CXCR4 as A Prognostic Biomarker in Gastrointestinal Cancer: A Meta-Analysis.
Conclusions: CXCR4 may serve as a prognostic indicator in GI cancer patients. PMID: 31244335 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - June 28, 2019 Category: Research Tags: Biomarkers Source Type: research

Potential use of transrenal DNA for non-invasive monitoring and prognosis of colorectal cancer.
Conclusion: Transrenal DNA offers new options to follow clinical treatment in mCRC. It demonstrates the ability to capture newly acquired mutations that has strong associative links to therapy resistance. Patients with these mutations fared poorly for survival outcomes and indicated possible prognostic value for transrenal DNA detection. PMID: 31220949 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - June 22, 2019 Category: Research Tags: Biomarkers Source Type: research

Copeptin, B-type natriuretic peptide and cystatin C are associated with incident symptomatic PAD.
Conclusion: Copeptin, N-BNP, and cystatin C were associated with incident symptomatic PAD, implying that these biomarkers are sensitive indicators of early subclinical PAD. PMID: 31215249 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - June 21, 2019 Category: Research Tags: Biomarkers Source Type: research

Heparanase is a predictive marker for high thrombus burden in patients with ST-segment elevation myocardial infarction.
Authors: Gurbuz AS, Ozturk S, Efe SC, Yılmaz MF, Yanik RE, Yaman A, Kirma C Abstract Objective: Heparanase (HPA) is an endo-β-D-glucuronidase capable of degrading heparin sulphate (HS) and heparin side chains. HPA plays a role in tumour growth, angiogenesis, cell invasion and in activation of the coagulation system. We aimed to investigate the relationship between HPA and thrombus burden (TB) in patients with ST-Segment Elevation Myocardial Infarction (STEMI). Methods: This prospective study enrolled 187 patients with STEMI who were treated with primary percutaneous coronary intervention (pPCI). Blood samples...
Source: Biomarkers - June 21, 2019 Category: Research Tags: Biomarkers Source Type: research

Circulating adiponectin as a biomarker in renal cell carcinoma: A systematic review and meta-analysis.
CONCLUSION: Low circulating adiponectin could be a predictive or risk factor for RCC. PMID: 31215811 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - June 21, 2019 Category: Research Tags: Biomarkers Source Type: research

Genotype-guided antiplatelet therapy compared with conventional therapy for patients with acute coronary syndromes: a systematic review and meta-analysis.
Conclusions: Genotype-guided strategies could reduce the rates of cardiovascular events without increasing bleeding events compared with conventional treatment in ACS. Future multi-center genotype-based RCTs are required to confirm these findings. PMID: 31215825 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - June 21, 2019 Category: Research Tags: Biomarkers Source Type: research

Identification of acute myocardial infarction in elderly patients using optimized highly sensitive troponin I thresholds.
Authors: von Jeinsen B, Liebetrau C, Palapies L, Tzikas S, Zeller T, Bickel C, Schmidt A, Tubaro M, Lackner KJ, Sar F, Baldus S, Zeiher AM, Blankenberg S, Gori T, Münzel T, Hamm CW, Wild PS, Keller T Abstract Purpose: Established diagnostic thresholds for high-sensitivity cardiac troponins (hs-cTn) might not apply for elderly patients as they are elevated irrespective of the presence of an acute myocardial infarction (AMI). Aim of the present study was to investigate hs-cTnI in elderly patients with suspected AMI and to calculate optimized diagnostic cut-offs. Material and Methods: Data from a prospective mult...
Source: Biomarkers - June 5, 2019 Category: Research Tags: Biomarkers Source Type: research

Serum ferritin as a candidate diagnostic biomarker of polycystic ovarian syndrome: a meta-analysis.
CONCLUSION: Our findings suggest that high serum ferritin level is significantly associated with PCOS and its potential as a biomarker is evident in its high diagnostic accuracy. However, additional studies are needed to confirm our claims. PMID: 31096807 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - May 19, 2019 Category: Research Tags: Biomarkers Source Type: research

