The Emerging World of TCR-T Cell Trials Against Cancer: A Systematic Review.
Abstract T-cell receptor-engineered T-cell therapy and chimeric antigen receptor T-cell therapy are 2 types of adoptive T-cell therapy that genetically modify natural T cells to treat cancers. Although chimeric antigen receptor T-cell therapy has yielded remarkable efficacy for hematological malignancies of the B-cell lineages, most solid tumors fail to respond significantly to chimeric antigen receptor T cells. T-cell receptor-engineered T-cell therapy, on the other hand, has shown unprecedented promise in treating solid tumors and has attracted growing interest. In order to create an unbiased, comprehensive, and...
Source: Technology in Cancer Research and Treatment - January 1, 2019 Category: Cancer & Oncology Authors: Zhang J, Wang L Tags: Technol Cancer Res Treat Source Type: research

Efficacy and Tolerability of CyberKnife Stereotactic Robotic Radiotherapy for Primary or Secondary Orbital Lesions: A Single-Center Retrospective Experience.
CONCLUSION:: This current retrospective series demonstrated that CyberKnife robotic stereotactic radiotherapy is a feasible and tolerable approach for intraorbital lesions. PMID: 30803353 [PubMed - in process] (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - January 1, 2019 Category: Cancer & Oncology Authors: Desideri I, Francolini G, Carta GA, Di Cataldo V, Masi L, Meattini I, Bonomo P, Loi M, Greto D, Visani L, Lo Russo M, Grassi R, Teriaca MA, Garlatti P, Nardi C, Livi L Tags: Technol Cancer Res Treat Source Type: research

MicroRNA-374a Governs Aggressive Cell Behaviors of Glioma by Targeting Prokineticin 2.
Abstract MicroRNA-374a has been abnormally expressed in several cancer types; however, its role in glioma remains unclear. Therefore, we aimed to investigate whether microR-374a participated in the progression of glioma. Expression of microR-374a in glioma cell lines and normal cell line was measured by quantitative real-time polymerase chain reaction. Luciferase reporter assay and Western blot were used to detect the targets of microR-374a. In vitro functional experiments were conducted to investigate the biological role of microR-374a. Low expression of microR-374a was found in glioma cell lines. Prokineticin 2 ...
Source: Technology in Cancer Research and Treatment - January 1, 2019 Category: Cancer & Oncology Authors: Zhang Y, Zhang R, Sui R, Chen Y, Liang H, Shi J, Piao H Tags: Technol Cancer Res Treat Source Type: research

Enhancing Effect of 100.414-kHz Electromagnetic Field Produced by Defender's Pulse Generator on the ChIFN γ-Like Molecule Inducing Capacity of Lens culinaris Agglutinin and 10% PBS Washouts of Different Holocene Minerals.
In this study, we have shown that the electromagnetic field of 100.414 kHz is the most effective in inducing synthesis of chicken interferon γ and chicken interferon γ-like molecules in CoMA cells, especially when combined with Lens culinaris agglutinin and 10% phosphate-buffered saline washouts of different Holocene minerals. A 2-minute pulse of electromagnetic field was produced by Defender's pulse generator. Both chicken interferon γ and chicken interferon γ-like molecules from the cell supernatant were evaluated by an antiviral assay and were also analyzed with reverse-phase high-performance liq...
Source: Technology in Cancer Research and Treatment - January 1, 2019 Category: Cancer & Oncology Authors: Filipič B, Rihar K, Gregorič DE, Gradišnik L, Pereyra A, Đermić D, Daničić Č, Mazija H Tags: Technol Cancer Res Treat Source Type: research

lncINS-IGF2 Promotes Cell Proliferation and Migration by Promoting G1/S Transition in Lung Cancer.
Abstract Long noncoding RNAs are capable of regulating gene expression at multiple levels. These RNA molecules are also involved in a variety of physiological and pathological processes. Emerging data demonstrate that a series of differentially expressed long noncoding RNAs are implicated in tumorigenesis. In the present study, we used microarray analysis to identify long noncoding RNAs that are dysregulated in non-small-cell lung cancer when compared to normal lung tissues. Accordingly, we performed quantitative real-time polymerase chain reaction to analyze the levels of long noncoding RNA and the cis target gen...
Source: Technology in Cancer Research and Treatment - January 1, 2019 Category: Cancer & Oncology Authors: Gao S, Lin Z, Li C, Wang Y, Yang L, Zou B, Chen J, Li J, Feng D, Song Z, Liu G Tags: Technol Cancer Res Treat Source Type: research

The Characteristics of Blue Laser Imaging and the Application in Diagnosis of Early Digestive Tract Cancer.
This article reviewed the application of blue laser imaging in diagnosis of early gastrointestinal carcinoma. PMID: 30803360 [PubMed - in process] (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - January 1, 2019 Category: Cancer & Oncology Authors: Bi Y, Min M, Zhang F, Li X Tags: Technol Cancer Res Treat Source Type: research

