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The Role of microRNAs in Hepatocellular Cancer: A Narrative Review Focused on Tumor Microenvironment and Drug Resistance
Technol Cancer Res Treat. 2024 Jan-Dec;23:15330338241239188. doi: 10.1177/15330338241239188.ABSTRACTGlobally, hepatic cancer ranks fourth in terms of cancer-related mortality and is the sixth most frequent kind of cancer. Around 80% of liver cancers are hepatocellular carcinomas (HCC), which are the leading cause of cancer death. It is well known that HCC may develop resistance to the available chemotherapy treatments very fast. One of the biggest obstacles in providing cancer patients with appropriate care is drug resistance. According to reports, more than 90% of cancer-specific fatalities are caused by treatment resista...
Source: Technology in Cancer Research and Treatment - April 18, 2024 Category: Cancer & Oncology Authors: Ali Tavakoli Pirzaman Ali Alishah Bahareh Babajani Pouyan Ebrahimi Seyyed Ali Sheikhi Farhad Moosaei Amirhossein Salarfar Shahrbanoo Doostmohamadian Sohrab Kazemi Source Type: research

Clinical and Radiological Factors for Predicting Clinically Significant Prostate Cancer in Biopsy-Naive Patients With PI-RADS 3 Lesions
CONCLUSION: The combination of age, prostate-specific antigen density, lesion volume, apparent diffusion coefficient, and digital rectal examination presented a higher diagnostic value for clinically significant prostate cancer than any single parameter in patients with Prostate Imaging Reporting and Data System 3 lesions. Systematic biopsy proved crucial for biopsy-naive patients with Prostate Imaging Reporting and Data System 3 lesions and should not be omitted.PMID:38629205 | PMC:PMC11025422 | DOI:10.1177/15330338241246636 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - April 17, 2024 Category: Cancer & Oncology Authors: Zhiyu Zhang Can Hu Yuxin Lin Ouyang Song Dongkui Gong Xuefeng Zhang Nan Wang Source Type: research

Clinical and Radiological Factors for Predicting Clinically Significant Prostate Cancer in Biopsy-Naive Patients With PI-RADS 3 Lesions
CONCLUSION: The combination of age, prostate-specific antigen density, lesion volume, apparent diffusion coefficient, and digital rectal examination presented a higher diagnostic value for clinically significant prostate cancer than any single parameter in patients with Prostate Imaging Reporting and Data System 3 lesions. Systematic biopsy proved crucial for biopsy-naive patients with Prostate Imaging Reporting and Data System 3 lesions and should not be omitted.PMID:38629205 | DOI:10.1177/15330338241246636 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - April 17, 2024 Category: Cancer & Oncology Authors: Zhiyu Zhang Can Hu Yuxin Lin Ouyang Song Dongkui Gong Xuefeng Zhang Nan Wang Source Type: research

Corrigendum
Technol Cancer Res Treat. 2024 Jan-Dec;23:15330338241241784. doi: 10.1177/15330338241241784.NO ABSTRACTPMID:38623700 | DOI:10.1177/15330338241241784 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - April 16, 2024 Category: Cancer & Oncology Source Type: research

Clinical Value of Human Endogenous Retrovirus-H Long Terminal Repeat Associating 2 (HHLA2) in Small Cell Lung Cancer
Conclusion: The new immune molecule HHLA2 may be an ideal clinical biomarker for predicting SCLC progression and could serve as a new immunotherapy target in SCLC.PMID:38613340 | PMC:PMC11015749 | DOI:10.1177/15330338241240683 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - April 13, 2024 Category: Cancer & Oncology Authors: Xiuqin Zhang Yan Qin Xu Chen Mengrui Xiong Song Shu Source Type: research

Predictive Value of NLR and PLR in Driver-Gene-Negative Advanced Non-Small Cell Lung Cancer Treated with PD-1/PD-L1 Inhibitors: A Single Institutional Cohort Study
CONCLUSION: Low baseline NLR and PLR levels are significantly associated with better response in advanced NSCLC patients treated with PD-1/PD-L1 inhibitors, which may be indicators to predict the efficacy of immunotherapy in advanced NSCLC with driver-gene-negative.PMID:38613344 | PMC:PMC11015757 | DOI:10.1177/15330338241246651 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - April 13, 2024 Category: Cancer & Oncology Authors: Qi Yuan Chunhua Xu Wei Wang Qian Zhang Source Type: research

Fibroblast Growth Factor 23 is a Potential Prognostic Biomarker in Uterine Sarcoma
CONCLUSION: FGF23 was highly expressed in US and was promising as a novel potential biomarker for the diagnosis and prognosis of US.PMID:38613349 | PMC:PMC11015760 | DOI:10.1177/15330338241245924 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - April 13, 2024 Category: Cancer & Oncology Authors: Ling Yang Ying Cai Yunjia Wang Yue Huang Chi Zhang Hu Ma Jian-Guo Zhou Source Type: research

Identification of Novel Cuproptosis-Related Genes Mediating the Prognosis and Immune Microenvironment in Cholangiocarcinoma
CONCLUSIONS: Collectively, we established and verified an effective prognostic model that could separate cholangiocarcinoma patients into 2 heterogeneous cuproptosis subtypes based on the molecular or protein characteristics of 10 cuproptosis-related genes. These findings may provide potential benefits for unveiling molecular characteristics and defining subgroups could improve the early diagnosis and individualized treatment of cholangiocarcinoma patients.PMID:38613350 | PMC:PMC11015765 | DOI:10.1177/15330338241239139 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - April 13, 2024 Category: Cancer & Oncology Authors: Qiang Liu Jianpeng Zhu Zhicheng Huang Xiaofeng Zhang Jianfeng Yang Source Type: research

Clinical Value of Human Endogenous Retrovirus-H Long Terminal Repeat Associating 2 (HHLA2) in Small Cell Lung Cancer
Conclusion: The new immune molecule HHLA2 may be an ideal clinical biomarker for predicting SCLC progression and could serve as a new immunotherapy target in SCLC.PMID:38613340 | DOI:10.1177/15330338241240683 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - April 13, 2024 Category: Cancer & Oncology Authors: Xiuqin Zhang Yan Qin Xu Chen Mengrui Xiong Song Shu Source Type: research

Predictive Value of NLR and PLR in Driver-Gene-Negative Advanced Non-Small Cell Lung Cancer Treated with PD-1/PD-L1 Inhibitors: A Single Institutional Cohort Study
CONCLUSION: Low baseline NLR and PLR levels are significantly associated with better response in advanced NSCLC patients treated with PD-1/PD-L1 inhibitors, which may be indicators to predict the efficacy of immunotherapy in advanced NSCLC with driver-gene-negative.PMID:38613344 | DOI:10.1177/15330338241246651 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - April 13, 2024 Category: Cancer & Oncology Authors: Qi Yuan Chunhua Xu Wei Wang Qian Zhang Source Type: research