Assessment of titanium dioxide nanoparticles toxicity via oral exposure in mice: Effect of dose and particle size.
CONCLUSION: Toxicity of TiO2NPs increases in a dose dependent manner and vice versa with particles size. The evaluated biomarkers are good indicators for TiO2NPs toxicity. More detailed studies are required before the recommendation of TiO2NPS as food additives. PMID: 31099265 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - May 19, 2019 Category: Research Tags: Biomarkers Source Type: research

Postmortem interval estimative through determination of catalase and δ -aminolevulinate dehydratase activities in hepatic, renal, skeletal muscle and cerebral tissues of Swiss mice.
CONCLUSION: With the association of this set of results it is possible to provide an estimate of PMI. Additionally, these results can be used as an auxiliary parameter associated with other methods to estimate PMI. PMID: 31094223 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - May 18, 2019 Category: Research Tags: Biomarkers Source Type: research

Effects of reduced exposure to cigarette smoking on changes in biomarkers of potential harm in adult smokers: results of combined analysis of two clinical studies.
Authors: Sakaguchi C, Miura N, Ohara H, Nagata Y Abstract PURPOSE: Nonconventional vapor products (NVP), designed to reduce exposure to cigarette smoke toxicants (CSTs), could cause changes in biomarkers of potential harm (BoPH). Although, NVPs reduced CSTs exposure compared to conventional cigarettes (CC), the changes in the BoPH values varied among the studies. Hence, further information on BoPH using NVPs is needed. MATERIAL AND METHODS: The data of two similarly designed studies using a kind of NVP, a noncombustion and nonheating inhaler type of smokeless tobacco product (NCIT) used under 31-day confinement...
Source: Biomarkers - May 16, 2019 Category: Research Tags: Biomarkers Source Type: research

Circulating microparticles in cardiovascular disease: Going on stage!
CONCLUSIONS: The levels of circulating microparticles have been associated with cardiovascular damage in asymptomatic patients as well as in patients who suffered a cardiovascular event, becoming promising diagnostics or prediction biomarkers in recent years. PMID: 31068021 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - May 11, 2019 Category: Research Tags: Biomarkers Source Type: research

Quantitative analysis of sarcosine with special emphasis on biosensors: a review.
Authors: Pundir CS, Deswal R, Yadav P Abstract The quantitative determination of sarcosine is of great importance in clinical chemistry, food and fermentation industries. Elevated sarcosine levels are associated with Alzheimer, dementia, prostate cancer, colorectal cancer, stomach cancer and sarcosinemia. This review summarizes the various methods for quantitative analysis of sarcosine with special emphasis on various strategies of biosensors and their analytical performance. The current biosensing methods have overcome the drawbacks of conventional methods. Sarcosine biosensors work optimally at pH 7.0 to 8.0 in t...
Source: Biomarkers - May 6, 2019 Category: Research Tags: Biomarkers Source Type: research

Early signatures of bleeding and mortality in patients on left ventricular assist device support: novel methods for personalized risk-stratification.
CONCLUSIONS: Early trends in routine bloodwork and platelet function may serve as novel signatures of patients at risk to experience adverse events. PMID: 31055944 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - May 6, 2019 Category: Research Tags: Biomarkers Source Type: research

Serum tau fragments as predictors of death or poor neurological outcome after out-of-hospital cardiac arrest.
CONCLUSIONS: Serum levels of tau fragments were unable to predict neurological outcome after OHCA. PMID: 31017476 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - April 26, 2019 Category: Research Tags: Biomarkers Source Type: research

