Age-related urologic problems in the complex urologic patient
ConclusionsMost evidence regarding complex urogenital abnormalities comes from the pediatric population. Evidence regarding common, age-related urological issues is generally from the ‘normal’ adult population. As patients with complex congenital urological conditions live longer, more data will become available to assess the long-term benefits of intervention. (Source: World Journal of Urology)
Source: World Journal of Urology - February 15, 2020 Category: Urology & Nephrology Source Type: research

Impact of time to second transurethral resection on oncological outcomes of patients with high-grade T1 bladder cancer treated with intravesical Bacillus Calmette –Guerin
ConclusionsThis is the first study testing the role of time to Re-TUR in a homogeneous population of patients with high-grade T1 BC who received complete BCG treatment. The study challenged the concept the sooner the Re-TUR the better, since time to Re-TUR did not significantly affect oncological outcomes. (Source: World Journal of Urology)
Source: World Journal of Urology - February 15, 2020 Category: Urology & Nephrology Source Type: research

Screening of characteristic biomolecules related to bladder cancer based on construction of ceRNA regulation network
ConclusionsIn bladder cancer tumor samples, samples down-regulated by LINC01198, PPTRD-AS1, has-miR-216a, SEMA3D, EPHA5, and DCLK1 had a good overall survival prognosis, indicating that these several characteristic target molecules were found to be high-risk factors for bladder cancer tumors. (Source: World Journal of Urology)
Source: World Journal of Urology - February 14, 2020 Category: Urology & Nephrology Source Type: research

Inflammation is a target of medical treatment for lower urinary tract symptoms associated with benign prostatic hyperplasia
ConclusionsPersistent PIS plays a central role in both the development and progression of LUTS/BPH. In men with LUTS/BPH who have a high chance of harbouring persistent PIS, HESr will not only improve LUTS, but also reduce (underlying) inflammation. Well-designed clinical studies, with a good level of evidence, are required to better evaluate the impact of BPH/LUTS medical therapies on persistent PIS. (Source: World Journal of Urology)
Source: World Journal of Urology - February 14, 2020 Category: Urology & Nephrology Source Type: research

Outcomes of artificial urinary sphincter in female with neurological stress urinary incontinence: a long-term follow-up
ConclusionAlthough all methods are imperfect at best, AUS remain toward our experience a good way to achieve long-term continence in female patients suffering from neurological SUI with preserved manual dexterity. (Source: World Journal of Urology)
Source: World Journal of Urology - February 12, 2020 Category: Urology & Nephrology Source Type: research

Value-based care for the treatment and evaluation of benign prostatic hyperplasia: an analysis of a metropolitan service area claims database
AbstractPurposeWith an aging population, cost containment and improved outcomes will be crucial for a sustainable healthcare ecosystem. Current data demonstrate great variation in payments for procedures and diagnostic workup of benign prostatic hyperplasia (BPH). To help determine the best financial value in BPH care, we sought to analyze the major drivers of total payments in BPH.Materials and methodsCommercial and Medicare claims from the Truven Health Analytics Markestscan® database for the Austin, Texas Metropolitan Service Area from 2012 to 2014 were queried for encounters with diagnosis and procedural codes rela...
Source: World Journal of Urology - February 11, 2020 Category: Urology & Nephrology Source Type: research

Design, implementation, and evaluation of a novel curriculum to teach transurethral resection of the prostate (TURP): a 3-year experience of urology simulation bootcamp course
AbstractObjectivesTo present the three-year experience of the multi-component TURP module at Urology Simulation Bootcamp Course (USBC) and demonstrate trainee ’s competence progression and satisfaction.MethodsDuring the USBC, a 4-h TURP module was developed and consisted of (a) familiarisation and assembly of resectoscope instrument, (b) didactic lecture on TURP operative techniques and postoperative complications, (c) learning hands-on resection on validated simulators [Samed, GmBH, Dresden, Germany; TURP Mentor ™, Simbionix, Israel], and (d) practicing clot evacuation using the Ellik bladder Evacuator. Traine...
Source: World Journal of Urology - February 10, 2020 Category: Urology & Nephrology Source Type: research

