Protective effect of argan oil on DNA damage < em > in  vivo < /em > and < em > in  vitro < /em >
Conclusion: We found a striking effect of AO by ameliorating DNA damage after iron overload in a mouse liver model and in human fibroblasts by hyperoxia adding compelling evidence to the protective mechanisms of AO and OO.PMID:33843382 | DOI:10.1080/1354750X.2021.1905068 (Source: Biomarkers)
Source: Biomarkers - April 12, 2021 Category: Research Authors: Habiba Bouchab Abbas Ishaq Riad El Kebbaj Boubker Nasser Gabriele Saretzki Source Type: research

Immunoadsorption for heart failure is associated with normalization of iron metabolism
Biomarkers. 2021 Apr 12:1-21. doi: 10.1080/1354750X.2021.1904001. Online ahead of print.ABSTRACTAims: In heart failure patients, early stages are associated with increased iron levels, whereas iron deficiency is a common feature of chronic heart failure (HF). We investigated the acute and long-term changes in iron metabolism in HF patients after immunoadsorption treatment and intravenous immunoglobulin (IVIG) administration.Methods and results: Twenty-seven patients with HF with reduced ejection fraction (HFrEF) received a single cycle of immunoadsorption followed by IVIG administration. Left ventricular ejection fraction ...
Source: Biomarkers - April 12, 2021 Category: Research Authors: Karolina Weinmann Jakob Werner Wolfgang Rottbauer Mirjam Ke ßler Source Type: research

Protective effect of argan oil on DNA damage < em > in  vivo < /em > and < em > in  vitro < /em >
Conclusion: We found a striking effect of AO by ameliorating DNA damage after iron overload in a mouse liver model and in human fibroblasts by hyperoxia adding compelling evidence to the protective mechanisms of AO and OO.PMID:33843382 | DOI:10.1080/1354750X.2021.1905068 (Source: Biomarkers)
Source: Biomarkers - April 12, 2021 Category: Research Authors: Habiba Bouchab Abbas Ishaq Riad El Kebbaj Boubker Nasser Gabriele Saretzki Source Type: research

Immunoadsorption for heart failure is associated with normalization of iron metabolism
Biomarkers. 2021 Apr 12:1-21. doi: 10.1080/1354750X.2021.1904001. Online ahead of print.ABSTRACTAims: In heart failure patients, early stages are associated with increased iron levels, whereas iron deficiency is a common feature of chronic heart failure (HF). We investigated the acute and long-term changes in iron metabolism in HF patients after immunoadsorption treatment and intravenous immunoglobulin (IVIG) administration.Methods and results: Twenty-seven patients with HF with reduced ejection fraction (HFrEF) received a single cycle of immunoadsorption followed by IVIG administration. Left ventricular ejection fraction ...
Source: Biomarkers - April 12, 2021 Category: Research Authors: Karolina Weinmann Jakob Werner Wolfgang Rottbauer Mirjam Ke ßler Source Type: research

Protective effect of argan oil on DNA damage < em > in  vivo < /em > and < em > in  vitro < /em >
Conclusion: We found a striking effect of AO by ameliorating DNA damage after iron overload in a mouse liver model and in human fibroblasts by hyperoxia adding compelling evidence to the protective mechanisms of AO and OO.PMID:33843382 | DOI:10.1080/1354750X.2021.1905068 (Source: Biomarkers)
Source: Biomarkers - April 12, 2021 Category: Research Authors: Habiba Bouchab Abbas Ishaq Riad El Kebbaj Boubker Nasser Gabriele Saretzki Source Type: research

Immunoadsorption for heart failure is associated with normalization of iron metabolism
Biomarkers. 2021 Apr 12:1-21. doi: 10.1080/1354750X.2021.1904001. Online ahead of print.ABSTRACTAims: In heart failure patients, early stages are associated with increased iron levels, whereas iron deficiency is a common feature of chronic heart failure (HF). We investigated the acute and long-term changes in iron metabolism in HF patients after immunoadsorption treatment and intravenous immunoglobulin (IVIG) administration.Methods and results: Twenty-seven patients with HF with reduced ejection fraction (HFrEF) received a single cycle of immunoadsorption followed by IVIG administration. Left ventricular ejection fraction ...
Source: Biomarkers - April 12, 2021 Category: Research Authors: Karolina Weinmann Jakob Werner Wolfgang Rottbauer Mirjam Ke ßler Source Type: research

