Histological Inflammation in Human Ureter either Healthy or Fitted with Double-Pigtail Stent or a Thin 0.3  F Suture Thread: A Preliminary Study.
Conclusion: Although the study was limited by the small number of patients, it confirmed that the double-pigtail stent induced ureteral inflammation in all cases and the thin 0.3 F suture thread caused less ureteral inflammation than the double-pigtail stent. The concept of material reduction within the urinary tract seems necessary in order to decrease mucosal irritation. The JFil® or the MiniJFil® thread could meet this requirement. PMID: 32695158 [PubMed] (Source: Advances in Urology)
Source: Advances in Urology - July 23, 2020 Category: Urology & Nephrology Tags: Adv Urol Source Type: research

Removal of the Tumor Thrombus from the Right Atrium without Extracorporeal Circulation: Emphasis on the Displacement of the Tumor Apex.
Conclusion: Our work represents the initial experience in the liver transplantation technique for thrombectomy in distinct and well-selected patients with atrial tumor thrombi. The effectiveness of this approach needs further study. The video presentation of our research took place in March 2019 at the 34th Annual EAU Congress in Barcelona. PMID: 32612649 [PubMed] (Source: Advances in Urology)
Source: Advances in Urology - July 3, 2020 Category: Urology & Nephrology Tags: Adv Urol Source Type: research

Analysis of Learning Curve in Robot-Assisted Radical Prostatectomy Performed by a Surgeon.
In conclusion, there are several types of learning curves for RARP. First, the shallowest learning curve was observed for the OT. Regarding the analysis of "advanced learning curve," demonstrating the improvement of OT and blood loss is considered insufficient. Therefore, additional oncological and functional results that require a longer period of investigation are required. PMID: 32547617 [PubMed] (Source: Advances in Urology)
Source: Advances in Urology - June 19, 2020 Category: Urology & Nephrology Tags: Adv Urol Source Type: research

Efficacy of Tamsulosin plus Tadalafil versus Tamsulosin as Medical Expulsive Therapy for Lower Ureteric Stones: A Randomized Controlled Trial.
Conclusion: Tamsulosin plus Tadalafil is more effective than tamsulosin with early passage of stone and decreased number of colic episodes and emergency visits without significant side effects for lower ureteric calculi of 5 mm to 10 mm. PMID: 32411212 [PubMed] (Source: Advances in Urology)
Source: Advances in Urology - May 17, 2020 Category: Urology & Nephrology Tags: Adv Urol Source Type: research

Critical Assessment of Single-Use Ureteroscopes in an In Vivo Porcine Model.
Authors: Ceballos B, Nottingham CU, Bechis SK, Sur RL, Matlaga BR, Krambeck AE Abstract Methods: A female pig was placed under general anesthesia and positioned supine, and retrograde access to the renal collecting system was obtained. The LithoVue (Boston Scientific) and Uscope (Pusen Medical) were evaluated by three experienced surgeons, and each surgeon started with a new scope. The following parameters were compared between each ureteroscope: time for navigation to upper and lower pole calyces with and without implements (1.9 F basket, 200 μm laser fiber, and 365 μm laser fiber for up...
Source: Advances in Urology - May 13, 2020 Category: Urology & Nephrology Tags: Adv Urol Source Type: research

Prospective Multicenter Open-Label One-Arm Trial Investigating a Pumpkin Seed, Isoflavonoids, and Cranberry Mix in Lower Urinary Tract Symptoms/Benign Prostatic Hyperplasia: A Pilot Study.
Authors: Nemr E, El Helou E, Mjaess G, Semaan A, Chebel JA Abstract Phytotherapy for lower urinary tract symptoms (LUTSs) due to benign prostate hyperplasia (BPH) is progressively demanded by patients and trusted by physicians. The aim was to assess the efficacy of a mix of pumpkin seed extract, soy germ isoflavonoids, and cranberry (Novex®) in the management of mild to moderate LUTS in BPH patients. Male patients aged ≥40 years, who had had mild to moderate LUTS for>6 months at screening, with no previous therapy or who are still symptomatic despite current use of alpha-blockers, were recruited. Exclusio...
Source: Advances in Urology - March 28, 2020 Category: Urology & Nephrology Tags: Adv Urol Source Type: research