Association between circulating microRNA-126 expression level and Tumor necrosis factor alpha in healthy smokers.
Authors: Elfiky AM, Mahmoud AA, Zeidan HM, Soliman MM Abstract INTRODUCTION: Smoking contributes to the death of a million people worldwide each year. Smokers experience an alteration in tumor necrosis factor-alpha (TNF-α), and the risk of expected lung cancer. The study aimed to investigate the expression levels of mir-126 and mir-124, as well as TNF-α as possible biomarkers of expected smoking-related diseases. METHODS: Twenty-five male smokers' age and sex-matched with 25 nonsmokers were recruited for the present study. Plasma expression levels of mir-126 and mir-124 were evaluated using quantita...
Source: Biomarkers - April 26, 2019 Category: Research Tags: Biomarkers Source Type: research

Comet Assay for Assessment of DNA Damage in Greenhouse Workers Exposed to Pesticides.
Authors: Cayir A, Coskun M, Coskun M, Cobanoglu H Abstract PURPOSE: The main goal of the present study was to determine DNA damage in pesticide-exposed greenhouse workers and pesticides non-exposed controls. MATERIALS AND METHODS: The DNA damage was measured by alkaline comet assay method (pH>13) in 41 greenhouse workers and 45 non-exposed individuals as the control. Pesticide exposure was assessed by duration of working in the greenhouse and pesticide application in the greenhouse time. DNA damage was estimated by Arbitrary Unit and Damage Frequency. RESULTS: Arbitrary Unit and Damage Frequency were con...
Source: Biomarkers - April 26, 2019 Category: Research Tags: Biomarkers Source Type: research

Similarities in mRNA expression of peripheral blood drug metabolizing enzymes and cancer marker genes with biopsy samples of head and neck cancer patients.
Conclusion: The data suggests that peripheral blood expression profiles could be used to monitor tobacco-induced HNSCC as well as the treatment response. PMID: 31002268 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - April 21, 2019 Category: Research Tags: Biomarkers Source Type: research

Tumour expressions of hypoxic markers predict the response to neo-adjuvant chemotherapy in children with inoperable rhabdomyosarcoma.
Conclusions Immunohistochemical expression pattern of 4 endogenous markers of hypoxia, in tumour tissue at diagnosis, emerges as a promising tool to predict response to naCHT in children with inoperable RMS. PMID: 30995126 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - April 19, 2019 Category: Research Tags: Biomarkers Source Type: research

Circulating MicroRNAs in Human Obesity: A Systematic Review.
CONCLUSION: Literature records 33 c-miRNAs confirmedly dysregulated in human obesity. Their predicted target genes are involved in pathways that could explain the development of obesity and its comorbidities. Further research will clarify the role of these miRNAs on metabolic diseases and their usefulness for the prognosis, prevention and treatment of obesity. PMID: 30990364 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - April 18, 2019 Category: Research Tags: Biomarkers Source Type: research

Phytochemicals, antioxidant activity and hepatoprotective effect of ginger (Zingiber officinale) on diethylnitrosamine toxicity in rats.
CONCLUSION: Ginger was able to reduce the severity of DEN-cytotoxicity in rats, which suggests a novel antioxidant role originating from this medicinal plant. PMID: 30979347 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - April 15, 2019 Category: Research Tags: Biomarkers Source Type: research

Cardiac Troponins Predict Adverse Clinical Outcomes In Stable Coronary Artery Disease: A Dose-response Meta-analysis of Prospective Studies.
CONCLUSION: Rising/detectable cTns was associated with increased risk of all-cause mortality, CV mortality, MI, HF and MACEs in SCAD in a dose-response manner. PMID: 30974974 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - April 13, 2019 Category: Research Tags: Biomarkers Source Type: research

Association between high-sensitivity cardiac troponin T and future cardiovascular incidence in a general Japanese population: Results from the Tohoku Medical Megabank Project.
This study determined whether hs-cTnT was detectable with N-terminal pro-b-type natriuretic peptide (NT-proBNP) and related to CV risk factors in a general Japanese population. MATERIALS AND METHODS: The Tohoku Medical Megabank Organization pooled individual participant data for a population-based cohort study in the Iwate prefecture (n = 30,193, age =60.2 ± 11.5 y). RESULTS: Hs-cTnT levels were higher in participants with hypertension, diabetes mellitus than in participants without these conditions (all Ps
Source: Biomarkers - April 13, 2019 Category: Research Tags: Biomarkers Source Type: research