Protective effect of argan oil on DNA damage < em > in  vivo < /em > and < em > in  vitro < /em >
Conclusion: We found a striking effect of AO by ameliorating DNA damage after iron overload in a mouse liver model and in human fibroblasts by hyperoxia adding compelling evidence to the protective mechanisms of AO and OO.PMID:33843382 | DOI:10.1080/1354750X.2021.1905068 (Source: Biomarkers)
Source: Biomarkers - April 12, 2021 Category: Research Authors: Habiba Bouchab Abbas Ishaq Riad El Kebbaj Boubker Nasser Gabriele Saretzki Source Type: research

Immunoadsorption for heart failure is associated with normalization of iron metabolism
Biomarkers. 2021 Apr 12:1-21. doi: 10.1080/1354750X.2021.1904001. Online ahead of print.ABSTRACTAims: In heart failure patients, early stages are associated with increased iron levels, whereas iron deficiency is a common feature of chronic heart failure (HF). We investigated the acute and long-term changes in iron metabolism in HF patients after immunoadsorption treatment and intravenous immunoglobulin (IVIG) administration.Methods and results: Twenty-seven patients with HF with reduced ejection fraction (HFrEF) received a single cycle of immunoadsorption followed by IVIG administration. Left ventricular ejection fraction ...
Source: Biomarkers - April 12, 2021 Category: Research Authors: Karolina Weinmann Jakob Werner Wolfgang Rottbauer Mirjam Ke ßler Source Type: research

Integrated Analysis of mRNA-m < sup > 6 < /sup > A-protein Profiles Reveals Novel Insights into the Mechanisms for Cadmium-induced Urothelial Transformation
Conclusion Our multi-omics analysis provided a comprehensive reference map of gene activity and revealed m6A signaling pathways crucial for Cd2+ carcinogenesis.PMID:33830842 | DOI:10.1080/1354750X.2021.1913513 (Source: Biomarkers)
Source: Biomarkers - April 8, 2021 Category: Research Authors: Bin Wu Xu Jiang Yapeng Huang Xiaoling Ying Haiqing Zhang Bixia Liu Zhuo Li Dengfeng Qi Weidong Ji Xingming Cai Source Type: research

Urine soluble urokinase plasminogen activator receptor as a potential biomarker of lupus nephritis activity
Biomarkers. 2021 Apr 7:1-19. doi: 10.1080/1354750X.2021.1910343. Online ahead of print.ABSTRACTThere is a lack of noninvasive biomarkers to identify lupus nephritis (LN). Soluble urokinase plasminogen activator receptor (suPAR) is a sensitive biomarker of ongoing inflammation and a potential marker of podocyte dysfunction. The aim of this study was to assess urine and plasma suPAR in LN.14 systemic lupus erythematosus (SLE) patients with newly diagnosed LN, 8 active SLE patients (SLEDAI>8) without LN and 31 healthy individuals were enrolled. Urine and plasma samples were taken before the initiation of LN induction thera...
Source: Biomarkers - April 7, 2021 Category: Research Authors: Szilard Burcsar Gergely Toldi L ászló Kovács Bal ázs Szalay Barna V ásárhelyi Attila Balog Source Type: research

Antioxidant system biomarkers of freshwater mussel (Unio tigridis) respond to nanoparticle (Al(2)O(3), CuO, TiO(2)) exposures
This study aimed to investigate the response of the antioxidant enzymes of U. tigridis following exposure to NPs.MATERIALS AND METHODS: The mussels were exposed to different concentrations (0, 1, 3, 9 mg NP/L) of Al2O3, CuO and TiO2 NPs for 14 days and subsequently, the activities of CAT (catalase), SOD (superoxide dismutase), GPx (glutathione peroxidase), GST (glutathione S-transferase) and GR (glutathione reductase) were measured in the gill and digestive gland. Mussels were fed with cultured unicellular algae (Chlorella vulgaris) during experiments.RESULTS: Data showed that the consumption rate of algae by mussels were ...
Source: Biomarkers - March 30, 2021 Category: Research Authors: Esin G Canli Mustafa Canli Source Type: research

