Biomarkers and short-term prognosis in COVID-19.
CONCLUSIONS: In patients with COVID-19, increased concentrations of cTnI, D-dimer, CRP and LDH are associated with short-term mortality. Of these, cTnI provides better mortality risk prediction. However, differences with D-dimer were non-significant. PMID: 33426934 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - January 13, 2021 Category: Research Tags: Biomarkers Source Type: research

Copeptin level differentiates takotsubo cardiomyopathy from acute myocardial infarction.
Authors: Szarpak L, Gasecka A, Opiełka M, Gilis-Malinowska N, Filipiak KJ, Jaguszewski MJ Abstract Serum concentration of copeptin has a prognostic value in several clinical conditions, including myocardial infarction, stroke, pneumonia or chronic obstructive pulmonary disease. We attempted to conduct a systematic review and meta-analysis to answer the question whether copeptin can be used as a parameter differentiating between takotsubo cardiomyopathy (TTC) and acute myocardial infarction (AMI). We performed a metaanalysis of four studies including 109 patients with TTC and 120 patients with AMI, which showed low...
Source: Biomarkers - January 13, 2021 Category: Research Tags: Biomarkers Source Type: research

Circulating miR-21 as a Potential Biomarker in Human Digestive System Carcinoma: A Systematic Review and Diagnostic Meta-Analysis.
CONCLUSION: This meta-analysis demonstrated that circulating miR-21 levels can be used to monitor the digestive system carcinomas. Therefore, miR-21 can be a useful biomarker of progression and fair diagnosis in GICs patients. PMID: 33434077 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - January 13, 2021 Category: Research Tags: Biomarkers Source Type: research

Patients with acute myocardial infarction and atrial fibrillation: association of anemia with risk of in-hospital bleeding, stroke and other death causes.
Authors: Guo SD, Bai Y, Liu XY, Liu Y, Wang ZZ, Zhong P Abstract Purposes: To explore the association of anemia with risk of outcomes of in-hospital patients with acute myocardial infarction (AMI) and atrial fibrillation (AF). Methods: Patients with AF and AMI at their first hospitalizations in three hospitals (Beijing Tongren Hospital, Beijing Friendship Hospital, Capital Medical University and China-Japan Friendship Hospital) were retrospectively reviewed and divided into two groups (with vs. without anemia) according to hemoglobin within one day before or after admission. Results: 864 patients with AF and AMI (m...
Source: Biomarkers - January 9, 2021 Category: Research Tags: Biomarkers Source Type: research

Environmental Biomonitoring by Snails.
Authors: Dhiman V, Pant D Abstract Bio-indicator systems are vital in terms of monitoring of pollutants around the world. The impact of environmental change can be monitored by employing the responsive behavior of snails. Heavy metal and organic pollutants affects snail reproduction, mortality, and normal metabolic activities. Various changes like a discontinuity in food intake, growth rate, twitching, and quenching of tentacles, are the biomarkers of the snails for biomonitoring. Different snails can bio-monitor eco-toxicological urban pollution, oil pollutant, terrestrial pollution, pesticide pollutants, mercury ...
Source: Biomarkers - January 9, 2021 Category: Research Tags: Biomarkers Source Type: research

Telomere length and signal joint T-cell receptor rearrangement excision circles as biomarkers for chronological age estimation.
Authors: Elmadawy MA, Abdulah OA, El Gazzar WB, Ahmad ES, Ameen SG, Abdelkader A Abstract BACKGROUND: Chronological age estimation is a challenging marker in the field of forensic medicine. The current study aimed to investigate the accuracy of signal joint T-cell receptor rearrangement excision circles (sjTRECs) quantification and telomere length measurement as methods for estimating chronological age. METHODS: Telomere length was estimated in the DNA derived from the buccal cells through estimating the telomeric restriction fragment (TRF) length using TeloTTAGGG Telomere Length Assay while the sjTRECs quantif...
Source: Biomarkers - January 7, 2021 Category: Research Tags: Biomarkers Source Type: research

miR-124-3p combined with miR-506-3p delay hepatic carcinogenesis via modulating sirtuin 1.
Conclusion: It was observed that miR-124-3p and miR-506-3p could cooperatively retard liver cancer cell growth via co-inhibiting SIRT1 protein expression. PMID: 33401967 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - January 7, 2021 Category: Research Tags: Biomarkers Source Type: research

