Long Non-Coding RNA LOC648987 Promotes Proliferation and Metastasis of Renal Cell Carcinoma by Regulating Epithelial-Mesenchymal Transition
Technol Cancer Res Treat. 2021 Jan-Dec;20:1533033821997834. doi: 10.1177/1533033821997834.ABSTRACTRenal cell carcinoma (RCC) is a type of urinary tumor with a high incidence and is often associated with tumor metastasis. Long non-coding RNA (lncRNA) regulates tumorigenesis, progression, and metastasis. However, the role and the predictive value of lncRNA in RCC progression and metastasis have not been elucidated. The purpose of this study was to evaluate the effect of a newly discovered lncRNA LOC648987 on RCC proliferation and metastasis. LOC648987 was identified by RT-PCR for high expression in human RCC tissues as well ...
Source: Technology in Cancer Research and Treatment - April 16, 2021 Category: Cancer & Oncology Authors: Yaowu Su Liang Zhou Qin Yu Jianjun Lu Wei Liu Source Type: research

Long Non-Coding RNA LOC648987 Promotes Proliferation and Metastasis of Renal Cell Carcinoma by Regulating Epithelial-Mesenchymal Transition
Technol Cancer Res Treat. 2021 Jan-Dec;20:1533033821997834. doi: 10.1177/1533033821997834.ABSTRACTRenal cell carcinoma (RCC) is a type of urinary tumor with a high incidence and is often associated with tumor metastasis. Long non-coding RNA (lncRNA) regulates tumorigenesis, progression, and metastasis. However, the role and the predictive value of lncRNA in RCC progression and metastasis have not been elucidated. The purpose of this study was to evaluate the effect of a newly discovered lncRNA LOC648987 on RCC proliferation and metastasis. LOC648987 was identified by RT-PCR for high expression in human RCC tissues as well ...
Source: Technology in Cancer Research and Treatment - April 16, 2021 Category: Cancer & Oncology Authors: Yaowu Su Liang Zhou Qin Yu Jianjun Lu Wei Liu Source Type: research

MiR-155 Inhibits Malignant Biological Behavior of Human Liver Cancer Cells by Regulating SRPK1
We report the abnormal expression of the miR-155 cluster in liver cancer cells, which inhibits cancer cell proliferation and metastasis. In addition, we identified SRPK1 as a target gene of miR-155 during the process of liver cancer cell proliferation and metastasis.PMID:33827350 | DOI:10.1177/1533033820957021 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - April 8, 2021 Category: Cancer & Oncology Authors: Qi Wang Guo-Tai Wang Wei-Hong Lu Source Type: research

MiR-155 Inhibits Malignant Biological Behavior of Human Liver Cancer Cells by Regulating SRPK1
We report the abnormal expression of the miR-155 cluster in liver cancer cells, which inhibits cancer cell proliferation and metastasis. In addition, we identified SRPK1 as a target gene of miR-155 during the process of liver cancer cell proliferation and metastasis.PMID:33827350 | DOI:10.1177/1533033820957021 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - April 8, 2021 Category: Cancer & Oncology Authors: Qi Wang Guo-Tai Wang Wei-Hong Lu Source Type: research

MiR-155 Inhibits Malignant Biological Behavior of Human Liver Cancer Cells by Regulating SRPK1
We report the abnormal expression of the miR-155 cluster in liver cancer cells, which inhibits cancer cell proliferation and metastasis. In addition, we identified SRPK1 as a target gene of miR-155 during the process of liver cancer cell proliferation and metastasis.PMID:33827350 | DOI:10.1177/1533033820957021 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - April 8, 2021 Category: Cancer & Oncology Authors: Qi Wang Guo-Tai Wang Wei-Hong Lu Source Type: research

MiR-155 Inhibits Malignant Biological Behavior of Human Liver Cancer Cells by Regulating SRPK1
We report the abnormal expression of the miR-155 cluster in liver cancer cells, which inhibits cancer cell proliferation and metastasis. In addition, we identified SRPK1 as a target gene of miR-155 during the process of liver cancer cell proliferation and metastasis.PMID:33827350 | DOI:10.1177/1533033820957021 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - April 8, 2021 Category: Cancer & Oncology Authors: Qi Wang Guo-Tai Wang Wei-Hong Lu Source Type: research