Prognostic Role of Tenascin-C for Cancer Outcome: A Meta-Analysis.
Abstract BACKGROUND:: The prognostic value of tenascin-C in different types of cancers remains controversial. To clarify its prognostic value on overall survival rates, we have conducted a meta-analysis to quantitatively assess the prognostic roles of tenascin-C for patients with cancer. METHODS:: We systematically searched all published studies about the role of tenascin-C in cancers on PubMed, Web of Science, Cochrane Library, and Embase. The pooled hazard ratio with 95% confidence intervals was used to analyze the association between tenascin-C expression level and overall survival of patients with cancer....
Source: Technology in Cancer Research and Treatment - January 1, 2019 Category: Cancer & Oncology Authors: Ming X, Qiu S, Liu X, Li S, Wang Y, Zhu M, Li N, Luo P, Liang C, Tu J Tags: Technol Cancer Res Treat Source Type: research

Renal Cancer is Not Radioresistant: Slowly but Continuing Shrinkage of the Tumor After Stereotactic Body Radiation Therapy.
CONCLUSION:: All renal tumors decreased in size slowly but continuously for years after stereotactic body radiation therapy. Renal cancer can be treated radically with stereotactic body radiation therapy as a radiosensitive tumor, but careful attention should be given in cases with solitary kidney. PMID: 30803362 [PubMed - in process] (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - January 1, 2019 Category: Cancer & Oncology Authors: Funayama S, Onishi H, Kuriyama K, Komiyama T, Marino K, Araya M, Saito R, Aoki S, Maehata Y, Nonaka H, Tominaga L, Muramatsu J, Nakagomi H, Kamiyama M, Takeda M Tags: Technol Cancer Res Treat Source Type: research

A Noninvasive Method to Reduce Radiotherapy Positioning Error Caused by Respiration for Patients With Abdominal or Pelvic Cancers.
Abstract PURPOSE:: To develop an infrared optical method of reducing surface-based registration error caused by respiration to improve radiotherapy setup accuracy for patients with abdominal or pelvic tumors. MATERIALS AND METHODS:: Fifteen patients with abdominal or pelvic tumors who received radiation therapy were prospectively included in our study. All patients were immobilized with vacuum cushion and underwent cone-beam computed tomography to validate positioning error before treatment. For each patient, after his or her setup based on markers fixed on immobilization device, initial positioning errors in...
Source: Technology in Cancer Research and Treatment - January 1, 2019 Category: Cancer & Oncology Authors: Li W, Jiang Z, Chu K, Jin J, Ge Y, Cai J Tags: Technol Cancer Res Treat Source Type: research

Feasibility of Image Registration for Ultrasound-Guided Prostate Radiotherapy Based on Similarity Measurement by a Convolutional Neural Network.
CONCLUSION:: Convolutional neural network evaluation against manual registration and an advanced normalized correlation -based registration demonstrated better accuracy and reliability of the convolutional neural network. This suggests that with training on a large data set of transperineal ultrasound prostate images, the convolutional neural network method has potential for robust ultrasound-to-ultrasound registration. PMID: 30803364 [PubMed - in process] (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - January 1, 2019 Category: Cancer & Oncology Authors: Zhu N, Najafi M, Han B, Hancock S, Hristov D Tags: Technol Cancer Res Treat Source Type: research

Computer-Aided Diagnosis of Pancreas Serous Cystic Neoplasms: A Radiomics Method on Preoperative MDCT Images.
CONCLUSION:: The proposed radiomics-based computer-aided diagnosis scheme could increase preoperative diagnostic accuracy and assist clinicians in making accurate management decisions. PMID: 30803366 [PubMed - in process] (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - January 1, 2019 Category: Cancer & Oncology Authors: Wei R, Lin K, Yan W, Guo Y, Wang Y, Li J, Zhu J Tags: Technol Cancer Res Treat Source Type: research

Evaluation and Clinical Application of a Commercially Available Iterative Reconstruction Algorithm for CBCT-Based IGRT.
CONCLUSION:: Noise and contrast-to-noise ratio image quality characteristics were significantly improved using the iterative cone-beam computed tomography reconstruction algorithm relative to the filtered back-projection-based cone-beam computed tomography method. These improvements will enhance the accuracy of cone-beam computed tomography-based image-guided applications. PMID: 30803367 [PubMed - in process] (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - January 1, 2019 Category: Cancer & Oncology Authors: Mao W, Liu C, Gardner SJ, Siddiqui F, Snyder KC, Kumarasiri A, Zhao B, Kim J, Wen NW, Movsas B, Chetty IJ Tags: Technol Cancer Res Treat Source Type: research

Preoperative Volumetric Modulated Arc Therapy With Simultaneous Integrated Boost for Locally Advanced Distal Rectal Cancer.
In conclusion, the chemoradiation regimen of preoperative volumetric modulated arc therapy-simultaneous integrated boost (VMAT-SIB58.75Gy) and a single cycle of induction chemotherapy with capecitabine for patients with distal rectal cancer is safe and feasible with a satisfactory complete pathological response rate, sphincter preservation rate, and R0 resection rate. PMID: 30803368 [PubMed - in process] (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - January 1, 2019 Category: Cancer & Oncology Authors: Yang Y, Liu Q, Jia B, Du X, Dai G, Liu H, Chen J, Zeng M, Wen K, Zhu Y, Wang Y, Feng L Tags: Technol Cancer Res Treat Source Type: research