MR-proAdrenomedullin as predictor of renal replacement therapy in a cohort of critically ill patients with COVID-19
Biomarkers. 2021 Mar 23:1-20. doi: 10.1080/1354750X.2021.1905067. Online ahead of print.ABSTRACTBACKGROUND: Coronavirus Disease 2019 (COVID-19), caused by the novel coronavirus (SARS-CoV-2), has led to a large number of patients having to be admitted to intensive care because of respiratory failure and multi-organ dysfunction. About 20% of critically ill patients with COVID-19 require renal replacement therapy (RRT). However, data on the prediction of acute kidney injury requiring RRT is lacking. Novel biomarkers, such as mid-regional pro-adrenomedullin (MR-proADM) might be likely candidates for risk assessment due to its ...
Source: Biomarkers - March 23, 2021 Category: Research Authors: Kevin Roedl Dominik Jarczak Marlene Fischer Munif Haddad Olaf Boenisch Geraldine de Heer Christoph Burdelski Daniel Frings Barbara Sensen Mahir Karakas Stefan Kluge Axel Nierhaus Source Type: research

Automatic text-mining as an unbiased approach to uncover molecular associations between periodontitis and coronary artery disease
Biomarkers. 2021 Mar 19:1-22. doi: 10.1080/1354750X.2021.1904002. Online ahead of print.ABSTRACTThe increasing prevalence of periodontal and cardiovascular diseases is the result of a sedentary lifestyle associated with poor diet, obesity, hypercholesterolemia, smoking habits, alcohol consumption and stress. The present study aims to uncover molecular associations between periodontitis and coronary heart disease using an unbiased strategy of automatic text mining traditionally applied to bibliometric studies. A total of 1,590 articles on these diseases were retrieved from the Web of knowledge database and searched using th...
Source: Biomarkers - March 19, 2021 Category: Research Authors: F ábio Trindade Lu ís Perpétuo Rita Ferreira Adelino Leite-Moreira In ês Falcão-Pires Sofia Guedes Rui Vitorino Source Type: research

MeCP2 attenuates cardiomyocyte hypoxia/reperfusion-induced injury via regulation of the SFRP4/Wnt/ β-catenin axis
CONCLUSIONS: MeCP2 attenuated H/R-induced injury in H9c2 cardiomyocytes by modulating the SFRP4/Wnt/β-catenin axis, which suggested that MeCP2 might serve as a therapeutic target of patients with AMI after reperfusion.PMID:33726573 | DOI:10.1080/1354750X.2021.1903999 (Source: Biomarkers)
Source: Biomarkers - March 17, 2021 Category: Research Authors: Nan Li Tao Zhang Mengying He Yudong Mu Source Type: research

Exposure to 1,3-Butadiene in the U.S. Population: National Health and Nutrition Examination Survey 2011-2016
Biomarkers. 2021 Mar 17:1-40. doi: 10.1080/1354750X.2021.1904000. Online ahead of print.ABSTRACT1,3-Butadiene is a volatile organic compound with a gasoline-like odor that is primarily used as a monomer in the production of synthetic rubber. The International Agency for Research on Cancer has classified 1,3-butadiene as a human carcinogen. We assessed 1,3-butadiene exposure in the U.S. population by measuring its urinary metabolites N-acetyl-S-(3,4-dihydroxybutyl)-L-cysteine (34HBMA), N-acetyl-S-(1-hydroxymethyl-2-propenyl)-L-cysteine (1HMPEMA), N-acetyl-S-(2-hydroxy-3-butenyl)-L-cysteine (2HBEMA), and N-acetyl-S-(4-hydrox...
Source: Biomarkers - March 17, 2021 Category: Research Authors: Alma Nieto Luyu Zhang Deepak Bhandari Wanzhe Zhu Benjamin C Blount V íctor R De Jesús Source Type: research

MeCP2 attenuates cardiomyocyte hypoxia/reperfusion-induced injury via regulation of the SFRP4/Wnt/ β-catenin axis
CONCLUSIONS: MeCP2 attenuated H/R-induced injury in H9c2 cardiomyocytes by modulating the SFRP4/Wnt/β-catenin axis, which suggested that MeCP2 might serve as a therapeutic target of patients with AMI after reperfusion.PMID:33726573 | DOI:10.1080/1354750X.2021.1903999 (Source: Biomarkers)
Source: Biomarkers - March 17, 2021 Category: Research Authors: Nan Li Tao Zhang Mengying He Yudong Mu Source Type: research

