Noncoplanar Radiation using Tomotherapy: A Phantom Study.
CONCLUSIONS: Noncoplanar radiation on the head region using tomotherapy was possible by using a tilt-type head and neck fixture, and the dose distribution could be evaluated using deformable image registration. This method helps reduce the dose of the organ-at-risk region located slightly away from the planning target volume. PMID: 32734825 [PubMed - in process] (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - January 1, 2020 Category: Cancer & Oncology Authors: Yuasa M, Kurosaki H Tags: Technol Cancer Res Treat Source Type: research

The Changes in Pharyngeal Constrictor Muscles Related to Head and Neck Radiotherapy: A Systematic Review.
Abstract It is well known that radiation damage of the pharyngeal constrictor muscles, the glottic larynx, and the supraglottic larynx may lead to dysphagia, an unwanted effect of head and neck radiotherapy. The reduction of radiotherapy-induced dysphagia might be achieved by adaptive radiotherapy. Although the number of studies concerning adaptive radiotherapy of head and neck cancer is continuously increasing, there are only a few studies concerning changes in dysphagia-related structures during radiotherapy.The goal of this review is to summarize the current knowledge about volumetric, dosimetric, and other cha...
Source: Technology in Cancer Research and Treatment - January 1, 2020 Category: Cancer & Oncology Authors: Grepl J, Sirak I, Vosmik M, Tichy A Tags: Technol Cancer Res Treat Source Type: research

Circular RNA SFMBT2 Inhibits the Proliferation and Metastasis of Glioma Cells Through Mir-182-5p/Mtss1 Pathway.
Abstract Glioma is a common type of tumor in human central nervous system, and it is characterized with high mobility and mortality. The prognosis of patients with advanced glioma remains poor. Thus, it is necessary to develop novel therapeutic approaches for the treatment of this disease. Circular RNAs are a group of noncoding RNAs which have been detected in eukaryotic cells. They are tissue-specific and characterized with a more stable structure compared with linear RNAs. Recently, studies have revealed that certain circular RNAs are involved in biological processes such as gene regulation; however, the functio...
Source: Technology in Cancer Research and Treatment - January 1, 2020 Category: Cancer & Oncology Authors: Zhang S, Qin W, Yang S, Guan N, Sui X, Guo W Tags: Technol Cancer Res Treat Source Type: research

Evaluation of Delta4DVH Anatomy in 3D Patient-Specific IMRT Quality Assurance.
CONCLUSIONS: The new Delta4DVH Anatomy with treatment plan dose measured modification algorithm is a useful tool for the anatomy-based patient-specific quality assurance. Cautions should be taken when using pencil beam algorithm due to its limitations in handling heterogeneity and in high-dose gradient regions. PMID: 32720589 [PubMed - in process] (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - January 1, 2020 Category: Cancer & Oncology Authors: Tang D, Yang Z, Dai X, Cao Y Tags: Technol Cancer Res Treat Source Type: research

Long Noncoding RNA Maternally Expressed Gene 3 Is Downregulated, and Its Insufficiency Correlates With Poor-Risk Stratification, Worse Treatment Response, as Well as Unfavorable Survival Data in Patients With Acute Myeloid Leukemia.
CONCLUSION: Long noncoding RNA maternally expressed gene 3 may function as a novel marker for effective surveillance and management of acute myeloid leukemia. PMID: 32720591 [PubMed - in process] (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - January 1, 2020 Category: Cancer & Oncology Authors: He C, Wang X, Luo J, Ma Y, Yang Z Tags: Technol Cancer Res Treat Source Type: research

Predictive Value of Early Response to Chemoradiotherapy in Advanced Esophageal Squamous Cell Carcinoma by Diffusion-Weighted MR Imaging.
Abstract OBJECTIVE: To explore the value of diffusion-weighted imaging for early response detection of locally advanced esophageal squamous cell carcinoma with concurrent chemoradiotherapy. METHODS: Fifty-five (42 males, 13 females) patients with locally advanced esophageal cancer who were undergoing chemoradiotherapy were recruited for this study. Diffusion-weighted imaging was performed in all patients before therapy, at the first weekend, the second weekend, and the end of chemoradiotherapy. The rate of change in apparent diffusion coefficient value and the maximum diameter between pretherapy and postthera...
Source: Technology in Cancer Research and Treatment - January 1, 2020 Category: Cancer & Oncology Authors: Chen W, Wang YT, Guo L, Zhu Z, Zhou HF, Bai G Tags: Technol Cancer Res Treat Source Type: research