MiR-155 Inhibits Malignant Biological Behavior of Human Liver Cancer Cells by Regulating SRPK1
We report the abnormal expression of the miR-155 cluster in liver cancer cells, which inhibits cancer cell proliferation and metastasis. In addition, we identified SRPK1 as a target gene of miR-155 during the process of liver cancer cell proliferation and metastasis.PMID:33827350 | DOI:10.1177/1533033820957021 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - April 8, 2021 Category: Cancer & Oncology Authors: Qi Wang Guo-Tai Wang Wei-Hong Lu Source Type: research

MiR-155 Inhibits Malignant Biological Behavior of Human Liver Cancer Cells by Regulating SRPK1
We report the abnormal expression of the miR-155 cluster in liver cancer cells, which inhibits cancer cell proliferation and metastasis. In addition, we identified SRPK1 as a target gene of miR-155 during the process of liver cancer cell proliferation and metastasis.PMID:33827350 | DOI:10.1177/1533033820957021 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - April 8, 2021 Category: Cancer & Oncology Authors: Qi Wang Guo-Tai Wang Wei-Hong Lu Source Type: research

Knockdown of lncRNA HOTTIP Inhibits Retinoblastoma Progression by Modulating the miR-101-3p/STC1 Axis
CONCLUSION: It could be concluded that HOTTIP sponged miR-101-3p to upregulate STC1 expression, thereby promoting RB cell proliferation and inhibiting apoptosis.PMID:33784880 | DOI:10.1177/1533033821997831 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - March 31, 2021 Category: Cancer & Oncology Authors: XiangWen Yuan Zhaoyan Sun Congxian Cui Source Type: research

LAMB1 Is Related to the T Stage and Indicates Poor Prognosis in Gastric Cancer
CONCLUSIONS: The high expression of LAMB1 in gastric cancer is related to the poor prognosis of patients, and it may be related to microenvironmental changes in tumors.PMID:33784890 | DOI:10.1177/15330338211004944 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - March 31, 2021 Category: Cancer & Oncology Authors: Tao Ran ZhiJi Chen LiWen Zhao Wei Ran JinYu Fan SiYa Hong ZhaoXia Yang Source Type: research

A Novel 85-Gene Expression Signature Predicts Unfavorable Prognosis in Acute Myeloid Leukemia
CONCLUSIONS: The 85-gene score is superior to the 2 established prognostic gene signatures in the prediction of prognosis of AML patients.PMID:33784904 | DOI:10.1177/15330338211004933 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - March 31, 2021 Category: Cancer & Oncology Authors: Yanli Lai Lixia Sheng Jiaping Wang Miao Zhou Guifang OuYang Source Type: research

Knockdown of lncRNA HOTTIP Inhibits Retinoblastoma Progression by Modulating the miR-101-3p/STC1 Axis
CONCLUSION: It could be concluded that HOTTIP sponged miR-101-3p to upregulate STC1 expression, thereby promoting RB cell proliferation and inhibiting apoptosis.PMID:33784880 | DOI:10.1177/1533033821997831 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - March 31, 2021 Category: Cancer & Oncology Authors: XiangWen Yuan Zhaoyan Sun Congxian Cui Source Type: research

LAMB1 Is Related to the T Stage and Indicates Poor Prognosis in Gastric Cancer
CONCLUSIONS: The high expression of LAMB1 in gastric cancer is related to the poor prognosis of patients, and it may be related to microenvironmental changes in tumors.PMID:33784890 | DOI:10.1177/15330338211004944 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - March 31, 2021 Category: Cancer & Oncology Authors: Tao Ran ZhiJi Chen LiWen Zhao Wei Ran JinYu Fan SiYa Hong ZhaoXia Yang Source Type: research

