Ultrastructural analysis of bone formation around dental implants in nondiabetic rats, severe diabetics not controlled and controlled with insulin.
CONCLUSION: Severe diabetes caused ultrastructural changes in bone formation, and insulin therapy allowed an improvement in osseointegration, but it was not possible to reach the results obtained in the control group. PMID: 33331451 [PubMed - indexed for MEDLINE] (Source: Acta Cirurgica Brasileira)
Source: Acta Cirurgica Brasileira - December 20, 2020 Category: Surgery Authors: Souza ACR, Tedesco BAN, Lourenção PLTA, Terra SA, Araújo CDRP, Spadella CT, Ortolan EVP Tags: Acta Cir Bras Source Type: research

The effect of activated protein C in the experimental disseminated intravascular coagulation model formed by lipopolysaccharide infusion.
l;zer N Abstract PURPOSE: In this experimental study, activated protein C (APC), which has anticoagulant, antithrombotic, profibrinolytic, anti-inflammatory and antiapoptotic properties, was used to prevent coagulopathy in a disseminated intravascular coagulation (DIC) model formatted with lipopolysaccharide (LPS) infusion. METHODS: Twenty-five Wistar albino rats weighting 280 - 320 g each were used. They were randomly divided into three groups: sham, control and study groups. To sham group (n = 5), only normal saline was infused. To control (n = 10) and study groups (n = 10), 30 mg/kg LPS was infused for 4 h...
Source: Acta Cirurgica Brasileira - December 20, 2020 Category: Surgery Authors: Öahin A, Özer N Tags: Acta Cir Bras Source Type: research

Tensiometric evaluation of the effect of lowfrequency electric stimulation on healing Achilles tendons in rats.
CONCLUSION: Low-frequency electric stimulation increased the resistance of the tendons at 2 and 6 weeks of evolution in rats. PMID: 33331453 [PubMed - indexed for MEDLINE] (Source: Acta Cirurgica Brasileira)
Source: Acta Cirurgica Brasileira - December 20, 2020 Category: Surgery Authors: Casagrande SM, Biondo-Simões MLP, Berti LF, Robes RR, Biondo-Simões R, Nakadomari TS, Henning Junior L Tags: Acta Cir Bras Source Type: research

A modified rabbit model of tracheal stenosis and a household endoscope. More simplicity and accessibility.
CONCLUSION: The modified model is simpler, minimally invasive and reliable, while the household endoscope is competent for model's follow-up, providing easily accessible and useful tools for facilitating more extensive studies of benign tracheal stenosis. PMID: 33331454 [PubMed - indexed for MEDLINE] (Source: Acta Cirurgica Brasileira)
Source: Acta Cirurgica Brasileira - December 20, 2020 Category: Surgery Authors: Zhang G, Wang J, Zeng Y Tags: Acta Cir Bras Source Type: research

Benefits of pentoxifylline for skin flap tissue repair in rats.
Abstract PURPOSE: To assess the action of pentoxifylline, administered by subcutaneous route, on skin flap tissue repair in rats, and to verify the histological aspects and biomarkers. METHODS: Thirty-two male Wistar rats were divided into four groups: control (CT) and treated with pentoxifylline (P1, P3 and P5). Modified McFarlane technique flap was used. Ten days later, the animals were euthanized and the areas of viable and necrotic tissue were evaluated. Hematoxylin/eosin staining was used to assess the morphometric characteristics of the number of vessels and epithelial thickness. Picrosirius red was use...
Source: Acta Cirurgica Brasileira - December 20, 2020 Category: Surgery Authors: Pedretti SLDC, Rena CL, Orellano LAA, Lazari MG, Campos PP, Nunes TA Tags: Acta Cir Bras Source Type: research

Stereological study and analysis of oxidative stress during renal aging in rats.
CONCLUSIONS: Morphometric and stereological analyses revealed a gradual decrease in the volume and density of renal glomeruli during aging, as well as kidney atrophy. These findings related to oxidative stress clarify many changes occurring in kidney tissues during senescence in rats. PMID: 33331456 [PubMed - indexed for MEDLINE] (Source: Acta Cirurgica Brasileira)
Source: Acta Cirurgica Brasileira - December 20, 2020 Category: Surgery Authors: Melchioretto EF, Zeni M, Veronez DADL, Filipak Neto F, Digner IS, Fraga R Tags: Acta Cir Bras Source Type: research