Integrated Analysis of Transcriptome and Prognosis Data Identifies FGF22 as a Prognostic Marker of Lung Adenocarcinoma.
This study aimed to investigate the expression profiles of anti-lung cancer target genes in different cancer stages and to explore their functions in tumor development. Lung adenocarcinoma transcriptome and clinical data were downloaded from Genomic Data Commons Data Portal, and the anti-lung cancer target genes were retrieved from the Thomson Reuters Integrity database. The results showed that 16 anti-lung target genes were deregulated in all stages. Among these target genes, fibroblast growth factor 22 showed the most important role in transcription regulatory networks. Further analysis revealed that APC, BRIP1, and PTTG...
Source: Technology in Cancer Research and Treatment - January 1, 2019 Category: Cancer & Oncology Authors: Liu HY, Zhao H, Li WX Tags: Technol Cancer Res Treat Source Type: research

MicroRNA-132 Plays an Independent Prognostic Role in Pancreatic Ductal Adenocarcinoma and Acts as a Tumor Suppressor.
Abstract The role of microRNA-132 in human pancreatic ductal adenocarcinomas is still ambiguous. We explored the association between microRNA-132 and pancreatic ductal adenocarcinoma prognosis. The expression of microRNA-132 in 50 pancreatic ductal adenocarcinoma tissue samples and pancreatic ductal adenocarcinoma cell lines was examined, and the association between its expression and pancreatic ductal adenocarcinoma prognosis was assessed. Functional analysis and factors downstream of microRNA-132 were investigated. Kaplan-Meier survival curves showed that high expression of microRNA-132 was a significant prognos...
Source: Technology in Cancer Research and Treatment - January 1, 2019 Category: Cancer & Oncology Authors: Chen Y, Zhu H, Wang Y, Song Y, Zhang P, Wang Z, Gao J, Li Z, Du Y Tags: Technol Cancer Res Treat Source Type: research

The Dosimetric and Temporal Effects of Respiratory-Gated, High-Dose-Rate Radiation Therapy in Patients With Lung Cancer.
CONCLUSION:: Respiratory-gated radiation therapy in patients with lung cancer can reduce lung dose while maintaining tumor dose. Because treatment delivery during gated therapy is discontinuous, total treatment time may be prolonged. However, this increase in treatment time can be offset by increasing the dose delivery rate. Estimation of treatment time may be helpful in selecting patients for respiratory gating and choosing appropriate gating windows. PMID: 30803374 [PubMed - in process] (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - January 1, 2019 Category: Cancer & Oncology Authors: Rouabhi O, Gross B, Bayouth J, Xia J Tags: Technol Cancer Res Treat Source Type: research

Effect of Deformation Methods on the Accuracy of Deformable Image Registration From Kilovoltage CT to Tomotherapy Megavoltage CT.
CONCLUSIONS:: The choice of deformation method should be considered when applying the deformable image registration from kilovoltage to megavoltage images. The deformable image registration accuracy from kilovoltage to megavoltage revealed a good agreement in terms of intensity-based, volume-based, and deformation field analyses and showed clinically useful methods for nasopharyngeal carcinoma adaptive radiotherapy in tomotherapy applications. PMID: 30803375 [PubMed - in process] (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - January 1, 2019 Category: Cancer & Oncology Authors: Nobnop W, Chitapanarux I, Wanwilairat S, Tharavichitkul E, Lorvidhaya V, Sripan P Tags: Technol Cancer Res Treat Source Type: research

Laparoscopic Microwave Ablation of Hepatocellular Carcinoma at Liver Surface: Technique Effectiveness and Long-Term Outcomes.
CONCLUSIONS:: As a first-line treatment, laparoscopic microwave ablation provides high technique effectiveness rate and is well tolerated in patients with hepatocellular carcinoma located at liver surface. Alanine transaminase and tumor number were significant predictors of recurrence-free survival, whereas α-fetoprotein level was significant predictor of overall survival. Laparoscopic microwave ablation might serve as a rational treatment option for patients with hepatocellular carcinoma with tumors at the liver surface, which merits validation in future perspective studies. PMID: 30803390 [PubMed - in process]...
Source: Technology in Cancer Research and Treatment - January 1, 2019 Category: Cancer & Oncology Authors: Wang T, Zhang XY, Lu X, Zhai B Tags: Technol Cancer Res Treat Source Type: research

Intraoperative Assessment of Sentinel Lymph Nodes in Breast Cancer Patients Post-Neoadjuvant Therapy.
CONCLUSION:: Sentinel lymph node frozen section diagnosis post-neoadjuvant therapy has comparable sensitivity, specificity, and accuracy to the sentinel lymph node frozen section diagnosis in the non-neoadjuvant therapy setting. PMID: 30803394 [PubMed - in process] (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - January 1, 2019 Category: Cancer & Oncology Authors: Wong W, Rubenchik I, Nofech-Mozes S, Slodkowska E, Parra-Herran C, Hanna WM, Lu FI Tags: Technol Cancer Res Treat Source Type: research