Microbiome within Primary Tumor Tissue from Renal Cell Carcinoma May Be Associated with PD-L1 Expression of the Venous Tumor Thrombus.
Conclusion: Renal tumors have more diverse microbiomes than normal adjacent tissue. Identification of resident oral microbiome profiles in clear-cell renal cancer with tumor thrombus provides a potential biomarker for thrombus response to PD-L1 inhibition. PMID: 32148479 [PubMed] (Source: Advances in Urology)
Source: Advances in Urology - March 11, 2020 Category: Urology & Nephrology Tags: Adv Urol Source Type: research

Traumatic Bladder Ruptures: A Ten-Year Review at a Level 1 Trauma Center.
Authors: Barnard J, Overholt T, Hajiran A, Crigger C, Jessop M, Knight J, Morley C Abstract Bladder rupture occurs in only 1.6% of blunt abdominopelvic trauma cases. Although rare, bladder rupture can result in significant morbidity if undiagnosed or inappropriately managed. AUA Urotrauma Guidelines suggest that urethral catheter drainage is a standard of care for both extraperitoneal and intraperitoneal bladder rupture regardless of the need for surgical repair. However, no specific guidance is given regarding the length of catheterization. The present study seeks to summarize contemporary management of bladder tr...
Source: Advances in Urology - January 11, 2020 Category: Urology & Nephrology Tags: Adv Urol Source Type: research

Nephrolithiasis and Polycystic Ovary Syndrome: A Case-Control Study Evaluating Testosterone and Urinary Stone Metabolic Panels.
Conclusions: Compared to healthy stone formers, PCOS patients did not demonstrate significant differences in 24-hour urine and stone composition values. Elevated free testosterone in PCOS patients has a significant association with higher urinary citrate and sodium values: findings that in and of themselves do not confirm the hypothesized increased risk of stone formation. This patient cohort may provide deeper insight into the interplay between androgens and stone formation; however, further study is needed to fully characterize the possible relationship between PCOS and stone formation. PMID: 31772573 [PubMed] (Sourc...
Source: Advances in Urology - November 28, 2019 Category: Urology & Nephrology Tags: Adv Urol Source Type: research

Histoprotective Effect of Essential Oil from Citrus aurantifolia in Testosterone-Induced Benign Prostatic Hyperplasia Rat.
Authors: Acheampong DO, Barffour IK, Boye A, Asiamah EA, Armah FA, Adokoh CK, Oluyemi JF, Adrah B, Opoku R, Adakudugu E Abstract Background: Benign prostatic hyperplasia (BPH) is a common urological disorder reported among ageing men. Objective: The study assessed histoprotective effect of lime essential oil (LEO) in a rat model of testosterone-induced benign prostatic hyperplasia (BPH) and evaluated its ability to reverse testosterone-mediated changes in the testis, kidney, and liver. Materials and Methods: Adult Sprague Dawley (aged 12 weeks, 240-390 g) male rats were intramuscularly injecte...
Source: Advances in Urology - November 1, 2019 Category: Urology & Nephrology Tags: Adv Urol Source Type: research

Treatment of Priapism Secondary to Drugs for Erectile Dysfunction.
This study was done with the objective to describe the management of priapism secondary to erectile dysfunction drugs in a cohort of men. Records of emergencies and adverse events were reviewed by two researchers to identify patients diagnosed with erectile dysfunction who received oral or intracavernosal drugs for their illness and presented priapism. Sociodemographic data, clinical background, and information on the duration, management, and evolution of the priapism were extracted. Priapism incidence, percentage of improvement by type of treatment subgroups, and frequency of complications were estimated. 698 patients we...
Source: Advances in Urology - September 21, 2019 Category: Urology & Nephrology Tags: Adv Urol Source Type: research

Initial Evaluation of Computer-Assisted Radiologic Assessment for Renal Mass Edge Detection as an Indication of Tumor Roughness to Predict Renal Cancer Subtypes.
Authors: Rajendran R, Iffrig K, Pruthi DK, Wheeler A, Neuman B, Kaushik D, Mansour AM, Panetta K, Agaian S, Liss MA Abstract Objective: To develop software to assess the potential aggressiveness of an incidentally detected renal mass using images. Methods: Thirty randomly selected patients who underwent nephrectomy for renal cell carcinoma (RCC) had their images independently reviewed by engineers. Tumor "Roughness" was based on image algorithm of tumor topographic features visualized on computed tomography (CT) scans. Univariant and multivariant statistical analyses are utilized for analysis. Res...
Source: Advances in Urology - June 7, 2019 Category: Urology & Nephrology Tags: Adv Urol Source Type: research

