Macrophage-derived mir-100-5p orchestrates synovial proliferation and inflammation in rheumatoid arthritis through mTOR signaling
Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by synovial inflammation, causing substantial disability and reducing life quality. While macrophages are widely appreciated as a master... (Source: Journal of Nanobiotechnology)
Source: Journal of Nanobiotechnology - April 22, 2024 Category: Nanotechnology Authors: Huan Liu, Yuehong Chen, Yupeng Huang, Ling Wei, Jingjing Ran, Qianwei Li, Yunru Tian, Zhongling Luo, Leiyi Yang, Hongjiang Liu, Geng Yin and Qibing Xie Tags: Research Source Type: research
An exosomal strategy for targeting cancer-associated fibroblasts mediated tumors desmoplastic microenvironments
Tumors desmoplastic microenvironments are characterized by abundant stromal cells and extracellular matrix (ECM) deposition. Cancer-associated fibroblasts (CAFs), as the most abundant of all stromal cells, pla... (Source: Journal of Nanobiotechnology)
Source: Journal of Nanobiotechnology - April 21, 2024 Category: Nanotechnology Authors: Xiaoxia Xue, Xiangpeng Wang, Mingshi Pang, Liuchunyang Yu, Jinxiu Qian, Xiaoyu Li, Meng Tian, Cheng Lu, Cheng Xiao and Yuanyan Liu Tags: Review Source Type: research
Exosomal miR-9-5p derived from iPSC-MSCs ameliorates doxorubicin-induced cardiomyopathy by inhibiting cardiomyocyte senescence
Doxorubicin (DOX) is a chemotherapeutic agent widely used for tumor treatment. Nonetheless its clinical application is heavily limited by its cardiotoxicity. There is accumulated evidence that transplantation ... (Source: Journal of Nanobiotechnology)
Source: Journal of Nanobiotechnology - April 20, 2024 Category: Nanotechnology Authors: Huifeng Zheng, Xiaoting Liang, Baojuan Liu, Xinran Huang, Ying Shen, Fang Lin, Jiaqi Chen, Xiaoyan Gao, Haiwei He, Weifeng Li, Bei Hu, Xin Li and Yuelin Zhang Tags: Research Source Type: research
Hydralazine loaded nanodroplets combined with ultrasound-targeted microbubble destruction to induce pyroptosis for tumor treatment
Pyroptosis, a novel type of programmed cell death (PCD), which provides a feasible therapeutic option for the treatment of tumors. However, due to the hypermethylation of the promoter, the critical protein Gas... (Source: Journal of Nanobiotechnology)
Source: Journal of Nanobiotechnology - April 20, 2024 Category: Nanotechnology Authors: Shuting Huang, Mengmeng Shang, Lu Guo, Xiao Sun, Shan Xiao, Dandan Shi, Dong Meng, Yading Zhao, Xiaoxuan Wang, Rui Liu and Jie Li Tags: Research Source Type: research
Recent advances in enhances peripheral nerve orientation: the synergy of micro or nano patterns with therapeutic tactics
Several studies suggest that topographical patterns influence nerve cell fate. Efforts have been made to improve nerve cell functionality through this approach, focusing on therapeutic strategies that enhance ... (Source: Journal of Nanobiotechnology)
Source: Journal of Nanobiotechnology - April 20, 2024 Category: Nanotechnology Authors: Majid Sharifi, Mohammad Kamalabadi-Farahani, Majid Salehi, Somayeh Ebrahimi-Barough and Morteza Alizadeh Tags: Review Source Type: research
Modulation of alveolar macrophage and mitochondrial fitness by medicinal plant-derived nanovesicles to mitigate acute lung injury and viral pneumonia
Acute lung injury (ALI) is generally caused by severe respiratory infection and characterized by overexuberant inflammatory responses and inefficient pathogens-containing, the two major processes wherein alveo... (Source: Journal of Nanobiotechnology)
Source: Journal of Nanobiotechnology - April 18, 2024 Category: Nanotechnology Authors: Lusha Ye, Yanan Gao, Simon Wing Fai Mok, Wucan Liao, Yazhou Wang, Changjiang Chen, Lijun Yang, Junfeng Zhang and Liyun Shi Tags: Research Source Type: research
Circulating tumor cell-derived exosome –transmitted long non-coding RNA TTN-AS1 can promote the proliferation and migration of cholangiocarcinoma cells
Exosomes assume a pivotal role as essential mediators of intercellular communication within tumor microenvironments. Within this context, long noncoding RNAs (LncRNAs) have been observed to be preferentially s... (Source: Journal of Nanobiotechnology)
Source: Journal of Nanobiotechnology - April 18, 2024 Category: Nanotechnology Authors: Xu Zhou, Xiaohan Kong, Jun Lu, Heng Wang, Meng Liu, Shuchao Zhao, Zhaozhi Xia, Qinggong Liu, Hongrui Sun, Xin Gao, Chaoqun Ma, Zheyu Niu, Faji Yang, Xie Song, Hengjun Gao, Shizhe Zhang & hellip; Tags: Research Source Type: research
Tea polyphenol-engineered hybrid cellular nanovesicles for cancer immunotherapy and androgen deprivation therapy
