Not All Kirsten Rat Sarcoma Viral Oncogene Homolog Mutations Predict Poor Survival in Patients With Unresectable Colorectal Liver Metastasis
Conclusion: KRAS codon 12 mutations were predictive for a poor prognosis in patients with unresectable CRLM. G12D and G12V mutations were associated with worse OS, whereas G12C mutation seemed to be associated with decreased PFS.PMID:34669528 | PMC:PMC8532248 | DOI:10.1177/15330338211039131 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - October 20, 2021 Category: Cancer & Oncology Authors: Zhizun Lin Yi Liu Shaoxin Cai Changshun Yang Liyuan Zhou Weihua Li Source Type: research

Not All Kirsten Rat Sarcoma Viral Oncogene Homolog Mutations Predict Poor Survival in Patients With Unresectable Colorectal Liver Metastasis
Conclusion: KRAS codon 12 mutations were predictive for a poor prognosis in patients with unresectable CRLM. G12D and G12V mutations were associated with worse OS, whereas G12C mutation seemed to be associated with decreased PFS.PMID:34669528 | PMC:PMC8532248 | DOI:10.1177/15330338211039131 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - October 20, 2021 Category: Cancer & Oncology Authors: Zhizun Lin Yi Liu Shaoxin Cai Changshun Yang Liyuan Zhou Weihua Li Source Type: research

Not All Kirsten Rat Sarcoma Viral Oncogene Homolog Mutations Predict Poor Survival in Patients With Unresectable Colorectal Liver Metastasis
Conclusion: KRAS codon 12 mutations were predictive for a poor prognosis in patients with unresectable CRLM. G12D and G12V mutations were associated with worse OS, whereas G12C mutation seemed to be associated with decreased PFS.PMID:34669528 | DOI:10.1177/15330338211039131 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - October 20, 2021 Category: Cancer & Oncology Authors: Zhizun Lin Yi Liu Shaoxin Cai Changshun Yang Liyuan Zhou Weihua Li Source Type: research

Not All Kirsten Rat Sarcoma Viral Oncogene Homolog Mutations Predict Poor Survival in Patients With Unresectable Colorectal Liver Metastasis
Conclusion: KRAS codon 12 mutations were predictive for a poor prognosis in patients with unresectable CRLM. G12D and G12V mutations were associated with worse OS, whereas G12C mutation seemed to be associated with decreased PFS.PMID:34669528 | DOI:10.1177/15330338211039131 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - October 20, 2021 Category: Cancer & Oncology Authors: Zhizun Lin Yi Liu Shaoxin Cai Changshun Yang Liyuan Zhou Weihua Li Source Type: research

Influence of Autophagy Inhibition on Lung Adenocarcinoma Cell Migration and Invasion Ability, and Efficacy of Gefitinib
Technol Cancer Res Treat. 2021 Jan-Dec;20:15330338211049000. doi: 10.1177/15330338211049000.ABSTRACTAn increasing number of studies have emphasized the role of autophagy in cancer cell metastasis and treatment of malignant tumors. Autophagy inhibitors have been widely used in combination therapies to treat advanced malignancies. Several lung adenocarcinoma cells harbor epidermal growth factor receptor (EGFR) gene mutations, and EGFR tyrosine kinase inhibitors (TKIs) are routinely used in the treatment of lung adenocarcinoma. However, a number of lung adenocarcinoma tumors do not respond or develop resistance to EGFR TKIs. ...
Source: Technology in Cancer Research and Treatment - October 18, 2021 Category: Cancer & Oncology Authors: Ying Liu Yun Du Source Type: research

Nanoparticle Albumin Bound Paclitaxel in the Third-Line Treatment of Recurrent Small Cell Lung Cancer in Real-World Practice: A Single Center Experience
Conclusions: As a single-agent third-line treatment for patients with relapsed SCLC, Nab-P was effective and safe.PMID:34657492 | DOI:10.1177/15330338211050775 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - October 18, 2021 Category: Cancer & Oncology Authors: Yuchao Wang Li Li Chunhua Xu Source Type: research

Evaluation of DIBH and VMAT in Hypofractionated Radiotherapy for Left-Sided Breast Cancers After Breast-Conserving Surgery: A Planning Study
Technol Cancer Res Treat. 2021 Jan-Dec;20:15330338211048706. doi: 10.1177/15330338211048706.ABSTRACTBackground: Dosimetric parameters of the planning target volume (PTV) and organs at risk (OARs) were compared among 3 different radiotherapy (RT) modalities in left breast cancer patients after breast-conserving surgery (BCS). Methods: Eleven patients with left breast cancer after BCS were enrolled and underwent CT simulation in the free breathing (FB) and deep inspiration breath-hold (DIBH) position. Three-dimensional conformal RT (3DCRT) and volumetric modulated arc therapy (VMAT) plans were generated for each patient in t...
Source: Technology in Cancer Research and Treatment - October 18, 2021 Category: Cancer & Oncology Authors: Liuwei Tang Yojiro Ishikawa Kengo Ito Takaya Yamamoto Rei Umezawa Keiichi Jingu Source Type: research