A Novel 85-Gene Expression Signature Predicts Unfavorable Prognosis in Acute Myeloid Leukemia
CONCLUSIONS: The 85-gene score is superior to the 2 established prognostic gene signatures in the prediction of prognosis of AML patients.PMID:33784904 | DOI:10.1177/15330338211004933 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - March 31, 2021 Category: Cancer & Oncology Authors: Yanli Lai Lixia Sheng Jiaping Wang Miao Zhou Guifang OuYang Source Type: research

Knockdown of lncRNA HOTTIP Inhibits Retinoblastoma Progression by Modulating the miR-101-3p/STC1 Axis
CONCLUSION: It could be concluded that HOTTIP sponged miR-101-3p to upregulate STC1 expression, thereby promoting RB cell proliferation and inhibiting apoptosis.PMID:33784880 | DOI:10.1177/1533033821997831 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - March 31, 2021 Category: Cancer & Oncology Authors: XiangWen Yuan Zhaoyan Sun Congxian Cui Source Type: research

LAMB1 Is Related to the T Stage and Indicates Poor Prognosis in Gastric Cancer
CONCLUSIONS: The high expression of LAMB1 in gastric cancer is related to the poor prognosis of patients, and it may be related to microenvironmental changes in tumors.PMID:33784890 | DOI:10.1177/15330338211004944 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - March 31, 2021 Category: Cancer & Oncology Authors: Tao Ran ZhiJi Chen LiWen Zhao Wei Ran JinYu Fan SiYa Hong ZhaoXia Yang Source Type: research

A Novel 85-Gene Expression Signature Predicts Unfavorable Prognosis in Acute Myeloid Leukemia
CONCLUSIONS: The 85-gene score is superior to the 2 established prognostic gene signatures in the prediction of prognosis of AML patients.PMID:33784904 | DOI:10.1177/15330338211004933 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - March 31, 2021 Category: Cancer & Oncology Authors: Yanli Lai Lixia Sheng Jiaping Wang Miao Zhou Guifang OuYang Source Type: research

Knockdown of lncRNA HOTTIP Inhibits Retinoblastoma Progression by Modulating the miR-101-3p/STC1 Axis
CONCLUSION: It could be concluded that HOTTIP sponged miR-101-3p to upregulate STC1 expression, thereby promoting RB cell proliferation and inhibiting apoptosis.PMID:33784880 | DOI:10.1177/1533033821997831 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - March 31, 2021 Category: Cancer & Oncology Authors: XiangWen Yuan Zhaoyan Sun Congxian Cui Source Type: research

LAMB1 Is Related to the T Stage and Indicates Poor Prognosis in Gastric Cancer
CONCLUSIONS: The high expression of LAMB1 in gastric cancer is related to the poor prognosis of patients, and it may be related to microenvironmental changes in tumors.PMID:33784890 | DOI:10.1177/15330338211004944 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - March 31, 2021 Category: Cancer & Oncology Authors: Tao Ran ZhiJi Chen LiWen Zhao Wei Ran JinYu Fan SiYa Hong ZhaoXia Yang Source Type: research

A Novel 85-Gene Expression Signature Predicts Unfavorable Prognosis in Acute Myeloid Leukemia
CONCLUSIONS: The 85-gene score is superior to the 2 established prognostic gene signatures in the prediction of prognosis of AML patients.PMID:33784904 | DOI:10.1177/15330338211004933 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - March 31, 2021 Category: Cancer & Oncology Authors: Yanli Lai Lixia Sheng Jiaping Wang Miao Zhou Guifang OuYang Source Type: research

Knockdown of lncRNA HOTTIP Inhibits Retinoblastoma Progression by Modulating the miR-101-3p/STC1 Axis
CONCLUSION: It could be concluded that HOTTIP sponged miR-101-3p to upregulate STC1 expression, thereby promoting RB cell proliferation and inhibiting apoptosis.PMID:33784880 | DOI:10.1177/1533033821997831 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - March 31, 2021 Category: Cancer & Oncology Authors: XiangWen Yuan Zhaoyan Sun Congxian Cui Source Type: research

