F-Actin is Associated with a Worsening qSOFA Score and Intensive Care Unit Admission in Emergency Department Patients at Risk for Sepsis.
CONCLUSION: Increased levels of plasma F-actin measured in the ED were associated with incremental illness severity as measured by the qSOFA score and need for ICU admission. F-actin may have utility in risk stratification of undifferentiated patients in the ED presenting with signs and symptoms of sepsis. PMID: 32421363 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - May 20, 2020 Category: Research Tags: Biomarkers Source Type: research

A systematic review and meta-analysis of higher expression of Folate receptor alpha (FOLR1) predicts poor cancer prognosis.
Authors: Liu Y, Lian T, Yao Y Abstract Folate Receptor Alpha (FOLR1), a glycosylphosphatidylinositol-linked protein, is well characterized folate transporters. However, the prognostic power of FOLR1 in cancer remains controversial. We conducted a meta-analysis to assess the prognostic roles of FOLR1 on different cancers. 12 studies involving 4,471 patients were included in this meta-analysis. The pooled analysis indicated that high FOLR1 significantly predicted poor overall survival (OS) [pooled hazard ratio (HR) =0.78, 95% confidence interval (CI) =0.64-0.94, P = 0.009] and the disease-free survival ...
Source: Biomarkers - May 20, 2020 Category: Research Tags: Biomarkers Source Type: research

Comparison of temporal changes in established cardiovascular biomarkers after acute coronary syndrome between Caucasian and Chinese patients with diabetes mellitus.
In this study we performed detailed comparisons in the temporal pattern of these biomarkers between Caucasian and Chinese diabetic patients with acute coronary syndrome (ACS).Methods: We studied differences in temporal changes of established cardiovascular biomarkers, including high-density lipoprotein (HDL), low-density lipoprotein (LDL), total cholesterol, cardiac Troponin T (TnT), NT-proBNP and C-reactive protein (CRP), in 48 Chinese and 48 clinically matched Caucasian patients with type 2 diabetes mellitus who were admitted for ACS. Blood samples were collected at regular time intervals during 30 days to 1&thins...
Source: Biomarkers - May 7, 2020 Category: Research Tags: Biomarkers Source Type: research

Application of the Fourth Universal Definition of Myocardial Infarction in Clinical Practice.
Conclusions: Type 1 MI is a consequence of coronary plaque rupture or erosion with intracoronary thrombus formation that is usually apparent on coronary angiography. Plausible triggering mechanisms causing myocardial oxygen supply/demand mismatch must be identified for the diagnosis of type 2 MI and its treatment should focus initially on management of the underlying disease attributable to acute myocardial ischemia. PMID: 32362195 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - May 5, 2020 Category: Research Tags: Biomarkers Source Type: research

Role of Ascitic Endocan Levels in the Diagnosis of Spontaneous Bacterial Peritonitis in Decompensated Cirrhosis.
Authors: Wu X, Luo J, Huang W, Jia B, Luo T Abstract Objective To assess the role of ascitic endocan levels in the diagnosis of spontaneous bacterial peritonitis (SBP) in decompensated cirrhosis.Methods Ascites samples, as well as demographic and laboratory data, were collected at admission from patients with decompensated cirrhosis. Ascitic endocan, tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) levels were measured by ELISA. The influencing factors of SBP, the correlation of ascitic endocan with other inflammatory indicators, and the diagnostic value of ascitic endocan for SBP were analyzed...
Source: Biomarkers - May 5, 2020 Category: Research Tags: Biomarkers Source Type: research

Management of Citrus sinensis peels for protection and treatment against gastric ulcer induced by ethanol in rats.
Conclusion: C. sinensis petroleum ether peels extract had protective and curative effects against gastric ulcer. Therefore, the extract recorded anti-secretory, anti-ulcerative, anti-inflammatory, and antioxidant effects. Its healing action exceeded its protective role due to its richness in polymethoxylated flavonoids. PMID: 32319821 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - April 24, 2020 Category: Research Tags: Biomarkers Source Type: research