Determinants of self-reported functional status (EPIC-26) in prostate cancer patients prior to treatment
ConclusionsPretherapeutic sr-FS varies by clinical patient characteristics and age as well as by socioeconomic status. The findings point out the benefit of collecting and considering socioeconomic information in addition to clinical and demographic patient characteristics for treatment decision-making and fair comparisons between health-care providers. (Source: World Journal of Urology)
Source: World Journal of Urology - February 10, 2020 Category: Urology & Nephrology Source Type: research

Laser enucleation of the prostate versus transurethral resection of the prostate: perioperative outcomes from the ACS NSQIP database
ConclusionReal-life data from a large national database confirmed that LEP is a safe and reproducible procedure to treat benign prostatic obstruction. Compared to TURP, LEP was associated with a lower rate of infectious complications and a shorter LOS at the expense of an increased operative time. (Source: World Journal of Urology)
Source: World Journal of Urology - February 8, 2020 Category: Urology & Nephrology Source Type: research

Functional and perioperative outcomes in elderly men after robotic-assisted radical prostatectomy for prostate cancer
ConclusionOur results suggest that RARP is feasible in elderly patients. Nevertheless, elderly patients in the  ≥ 70-year-old group had significantly inferior postoperative continence rates compared to patients aged 66–69 years. Such information is valuable when counselling men during preoperative RARP planning to ensure that they have realistic postoperative expectations. (Source: World Journal of Urology)
Source: World Journal of Urology - February 7, 2020 Category: Urology & Nephrology Source Type: research

Challenges facing the urologist in low- and middle-income countries
ConclusionsLMICs lack enough training opportunities and urologists to care for their population. There is disconnect between the needs identified by local and visiting urologists. International collaborations should target broader interventions in LMICs to address local priorities such as diagnostic studies, support staff and financial support. (Source: World Journal of Urology)
Source: World Journal of Urology - February 7, 2020 Category: Urology & Nephrology Source Type: research

Local delivery of vasodilators for the reduction of ureteral contractions: limited but promising
(Source: World Journal of Urology)
Source: World Journal of Urology - February 7, 2020 Category: Urology & Nephrology Source Type: research

The era of the digital natives is approaching: Insights into online peer-to-peer support for persons affected by prostate cancer
(Source: World Journal of Urology)
Source: World Journal of Urology - February 7, 2020 Category: Urology & Nephrology Source Type: research

TUR-P phantom for resident surgical training: food-based design as a human mimicking model of the prostate
This study would like to develop a novel model similar to human prostate in terms of its texture profile, sensation upon resection, and anatomical hallmarks for resident transurethral resection of the prostate (TUR-P) training.MethodsTen phantom designs were proposed, using broadly available ingredients and a homemade protocol. Three steps of evaluation and development were done: objective measurement measuring texture profile (e.g. hardness, elasticity, cohesiveness/consistency, and adhesiveness/stickiness) using TA-XT2i Texture Analyzer (Llyod Instruments, Ametek Inc) to compare the designs with human prostate, finding t...
Source: World Journal of Urology - February 4, 2020 Category: Urology & Nephrology Source Type: research

A modified technique for intralesional injection of collagenase Clostridium histolyticum for Peyronie ’s disease results in reduced procedural morbidity using a standardized hematoma classification rubric
ConclusionA modified injection technique results in reduced procedural morbidity. A hematoma classification system provides clarity and standardization to the assessment of safety in PD treatment. Further clinical studies with control arms are required to verify these findings. (Source: World Journal of Urology)
Source: World Journal of Urology - January 31, 2020 Category: Urology & Nephrology Source Type: research

Reply letter to: Comments to & quot;Systematic review and cumulative analysis of the managements for proximal impacted ureteral stones & quot; by Gao ZY
(Source: World Journal of Urology)
Source: World Journal of Urology - January 30, 2020 Category: Urology & Nephrology Source Type: research

Higher expression of phosphodiesterase type 5 in the anterior fibromuscular stroma of the human prostate
ConclusionsWe found higher PDE5 expression in the AFMS compared with other prostatic regions, which suggested that the AFMS is a target region of PDE5 inhibitors in the prostate. (Source: World Journal of Urology)
Source: World Journal of Urology - January 29, 2020 Category: Urology & Nephrology Source Type: research