LAMB1 Is Related to the T Stage and Indicates Poor Prognosis in Gastric Cancer
CONCLUSIONS: The high expression of LAMB1 in gastric cancer is related to the poor prognosis of patients, and it may be related to microenvironmental changes in tumors.PMID:33784890 | DOI:10.1177/15330338211004944 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - March 31, 2021 Category: Cancer & Oncology Authors: Tao Ran ZhiJi Chen LiWen Zhao Wei Ran JinYu Fan SiYa Hong ZhaoXia Yang Source Type: research

A Novel 85-Gene Expression Signature Predicts Unfavorable Prognosis in Acute Myeloid Leukemia
CONCLUSIONS: The 85-gene score is superior to the 2 established prognostic gene signatures in the prediction of prognosis of AML patients.PMID:33784904 | DOI:10.1177/15330338211004933 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - March 31, 2021 Category: Cancer & Oncology Authors: Yanli Lai Lixia Sheng Jiaping Wang Miao Zhou Guifang OuYang Source Type: research

Knockdown of lncRNA HOTTIP Inhibits Retinoblastoma Progression by Modulating the miR-101-3p/STC1 Axis
CONCLUSION: It could be concluded that HOTTIP sponged miR-101-3p to upregulate STC1 expression, thereby promoting RB cell proliferation and inhibiting apoptosis.PMID:33784880 | DOI:10.1177/1533033821997831 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - March 31, 2021 Category: Cancer & Oncology Authors: XiangWen Yuan Zhaoyan Sun Congxian Cui Source Type: research

LAMB1 Is Related to the T Stage and Indicates Poor Prognosis in Gastric Cancer
CONCLUSIONS: The high expression of LAMB1 in gastric cancer is related to the poor prognosis of patients, and it may be related to microenvironmental changes in tumors.PMID:33784890 | DOI:10.1177/15330338211004944 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - March 31, 2021 Category: Cancer & Oncology Authors: Tao Ran ZhiJi Chen LiWen Zhao Wei Ran JinYu Fan SiYa Hong ZhaoXia Yang Source Type: research

A Novel 85-Gene Expression Signature Predicts Unfavorable Prognosis in Acute Myeloid Leukemia
CONCLUSIONS: The 85-gene score is superior to the 2 established prognostic gene signatures in the prediction of prognosis of AML patients.PMID:33784904 | DOI:10.1177/15330338211004933 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - March 31, 2021 Category: Cancer & Oncology Authors: Yanli Lai Lixia Sheng Jiaping Wang Miao Zhou Guifang OuYang Source Type: research

Knockdown of lncRNA HOTTIP Inhibits Retinoblastoma Progression by Modulating the miR-101-3p/STC1 Axis
CONCLUSION: It could be concluded that HOTTIP sponged miR-101-3p to upregulate STC1 expression, thereby promoting RB cell proliferation and inhibiting apoptosis.PMID:33784880 | DOI:10.1177/1533033821997831 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - March 31, 2021 Category: Cancer & Oncology Authors: XiangWen Yuan Zhaoyan Sun Congxian Cui Source Type: research

LAMB1 Is Related to the T Stage and Indicates Poor Prognosis in Gastric Cancer
CONCLUSIONS: The high expression of LAMB1 in gastric cancer is related to the poor prognosis of patients, and it may be related to microenvironmental changes in tumors.PMID:33784890 | DOI:10.1177/15330338211004944 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - March 31, 2021 Category: Cancer & Oncology Authors: Tao Ran ZhiJi Chen LiWen Zhao Wei Ran JinYu Fan SiYa Hong ZhaoXia Yang Source Type: research

A Novel 85-Gene Expression Signature Predicts Unfavorable Prognosis in Acute Myeloid Leukemia
CONCLUSIONS: The 85-gene score is superior to the 2 established prognostic gene signatures in the prediction of prognosis of AML patients.PMID:33784904 | DOI:10.1177/15330338211004933 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - March 31, 2021 Category: Cancer & Oncology Authors: Yanli Lai Lixia Sheng Jiaping Wang Miao Zhou Guifang OuYang Source Type: research