Adult Neurogenic Lower Urinary Tract Dysfunction and Intermittent Catheterisation in a Community Setting: Risk Factors Model for Urinary Tract Infections.
Authors: Kennelly M, Thiruchelvam N, Averbeck MA, Konstatinidis C, Chartier-Kastler E, Trøjgaard P, Vaabengaard R, Krassioukov A, Jakobsen BP Abstract A risk factor model for urinary tract infections in patients with adult neurogenic lower urinary tract dysfunction performing clean intermittent catheterisation was developed; it consists of four domains, namely, (1) general (systemic) conditions in the patient, (2) individual urinary tract conditions in the patient, (3) routine aspects related to the patient, and (4) factors related to intermittent catheters per se. The conceptual model primarily concerns pat...
Source: Advances in Urology - May 10, 2019 Category: Urology & Nephrology Tags: Adv Urol Source Type: research

Prevalence of Age-Associated Testosterone Deficiency Syndrome in Indian Population.
Authors: Yadav GK, Pahwa M, Singh M, Tyagi V, Chadha S Abstract Testosterone deficiency syndrome (TDS) is a gradual age-related phenomenon that occurs in a large proportion of the aging male population. This current prospective study was done with the objective to estimate the prevalence of age-associated TDS in India and its clinical profile. A total of 800 male patients aged ≥40 year were approached to participate in the study. A brief history and focused examination was done. Based on our exclusion criteria, 55 patients were excluded. Androgen deficiency in aging male (ADAM) questionnaire was administe...
Source: Advances in Urology - April 25, 2019 Category: Urology & Nephrology Tags: Adv Urol Source Type: research

Novel Use of Household Items in Open and Robotic Surgical Skills Resident Education.
Conclusion: Low-fidelity training models can be used to improve surgical skills at a reasonable cost. The models will require further evaluation to determine construct validity and to determine how the improvements translate to OR performance. While high-fidelity simulators may continue to be utilized in formal surgical training, residents should be encouraged to supplement their training with innovative homemade models. PMID: 30962805 [PubMed] (Source: Advances in Urology)
Source: Advances in Urology - April 11, 2019 Category: Urology & Nephrology Tags: Adv Urol Source Type: research

Chlamydia trachomatis Growth and Cytokine mRNA Response in a Prostate Cancer Cell Line.
Authors: Petyaev IM, Zigangirova NA, Morgunova EY, Kyle NH, Fedina ED, Bashmakov YK Abstract In the present paper, we report that C. trachomatis can be efficiently propagated and affect mRNA expression for two major cytokines, relevant to tumor progression, in CWR-R1 cells, a malignant prostate cell line. CWR-R1 and McCoy cells, a classic cell line for chlamydial research, were grown and infected with C. trachomatis under similar conditions. Cell monolayers were harvested for RNA analysis and immunostaining with major outer membrane protein (MOMP) antibody at 24, 48, and 72 hours of the postinfection (hpi) period. ...
Source: Advances in Urology - February 26, 2019 Category: Urology & Nephrology Tags: Adv Urol Source Type: research

The Current Role of Osteoclast Inhibitors in Patients with Prostate Cancer.
Conclusion: Superiority of DEN over ZA has been proved only in advanced castrate refractory disease in terms of preventing new SRE. In the rest of the cases, the selection of either agent should be based on the clinical condition of each patient and the cost of the treatment. PMID: 30687403 [PubMed] (Source: Advances in Urology)
Source: Advances in Urology - January 30, 2019 Category: Urology & Nephrology Tags: Adv Urol Source Type: research

Comparison of Oxidative Effects of Two Different Administration Form of Oxybutynin in the Potential Target Tissues.
In this study, we aimed to compare the effects of oxybutynin on oxidative parameters in the potential target tissues of the oral and vaginal delivery. Female New Zealand white rabbits (n=12) were divided into two groups: oral delivery and vaginal delivery. The animals were sacrificed 48 h after administration and nitric oxide (NOx), thiobarbituric acid-reactive substances (TBARs), and glutathione (GSH) levels were determined spectrophotometrically in the aorta, salivary gland, and small intestine tissue samples. Vaginal delivery significantly decreased NOx levels in all tissue samples as compared to oral delivery (p
Source: Advances in Urology - January 26, 2019 Category: Urology & Nephrology Tags: Adv Urol Source Type: research