Substantial radiation dose reduction with consistent image quality using a novel low-dose stone composition protocol
AbstractPurposeTo assess a novel low-dose CT-protocol, combining a 150  kV spectral filtration unenhanced protocol (Sn150 kVp) and a stone-targeted dual-energy CT (DECT) in patients with urolithiasis.Methods232 (151 male, 49  ± 16.4 years) patients with urolithiasis received a low-dose non-contrast enhanced CT (NCCT) for suspected urinary stones either on a third-generation dual-source CT system (DSCT) using Sn150 kVp (n = 116, group 1), or on a second-generation DSCT (n = 116 group 2) using single energy (SE) 120 kVp. For group 1, a subsequent dual-...
Source: World Journal of Urology - January 28, 2020 Category: Urology & Nephrology Source Type: research

How much energy do we need to ablate 1 mm 3 of stone during Ho:YAG laser lithotripsy? An in vitro study
ConclusionThis in vitro study shows for the first time a volumetric evaluation of Ho:YAG efficiency by the ablation volume per pulse on human stone samples, according to various pulse energies. The REs for COM, UA and Cys should be considered in clinical practice. (Source: World Journal of Urology)
Source: World Journal of Urology - January 27, 2020 Category: Urology & Nephrology Source Type: research

Paravertebral block for percutaneous nephrolithotomy: a prospective, randomized, double-blind placebo-controlled study
ConclusionThe results of this randomized, double-blind, placebo-controlled trial suggest that PVB should be considered an effective strategy to reduce opioid requirement and improve pain control for patients undergoing PCNL. (Source: World Journal of Urology)
Source: World Journal of Urology - January 25, 2020 Category: Urology & Nephrology Source Type: research

The impact of extended pelvic lymph node dissection on the risk of hospital readmission within 180  days after robot assisted radical prostatectomy
ConclusionsOver the long term after RARP for PCA, the risk of hospital readmission is associated with ePLND. In patients who underwent RARP and ePLND, 4.4% of them had a readmission, compared to RARP alone, in which only 0.8% of cases had a readmission. When ePLND is planned for staging pelvic lymph nodes, patients should be informed of the increased risk of hospital readmission. (Source: World Journal of Urology)
Source: World Journal of Urology - January 24, 2020 Category: Urology & Nephrology Source Type: research

Chronic inflammation promotes proliferation in the prostatic stroma in rats with experimental autoimmune prostatitis: study for a novel method of inducing benign prostatic hyperplasia in a rat model
ConclusionChronic inflammation can induce BPH in rats via EAP model method. When performing drug experiments on the stroma compartments of BPH, the use of the EAP model is a recommendation of the authors based on this study. (Source: World Journal of Urology)
Source: World Journal of Urology - January 21, 2020 Category: Urology & Nephrology Source Type: research

The relationship between glucose homeostasis status and prostate size in aging Chinese males with benign prostatic hyperplasia
AbstractPurposeIncreasing evidence shows that many metabolic factors are involved in the progression of benign prostatic hyperplasia (BPH). We aimed to assess the relationship between the status of glucose homeostasis and prostate size in aging Chinese males undergoing transurethral resection of the prostate (TURP) for BPH.MethodsA total of 1006 medical records of BPH patients undergoing TURP were reviewed. Prostate size was measured by transrectal ultrasound. Annual total prostate (TP) and transitional zone (TZ) growth rates were calculated. According to the American Diabetes Association criteria, the patients were catego...
Source: World Journal of Urology - January 21, 2020 Category: Urology & Nephrology Source Type: research

Slingshot homolog-1 expression is a poor prognostic factor of pT1 bladder urothelial carcinoma after transurethral resection
In this study, 359 (57.53%) specimens were detected with SSH-1 expression. SSH-1 positivity was significantly associated with higher pathological grade (p = 0.020), lymphovascular invasion (p = 0.006), tumor recurrence (p 
Source: World Journal of Urology - January 21, 2020 Category: Urology & Nephrology Source Type: research

RE: The evaluation of early predictive factors for urosepsis in patients with negative preoperative urine culture following mini-percutaneous nephrolithotomy
(Source: World Journal of Urology)
Source: World Journal of Urology - January 21, 2020 Category: Urology & Nephrology Source Type: research