SNHG7 Facilitates Glioblastoma Progression by Functioning as a Molecular Sponge for MicroRNA-449b-5p and Thereby Increasing MYCN Expression.
CONCLUSION: In summary, our results demonstrated that small nucleolar RNA host gene 7 regulates glioblastoma proliferation, migration, and invasion via regulating miR-449b-5p and its target gene MYCN, thereby providing a potential therapeutic target for glioblastoma. PMID: 32720593 [PubMed - in process] (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - January 1, 2020 Category: Cancer & Oncology Authors: Chen Y, Yuan S, Ning T, Xu H, Guan B Tags: Technol Cancer Res Treat Source Type: research

The Clinical Characteristics of Endometrial Cancer With Extraperitoneal Metastasis and the Value of Surgery in Treatment.
Abstract OBJECTIVE: To describe the clinical and pathological features of endometrial carcinoma with extraperitoneal metastasis and examine whether surgery could improve the prognosis. METHODS: The Surveillance, Epidemiology, and End Results database was used to analyze 730 patients who were diagnosed with extraperitoneal metastasis of endometrial cancer from 2010 to 2015, including metastasis to the lung, bone, or brain. RESULTS: Of the 730 patients, 372 (50.96%) patients had single lung metastases, and 196(26.85%) patients had multiple organ metastases that included pulmonary invasion. Therefore, the l...
Source: Technology in Cancer Research and Treatment - January 1, 2020 Category: Cancer & Oncology Authors: Guo J, Cui X, Zhang X, Qian H, Duan H, Zhang Y Tags: Technol Cancer Res Treat Source Type: research

Efficacy of Next-Generation EGFR-TKIs in Patients With Non-Small Cell Lung Cancer: A Meta-Analysis of Randomized Controlled Trials.
Abstract BACKGROUND: The efficacy of next-generation epidermal growth factor receptor-tyrosine kinase inhibitors in patients with advanced non-small cell lung cancer who have failed first-generation epidermal growth factor receptor-tyrosine kinase inhibitors still remains under investigation. OBJECTIVE: The aim of this meta-analysis was to systematically assess the efficacy and safety profiles of next-generation epidermal growth factor receptor-tyrosine kinase inhibitors in patients with advanced non-small cell lung cancer who failed first-generation epidermal growth factor receptor-tyrosine kinase inhibitors...
Source: Technology in Cancer Research and Treatment - January 1, 2020 Category: Cancer & Oncology Authors: Qi YT, Hou Y, Qi LC Tags: Technol Cancer Res Treat Source Type: research

Metabolic Profiling of Human Gastric Cancer Cells Treated With Salazosulfapyridine.
CONCLUSIONS: Our results indicate that in cancer cells having a predominant glycolytic pathway, metabolomic analyses under hypoxic conditions enable the profiling of global metabolism. In addition, inhibiting the supply of nicotinamide adenine dinucleotide phosphate by blocking glycolysis is a potential treatment strategy for cancer, in addition to cystine blockade by salazosulfapyridine. PMID: 32715923 [PubMed - in process] (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - January 1, 2020 Category: Cancer & Oncology Authors: Takizawa K, Muramatsu K, Maruyama K, Urakami K, Sugino T, Kusuhara M, Yamaguchi K, Ono H, Kitagawa Y Tags: Technol Cancer Res Treat Source Type: research

Clinical Significance of Polo-Like Kinase 4 as a Marker for Advanced Tumor Stage and Dismal Prognosis in Patients With Surgical Gastric Cancer.
CONCLUSION: Polo-like kinase 4 possesses the clinical significance as a biomarker for aiding prognostication and facilitating postoperative tumor management in patients with gastric cancer. PMID: 32715931 [PubMed - in process] (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - January 1, 2020 Category: Cancer & Oncology Authors: Cao T, Yi S, Yang X, Wu Q Tags: Technol Cancer Res Treat Source Type: research

Cancer-Testis Gene Expression in Hepatocellular Carcinoma: Identification of Prognostic Markers and Potential Targets for Immunotherapy.
CONCLUSIONS: Our analysis enables better understanding of cancer-testis genes in hepatocellular carcinoma and provides potential targets for hepatocellular carcinoma treatment. Experimental and clinical studies are needed for further validations. PMID: 32715976 [PubMed - in process] (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - January 1, 2020 Category: Cancer & Oncology Authors: Zhang YP, Bao ZW, Wu JB, Chen YH, Chen JR, Xie HY, Zhou L, Wu J, Zheng SS Tags: Technol Cancer Res Treat Source Type: research

PPM1D Knockdown Suppresses Cell Proliferation, Promotes Cell Apoptosis, and Activates p38 MAPK/p53 Signaling Pathway in Acute Myeloid Leukemia.
CONCLUSION: Protein phosphatase, Mg2+/Mn2+ dependent 1D is implicated in acute myeloid leukemia carcinogenesis, which illuminates its potential role as a treatment target for acute myeloid leukemia. PMID: 32691668 [PubMed - in process] (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - January 1, 2020 Category: Cancer & Oncology Authors: Li B, Hu J, He D, Chen Q, Liu S, Zhu X, Yu M Tags: Technol Cancer Res Treat Source Type: research

