Clinical outcome of robot-assisted residual mass resection in metastatic nonseminomatous germ cell tumor
ConclusionRA-RMR is an appropriate treatment option in selected patients, potentially providing excellent cure rates with minimal morbidity. Long-term outcome data are needed to further support this strategy and determine inclusion and exclusion criteria. (Source: World Journal of Urology)
Source: World Journal of Urology - September 21, 2020 Category: Urology & Nephrology Source Type: research

Comparison of intrapelvic pressures during flexible ureteroscopy, mini-percutaneous nephrolithotomy, standard percutaneous nephrolithotomy, and endoscopic combined intrarenal surgery in a kidney model
ConclusionWe recorded for the first time IPP values according to different endourological techniques and configurations. IPP never exceed 50 cmH2O irrespectively of the assessed technique/setup. The factors reducing IPP were a low irrigation pressure (40  cmH2O), the use of a UAS or a working sheath appropriate to the diameter of the endoscope, as well as the occupation of the working channel in the case of f-URS. (Source: World Journal of Urology)
Source: World Journal of Urology - September 21, 2020 Category: Urology & Nephrology Source Type: research

The BUSCOPAN study: a randomized-controlled non-inferiority trial of a continuous butylscopolamine infusion versus placebo in patients with a renal colic not responding to oral non-steroidal anti-inflammatory drugs
ConclusionPlacebo is non-inferior to continuous IV butylscopolamine for pain relief in patients with renal colic. Based on this study and previous evidence, there is no role for continuous butylscopolamine IV in the treatment of renal colic.Trial NL7819 (Source: World Journal of Urology)
Source: World Journal of Urology - September 19, 2020 Category: Urology & Nephrology Source Type: research

Risk factors for infection complications after transrectal ultrasound-guided transperineal prostate biopsy
ConclusionsPatients with diabetes and history of urinary retention were more likely to have infection complications after transperineal prostate biopsy. (Source: World Journal of Urology)
Source: World Journal of Urology - September 19, 2020 Category: Urology & Nephrology Source Type: research

The effect of cannabis on prostate-specific antigen level among men in the United States: results from the National Health and Nutrition Examination Survey
(Source: World Journal of Urology)
Source: World Journal of Urology - September 19, 2020 Category: Urology & Nephrology Source Type: research

A multi-institutional critical assessment of dorsal onlay urethroplasty for post-radiation urethral stenosis
ConclusionDorsal onlay buccal mucosa graft urethroplasty is a safe and feasible technique in patients with post-radiation posterior urethral stenosis. This non-transecting approach may confer low rates of de-novo SUI. Further research is needed to compare this technique with excisional urethroplasty. (Source: World Journal of Urology)
Source: World Journal of Urology - September 17, 2020 Category: Urology & Nephrology Source Type: research

Systematic review of the endoscopic enucleation of the prostate learning curve
ConclusionAlthough EEP is considered challenging, it shows a steep learning curve with a plateau after 30 –50 cases. Proper criteria are critical for accurate assessment of the learning curve. The Trifecta and Pentafecta criteria are currently the most appropriate method to evaluate EEP learning. (Source: World Journal of Urology)
Source: World Journal of Urology - September 17, 2020 Category: Urology & Nephrology Source Type: research

Integration of exome sequencing and metabolic evaluation for the diagnosis of children with urolithiasis
ConclusionExome sequencing in a cohort of 105 pediatric patients with urolithiasis yielded a genetic diagnosis in 36% of cases and the molecular diagnostic yield varies substantially across different metabolic abnormalities. (Source: World Journal of Urology)
Source: World Journal of Urology - September 16, 2020 Category: Urology & Nephrology Source Type: research