Investigation of the effects of systemic meperidine administration on fascia healing in an experimental rat model.
Abstract PURPOSE: To evaluate the effects of meperidine on fascial healing. METHODS: Seventy adult male Sprague-Dawley rats divided into 7 groups with 10 rats in each group. One of these groups was determined as the sham group, 3 of the remaining 6 groups as meperidine groups, and 3 as control groups. These were grouped as 1st, 2nd, and 6th weeks. In the anterior abdominal wall of the rat, the skin was detached and a wound model including the peritoneum was created with a median incision. Mice in the meperidine group were injected with meperidine intraperitoneally (IP) 3 × 20 mg/kg meperidine on postope...
Source: Acta Cirurgica Brasileira - December 20, 2020 Category: Surgery Authors: Sensoy E, Akcan AC, Korkmaz M, Elmalı F, Topal U, Akgun H, Muhtaroglu S Tags: Acta Cir Bras Source Type: research

Simulated training model of ureteropyelic anastomosis in laparoscopic pyeloplasty.
CONCLUSION: We noticed improvement in the ability to perform the ureteropelvic anastomosis by participants with no experience with it. Therefore, even unexperienced participants can improve their skills with this training. Moreover, we observed the effectiveness of the model use, confirmed by the participants' opinion and its validation by expert surgeons. PMID: 33331458 [PubMed - indexed for MEDLINE] (Source: Acta Cirurgica Brasileira)
Source: Acta Cirurgica Brasileira - December 20, 2020 Category: Surgery Authors: Lima JCS, Rocha HAL, Mesquita FJC, Araújo DABS, Silveira RAD, Borges GC Tags: Acta Cir Bras Source Type: research

Evaluation of a collagen matrix in a mandible defect in rats submitted to the use of bisphosphonates.
Abstract PURPOSE: To assess the effect of a collagen matrix (Mucograft®) on the inflammatory process in a semi-critical experimental defect model in rats treated with bisphosphonates. METHODS: Eighteen Wistar rats were randomly divided into three groups: saline (CG), alendronate (ALD) 5mg/kg (AG) or zoledronic acid (ZA) 0.2mg/kg (ZG). ALD was administered orally for 10 weeks and ZA was administered intravascularly on days 0, 7 and 14 and 49. On day 42, a 2mm defect was created and filled with Mucograft® collagen matrix. The contralateral side was filled with a clot (control side). The animals were eut...
Source: Acta Cirurgica Brasileira - December 3, 2020 Category: Surgery Authors: Cunha VV, Silva PGB, Lemos JVM, Martins JOL, Freitas MO, Avelar RL Tags: Acta Cir Bras Source Type: research

JPEG and raw image files compared to direct measurement of the breast region.
Abstract PURPOSE: To compare JPEG and RAW image file extensions to direct measurement of the breast region. METHODS: Points were marked on the breasts and arms of 40 female volunteers. The joining of these points in each hemibody formed seven linear segments, one angular segment and one median segment common to both hemibodies. Volunteers were photographed in a standardized fashion and evaluated by three raters using the software Adobe Photoshop CS6® and three image file extensions (RAW, high resolution JPEG and low resolution JPEG); values were compared to direct anthropometry. RESULTS: All variable...
Source: Acta Cirurgica Brasileira - December 3, 2020 Category: Surgery Authors: Quieregatto PR, Sabino Neto M, Furtado F, Quieregatto ADA, Trigo Junior TW, Ferreira LM Tags: Acta Cir Bras Source Type: research

Periplaneta americana extract promotes intestinal mucosa repair of ulcerative colitis in rat.
CONCLUSIONS: The data suggest that Periplaneta americana extract may be a potential compound for the treatment of colonic lesions. The mechanism may be related to inhibiting the secretion of IL-13 and promoting the formation of EGF. PMID: 33237174 [PubMed - as supplied by publisher] (Source: Acta Cirurgica Brasileira)
Source: Acta Cirurgica Brasileira - November 26, 2020 Category: Surgery Authors: Xue NN, He M, Li Y, Wu JZ, Du WW, Wu XM, Yang ZZ, Zhang CG, Li QY, Xiao H Tags: Acta Cir Bras Source Type: research