Challenges in Advanced Lung Cancer Diagnosis During the COVID-19 Pandemic
Technol Cancer Res Treat. 2021 Jan-Dec;20:15330338211050764. doi: 10.1177/15330338211050764.ABSTRACTA pandemic of coronavirus diseases 2019 (COVID-19) outbreak is a major public health emergency that has spread in the fastest speed, and caused the most extensive infection world widely. Transbronchial biopsy (TBB) and computed tomography guided percutaneous needle biopsy (CTPNB) is the most common and significant method for the diagnosis of lung cancer. During the COVID-19 pandemic, the indications of TBB and CTPNB must be managed strictly. Therefore, it is extremely indispensable to perform meticulous and individualized ma...
Source: Technology in Cancer Research and Treatment - October 18, 2021 Category: Cancer & Oncology Authors: Chunhua Xu Li Li Wei Wang Source Type: research

Additional Radiotherapy With or Without Chemotherapy Following Endoscopic Resection for Stage I Esophageal Carcinoma: A Pilot Study
Conclusions: For patients with stage I EC, additional radiotherapy following ER is safe and effective, with the swallowing function well-preserved. Nevertheless, prospective studies are needed to verify these results.PMID:34657505 | DOI:10.1177/15330338211048051 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - October 18, 2021 Category: Cancer & Oncology Authors: Xu Yang Yu Men Jianyang Wang Jingjing Kang Xin Sun Maoyuan Zhao Shuang Sun Meng Yuan Yongxing Bao Zeliang Ma Guiqi Wang Zhouguang Hui Source Type: research

Identification of Immune Subtypes for Predicting the Prognosis of Patients in Head and Neck Squamous Cell Carcinoma
Technol Cancer Res Treat. 2021 Jan-Dec;20:15330338211045823. doi: 10.1177/15330338211045823.ABSTRACTHead and neck squamous cell carcinoma (HNSCC) is a common malignancy with poor prognosis and immune response, which plays an important role in tumor progression. Recently, immunotherapies have revolutionized the therapeutic means of malignancies including HNSCC. However, the relationship between immunophenotypes of HNSCC and its clinical response to immune-checkpoint inhibitors remains unclear. We aim to identify molecular subtyping related to distinct immunophenotypes in HNSCC. Consensus clustering algorithm was conducted f...
Source: Technology in Cancer Research and Treatment - October 18, 2021 Category: Cancer & Oncology Authors: Jing Sun Guiqing Fang Zhibin Zuo Xijiao Yu Lande Xue Chong Li Shu Li Source Type: research

Hepatic Artery Infusion Pump Combined With Systemic Chemotherapy for Patients With Liver Metastases From Breast Carcinoma
This study aimed to evaluate the efficacy and safety of hepatic arterial infusion (HAI) combined with systemic chemotherapy in patients with breast carcinoma liver metastases (BCLM). Methods: From January 2012 to December 2019, HAI catheter systems were implanted under the guide of digital subtract angiography (DSA) in 19 patients with BCLM. All patients received systemic chemotherapy and HAI gemcitabine plus floxuridine (FUDR). Methods: The overall response rate (ORR) of intrahepatic lesions was 73.7%, including 2 patients (10.5%) with complete remission (CR) and 12 patients (63.2%) with partial remission (PR). Additional...
Source: Technology in Cancer Research and Treatment - October 18, 2021 Category: Cancer & Oncology Authors: Hong-Bing Shi Wei-Guang Qiang Wei-Liang Zhu Ye Yuan Jun-Jun Wang Jie-Min Zhao Wen-Wei Hu Source Type: research

Concurrent Comparison of the Prognostic Values of Tumor Budding, Tumor Stroma Ratio, Tumor Infiltrating Pattern and Lymphocyte-to-Monocyte Ratio in Colorectal Cancer Patients
Technol Cancer Res Treat. 2021 Jan-Dec;20:15330338211045826. doi: 10.1177/15330338211045826.ABSTRACTObjectives: Tumor budding (TB), tumor stroma ratio (TSR), tumor infiltrating pattern (TIP), and preoperative lymphocyte-to-monocyte ratio (LMR) were previously reported to be useful prognostic factors in colorectal cancer (CRC); however, the correlation among these markers and their individual prognostic potency have not been extensively studied. Methods: A cohort of 147 stage I-IV CRC patients was obtained retrospectively, and the patients were divided into subgroups based on low or high TB/TSR/LMR, TIPa (expansile + interm...
Source: Technology in Cancer Research and Treatment - October 18, 2021 Category: Cancer & Oncology Authors: Yingcheng Zhang You Liu Xiaomei Qiu Bing Yan Source Type: research

Influence of Autophagy Inhibition on Lung Adenocarcinoma Cell Migration and Invasion Ability, and Efficacy of Gefitinib
Technol Cancer Res Treat. 2021 Jan-Dec;20:15330338211049000. doi: 10.1177/15330338211049000.ABSTRACTAn increasing number of studies have emphasized the role of autophagy in cancer cell metastasis and treatment of malignant tumors. Autophagy inhibitors have been widely used in combination therapies to treat advanced malignancies. Several lung adenocarcinoma cells harbor epidermal growth factor receptor (EGFR) gene mutations, and EGFR tyrosine kinase inhibitors (TKIs) are routinely used in the treatment of lung adenocarcinoma. However, a number of lung adenocarcinoma tumors do not respond or develop resistance to EGFR TKIs. ...
Source: Technology in Cancer Research and Treatment - October 18, 2021 Category: Cancer & Oncology Authors: Ying Liu Yun Du Source Type: research

Nanoparticle Albumin Bound Paclitaxel in the Third-Line Treatment of Recurrent Small Cell Lung Cancer in Real-World Practice: A Single Center Experience
Conclusions: As a single-agent third-line treatment for patients with relapsed SCLC, Nab-P was effective and safe.PMID:34657492 | DOI:10.1177/15330338211050775 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - October 18, 2021 Category: Cancer & Oncology Authors: Yuchao Wang Li Li Chunhua Xu Source Type: research