MicroRNA-499 Suppresses the Growth of Hepatocellular Carcinoma by Downregulating Astrocyte Elevated Gene-1.
Abstract The aim of this study is to investigate the role of microRNA-499 (miR-499) in hepatocellular carcinoma tumor growth and the underlying molecular mechanisms. The expression of miR-499 was significantly decreased in hepatocellular carcinoma tissues compared with that in adjacent normal tissues. Furthermore, miR-499 overexpression in HEPG2 cell was related to the tumor growth in nude mice xenograft models. Likewise, miR-499 mimic or inhibitor decreased or accelerated cell proliferation, respectively. Mechanistically, miR-499 directly targeted the 3'- untranslated region of astrocyte elevated gene-1 and downr...
Source: Technology in Cancer Research and Treatment - January 1, 2020 Category: Cancer & Oncology Authors: Wang J, Li J, Chen L, Fan Z, Cheng J Tags: Technol Cancer Res Treat Source Type: research

Avoidance and Period-Shortening of Neoadjuvant Chemotherapy Against Triple-Negative Breast Cancer in Stages I and II: Importance of Ki-67 Labeling Index and the Recognition of Apocrine-Type Lesions.
Abstract BACKGROUND: Triple-negative breast cancer encompasses heterogeneous subtypes. Neoadjuvant chemotherapy is ineffective against some triple-negative breast cancers, while others show a favorable prognosis despite chemoresistance. METHODS: A total of 51 cases with stages I and II triple-negative breast cancer were analyzed; 34 triple-negative breast cancers treated with neoadjuvant chemotherapy were divided into "good responders" (n = 22), showing therapeutic effect G2b or G3 in surgical specimens, and "poor responders" with therapeutic effect G0, G1a, G1b, and G2a (n = 12). Neoadjuv...
Source: Technology in Cancer Research and Treatment - January 1, 2020 Category: Cancer & Oncology Authors: Kubouchi K, Shimada K, Yokoe T, Tsutsumi Y Tags: Technol Cancer Res Treat Source Type: research

Corrigendum to Clinicopathologic Analysis of Oral Squamous Cell Carcinoma After 125I Interstitial Brachytherapy.
Authors: PMID: 32677870 [PubMed - as supplied by publisher] (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - January 1, 2020 Category: Cancer & Oncology Tags: Technol Cancer Res Treat Source Type: research

New Techniques in Understanding Cancer Biology and Metabolism.
PMID: 32672097 [PubMed - in process] (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - January 1, 2020 Category: Cancer & Oncology Authors: Biswas D, Khan MW Tags: Technol Cancer Res Treat Source Type: research

CFIm25 in Solid Tumors: Current Research Progress.
Abstract Cleavage factor I m25 is a newly discovered solid tumor-related gene, however, its precise role in cancer pathogenesis has not yet been characterized. Alternative polyadenylation is an RNA-processing mechanism that generates distinct 3'-termini on messenger RNAs, producing messenger RNA isoforms. Different factors influence the initiation and development of this process. As a key factor in alternative polyadenylation, cleavage factor I m25 plays an important role in messenger RNA maturation and cell signal transduction. Moreover, by regulating the process of alternative polyadenylation, it can inhibit the...
Source: Technology in Cancer Research and Treatment - January 1, 2020 Category: Cancer & Oncology Authors: Sun X, Li J, Sun X, Liu W, Meng X Tags: Technol Cancer Res Treat Source Type: research

MiR-7 Functions as a Tumor Suppressor by Targeting the Oncogenes TAL1 in T-Cell Acute Lymphoblastic Leukemia.
CONCLUSIONS: These results indicate that microRNA-7 functions as a potent tumor suppressor by inhibiting the oncogene TAL1 and suggest microRNA-7 could function as a prognostic biomarker and possible therapeutic in the clinical management of T-cell acute lymphoblastic leukemia. PMID: 32633635 [PubMed - in process] (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - January 1, 2020 Category: Cancer & Oncology Authors: Sun H, Zhang Z, Luo W, Liu J, Lou Y, Xia S Tags: Technol Cancer Res Treat Source Type: research

Helical IMRT-Based Stereotactic Body Radiation Therapy Using an Abdominal Compression Technique and Modified Fractionation Regimen for Small Hepatocellular Carcinoma.
CONCLUSIONS: When using an abdominal compression technique and modified fractionation regimen (5-10 fractions) based on helical intensity-modified radiation therapy, stereotactic body radiation therapy led to a lower toxicity and comparative rate of local control and overall survival for patients who with small-sized hepatocellular carcinoma. PMID: 32613904 [PubMed - in process] (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - January 1, 2020 Category: Cancer & Oncology Authors: Chen YX, Zhuang Y, Yang P, Fan J, Zhou J, Hu Y, Zhu WC, Sun J, Zeng ZC Tags: Technol Cancer Res Treat Source Type: research