The diagnostic and clinicopathological value of Trefoil Factor 3 in patients with gastric cancer: a systematic review and meta-analysis.
This study aims to assess the diagnostic value of TFF3 and the correlation between TFF3 expression (TFF3+) and high-risk clinicopathological features in patients with GC. Material and method PubMed, The Cochrane, EMbase, and Web of Science were retrieved comprehensively to collect relevant literature. The search ended on May 31, 2020. All data were analysed using Stata 12.0 software. The sensitivity and specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), area under curve (AUC), and the pooled odds ratio (OR) were calculated. Result Seventeen articles including 2167 ca...
Source: Biomarkers - January 7, 2021 Category: Research Tags: Biomarkers Source Type: research

Association between nutrient intake and telomere length in Japanese female university students.
CONCLUSIONS: Our findings suggest that variation in vitamin A intake might influence telomere attrition in healthy individuals. PMID: 33393836 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - January 6, 2021 Category: Research Tags: Biomarkers Source Type: research

Toxicity and biomarkers of micro-plastic in aquatic environment: A review.
Authors: Suman KH, Haque N, Uddin J, Begum MS, Sikder MH Abstract Microplastics (MPs;
Source: Biomarkers - December 13, 2020 Category: Research Tags: Biomarkers Source Type: research

Elevated serum ferritin level effectively discriminates severity illness and liver injury of coronavirus disease 2019 pneumonia.
Authors: Cao P, Wu Y, Wu S, Wu T, Zhang Q, Zhang R, Wang Z, Zhang Y Abstract AIM: ferritin is a hepatic protein that plays vital roles in diagnosing and predicting diseases, but its potential in coronavirus disease 2019 (COVID-19) remains unknown. Method: we collected clinical records from 79 COVID-19 patients at Wuhan Union hospital (China). Spearman's correlation analysis, receiver operating characteristic (ROC) curve and Kaplan-Meier survival curves were employed. RESULTS: patients with elevated ferritin levels had a higher incidence of severity illness (50.0% vs 2.9%) and liver injury (52.3% vs 20.0%) when ...
Source: Biomarkers - December 8, 2020 Category: Research Tags: Biomarkers Source Type: research

The Receptor for Advanced Glycation End Product (RAGE) Pathway in COVID-19.
CONCLUSIONS: In the present study, patients with high sRAGE levels were younger and had asymptomatic COVID-19. Patients with low sRAGE levels were elderly patients with lung involvement, which indicates that the RAGE pathway plays an important role in the aggravation of COVID-19. PMID: 33284049 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - December 8, 2020 Category: Research Tags: Biomarkers Source Type: research

Examination of Xylene Exposure in the U.S. Population Through Biomonitoring: NHANES 2005-2006, 2011-2016.
Authors: De Jesús VR, Milan DF, Yoo YM, Zhang L, Zhu W, Bhandari D, Murnane KS, Blount BC Abstract Xylenes are aromatic hydrocarbons used for industrial applications such as the production of petrochemicals and plastics. Acute xylene exposures can negatively impact health through neurotoxicity and irritation of respiratory and dermal tissues. We quantified urinary biomarkers of xylene exposure [2-methylhippuric acid (2MHA) and a mixture of 3- and 4-methylhippuric acids (34MH)] in a representative sample of the U.S. population. Spot urine obtained during the National Health and Nutrition Examination Survey 20...
Source: Biomarkers - December 8, 2020 Category: Research Tags: Biomarkers Source Type: research

Antioxidant responses and lipid peroxidation can be used as sensitive indicators for the heavy metals risk assessment of the Wei River: a case study of planarian Dugesia japonica.
CONCLUSION: We speculate that the heavy metal ions in the Wei River, especially Cr3+, Hg2+ and Pb2+, may give rise to oxidative damage on planarians. These findings illustrate that planarian can serve as an indicator of aquatic ecosystem pollution, antioxidant responses and lipid peroxidation can also be used as sensitive indicators and provided an excellent opportunity for urban river risk assessment. PMID: 33225756 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - November 24, 2020 Category: Research Tags: Biomarkers Source Type: research

Comparing cotinine and NNAL verification of self-reported smoking status among Lung Cancer Screening eligible population from the 2007-2014 National Health and Nutrition Examination Survey (NHANES).
Authors: Li W, Liu B Abstract Biochemical verification of self-reported smoking status is not common among the population eligible for lung cancer screening (LCS). We used urinary NNAL (4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol and its glucuronides) and serum cotinine as the gold standard to determine the validity and reliability of self-reported smoking status from the 2007-2014 National Health and Nutrition Examination Survey (NHANES). We found 2.3% (n = 652, equivalent to 5.3 million weighted population) of adults eligible for LCS according to the current United States Preventive Services Task ...
Source: Biomarkers - November 21, 2020 Category: Research Tags: Biomarkers Source Type: research