Evaluation, diagnosis and surveillance of renal masses in the setting of VHL disease
AbstractThis brief report focuses on the evaluation and diagnosis of clinically localized renal masses in children and adults with Von Hippel –Lindau (VHL) disease. Counseling considerations pertinent to the urologists, medical oncologists, and multidisciplinary teams involved in the care of these patients are addressed. As practice patterns regarding the evaluation and management of VHL tumors can vary considerably, this report aims to provide guidance on some of the controversies associated with the diagnostic evaluation and initial management of localized renal masses in VHL patients. (Source: World Journal of Urology)
Source: World Journal of Urology - September 16, 2020 Category: Urology & Nephrology Source Type: research

Reasons to believe in vaporization: a review of the benefits of photo-selective and transurethral vaporization
ConclusionProstate vaporization for the treatment of BPE appears to be an efficient and safer alternative to TURP. Vaporization techniques, particularly Greenlight PVP, should be offered to most men, especially those under anticoagulation therapy, as well as patients at risk of bleeding complications. (Source: World Journal of Urology)
Source: World Journal of Urology - September 15, 2020 Category: Urology & Nephrology Source Type: research

Percutaneous nephrolithotomy in patients with spinal cord injury: should all these patients be automatically assigned a Guy ’s stone score of 4?
ConclusionPatients with SCI should not be automatically assigned GSS 4. Stone-free rate is related to stone burden in these patients, although they do show a higher complication rate and a longer hospital stay than non-neurological patients. (Source: World Journal of Urology)
Source: World Journal of Urology - September 15, 2020 Category: Urology & Nephrology Source Type: research

Correction to: Preoperative urine nitrite versus urine culture for predicting postoperative fever following flexible ureteroscopic lithotripsy: a propensity score matching analysis
Table  3 shows the comparisons of baseline characteristics after applying PSM. (Source: World Journal of Urology)
Source: World Journal of Urology - September 15, 2020 Category: Urology & Nephrology Source Type: research

Ejaculation-sparing thulium laser enucleation of the prostate (ES-ThuLEP): outcomes on a large cohort
ConclusionES-ThuLEP effectively preserved ejaculation in over two thirds of the patients without compromising micturition improvement or erectile function. ES-ThuLEP could be a valid treatment option for BPH in young and sexually active men. (Source: World Journal of Urology)
Source: World Journal of Urology - September 14, 2020 Category: Urology & Nephrology Source Type: research

A prospective comparative study of routine versus deferred pelvic drain placement after radical prostatectomy: impact on complications and opioid use
ConclusionThere was no difference in adverse events, complications, symptomatic collections, or opioid use with deferral of routine drain placement after RP. Experienced surgeons may safely defer drain placement in the majority of robot-assisted RP cases. (Source: World Journal of Urology)
Source: World Journal of Urology - September 14, 2020 Category: Urology & Nephrology Source Type: research

A prospective, multi-center, open-label, single-arm phase 2b study of autologous adult live cultured buccal epithelial cells (AALBEC) in the treatment of bulbar urethral stricture
ConclusionSignificant improvement was seen in the AUA symptom score and uroflowmetry parameters and no patients required surgery during 24  weeks post-treatment. It can be concluded that AALBEC is a safe and effective treatment for bulbar urethral stricture of 1 − 4 cm length to improve the quality of life and the physiological function of urethra. (Source: World Journal of Urology)
Source: World Journal of Urology - September 14, 2020 Category: Urology & Nephrology Source Type: research

Online interest in surgical treatment for benign prostatic hyperplasia using Google trends
ConclusionsA shift in online interest towards minimally invasive surgical therapies for benign prostatic hyperplasia was demonstrated in the US and worldwide and parallels clinical practice patterns, such as HoLEP and Urolift surgical volumes in Indiana and Australia, respectively. Google Trends can be used in real-time to gauge online interest for surgical procedures and help guide physician –patient counseling. (Source: World Journal of Urology)
Source: World Journal of Urology - September 14, 2020 Category: Urology & Nephrology Source Type: research