Evaluation of DIBH and VMAT in Hypofractionated Radiotherapy for Left-Sided Breast Cancers After Breast-Conserving Surgery: A Planning Study
Technol Cancer Res Treat. 2021 Jan-Dec;20:15330338211048706. doi: 10.1177/15330338211048706.ABSTRACTBackground: Dosimetric parameters of the planning target volume (PTV) and organs at risk (OARs) were compared among 3 different radiotherapy (RT) modalities in left breast cancer patients after breast-conserving surgery (BCS). Methods: Eleven patients with left breast cancer after BCS were enrolled and underwent CT simulation in the free breathing (FB) and deep inspiration breath-hold (DIBH) position. Three-dimensional conformal RT (3DCRT) and volumetric modulated arc therapy (VMAT) plans were generated for each patient in t...
Source: Technology in Cancer Research and Treatment - October 18, 2021 Category: Cancer & Oncology Authors: Liuwei Tang Yojiro Ishikawa Kengo Ito Takaya Yamamoto Rei Umezawa Keiichi Jingu Source Type: research

Challenges in Advanced Lung Cancer Diagnosis During the COVID-19 Pandemic
Technol Cancer Res Treat. 2021 Jan-Dec;20:15330338211050764. doi: 10.1177/15330338211050764.ABSTRACTA pandemic of coronavirus diseases 2019 (COVID-19) outbreak is a major public health emergency that has spread in the fastest speed, and caused the most extensive infection world widely. Transbronchial biopsy (TBB) and computed tomography guided percutaneous needle biopsy (CTPNB) is the most common and significant method for the diagnosis of lung cancer. During the COVID-19 pandemic, the indications of TBB and CTPNB must be managed strictly. Therefore, it is extremely indispensable to perform meticulous and individualized ma...
Source: Technology in Cancer Research and Treatment - October 18, 2021 Category: Cancer & Oncology Authors: Chunhua Xu Li Li Wei Wang Source Type: research

Additional Radiotherapy With or Without Chemotherapy Following Endoscopic Resection for Stage I Esophageal Carcinoma: A Pilot Study
Conclusions: For patients with stage I EC, additional radiotherapy following ER is safe and effective, with the swallowing function well-preserved. Nevertheless, prospective studies are needed to verify these results.PMID:34657505 | DOI:10.1177/15330338211048051 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - October 18, 2021 Category: Cancer & Oncology Authors: Xu Yang Yu Men Jianyang Wang Jingjing Kang Xin Sun Maoyuan Zhao Shuang Sun Meng Yuan Yongxing Bao Zeliang Ma Guiqi Wang Zhouguang Hui Source Type: research

Identification of Immune Subtypes for Predicting the Prognosis of Patients in Head and Neck Squamous Cell Carcinoma
Technol Cancer Res Treat. 2021 Jan-Dec;20:15330338211045823. doi: 10.1177/15330338211045823.ABSTRACTHead and neck squamous cell carcinoma (HNSCC) is a common malignancy with poor prognosis and immune response, which plays an important role in tumor progression. Recently, immunotherapies have revolutionized the therapeutic means of malignancies including HNSCC. However, the relationship between immunophenotypes of HNSCC and its clinical response to immune-checkpoint inhibitors remains unclear. We aim to identify molecular subtyping related to distinct immunophenotypes in HNSCC. Consensus clustering algorithm was conducted f...
Source: Technology in Cancer Research and Treatment - October 18, 2021 Category: Cancer & Oncology Authors: Jing Sun Guiqing Fang Zhibin Zuo Xijiao Yu Lande Xue Chong Li Shu Li Source Type: research

Hepatic Artery Infusion Pump Combined With Systemic Chemotherapy for Patients With Liver Metastases From Breast Carcinoma
This study aimed to evaluate the efficacy and safety of hepatic arterial infusion (HAI) combined with systemic chemotherapy in patients with breast carcinoma liver metastases (BCLM). Methods: From January 2012 to December 2019, HAI catheter systems were implanted under the guide of digital subtract angiography (DSA) in 19 patients with BCLM. All patients received systemic chemotherapy and HAI gemcitabine plus floxuridine (FUDR). Methods: The overall response rate (ORR) of intrahepatic lesions was 73.7%, including 2 patients (10.5%) with complete remission (CR) and 12 patients (63.2%) with partial remission (PR). Additional...
Source: Technology in Cancer Research and Treatment - October 18, 2021 Category: Cancer & Oncology Authors: Hong-Bing Shi Wei-Guang Qiang Wei-Liang Zhu Ye Yuan Jun-Jun Wang Jie-Min Zhao Wen-Wei Hu Source Type: research

Concurrent Comparison of the Prognostic Values of Tumor Budding, Tumor Stroma Ratio, Tumor Infiltrating Pattern and Lymphocyte-to-Monocyte Ratio in Colorectal Cancer Patients
Technol Cancer Res Treat. 2021 Jan-Dec;20:15330338211045826. doi: 10.1177/15330338211045826.ABSTRACTObjectives: Tumor budding (TB), tumor stroma ratio (TSR), tumor infiltrating pattern (TIP), and preoperative lymphocyte-to-monocyte ratio (LMR) were previously reported to be useful prognostic factors in colorectal cancer (CRC); however, the correlation among these markers and their individual prognostic potency have not been extensively studied. Methods: A cohort of 147 stage I-IV CRC patients was obtained retrospectively, and the patients were divided into subgroups based on low or high TB/TSR/LMR, TIPa (expansile + interm...
Source: Technology in Cancer Research and Treatment - October 18, 2021 Category: Cancer & Oncology Authors: Yingcheng Zhang You Liu Xiaomei Qiu Bing Yan Source Type: research