Sub-acute oral toxicity study of aqueous extract of tobacco leaves (Nicotiana tabacum L) on lipid profile, the tissue, and serum of the liver and kidney of male Wistar rats.
CONCLUSION: Thus, extract of tobacco leaves can greatly influence the body lipid profile, beside the serum and tissues of the liver. PMID: 33213209 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - November 21, 2020 Category: Research Tags: Biomarkers Source Type: research

Teprenone ameliorates Diclofenac-induced Small Intestinal Injury via Inhibiting Protease Activated Receptors 1 and 2 activity.
CONCLUSION: Our study presents a new view that teprenone might protect NSAIDs-induced (diclofenac) intestinal injury via suppressing the expression of PAR1 and PAR2. PMID: 33176506 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - November 14, 2020 Category: Research Tags: Biomarkers Source Type: research

One fits all hs troponin or more personalized dual markers strategies in the primary diagnostic assessment of patients with suspected acute coronary syndrome?
Authors: Möckel M PMID: 33175594 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - November 13, 2020 Category: Research Tags: Biomarkers Source Type: research

The role of immune PSA complex (iXip) in the prediction of prostate cancer.
CONCLUSION: In our experience, immune PSA complexes are not predictors of PCa. iXip analysis should not be included in the diagnostic pathway of patients at increased risk of PCa. PMID: 33100063 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - October 28, 2020 Category: Research Tags: Biomarkers Source Type: research

Prognostic association of routinely measured biomarkers in patients admitted to critical care: a systematic review.
Conclusions: Simple regression models have so far proved inadequate for the complexity of data available from routine blood sampling in critical care. Adoption of a direct causal framework may help better assess mechanistic processes, aid design of future studies, and guide clinical decision making using routine data. PMID: 33103483 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - October 28, 2020 Category: Research Tags: Biomarkers Source Type: research

Correction.
Authors: PMID: 33103486 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - October 28, 2020 Category: Research Tags: Biomarkers Source Type: research

Serum Anion Gap at Admission Predicts All-Cause Mortality in Critically Ill Patients with Cerebral Infarction: Evidence from the MIMIC-III Database.
CONCLUSIONS: High AG was associated with increased risk of all-cause mortality, and AG could be an independent short-term prognostic factor for cerebral infarction. PMID: 33103496 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - October 28, 2020 Category: Research Tags: Biomarkers Source Type: research

Exposure to variable doses of Nickel oxide nanoparticles disturbs serum biochemical parameters and oxidative stress biomarkers from vital organs of albino mice in a sex specific manner.
Conclusion: Toxic effects of NiO NPs were dose and sex dependent and they were more pronounced at higher dose and in male mice. PMID: 33095078 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - October 25, 2020 Category: Research Tags: Biomarkers Source Type: research

Can serum resistin predict severity of acute pancreatitis?
This study aimed at assessing the role of baseline serum resistin levels in predicting the SAP. METHODS: This prospective study collected data from 130 AP patients from July 2017 to Nov 2018. Parameters measured included the demographic profile, serum resistin at admission, severity scores, hospital stay, surgery, and mortality. Patients were divided into two groups, severe and non-severe AP. Two groups were compared for baseline characteristics, serum resistin levels, hospital stay, surgery and mortality. RESULTS: Among 130 patients, 53 patients had SAP. SAP patients had higher BMI, baselines CRP, APACHE II and CT...
Source: Biomarkers - October 24, 2020 Category: Research Tags: Biomarkers Source Type: research

Bicuspid aortopathy - molecular involvement of microRNAs and MMP-TIMP.
Authors: Naito S, Petersen J, Sequeira-Gross T, Neumann N, Duque Escobar J, Zeller T, Reichenspurner H, Girdauskas E Abstract OBJECTIVES: We aimed to elucidate the correlation between expression patterns of aortic tissue microRNAs and the aortopathy formation in bicuspid aortic valve (BAV) disease. METHODS: All 65 patients who underwent elective aortic valve repair/replacement +/- proximal aortic replacement due to BAV disease with or without concomitant aortic aneurysm were identified from our BAV registry. Aortic tissue was collected intraoperatively from the ascending aorta at the greater and lesser curvatur...
Source: Biomarkers - October 24, 2020 Category: Research Tags: Biomarkers Source Type: research