Enhanced recovery after surgery (ERAS) following radical cystectomy: is it worth implementing for all patients?
ConclusionERAS protocol implementation following radical cystectomy showed significant improvements in GIT recovery, nevertheless, it did not result in a decrease in LOS or readmission rates. Low-risk patients appeared to derive more benefit from ERAS protocol implementation than high-risk patients. (Source: World Journal of Urology)
Source: World Journal of Urology - September 11, 2020 Category: Urology & Nephrology Source Type: research

Combined radiotherapy and immunotherapy in urothelial bladder cancer: harnessing the full potential of the anti-tumor immune response
ConclusionRT has the potential to synergize with immunotherapy to improve oncological outcomes in patient with localized or metastatic MIBC. Clinical trials results are eagerly awaited. (Source: World Journal of Urology)
Source: World Journal of Urology - September 11, 2020 Category: Urology & Nephrology Source Type: research

Prospects and Challenges of Artificial Intelligence and Computer Science for the Future of Urology
(Source: World Journal of Urology)
Source: World Journal of Urology - September 10, 2020 Category: Urology & Nephrology Source Type: research

Real-world comparative effectiveness of shockwave lithotripsy versus ureterorenoscopy for the treatment of urinary stones
AbstractPurposeTo identify clinical and non-clinical predictors of treatment failure and perioperative complications following ureterorenoscopy versus shockwave lithotripsy.MethodsThe New York State Department of Health Statewide Planning and Research Cooperative System (SPARCS) database was used to identify 226,331 patients who underwent index ureteroscopy or shockwave lithotripsy for renal stones from 2000 to 2016. Propensity-matched generalized linear-mixed modeling was utilized to compare failure and complication rates between the two procedure groups.Results219,383 individuals meeting inclusion criteria who underwent ...
Source: World Journal of Urology - September 9, 2020 Category: Urology & Nephrology Source Type: research

Preliminary assessment of patient and physician satisfaction with the use of teleconsultation in urology during the COVID-19 pandemic
ConclusionIntroduced rapidly during the COVID-19 lockdown, urology teleconsultation attained a high level of satisfaction among both patients and physicians. A major change in telemedicine use is foreseen in the post COVID-19 era. (Source: World Journal of Urology)
Source: World Journal of Urology - September 9, 2020 Category: Urology & Nephrology Source Type: research

Scoping review: hotspots for COVID-19 urological research: what is being published and from where?
ConclusionThis review has outlined available original research relevant to COVID-19 and urology from the international community. This summary may serve as a guide for future research priorities in this area. (Source: World Journal of Urology)
Source: World Journal of Urology - September 9, 2020 Category: Urology & Nephrology Source Type: research

Trends in the pharmacological treatment of benign prostatic hyperplasia in the UK from 1998 to 2016: a population-based cohort study
ConclusionThe prescription rate of BPH medications increased substantially between 1998 and 2016 in the UK, with the greatest relative increase observed with combination therapy. Adherence to BPH medications was low in this population-based study. (Source: World Journal of Urology)
Source: World Journal of Urology - September 9, 2020 Category: Urology & Nephrology Source Type: research

Informative value of histological assessment of tissue acquired during aquablation of the prostate
ConclusionHistological significance of the tissue obtained by aquablation of the prostate is very limited. Costs and effort of the histological examination must, therefore, be weighed critically against the limited informative value. (Source: World Journal of Urology)
Source: World Journal of Urology - September 9, 2020 Category: Urology & Nephrology Source Type: research

A right colon pouch with a novel efferent channel concept: long-term results of the Turin pouch
ConclusionIn relation to similar systems, the TP seems to offer comparatively good functional results but EC and stoma complications were lower than other pouch variants in literature. (Source: World Journal of Urology)
Source: World Journal of Urology - September 8, 2020 Category: Urology & Nephrology Source Type: research

Visceral Obesity in living kidney Asian donors – long term impact of renal function after donor nephrectomy
(Source: World Journal of Urology)
Source: World Journal of Urology - September 8, 2020 Category: Urology & Nephrology Source Type: research