Associations of rs1883832 and rs4810485 polymorphisms of CD40 gene with Myocardial Infarction in the Tunisian Population.
Authors: Soussi M, Kallel A, Ben Wafi S, Ben Halima M, Sanhaji H, Mourali MS, Jemaa R, Feki M Abstract CONTEXT: Cluster of differentiation 40 (CD40), and its ligand CD40L, are major co-stimulatory molecules whose interactions are important in both cellular and humoral immunity, and has been suggested to play a role in the pathogenesis of acute coronary syndrome. OBJECTIVE: The aim of this study was to examine the association of CD40 polymorphisms (-1 C > T (rs1883832) and 945G > T (rs4810485)) and myocardial infarction (MI), and to test the association of CD40 gene haplotypes w...
Source: Biomarkers - March 30, 2019 Category: Research Tags: Biomarkers Source Type: research

Thrombin generation is increased in patients with Clostridium difficile colitis - a pilot study.
CONCLUSIONS: The higher values of thrombin generation suggest that Clostridium difficile colitis increases the thromboembolic risk. The pattern of thrombin generation could identify patients with particularly higher thromboembolic risk. They are potential candidates for thromboprophylaxis strategies and monitorization. PMID: 30907672 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - March 27, 2019 Category: Research Tags: Biomarkers Source Type: research

Combination of sepsis biomarkers may indicate an invasive fungal infection in hematological patients.
Authors: Stoma I, Karpov I, Uss A, Krivenko S, Iskrov I, Milanovich N, Vlasenkova S, Lendina I, Belyavskaya K, Cherniak V Abstract BACKGROUND: Invasive fungal infections are a major threat to a large cohort of immunocompromised patients, including patients with chemotherapy-associated neutropenia. Early differential diagnosis with bacterial infections is often complicated, what leads to a delay in empiric antifungal therapy and increases risk for adverse outcome. Accessibility and performance of specific fungal antigen and PCR-tests is still limited, while sepsis biomarkers are more broadly used in most settings cu...
Source: Biomarkers - March 27, 2019 Category: Research Tags: Biomarkers Source Type: research

The association between metabolic syndrome severity and oxidative stress induced by maximal exercise testing - A cross-sectional study.
CONCLUSIONS: A O2 peak test to exhaustion failed to induce OS in participants with MetS. There were no associations between MetS severity and spot OS or EIOS biomarkers. PMID: 30907677 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - March 27, 2019 Category: Research Tags: Biomarkers Source Type: research

Is C-reactive protein elevated in obstructive sleep apnoea? A systematic review and meta-analysis.
This study examined whether circulating C-reactive protein (CRP) is elevated in obstructive sleep apnoea (OSA) independent of the confounding effects of comorbidities, smoking, body mass index (BMI), age and gender. METHODS: A systematic review of the literature was performed using PubMed, Embase and Cochrane databases from 1st January 1997 to 1st November 2017 using the key words obstructive sleep apnoea and C-Reactive protein to identify full text English language studies that compared CRP in adult non-smoking OSA participants without comorbidities and adult healthy non-smoking control participants matched for BMI, a...
Source: Biomarkers - March 27, 2019 Category: Research Tags: Biomarkers Source Type: research

Evaluation of oxidative stress biomarkers of rabbits liver exposed to thermooxidized virgin olive oil obtained from Blanquette olive Cultivars.
Authors: Ayari D, Boukazoula F, Soumati B, Souiki L Abstract OBJECTIVE: This work aimed to study the effect of temperature in variation of fatty acid profiles of virgin olive oil (VOO) and to evaluate the impact of the consumption of this thermo oxidized VOO on metabolic oxidative stress Materials and methods: effect of consumption of fresh or thermo-oxidized VOO on rabbits was studied. The animals were distributed in groups of 6 rabbits each and were fed for four weeks with the incorporation of 15% VOO either fresh or heated during one, two, three, or four hours. The liver was examined for the level of reduced glu...
Source: Biomarkers - March 27, 2019 Category: Research Tags: Biomarkers Source Type: research