The influence of splenic tissue on the survival and TCD4 and TCD8 lymphocyte rates in rats subjected to fecal peritonitis induction.
CONCLUSION: The maintenance of splenic tissue contributed to increase the survival of rats and there was a change in the number of TCD8 lymphocytes. PMID: 33237175 [PubMed - as supplied by publisher] (Source: Acta Cirurgica Brasileira)
Source: Acta Cirurgica Brasileira - November 26, 2020 Category: Surgery Authors: Borjaili ASD, Nunes GC, Silveira JB, Dall'Orto FH, Lorenzoni GS, Borjaili MED, Campagnaro BP, Lima MCM, Paulo MSL, Paulo DNS, Nunes TA Tags: Acta Cir Bras Source Type: research

A microsurgical technique for catheter insertion in the rat femoral artery.
CONCLUSIONS: We developed a surgical catheterization method using the introducer in small animals. This could potentially reduce the frequency of the insertion with catheter-based errors and insertion time. PMID: 33237176 [PubMed - as supplied by publisher] (Source: Acta Cirurgica Brasileira)
Source: Acta Cirurgica Brasileira - November 26, 2020 Category: Surgery Authors: Sugai K, Hakamata Y, Tamura T, Kataoka M, Fujisawa M, Sano M, Kobayashi E Tags: Acta Cir Bras Source Type: research

Effects of homologous and heterologous rich platelets plasma, compared to poor platelets plasma, on cutaneous healing of rabbits.
CONCLUSIONS: Heterologous PRP contributed with more tissue retraction at the beginning of the wound healing process. After this, there were no differences on the wound healing skin process treated with PRP or PPP. However, our findings suggest the presence of others plasmatic factors, besides platelets, which could also contribute to the wound healing process, and thus, should be further investigated. PMID: 33237177 [PubMed - as supplied by publisher] (Source: Acta Cirurgica Brasileira)
Source: Acta Cirurgica Brasileira - November 26, 2020 Category: Surgery Authors: Meira RO, Braga DNM, Pinheiro LSG, Amorim IFG, Vasconcellos LS, Alberti LR Tags: Acta Cir Bras Source Type: research

Is there something new regarding triceps brachii muscle insertion?
mo AL Abstract PURPOSE: Previous studies have questioned whether the triceps brachii muscle tendon (TBMT) has a double or single insertion on the ulna. Aiming to provide an answer, we describe the anatomy of the TBMT and review a magnetic resonance imaging (MRI) series of the elbow. METHODS: Forty-one elbows were dissected to assess the details of the triceps brachii insertion. Elbow plastination slices were analyzed to determine whether there was a space on the TBMT. Magnetic resonance imaging from the records of the authors were also obtained to demonstrate the appearance of the pre-tricipital space on MRI....
Source: Acta Cirurgica Brasileira - November 26, 2020 Category: Surgery Authors: Akamatsu FE, Negrão JR, Rodrigues MB, Itezerote AM, Saleh SO, Hojaij F, Andrade M, Jacomo AL Tags: Acta Cir Bras Source Type: research

Biomechanical and adhesion comparison of linea alba prophylactic reinforcement with coated and uncoated three-dimensional T-shaped mesh in rabbits.
Abstract PURPOSE: Incisional hernia (IH) is a frequent complication of median laparotomy. The use of prophylactic mesh to reduce IH incidence has gained increasing attention. We hypothesized that in an animal model, linea alba prophylactic reinforcement with a three-dimensional T-shaped polypropylene mesh results in greater abdominal wall resistance. METHODS: Study was performed in 27 rabbits. After abdominal midline incision, animals were divided into three groups according to the laparotomy closure method used: (1)3D T-shaped coated mesh; (2)3D T-shaped uncoated mesh; and (3) closure without mesh. After 4 m...
Source: Acta Cirurgica Brasileira - November 20, 2020 Category: Surgery Authors: Hernani BL, Barros PHF, Tastaldi L, Ladeira LN, Roll S, Ferreira FG, Garcia DPC Tags: Acta Cir Bras Source Type: research

Exploring the role of neurogenic pathway-linked cholecystokinin release in remote preconditioning-induced cardioprotection.
CONCLUSION: RIP activates the neurogenic pathway that may increase the plasma levels of CCK, which may act on the heart-localized CCK receptors to produce cardioprotection against I/R injury. PMID: 33146235 [PubMed - in process] (Source: Acta Cirurgica Brasileira)
Source: Acta Cirurgica Brasileira - November 6, 2020 Category: Surgery Authors: Li H, An C Tags: Acta Cir Bras Source Type: research

