - February 4, 2022 Category: Radiology Source Type: research