Permanent Iodine-125 Seed Implantation for the Treatment of Nonresectable Retroperitoneal Malignant Tumors.
CONCLUSIONS:: 125I implantation could effectively relieve the pain in the patients with advanced primary or metastatic retroperitoneal malignant tumors and suppress local tumor progress. PMID: 30803402 [PubMed - in process] (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - January 1, 2019 Category: Cancer & Oncology Authors: Li Q, Tian Y, Yang D, Liang Y, Cheng X, Gai B Tags: Technol Cancer Res Treat Source Type: research

Plasma microRNAs Predict Chemoresistance in Patients With Metastatic Breast Cancer.
CONCLUSIONS: Plasma miR-200a and miR-210 could be effective biomarkers for the prediction of chemotherapy resistance in metastatic breast cancer patients. PMID: 30786836 [PubMed - in process] (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - January 1, 2019 Category: Cancer & Oncology Authors: Shao B, Wang X, Zhang L, Li D, Liu X, Song G, Cao H, Zhu J, Li H Tags: Technol Cancer Res Treat Source Type: research

Does Interfraction Cone Beam Computed Tomography Improve Target Localization in Prostate Bed Radiotherapy?
CONCLUSION:: We prospectively demonstrated that the daily use of volumetric cone beam computed tomography for treatment localization in post-radical prostatectomy patients demonstrated an increased need for a shift in patient position. This suggests that in post-radical prostatectomy patients the daily cone beam computed tomography imaging improved localization of the prostate bed and may have prevented a limited number of geographic misses, compared to daily kilovoltage imaging that was not assisted with fiducials. PMID: 30782085 [PubMed - in process] (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - January 1, 2019 Category: Cancer & Oncology Authors: Elakshar S, James MGT, Michael JK, Tomic N, Fawaz ZS, Bahoric B, Papayanatos J, Chaddad A, Niazi T Tags: Technol Cancer Res Treat Source Type: research

Classification of Thyroid Nodules in Ultrasound Images Using Direction-Independent Features Extracted by Two-Threshold Binary Decomposition.
Abstract In recent years, several computer-aided diagnosis systems emerged for the diagnosis of thyroid gland disorders using ultrasound imaging. These systems based on machine learning algorithms may offer a second opinion to radiologists by evaluating a malignancy risk of thyroid tissue, thus increasing the overall diagnostic accuracy of ultrasound imaging. Although current computer-aided diagnosis systems exhibit promising results, their use in clinical practice is limited. One of the main limitations is that the majority of them use direction-dependent features. Our intention has been to design a computer-aide...
Source: Technology in Cancer Research and Treatment - January 1, 2019 Category: Cancer & Oncology Authors: Prochazka A, Gulati S, Holinka S, Smutek D Tags: Technol Cancer Res Treat Source Type: research

Effect of Source-Detector Distance on the Measurement of Hemoglobin Using Near-Infrared Spectroscopy in Breast Cancer.
In conclusion, using a probe with a source-detector distance of 20 mm can more accurately evaluate the total hemoglobin concentration in breast tumors. PMID: 30764728 [PubMed - in process] (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - January 1, 2019 Category: Cancer & Oncology Authors: Hayashi M, Yoshizawa N, Ueda Y, Mimura T, Ohmae E, Yoshimoto K, Wada H, Nasu H, Ogura H, Sakahara H Tags: Technol Cancer Res Treat Source Type: research

64Cu-based Radiopharmaceuticals in Molecular Imaging.
Abstract Copper-64 (T1/2 = 12.7 hours; β+: 19%, β-: 38%) has a unique decay profile and can be used for positron emission tomography imaging and radionuclide therapy. The well-established coordination chemistry of copper allows for its reaction with different types of chelator systems. It can be linked to antibodies, proteins, peptides, and other biologically relevant small molecules. Two potential ways to produce copper-64 radioisotopes concern the use of the cyclotron or the reactor. This review summarized several commonly used biomarkers of copper-64 radionuclide. PMID: 30764737 [PubMed - in proc...
Source: Technology in Cancer Research and Treatment - January 1, 2019 Category: Cancer & Oncology Authors: Zhou Y, Li J, Xu X, Zhao M, Zhang B, Deng S, Wu Y Tags: Technol Cancer Res Treat Source Type: research

Peripheral Venous Blood Platelet-to-Lymphocyte Ratio (PLR) for Predicting the Survival of Patients With Gastric Cancer Treated With SOX or XELOX Regimen Neoadjuvant Chemotherapy.
Abstract BACKGROUND:: Inflammation plays an important role in tumor progression. Predicting survival is remarkably difficult in patients with gastric cancer receiving neoadjuvant chemotherapy. The aim of the present study is to investigate the potential prognostic significance of the platelet-to-lymphocyte ratio in patients with gastric cancer receiving S-1 plus oxaliplatin or oxaliplatin and capecitabine regimen. METHODS:: Ninety-one patients with gastric cancer treated with neoadjuvant chemotherapy were enrolled in this study and then underwent operation. The optimal cutoff value was calculated using receiv...
Source: Technology in Cancer Research and Treatment - January 1, 2019 Category: Cancer & Oncology Authors: Chen L, Hao Y, Cong X, Zou M, Li S, Zhu L, Song H, Xue Y Tags: Technol Cancer Res Treat Source Type: research