Erratum.
ERRATUM. Acta Cir Bras. 2020 Oct 28;35(10):e202000903err Authors: Abstract [This corrects the article doi: 10.1590/s0102-865020200090000003]. PMID: 33146239 [PubMed] (Source: Acta Cirurgica Brasileira)
Source: Acta Cirurgica Brasileira - October 28, 2020 Category: Surgery Tags: Acta Cir Bras Source Type: research

Macro and microscopic comparison of the upper pole of the spleen with the lower pole in partial splenectomy.
CONCLUSION: There was no significant difference regarding the viability of UP and LP, in macroscopy and microscopy. PMID: 33084734 [PubMed - in process] (Source: Acta Cirurgica Brasileira)
Source: Acta Cirurgica Brasileira - October 23, 2020 Category: Surgery Authors: Paulo LNL, Alexander DR, Vallandro EID, Benevides RA, Motta LLD, Paulo MSL, Paulo DNS Tags: Acta Cir Bras Source Type: research

The examination of the nephroprotective effect of montelukast sodium and N-acetylcysteine ın renal ıschemia with dimercaptosuccinic acid imaging in a placebo-controlled rat model.
uuml;menoğlu S, Huri E Abstract PURPOSE: To determine the nephroprotective effect of NAC and Montelukast Sodium administration against the development of renal damage associated with long warm renal ischemia. METHODS: Twenty-seven rats were randomly divided into 3 study groups, which received NAC, montelukast and placebo, and 3 rats were included in the sham-treated control group. Medications were given 3 days before the procedure. DMSA renal scintigraphy was performed before and after surgery. The right renal pedicle was occluded for 45 min to induce ischemia and then subjected to reperfusion for 6 h (I/R g...
Source: Acta Cirurgica Brasileira - October 23, 2020 Category: Surgery Authors: Aydin A, Sunay MM, Karakan T, Özcan S, Hasçiçek AM, Yardimci İ, Surer H, Korkmaz M, Hücümenoğlu S, Huri E Tags: Acta Cir Bras Source Type: research

The outcomes of dexmedetomidine and calcitriol on flap viability.
rkmaz M Abstract PURPOSE: To evaluate protective effects of dexmedetomidine, calcitriol and their combination. METHODS: Forty Wistar-albino rats were divided into 4 groups; group of Sham (Group Sham); group of dexmedetomidine (Group DEX); group of calcitriol (Group CAL) and group of dexmedetomidineandcalcitriol (Group DEX-CAL). Photographic analysis was used for macroscopic analysis and perfusion analyses were evaluated by scintigraphy. Additionally, tissue malondialdehyde (MDA) and total oxidant status (TOS) and total antioxidant activity (TAS) were recorded and oxidative stress index (OSI) was calculated. E...
Source: Acta Cirurgica Brasileira - October 8, 2020 Category: Surgery Authors: Kotanoğlu MS, Akbulut A, Gürsoy K, Koca G, Özcan N, Yumuşak N, Şenes M, Kırtıl G, Korkmaz M Tags: Acta Cir Bras Source Type: research

Omeprazole and adenocarcinoma in the stomach of rats submitted to duodenogastric reflux. Is there a protective effect?
CONCLUSIONS: The occurrence of squamous hyperplasia, adenomatous hyperplasia and adenocarcinoma increased after gastrojejunal anastomoses, which cause duodenogastric reflux. The association of omeprazole did not protect the development of proliferative lesions and cancer induced by duodenogastric reflux in rats. PMID: 33027361 [PubMed - as supplied by publisher] (Source: Acta Cirurgica Brasileira)
Source: Acta Cirurgica Brasileira - October 8, 2020 Category: Surgery Authors: Monteiro RLR, Kobayasi MAMR, Araujo MR, Monteiro DR, Andreollo NA Tags: Acta Cir Bras Source Type: research

Antibiotic prophylaxis in breast cancer surgery. A randomized controlled trial.
CONCLUSION: Antibiotic prophylaxis had no significant effect on reducing SSI rates in women without independent risk factors for SSI undergoing breast cancer surgery. PMID: 33027362 [PubMed - as supplied by publisher] (Source: Acta Cirurgica Brasileira)
Source: Acta Cirurgica Brasileira - October 8, 2020 Category: Surgery Authors: Prudencio RMA, Campos FSM, Loyola ABAT, Archangelo Junior I, Novo NF, Ferreira LM, Veiga DF Tags: Acta Cir Bras Source Type: research