Exposure to 1,3-Butadiene in the U.S. Population: National Health and Nutrition Examination Survey 2011-2016
Biomarkers. 2021 Mar 17:1-40. doi: 10.1080/1354750X.2021.1904000. Online ahead of print.ABSTRACT1,3-Butadiene is a volatile organic compound with a gasoline-like odor that is primarily used as a monomer in the production of synthetic rubber. The International Agency for Research on Cancer has classified 1,3-butadiene as a human carcinogen. We assessed 1,3-butadiene exposure in the U.S. population by measuring its urinary metabolites N-acetyl-S-(3,4-dihydroxybutyl)-L-cysteine (34HBMA), N-acetyl-S-(1-hydroxymethyl-2-propenyl)-L-cysteine (1HMPEMA), N-acetyl-S-(2-hydroxy-3-butenyl)-L-cysteine (2HBEMA), and N-acetyl-S-(4-hydrox...
Source: Biomarkers - March 17, 2021 Category: Research Authors: Alma Nieto Luyu Zhang Deepak Bhandari Wanzhe Zhu Benjamin C Blount V íctor R De Jesús Source Type: research

Blood Eosinophils as Predictor of Outcomes in patients hospitalized for COPD Exacerbations: A Prospective Observational Study
Biomarkers. 2021 Mar 16:1-25. doi: 10.1080/1354750X.2021.1903998. Online ahead of print.ABSTRACTPURPOSE: In the present prospective multicenter observational study, we evaluated the potential role of blood eosinophils on the outcomes of patients hospitalized for COPD exacerbations.MATERIAL AND METHODS: Consecutive patients>40 years with a previous COPD diagnosis were recruited. Blood eosinophils were measured on admission prior to the initiation of treatment and were evaluated in 3 groups (
Source: Biomarkers - March 16, 2021 Category: Research Authors: Konstantinos Kostikas Evgenia Papathanasiou Andriana Papaioannou Konstantinos Bartziokas Ilias Papanikolaou Emmanouil Antonakis Ioanna Makou Georgios Hillas Τheodoros Karampitsakos Ourania Papaioannou Aikaterini Dimakou Vicky Apollonatou Galateia Verykok Source Type: research

The impact of mitochondria related < em > POLG < /em > and < em > TFAM < /em > variants on breast cancer pathomorphological characteristics and patient outcomes
Conclusions. Our data suggest that variations in POLG and TFAM genes are important determinacies of tumor phenotype and disease outcome in breast cancer patients.PMID:33715547 | DOI:10.1080/1354750X.2021.1900397 (Source: Biomarkers)
Source: Biomarkers - March 15, 2021 Category: Research Authors: Ieva Golubickaite Rasa Ugenskiene Erika Korobeinikova Jurgita Gudaitiene Domas Vaitiekus Lina Poskiene Elona Juozaityte Source Type: research

Cyclic guanosine monophosphate and 10-year change in left ventricular mass: the Multi-Ethnic Study of Atherosclerosis (MESA)
Biomarkers. 2021 Mar 9:1-9. doi: 10.1080/1354750X.2021.1893811. Online ahead of print.ABSTRACTPurpose: Cyclic guanosine monophosphate (cGMP) is a second messenger for natriuretic peptide (NP) and nitric oxide pathways; its enhancement a target for heart failure and cardiovascular disease (CVD). We evaluated whether plasma cGMP was associated with change in left ventricular mass (LVM) among individuals free of CVD and if this differed by sex.Methods and Results: In 611 men and 612 women aged 45-84 years with plasma cGMP measured at baseline and cardiac MRI performed at baseline and 10 years later, we tested associations of ...
Source: Biomarkers - March 15, 2021 Category: Research Authors: Vinita Subramanya Di Zhao Pamela Ouyang Wendy Ying Dhananjay Vaidya Chiadi E Ndumele Joao A Lima Eliseo Guallar Ron C Hoogeveen Sanjiv J Shah Susan R Heckbert David A Kass Wendy S Post Erin D Michos Source Type: research