Influence of Autophagy Inhibition on Lung Adenocarcinoma Cell Migration and Invasion Ability, and Efficacy of Gefitinib
Technol Cancer Res Treat. 2021 Jan-Dec;20:15330338211049000. doi: 10.1177/15330338211049000.ABSTRACTAn increasing number of studies have emphasized the role of autophagy in cancer cell metastasis and treatment of malignant tumors. Autophagy inhibitors have been widely used in combination therapies to treat advanced malignancies. Several lung adenocarcinoma cells harbor epidermal growth factor receptor (EGFR) gene mutations, and EGFR tyrosine kinase inhibitors (TKIs) are routinely used in the treatment of lung adenocarcinoma. However, a number of lung adenocarcinoma tumors do not respond or develop resistance to EGFR TKIs. ...
Source: Technology in Cancer Research and Treatment - October 18, 2021 Category: Cancer & Oncology Authors: Ying Liu Yun Du Source Type: research

Nanoparticle Albumin Bound Paclitaxel in the Third-Line Treatment of Recurrent Small Cell Lung Cancer in Real-World Practice: A Single Center Experience
Conclusions: As a single-agent third-line treatment for patients with relapsed SCLC, Nab-P was effective and safe.PMID:34657492 | DOI:10.1177/15330338211050775 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - October 18, 2021 Category: Cancer & Oncology Authors: Yuchao Wang Li Li Chunhua Xu Source Type: research

Evaluation of DIBH and VMAT in Hypofractionated Radiotherapy for Left-Sided Breast Cancers After Breast-Conserving Surgery: A Planning Study
Technol Cancer Res Treat. 2021 Jan-Dec;20:15330338211048706. doi: 10.1177/15330338211048706.ABSTRACTBackground: Dosimetric parameters of the planning target volume (PTV) and organs at risk (OARs) were compared among 3 different radiotherapy (RT) modalities in left breast cancer patients after breast-conserving surgery (BCS). Methods: Eleven patients with left breast cancer after BCS were enrolled and underwent CT simulation in the free breathing (FB) and deep inspiration breath-hold (DIBH) position. Three-dimensional conformal RT (3DCRT) and volumetric modulated arc therapy (VMAT) plans were generated for each patient in t...
Source: Technology in Cancer Research and Treatment - October 18, 2021 Category: Cancer & Oncology Authors: Liuwei Tang Yojiro Ishikawa Kengo Ito Takaya Yamamoto Rei Umezawa Keiichi Jingu Source Type: research

Challenges in Advanced Lung Cancer Diagnosis During the COVID-19 Pandemic
Technol Cancer Res Treat. 2021 Jan-Dec;20:15330338211050764. doi: 10.1177/15330338211050764.ABSTRACTA pandemic of coronavirus diseases 2019 (COVID-19) outbreak is a major public health emergency that has spread in the fastest speed, and caused the most extensive infection world widely. Transbronchial biopsy (TBB) and computed tomography guided percutaneous needle biopsy (CTPNB) is the most common and significant method for the diagnosis of lung cancer. During the COVID-19 pandemic, the indications of TBB and CTPNB must be managed strictly. Therefore, it is extremely indispensable to perform meticulous and individualized ma...
Source: Technology in Cancer Research and Treatment - October 18, 2021 Category: Cancer & Oncology Authors: Chunhua Xu Li Li Wei Wang Source Type: research

Additional Radiotherapy With or Without Chemotherapy Following Endoscopic Resection for Stage I Esophageal Carcinoma: A Pilot Study
Conclusions: For patients with stage I EC, additional radiotherapy following ER is safe and effective, with the swallowing function well-preserved. Nevertheless, prospective studies are needed to verify these results.PMID:34657505 | DOI:10.1177/15330338211048051 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - October 18, 2021 Category: Cancer & Oncology Authors: Xu Yang Yu Men Jianyang Wang Jingjing Kang Xin Sun Maoyuan Zhao Shuang Sun Meng Yuan Yongxing Bao Zeliang Ma Guiqi Wang Zhouguang Hui Source Type: research

Identification of Immune Subtypes for Predicting the Prognosis of Patients in Head and Neck Squamous Cell Carcinoma
Technol Cancer Res Treat. 2021 Jan-Dec;20:15330338211045823. doi: 10.1177/15330338211045823.ABSTRACTHead and neck squamous cell carcinoma (HNSCC) is a common malignancy with poor prognosis and immune response, which plays an important role in tumor progression. Recently, immunotherapies have revolutionized the therapeutic means of malignancies including HNSCC. However, the relationship between immunophenotypes of HNSCC and its clinical response to immune-checkpoint inhibitors remains unclear. We aim to identify molecular subtyping related to distinct immunophenotypes in HNSCC. Consensus clustering algorithm was conducted f...
Source: Technology in Cancer Research and Treatment - October 18, 2021 Category: Cancer & Oncology Authors: Jing Sun Guiqing Fang Zhibin Zuo Xijiao Yu Lande Xue Chong Li Shu Li Source Type: research