Biomarker dynamics in cardiac surgery: a prospective observational study on MR-proADM, MR-proANP, hs-CRP and sP-selectin plasma levels in the perioperative period.
Conclusions: The findings in this study may help to understand the physiology of the biomarkers analysed and their response to cardiac surgical trauma including CPB. Furthermore, these findings will guide us in further research on the clinical usefulness of these biomarkers. PMID: 32301345 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - April 18, 2020 Category: Research Tags: Biomarkers Source Type: research

Analysis of CYP450 gene allelic variants can predict ifosfamide toxicity in Mexican paediatric patients.
Conclusions: Our results show that allelic variants rs3745274 (CYP2B6), rs2740574 (CYP34) and rs776746 (CYP3A5) increase the risk for high haematological toxicity.Clinical trial registration: 068/2013. PMID: 32279544 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - April 15, 2020 Category: Research Tags: Biomarkers Source Type: research

Alterations of lymphocyte count and platelet volume precede cerebrovascular lesions in stroke-prone spontaneously hypertensive rats.
Conclusion: Our pilot study suggests that alterations of lymphocyte count and platelet volume predictive indicators for asymptomatic CSVD and symptomatic stroke in SHRSP. PMID: 32285702 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - April 15, 2020 Category: Research Tags: Biomarkers Source Type: research

Expression of Concern.
Authors: PMID: 32274940 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - April 11, 2020 Category: Research Tags: Biomarkers Source Type: research

Usefulness of F2-isoprostanes in early prognostication after cardiac arrest: A topical review of the literature and meta-analysis of preclinical data.
Authors: Karlis G, Kotanidou A, Georgiopoulos G, Masi S, Magkas N, Theodoros X Abstract Prognostication after cardiac arrest (CA) represents a challenging issue, and several biomarkers have been proposed in the attempt to predict outcome. Among these, F2-isoprostanes stand out as potential biomarkers for early prognostication, providing information on the magnitude of global oxidative injury after return of spontaneous circulation (ROSC). We performed a topical review searching PubMed and Scopus databases to identify studies evaluating the modifications of F2-isoprostanes in the early period after CA, and a meta-an...
Source: Biomarkers - April 11, 2020 Category: Research Tags: Biomarkers Source Type: research

SPARCL1 as a biomarker of maladaptive right ventricular remodelling in pulmonary hypertension.
This study assessed the utility of SPARC-like protein 1 (SPARCL1) as a biomarker of maladaptive right ventricular (RV) function in patients with pulmonary hypertension (PH).Methods: In this prospective study, we examined SPARCL1 levels in 105 patients with adaptive (n = 34) and maladaptive RV (n = 32) pressure overload caused by PH, dilated cardiomyopathy (DCM, n = 18) with LVEF
Source: Biomarkers - April 8, 2020 Category: Research Tags: Biomarkers Source Type: research

Expression of Concern.
Authors: PMID: 32253935 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - April 8, 2020 Category: Research Tags: Biomarkers Source Type: research

Expression of Concern.
Authors: PMID: 32253939 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - April 8, 2020 Category: Research Tags: Biomarkers Source Type: research

Association between red blood cell distribution width and long-term mortality among patients undergoing percutaneous coronary intervention with previous history of cancer.
Authors: Yang QY, Li XF, Lin MQ, Xu JH, Yan H, Zhang ZM, Wang SY, Chen HC, Chen XN, Lin KY, Guo YS Abstract Background: The number of patients suffering from coronary heart disease with cancer is rising. There is scarce evidence concerning the biomarkers related to prognosis among patients undergoing percutaneous coronary intervention (PCI) with cancer. Thus, the aim of this study was to investigate the association between red blood cell distribution width (RDW) and prognosis in this population.Methods: A total of 172 patients undergoing PCI with previous history of cancer were enrolled in this retrospective study....
Source: Biomarkers - March 8, 2020 Category: Research Tags: Biomarkers Source Type: research

Diagnostic utility of MR-proANP and NT-proBNP in elderly outpatients with a high risk of heart failure: the Copenhagen heart failure risk study.
This study sought to assess the diagnostic utility of MR-proANP in outpatients with a high risk of HF.Methods: This prospective study included 399 outpatients. Inclusion criteria were: age ≥ 60 years, ≥1 risk factor for HF (diabetes, chronic kidney disease, vascular disease, atrial fibrillation, hypertension), without known or suspected HF. Unrecognized HF was diagnosed based on clinical signs, patient-reported symptoms and echocardiography. Plasma concentrations of MR-proANP and NT-proBNP were analysed.Results: In total, 65 patients were diagnosed with HF or asymptomatic left ventricular systoli...
Source: Biomarkers - March 6, 2020 Category: Research Tags: Biomarkers Source Type: research