Evaluation of Indigo carmine on hepatic ischemia and reperfusion injury.
CONCLUSION: IC was not able to protect mitochondria from IR injury and proved to be a potentiating agent, acting in synergy with the IR injury promoting damage to the hepatocyte membranes. PMID: 32996998 [PubMed - in process] (Source: Acta Cirurgica Brasileira)
Source: Acta Cirurgica Brasileira - October 3, 2020 Category: Surgery Authors: Rancan EA, Frota EI, Freitas TMN, Jordani MC, Évora PRB, Castro-E-Silva O Tags: Acta Cir Bras Source Type: research

Laparoscopic bowel resection of deep infiltrating endometriosis. Comparative outcomes of a public teaching hospital and a referral private hospital.
Abstract PURPOSE: To compare the operative outcomes of laparoscopic surgical treatment for bowel endometriosis in a public teaching hospital versus in a private referral hospital. METHODS: The indications for surgery, type and time of operation, length of hospital stay, need for a temporary stoma, rate of conversion to open surgery, and postoperative complications were evaluated. RESULTS: One hundred eighty-one patients were included (150 patients, 82.9%, in a private hospital). In the private hospital, there were more patients with infertility [56% vs. 29%; P=0.01] as an indication for surgery) and segm...
Source: Acta Cirurgica Brasileira - October 3, 2020 Category: Surgery Authors: Parra RS, Feitosa MR, Valerio FP, Camargo HP, Zanardi JVC, Feres O, Rocha JJRD, Rosa-E-Silva JC Tags: Acta Cir Bras Source Type: research

Surgical and postoperative evaluations of rectal adenomas excised with a rigid proctoscope.
CONCLUSIONS: The described proctoscope proved to be a viable technique with results similar to other techniques, with the advantage that it allowed greater accessibility for surgeons. Therefore, its use could be implemented and become widespread in surgical practice. PMID: 32965304 [PubMed - as supplied by publisher] (Source: Acta Cirurgica Brasileira)
Source: Acta Cirurgica Brasileira - September 24, 2020 Category: Surgery Authors: Lima RDAL, Parra RS, Feitosa MR, Feres O, Rocha JJRD Tags: Acta Cir Bras Source Type: research

Viral infections of pigs used for medical education. A Japanese experience.
Abstract Infectious viruses pose a threat to all living organisms, including humans, and can cause significant morbidity. Previous experience with pigs in medical education and research, rather than in domestic control settings, has led to a unique perspective on viral infections in swine. In this article, common porcine infectious diseases have been listed, based mainly on the authors' experience thus far. For example, young domestic pigs that were used in surgical training and infected with hepatitis E were subjected to quarantine and isolation treatment, and attempts were made to develop a DNA vaccine for swine...
Source: Acta Cirurgica Brasileira - September 24, 2020 Category: Surgery Authors: Kobayashi E Tags: Acta Cir Bras Source Type: research

The effect of probiotics on ıntestinal motility in an experimental short bowel model.
CONCLUSION: We suggest that early use of probiotics may significantly regulate bowel motility, and accordingly improve absorption of nutrients in short bowel syndrome. PMID: 32901681 [PubMed - in process] (Source: Acta Cirurgica Brasileira)
Source: Acta Cirurgica Brasileira - September 6, 2020 Category: Surgery Authors: Metin M, Altun A, Köylüoğlu G Tags: Acta Cir Bras Source Type: research

Chronic alcoholism associated with diabetes induced apoptosis in the corpus cavernosum of rats.
CONCLUSIONS: The association of these factors (ethanol and diabetes) probably can affect the apoptosis mechanism in lesions of the cavernous tissue in the rat penis. Both gene and protein expression of Caspase-9 in diabetic and ethanol-diabetic groups suggest the involvement of the apoptosis cascade from this study model. PMID: 32901682 [PubMed - in process] (Source: Acta Cirurgica Brasileira)
Source: Acta Cirurgica Brasileira - September 6, 2020 Category: Surgery Authors: Schimming BC, Cirino MLA, Lizarte Neto FS, Novais PC, Carvalho CAM, Tirapelli DPDC, Molina CAF, Tirapelli LF, Tucci Junior S Tags: Acta Cir Bras Source Type: research