Elevated MYO10 Predicts Poor Prognosis and its Deletion Hampers Proliferation and Migration Potentials of Cells Through Rewiring PI3K/Akt Signaling in Cervical Cancer.
Abstract MYO10, recognized as an important regulator of cytoskeleton remodeling, has been reported to be associated with tumorigenesis. However, its functional implication in cervical cancer and potential mechanism still remain to be undetermined currently. MYO10 level in cervical cancer tissues was analyzed by using data retrieved from The Cancer Genome Atlas and ONCOMINE databases. Messenger RNA and protein expression levels were determined by quantitative real-time polymerase chain reaction and Western blotting. Small-interfering RNA and overexpressing plasmid were used for MYO10 silencing and overexpression, a...
Source: Technology in Cancer Research and Treatment - January 1, 2020 Category: Cancer & Oncology Authors: He JH, Chen JG, Zhang B, Chen J, You KL, Hu JM, Xu JW, Chen L Tags: Technol Cancer Res Treat Source Type: research

Poor Prognosis Biomolecular Factors Are Highly Frequent in Childhood Acute Leukemias From Oaxaca, Mexico.
CONCLUSION: Our findings identify near 50% of patients with acute lymphoblastic leukemia at debut with high-risk translocations and poor prognosis in B-cell acute lymphoblastic leukemia as well as an unexpected increase of acute myeloid leukemia cases in young children, suggesting a molecular shift that support a higher incidence of poor prognosis cases in Oaxaca. PMID: 32608319 [PubMed - in process] (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - January 1, 2020 Category: Cancer & Oncology Authors: Juárez-Avendaño G, Luna-Silva NC, Chargoy-Vivaldo E, Juárez-Martínez LA, Martínez-Rangel MN, Zárate-Ortiz N, Martínez-Valencia E, López-Martínez B, Pelayo R, Balandrán JC Tags: Technol Cancer Res Treat Source Type: research

Delivery of Radiation at the Lowest Dose Rate by a Modern Linear Accelerator is Most Effective in Inhibiting Prostate Cancer Growth.
Abstract PURPOSE: External beam radiotherapy is one of the treatment options for organ-confined prostate cancer. A total dose of 70 to 81 Gray (Gy) is given daily (1.8-2.5 Gy/d), with a dose rate of 3 to 6 Gy/min over 28 to 45 treatments during 8 to 9 weeks. We applied the latest technological development in linear accelerators for enabling a wide range of dose rates (from 0.2-21 Gy/min) to test the effect of different delivery dose rates on prostate tumor growth in an animal xenograft model. MATERIALS AND METHODS: A prostate cancer xenograft model was established in CD1/nude mice by means of PC-3 and CL...
Source: Technology in Cancer Research and Treatment - January 1, 2020 Category: Cancer & Oncology Authors: Tazat K, Reshetnyak O, Shtraus N, Sayag I, Mabjeesh NJ, Amir S Tags: Technol Cancer Res Treat Source Type: research

Efficacy and the Adverse Effects of Oral Versus Intravenous Arsenic for Acute Promyelocytic Leukemia: A Meta-Analysis of Randomized-Controlled Studies.
Abstract Acute promyelocytic leukemia, a subtype of acute myeloid leukemia, is highly curable. In subgroup of patients with non-high-risk acute promyelocytic leukemia, intravenous arsenic trioxide plus all-trans-retinoic acid is considered the preferred regimen for acute promyelocytic leukemia. Recently, there are interests in the use of the oral form of arsenic, named the Realgar-Indigo naturalis formula, but the data on its efficacy and safety are still relatively limited. The current study was conducted with the aims to identify and summarize the results of all available randomized-controlled studies. A systema...
Source: Technology in Cancer Research and Treatment - January 1, 2020 Category: Cancer & Oncology Authors: Sasijareonrat N, Jahn N, Ungprasert P, Owattanapanich W Tags: Technol Cancer Res Treat Source Type: research

DAB2IP Plays Important Clinical Significance and Correlates With Immune Infiltration in Renal Cell Carcinoma.
CONCLUSIONS: These findings suggest that disabled homolog 2-interacting protein functions as a tumor suppressor in the progression of renal cell carcinoma, and the expression of disabled homolog 2-interacting protein is related to the immune infiltrating cells and affects the survival of renal cell carcinoma. Disabled homolog 2-interacting protein can be a novel clinical biomarker for patients with renal cell carcinoma, which also provides new insights for the future treatments of renal cell carcinoma. PMID: 32583730 [PubMed - in process] (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - January 1, 2020 Category: Cancer & Oncology Authors: Cao H, Zhang J, Wang W Tags: Technol Cancer Res Treat Source Type: research