Plasma levels of Nesfatin-1 as a New Biomarker in Depression in Asians: Evidence from Meta-analysis.
This study aims to review the alteration of plasma nesfatin-1 levels in patients with depression.Methods: Under the guidance of the latest PRISMA checklist, a systematic review and meta-analysis were conducted by searching English database (PubMed, Web of Science, EMDASE)and Chinese database for relevant studies up to August, 2019. Pooled standardized mean difference (SMD) with 95% confidence intervals (CI) was calculated with the random effects model.Results: Nine studies that reported the association between plasma levels of nesfatin-1 and the risk of depression with 567 patients and 447 control participants were include...
Source: Biomarkers - March 4, 2020 Category: Research Tags: Biomarkers Source Type: research

Protective Effect of Rosemary (Rosmarinus officinalis) Against Diethylnitrosamine-Induced Renal Injury in Rats.
Conclusion: Rosemary (powder/E.O) was able to reduce or even prevent the severity of diethylnitrosamine-induced renal dysfunction. PMID: 32118487 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - March 4, 2020 Category: Research Tags: Biomarkers Source Type: research

Blood biomarkers for assessment of mild traumatic brain injury and chronic traumatic encephalopathy.
Authors: Hiskens MI, Schneiders AG, Angoa-Pérez M, Vella RK, Fenning AS Abstract Mild traumatic brain injuries (mTBI) are prevalent and can result in significant debilitation. Current diagnostic methods have implicit limitations, with clinical assessment tools reliant on subjective self-reported symptoms or non-specific clinical observations, and commonly available imaging techniques lacking sufficient sensitivity to detect mTBI. A blood biomarker would provide a readily accessible detector of mTBI to meet the current measurement gap. Suitable options would provide objective and quantifiable information in d...
Source: Biomarkers - February 27, 2020 Category: Research Tags: Biomarkers Source Type: research

Dynamic thiol/disulfide homeostasis as indicator of oxidative stress in automotive workers.
Authors: Büyükşekerci M, Gündüzöz M, Özakıncı G, Karataş M, Şenat A, Neşelioğlu S, Erel Ö Abstract Purpose: To examine thiol-disulfide homeostasis auto paintersMaterials and methods: A total of 115 male workers, including 60 auto painters workers and 55 reference group, of the painting and assembly line units respectively, were included in the study. Thiol-disulfide parameters and ischemia-modified albumin (IMA) of groups were determined. Urinary hippuric acid, (HA) phenol, hexanedione, trichloroacetic acid, arsenic and blood lead and manganese were analyzed.Results: The me...
Source: Biomarkers - February 25, 2020 Category: Research Tags: Biomarkers Source Type: research

The prognostic impact of tumour NSD2 expression in advanced prostate cancer.
CONCLUSION: NSD2 expression is abnormal in almost 80% of patients with advanced PCa. Expression levels of this epigenetic regulator are easily detected by immunohistochemistry while this biomarker exhibited prognostic value for PCa progression and death in univariable analysis. Further studies on NSD2 involvement in PCa proliferation, progression, metastasis and resistance mechanisms are needed. PMID: 32091270 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - February 25, 2020 Category: Research Tags: Biomarkers Source Type: research

Enhanced clinical phenotyping by mechanistic bioprofiling in heart failure with preserved ejection fraction: insights from the MEDIA-DHF study (The Metabolic Road to Diastolic Heart Failure).
Conclusion: Unsupervised machine-learning algorithms applied to a wide range of biomarkers identified 2 HFpEF clusters with different CV phenotypes and outcomes. The identified pathways may provide a basis for future research.Clinical significanceMore insight is obtained in the mechanisms related to poor outcome in HFpEF patients since it was demonstrated that biomarkers associated with the high-risk cluster were related to the immune system, signal transduction cascades, cell interactions and metabolismBiomarkers (and pathways) identified in this study may help select high-risk HFpEF patients which could be helpful for th...
Source: Biomarkers - February 20, 2020 Category: Research Tags: Biomarkers Source Type: research