Clinical trials in urological oncology: COVID-19 and the potential need for a new perspective
AbstractThe COVID-19 pandemic has led to the suspension, termination or alteration of thousands of clinical trials as the health emergency escalated globally. Whilst the rapid suspension of certain clinical trials was necessary to ensure the safety of high-risk or vulnerable trial participants as well as healthcare workers, the long-term ramifications that this delay will have on the field of urologic oncology is unknown. The COVID-19 pandemic has highlighted the need to plan for and implement new strategies to advance our understanding of unmet areas of need in urologic oncology. The COVID-19 pandemic has led to the suspe...
Source: World Journal of Urology - September 4, 2020 Category: Urology & Nephrology Source Type: research

Imbalance of nerve growth factor metabolism in aging women with overactive bladder syndrome
ConclusionNGF proteolysis imbalance can be clinically meaningful in OAB related to aging, rendering it as a potential therapeutic target. However, other age-related factors such as insulin resistance and renal function may contribute to the relationship between NGF and aging-related OAB phenotype. (Source: World Journal of Urology)
Source: World Journal of Urology - September 1, 2020 Category: Urology & Nephrology Source Type: research

Comment on “Bladder infusion versus standard catheter removal for trial of void: a systematic review and meta-analysis”
(Source: World Journal of Urology)
Source: World Journal of Urology - September 1, 2020 Category: Urology & Nephrology Source Type: research

Differences in survival and impact of adjuvant chemotherapy in patients with variant histology of tumors of the renal pelvis
The objective of this study was to assess the survival of the predominant variant histologies of tumors of the renal pelvis (RPT) after surgical intervention, and to examine the influence of AC on the OS of the different variant histologies.MethodsWe identified 21,318 patients with RPT undergoing surgical intervention using the National Cancer Database for the period 2004 –2015. We employed multivariable Cox proportional hazards regression models and Kaplan–Meier curves to evaluate the OS according to variant histology. Separate multivariable Cox regression models were used to assess the specific effect of AC o...
Source: World Journal of Urology - August 13, 2020 Category: Urology & Nephrology Source Type: research

Complications of ureteroscopy: a complete overview
ConclusionUreteroscopy seems to be associated with more complications than currently reported.  The present overview may help urologists to prevent, recognize and solve complications of ureteroscopy. It may also stimulate colleagues to perform prospective studies using standardized systems for classifying complications. These are warranted to compare results among different studies, to condu ct meta-analyses, to inform health care workers and to counsel patients correctly about possible risks of ureteroscopy. (Source: World Journal of Urology)
Source: World Journal of Urology - August 13, 2020 Category: Urology & Nephrology Source Type: research

Dependence of laser-induced tissue ablation on optical fiber movements for laser prostatectomy
ConclusionsOptimal ablation efficiency occurred at a TS of 2  mm/s and a RS of 1.0 rad/s with a thin coagulation of around 1.0 mm and no or minimal carbonization. Further studies will validate the current findings with prostate tissue and high-power levels for laser prostatectomy. (Source: World Journal of Urology)
Source: World Journal of Urology - August 13, 2020 Category: Urology & Nephrology Source Type: research

Extirpative renal surgery volume in training: different roads to the (same?) destination
AbstractPurposeTo describe the overall extirpative renal surgery (ERS) training volume reported by PU and PS.MethodsCase log data from the Accreditation Council for Graduate Medical Education (ACGME) was examined from 2013 –2016 for surgery residents (Sres), urology residents (Ures), pediatric surgery fellows (PSfel) and pediatric urology fellows (PUfel). Case log information for all levels of participation over all case categories that could potentially offer ERS volume were recorded. Volume was estimated using the mean number of included cases during residency and fellowship and the sum was used to estimate total t...
Source: World Journal of Urology - August 13, 2020 Category: Urology & Nephrology Source Type: research