Hepatic Artery Infusion Pump Combined With Systemic Chemotherapy for Patients With Liver Metastases From Breast Carcinoma
This study aimed to evaluate the efficacy and safety of hepatic arterial infusion (HAI) combined with systemic chemotherapy in patients with breast carcinoma liver metastases (BCLM). Methods: From January 2012 to December 2019, HAI catheter systems were implanted under the guide of digital subtract angiography (DSA) in 19 patients with BCLM. All patients received systemic chemotherapy and HAI gemcitabine plus floxuridine (FUDR). Methods: The overall response rate (ORR) of intrahepatic lesions was 73.7%, including 2 patients (10.5%) with complete remission (CR) and 12 patients (63.2%) with partial remission (PR). Additional...
Source: Technology in Cancer Research and Treatment - October 18, 2021 Category: Cancer & Oncology Authors: Hong-Bing Shi Wei-Guang Qiang Wei-Liang Zhu Ye Yuan Jun-Jun Wang Jie-Min Zhao Wen-Wei Hu Source Type: research

Concurrent Comparison of the Prognostic Values of Tumor Budding, Tumor Stroma Ratio, Tumor Infiltrating Pattern and Lymphocyte-to-Monocyte Ratio in Colorectal Cancer Patients
Technol Cancer Res Treat. 2021 Jan-Dec;20:15330338211045826. doi: 10.1177/15330338211045826.ABSTRACTObjectives: Tumor budding (TB), tumor stroma ratio (TSR), tumor infiltrating pattern (TIP), and preoperative lymphocyte-to-monocyte ratio (LMR) were previously reported to be useful prognostic factors in colorectal cancer (CRC); however, the correlation among these markers and their individual prognostic potency have not been extensively studied. Methods: A cohort of 147 stage I-IV CRC patients was obtained retrospectively, and the patients were divided into subgroups based on low or high TB/TSR/LMR, TIPa (expansile + interm...
Source: Technology in Cancer Research and Treatment - October 18, 2021 Category: Cancer & Oncology Authors: Yingcheng Zhang You Liu Xiaomei Qiu Bing Yan Source Type: research

The Clinical Significance of RMI2 in Hepatocellular Carcinoma
Technol Cancer Res Treat. 2021 Jan-Dec;20:15330338211045496. doi: 10.1177/15330338211045496.ABSTRACTBackground: Hepatocellular carcinoma (HCC), which is the most common type of primary liver cancer, often presents at advanced stage with a dismal prognosis. Novel tumor biomarkers are needed to aid in HCC early detection and prognostication. Methods: Immunohistochemical staining for RecQ-mediated genome instability protein 2 (RMI2) was performed in 330 surgically resected HCC specimens and 190 adjacent normal tissues. Univariate and multivariate regression analysis were applied to identify prognostic indicators of HCC outcom...
Source: Technology in Cancer Research and Treatment - October 12, 2021 Category: Cancer & Oncology Authors: Bin Zheng Ms Heng Wang Ms Jin-Xue Wang Ms Zheng-Hong Liu Ms Pu Zhang Md Dahong Zhang Md Source Type: research

The Clinical Significance of RMI2 in Hepatocellular Carcinoma
Technol Cancer Res Treat. 2021 Jan-Dec;20:15330338211045496. doi: 10.1177/15330338211045496.ABSTRACTBackground: Hepatocellular carcinoma (HCC), which is the most common type of primary liver cancer, often presents at advanced stage with a dismal prognosis. Novel tumor biomarkers are needed to aid in HCC early detection and prognostication. Methods: Immunohistochemical staining for RecQ-mediated genome instability protein 2 (RMI2) was performed in 330 surgically resected HCC specimens and 190 adjacent normal tissues. Univariate and multivariate regression analysis were applied to identify prognostic indicators of HCC outcom...
Source: Technology in Cancer Research and Treatment - October 12, 2021 Category: Cancer & Oncology Authors: Bin Zheng Ms Heng Wang Ms Jin-Xue Wang Ms Zheng-Hong Liu Ms Pu Zhang Md Dahong Zhang Md Source Type: research

The Clinical Significance of RMI2 in Hepatocellular Carcinoma
Technol Cancer Res Treat. 2021 Jan-Dec;20:15330338211045496. doi: 10.1177/15330338211045496.ABSTRACTBackground: Hepatocellular carcinoma (HCC), which is the most common type of primary liver cancer, often presents at advanced stage with a dismal prognosis. Novel tumor biomarkers are needed to aid in HCC early detection and prognostication. Methods: Immunohistochemical staining for RecQ-mediated genome instability protein 2 (RMI2) was performed in 330 surgically resected HCC specimens and 190 adjacent normal tissues. Univariate and multivariate regression analysis were applied to identify prognostic indicators of HCC outcom...
Source: Technology in Cancer Research and Treatment - October 12, 2021 Category: Cancer & Oncology Authors: Bin Zheng Ms Heng Wang Ms Jin-Xue Wang Ms Zheng-Hong Liu Ms Pu Zhang Md Dahong Zhang Md Source Type: research

The Clinical Significance of RMI2 in Hepatocellular Carcinoma
Technol Cancer Res Treat. 2021 Jan-Dec;20:15330338211045496. doi: 10.1177/15330338211045496.ABSTRACTBackground: Hepatocellular carcinoma (HCC), which is the most common type of primary liver cancer, often presents at advanced stage with a dismal prognosis. Novel tumor biomarkers are needed to aid in HCC early detection and prognostication. Methods: Immunohistochemical staining for RecQ-mediated genome instability protein 2 (RMI2) was performed in 330 surgically resected HCC specimens and 190 adjacent normal tissues. Univariate and multivariate regression analysis were applied to identify prognostic indicators of HCC outcom...
Source: Technology in Cancer Research and Treatment - October 12, 2021 Category: Cancer & Oncology Authors: Bin Zheng Ms Heng Wang Ms Jin-Xue Wang Ms Zheng-Hong Liu Ms Pu Zhang Md Dahong Zhang Md Source Type: research