Long Noncoding RNA LINC00634 Functions as an Oncogene in Esophageal Squamous Cell Carcinoma Through the miR-342-3p/Bcl2L1 Axis.
In this study, we show that LINC00634 is upregulated in esophageal cancer. We also show that the knockdown of LINC00634 decreased cell viability and increased cell apoptosis levels in EC9706 and EC1 cells through the miR-342-3p/Bcl2L1 axis. PMID: 32583748 [PubMed - in process] (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - January 1, 2020 Category: Cancer & Oncology Authors: Zhang X, Feng Y, Gao Y, Hu J Tags: Technol Cancer Res Treat Source Type: research

MiR-222-3p Promotes Cell Proliferation and Inhibits Apoptosis by Targeting PUMA (BBC3) in Non-Small Cell Lung Cancer.
In conclusion, microRNA-222-3p plays a significant role in the regulation of Bcl-2-binding component 3 expression and might be a promising target for clinical non-small cell lung cancer therapy. PMID: 32588752 [PubMed - in process] (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - January 1, 2020 Category: Cancer & Oncology Authors: Chen W, Li X Tags: Technol Cancer Res Treat Source Type: research

A Novel Immune-Related Prognostic Signature for Thyroid Carcinoma.
CONCLUSIONS: We constructed a novel 5 immune-associated genes signature for predicting the prognosis of patients with thyroid cancer, which may help clinical workers evaluate individualized therapy and prognosis. PMID: 32588760 [PubMed - in process] (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - January 1, 2020 Category: Cancer & Oncology Authors: Xue Y, Li J, Lu X Tags: Technol Cancer Res Treat Source Type: research

MiR-590 Suppresses Proliferation and Induces Apoptosis in Pancreatic Cancer by Targeting High Mobility Group A2.
CONCLUSION: Our study indicated that microRNA-590 negatively regulates the expression of high mobility group AT-hook 2 in clinical specimens and in vitro. MicroRNA-590 can inhibit cell proliferation and induce cell apoptosis in pancreatic ductal adenocarcinoma cells. This regulatory effect of microRNA-590 may be associated with AKT signaling pathway. Therefore, microRNA-590 has the potential to be used as a biomarker for predicting the progression of pancreatic ductal adenocarcinoma. PMID: 32588766 [PubMed - in process] (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - January 1, 2020 Category: Cancer & Oncology Authors: Wang YD, Mao JD, Wang JF, Xu MQ Tags: Technol Cancer Res Treat Source Type: research

DCK is an Unfavorable Prognostic Biomarker and Correlated With Immune Infiltrates in Liver Cancer.
CONCLUSIONS: All the above findings suggested that increased expression of deoxycytidine kinase was significantly related to unfavorable prognosis in patients with liver cancer. And deoxycytidine kinase is correlated with immune infiltrating levels, including those of B cells, macrophages, neutrophils, and dendritic cells in patients with liver cancer. These findings suggest that deoxycytidine kinase can be used as a prognostic biomarker for determining prognosis and immune infiltration in liver cancer. And deoxycytidine kinase is a potential target for liver cancer therapy, and these preliminary findings require further s...
Source: Technology in Cancer Research and Treatment - January 1, 2020 Category: Cancer & Oncology Authors: Hu SF, Lin X, Xu LP, Chen HG, Guo JF, Jin L Tags: Technol Cancer Res Treat Source Type: research

Combination of Plasma MIF and VCA-IgA Improves the Diagnostic Specificity for Patients With Nasopharyngeal Carcinoma.
CONCLUSION: The combination of macrophage migration inhibitory factor and Epstein-Barr virus viral capsid antigen increases the specificity and positive predictive value of detecting nasopharyngeal carcinoma and improves the diagnostic accuracy of nasopharyngeal carcinoma in high-risk individuals. PMID: 32578505 [PubMed - in process] (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - January 1, 2020 Category: Cancer & Oncology Authors: Xue N, Xing S, Ma W, Sheng J, Huang Z, Xu Q Tags: Technol Cancer Res Treat Source Type: research

Clinical Efficacy of HiPorfin Photodynamic Therapy for Advanced Obstructive Esophageal Cancer.
Abstract OBJECTIVE: To explore the clinical efficacy of HiPorfin photodynamic therapy for advanced esophageal cancer and evaluate its impact on survival. METHODS: Retrospective analysis of 32 patients with advanced obstructive esophageal cancer at our institution from September 2013 to December 2016. HiPorfin was infused as the photosensitizer at a dose of 5 mg/kg, and after 48 hours, 630-nm laser irradiation was subsequently performed through an optical fiber that passed through the biopsy channel of a flexible endoscope. RESULTS: The effectiveness rate was 78.1% (25/32), and the significant efficacy ra...
Source: Technology in Cancer Research and Treatment - January 1, 2020 Category: Cancer & Oncology Authors: Zeng R, Liu C, Li L, Cai X, Chen R, Li Z Tags: Technol Cancer Res Treat Source Type: research