Exosomes: A Promising Avenue for the Diagnosis of Breast Cancer.
Abstract Currently, despite the advances in individualized treatment, breast cancer still remains the deadliest form of cancer in women. Diagnostic, prognostic, and therapy-predictive methods are mainly based on the evaluation of tumor tissue samples and are aimed to improve the overall therapeutic level. Therefore, the exploration of a series of circulating biomarkers, which serve as the information source of tumors and could be obtained by peripheral blood samples, represents a high field of interest. Apart from classical biomarkers, exosomes, which are nanovesicles, are emerging as an accessible and efficient s...
Source: Technology in Cancer Research and Treatment - January 1, 2019 Category: Cancer & Oncology Authors: Meng Y, Sun J, Wang X, Hu T, Ma Y, Kong C, Piao H, Yu T, Zhang G Tags: Technol Cancer Res Treat Source Type: research

MicroRNA-143 is Associated With Pathological Complete Response and Regulates Multiple Signaling Proteins in Breast Cancer.
Ramos-Payán R, Aguilar-Medina M, López-Camarillo C Abstract Almost 55% to 80% of patients with breast cancer have an unfavorable pathological complete response to chemotherapy. MicroRNAs are small noncoding RNAs involved in cancer progression; however, their utility as predictors of pathological complete response to neoadjuvant chemotherapy is unclear. Here, we investigated if miR-143 could discriminate between pathological complete response and no-polymerase chain reaction of patients with locally advanced triple negative breast cancer that have received a fluorouracil-cisplatin/paclitaxel-based ne...
Source: Technology in Cancer Research and Treatment - January 1, 2019 Category: Cancer & Oncology Authors: García-Vázquez R, Marchat LA, Ruíz-García E, Astudillo-de la Vega H, Meneses-García A, Arce-Salinas C, Bargallo-Rocha E, Carlos-Reyes Á, López-González JS, Pérez-Plasencia C, Ramos-Payán R, Aguilar-Medina M, López-Camarillo C Tags: Technol Cancer Res Treat Source Type: research

SLC25A22 Promotes Proliferation and Metastasis of Osteosarcoma Cells via the PTEN Signaling Pathway.
This study highlights the causal link between solute carrier family 25 member 22 (SLC25A22) and the development, progression, and metastasis of osteosarcoma. SLC25A22 is upregulated in human osteosarcoma and predicts a poor prognosis. The upregulation of SLC25A22 in osteosarcoma tissues was significantly associated with cell proliferation, invasion, and metastasis. Studies of functional gain (overexpression) and loss (knockdown) showed that SLC25A22 significantly increases the ability of osteosarcoma cells to proliferate, as well as invade and metastasize in vitro. At the same time, the expression of SLC25A22 promoted the ...
Source: Technology in Cancer Research and Treatment - January 1, 2018 Category: Cancer & Oncology Authors: Chen MW, Wu XJ Tags: Technol Cancer Res Treat Source Type: research

Identification of miR-758-3p as Potential Modulator of CBX5 Expression in Gastric Cancer.
In this study, we revealed that chromobox 5 could promote gastric cancer cell proliferation, migration, and invasion in vitro. We screened and identified microRNA-758-3p, whose expression was downregulated in gastric cancer tissues and cell lines, which was a potential upstream molecule of chromobox 5. Upregulation of microRNA-758-3p could markedly downregulate the expression of chromobox 5. Additionally, expression of microRNA-758-3p and chromobox 5 was inversely correlated in gastric cancer tissues. Moreover, microRNA-758-3p overexpression suppressed gastric cancer cell proliferation, migration, and invasion, but these e...
Source: Technology in Cancer Research and Treatment - January 1, 2018 Category: Cancer & Oncology Authors: Guo J, Zhang Z, Pan L, Zhou Y Tags: Technol Cancer Res Treat Source Type: research

Optical Surface Scanning for Patient Positioning in Radiation Therapy: A Prospective Analysis of 1902 Fractions.
CONCLUSION:: The optical surface scanner Catalyst HD is a reliable and feasible patient positioning system without any additional radiation exposure. From the head to the thoracic and abdominal region, a decrease in accuracy was observed within a comparable range for Catalyst and laser-assisted positioning. PMID: 30453842 [PubMed - in process] (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - January 1, 2018 Category: Cancer & Oncology Authors: Carl G, Reitz D, Schönecker S, Pazos M, Freislederer P, Reiner M, Alongi F, Niyazi M, Ganswindt U, Belka C, Corradini S Tags: Technol Cancer Res Treat Source Type: research

