Safety of pembrolizumab as adjuvant therapy in a pooled analysis of phase 3 clinical trials of melanoma, non –small cell lung cancer, and renal cell carcinoma
The safety profile of adjuvant pembrolizumab was evaluated in a pooled analysis of 4 phase 3 clinical trials. (Source: European Journal of Cancer)
Source: European Journal of Cancer - May 30, 2024 Category: Cancer & Oncology Authors: Jason J. Luke, Georgina V. Long, Caroline Robert, Matteo S. Carlino, Toni K. Choueiri, Naomi B. Haas, Mary O ’Brien, Luis Paz-Ares, Solange Peters, Thomas Powles, Melanie A. Leiby, Jianxin Lin, Yujie Zhao, Clemens Krepler, Rodolfo F. Perini, M. Catherin Tags: Original Research Source Type: research
Exosome-derived circUPF2 enhances resistance to targeted therapy by redeploying ferroptosis sensitivity in hepatocellular carcinoma
Advanced hepatocellular carcinoma (HCC) can be treated with sorafenib, which is the primary choice for targeted therapy. Nevertheless, the effectiveness of sorafenib is greatly restricted due to resistance. Re... (Source: Journal of Nanobiotechnology)
Source: Journal of Nanobiotechnology - May 30, 2024 Category: Nanotechnology Authors: Feng-Lin Dong, Zong-Zhen Xu, Ying-Qiao Wang, Tao Li, Xin Wang and Jie Li Tags: Research Source Type: research
β-Sitosterol alleviates the malignant phenotype of hepatocellular carcinoma cells via inhibiting GSK3B expression
AbstractTo explore the effects of β-Sitosterol upon hepatocellular carcinoma cell proliferation, apoptosis, migration, invasion, and epithelial–mesenchymal transition (EMT), and to investigate the underlying mechanism using network pharmacology. Human hepatocellular carcinoma cell lines (Huh-7 and HCCLM3) were expose to gradient concentrations of β-Sitosterol (5 μg/mL, 10 μg/mL, and 20 μg/mL). Cell viability and proliferation were assessed using MTT, CCK-8, colony formation, and EdU assays.Flow cytometry was employed to evaluate cell cycle and apoptosis. Scratch and Transwell assays were performed, respectively, ...
Source: Human Cell - May 30, 2024 Category: Cytology Source Type: research
Cancers, Vol. 16, Pages 2065: Immune and Microbial Signatures Associated with PD-1 Blockade Sensitivity in a Preclinical Model for HPV+ Oropharyngeal Cancer
remera
The United States is suffering from an epidemic associated with high-risk strains of the Human Papillomavirus (HPV) predominantly responsible for the development of head and neck squamous cell carcinoma (HNSCC). Treatment with immune checkpoint inhibitors targeting programmed death 1 (PD-1) or its ligand PD-L1 has shown poor efficacy in HNSCC patients, observing only a 20–30% response. Therefore, biological marker identification associated with PD-1 blockade response is important to improve prognosis and define novel therapeutics for HNSCC patients. Therapy response was associated with increased fr...
Source: Cancers - May 30, 2024 Category: Cancer & Oncology Authors: Jennifer D íaz-Rivera Michael A. Rodr íguez-Rivera Natalie M. Mel éndez-Vázquez Filipa Godoy-Vitorino Stephanie M. Dorta-Estremera Tags: Article Source Type: research
The machine learning ‐based model for lateral lymph node metastasis of thyroid medullary carcinoma improved the prediction ability of occult metastasis
ConclusionsWe developed a LLNM prediction model for MTC using machine learning based on clinical baseline characteristics and TI-RADS. Our model can predict occult LLNM for cN0 −1a patients more accurately, then benefit the decision of prophylactic LND. (Source: Cancer Medicine)
Source: Cancer Medicine - May 29, 2024 Category: Cancer & Oncology Authors: Xiwei Zhang,
Xiaohui Zhao,
Lichao Jin,
Qianqian Guo,
Minghui Wei,
Zhengjiang Li,
Lijuan Niu,
Zhiqiang Liu,
Changming An Tags: RESEARCH ARTICLE Source Type: research
Immunoglobulin G4-related Autoimmune Pancreatitis and Hypopituitarism Following Immune Checkpoint Inhibitor Therapy: A Case Report
Intern Med. 2024 May 30. doi: 10.2169/internalmedicine.3591-24. Online ahead of print.ABSTRACTA 70-year-old man underwent nephrectomy for renal cell carcinoma followed by 3 cycles of pembrolizumab as adjuvant chemotherapy. Three months later, he complained of appetite loss. He was diagnosed with secondary adrenal insufficiency and pancreatic tumor. Amylase and immunoglobulin G (IgG) 4 levels were normal. The differential diagnosis poses challenges in distinguishing pancreatic cancer, renal cell carcinoma metastasis, and autoimmune pancreatitis, necessitating tumor resection surgery. A histological examination revealed IgG4...