Development and internal validation of a nomogram to predict perioperative complications after flexible ureteroscopy for renal stones in overnight ureteral catheterization cases
ConclusionsWe developed a predictive model for perioperative complications of patients with overnight catheterization after fURS for renal stones. This model could select patients who were at a low risk of complications. (Source: World Journal of Urology)
Source: World Journal of Urology - August 13, 2020 Category: Urology & Nephrology Source Type: research

Is regenerative medicine the future of urology?
(Source: World Journal of Urology)
Source: World Journal of Urology - August 13, 2020 Category: Urology & Nephrology Source Type: research

Correction to: Tissue engineering of the urethra: where are we in 2019?
Conclusion in the original publication [1] is incorrect. We have removed this sentence and the correct version can be found in this Erratum. (Source: World Journal of Urology)
Source: World Journal of Urology - August 13, 2020 Category: Urology & Nephrology Source Type: research

Late complications of robot-assisted radical cystectomy with totally intracorporeal urinary diversion
AbstractIntroduction and objectivesTo evaluate late complications in a large cohort of patients undergoing robot-assisted radical cystectomy (RARC) with totally intracorporeal urinary diversion (ICUD).Materials and methodsWe prospectively enrolled patients who underwent RARC and ICUD between August 2012 and June 2019. We excluded patients with Ejection fraction  
Source: World Journal of Urology - August 3, 2020 Category: Urology & Nephrology Source Type: research

PSA-based machine learning model improves prostate cancer risk stratification in a screening population
ConclusionsDevelopment of a dense neural network model  improved the diagnostic accuracy in screening for prostate cancer. These results demonstrate an additional utility of machine learning methods in prostate cancer risk stratification when using biochemical parameters. (Source: World Journal of Urology)
Source: World Journal of Urology - August 3, 2020 Category: Urology & Nephrology Source Type: research

Athermal versus ultrasonic nerve-sparing laparoscopic radical prostatectomy: a comparison of functional and oncological outcomes
ConclusionsThe use of an ultrasonic device compared to athermal dissection during NSLRP does not affect long-term potency, nor continence and early biochemical recurrence. (Source: World Journal of Urology)
Source: World Journal of Urology - August 1, 2020 Category: Urology & Nephrology Source Type: research

Opiates prescribed for acute renal colic are associated with prolonged use
ConclusionsPatients prescribed new opiates for acute nephrolithiasis and those with an existing opioid prescription are likely to require refills before resolution of the stone episode. Larger stones that require surgery (not spontaneous passage) also increase the risk. Timely treatment of these patients and initial treatment with non-narcotics may reduce the risk of prolonged opiate use. (Source: World Journal of Urology)
Source: World Journal of Urology - August 1, 2020 Category: Urology & Nephrology Source Type: research

Robotic-assisted bladder neck procedures in children with neurogenic bladder
ConclusionsRobotic-assisted procedures of the bladder neck are safe, feasible, follow the same steps and principles as those of open surgery and produce equivalent continence rates. Robotic-assisted techniques can be adapted to a variety of bladder neck procedures and safely expanded to selected patients with the previous open abdominal surgery. (Source: World Journal of Urology)
Source: World Journal of Urology - July 15, 2020 Category: Urology & Nephrology Source Type: research

PD-L1 expression and pattern of immune cells in pre-treatment specimens are associated with disease-free survival for HR-NMIBC undergoing BCG treatment
ConclusionDespite an association between PD-L1 expression and BCG failure in HR-NMIBC, the PD-L1  + status was not a prognostic factor in the response of BCG. Moreover, we confirmed the key role played by the IC within the microenvironment in BCG treatment. These findings highlighted the rationale to combine BCG and PD-L1/PD-1 antibodies in early bladder cancer. (Source: World Journal of Urology)
Source: World Journal of Urology - July 14, 2020 Category: Urology & Nephrology Source Type: research