Androgen deprivation therapy (ADT) is a crucial and effective strategy for prostate cancer, while systemic administration may cause profound side effects on normal tissues. More importantly, the ADT can easily... (Source: Journal of Nanobiotechnology)
Source: Journal of Nanobiotechnology - April 18, 2024 Category: Nanotechnology Authors: Yiming Guo, Jicheng Wu, Lefan Chen, Lujie Liu, Tianxiang Bi, Yuanwei Pan, Qian-Fang Meng, Chaoliang Wang, Lang Rao and Qi Li Tags: Research Source Type: research
DNA-based molecular classifiers for the profiling of gene expression signatures
Although gene expression signatures offer tremendous potential in diseases diagnostic and prognostic, but massive gene expression signatures caused challenges for experimental detection and computational analy... (Source: Journal of Nanobiotechnology)
Source: Journal of Nanobiotechnology - April 17, 2024 Category: Nanotechnology Authors: Li Zhang, Qian Liu, Yongcan Guo, Luyao Tian, Kena Chen, Dan Bai, Hongyan Yu, Xiaole Han, Wang Luo, Tong Feng, Shixiong Deng and Guoming Xie Tags: Research Source Type: research
Swim bladder-derived biomaterials: structures, compositions, properties, modifications, and biomedical applications
Animal-derived biomaterials have been extensively employed in clinical practice owing to their compositional and structural similarities with those of human tissues and organs, exhibiting good mechanical prope... (Source: Journal of Nanobiotechnology)
Source: Journal of Nanobiotechnology - April 17, 2024 Category: Nanotechnology Authors: Xiaorong Lan, Mingdong Luo, Meiling Li, Linpeng Mu, Guangwen Li, Gong Chen, Zhoukun He and Jingang Xiao Tags: Review Source Type: research
A tempo-spatial controllable microfluidic shear-stress generator for in-vitro mimicking of the thrombus
Pathological conditions linked to shear stress have been identified in hematological diseases, cardiovascular diseases, and cancer. These conditions often exhibit significantly elevated shear stress levels, su... (Source: Journal of Nanobiotechnology)
Source: Journal of Nanobiotechnology - April 17, 2024 Category: Nanotechnology Authors: Zhihang Yu, Yiqun Chen, Jingjing Li, Chang Chen, Huaxiu Lu, Siyuan Chen, Tingting Zhang, Tianruo Guo, Yonggang Zhu, Jing Jin, Sheng Yan and Huaying Chen Tags: Research Source Type: research
Systematic review of the osteogenic effect of rare earth nanomaterials and the underlying mechanisms
Rare earth nanomaterials (RE NMs), which are based on rare earth elements, have emerged as remarkable biomaterials for use in bone regeneration. The effects of RE NMs on osteogenesis, such as promoting the ost... (Source: Journal of Nanobiotechnology)
Source: Journal of Nanobiotechnology - April 16, 2024 Category: Nanotechnology Authors: Ziwei Chen, Xiaohe Zhou, Minhua Mo, Xiaowen Hu, Jia Liu and Liangjiao Chen Tags: Review Source Type: research
Mesoporous silica coated spicules for photodynamic therapy of metastatic melanoma
We report on the fabrication of mesoporous silicon dioxide coated Haliclona sp. spicules (mSHS) to enhance the delivery of the insoluble photosensitizer protoporphyrin IX (PpIX) into deep skin layers and mediate ... (Source: Journal of Nanobiotechnology)
Source: Journal of Nanobiotechnology - April 15, 2024 Category: Nanotechnology Authors: Xuejiao Liang, Jialiang Zhang, Chi Zhang, Haojie Zhai, Ping Yang and Ming Chen Tags: Research Source Type: research
A pH-responsive nanoplatform with dual-modality imaging for enhanced cancer phototherapy and diagnosis of lung metastasis
To address the limitations of traditional photothermal therapy (PTT)/ photodynamic therapy (PDT) and real-time cancer metastasis detection, a pH-responsive nanoplatform (NP) with dual-modality imaging capabili... (Source: Journal of Nanobiotechnology)
Source: Journal of Nanobiotechnology - April 15, 2024 Category: Nanotechnology Authors: Mujie Yuan, Zeyu Han, Yan Li, Xin Zhan, Yong Sun, Bin He, Yan Liang, Kui Luo and Fan Li Tags: Research Source Type: research
The application of phenylboronic acid pinacol ester functionalized ROS-responsive multifunctional nanoparticles in the treatment of Periodontitis
Periodontitis is an inflammatory disease induced by the complex interactions between the host immune system and the microbiota of dental plaque. Oxidative stress and the inflammatory microenvironment resulting... (Source: Journal of Nanobiotechnology)
Source: Journal of Nanobiotechnology - April 15, 2024 Category: Nanotechnology Authors: Jinhong Chen, Aihua Luo, Mengmeng Xu, Yao Zhang, Zheng Wang, Shuang Yu, Li Zhu, Wei Wu and Deqin Yang Tags: Research Source Type: research