A Biomarker Based Severity Progression Indicator for COVID-19: The Kuwait Prognosis Indicator Score.
CONCLUSION: We developed and validated a simple score calculated at time of diagnosis that can predict patients with severe COVID-19 disease reliably and that has been validated externally. The KPI score calculator is now available online at covidkscore.com. PMID: 33090050 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - October 24, 2020 Category: Research Tags: Biomarkers Source Type: research

Copeptin combined with either non-high sensitivity or high sensitivity cardiac troponin for instant rule-out of suspected non-ST segment elevation myocardial infarction.
Authors: Giannitsis E, Slagman A, Hamm CW, Gehrig S, Vollert JO, Huber K Abstract BACKGROUND: Whether Copeptin combined with high sensitivity troponin below the respective decision cutoffs improves rule-out of NSTEMI and may predict all-cause death at 30-day is under debate. METHODS: Data on 10,329 patients from 5 trials were pooled to evaluate the diagnostic and prognostic performance of an initial Copeptin below decision cutoff in combination with a (hs-(cTn) below the uppler limit of normal (ULN) compared to a) the initial (hs)-cTn alone in the standard serial sampling strategy based on the 99th percentile a...
Source: Biomarkers - October 15, 2020 Category: Research Tags: Biomarkers Source Type: research

In vitro evaluation of Annona muricata L. (Soursop) leaf methanol extracts on inhibition of tumorigenicity and metastasis of breast cancer cells.
Conclusion: LMAM proved as a potent ethno-chemopreventive agent and a potential lead in cancer treatment attributable to the synergistic interactive properties of phytoconstituents. PMID: 33048613 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - October 15, 2020 Category: Research Tags: Biomarkers Source Type: research

miR-455-3p alleviates propofol-induced neurotoxicity by reducing EphA4 expression in developing neurons.
Conclusion: Propofol treatment induces neurotoxicity and suppresses miR-455-3p levels in the developing hippocampal neurons. However, miR-455-3p could alleviate such neurotoxicity by reducing EphA4 expression, provided new insights into miR-455-3p as novel therapeutic target to prevent propofol-induced damages from bench to clinic. PMID: 33032457 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - October 11, 2020 Category: Research Tags: Biomarkers Source Type: research

Serum anti-M üllerian hormone levels are associated with low bone mineral density in premenopausal women.
Serum anti-Müllerian hormone levels are associated with low bone mineral density in premenopausal women. Biomarkers. 2020 Oct 07;:1-23 Authors: Yan Y, Chen W, Wang J, Huang J, Lv J, Zhao H, Guo L Abstract Objective: To investigate the associations between anti-Müllerian hormone (AMH) and bone mineral density (BMD) induced by ovarian insufficiency in premenopausal women.Methods: Subjects were consecutively enrolled from January 2015 to December 2018. Dual energy X-ray absorptiometry examination was set as the gold standard, with T-scores less than -2.5/-1 as thresholds for the definition of os...
Source: Biomarkers - October 9, 2020 Category: Research Tags: Biomarkers Source Type: research

Association between Cardiac Troponin I and Mortality in Patients with COVID-19.
Authors: Michela S, Barbara B, Cioffi SMG, Morenghi E, Leone FP, Maura F, Moriello G, Sandri MT Abstract Background: Severe pneumonia is pathological manifestation of Coronavirus Disease 2019 (COVID-19), however complications have been reported in COVID-19 patients with a worst prognosis. Aim of this study was to evaluate the role of high sensitivity cardiac troponin I (hs-TnI) in patients with SARS-CoV-2 infection.Methods: we retrospectively analyzed hs-TnI values measured in 523 patients (median age 64 years, 68% men) admitted to a university hospital in Milan, Italy, and diagnosed COVID-19.Results: A significant...
Source: Biomarkers - October 3, 2020 Category: Research Tags: Biomarkers Source Type: research

Extracellular vesicles released in blood of COVID-19 patients: mechanism for detection of cardiac troponin after myocardial injury?
Authors: Wu AHB, Zhang Y, Webber R PMID: 32977728 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - September 29, 2020 Category: Research Tags: Biomarkers Source Type: research