The Clinical Significance of RMI2 in Hepatocellular Carcinoma
Technol Cancer Res Treat. 2021 Jan-Dec;20:15330338211045496. doi: 10.1177/15330338211045496.ABSTRACTBackground: Hepatocellular carcinoma (HCC), which is the most common type of primary liver cancer, often presents at advanced stage with a dismal prognosis. Novel tumor biomarkers are needed to aid in HCC early detection and prognostication. Methods: Immunohistochemical staining for RecQ-mediated genome instability protein 2 (RMI2) was performed in 330 surgically resected HCC specimens and 190 adjacent normal tissues. Univariate and multivariate regression analysis were applied to identify prognostic indicators of HCC outcom...
Source: Technology in Cancer Research and Treatment - October 12, 2021 Category: Cancer & Oncology Authors: Bin Zheng Ms Heng Wang Ms Jin-Xue Wang Ms Zheng-Hong Liu Ms Pu Zhang Md Dahong Zhang Md Source Type: research

Ovarian Function Preservation in Patients With Cervical Cancer Undergoing Hysterectomy and Ovarian Transposition Before Pelvic Radiotherapy
Technol Cancer Res Treat. 2021 Jan-Dec;20:15330338211042140. doi: 10.1177/15330338211042140.ABSTRACTTo examine the factors associated with ovarian failure (OF) and assess the effectiveness of ovarian transposition (OT) before pelvic irradiation for preserving ovarian function in patients with cervical cancer (CC) undergoing hysterectomy. During 2003 to 2017, patients who underwent hysterectomy with preservation of one or both ovaries were retrospectively enrolled. Patients were divided into 4 groups, depending on whether radiotherapy (RT) and OT were performed: group 1, RT(+) and OT(+); group 2, RT(+) and OT(-); group 3, R...
Source: Technology in Cancer Research and Treatment - October 11, 2021 Category: Cancer & Oncology Authors: Wonguen Jung Yun H Kim Kyung S Kim Source Type: research

Diagnostic and Therapeutic Potential of Extracellular Vesicles
Technol Cancer Res Treat. 2021 Jan-Dec;20:15330338211041203. doi: 10.1177/15330338211041203.ABSTRACTExtracellular vesicles (EVs) are naturally phospholipid enclosed nanovesicles released by many cells in the body. They are stable in circulation, have low immunogenicity, and act as carriers for functionally active biological molecules. They interact with target organs and bind to the receptors. Their target specificity is important to use EVs as noninvasive diagnostic and prognostic tools. EVs play a vital role in normal physiology and cellular communication. They are known to protect their cargo from degradation, which mak...
Source: Technology in Cancer Research and Treatment - October 11, 2021 Category: Cancer & Oncology Authors: Sai Priyanka Kodam Mujib Ullah Source Type: research

Targeting Accuracy Considerations for Simultaneous Tumor Treating Fields Antimitotic Therapy During Robotic Hypofractionated Radiation Therapy
Conclusion: A robotic radiosurgery system was used to verify that radiation targeting was not adversely affected when the TTFields arrays were in place and the TTFields delivery device was powered on. In addition, this study verified that radiation delivered simultaneously with TTFields did not interfere with the generation of the electric fields.PMID:34632866 | DOI:10.1177/15330338211039135 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - October 11, 2021 Category: Cancer & Oncology Authors: Sharmi Biswas Irina Kapitanova Sabrina Divekar Jimm Grimm Ian J Butterwick Daniel Garren Lawrence R Kleinberg Kristin J Redmond Michel Lacroix Anand Mahadevan Kenneth M Forster Source Type: research

The Capabilities and Characteristics of Helical Tomotherapy and Co-Planar Dual Arcs Volumetric-Modulated arc Therapy Associated with Hippocampal Sparing During Prophylactic Cranial Irradiation
Technol Cancer Res Treat. 2021 Jan-Dec;20:15330338211043975. doi: 10.1177/15330338211043975.ABSTRACTObjective: To investigate the features of helical tomotherapy and co-planar dual Arcs volumetric-modulated arc therapy during prophylactic cranial irradiation associated with bilateral hippocampal tissue sparing. Materials and methods: Helical tomotherapy and co-planar dual arcs volumetric-modulated arc therapy treatment plans were generated with a dose of 30 Gy/10 fractions in 16 patients treated with prophylactic cranial irradiation. The dose to the bilateral hippocampal tissues, organs at risk, and planning target volume ...
Source: Technology in Cancer Research and Treatment - October 11, 2021 Category: Cancer & Oncology Authors: Dandan Wang Xingmin Ma Lu Fu Jiabing Gu Tong Bai Yong Yin Baosheng Li Jian Zhu Source Type: research