Quality of Health Information on the Internet for Prostate Cancer.
Conclusions: The lack of validated and unbiased websites for prostate cancer is concerning especially with increasing use of the Internet for health information. Websites sponsored or managed by the government and national departments were most likely to provide impartial health information for prostate cancer. We need to help our patients identify valid and unbiased online health resources. PMID: 30627152 [PubMed] (Source: Advances in Urology)
Source: Advances in Urology - January 12, 2019 Category: Urology & Nephrology Tags: Adv Urol Source Type: research

Alexis Wound Retractor for Radical Cystectomy: A Safe and Effective Method for Retraction.
Authors: Sidhu AS, Marten E, Bodoukhin N, Wayne G, Nagoda E, Bhandari A, Nieder AM Abstract Surgical site infection rates remain a common postoperative problem that continues to affect patients undergoing urologic surgery. Our study seeks to evaluate the difference in surgical site infection rates in patients undergoing open radical cystectomy when comparing the Bookwalter vs. the Alexis wound retractors. After institutional review board approval, we performed a retrospective chart review from February 2010 through August 2017 of patients undergoing open radical cystectomy with urinary diversion for bladder cancer....
Source: Advances in Urology - January 12, 2019 Category: Urology & Nephrology Tags: Adv Urol Source Type: research

Outcomes from the Introduction of a Combined Urology Outpatient Clinic.
Conclusions: The introduction of a combined urology outpatient clinic with the support of pre-clinic radiology meeting and synchronous urology CNS clinic facilitates patient discharge. PMID: 30627154 [PubMed] (Source: Advances in Urology)
Source: Advances in Urology - January 12, 2019 Category: Urology & Nephrology Tags: Adv Urol Source Type: research

The Benefits of Using a Small Caliber Ureteroscope in Evaluation and Management of Urethral Stricture.
Authors: Shahrour W, Joshi P, Hunter CB, Batra VS, Elmansy H, Surana S, Kulkarni S Abstract Introduction and Objective: The proper evaluation of urethral strictures is an essential part of the surgical planning in urethral reconstruction. The proper evaluation of the stricture can be challenging in certain situations, especially when the meatus is involved. We propose that the use of a small caliber ureteroscope (4.5 Fr and 6.5 Fr) can offer additional help and use for the surgical planning in urethroplasty. Methods: We prospectively collected data on 76 patients who underwent urethroplasties in K...
Source: Advances in Urology - December 27, 2018 Category: Urology & Nephrology Tags: Adv Urol Source Type: research

Analysis of the Learning Curve of Surgeons without Previous Experience in Laparoscopy to Perform Robot-Assisted Radical Prostatectomy.
Conclusions: Robot-assisted radical prostatectomy does not require previous experience in laparoscopic radical prostatectomy, but the learning curve is not short to achieve the plateau. PMID: 30510573 [PubMed] (Source: Advances in Urology)
Source: Advances in Urology - December 6, 2018 Category: Urology & Nephrology Tags: Adv Urol Source Type: research

Undescended Testes and Laparoscopy: Experience from the Developing World.
Conclusion: Laparoscopy clearly demonstrates the anatomy and provides visual information upon which a definitive decision can be made for further management of the undescended nonpalpable testis. PMID: 30473708 [PubMed] (Source: Advances in Urology)
Source: Advances in Urology - November 27, 2018 Category: Urology & Nephrology Tags: Adv Urol Source Type: research

The Modified Gil-Vernet Antireflux Surgery: A Successful Technique for High-Grade Vesicoureteral Reflux Correction in Children-Long-Term Follow-Up.
Conclusions: Our results are remarkable and compatible with other techniques' results. This simple and safe technique can correct bilateral VURs simultaneously; thus, it is rational to be considered for high-grade VUR correction. According to our results, we suggest the modified Gil-Vernet antireflux procedure for high-grade VUR correction as a simple, safe, and successful technique. This trial is registered with 67145/86/1233. PMID: 30420880 [PubMed] (Source: Advances in Urology)
Source: Advances in Urology - November 14, 2018 Category: Urology & Nephrology Tags: Adv Urol Source Type: research

Germ Cell Tumors: Updates on Epidemiology, Biology, and Treatment Considerations.
Authors: Bagrodia A, Albany C, Masterson TA PMID: 30210538 [PubMed] (Source: Advances in Urology)
Source: Advances in Urology - September 15, 2018 Category: Urology & Nephrology Tags: Adv Urol Source Type: research