A treatment strategy to help select patients who may not need secondary intervention to remove symptomatic ureteral stones after previous stenting
This study aimed at evaluating whether removal of the ureteral stent the day before scheduled secondary intervention facilitates spontaneous ureteral stone passage and thus can spare the pre-stented patient this surgery.MethodsRetrospective analysis of a single-centre consecutive series of 216 patients after previous stenting due to a symptomatic ureteral stone from 01/2013 to 01/2018. Indwelling stents were removed under local anaesthesia. Patients were told to filter their urine overnight. Multivariate analysis was performed to assess predictive factors for spontaneous stone passage.Results34% (74/216) of patients had sp...
Source: World Journal of Urology - January 20, 2020 Category: Urology & Nephrology Source Type: research

Leydig-cell tumour of the testis: retrospective analysis of clinical and therapeutic features in 204 cases
ConclusionLCT is rare, with a relative frequency (relative to GCT) of 1:23. Malignancy is found in 2.5%. LCT and GCT share a number of clinical features, e.g. bilaterality, history of undescended testis, and presenting age. TSS is safe in benign LCT. Surgery is the treatment of choice in malignant LCT. (Source: World Journal of Urology)
Source: World Journal of Urology - January 20, 2020 Category: Urology & Nephrology Source Type: research

Survival of contemporary patients with non-metastatic urachal vs. non-urachal adenocarcinoma of the urinary bladder
AbstractPurposeTo test the effect of tumor location (urachal vs. non-urachal) on cancer-specific mortality (CSM) in patients with adenocarcinoma of the urinary bladder (ADKUB).Materials and methodsWithin the Surveillance, Epidemiology, and End Results registry (2004 –2016), we identified patients with non-metastatic (≤ T4N0M0) ADKUB. Stratification was made according to tumor location: urachal vs. non-urachal ADKUB. Kaplan–Meier plots and multivariable Cox regression models were fitted before and after 1:3 propensity score (PS) matching and separate Cox r egression models were refitted before and after inver...
Source: World Journal of Urology - January 20, 2020 Category: Urology & Nephrology Source Type: research

Correction to: Mechanical and functional validation of a perfused, robot-assisted partial nephrectomy simulation platform using a combination of 3D printing and hydrogel casting
The Eqs.  1, 2 and 3 come under the section “Kidney cortex testing” as per the original manuscript, but they have been incorrectly moved and separated into different sections in the original publication of the article. (Source: World Journal of Urology)
Source: World Journal of Urology - January 20, 2020 Category: Urology & Nephrology Source Type: research

Clinical perspectives from ongoing trials in oligometastatic or oligorecurrent prostate cancer: an analysis of clinical trials registries
AbstractPurposeThanks to the introduction of more sensitive/specific imaging and minimally invasive treatment techniques, the oligometastatic state in prostate cancer (PCa) has attracted the interest of the uro-oncological community. We aim to identify and analyze trials across five registries to gain insights into the directions this field is moving.MethodsA systematic review of trials on oligometastatic PCa registered on ClinicalTrials.gov, ANZCTR, ISRCTN, Netherlands and UMIN Clinical Trials Registries was performed using the following keywords: ‘prostate cancer’ and ‘oligo’. Data were extracted ...
Source: World Journal of Urology - January 18, 2020 Category: Urology & Nephrology Source Type: research

The LACE  + index as a predictor of 90-day urologic surgery outcomes
ConclusionThese results suggest that LACE  + may be a suitable prediction model for important patient outcomes after urologic surgery. (Source: World Journal of Urology)
Source: World Journal of Urology - January 17, 2020 Category: Urology & Nephrology Source Type: research

Assessment of the effects of autologous muscle-derived cell injections on urethral sphincter morphometry using 3D/4D ultrasound
AbstractPurposeThe primary objective was to evaluate the effect of autologous muscle-derived cell (AMDC) injections on the urethral sphincter morphometry compared to placebo injections. Secondary aims were to explore the reduction of stress incontinence episode frequency (IEF) and factors associated with the efficacy of AMDC.MethodsThis prospective randomized-controlled study compared the urethral sphincter volumes of participants who had received either an intra-sphincteric injection of 4  cc AMDC in injection media or 4 cc placebo solution, using a transperineal 3D/4D ultrasound at baseline and at 12 month...
Source: World Journal of Urology - January 14, 2020 Category: Urology & Nephrology Source Type: research