FGFR1 Is Associated With Tamoxifen Resistance and Poor Prognosis of ER-Positive Breast Cancers by Suppressing ER Protein Expression
In conclusion, we found that there was a significant negative correlation between FGFR1 and ER levels in ER+ breast cancers, high FGFR1 protein expression was associated with poor breast cancer prognosis, down-regulating FGFR1 could elevate ER expression and is associated with enhanced TAM sensitivity in ER+ breast cancers.PMID:33783288 | DOI:10.1177/15330338211004935 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - March 30, 2021 Category: Cancer & Oncology Authors: Qing Lv Shiming Guan Mingjie Zhu Hu Huang Junqiang Wu Xiaofeng Dai Source Type: research

Research Progress and Application Prospects of Long Noncoding RNAs in Gastric Neoplasms
This article reviews lncRNAs and the mechanisms that have been discovered in recent years related to gastrointestinal tumors.PMID:33769145 | DOI:10.1177/15330338211004940 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - March 26, 2021 Category: Cancer & Oncology Authors: Bibo Tan Fang Li Zihao Chen Yong Li Source Type: research

Research Progress and Application Prospects of Long Noncoding RNAs in Gastric Neoplasms
This article reviews lncRNAs and the mechanisms that have been discovered in recent years related to gastrointestinal tumors.PMID:33769145 | DOI:10.1177/15330338211004940 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - March 26, 2021 Category: Cancer & Oncology Authors: Bibo Tan Fang Li Zihao Chen Yong Li Source Type: research

Research Progress and Application Prospects of Long Noncoding RNAs in Gastric Neoplasms
This article reviews lncRNAs and the mechanisms that have been discovered in recent years related to gastrointestinal tumors.PMID:33769145 | DOI:10.1177/15330338211004940 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - March 26, 2021 Category: Cancer & Oncology Authors: Bibo Tan Fang Li Zihao Chen Yong Li Source Type: research

Research Progress and Application Prospects of Long Noncoding RNAs in Gastric Neoplasms
This article reviews lncRNAs and the mechanisms that have been discovered in recent years related to gastrointestinal tumors.PMID:33769145 | DOI:10.1177/15330338211004940 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - March 26, 2021 Category: Cancer & Oncology Authors: Bibo Tan Fang Li Zihao Chen Yong Li Source Type: research

PD-1 Immune Checkpoint Inhibitor Therapy Malignant Tumor Based on Monotherapy and Combined Treatment Research
Technol Cancer Res Treat. 2021 Jan-Dec;20:15330338211004942. doi: 10.1177/15330338211004942.ABSTRACTRecently, immunotherapy has become the fourth pillar of cancer treatment in addition to surgery therapy, chemotherapy, and radiation therapy. The inhibitors of programed cell death protein 1 (PD-1) and its ligand PD-L1 are the new stars in immunotherapy, as they can overcome tumor immunosuppression. However, the efficacy of PD-1 inhibitors still needs to be further developed for clinical treatment. Therefore, research into treatment with anti-PD-1 drugs has emerged as a new development field. This review provides novel insig...
Source: Technology in Cancer Research and Treatment - March 24, 2021 Category: Cancer & Oncology Authors: Yu Zhang Guang-Ze Mou Tian-Zhu Li Wan-Ting Xu Tong Zhang Hui Xue Wen-Bo Zuo Yan-Nan Li Ying-Hua Luo Cheng-Hao Jin Source Type: research

Knockdown of circ_NEK6 Decreased < sup > 131 < /sup > I Resistance of Differentiated Thyroid Carcinoma via Regulating miR-370-3p/MYH9 Axis
This study aimed to explore the effect of circ_NEK6 on the development of 131I resistance in DTC and its potential mechanism. In this study, we demonstrated that circ_NEK6 expression was significantly elevated in 131I-resistant DTC tissues and cell lines. Knockdown of circ_NEK6 significantly repressed 131I resistance via inhibiting cell proliferation, migration, invasion abilities, and inducing cell apoptosis and DNA damage in 131I-resistant DTC cells. Mechanistically, knockdown of circ_NEK6 suppressed 131I resistance in DTC by upregulating the inhibitory effect of miR-370-3p on the expression of myosin heavy chain 9 (MYH9...
Source: Technology in Cancer Research and Treatment - March 24, 2021 Category: Cancer & Oncology Authors: Fukun Chen Shuting Yin Zhiping Feng Chao Liu Juan Lv Yuanjiao Chen Ruoxia Shen Jiaping Wang Zhiyong Deng Source Type: research