Prognostic value of pretreatment red blood cell distribution width in lung cancer: a meta-analysis.
Authors: Wang Y, Zhou Y, Zhou K, Li J, Che G Abstract Objective In recent years, increasing studies found that pretreatment red blood cell distribution width (RDW) could predict clinical outcomes in various cancers. However, the prognostic value of pretreatment RDW in lung cancer was inconsistent. Therefore, we performed a meta-analysis to determine prognostic value of pretreatment RDW in lung cancer.Methods We performed a search in PubMed, The Cochrane Library, EMBASE (via OVID), Web of Science, CNKI, Wanfang, VIP, SinoMed databases, then we identified all records up to February 15, 2019. Outcomes of interest were...
Source: Biomarkers - February 20, 2020 Category: Research Tags: Biomarkers Source Type: research

High-Frequency Metabolite Profiling and the Incidence of Recurrent Cardiac Events in Post-Acute Coronary Syndrome Patients.
Authors: Vroegindewey MM, van den Berg VJ, Oemrawsingh RM, Kardys I, Asselbergs FW, van der Harst P, Kietselaer B, Lenderink T, Akkerhuis KM, Boersma E Abstract Purpose To study temporal changes in metabolite profiles in post-acute coronary syndrome (ACS) patients, in particular prior to the development of recurrent ACS (reACS).Methods BIOMArCS is a prospective study including patients admitted for ACS, who underwent high-frequency blood sampling during 1 year follow-up. Within BIOMArCS, we performed a nested case-cohort analysis of 158 patients (28 cases of reACS). We determined 151 metabolites by nuclear magnetic...
Source: Biomarkers - February 20, 2020 Category: Research Tags: Biomarkers Source Type: research

Relationship between autoantibodies to erythropoietin receptor and renal outcome in patients with anti-neutrophil cytoplasmic antibody-associated vasculitis.
Conclusion: Anti-EPOR antibodies were associated with the progression of renal dysfunction in patients with AAV. PMID: 32024392 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - February 8, 2020 Category: Research Tags: Biomarkers Source Type: research

Elevated CEA and CA19-9 serum levels independently predict advanced pancreatic cancer at diagnosis.
Conclusion: CEA appears to be a more robust predictor of advanced PDAC than CA19-9. Implementing CEA and CA19-9 serum levels during MDT meetings as additional tool for establishing tumor resectability is worthwhile for tailored diagnostics. PMID: 32009482 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - February 5, 2020 Category: Research Tags: Biomarkers Source Type: research

Diagnosis of acute intoxications in critically ill patients: Focus on biomarkers - Part 2: Markers for specific intoxications.
Authors: Reisinger A, Rabensteiner J, Hackl G Abstract In medical intensive care units acute intoxications contribute for a large proportion of all patients. Epidemiology and a basic overview on this topic were presented in part one. The purpose of this second part regarding toxicological biomarkers in the ICU setting focuses on specific poisons and toxins. Following the introduction of anion and osmol gap in part one, it's relevance in toxic alcohols and other biomarkers for these poisonings are presented within this publication. Furthermore, the role of markers in the blood, urine and cerebrospinal fluid for seve...
Source: Biomarkers - February 5, 2020 Category: Research Tags: Biomarkers Source Type: research

Occupational low-level exposure to hard metals: cobalt and tungsten biomonitoring as an effective tool to evaluate the effectiveness of industrial hygiene interventions for risk management.
Conclusions: Biological monitoring of Co and W in the hard metal tools manufacturing industry is a sensitive and effective method to evaluate the effectiveness of prevention practices. PMID: 31996048 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - February 1, 2020 Category: Research Tags: Biomarkers Source Type: research

Predictive value of metabolomic biomarkers for cardiovascular disease risk: a systematic review and meta-analysis.
CONCLUSION: This study provides evidence that metabolomic biomarkers, mainly lipid species, have the potential to provide additional prognostic value. Current data are promising, although approaches and results are heterogeneous. PMID: 31928240 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - January 15, 2020 Category: Research Tags: Biomarkers Source Type: research