Efficacy of Transdermal Oxybutynin in the Treatment of Overactive Bladder Syndrome: Does It Make Sense Using It in 2017?
Authors: Vozmediano-Chicharro R, Madurga B, Blasco P Abstract Objectives: Evaluation of changes in symptoms among patients with overactive bladder syndrome treated with transdermal oxybutynin and tolerability after 12 months of follow-up. Methods: This was a multicenter, retrospective, single-cohort, observational study. Changes in symptoms were evaluated primarily with a 3-day voiding diary. Results were compared to baseline. Subgroup analyses were performed in patients previously treated for OAB or not and aged 
Source: Advances in Urology - August 29, 2018 Category: Urology & Nephrology Tags: Adv Urol Source Type: research

A Review of Outcomes and Technique for the Robotic-Assisted Laparoscopic Retroperitoneal Lymph Node Dissection for Testicular Cancer.
Discussion: Encouraged by favorable early oncologic and safety outcomes for treatment of clinical stage (CS) I nonseminomatous germ cell tumor (NSGCT), the R-RPLND affords the same recovery advantages as the laparoscopic retroperitoneal lymph node dissection (L-RPLND) while offering greater dexterity, superior visualization, and a theoretically shorter learning curve for the surgeon. While R-RPLND has a promising future in the management of patients with primary and postchemotherapy NSGCT, larger and more vigorous prospective studies are needed before supplanting the open RPLND as the gold standard approach for primary low...
Source: Advances in Urology - June 3, 2018 Category: Urology & Nephrology Tags: Adv Urol Source Type: research

Pattern of Ureteric Pathology Presenting to a Fistula Centre in Western Kenya.
Conclusion: Highest proportion of ureteric pathologies was accounted for by iatrogenic causes and surgical repair and/or reimplantation has a high success rate. PMID: 29853870 [PubMed] (Source: Advances in Urology)
Source: Advances in Urology - June 3, 2018 Category: Urology & Nephrology Tags: Adv Urol Source Type: research

The Use of Modified Templates in Early and Advanced Stage Nonseminomatous Germ Cell Tumor.
Authors: Masterson TA, Cary C Abstract The surgical management of both early and advanced stage germ cell tumors of the testis remains a complex process of surgical decision making to maximize oncologic control while minimizing morbidity. Over the past 5 decades, the evolution of the surgical template for retroperitoneal lymphadenectomy (RPLND) has resulted in important modifications to achieve these goals. In this review, we will characterize the historical motivating factors that led to the modified template, outline patient and clinical factors in selecting these approaches in both early and advanced stage disea...
Source: Advances in Urology - June 2, 2018 Category: Urology & Nephrology Tags: Adv Urol Source Type: research

Adjuvant Therapy for Stage IB Germ Cell Tumors: One versus Two Cycles of BEP.
Authors: Huddart RA, Reid AM Abstract Testicular germ cell tumours are the commonest tumours of young men and are broadly managed either as pure seminomas or as 'nonseminomas'. The management of Stage 1 nonseminomatous germ cell tumours (NSGCTs), beyond surgical removal of the primary tumour at orchidectomy, is somewhat controversial. Cancer-specific survival rates in these patients are in the order of 99% regardless of whether surveillance, retroperitoneal lymph node dissection, or adjuvant chemotherapy is employed. However, the toxicities of these treatment modalities differ. Undertreating those destined to relap...
Source: Advances in Urology - May 31, 2018 Category: Urology & Nephrology Tags: Adv Urol Source Type: research

Experience with Renal Autotransplantation: Typical and Atypical Indications.
Conclusion: Renal autotransplantation is a rare, safe, and effective surgical procedure for the treatment of complex urologic conditions. In some instances, it may be of great utility for kidney salvage in some carefully selected patients. PMID: 29780413 [PubMed] (Source: Advances in Urology)
Source: Advances in Urology - May 23, 2018 Category: Urology & Nephrology Tags: Adv Urol Source Type: research