High Sensitivity Troponin-T for Prediction of Adverse Events in Patients with COVID-19.
Authors: Singh N, Anchan RK, Besser SA, Belkin MN, Dela Cruz M, Lee L, Yu D, Mehta N, Nguyen AB, Alenghat FJ Abstract Background: High sensitivity troponin-T (hs-TnT) has been associated with mortality in patients hospitalized with COVID-19. We aimed to determine if hs-TnT levels and their timing are independent predictors of adverse events in these patients.Design: Retrospective chart review was performed for all patients hospitalized at our institution between March 23rd and April 13th, 2020 who were found to be COVID-19-positive. Clinical, demographic, and laboratory variables including initial and peak hs-TnT w...
Source: Biomarkers - September 29, 2020 Category: Research Tags: Biomarkers Source Type: research

Evaluation of the genotoxic effect of heavy metals in pigeons from urban and rural habitat in Monterrey, Mexico, using the chromatin dispersion assay.
Authors: Ceyca-Contreras JP, Cortés-Gutiérrez EI, García-Salas JA, Dávila-Rodríguez MI, García-Hernández J Abstract Purpose: Evaluate genotoxic effect of heavy metals on Pigeon Erythrocytes (PE) from urban and rural habitat (outside of the city) in Monterrey, Mexico, using the chromatin dispersion assay.Materials and Methods: We quantified metals concentrations (Cd, Hg, Cu, and Pb) in tail feathers of 22 pigeons from an urban and a rural site in northeastern Mexico. DNA damage in peripheral blood erythrocytes was measured by chromatin dispersion assay in 13 pigeon li...
Source: Biomarkers - September 26, 2020 Category: Research Tags: Biomarkers Source Type: research

MR-proANP level predicts new onset atrial fibrillation in patients with acute myocardial infarction.
Conclusions: MR-proANP might be a good predictor of new-onset atrial fibrillation in patients with acute myocardial infarction. PMID: 32972251 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - September 26, 2020 Category: Research Tags: Biomarkers Source Type: research

Biomarkers of neurotoxicity, oxidative stress, hepatotoxicity and lipid peroxidation in Clarias gariepinus exposed to melamine and polyvinyl chloride.
CONCLUSION: C. gariepinus is an important bioindicator to monitor the ecotoxicological impact of plastic chemicals such as melamine, and polyvinyl chloride. PMID: 32962424 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - September 25, 2020 Category: Research Tags: Biomarkers Source Type: research

Photobiomodulation modulates inflammation and oral microbiome: a pilot study.
Conclusions: PBM reduces inflammatory burden in patients affected by OM and positively influences the composition of the oral microbiome. PMID: 32960109 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - September 23, 2020 Category: Research Tags: Biomarkers Source Type: research

Korean male active smokers: quantifying their smoking habits and the transformation factor among biomarkers in urine and blood.
CONCLUSIONS: The validated transformation factor connects epidemiological cohort studies with tobacco smoking exposure risk assessment. Hence, this study might be beneficial for further habit-based smoking risk assessments to obtain successful regional cession policies. PMID: 32912026 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - September 12, 2020 Category: Research Tags: Biomarkers Source Type: research

Galectin-3, GDF-15, and sST2 for the Assessment of Disease Severity and Therapy Response in patients suffering from inoperable Chronic Thromboembolic Pulmonary Hypertension.
This study examined sST2, GDF-15, and galectin-3 as indicators of disease severity and therapy response in chronic thromboembolic pulmonary hypertension (CTEPH).Methods: This study included 57 inoperable CTEPH patients who underwent balloon pulmonary angioplasty and 25 controls without cardiovascular disease. Biomarker levels were examined in relation to advanced hemodynamic impairment (tertile with worst right atrial pressure [RAP] and cardiac index), hemodynamic therapy response (normalized hemodynamics (meanPAP ≤25 mmHg, PVR ≤3 WU and RAP ≤6 mmHg) or a reduction of meanPAP ≥25%; PVR ≥35%, RA...
Source: Biomarkers - September 11, 2020 Category: Research Tags: Biomarkers Source Type: research

Can baseline C-reactive protein level predict functional outcome in acute ischemic stroke? A meta-analysis.
Conclusions: Elevated CRP level is significantly associated with poor functional outcome in patients with AIS. Baseline CRP level has potential to improve risk stratification of function outcome in AIS patients. PMID: 32892646 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - September 9, 2020 Category: Research Tags: Biomarkers Source Type: research

Relationship between handgrip strength and albuminuria in community-dwelling elderly Japanese subjects: The Shika study.
Conclusion Low HGS was associated with albuminuria in older men and women in Japan. PMID: 32893687 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - September 9, 2020 Category: Research Tags: Biomarkers Source Type: research

Statement of Retraction: IMPDH2 is highly expressed in breast cancer and predicts unfavourable prognosis.
Authors: PMID: 32873099 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - September 3, 2020 Category: Research Tags: Biomarkers Source Type: research