The impact of mitochondria related < em > POLG < /em > and < em > TFAM < /em > variants on breast cancer pathomorphological characteristics and patient outcomes
Conclusions. Our data suggest that variations in POLG and TFAM genes are important determinacies of tumor phenotype and disease outcome in breast cancer patients.PMID:33715547 | DOI:10.1080/1354750X.2021.1900397 (Source: Biomarkers)
Source: Biomarkers - March 15, 2021 Category: Research Authors: Ieva Golubickaite Rasa Ugenskiene Erika Korobeinikova Jurgita Gudaitiene Domas Vaitiekus Lina Poskiene Elona Juozaityte Source Type: research

Cyclic guanosine monophosphate and 10-year change in left ventricular mass: the Multi-Ethnic Study of Atherosclerosis (MESA)
Biomarkers. 2021 Mar 9:1-9. doi: 10.1080/1354750X.2021.1893811. Online ahead of print.ABSTRACTPurpose: Cyclic guanosine monophosphate (cGMP) is a second messenger for natriuretic peptide (NP) and nitric oxide pathways; its enhancement a target for heart failure and cardiovascular disease (CVD). We evaluated whether plasma cGMP was associated with change in left ventricular mass (LVM) among individuals free of CVD and if this differed by sex.Methods and Results: In 611 men and 612 women aged 45-84 years with plasma cGMP measured at baseline and cardiac MRI performed at baseline and 10 years later, we tested associations of ...
Source: Biomarkers - March 15, 2021 Category: Research Authors: Vinita Subramanya Di Zhao Pamela Ouyang Wendy Ying Dhananjay Vaidya Chiadi E Ndumele Joao A Lima Eliseo Guallar Ron C Hoogeveen Sanjiv J Shah Susan R Heckbert David A Kass Wendy S Post Erin D Michos Source Type: research

Readily available biomarkers predict poor survival in metastatic pancreatic cancer
Biomarkers. 2021 Mar 5:1-15. doi: 10.1080/1354750X.2021.1893814. Online ahead of print.ABSTRACTBACKGROUND: Identification of metastatic pancreatic cancer (mPC) patients with worst prognosis could help to tailor therapy. We evaluated readily available biomarkers for the prediction of 90-day mortality in a nationwide cohort of mPC patients.METHODS: Patients with synchronous mPC were included from the Netherlands Cancer Registry (2015-2017). Baseline CA19-9, albumin, CRP, LDH, CRP/albumin ratio, and (modified) Glasgow Prognostic Score ((m)GPS composed of albumin and CRP) were evaluated. Multivariable logistic regression analy...
Source: Biomarkers - March 5, 2021 Category: Research Authors: Marin Strijker Eran van Veldhuisen Lydia G van der Geest Olivier R Busch Maarten F Bijlsma Nadia Haj Mohammad Marjolein Y Homs Jeanin E van Hooft Joanne Verheij Judith de Vos-Geelen Johanna W Wilmink Ewout W Steyerberg Marc G Besselink Hanneke W van Laarh Source Type: research

Tissue < em > N- < /em > linked glycosylation as potential prognostic biomarker for biochemical recurrence-free survival
CONCLUSIONS: Tissue N-glycans are a powerful prognostic tool and can be an asset in PCa as the ratio of 3AFc/MA is independently associated with BCR-free survival. This could be of clinical use in guiding patients following radical prostatectomy, e.g. referral to adjuvant radiotherapy. Further elaboration of this biomarker is warranted.PMID:33657946 | DOI:10.1080/1354750X.2021.1891290 (Source: Biomarkers)
Source: Biomarkers - March 4, 2021 Category: Research Authors: Tijl Vermassen Arne Van Den Broeck Nicolaas Lumen Nico Callewaert Sylvie Rottey Joris Delanghe Source Type: research

Clinical significance of serum hepcidin in the diagnosis and treatment of patients with anemia of chronic disease: a meta-analysis
CONCLUSION: Serum hepcidin assay is a valuable method to diagnose ACD in patients. However, due to the limitations of the quantity and quality of the research, the above conclusions need more research to verify.PMID:33653208 | DOI:10.1080/1354750X.2021.1893812 (Source: Biomarkers)
Source: Biomarkers - March 3, 2021 Category: Research Authors: Jie Han Kai Wang Source Type: research