MicroRNA Regulation of Energy Metabolism to Induce Chemoresistance in Cancers.
Abstract Since "Warburg effect" has been firstly uncovered in cancer cells in 1956, mounting evidence has supported the molecular mechanism underlying the energy metabolism in induced chemoresistance in cancers. MicroRNAs can mediate fine-tuning of genes in physiological process. MicroRNAs' energy metabolic role in chemoresistance has been probed recently. In this review, we summarize 5 microRNAs in regulating glucose and lipid metabolism and other energy metabolism. They partially modulate chemoresistance to cancer treatments. Furthermore, we discuss the great therapeutic potential of metabolism-related...
Source: Technology in Cancer Research and Treatment - January 1, 2018 Category: Cancer & Oncology Authors: Ye J, Zou M, Li P, Liu H Tags: Technol Cancer Res Treat Source Type: research

Salvage Pulmonary Operations Following Stereotactic Body Radiotherapy for Small Primary and Metastatic Lung Tumors: Evaluation of the Operative Procedures.
This study aimed to assess the difficulty associated with salvage operative procedures. Eight patients who developed local relapse after stereotactic body radiotherapy and had undergone salvage pulmonary operations were enrolled in this study (stereotactic body radiotherapy group). Additionally, 439 patients who underwent video-assisted thoracoscopic lobectomy without previous stereotactic body radiotherapy were enrolled as the standard operative control group (non-stereotactic body radiotherapy group). In the stereotactic body radiotherapy group, 1 of the 8 patients had undergone lobectomy with composite resection of the ...
Source: Technology in Cancer Research and Treatment - January 1, 2018 Category: Cancer & Oncology Authors: Hamakawa H, Takahashi Y, Sakanoue I, Saito T, Date N, Tomii K, Katakami N, Imagunbai T, Kokubo M Tags: Technol Cancer Res Treat Source Type: research

Prognostic Value of Mismatch Repair Genes for Patients With Colorectal Cancer: Meta-Analysis.
Abstract DNA mismatch repair was proposed to play a pivotal role in the development and prognosis of colorectal cancer. However, the prognostic value of mismatch repair on colorectal cancer is still unknown. The PubMed, EMBASE, and Cochrane Central Register of Controlled Trials databases were searched. The articles about mismatch repair (including hMLH1, hMSH2, hMSH3, hMSH6, hPMSH1, and hPMSH2) deficiency for the prognosis of patients with colorectal cancer were included in the study. The hazard ratio and its 95% confidence interval were used to measure the impact of mismatch repair deficiency on survival time. Tw...
Source: Technology in Cancer Research and Treatment - January 1, 2018 Category: Cancer & Oncology Authors: Hou JT, Zhao LN, Zhang DJ, Lv DY, He WL, Chen B, Li HB, Li PR, Chen LZ, Chen XL Tags: Technol Cancer Res Treat Source Type: research

Performance Comparison of Knowledge-Based Dose Prediction Techniques Based on Limited Patient Data.
CONCLUSION:: Compared with more sophisticated parametric machine learning methods with dimension reduction, statistical voxel dose learning is more robust to patient variability and provides the most accurate dose prediction method. PMID: 30411666 [PubMed - in process] (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - January 1, 2018 Category: Cancer & Oncology Authors: Landers A, Neph R, Scalzo F, Ruan D, Sheng K Tags: Technol Cancer Res Treat Source Type: research

Electroporation of the Liver: More Than 2 Concurrently Active, Curved Electrodes Allow New Concepts for Irreversible Electroporation and Electrochemotherapy.
Abstract Irreversible electroporation and electrochemotherapy are 2 innovative electroporation-based minimally invasive therapies for the treatment of cancer. Combining nonthermal effects of irreversible electroporation with local application of chemotherapy, electrochemotherapy is an established treatment modality for skin malignancies. Since the application of electrochemotherapy in solid organs is a promising approach, this article describes a novel electrode configuration and field generating method. For the treatment of hepatic malignancies, the shape of the electric field should resemble a spherical 3-dimens...
Source: Technology in Cancer Research and Treatment - January 1, 2018 Category: Cancer & Oncology Authors: Ritter A, Bruners P, Isfort P, Barabasch A, Pfeffer J, Schmitz J, Pedersoli F, Baumann M Tags: Technol Cancer Res Treat Source Type: research

Clinicopathologic Analysis of Oral Squamous Cell Carcinoma After 125I Interstitial Brachytherapy.
This study focused on the pathologic characteristics of the patients with oral squamous cell carcinoma who underwent seed implantation after radical surgery, and the relationship of these characteristics with prognosis. Thus, 76 patients with oral squamous cell carcinoma, who were treated with surgery and subsequently with iodine 125 (125I) radioactive seed implantation, were recruited in this study. We summarized the demographic information, tumor size, location, clinical stage, prognosis, and pathologic characteristics, and discussed the correlations between prognosis and histologic features of oral squamous cell carcino...
Source: Technology in Cancer Research and Treatment - January 1, 2018 Category: Cancer & Oncology Authors: Jie WP, Bai JY, Li BB Tags: Technol Cancer Res Treat Source Type: research