Gamma Radiation-Attenuated Toxoplasma gondii Provokes Apoptosis in Ehrlich Ascites Carcinoma-Bearing Mice Generating Long-Lasting Immunity.
CONCLUSION: Hence, there is an evidence of potency of radiation attenuated Toxoplasma vaccine in immune activation and targeting tumor cell that can be used as a prophylactic or an adjuvant in combination with chemotherapeutic drugs. PMID: 32567499 [PubMed - in process] (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - January 1, 2020 Category: Cancer & Oncology Authors: Hafez EN, Moawed FSM, Abdel-Hamid GR, Elbakary NM Tags: Technol Cancer Res Treat Source Type: research

Can Statin Treatment Reduce the Risk of Hepatocellular Carcinoma? A Systematic Review and Meta-Analysis.
CONCLUSIONS: Findings from this meta-analysis support that statin use can significantly reduce the incidence of hepatocellular carcinoma. PMID: 32552476 [PubMed - in process] (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - January 1, 2020 Category: Cancer & Oncology Authors: Chang Y, Liu Q, Zhou Z, Ding Y, Yang M, Xu W, Chen K, Zhang Q, Wang Z, Li H Tags: Technol Cancer Res Treat Source Type: research

Automatic Planning for Nasopharyngeal Carcinoma Based on Progressive Optimization in RayStation Treatment Planning System.
Abstract OBJECTIVE: To evaluate and quantify the planning performance of automatic planning (AP) with manual planning (MP) for nasopharyngeal carcinoma in the RayStation treatment planning system (TPS). METHODS: A progressive and effective design method for AP of nasopharyngeal carcinoma was realized through automated scripts in this study. A total of 30 patients with nasopharyngeal carcinoma with initial treatment was enrolled. The target coverage, conformity index (CI), homogeneity index (HI), organs at risk sparing, and the efficiency of design and execution were compared between automatic and manual volum...
Source: Technology in Cancer Research and Treatment - January 1, 2020 Category: Cancer & Oncology Authors: Yang Y, Shao K, Zhang J, Chen M, Chen Y, Shan G Tags: Technol Cancer Res Treat Source Type: research

Hsa_Circ_0007841 Enhances Multiple Myeloma Chemotherapy Resistance Through Upregulating ABCG2.
Abstract The current researches have reported that circular RNA is an important regulatory factor in the progression of various human disease. However, the function and mechanism of most circular RNAs remain unknown in cancers including multiple myeloma. Our study has confirmed that hsa_circ_0007841 is up regulated in U266 doxorubicin resistant cells (U266R) and 8226 doxorubicin resistant cells (8226R) compared to U266 parent cells (U266P) and 8226 parent cells (8226P). Silence of hsa_circ_0007841 in U266R and 8226R could reduce the half-maximal inhibitory concentration which indicated reduction in chemoresistance...
Source: Technology in Cancer Research and Treatment - January 1, 2020 Category: Cancer & Oncology Authors: Song Y, Hu N, Song X, Yang J Tags: Technol Cancer Res Treat Source Type: research

MicroRNA-96-5p Facilitates the Viability, Migration, and Invasion and Suppresses the Apoptosis of Cervical Cancer Cells byNegatively Modulating SFRP4.
CONCLUSIONS: MicroRNA-96-5p facilitated the viability, migration, and invasion and inhibited the apoptosis of cervical cancer cells via negatively regulating secreted frizzled-related protein 4. PMID: 32527205 [PubMed - in process] (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - January 1, 2020 Category: Cancer & Oncology Authors: Zhang H, Chen R, Shao J Tags: Technol Cancer Res Treat Source Type: research

Knockdown of Ubiquitin-Specific Protease 53 Enhances the Radiosensitivity of Human Cervical Squamous Cell Carcinoma by Regulating DNA Damage-Binding Protein 2.
CONCLUSION: Ubiquitin-specific protein 53-induced cell cycle arrest and affected the radiotherapy sensitivity of tumors through damage-specific DNA binding protein. PMID: 32508265 [PubMed - in process] (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - January 1, 2020 Category: Cancer & Oncology Authors: Zhou Q, Yao X, Wu C, Chen S, Fan D Tags: Technol Cancer Res Treat Source Type: research