Perioperative antithrombotic (antiplatelet and anticoagulant) therapy in urological practice: a critical assessment and summary of the clinical practice guidelines
ConclusionThe perioperative management of antithrombotic therapy in urological patients is potentially challenging but inconsistent CPG of varying quality may create uncertainty as to best practices to minimize thromboembolic and bleeding risk. (Source: World Journal of Urology)
Source: World Journal of Urology - January 14, 2020 Category: Urology & Nephrology Source Type: research

Two-stage repair of proximal hypospadias with moderate to severe chordee using inner preputial skin graft: prospective evaluation of functional and cosmetic outcomes
ConclusionInner preputial graft use in proximal hypospadias with moderate to severe chordee seems to have a good technical outcome and functionally mimic the normal urethral function and could be considered an ideal option for substitution urethroplasty. (Source: World Journal of Urology)
Source: World Journal of Urology - January 14, 2020 Category: Urology & Nephrology Source Type: research

Traumatic spinal cord injury confers bladder cancer risk to patients managed without permanent urinary catheterization: lessons from a comparison of clinical data with the national database
AbstractPurposeLife expectancy for people with traumatic spinal cord injury (SCI) is increasing due to advances in treatment methods and in neuro-urology. Thus, developing urinary bladder cancer (UBC) is gaining importance.MethodsSingle-centre retrospective evaluation of consecutive in- and out-patient data with spinal cord injury between January 1st, 1998 and December 31st, 2018 was carried out and data were compared with UBC data of the German population from the German Centre for Cancer Registry Data at Robert Koch Institute.ResultsA total of 37 (4 female, 33 male) out of 7004 patients with SCI were diagnosed with histo...
Source: World Journal of Urology - January 13, 2020 Category: Urology & Nephrology Source Type: research

Long short-term memory artificial neural network model for prediction of prostate cancer survival outcomes according to initial treatment strategy: development of an online decision-making support system
ConclusionThe LSTM ANN model may provide individualized survival outcomes of PCa according to initial treatment strategy. Our online decision-making support system can be utilized by patients and health-care providers to determine the optimal initial treatment modality and to guide survival predictions. (Source: World Journal of Urology)
Source: World Journal of Urology - January 10, 2020 Category: Urology & Nephrology Source Type: research

Application of artificial neural networks for automated analysis of cystoscopic images: a review of the current status and future prospects
ConclusionAI-aided cystoscopy has the potential to outperform urologists at recognizing and classifying bladder lesions. To ensure their real-life implementation, however, these algorithms require external validation to generalize their results across other data sets. (Source: World Journal of Urology)
Source: World Journal of Urology - January 10, 2020 Category: Urology & Nephrology Source Type: research

Letter to the Editor regarding the article “Comparison of intra- and postoperative analgesia and pain perception in robot-assisted vs. open radical prostatectomy”
(Source: World Journal of Urology)
Source: World Journal of Urology - January 10, 2020 Category: Urology & Nephrology Source Type: research

Epidemiology of urological infections: a global burden
ConclusionAs frequent infectious diseases, UTIs create clinical and economic burdens on healthcare systems, and they also affect quality of life determinants. (Source: World Journal of Urology)
Source: World Journal of Urology - January 10, 2020 Category: Urology & Nephrology Source Type: research

The effect of focus size and intensity on stone fragmentation in SWL on a piezoelectric lithotripter
AbstractPurposeWe aim to analyze the efficacy of different focus sizes and the influence of pulse pressure (intensity) during shock wave lithotripsy (SWL) in terms of stone fragmentation.MethodsCombination of three focal sizes (F1  = 2 mm,F2  = 4 mm,F3  = 8 mm) and 11 output pressure settings (intensity 10–20) of a piezoelectric lithotripter (Wolf PiezoLith 3000) were tested on artificial stones (n = 99). The stones were placed within a 2 mm mesh cage. The needed number of shockwaves (SW) to first visible crack, 50% and 100% stone disintegrat...
Source: World Journal of Urology - January 10, 2020 Category: Urology & Nephrology Source Type: research