Three-dimensional laparoscopic Roux-en-Y gastric bypass with totally hand-sewn anastomoses for morbid obesity. A single center experience.
Abstract PURPOSE: To assess the impact of three-dimensional (3D) vision use on operative time (OT) in laparoscopic Roux-en-Y gastric bypass (LRYGB) with hand-sewn anastomoses. METHODS: We analyzed a prospectively collected database of patients who underwent LRYGB. We included all patients operated on with either 2D or 3D vision. Demographics and clinical characteristics, operative time, hospital stay and 30-day postoperative complications were collected for all patients and analyzed. RESULTS: During the study time, out of 143 patients who underwent LRYGB for morbid obesity, 111 were considered eligible. ...
Source: Acta Cirurgica Brasileira - September 6, 2020 Category: Surgery Authors: Mongelli F, Regina D, Garofalo F, Vannelli A, Giuseppe MD, FitzGerald M, Marengo M Tags: Acta Cir Bras Source Type: research

Characterization and assessment of the genotoxicity and biocompatibility of poly (hydroxybutyrate) and norbixin membranes.
Abstract Purpose To synthesize and characterize poly(hydroxybutyrate) (PHB) and norbixin membranes to evaluate them for genotoxicity in rats and wound healing in mice by histological staining. Methods For the evaluation of genotoxicity, male rats ( Rattus novegicus ) were divided into three groups (n= 5): 5% PHB/Norbixin membrane introduced into the peritoneum by laparotomy; B - negative control; C - positive control (intraperitoneal dose of cyclophosphamide 50 mg/kg). For the evaluation of biocompatibilty, a cutaneous wound was induced on the back of males mice ( Mus musculus ) divided into two experimental treat...
Source: Acta Cirurgica Brasileira - September 4, 2020 Category: Surgery Authors: Sousa RC, Carvalho LFM, Maia Filho ALM, Ferreira DCL, Amaral FPMD, Mendes LMS, Viana VGF Tags: Acta Cir Bras Source Type: research

Criteria for assessing peripheral nerve injury. Behavioral and functional assessment in non-operated Wistar rats.
Conclusions The behavioral and functional assessment of peripheral nerve regeneration are low-cost, easy to perform, and reliable tests. However, they need to be performed by experienced researchers to avoid misinterpretation. PMID: 32813758 [PubMed - in process] (Source: Acta Cirurgica Brasileira)
Source: Acta Cirurgica Brasileira - August 21, 2020 Category: Surgery Authors: Teixeira RKC, Calvo FC, Santos DRD, Araújo NP, Tramontin DF, Costa LVPD, Barros RSM Tags: Acta Cir Bras Source Type: research

PPARG expression in colorectal cancer and its association with staging and clinical evolution.
Conclusion Expression of PPARGD was not associated with worse prognosis. PMID: 32813759 [PubMed - in process] (Source: Acta Cirurgica Brasileira)
Source: Acta Cirurgica Brasileira - August 21, 2020 Category: Surgery Authors: Villa ALP, Parra RS, Feitosa MR, Camargo HP, Machado VF, Tirapelli DPDC, Rocha JJRD, Feres O Tags: Acta Cir Bras Source Type: research

A non-inferiority study to compare daily fast-acting insulin versus twice a week slow-acting insulin-moderate diabetes mode.
Conclusion The use of slow-acting-insulin is not inferior to the use of fast-acting-insulin in the management of partially insulin-controlled moderate diabetes in rats. PMID: 32813772 [PubMed - in process] (Source: Acta Cirurgica Brasileira)
Source: Acta Cirurgica Brasileira - August 21, 2020 Category: Surgery Authors: Camargo CP, Weschenfelder RHN, Fonseca GMD, Sousa AADC, Gemperli R Tags: Acta Cir Bras Source Type: research