Effect of Programmed Death-Ligand 1 in Cancer-Associated Fibroblasts on Advanced Laryngeal Squamous Cell Carcinoma
This study aimed to explore the effect of programmed death-ligand 1 (PD-L1) in cancer-associated fibroblasts (CAFs) on advanced laryngeal squamous cell carcinoma (LSCC). The expression of PD-L1 in advanced LSCC tumor tissues was observed in 83 patients with LSCC by immunofluorescence microscopy and compared with that in normal laryngeal mucosa. The CAFs of LSCC and normal fibroblasts (NFs) were isolated, cultured, purified, and examined by fluorescence. The expression of PD-L1 in purified CAFs and NFs was measured by flow cytometry. The expression of PD-L1 in CAFs was downregulated through small interferring RNA (siRNA) tr...
Source: Technology in Cancer Research and Treatment - October 11, 2021 Category: Cancer & Oncology Authors: Zhendong Yang Jinxin Wang Chun Chen Peng Sun Yafeng Yu Source Type: research

Monte Carlo Dose Calculation Using MRI Based Synthetic CT Generated by Fully Convolutional Neural Network for Gamma Knife Radiosurgery
Technol Cancer Res Treat. 2021 Jan-Dec;20:15330338211046433. doi: 10.1177/15330338211046433.ABSTRACTThe aim of this work is to study the dosimetric effect from generated synthetic computed tomography (sCT) from magnetic resonance (MR) images using a deep learning algorithm for Gamma Knife (GK) stereotactic radiosurgery (SRS). The Monte Carlo (MC) method is used for dose calculations. Thirty patients were retrospectively selected with our institution IRB's approval. All patients were treated with GK SRS based on T1-weighted MR images and also underwent conventional external beam treatment with a CT scan. Image datasets were...
Source: Technology in Cancer Research and Treatment - October 11, 2021 Category: Cancer & Oncology Authors: Jiankui Yuan Elisha Fredman Jian-Yue Jin Serah Choi David Mansur Andrew Sloan Mitchell Machtay Yiran Zheng Source Type: research

Influence of Modulation Factor on Treatment Plan Quality and Irradiation Time in Hippocampus-Sparing Whole-Brain Radiotherapy Using Tomotherapy
Conclusions: When HS-WBRT is performed with a tilted body position and a jaw width of 1 cm, with a MF of 1.8, a favorable balance between dose parameters and irradiation time is achieved, whereas with a MF of 1.4, the quality of the radiotherapy plan deteriorates, and the irradiation time is approximately the same as that with a MF of 1.8.PMID:34632876 | DOI:10.1177/15330338211045497 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - October 11, 2021 Category: Cancer & Oncology Authors: Akihiko Ishibashi Hiromasa Kurosaki Kosei Miura Nobuko Utsumi Hideyuki Sakurai Source Type: research

Ovarian Function Preservation in Patients With Cervical Cancer Undergoing Hysterectomy and Ovarian Transposition Before Pelvic Radiotherapy
Technol Cancer Res Treat. 2021 Jan-Dec;20:15330338211042140. doi: 10.1177/15330338211042140.ABSTRACTTo examine the factors associated with ovarian failure (OF) and assess the effectiveness of ovarian transposition (OT) before pelvic irradiation for preserving ovarian function in patients with cervical cancer (CC) undergoing hysterectomy. During 2003 to 2017, patients who underwent hysterectomy with preservation of one or both ovaries were retrospectively enrolled. Patients were divided into 4 groups, depending on whether radiotherapy (RT) and OT were performed: group 1, RT(+) and OT(+); group 2, RT(+) and OT(-); group 3, R...
Source: Technology in Cancer Research and Treatment - October 11, 2021 Category: Cancer & Oncology Authors: Wonguen Jung Yun H Kim Kyung S Kim Source Type: research

Diagnostic and Therapeutic Potential of Extracellular Vesicles
Technol Cancer Res Treat. 2021 Jan-Dec;20:15330338211041203. doi: 10.1177/15330338211041203.ABSTRACTExtracellular vesicles (EVs) are naturally phospholipid enclosed nanovesicles released by many cells in the body. They are stable in circulation, have low immunogenicity, and act as carriers for functionally active biological molecules. They interact with target organs and bind to the receptors. Their target specificity is important to use EVs as noninvasive diagnostic and prognostic tools. EVs play a vital role in normal physiology and cellular communication. They are known to protect their cargo from degradation, which mak...
Source: Technology in Cancer Research and Treatment - October 11, 2021 Category: Cancer & Oncology Authors: Sai Priyanka Kodam Mujib Ullah Source Type: research

Targeting Accuracy Considerations for Simultaneous Tumor Treating Fields Antimitotic Therapy During Robotic Hypofractionated Radiation Therapy
Conclusion: A robotic radiosurgery system was used to verify that radiation targeting was not adversely affected when the TTFields arrays were in place and the TTFields delivery device was powered on. In addition, this study verified that radiation delivered simultaneously with TTFields did not interfere with the generation of the electric fields.PMID:34632866 | DOI:10.1177/15330338211039135 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - October 11, 2021 Category: Cancer & Oncology Authors: Sharmi Biswas Irina Kapitanova Sabrina Divekar Jimm Grimm Ian J Butterwick Daniel Garren Lawrence R Kleinberg Kristin J Redmond Michel Lacroix Anand Mahadevan Kenneth M Forster Source Type: research