PD-1 Immune Checkpoint Inhibitor Therapy Malignant Tumor Based on Monotherapy and Combined Treatment Research
Technol Cancer Res Treat. 2021 Jan-Dec;20:15330338211004942. doi: 10.1177/15330338211004942.ABSTRACTRecently, immunotherapy has become the fourth pillar of cancer treatment in addition to surgery therapy, chemotherapy, and radiation therapy. The inhibitors of programed cell death protein 1 (PD-1) and its ligand PD-L1 are the new stars in immunotherapy, as they can overcome tumor immunosuppression. However, the efficacy of PD-1 inhibitors still needs to be further developed for clinical treatment. Therefore, research into treatment with anti-PD-1 drugs has emerged as a new development field. This review provides novel insig...
Source: Technology in Cancer Research and Treatment - March 24, 2021 Category: Cancer & Oncology Authors: Yu Zhang Guang-Ze Mou Tian-Zhu Li Wan-Ting Xu Tong Zhang Hui Xue Wen-Bo Zuo Yan-Nan Li Ying-Hua Luo Cheng-Hao Jin Source Type: research

Knockdown of circ_NEK6 Decreased < sup > 131 < /sup > I Resistance of Differentiated Thyroid Carcinoma via Regulating miR-370-3p/MYH9 Axis
This study aimed to explore the effect of circ_NEK6 on the development of 131I resistance in DTC and its potential mechanism. In this study, we demonstrated that circ_NEK6 expression was significantly elevated in 131I-resistant DTC tissues and cell lines. Knockdown of circ_NEK6 significantly repressed 131I resistance via inhibiting cell proliferation, migration, invasion abilities, and inducing cell apoptosis and DNA damage in 131I-resistant DTC cells. Mechanistically, knockdown of circ_NEK6 suppressed 131I resistance in DTC by upregulating the inhibitory effect of miR-370-3p on the expression of myosin heavy chain 9 (MYH9...
Source: Technology in Cancer Research and Treatment - March 24, 2021 Category: Cancer & Oncology Authors: Fukun Chen Shuting Yin Zhiping Feng Chao Liu Juan Lv Yuanjiao Chen Ruoxia Shen Jiaping Wang Zhiyong Deng Source Type: research

< em > PVT1 < /em > Expression Is a Predictor for Poor Survival of Prostate Cancer Patients
Technol Cancer Res Treat. 2021 Jan-Dec;20:1533033820971610. doi: 10.1177/1533033820971610.ABSTRACTOBJECTIVE: Dysregulation of long noncoding RNA is associated with a variety of cancers and LncRNA has anticancer or carcinogenic activities. PVT1, as a long noncoding RNA, plays an important role in the development of cancer.METHODS: We use R to download and analyze the data in TCGA database. ROC curve is generated to evaluate the significance of PVT1 expression for the diagnosis of prostate cancer. Chi-square test is used to test correlation between PVT1 expression and clinical pathological features. Survival curve and univar...
Source: Technology in Cancer Research and Treatment - March 23, 2021 Category: Cancer & Oncology Authors: Jianhua Liu Yanqing Li Qiqi Zhang Chaoxiang Lv Mingwei Wang Yan Jiao Chunxi Wang Source Type: research