Antibiotic Prophylaxis with Trimethoprim-Sulfamethoxazole versus No Treatment after Mid-to-Distal Hypospadias Repair: A Prospective, Randomized Study.
Authors: Roth EB, Kryger JV, Durkee CT, Lingongo MA, Swedler RM, Groth TW Abstract Purpose: To evaluate the impact of prophylactic antibiotics after distal hypospadias repair on postoperative bacteriuria, symptomatic urinary tract infection, and postoperative complications in a prospective, randomized trial. Materials and Methods: Consecutive patients aged 6 months to 2 years were enrolled at our institution between June 2013 and May 2017. Consenting patients were randomized to antibiotic prophylaxis with trimethoprim-sulfamethoxazole versus no antibiotic. Patients had catheterized urine samples obtained at sur...
Source: Advances in Urology - May 23, 2018 Category: Urology & Nephrology Tags: Adv Urol Source Type: research

Urinary Bladder Cancer in Egypt: Are There Gender Differences in Its Histopathological Presentation?
Authors: Kyritsi F, Loffredo CA, Zheng YL, Philips G, Amr S Abstract We investigated gender differences in the histopathologic presentation of bladder cancer cases in Egypt, where both urothelial cell carcinoma (UC) and squamous cell carcinoma (SCC) types are highly prevalent. We used logistic regression to estimate the unadjusted (OR) and adjusted odds ratio (AOR) and 95% confidence interval (CI) of the associations between gender and different histopathologic and sociodemographic parameters of 2,186 confirmed cases of primary bladder cancer (1,775 males and 411 females; 784 SCC and 1,402 UC). There were no statis...
Source: Advances in Urology - May 9, 2018 Category: Urology & Nephrology Tags: Adv Urol Source Type: research

Immune-Related Concepts in Biology and Treatment of Germ-Cell Tumors.
Authors: Chovanec M, De Giorgi U, Mego M Abstract Germ-cell tumors (GCTs) are highly curable with chemotherapy. Salvage chemotherapy or surgery can cure a proportion of patients, but the ones failing these treatments will die of their disease in the young age. Immune checkpoint pathways are emerging as powerful targetable biomarkers, and a significant preclinical and clinical research is underway to widen our knowledge and expand the treatment possibilities with immune therapy. The concept of immune modulation that was currently adopted in many solid tumors is understudied in GCTs. Herein, we summarize the current ...
Source: Advances in Urology - May 9, 2018 Category: Urology & Nephrology Tags: Adv Urol Source Type: research

Conventional-Dose versus High-Dose Chemotherapy for Relapsed Germ Cell Tumors.
Authors: McHugh DJ, Feldman DR Abstract The majority of metastatic germ cell tumors (GCTs) are cured with cisplatin-based chemotherapy, but 20-30% of patients will relapse after first-line chemotherapy and require additional salvage strategies. The two major salvage approaches in this scenario are high-dose chemotherapy (HDCT) with autologous stem cell transplant (ASCT) or conventional-dose chemotherapy (CDCT). Both CDCT and HDCT have curative potential in the management of relapsed/refractory GCT. However, due to a lack of conclusive randomized trials, it remains unknown whether sequential HDCT or CDCT represents ...
Source: Advances in Urology - May 9, 2018 Category: Urology & Nephrology Tags: Adv Urol Source Type: research

Supine Percutaneous Nephrolithotripsy in Double-S Position.
Conclusions: This position is effective, safe, easy, and quick to prepare and allows for combined anterograde/retrograde operations. PMID: 29713340 [PubMed] (Source: Advances in Urology)
Source: Advances in Urology - May 3, 2018 Category: Urology & Nephrology Tags: Adv Urol Source Type: research

Combined Dorsal and Ventral Onlay Buccal Graft Technique for Large and Complex Penile Strictures.
Authors: Mertziotis N, Konandreas A, Kyratsas C Abstract Purpose: To present a modified technique of managing extensive penile urethral strictures with dorsal and ventral onlay buccal mucosa grafts. Patients and Methods: From October 2014 to January 2016, a total of 12 patients underwent urethroplasty for penile urethral strictures, using dorsal and ventral onlay grafts from buccal mucosa. The mean age was 42.75 (17-71). All patients completed the IPSS and QoL questionnaire, and uroflowmetry was done preoperatively. After surgery, the follow-up included completion of IPSS and QoL questionnaire and measuring of ...
Source: Advances in Urology - April 21, 2018 Category: Urology & Nephrology Tags: Adv Urol Source Type: research