The Capabilities and Characteristics of Helical Tomotherapy and Co-Planar Dual Arcs Volumetric-Modulated arc Therapy Associated with Hippocampal Sparing During Prophylactic Cranial Irradiation
Technol Cancer Res Treat. 2021 Jan-Dec;20:15330338211043975. doi: 10.1177/15330338211043975.ABSTRACTObjective: To investigate the features of helical tomotherapy and co-planar dual Arcs volumetric-modulated arc therapy during prophylactic cranial irradiation associated with bilateral hippocampal tissue sparing. Materials and methods: Helical tomotherapy and co-planar dual arcs volumetric-modulated arc therapy treatment plans were generated with a dose of 30 Gy/10 fractions in 16 patients treated with prophylactic cranial irradiation. The dose to the bilateral hippocampal tissues, organs at risk, and planning target volume ...
Source: Technology in Cancer Research and Treatment - October 11, 2021 Category: Cancer & Oncology Authors: Dandan Wang Xingmin Ma Lu Fu Jiabing Gu Tong Bai Yong Yin Baosheng Li Jian Zhu Source Type: research

Effect of Programmed Death-Ligand 1 in Cancer-Associated Fibroblasts on Advanced Laryngeal Squamous Cell Carcinoma
This study aimed to explore the effect of programmed death-ligand 1 (PD-L1) in cancer-associated fibroblasts (CAFs) on advanced laryngeal squamous cell carcinoma (LSCC). The expression of PD-L1 in advanced LSCC tumor tissues was observed in 83 patients with LSCC by immunofluorescence microscopy and compared with that in normal laryngeal mucosa. The CAFs of LSCC and normal fibroblasts (NFs) were isolated, cultured, purified, and examined by fluorescence. The expression of PD-L1 in purified CAFs and NFs was measured by flow cytometry. The expression of PD-L1 in CAFs was downregulated through small interferring RNA (siRNA) tr...
Source: Technology in Cancer Research and Treatment - October 11, 2021 Category: Cancer & Oncology Authors: Zhendong Yang Jinxin Wang Chun Chen Peng Sun Yafeng Yu Source Type: research

Monte Carlo Dose Calculation Using MRI Based Synthetic CT Generated by Fully Convolutional Neural Network for Gamma Knife Radiosurgery
Technol Cancer Res Treat. 2021 Jan-Dec;20:15330338211046433. doi: 10.1177/15330338211046433.ABSTRACTThe aim of this work is to study the dosimetric effect from generated synthetic computed tomography (sCT) from magnetic resonance (MR) images using a deep learning algorithm for Gamma Knife (GK) stereotactic radiosurgery (SRS). The Monte Carlo (MC) method is used for dose calculations. Thirty patients were retrospectively selected with our institution IRB's approval. All patients were treated with GK SRS based on T1-weighted MR images and also underwent conventional external beam treatment with a CT scan. Image datasets were...
Source: Technology in Cancer Research and Treatment - October 11, 2021 Category: Cancer & Oncology Authors: Jiankui Yuan Elisha Fredman Jian-Yue Jin Serah Choi David Mansur Andrew Sloan Mitchell Machtay Yiran Zheng Source Type: research

Influence of Modulation Factor on Treatment Plan Quality and Irradiation Time in Hippocampus-Sparing Whole-Brain Radiotherapy Using Tomotherapy
Conclusions: When HS-WBRT is performed with a tilted body position and a jaw width of 1 cm, with a MF of 1.8, a favorable balance between dose parameters and irradiation time is achieved, whereas with a MF of 1.4, the quality of the radiotherapy plan deteriorates, and the irradiation time is approximately the same as that with a MF of 1.8.PMID:34632876 | DOI:10.1177/15330338211045497 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - October 11, 2021 Category: Cancer & Oncology Authors: Akihiko Ishibashi Hiromasa Kurosaki Kosei Miura Nobuko Utsumi Hideyuki Sakurai Source Type: research

EIF3B Associates with Exacerbated Clinical Features, Poor Treatment Response and Survival in Adult Philadelphia Chromosome Negative Acute Lymphoblastic Leukemia Patients
Conclusion: EIF3B overexpression is related to worsened clinical features, poor treatment response and survival in adult Ph- ALL patients.PMID:34617851 | DOI:10.1177/15330338211041464 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - October 7, 2021 Category: Cancer & Oncology Authors: Feiyue Zhu Yesong Fu Xiaojuan He Source Type: research

Prognostic Role of Carbohydrate Antigen 19 to 9 in Predicting Survival of Patients With Pancreatic Cancer: A Meta-Analysis
This study evaluates the prognostic role of carbohydrate antigen 19 to 9 (CA19-9) in predicting survival of pancreatic cancer patients. Literature search was conducted in electronic databases (Google Scholar, Ovid, PubMed, and Science Direct) and study selection was based on precise eligibility criteria. Random-effects meta-analyses were performed to achieve overall estimates of median survival and hazard ratios (HRs) of survival with cutoff defined lower and higher CA19-9 levels before and after surgery or chemotherapy (CT)/radiotherapy (RT) and the changes in CA19-9 levels after any treatment. A total of 41 studies (6519...
Source: Technology in Cancer Research and Treatment - October 7, 2021 Category: Cancer & Oncology Authors: Yong-Ming Kang Hao Wang Ran Li Gu Pan Source Type: research

Comparative Evaluation of 4-Dimensional Computed Tomography and 4-Dimensional Magnetic Resonance Imaging to Delineate the Target of Primary Liver Cancer
Conclusions: Compared with 4DCT, T2-weighted and navigator-triggered 4DMRI produces fewer artifacts and larger motion differences in hepatic intrafraction tumors, which is a feasible technique for primary liver cancer treatment planning.PMID:34617855 | DOI:10.1177/15330338211045499 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - October 7, 2021 Category: Cancer & Oncology Authors: Yukai Chen Guanzhong Gong Yinxing Wang Chenlu Liu Ya Su Lizhen Wang Bo Yang Yong Yin Source Type: research