The natural course of urinalysis after urinary diversion
ConclusionA positive urinalysis is a common finding after urinary diversion. Hydronephrosis is a serious risk factor with respect to infection-related complications. The simple fact of a positive urinalysis does not warrant antimicrobial treatment. (Source: World Journal of Urology)
Source: World Journal of Urology - July 13, 2020 Category: Urology & Nephrology Source Type: research

Positive Ki-67 and PD-L1 expression in post-neoadjuvant chemotherapy muscle-invasive bladder cancer is associated with shorter overall survival: a retrospective study
ConclusionPositive Ki-67 and PD-L1 expression in post-NAC radical cystectomy samples was associated with inferior OS and absence of tumor downstaging. IHC on Ki-67 and PD-L1 would help to select patients for adjuvant therapy in post-NAC muscle-invasive bladder cancer. (Source: World Journal of Urology)
Source: World Journal of Urology - July 12, 2020 Category: Urology & Nephrology Source Type: research

Achieving the “trifecta” with open versus minimally invasive partial nephrectomy
ConclusionAfter correction for confounding variables, OPN and LPN were more likely than RPN to achieve the trifecta, which appeared to be due primarily to loss of renal function. No difference was observed between OPN and LPN. Analyses were limited by the lack of nephrometry score. (Source: World Journal of Urology)
Source: World Journal of Urology - July 12, 2020 Category: Urology & Nephrology Source Type: research

A comparison of flow rate curve shape and video-urodynamic findings in women with lower urinary tract symptoms: can flow rate curve shape predict female bladder outflow obstruction or detrusor underactivity?
ConclusionFlow rate curve patterns can be suggestive of urodynamic diagnoses. Women without a prolonged void and bell-shaped traces had normal voiding urodynamics in 76% of cases, and the majority could be managed without invasive investigations. Patients with fluctuating and intermittent flow rate curves demonstrate a spectrum of urodynamic diagnoses with a third of cases having obstruction and a third of cases having detrusor underactivity. Plateau flow rate curve patterns are associated with urethral obstruction. (Source: World Journal of Urology)
Source: World Journal of Urology - July 11, 2020 Category: Urology & Nephrology Source Type: research

Stoma complications and quality of life in patients with Indiana pouch versus appendico/neo-appendico-umbilicostomy urinary diversions
ConclusionUrinary diversion using the Indiana pouch and right colon pouch with appendico/neo-appendico-umbilicostomy are all associated with high rates of continence and patient satisfaction. When compared to IP, AU and NAU patients had higher rates of high-grade diversion-related complications and NAU patients had a higher stoma complications with lower 90-day continence rate. (Source: World Journal of Urology)
Source: World Journal of Urology - July 10, 2020 Category: Urology & Nephrology Source Type: research

Critical analysis of quality of life and cost-effectiveness of enhanced recovery after surgery (ERAS) for patient ’s undergoing urologic oncology surgery: a systematic review
ConclusionWhile limited studies are published on the subject, ERAS implementation for radical cystectomy and laparoscopic nephrectomy improved patient-reported QOL during early phases of recovery. For radical cystectomy, there was a decreased or neutral overall financial cost associated with ERAS. Further studies assessing QOL and cost-effectiveness over the entire global period of care in a variety of urologic oncology surgeries are warranted. (Source: World Journal of Urology)
Source: World Journal of Urology - July 9, 2020 Category: Urology & Nephrology Source Type: research

Oncocytoma: risk of promoting unnecessary surgery
(Source: World Journal of Urology)
Source: World Journal of Urology - July 9, 2020 Category: Urology & Nephrology Source Type: research

Clinical recommendations in the management of advanced prostate cancer: International Gastrointestinal, Liver and Uro-oncology (IGILUC 2019) experts
ConclusionThis review offers a thorough understanding of APC practice and offers insight on the various opinions shared amongst experts in the field that can serve as guidance regionally and deepens our understanding of disease management globally. (Source: World Journal of Urology)
Source: World Journal of Urology - July 8, 2020 Category: Urology & Nephrology Source Type: research