DNA methylation changes in promoter region of CDKN2A gene in workers exposed in construction environment.
Conclusions: In summary, the data suggest that altered levels of CDKN2A methylation in construction workers may be a potential biomarker of recent exposure in this environment. PMID: 32875942 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - September 3, 2020 Category: Research Tags: Biomarkers Source Type: research

The Myostatin rs1805086 variant is associated with obesity in Mexican adults, independently of metabolic risk factors.
Conclusion: Heterozygosity for rs1805086 showed a predisposition to having elevated overall and central obesity parameters. This association with adiposity seems to be independent of metabolic risk. PMID: 32838566 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - August 27, 2020 Category: Research Tags: Biomarkers Source Type: research

Serum MicroRNA on Inflammation: A Literature Review of Mouse Model Studies.
Authors: Lee A, Kim SN Abstract MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate target gene expression by binding to sequences in messenger RNA processing. Inflammation is a protective reaction from harmful stimuli. MiRNAs can be biomarkers of diseases related to inflammation and are widely expressed in serum. However, overall changes in serum miRNA levels during inflammation have yet to be observed. Here, we selected studies published until 20 January 2020 that examined miRNAs in mouse models of inflammation. Serum microRNA, inflammation, inflammatory and mouse were used as search terms to sele...
Source: Biomarkers - August 19, 2020 Category: Research Tags: Biomarkers Source Type: research

Plasma Tenascin-C: a prognostic biomarker in heart failure with preserved ejection fraction.
Authors: Kanagala P, Arnold JR, Khan JN, Singh A, Gulsin GS, Chan DS, Cheng ASH, Yang J, Li Z, Gupta P, Squire IB, McCann GP, Ng LL Abstract INTRODUCTION: Tenascin-C is a marker of interstitial fibrosis. We assessed whether plasma Tenascin-C differed between heart failure with preserved ejection fraction (HFpEF)and asymptomatic controls, and related to clinical outcomes.Materials and Methods: Prospective, observational study of 172 age and sex-matched subjects (HFpEF n = 130; controls n = 42, age 73 ± 9, males 50%) who underwent phenotyping with 20 plasma biomarkers,...
Source: Biomarkers - August 19, 2020 Category: Research Tags: Biomarkers Source Type: research

Soluble Intercellular Adhesion Molecule (ICAM)-1 detects invasive fungal infections in patients following liver transplantation.
Conclusion: The diagnostic deficiencies of routinely used microbiological procedures for IFI detection in patients after LTX may be reduced by plasmatic sICAM-1 measurements.Clinical Trial Notation. German Clinical Trials Register: DRKS00005480. PMID: 32803993 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - August 19, 2020 Category: Research Tags: Biomarkers Source Type: research

Clinical and molecular characteristics associated with survival among cancer patients receiving first-line anti-PD-1/PD-L1-based therapies.
Authors: Zhou Y, Wang C, Jiang Y, Ren P, Shao J, Tuersun P, Li W Abstract BACKGROUND: Anti-PD-1/PD-L1-based therapy has emerged recently, and we aimed to figure out the latent value of different clinical and molecular factors to predict the efficacy of immune checkpoint inhibitors (ICIs) therapy compared with non-immunotherapy in the first-line setting. METHODS: We assessed the clinical outcomes of 8711 patients in 13 trials receiving anti-PD-1/PD-L1-based therapy or non-immunotherapy as first-line treatment, and different predictors were investigated. RESULTS: Overall, compared with non-immunotherapy, anti...
Source: Biomarkers - August 5, 2020 Category: Research Tags: Biomarkers Source Type: research

Serum exosomal miR-122-5p is a new biomarker for both acute coronary syndrome and underlying coronary artery stenosis.
Conclusion: Serum exosomal miR-122-5p might be useful as a diagnostic biomarker for AMI and UA, and increased serum exosomal miR-122-5p levels could be useful to predict the severity of coronary lesions. PMID: 32723190 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - July 31, 2020 Category: Research Tags: Biomarkers Source Type: research

The potential benefit of a second C-reactive protein measurement in patients with gram-negative bacteraemia presenting to the emergency medicine department.
CONCLUSIONS: Patients with gram-negative bacteraemia can present with C-reactive protein within the range of apparently healthy individuals. A second C-reactive protein might help to avoid an erroneous decision regarding the severity of the infection. PMID: 32715769 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - July 28, 2020 Category: Research Tags: Biomarkers Source Type: research