Real-Time Tumor-Tracking Radiotherapy and General Stereotactic Body Radiotherapy for Adrenal Metastasis in Patients With Oligometastasis.
Abstract BACKGROUND:: Precise local radiotherapy for adrenal metastasis can prolong the useful life of patients with oligometastasis. The aim of this retrospective, 2-center study was to establish the safety and effectiveness of real-time tumor-tracking radiotherapy and general stereotactic body radiotherapy in treating patients with adrenal metastatic tumors. MATERIALS AND METHODS:: Thirteen lesions in 12 patients were treated with real-time tumor-tracking radiotherapy (48 Gy in 8 fractions over 2 weeks) and 8 lesions in 8 patients were treated with general stereotactic body radiotherapy (40-50 Gy in 5-8 fra...
Source: Technology in Cancer Research and Treatment - January 1, 2018 Category: Cancer & Oncology Authors: Katoh N, Onishi H, Uchinami Y, Inoue T, Kuriyama K, Nishioka K, Shimizu S, Komiyama T, Miyamoto N, Shirato H Tags: Technol Cancer Res Treat Source Type: research

Automated Field-In-Field (FIF) Plan Framework Combining Scripting Application Programming Interface and User-Executed Program for Breast Forward IMRT.
CONCLUSION:: The combination of scripting applications and user-executed programming for automated breast field-in-field planning accomplished a significant enhancement in planning efficiency without degrading the plan quality, relative to the manual field-in-field procedure. PMID: 30384804 [PubMed - in process] (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - January 1, 2018 Category: Cancer & Oncology Authors: Kim H, Kwak J, Jung J, Jeong C, Yoon K, Lee SW, Ahn SD, Choi EK, Kim SS, Cho B Tags: Technol Cancer Res Treat Source Type: research

MicroRNA-22 Suppresses Breast Cancer Cell Growth and Increases Paclitaxel Sensitivity by Targeting NRAS.
Abstract In recent study, microRNAs have various important functions in diverse biological processes and progression of cancer. In human breast cancer, microRNA-22 has been reported to be downregulated. However, molecular mechanism of microRNA-22 in breast cancer progression and chemosensitivity has not been well studied. In our study, these results demonstrated that microRNA-22 expression levels were significantly reduced in 40 pairs of human breast cancer tissues when compared to normal tissues. Enforced expression of microRNA-22 inhibited activity of cell proliferation and cell migration in breast cancer cells....
Source: Technology in Cancer Research and Treatment - January 1, 2018 Category: Cancer & Oncology Authors: Song YK, Wang Y, Wen YY, Zhao P, Bian ZJ Tags: Technol Cancer Res Treat Source Type: research

Nicotine Induces Progressive Properties of Lung Adenocarcinoma A549 Cells by Inhibiting Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Expression and Plasma Membrane Localization.
This study thus suggests that cystic fibrosis transmembrane conductance regulator may play a tumor suppressor role in lung cancer cells, which may be a novel therapeutic target warranted for further investigation. PMID: 30384810 [PubMed - in process] (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - January 1, 2018 Category: Cancer & Oncology Authors: Li H, Ma N, Wang J, Wang Y, Yuan C, Wu J, Luo M, Yang J, Chen J, Shi J, Liu X Tags: Technol Cancer Res Treat Source Type: research

High BIRC7 Expression Might Be an Independent Prognostic Indicator of Poor Recurrence-Free Survival in Patients With Prostate Cancer.
CONCLUSION:: Based on these findings, we infer that BIRC7 upregulation might serve as a valuable biomarker of increased recurrence risk in advanced T stages and medium-grade prostate cancer. Its expression is at least regulated by both copy number alteration and DNA methylation. PMID: 30376767 [PubMed - in process] (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - January 1, 2018 Category: Cancer & Oncology Authors: Yang Y, Sun P, Xu W, Xia W Tags: Technol Cancer Res Treat Source Type: research

Radiotherapy Immobilization Mask Molding Through the Use of 3D-Printed Head Models.
CONCLUSIONS:: Patient head volumes and positions at simulation computed tomography scans can be accurately reproduced using three-dimensional-printed models, which can be used to mold radiotherapy immobilization masks onto. This strategy, if applied on diagnostic computed tomography scans, may allow symptomatic and frail patients to avoid a computed tomography-simulation and mask molding session in preparation for palliative whole brain radiotherapy. PMID: 30380998 [PubMed - in process] (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - January 1, 2018 Category: Cancer & Oncology Authors: Pham QV, Lavallée AP, Foias A, Roberge D, Mitrou E, Wong P Tags: Technol Cancer Res Treat Source Type: research

Transcutaneous Electrical Acupoint Stimulation Improves Immunological Function During the Perioperative Period in Patients With Non-Small Cell Lung Cancer Undergoing Video-Assisted Thoracic Surgical Lobectomy.
Abstract The immunological function of patients with malignant tumors may be suppressed during the perioperative period. However, details on the effects of transcutaneous electrical acupoint stimulation (TEAS) on immunological function are relatively lacking. We designed this study to examine the effects of TEAS on the immunological function of patients with non-small cell lung cancer (NSCLC) during the perioperative period. Participants (n = 144) were enrolled and randomly assigned into group TEAS or group sham TEAS. TEAS on bilateral Feishu (BL13), Hegu (L14), and Zusanli (ST36) was performed continuously throug...
Source: Technology in Cancer Research and Treatment - January 1, 2018 Category: Cancer & Oncology Authors: Tu Q, Yang Z, Gan J, Zhang J, Que B, Song Q, Wang Y Tags: Technol Cancer Res Treat Source Type: research