Dissecting the Evolving Risk of Relapse over Time in Surveillance for Testicular Cancer.
Authors: Nayan M, Hamilton RJ Abstract Testicular cancer is the most common malignancy in young men, and the incidence is increasing in most countries worldwide. The vast majority of patients present with clinical stage I disease, and surveillance is being increasingly adopted as the preferred management strategy. At the time of diagnosis, patients on surveillance are often counselled about their risk of relapse based on risk factors present at diagnosis, but this risk estimate becomes less informative in patients that have survived a period of time without experiencing relapse. Conditional survival estimates, on t...
Source: Advances in Urology - April 21, 2018 Category: Urology & Nephrology Tags: Adv Urol Source Type: research

Toxicities Associated with Cisplatin-Based Chemotherapy and Radiotherapy in Long-Term Testicular Cancer Survivors.
Authors: Fung C, Dinh P, Ardeshir-Rouhani-Fard S, Schaffer K, Fossa SD, Travis LB Abstract Testicular cancer has become the paradigm of adult-onset cancer survivorship, due to the young age at diagnosis and 10-year relative survival of 95%. This clinical review presents the current status of various treatment-related complications experienced by long-term testicular cancer survivors (TCS) free of disease for 5 or more years after primary treatment. Cardiovascular disease and second malignant neoplasms represent the most common potentially life-threatening late effects. Other long-term adverse outcomes include neuro...
Source: Advances in Urology - April 21, 2018 Category: Urology & Nephrology Tags: Adv Urol Source Type: research

Adolescent and Young Adult Testicular Germ Cell Tumors: Special Considerations.
Authors: Saltzman AF, Cost NG Abstract While testicular germ cell tumors (T-GCTs) make up only 0.5% of pediatric malignancies and less than 2% of adult malignancies, they comprise 14% of adolescent malignancies, making it the most common solid tumor in this age group. The transition in incidence at this age is also accompanied by a transition in tumor histology with adolescents having mostly pure embryonal carcinoma and mixed nonseminomatous germ cell tumors. Similar to T-GCTs of all ages, surgical excision with orchiectomy is the standard initial step in treatment. Chemotherapy, retroperitoneal lymph node dissecti...
Source: Advances in Urology - April 19, 2018 Category: Urology & Nephrology Tags: Adv Urol Source Type: research

Spermatozoal Fractalkine Signaling Pathway Is Upregulated in Subclinical Varicocele Patients with Normal Seminogram and Low-Level Leucospermia.
Conclusion: Subclinical varicocele induces seminal and spermatozoal subclinical inflammatory response in the form of low-level leucospermia and increased mRNA expression of the fractalkine signaling pathway, leading to increased spermatozoal ROS production, oxidative stress, and DNA fragmentation. These could cooperate in the pathogenesis of delayed fertility in males with subclinical varicocele. PMID: 29527225 [PubMed] (Source: Advances in Urology)
Source: Advances in Urology - March 14, 2018 Category: Urology & Nephrology Tags: Adv Urol Source Type: research

Kidney Stone Disease: An Update on Current Concepts.
Authors: Alelign T, Petros B Abstract Kidney stone disease is a crystal concretion formed usually within the kidneys. It is an increasing urological disorder of human health, affecting about 12% of the world population. It has been associated with an increased risk of end-stage renal failure. The etiology of kidney stone is multifactorial. The most common type of kidney stone is calcium oxalate formed at Randall's plaque on the renal papillary surfaces. The mechanism of stone formation is a complex process which results from several physicochemical events including supersaturation, nucleation, growth, aggregation, ...
Source: Advances in Urology - March 10, 2018 Category: Urology & Nephrology Tags: Adv Urol Source Type: research

Pediatric Germ Cell Tumors: A Developmental Perspective.
Authors: Pierce JL, Frazier AL, Amatruda JF Abstract Germ cell tumors (GCTs) arising in infants, children, and adolescents present a set of special challenges. GCTs make up about 3% of malignancies in children aged 0-18 and nearly 15% of cancers in adolescents. Epidemiologic and molecular evidence suggests that GCTs in young children likely represent a distinct biologic group as compared to GCTs of older adolescents and adults. Despite this difference, pediatric GCTs are typically treated with cisplatin-based multiagent regimens similar to those used in adults. There is evidence that children are particularly vulne...
Source: Advances in Urology - March 10, 2018 Category: Urology & Nephrology Tags: Adv Urol Source Type: research