Study on Relationships of Tumor Status and Gene Polymorphism With Blood Concentration of MTX and Toxicities in 63 Pediatric Mature B Cell Lymphoma in Chinese Population
This study investigated the relationships of tumor status (stage, renal involvement, bone marrow status, bulky disease, liver function), tumor gene polymorphism, and methotrexate (MTX) dosage (stratified by treatment group) with blood MTX levels and adverse reactions (ADR).METHODS: We retrospectively reviewed 63 mature B cell lymphoma patients who were treated in our center. Genotyping of the MTHFR 677 and SLCO1B1 genes was carried out, and the relationships between tumor status, polymorphism of the genes, MTX level, and ADR were analyzed.RESULTS: Altogether, 63 children were included. The mean blood MTX concentration was ...
Source: Technology in Cancer Research and Treatment - March 23, 2021 Category: Cancer & Oncology Authors: Shuang Huang Lin Jin Jing Yang Long Yan Duan Meng Zhang Ju Chun Zhou Hong Yong Zhang Source Type: research

Hypoxia-Inducible Factor 2a Expression Is Positively Correlated With Gleason Score in Prostate Cancer
Technol Cancer Res Treat. 2021 Jan-Dec;20:1533033821990010. doi: 10.1177/1533033821990010.ABSTRACTBACKGROUND: One of the main factors in response to hypoxia in the tumor microenvironment is the hypoxia-inducible factor (HIF) pathway. Although its role in other solid tumors, particularly renal cell carcinoma, has been sufficiently elucidated, it remains elusive in prostate cancer. The aim of the present study was to investigate the expression of main proteins involved in this pathway and determine the correlation of the results with clinicopathological outcomes of patients with prostate cancer.METHODS: The immunohistochemic...
Source: Technology in Cancer Research and Treatment - March 23, 2021 Category: Cancer & Oncology Authors: Dimitrios Pavlakis Spyridon Kampantais Konstantinos Gkagkalidis Victoras Gourvas Dimitrios Memmos Aikaterini Tsionga Georgios Dimitriadis Ioannis Vakalopoulos Source Type: research

Relationship Between Serum Inflammatory Factor Levels and Differentiated Thyroid Carcinoma
CONCLUSIONS: Inflammation plays an important role in TA and DTC progression. Preoperative IL-27 and CRP levels help to differentially diagnose DTC. Moreover, IL-27 assists in distinguishing FTC from PTC, and NLR+PLR is important for the differential diagnosis of PTC.PMID:33752541 | DOI:10.1177/1533033821990055 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - March 23, 2021 Category: Cancer & Oncology Authors: Xue Zhang Su Li Jinhui Wang Fubao Liu Yong Zhao Source Type: research

MIR-301b-3p Promotes Lung Adenocarcinoma Cell Proliferation, Migration and Invasion by Targeting DLC1
CONCLUSIONS: Collectively, miR-301b-3p was identified to actively function on LUAD malignant progression by suppressing DLC1 expression. This discovery provides a novel therapeutic strategy for LUAD patients, which helps improve the survival of patients.PMID:33754907 | DOI:10.1177/1533033821990036 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - March 23, 2021 Category: Cancer & Oncology Authors: Haitao Liu Xingjie Ma Niu Niu Junjie Zhao Chao Lu Fan Yang Weibo Qi Source Type: research

Identification of Prognostic RBPs in Osteosarcoma
In conclusion, DDX24, DDX21, WARS and IGF2BP2 might play key role in osteosarcoma, which could be therapuetic targets for osteosarcoma treatment.PMID:33754909 | DOI:10.1177/15330338211004918 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - March 23, 2021 Category: Cancer & Oncology Authors: Bei Li Long Fang Baolong Wang Zengkun Yang Tingbao Zhao Source Type: research

< em > PVT1 < /em > Expression Is a Predictor for Poor Survival of Prostate Cancer Patients
Technol Cancer Res Treat. 2021 Jan-Dec;20:1533033820971610. doi: 10.1177/1533033820971610.ABSTRACTOBJECTIVE: Dysregulation of long noncoding RNA is associated with a variety of cancers and LncRNA has anticancer or carcinogenic activities. PVT1, as a long noncoding RNA, plays an important role in the development of cancer.METHODS: We use R to download and analyze the data in TCGA database. ROC curve is generated to evaluate the significance of PVT1 expression for the diagnosis of prostate cancer. Chi-square test is used to test correlation between PVT1 expression and clinical pathological features. Survival curve and univar...
Source: Technology in Cancer Research and Treatment - March 23, 2021 Category: Cancer & Oncology Authors: Jianhua Liu Yanqing Li Qiqi Zhang Chaoxiang Lv Mingwei Wang Yan Jiao Chunxi Wang Source Type: research