MicroRNA-494-3p Promotes Cell Growth, Migration, and Invasion of Nasopharyngeal Carcinoma by Targeting Sox7.
CONCLUSION:: miR-494-3p promotes nasopharyngeal carcinoma cell growth, migration, and invasion by directly targeting Sox7. Our results suggest that miR-494-3p might be a potential therapeutic target for nasopharyngeal carcinoma. PMID: 30381030 [PubMed - in process] (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - January 1, 2018 Category: Cancer & Oncology Authors: He H, Liao X, Yang Q, Liu Y, Peng Y, Zhong H, Yang J, Zhang H, Yu Z, Zuo Y, Guan C, Xu Z Tags: Technol Cancer Res Treat Source Type: research

Compressed Sensing With a Gaussian Scale Mixture Model for Limited View Photoacoustic Computed Tomography In Vivo.
Abstract Photoacoustic computed tomography using an ultrasonic array is an attractive noninvasive imaging modality for many biomedical applications. However, the potentially long data acquisition time of array-based photoacoustic computed tomography-usually due to the required time-multiplexing for multiple laser pulses-decreases its applicability for rapid disease diagnoses and the successive monitoring of physiological functions. Compressed sensing is used to improve the imaging speed of photoacoustic computed tomography by decreasing the amount of acquired data; however, the imaging quality can be limited when ...
Source: Technology in Cancer Research and Treatment - January 1, 2018 Category: Cancer & Oncology Authors: Meng J, Liu C, Kim J, Kim C, Song L Tags: Technol Cancer Res Treat Source Type: research

Stereotactic Radiotherapy for Oligometastases in Lymph Nodes-A Review.
In this study, the usability of stereotactic body radiotherapy for oligometastases to lymph nodes is assessed by researching for each primary site. As a result, we could consider that stereotactic body radiotherapy could be almost well applied for lymph node oligometastases from the breast, gynecological organs, and prostate. However, doubts remain concerning the usefulness of stereotactic body radiotherapy for cervical node metastases from head and neck cancer or for mediastinal node metastases from lung or esophageal cancer since late toxicities have occurred with a large radiation dose at hypofractionation to major vess...
Source: Technology in Cancer Research and Treatment - January 1, 2018 Category: Cancer & Oncology Authors: Matsushita H, Jingu K, Umezawa R, Yamamoto T, Ishikawa Y, Takahashi N, Katagiri Y, Kadoya N Tags: Technol Cancer Res Treat Source Type: research

Stereotactic Body Radiotherapy for Spinal Metastases: Clinical Experience in 134 Cases From a Single Japanese Institution.
This study aimed to clarify the outcomes of stereotactic body radiotherapy for spinal metastases with a uniform dose fractionation schedule in our institution. MATERIALS AND METHODS:: Patients treated with spine stereotactic body radiotherapy were retrospectively reviewed. The prescribed dose was 24 Gy in 2 fractions. End points were local control, pain control, and adverse events. Local control was defined as elimination, shrinkage, or stable disease in the tumor on imaging evaluations. Pain status was measured on a scale of 0 to 10 by patients' self-reports, and pain response was defined as the time at which pain sc...
Source: Technology in Cancer Research and Treatment - January 1, 2018 Category: Cancer & Oncology Authors: Ito K, Ogawa H, Shimizuguchi T, Nihei K, Furuya T, Tanaka H, Karasawa K Tags: Technol Cancer Res Treat Source Type: research

Deregulation of MicroRNA-375 Inhibits Proliferation and Migration in Gastric Cancer in Association With Autophagy-Mediated AKT/mTOR Signaling Pathways.
In this study, we first analyzed the profiles and prognostic values of miR-375 expression in gastric cancer tissues from a public database, and the expression level of miR-375 in gastric cancer samples and gastric cancer cell lines was then analyzed by quantitative real- time polymerase chain reaction. Significant underexpression of miR-375 was seen in all the gastric cancer samples compared to paired paracarcinoma tissues, and the expression level of miR-375 in the gastric cancer cell lines was negatively associated with the cell migration ability. A Cell proliferation (CCK-8) assay was performed to examine cell viability...
Source: Technology in Cancer Research and Treatment - January 1, 2018 Category: Cancer & Oncology Authors: Yuan KT, Li BX, Yuan YJ, Tan M, Tan JF, Dai WG, Feng WD, Zuo JD Tags: Technol Cancer Res Treat Source Type: research

Image-Based Profiling of Patient-Derived Pancreatic Tumor-Stromal Cell Interactions Within a Micropatterned Tumor Model.
This study demonstrates the ability to engineer tumor-stromal assays with patient-derived cells, study the role of diverse types of stromal cells on cancer progression, and precisely visualize a coculture during the screening of therapeutic compounds. PMID: 30348057 [PubMed - in process] (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - January 1, 2018 Category: Cancer & Oncology Authors: Mukundan S, Sharma K, Honselmann K, Singleton A, Liss A, Parekkadan B Tags: Technol Cancer Res Treat Source Type: research