Validation of Urinary Sphingolipid Metabolites as Biomarker of Effect for Fumonisins Exposure in Kenyan Children.
CONCLUSIONS: Sa and So were detectable in 95.07% and 98.94% of samples respectively. Creatinine adjusted mean levels and standard deviation of Sa, So, and Sa/So ratio were 1.23 ± 2.18, 4.99 ± 8.3, and 0.296 ± 0.587 nM. These results further confirmed findings in studies with human adults, i.e. urinary Sa, So levels, and Sa/So ratio are good biomarkers to assess FNs exposure in children. PMID: 30821509 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - March 5, 2019 Category: Research Tags: Biomarkers Source Type: research

Association of Metabolites Reflecting Type III and VI Collagen Formation with Modified Rodnan Skin Score in Systemic Sclerosis - a Cross-sectional Study.
The objective was to investigate blood-based biomarkers of type I (PRO-C1), III (PRO-C3), and VI (PRO-C6) collagen formation in systemic sclerosis (SSc) patients and examine their correlation to modified Rodnan skin score (mRSS). METHODS: Limited (lSSc, n = 76) and diffuse SSc (dSSc, n = 41) fulfilling the ACR/EULAR 1980 and 2013 classification criteria for SSc and asymptomatic controls (n = 9) were included. PRO-C1, PRO-C3, and PRO-C6 were measured in serum. RESULTS: LSSc compared to dSSc were significantly older, had longer disease duration and lower mRSS. PRO-C3 was high...
Source: Biomarkers - March 5, 2019 Category: Research Tags: Biomarkers Source Type: research

Elevated homocysteine level and prognosis in patients with acute coronary syndrome: A meta-analysis.
CONCLUSIONS: Elevated homocysteine level was associated with an increased risk of MACE and all-cause mortality among ACS patients. However, the association of elevated homocysteine level with cardiovascular mortality in ACS patients should be further confirmed in future studies. PMID: 30821522 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - March 5, 2019 Category: Research Tags: Biomarkers Source Type: research

Circulating fatty acids as biomarkers of dairy fat intake: Data from the Lifelines Biobank and Cohort Study.
CONCLUSION: Trans-C18:1(n-7) and CLA can be used as biomarkers of dairy fat intake. Additionally, combining established with less established markers allowed even stronger predictions for dairy fat intake. PMID: 30773031 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - February 20, 2019 Category: Research Tags: Biomarkers Source Type: research

Prognostic Value of RASSF1A Methylation Status in Non-Small Cell Lung Cancer (NSCLC) Patients: A Meta-Analysis of Prospective Studies.
Conclusion RASSF1A methylation in lung cancer tissue can serve as a prognostic factor of NSCLC. More studies are needed to uncover the underlying mechanisms. PMID: 30764677 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - February 17, 2019 Category: Research Tags: Biomarkers Source Type: research

Bronchoalveolar Fluid and Plasma Inflammatory Biomarkers in Contemporary ARDS Patients.
CONCLUSIONS: Baseline biomarker levels in current ARDS patients are substantially lower than 6-20 years before collection of these samples. These findings, whether from ICU care changes resulting in less inflammation or from variation in assay techniques over time, have important implications for design of future RCTs with biomarkers as endpoints. PMID: 30744430 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - February 14, 2019 Category: Research Tags: Biomarkers Source Type: research

Insights into Cardiovascular Risk and Nutritional Status in Subjects with Wheat-related Disorders.
CONCLUSION: Subjects with positive serology for Wheat Zoomer have deranged blood lipid profiles but did not show any significant micronutrient deficiency. Hence, our results showcase a significant association of wheat-related disorders to cardiovascular risk. PMID: 30734586 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - February 10, 2019 Category: Research Tags: Biomarkers Source Type: research