MiRNA-12129 Suppresses Cell Proliferation and Block Cell Cycle Progression by Targeting SIRT1 in GASTRIC Cancer.
Abstract Gastric cancer is the most commonly occurring cancer with a rapidly increasing incidence rate worldwide. The underlying molecular mechanisms of gastric cancer require further investigation. MicroRNAs exhibit tissue sensitivity as tumor biomarkers that play a role by promoting tumor growth as oncogenes or tumor suppressor genes. We evaluated the effects of microRNA-12129 on gastric cancer and identified the underlying mechanisms of microRNA-12129. Quantitative real-time polymerase chain reaction was conducted to determine the expression levels of microRNA-12129 and sirtuin 1 in vivo and in vitro, and Weste...
Source: Technology in Cancer Research and Treatment - January 1, 2020 Category: Cancer & Oncology Authors: Zhang W, Liao K, Liu D Tags: Technol Cancer Res Treat Source Type: research

Combinational Treatment of Doxorubicin With Neoadjuvant Docetaxel for Different Subtypes of Patients With Breast Cancer.
CONCLUSION: The molecular subtypes of breast cancer can predict responses to the combinational treatment of doxorubicin with docetaxel, and ERBB2+ and basal-like subtypes have better response rate and complete response rate. There is correlation of estrogen receptor and KI-67 level changes with response rate as well, where KI-67 high patients are more sensitive to the treatment. PMID: 32508292 [PubMed - in process] (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - January 1, 2020 Category: Cancer & Oncology Authors: Wang LC, Wang LS, Li AX, Shi ZZ, Li YQ, Huang W, Chen SM, Han F, Zhu DQ Tags: Technol Cancer Res Treat Source Type: research

Knockdown of NCOA2 Inhibits the Growth and Progression of Gastric Cancer by Affecting the Wnt Signaling Pathway-Related Protein Expression.
Abstract OBJECTIVE: The aim of the study is to determine the role of nuclear receptor coactivator 2 in cell proliferation and invasion ability of gastric cancer cells and to explore its possible mechanisms. METHODS: Immunohistochemical staining was used to determine NCOA2 gene expression in gastric cancer. Western blotting was used to detect Wnt signal pathways-related protein expression. Colony formation assays, Cell Counting Kit-8 assays, and transwell assays were used to determine cell proliferation, metastasis, and invasion ability of gastric cancer cells. A flow cytometric apoptosis tests determine gastr...
Source: Technology in Cancer Research and Treatment - January 1, 2020 Category: Cancer & Oncology Authors: Lin Z, Yang F, Lu D, Sun W, Zhu G, Lan B Tags: Technol Cancer Res Treat Source Type: research

Patterns of Failure in Patients With Head and Neck Squamous Cell Carcinomas of Unknown Primary Treated With Chemoradiotherapy.
CONCLUSIONS: All local nodal recurrences occurred at sites that received high radiotherapy doses and doses received by sites of eventual failure did not vary significantly from sites that remain in control. PMID: 32484037 [PubMed - in process] (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - January 1, 2020 Category: Cancer & Oncology Authors: Dhouib F, Bertaut A, Maingon P, Siala W, Daoud J, Aubignac L, Lestrade L, Crehange G, Vulquin N Tags: Technol Cancer Res Treat Source Type: research

Integrated Profiling Revealed Potential Regulatory Networks Among Long Noncoding RNAs and mRNAs in Mucosal Gastric Cancer.
This study revealed the dysregulated long noncoding RNA profiles of mucosal gastric cancer. The results shed light on the biological function of long noncoding RNAs in gastric cancer pathogenesis. This provides useful information for exploring potential early screening biomarkers in gastric cancer. PMID: 32468960 [PubMed - in process] (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - January 1, 2020 Category: Cancer & Oncology Authors: Sun KK, Shen XJ, Yang D, Jiao Y, Wu XY Tags: Technol Cancer Res Treat Source Type: research

Circular RNA hsa_circ_0000376 Participates in Tumorigenesis of Breast Cancer by Targeting miR-1285-3p.
This study was designed to identify novel circular RNAs and the related regulatory axis to provide research targets for the diagnosis and treatment of breast cancer. The circular RNA expression microarray "GSE101123" related to breast cancer was downloaded from the Gene Expression Omnibus database. The differentially expressed circular RNAs between tumor and normal samples were screened using Limma package. The targeted microRNAs of the differentially expressed circular RNAs and the targeted messenger RNAs of the microRNAs were predicted using miRanda and miRWalk, respectively, and a circular RNAs-microRNAs-messe...
Source: Technology in Cancer Research and Treatment - January 1, 2020 Category: Cancer & Oncology Authors: Peng Z, Xu B, Jin F Tags: Technol Cancer Res Treat Source Type: research