Pre-procedural Elevated Cardiac Troponin Predict Risk of Long-term All-cause Mortality after Transcatheter Aortic Valve Replacement: A Meta-Analysis of Prospective Studies.
Authors: Li Y, Pei H, Zhou C, Lou Y Abstract Background: The purpose of this meta-analysis was to evaluate the relationship between elevated cardiac troponin pre- transcatheter aortic valve replacement (TAVR) and long-term all-cause mortality.Methods: Prospective studies with the endpoint of all-cause mortality were included. We primarily used the fixed-effect model weighted by inverse variance. Meta-regression and subgroup analyses were conducted to explore the potential sources of heterogeneity by specified study characteristics.Results: Seven prospective studies comprising of 3049 subjects were included in our m...
Source: Biomarkers - January 12, 2020 Category: Research Tags: Biomarkers Source Type: research

A specific autoantibody against a novel tumor-association antigen derived from human DNA-topoiomerase I is a potential biomarker for early diagnosis and favorable prognosis in patients with colorectal carcinoma.
Conclusion-The autoantibody is a potential biomarker for early diagnosis and favorable prognosis of CRC. PMID: 31922440 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - January 12, 2020 Category: Research Tags: Biomarkers Source Type: research

Diagnostic value of GLUT-1 in distinguishing malignant mesothelioma from reactive mesothelial cells: A meta-analysis.
Conclusions: GLUT-1 is highly accurate to distinguish malignant mesothelioma from reactive mesothelial cells. PMID: 31916460 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - January 11, 2020 Category: Research Tags: Biomarkers Source Type: research

Subjects with microvascular angina have longer GT repeats polymorphism in the heme oxygenase-1 gene promoter.
Authors: Liang KW, Lee WJ, Lee IT, Lee WL, Wang JS, Wu JP, Sheu WH Abstract Objective: Few studies have investigated heme oxygenase-1 gene (HMOX1) promoter polymorphism in microvascular angina (MVA).Materials and methods: HMOX1 promoter (GT)n repeats were examined in healthy controls (N = 220) and MVA subjects (N = 181).Results: The distribution of genotype of SS, SL and LL were significantly different in MVA (17%, 51%, 33%) vs. normal controls (35%, 46%, 20%) (p  30 repeats). In multivariate analysis, carrier of L allele (odds ratio 2.772, p 
Source: Biomarkers - January 11, 2020 Category: Research Tags: Biomarkers Source Type: research

Investigating the role of T helper related cytokines in cerebrospinal fluid for the differential diagnosis of bacterial meningitis in pretreated pediatric patients.
CONCLUSION: In pretreated BM patients with negative bacterial cultures, cytokines IL-6, IL-10 and IFN-γ can predict BM which could be beneficial for rapid diagnosis and treatment to decrease the sequela of the disease. PMID: 31916867 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - January 11, 2020 Category: Research Tags: Biomarkers Source Type: research

Biomarkers in patients with Takotsubo cardiomyopathy compared to patients with acute anterior ST-elevation myocardial infarction.
Authors: Højagergaard MA, Hassager C, Christensen TE, Bang LE, Gøtze JP, Ostrowski SR, Holmvang L, Frydland M Abstract Background: Takotsubo cardiomyopathy (TTC) is a syndrome of acute non-coronary heart failure with similar symptoms and electrocardiograms to acute anterior ST-elevation myocardial infarction (STEMI). Little is known about the pathophysiology of TTC. We assessed admission plasma concentrations of biomarkers reflecting neuroendocrine response (copeptin, mid-regional-pro-adrenomedullin, pro-atrial-natriuretic-peptide, soluble thrombomodulin (sTM), syndecan-1) and inflammation (suppressio...
Source: Biomarkers - January 8, 2020 Category: Research Tags: Biomarkers Source Type: research