Prediction of Alzheimer's disease with serum lipid levels in Asian individuals: A meta-analysis.
CONCLUSIONS: This study provided evidence that serum LDL-C and TC levels were associated with the risk of AD in Asian individuals. The routine lipid profile may be useful for Alzheimer's disease (AD) diagnosis, monitoring and treatment. PMID: 30663433 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - January 22, 2019 Category: Research Tags: Biomarkers Source Type: research

High-Sensitivity Troponin T in Asymptomatic Severe Aortic Stenosis.
Authors: Ferrer-Sistach E, Lupón J, Cediel G, Teis A, Gual F, Serrano S, Vallejo N, Juncà G, López-Ayerbe J, Bayés-Genís A Abstract Background-In asymptomatic severe aortic stenosis (ASAS), treatment decisions are made on an individual basis, and case management presents a clinical conundrum Methods-We prospectively phenotyped consecutive patients with ASAS using echocardiography, exercise echocardiography, cardiac MRI, and biomarkers (NT-proBNP, high-sensitivity troponin T (hs-TnT), and ST2) (n = 58). The primary endpoint was a composite of cardiovascular death, new...
Source: Biomarkers - January 12, 2019 Category: Research Tags: Biomarkers Source Type: research

Circulating nitric oxide metabolites and the risk of cardiometabolic outcomes: A prospective population-based study.
CONCLUSION: In this prospective population-based investigation, a higher circulating NOx was associated with development of MetS. PMID: 30624084 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - January 11, 2019 Category: Research Tags: Biomarkers Source Type: research

How many copies of GSTM1 and GSTT1 are associated with head and neck cancer risk?
CONCLUSION: One copy number of GSTM1 and GSTT1 presented a higher frequency among carrier genes, but the CNV of GSTM1 and GSTT1 was not associated with HNC risk. PMID: 30526121 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - December 14, 2018 Category: Research Tags: Biomarkers Source Type: research

Urine Catecholamines in Children with Severe Enterovirus A71 infection: Comparison with Paediatric Septic Shock.
CONCLUSIONS: The significantly elevated urine catecholamine concentrations in EV-A71-stage-4 patients support the hypothesis that hypercatecholaminemia-related heart failure is involved in severe EV-A71 infection. Urine catecholamines could be used as reliable biomarkers for differentiation of severe EV-A71 infection with or without heart failure and septic shock. PMID: 30521401 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - December 8, 2018 Category: Research Tags: Biomarkers Source Type: research

Pulicaria crispa mitigates gastric ulcer induced by ethanol in rats: Role of treatment and auto healing.
CONCLUSION: Healing potency of Pulicaria crispa is possibly related to its content of glycosides, coumarins, flavonoids, tannins, sterols and triterpenes. PMID: 30512969 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - December 6, 2018 Category: Research Tags: Biomarkers Source Type: research

sST2 as a Novel Biomarker for the Prediction of In-hospital Mortality after Coronary Artery Bypass Grafting.
CONCLUSION: sST2 values are associated with in-hospital mortality after CABG surgery and postoperative and pre-to-post operative sST2 values improve prediction. Our findings suggest that sST2 can be used as a biomarker to identify adult patients at greatest risk of in-hospital death after CABG surgery. Data availability statement: The data that support the findings of this study are available from the Northern New England Cardiovascular Disease Study Group Biomarker Study. Restrictions apply to the availability of these data, which were used under licence for this study. Data are available with permission from of the North...
Source: Biomarkers - December 6, 2018 Category: Research Tags: Biomarkers Source Type: research