Retroperitoneal Lymph Node Dissection as Primary Treatment for Metastatic Seminoma.
Authors: Hu B, Daneshmand S Abstract Reducing the long-term morbidity in testicular cancer survivors represents a major area of interest. External beam radiation therapy and systemic chemotherapy are established treatments for seminoma; however, they are associated with late toxicities such as cardiovascular disease, insulin resistance, and secondary malignancy. Retroperitoneal lymph node dissection (RPLND) is a standard treatment for nonseminomatous germ cell tumors (NSGCT) that has minimal long-term morbidity. Given the efficacy of RPLND in management of NSGCT, interest has developed in this surgery as a front-li...
Source: Advances in Urology - March 1, 2018 Category: Urology & Nephrology Tags: Adv Urol Source Type: research

Impact on the Quality of Erections after Completing a Low-Intensity Extracorporeal Shock Wave Treatment Cycle on a Group of 710 Patients.
Authors: Ayala HAC, Cuartas JPS, Cleves DC Abstract Objective: The aim of this study is to evaluate the response to low-intensity extracorporeal shock wave therapy in a group of patients with organic vascular erectile dysfunction. Materials and Methods: This is an observational retrospective study. The researchers reviewed 710 patients with a clinical diagnosis of organic vascular erectile dysfunction (ED) of more than 3-month duration from male sexual health clinics of the Boston Medical Group from 12 cities in Spain and 4 in Mexico. Patients received 5 outpatient shock wave therapy sessions. They were evaluat...
Source: Advances in Urology - February 13, 2018 Category: Urology & Nephrology Tags: Adv Urol Source Type: research

Recent Pathophysiological Aspects of Peyronie's Disease: Role of Free Radicals, Rationale, and Therapeutic Implications for Antioxidant Treatment-Literature Review.
Authors: Paulis G, Romano G, Paulis L, Barletta D Abstract Peyronie's disease (PD) is a chronic inflammation of tunica albuginea of the corpora cavernosa that causes an inelastic plaque resulting in penis deformation. Although its etiology is not completely known, there is general consensus that PD is genetically transmitted and secondary to penile trauma. In recent years, numerous studies demonstrated the role played by oxidative stress in PD pathogenesis, and other studies have described successful use of antioxidants in PD treatment. Oxidative stress is an integral part of this disease, influencing its progressi...
Source: Advances in Urology - July 27, 2017 Category: Urology & Nephrology Tags: Adv Urol Source Type: research

The Persistence of Silodosin Monotherapy and the Reasons for Withdrawal from Treatment of Previously Untreated Japanese Patients with Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Hyperplasia.
CONCLUSIONS: 35.8% of previously untreated Japanese patients continued silodosin for 4 years. Many patients terminated silodosin for various reasons, the most frequent of which was symptom resolution. The effects of silodosin were maintained when the patients continued treatment. TRIAL REGISTRATION: This study was approved by the institutional review board of Hokkaido Prefectural Esashi Hospital (number 2007-2) and was registered in a public trial registry (UMIN000026910). PMID: 28694823 [PubMed] (Source: Advances in Urology)
Source: Advances in Urology - July 13, 2017 Category: Urology & Nephrology Tags: Adv Urol Source Type: research

A Study of Patients with Primary Mediastinal Germ Cell Tumors Treated Using Multimodal Therapy.
CONCLUSIONS: Reliable diagnosis and immediate multimodal treatments are necessary for patients with PMGCTs. The 6 patients treated in our hospital have never experienced recurrence after the multimodal treatment. PMID: 28634489 [PubMed] (Source: Advances in Urology)
Source: Advances in Urology - June 23, 2017 Category: Urology & Nephrology Tags: Adv Urol Source Type: research

Study of Testicular Structure in Fetuses with Prune Belly Syndrome.
Authors: Favorito LA, Costa SF, Costa WS, Vieiralves R, Bernardo FO, Sampaio FJB Abstract PURPOSE: To compare the structure of the testis in fetuses with prune belly syndrome (PBS) to normal controls. MATERIALS AND METHODS: We studied 6 testes obtained from 3 fetuses with PBS and 14 testes from 7 male fetuses. The testicular specimens were cut into 5-μm thick sections and stained with hematoxylin and eosin (HE), to observe the seminiferous tubules; Weigert's solution to observe elastic fibers; and picrosirius red to observe collagen. The images were captured with an Olympus BX51 microscope and Olympus DP70 c...
Source: Advances in Urology - June 14, 2017 Category: Urology & Nephrology Tags: Adv Urol Source Type: research