Biomarker-Specific Differences Between Transpulmonary and Peripheral Arterial-Venous Blood Sampling in Patients with Pulmonary Hypertension.
Authors: Meoli DF, Clark DE, Davogustto G, Su YR, Brittain EL, Hemnes AR, Monahan K Abstract PURPOSE: Transpulmonary biomarkers may provide insight into pulmonary hypertension (PH) pathophysiology, but require cardiac catheterization. We investigated whether the peripheral arterial/venous ratio (PR) could substitute for the transpulmonary ratio (TPR). MATERIALS AND METHODS: Blood from the pulmonary artery (PA), pulmonary arterial wedge (PAW), peripheral venous, and peripheral arterial positions was analyzed for ET-1, NT-pro-BNP, and cAMP levels in subjects with no PH (n = 18) and PH due to left he...
Source: Biomarkers - January 8, 2020 Category: Research Tags: Biomarkers Source Type: research

Association between smoking status and homocysteine levels and possible effect modification by cholesterol and estradiol.
Conclusion: Homocysteine levels did differ across smoking status after adjusting for confounders. Estradiol did moderate the relationship between homocysteine and smoking status. PMID: 31835911 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - December 16, 2019 Category: Research Tags: Biomarkers Source Type: research

Impact of betanin against paracetamol and diclofenac induced hepato-renal damage in rats.
Conclusion: Bet exerted a potential anti-inflammatory and antioxidant effect against hepato-renal damage induced by PAR or DF overconsumption. PMID: 31766895 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - November 28, 2019 Category: Research Tags: Biomarkers Source Type: research

The progressive alteration of urine metabolomic profiles of rats following long-term and low-dose exposure to permethrin.
Conclusion: The time-course alteration of metabolomic profiles of the urine based on 1H NMR reflects the progressive development of the chronic toxicity with the long-term low-level exposure of permethrin.SIGNIFICANCEUrine metabolomic profiles of rats treated with permethrin were characterized by 1H NMR spectrometry. The exposure of permethrin at its low dose (1/20 LD50) can cause significant and progressive changes in the urine metabolites although no change was found in serum clinical biochemistry. The metabolite changes reflect the progression of the toxicity following long-term exposure to permethrin. The changed urine...
Source: Biomarkers - November 26, 2019 Category: Research Tags: Biomarkers Source Type: research

Clinicopathologic features and prognostic significance of CD30 expression in de novo diffuse large B-cell lymphoma (DLBCL): results in a homogeneous series from a single institution.
Authors: Salas MQ, Climent F, Tapia G, DomingoDomènech E, Mercadal S, Oliveira AC, Aguilera C, Olga G, Moreno Velázquez M, Andrade-Campos M, Encuentra M, Fernández de Sevilla A, Sureda A, Sancho JM, González-Barca E Abstract Introduction: The present study evaluates CD30 expression by immunohistochemistry (IHQ) in 216 patients with de novo DLBCL.Methods: CD30 expression was assessed retrospectively in all cases by IHQ. More than>0% and>20% of CD30 expression in the malignant cells were used as a cut-off for positivity. Survival was analysed in 176 patients treated with R-CHOP/R-CHO...
Source: Biomarkers - November 23, 2019 Category: Research Tags: Biomarkers Source Type: research

Diagnosis of acute intoxications in critically ill patients: Focus on biomarkers - Part 1: Epidemiology, methodology and general overview.
Authors: Reisinger A, Rabensteiner J, Hackl G Abstract Acute intoxications account for a significant proportion of the patient population in intensive care units and sedative medications, ethanol, illicit drugs, inhalable poisons and mixed intoxications are the most common causes. The aim of this article is to describe biomarkers for screening and diagnosis of acute intoxications in critically ill patients. For this purpose, a survey of the relevant literature was conducted, and guidelines, case reports, expert assessments, and scientific publications were reviewed. In critical care it should always be attempted to...
Source: Biomarkers - November 19, 2019 Category: Research Tags: Biomarkers Source Type: research

Circulating microRNA as biomarkers of clozapine-induced cardiotoxicity.
CONCLUSIONS: Plasma miRNA are not useful biomarkers of CLZ-induced cardiotoxicity, however patients taking CLZ have significantly altered circulating miRNA compared to healthy volunteers. PMID: 31722571 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - November 16, 2019 Category: Research Tags: Biomarkers Source Type: research