Letter to the Editor regarding the article “Radical prostatectomy after previous transurethral resection of the prostate: oncological, surgical and functional outcomes—a meta-analysis”
(Source: World Journal of Urology)
Source: World Journal of Urology - January 9, 2020 Category: Urology & Nephrology Source Type: research

Antibiotic prophylaxis in TURP: a prospective analysis concerning antibiotic stewardship and a potential reduction of antibiotic use in TURP
(Source: World Journal of Urology)
Source: World Journal of Urology - January 9, 2020 Category: Urology & Nephrology Source Type: research

Urine routine tests: a guideline-neglected, but indispensable investment in stone-removing endourological procedures
(Source: World Journal of Urology)
Source: World Journal of Urology - January 8, 2020 Category: Urology & Nephrology Source Type: research

Predictive factors of stone-free rate and complications in patients undergoing minimally invasive percutaneous nephrolithotomy under local infiltration anesthesia
AbstractPurposeTo evaluate predictive factors affecting the stone-free rates (SFR) and complications of minimally invasive percutaneous nephrolithotomy (MPCNL) under local infiltration anesthesia (LIA)MethodsA retrospective analysis was conducted on 976 consecutive patients who underwent MPCNL under LIA from January 2015 to June 2018. Postoperative complications were classified according to modified Clavien classification system. Univariate and multivariate logistic regression analyses were used to determine factors affecting SFR and complications.ResultsThe pain was acceptable with postoperative visual analog scale (VAS) ...
Source: World Journal of Urology - January 7, 2020 Category: Urology & Nephrology Source Type: research

The 365  μm holmium laser in flexible ureteroscopic lithotripsy: prospect and risk coexist?
(Source: World Journal of Urology)
Source: World Journal of Urology - January 7, 2020 Category: Urology & Nephrology Source Type: research

External validation of Cormio nomogram for predicting all prostate cancers and clinically significant prostate cancers
ConclusionWe confirmed that the Cormio nomogram can be used to predict the risk of PCa in patients at increased risk. Implementation of the nomogram in clinical practice will better define its role in the patient ’s counselling before prostate biopsy. (Source: World Journal of Urology)
Source: World Journal of Urology - January 6, 2020 Category: Urology & Nephrology Source Type: research

Simultaneous whole-body PET/MRI with integrated multiparametric MRI for primary staging of high-risk prostate cancer
ConclusionMpMRI is the primary modality for T-staging in hrPC as PET underestimated T-stage in direct comparison to final pathology. In this selected study, cohort MRI shows no inferiority compared to wbPET/MRI considering N-staging. (Source: World Journal of Urology)
Source: World Journal of Urology - January 6, 2020 Category: Urology & Nephrology Source Type: research

Prognostic significance of pre- and post-treatment PD-L1 expression in patients with primary high-grade non-muscle-invasive bladder cancer treated with BCG immunotherapy
ConclusionPre-treatment PD-L1 expression was associated with unfavorable pathological features in primary high-grade NMIBC and its expression level after BCG immunotherapy was significantly decreased in patients with refractory recurrence. PD-L1 expression did not have prognostic value for PFS or RFS; therefore, further research is necessary to identify novel biomarkers for prediction of disease outcomes in high-grade NMIBC. (Source: World Journal of Urology)
Source: World Journal of Urology - January 3, 2020 Category: Urology & Nephrology Source Type: research

3D printing technology in percutaneous nephrolithotomy: babyhood but will be promising
(Source: World Journal of Urology)
Source: World Journal of Urology - January 3, 2020 Category: Urology & Nephrology Source Type: research

Navigating systemic therapy for metastatic castration-na ïve prostate cancer
ConclusionThe introduction of potent systemic therapy earlier in the mCNPC disease course has resulted in dramatic improvements in clinical outcomes for patients. As the management of mCNPC continues to evolve, the future remains promising, with the expectation of ongoing improvements to patient outcomes and quality of life. (Source: World Journal of Urology)
Source: World Journal of Urology - January 2, 2020 Category: Urology & Nephrology Source Type: research