Effect of pesticide exposure on the cholinesterase activity of the occupationally exposed tea garden workers of Northern part of West Bengal, India.
CONCLUSION: The results indicated that the decrease in enzyme activities in tea garden workers was due to mixed pesticides (containing organophosphates) exposure. Age was not found to influence the enzyme activities. However, the gender had little effect on the enzyme activities but the effect was not so prominent. PMID: 30512980 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - December 6, 2018 Category: Research Tags: Biomarkers Source Type: research

Lymphocytes DNA damages and exposure to chlorpyrifos, deltamethrin, penconazole, copper oxicloride.
CONCLUSIONS: TM values higher than the 75° percentile were significantly associated with the exposure to particular insecticides such as chlorpyriphos, deltamethrin and with other pesticides (near the statistical significance). PMID: 30514118 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - December 6, 2018 Category: Research Tags: Biomarkers Source Type: research

The temporal pattern of immune and inflammatory proteins prior to a recurrent coronary event in post-acute coronary syndrome patients.
Authors: Vroegindewey MM, Oemrawsingh RM, Kardys I, Asselbergs FW, van der Harst P, Oude Ophuis AJ, Etienne Cramer G, Maas A, Hong Kie The S, Wardeh AJ, Mouthaan H, Boersma E, Akkerhuis KM Abstract PURPOSE: We assessed the temporal pattern of 29 immune and inflammatory proteins in post-acute coronary syndrome (ACS) patients, prior to the development of recurrent ACS. METHODS: High-frequency blood sampling was performed in 844 patients admitted for ACS during one-year follow-up. We conducted a case-control study on the 45 patients who experienced reACS (cases) and two matched event-free patients (controls) per c...
Source: Biomarkers - December 6, 2018 Category: Research Tags: Biomarkers Source Type: research

New Markers of Cell Migration and Inflammation in Children with Chronic Kidney Disease.
CONCLUSIONS: Systemic inflammation and cell migration are triggered by CKD and additionally aggravated by chronic dialysis, with more evident negative impact of HD than APD. Discrepancies in MCP1, MCSF and neopterin serum concentrations suggest they may serve as new markers of cellular and inflammatory responses in children with CKD. PMID: 30516070 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - December 6, 2018 Category: Research Tags: Biomarkers Source Type: research

Detection and Analysis of Endogenous Polar Volatile Organic Compounds (PVOCs) in Urine for Human Exposome Research.
CONCLUSIONS: Headspace collection with sorbent tubes is an effective method for documenting PVOCs in urine that are otherwise difficult to measure. This methodology can provide probative information regarding biochemical processes and adverse outcome pathways (AOPs) for toxicity testing. PMID: 30475075 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - November 28, 2018 Category: Research Tags: Biomarkers Source Type: research

Citrullinated Vimentin and biglycan protein fingerprints as candidate serological biomarkers for disease activity in systemic sclerosis: A pilot study.
Authors: Siebuhr AS, Juhl P, Bay-Jensen AC, Karsdal MA, Franchimont N, Chavez JC Abstract PURPOSE: Extracellular matrix (ECM) deposition and remodelling in skin and lungs of systemic sclerosis (SSc) subjects lead to release of metabolites/biomarkers into circulation. We investigated if biomarkers of ECM degradation (biglycan and elastin) and macrophage activation (citrullinated vimentin) could identify diffuse SSc (dSSc) subjects from controls and the biomarkers discriminative power. METHODS: DSSc subjects (n = 40) fulfilling the 2013 EULAR/ACR classification criteria were divided in early (
Source: Biomarkers - November 22, 2018 Category: Research Tags: Biomarkers Source Type: research

Combining information from multiple bone turnover markers as diagnostic indices for osteoporosis using support vector machines.
CONCLUSION: Our findings showed that although single BTMs were not sufficient for OP diagnosis, appropriate combinations of multiple BTMs incorporated into the SVM models showed almost perfect agreement with the DXA. PMID: 30442069 [PubMed - as supplied by publisher] (Source: Biomarkers)
Source: Biomarkers - November 19, 2018 Category: Research Tags: Biomarkers Source Type: research