Source: Internal Medicine - May 29, 2024 Category: Internal Medicine Authors: Saori Inoue Yukiko Tsunoda Kana Yamamoto Hideki Okamoto Source Type: research
A Case of Chronic Hepatitis B in which HBs Antigen Seroclearance was Induced by Pegpegylated-interferon α-2a after Hepatocellular Carcinoma Treatment with Nucleos(t)ide Analogues: A Five-year Follow-up
Intern Med. 2024 May 30. doi: 10.2169/internalmedicine.3643-24. Online ahead of print.ABSTRACTWe herein report a 40-year-old Japanese man with chronic hepatitis B genotype C (viral load 6.7 LC/mL) who developed hepatocellular carcinoma (HCC) despite achieving undetectable hepatitis B virus (HBV) DNA levels with nucleos (t) ide analog (NA) treatment (entecavir). Notably, his hepatitis B surface antigen (HBsAg) level remained elevated at 388.4 IU/mL. Given the continued risk of carcinogenesis associated with HBsAg positivity, we initiated pegylated interferon (PEG-IFN) therapy one month after HCC surgery. Following three per...
Source: Internal Medicine - May 29, 2024 Category: Internal Medicine Authors: Shima Mimura Masafumi Ono Koji Fujita Kei Takuma Mai Nakahara Kyoko Oura Tomoko Tadokoro Joji Tani Asahiro Morishita Seiko Kagawa Keiichi Okano Takashi Himoto Tsutomu Masaki Source Type: research
Case of Pulmonary Tumor Embolism due to Oropharyngeal Carcinoma Diagnosed by a Transbronchial Lung Biopsy
Intern Med. 2024 May 30. doi: 10.2169/internalmedicine.3596-24. Online ahead of print.ABSTRACTPulmonary tumor embolisms (PTEs) are primarily caused by adenocarcinoma. However, only a few cases of oropharyngeal carcinoma have been reported. We herein report a 47-year-old man who presented with a fever, cough, and dyspnea 6 months after treatment for stage II oropharyngeal carcinoma. Chest computed tomography revealed centrilobular granular and nodular shadows and subpleural consolidation. A transbronchial lung biopsy revealed a mass of squamous tumor cells forming emboli in the small vessels, resulting in the diagnosis of P...
Source: Internal Medicine - May 29, 2024 Category: Internal Medicine Authors: Moriyasu Anai Shohei Hamada Takayuki Jodai Hiroko Okabayashi Koichi Saruwatari Yusuke Tomita Hidenori Ichiyasu Takuro Sakagami Source Type: research
Ectopic Adrenocorticotropic Hormone Syndrome due to Pancreatic Neuroendocrine Carcinoma: A Case Report
Intern Med. 2024 May 30. doi: 10.2169/internalmedicine.3672-24. Online ahead of print.ABSTRACTA 55-year-old woman presented to her primary care physician with facial and lower leg edema. After being referred to our hospital because of hypothyroidism and hypokalemia on blood tests, she also had elevated adrenocorticotropic hormone (ACTH) and cortisol levels, but a dexamethasone suppression test showed no cortisol suppression. Ectopic ACTH syndrome due to pancreatic neuroendocrine carcinoma (PNEC) was suspected. endoscopic ultrasound-guided fine-needle aspiration was performed, and a histopathological examination of the obta...
Source: Internal Medicine - May 29, 2024 Category: Internal Medicine Authors: Aya Kawanishi Ryuzo Deguchi Ayano Ito Takashi Ueda Kota Tsuruya Yoshitaka Arase Yoshihiro Shirataki Toshiki Kodama Masashi Morimachi Tatehiro Kagawa Source Type: research
Theranostic Potential of Bacteriophages against Oral Squamous Cell Carcinoma
Curr Gene Ther. 2024 May 28. doi: 10.2174/0115665232305905240521081553. Online ahead of print.ABSTRACTOral Squamous Cell Carcinoma (OSCC) is a widespread and challenging disease that accounts for 94% of cancers of the oral cavity worldwide. Bacteriophages (phages) have shown promise as a potential theranostic agent for the treatment of OSCC. It may offer advantages in overcoming the challenges of conventional methods. Modern high-throughput pyrosequencing techniques confirm the presence of specific bacterial strains associated with OSCC. Bio-panning and filamentous phages facilitate visualization of the peptide on surfaces...