MiR-133 Targets YES1 and Inhibits the Growth of Triple-Negative Breast Cancer Cells.
In this study, we identified the significant reduction of miR-133 in triple-negative breast cancer tissues and cell lines. Ectopic overexpression of miR-133 suppressed the proliferation, colony formation, and upregulated the apoptosis of triple-negative breast cancer cells. Mechanism study revealed that the YES Proto-Oncogene 1 was a target of miR-133. miR-133 bound the 3'-untranslated region of YES Proto-Oncogene 1 and decreased the level of YES Proto-Oncogene 1 in triple-negative breast cancer cells. Consistent with miR-133 downregulation, YES1 was significantly increased in triple-negative breast cancer, which was inver...
Source: Technology in Cancer Research and Treatment - January 1, 2020 Category: Cancer & Oncology Authors: Zhang G, Wang J, Zheng R, Song B, Huang L, Liu Y, Hao Y, Bai X Tags: Technol Cancer Res Treat Source Type: research

PYGB Promoted Tumor Progression by Regulating Wnt/ β-Catenin Pathway in Gastric Cancer.
PYGB Promoted Tumor Progression by Regulating Wnt/β-Catenin Pathway in Gastric Cancer. Technol Cancer Res Treat. 2020 Jan-Dec;19:1533033820926592 Authors: Xia B, Zhang K, Liu C Abstract Gastric cancer is one of the most common gastrointestinal malignancy with high mortality in East Asia. Investigation of pathogenic mechanisms of gastric cancer is crucial to develop novel therapeutic strategies and identify new therapeutic candidates. Brain-type glycogen phosphorylase is a glycogen phosphorylase involved in glycogen metabolism, which participates in multiple physiological and pathological processe...
Source: Technology in Cancer Research and Treatment - January 1, 2020 Category: Cancer & Oncology Authors: Xia B, Zhang K, Liu C Tags: Technol Cancer Res Treat Source Type: research

Semaphorin 3F Serves as a Tumor Suppressor in Esophageal Squamous Cell Carcinoma and is Associated With Lymph Node Metastasis in Disease Progression.
CONCLUSION: All data indicate that semaphorin 3F serves as a potential prognostic biomarker and tumor suppressor of esophageal squamous cell carcinoma and may be involved in the lymph node metastasis development through regulating neuropilin 2. PMID: 32441221 [PubMed - in process] (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - January 1, 2020 Category: Cancer & Oncology Authors: Xie Z, Li T, Huang B, Liu S, Zhang L, Zhang Q Tags: Technol Cancer Res Treat Source Type: research

Sodium Tanshinone IIA Sulfonate Attenuates Tumor Oxidative Stress and Promotes Apoptosis in an Intermittent Hypoxia Mouse Model.
CONCLUSION: Intermittent hypoxia treatment resulted in high oxidative stress and low apoptosis in Lewis lung carcinoma-implanted mice, which could be attenuated by sodium tanshinone IIA sulfonate administration possibly through a mechanism mediated by the nuclear factor erythroid 2-related factor 2/nuclear factor kappa B signaling pathway. PMID: 32431212 [PubMed - in process] (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - January 1, 2020 Category: Cancer & Oncology Authors: Zhang XB, Chen XY, Sun P, Su XM, Zeng HQ, Zeng YM, Wang M, Luo X Tags: Technol Cancer Res Treat Source Type: research

Long Noncoding RNA WT1-AS Inhibit Cell Malignancy via miR-494-3p in Glioma.
In this study, we found that, levels of WT1-AS were significantly reduced in glioma tissues and cell lines. The miR-494-3p levels were negatively correlated with WT1-AS levels. The cellular proliferation and invasiveness decreased in WT1-AS transfected cell lines. Further the half maximal inhibitory concentration (IC50) of chemotherapeutic agent temozolomide was significantly reduced in the presence of WT1-AS. The cotransfection of WT1-AS and miR-494-3p reduced activation of phospho-AKT (p-AKT). Expression of miR-494-3p is modulated by binding to long noncoding RNA WT1-AS. Deregulation of WT1-AS leads to aberrant expressio...
Source: Technology in Cancer Research and Treatment - January 1, 2020 Category: Cancer & Oncology Authors: Qiu G, Tong W, Jiang C, Xie Q, Zou J, Luo C, Zhao J, Zhang L, Zhao J Tags: Technol Cancer Res Treat Source Type: research

miR-3196 acts as a Tumor Suppressor and Predicts Survival Outcomes in Patients With Gastric Cancer.
CONCLUSIONS: These results suggested that microRNA-3196 might not only a tumor suppressor in gastric cancer cells by modulating OTX1 but also might be an independent prognostic biomarker and therapeutic target of gastric cancer. PMID: 32419651 [PubMed - in process] (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - January 1, 2020 Category: Cancer & Oncology Authors: Chen G, Wan J, Wang Z, Li L, Jia H, Xing S, Chen S, Fan X, Li R Tags: Technol Cancer Res Treat Source Type: research