Study on Relationships of Tumor Status and Gene Polymorphism With Blood Concentration of MTX and Toxicities in 63 Pediatric Mature B Cell Lymphoma in Chinese Population
This study investigated the relationships of tumor status (stage, renal involvement, bone marrow status, bulky disease, liver function), tumor gene polymorphism, and methotrexate (MTX) dosage (stratified by treatment group) with blood MTX levels and adverse reactions (ADR).METHODS: We retrospectively reviewed 63 mature B cell lymphoma patients who were treated in our center. Genotyping of the MTHFR 677 and SLCO1B1 genes was carried out, and the relationships between tumor status, polymorphism of the genes, MTX level, and ADR were analyzed.RESULTS: Altogether, 63 children were included. The mean blood MTX concentration was ...
Source: Technology in Cancer Research and Treatment - March 23, 2021 Category: Cancer & Oncology Authors: Shuang Huang Lin Jin Jing Yang Long Yan Duan Meng Zhang Ju Chun Zhou Hong Yong Zhang Source Type: research

Hypoxia-Inducible Factor 2a Expression Is Positively Correlated With Gleason Score in Prostate Cancer
Technol Cancer Res Treat. 2021 Jan-Dec;20:1533033821990010. doi: 10.1177/1533033821990010.ABSTRACTBACKGROUND: One of the main factors in response to hypoxia in the tumor microenvironment is the hypoxia-inducible factor (HIF) pathway. Although its role in other solid tumors, particularly renal cell carcinoma, has been sufficiently elucidated, it remains elusive in prostate cancer. The aim of the present study was to investigate the expression of main proteins involved in this pathway and determine the correlation of the results with clinicopathological outcomes of patients with prostate cancer.METHODS: The immunohistochemic...
Source: Technology in Cancer Research and Treatment - March 23, 2021 Category: Cancer & Oncology Authors: Dimitrios Pavlakis Spyridon Kampantais Konstantinos Gkagkalidis Victoras Gourvas Dimitrios Memmos Aikaterini Tsionga Georgios Dimitriadis Ioannis Vakalopoulos Source Type: research

Relationship Between Serum Inflammatory Factor Levels and Differentiated Thyroid Carcinoma
CONCLUSIONS: Inflammation plays an important role in TA and DTC progression. Preoperative IL-27 and CRP levels help to differentially diagnose DTC. Moreover, IL-27 assists in distinguishing FTC from PTC, and NLR+PLR is important for the differential diagnosis of PTC.PMID:33752541 | DOI:10.1177/1533033821990055 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - March 23, 2021 Category: Cancer & Oncology Authors: Xue Zhang Su Li Jinhui Wang Fubao Liu Yong Zhao Source Type: research

MIR-301b-3p Promotes Lung Adenocarcinoma Cell Proliferation, Migration and Invasion by Targeting DLC1
CONCLUSIONS: Collectively, miR-301b-3p was identified to actively function on LUAD malignant progression by suppressing DLC1 expression. This discovery provides a novel therapeutic strategy for LUAD patients, which helps improve the survival of patients.PMID:33754907 | DOI:10.1177/1533033821990036 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - March 23, 2021 Category: Cancer & Oncology Authors: Haitao Liu Xingjie Ma Niu Niu Junjie Zhao Chao Lu Fan Yang Weibo Qi Source Type: research

Identification of Prognostic RBPs in Osteosarcoma
In conclusion, DDX24, DDX21, WARS and IGF2BP2 might play key role in osteosarcoma, which could be therapuetic targets for osteosarcoma treatment.PMID:33754909 | DOI:10.1177/15330338211004918 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - March 23, 2021 Category: Cancer & Oncology Authors: Bei Li Long Fang Baolong Wang Zengkun Yang Tingbao Zhao Source Type: research