Gastroprotective effect of leaf extract of two varieties grapevine (Vitis vinifera L.) native wild and cultivar grown in North of Tunisia against the oxidative stress induced by ethanol in rats.
Conclusion: The leaves of Vitis species might be suitable as a functional food for therapeutic purpose and demonstrates gastroprotective action in gastric lesions model. Both accessions exhibited gastroprotective effects, but wild "Nefza-I" ecotype was more effective than cultivar "Marsaoui". PMID: 31714159 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - November 13, 2019 Category: Research Tags: Biomarkers Source Type: research

Tissue-based miRNA mapping in alcoholic liver cirrhosis: different profiles in cirrhosis with or without hepatocellular carcinoma.
Conclusion: We were able to show for the first time, the differences of miRNA profile as promising biomarker in HCC, tumour-associated cirrhosis, and cirrhosis without HCC in context of alcoholic liver disease. PMID: 31701763 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - November 10, 2019 Category: Research Tags: Biomarkers Source Type: research

Role of Glial Fibrillary Acidic protein as a biomarker in differentiating intracerebral hemorrhage from ischemic stroke and stroke mimics: A meta-analysis.
Conclusion: Our meta-analysis suggests that GFAP has a promising diagnostic accuracy for the differentiation of ICH from IS and mimics. Further, phase II and phase III diagnostic test studies are required to validate the findings before using GFAP as a blood based biomarker for clinical use.Trial Registration: This study was registered in OSF registries 10.17605/OSF.IO/B9JP4. PMID: 31702405 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - November 10, 2019 Category: Research Tags: Biomarkers Source Type: research

Early serum cystatin C enhanced risk prediction for acute kidney injury post cardiac surgery: a prospective, observational, cohort study.
Conclusions: AKI following cardiac surgery was identified using KDIGO criteria in around one fourth of the patients. These patients had significantly increased morbidity and mortality. When added to prediction model, 10h sCyC may enhance the identification of patients at higher risk of AKI, providing a readily available prognostic marker. PMID: 31686541 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - November 8, 2019 Category: Research Tags: Biomarkers Source Type: research

Nicotine metabolite ratios in serum and urine among US adults: Variations across smoking status, gender and race/ethnicity.
The objective of this study was to evaluate factors affecting variabilities in the observed levels of nicotine metabolite ratios in serum (NMRS, N = 10234) and urine (NMRU, N = 2286) for US adults aged> = 20 years.Materials and methods: Data from NHANES were used to fit regression models for log10 transformed values of NMRS and NMRU stratified by gender and smoking status.Results: Females had higher NMRS than males among both smokers and nonsmokers. Females had lower NMRU than males among both smokers and nonsmokers. Smokers had lower levels of both NMRS and NMRU among both males and f...
Source: Biomarkers - November 8, 2019 Category: Research Tags: Biomarkers Source Type: research

Is Engrailed-2 (EN2) a truly promising biomarker in prostate cancer detection?
Conclusions: Our results show that EN2 as a PC biomarker brings no additional value to the current use of PSA in clinical practice. PMID: 31692391 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - November 8, 2019 Category: Research Tags: Biomarkers Source Type: research

New potential modulators of CYP4F2 enzyme activity in angina pectoris: hsa-miR-24-3p and hsa-miR-34a-5p.
Conclusions. Our data suggests that hsa-miR-24-3p might have an effect on CYP4F2 activity during atherosclerosis. PMID: 31694408 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - November 8, 2019 Category: Research Tags: Biomarkers Source Type: research

Tumor necros ıs factor lıke cytokıne 1A levels and lesıon complexıty ın non-smokıng patıents wıth coronary artery dısease.
Tumor necrosıs factor lıke cytokıne 1A levels and lesıon complexıty ın non-smokıng patıents wıth coronary artery dısease. Biomarkers. 2019 Oct 24;:1-19 Authors: Akyüz A, Özkaramanlı Gür D, Alpsoy Ş, Güzel S Abstract Background: Tumor necrosis factor like cytokine 1A (TL1A), which is a member of tumor necrosis factor alpha superfamily (TNF-α), is a novel indicator of atherosclerosis. Objective: Smoking is an established stimulant of TNF-α. We aimed to investigate whether TLA1 plays a role in the presence and complexity of coronary artery atherosclerosis, exclu...
Source: Biomarkers - October 26, 2019 Category: Research Tags: Biomarkers Source Type: research