Source: Current Gene Therapy - May 29, 2024 Category: Genetics & Stem Cells Authors: Maheswaran Easwaran Sivagnanavelmurugan Madasamy Baskar Venkidasamy Source Type: research
Genetically redirected HBV-specific T cells target HBsAg-positive hepatocytes and primary lesions in HBV-associated HCC
CONCLUSIONS: SCG101 T-cell therapy showed encouraging efficacy and safety in pre-clinical models and in a patient with primary HBV-HCC and concomitant chronic hepatitis B with the capability to eliminate HBsAg+ cells and achieve sustained tumor control after single dosing.PMID:38808361 | DOI:10.3350/cmh.2024.0058 (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - May 29, 2024 Category: Gastroenterology Authors: Xueshuai Wan Karin Wisskirchen Tao Jin Lu Yang Xiaorui Wang Xiang'an Wu Fang Liu Yu Wu Christy Ma Yong Pang Qi Li Ke Zhang Ulrike Protzer Shunda Du Source Type: research
Routine Surveillance of Upper Urinary Tract Imaging for Diagnosing Upper Urinary Tract Urothelial Cancer Recurrence in Patients with Nonmuscle Invasive Bladder Cancer
CONCLUSION: Most patients experiencing upper urinary tract urothelial cancer recurrence were diagnosed by routine surveillance imaging, suggesting its clinical importance, especially for patients with nonmuscle invasive bladder cancer accompanied by a tumor size of ≥30 mm and carcinoma in situ.PMID:38807901 | PMC:PMC11132829 | DOI:10.1155/2024/5894288 (Source: Advances in Urology)
Source: Advances in Urology - May 29, 2024 Category: Urology & Nephrology Authors: Nobutaka Nishimura Makito Miyake Tatsuki Miyamoto Takuto Shimizu Tomomi Fujii Yosuke Morizawa Shunta Hori Daisuke Gotoh Yasushi Nakai Kazumasa Torimoto Nobumichi Tanaka Kiyohide Fujimoto Source Type: research
Temozolomide alleviates breast carcinoma via the inhibition of EGFR/ERK/ MMP-1 pathway with induction of apoptotic events
CONCLUSIONS: The occurrence of mammary carcinoma has been significantly decreased by activation of apoptotic pathway and abrogation of cellular propagation that allowable for developing a suitable mechanistic pathway of temozolomide in order to facilitate chemotherapeutic approach.PMID:38808816 | PMC:PMC11126306 | DOI:10.1590/acb391624 (Source: Acta Cirurgica Brasileira)
Source: Acta Cirurgica Brasileira - May 29, 2024 Category: Surgery Authors: Weijun Zhu Fengjun Zhang Maoyun Wang Shuai Meng Fang Ren Source Type: research
Advances in combined neuroendocrine carcinoma of lung cancer
This study focuses specifically on combined pulmonary carcinomas with a neuroendocrine component. In this comprehensive review article, the authors provide an overview of combined lung cancers and present two pathological images to visually depict these distinctive subtypes.PMID:38807858 | PMC:PMC11130380 | DOI:10.3389/pore.2024.1611693 (Source: Pathology Oncology Research)
Source: Pathology Oncology Research - May 29, 2024 Category: Pathology Authors: Zesen Han Fujun Yang Fang Wang Huayu Zheng Xiujian Chen Hongyu Meng Fenglei Li Source Type: research
Diagnostic Value of Dermoscopic Structures in Predicting Superficial Basal Cell Carcinoma in the Skin of Color
CONCLUSION: Dermoscopy exhibited superior specificity compared to the naked eye in differentiating superficial BCC from other BCC types. Notably, the spoke-wheel structure demonstrated the most robust correlation with superficial BCC.PMID:38808321 | PMC:PMC11132197 | DOI:10.4103/abr.abr_315_23 (Source: Biomed Res)
Source: Biomed Res - May 29, 2024 Category: Research Authors: Maryam Khalili Sare Mirahmadi Simin Shamsimeymandi Shahriar Dabiri Rezvan Amiri Mohammad Rezaei Zadeh Rukerd Mahin Aflatoonian Source Type: research