Use of thermography in skin grafts after the application of therapeutic ultrasound in Wistar rats.
, Moraes PC Abstract Purpose To analyze changes in the thermal pattern in the skin graft receptor bed, after the use of therapeutic ultrasound through the thermographic images. Methods Eighteen Rattus norvegicus albinus Wistar, separated into two groups: GST groups (without tumor and without treatment with ultrasound) and GT (with tumor and treatment with ultrasound). In the GT group, induction of carcinogenesis was performed by single intradermal application of 0.05 ml DMBA at 0.5%, diluted in acetone. Subsequently, a technique of reconstructive grafting surgery of the mesh type was performed in both groups and t...
Source: Acta Cirurgica Brasileira - August 21, 2020 Category: Surgery Authors: Silveira YGD, Kajiura C, Bernardes FJL, Maria SP, Fernandes MP, Frasson MT, Cassino P, Moreira SH, Gómez JLÁ, Pazzini JM, Nardi AB, Moraes PC Tags: Acta Cir Bras Source Type: research

Topical application of lidocaine or bupivacaine in the healing of surgical wounds in dogs.
CONCLUSIONS: The topical application of lidocaine and bupivacaine in the surgical wound is feasible and it does not influence skin healing. The benefit of such a practice, which has been the subject of other studies, seems to outweigh the risks. PMID: 32813774 [PubMed - in process] (Source: Acta Cirurgica Brasileira)
Source: Acta Cirurgica Brasileira - August 21, 2020 Category: Surgery Authors: Minto BW, Zanato L, Franco GG, Kawamoto FYK, Borsaro CP, Pazzini JM, Carvalho ER, Matsui A Tags: Acta Cir Bras Source Type: research

Metalloproteinases and colorectal cancer. Correlation of gene expression and clinical-pathological parameters.
Abstract PURPOSE: To analyze gene and protein expression of metalloproteinases 1, 2, 9, 11 and 16 and their correlation with clinicopathological variables in colorectal adenocarcinoma. METHODS: A retrospective study of 114 patients with colorectal adenocarcinoma treated surgically in the period 2006 to 2008 in Hospital de Câncer de Barretos - Fundação Pio XII. The evaluation of gene expression was performed by RT-PCR, and protein by immunohistochemistry. The analysis of gene expression was classified as overexpressed genes and poorly expressed (fold change of approximately 2, p
Source: Acta Cirurgica Brasileira - August 21, 2020 Category: Surgery Authors: Morini SR, Denadai MV, Waisberg J, Lopes Filho GJ, Matos D, Saad SS Tags: Acta Cir Bras Source Type: research

Erratum: Differences in lipidomics may be potential biomarkers for early diagnosis of pancreatic cancer.
Authors: PMID: 32813776 [PubMed - in process] (Source: Acta Cirurgica Brasileira)
Source: Acta Cirurgica Brasileira - August 21, 2020 Category: Surgery Tags: Acta Cir Bras Source Type: research

C-Fos expression in epileptogenic areas of nephropathic rats undergoing star fruit poisoning.
The objective of the present study was to map possible epileptogenic areas susceptible to star fruit intoxication in nephropathic rats. Methods The study analyzed 25 rats (5 groups). Rats in the experimental group underwent bilateral ureteral obstruction surgery and orogastric gavages with star fruit juice. An electroencephalogram was used to confirm convulsive seizures. Urea and creatinine levels were used to confirm the uremia model. Immunohistochemical analysis was used to map cells with c-Fos protein (c-Fos+ cells) to identify brain areas with increased neuronal activity. Control groups included non-nephropathic and ne...
Source: Acta Cirurgica Brasileira - August 15, 2020 Category: Surgery Authors: Santana RF, Silva LARD, Achar E, Ballester G, Ribeiro Junior MAF, Ortiz SRM Tags: Acta Cir Bras Source Type: research

Preconditioning with L-Ala-Gln reduces the expression of inflammatory markers (TNF- α, NF-κB, IL-6 and HO-1) in an injury animal model of cerebrovascular ischemia in Meriones unguiculatus (gerbils).
Conclusion These findings suggest a protective effect of L-Ala-Gln by decreasing levels of TNF-alpha, IL-6 and NF-κB and Increasing levels of HO-1. PMID: 32696813 [PubMed - in process] (Source: Acta Cirurgica Brasileira)
Source: Acta Cirurgica Brasileira - July 23, 2020 Category: Surgery Authors: Oliveira LRA, Albuquerque AO, Silva CISM, Silva JM, Casadevall MQFC, Azevedo OGR, Albuquerque VLSP, Vasconcelos PRL Tags: Acta Cir Bras Source Type: research

Does CO2 pneumoperitoneum in laparoscopy interfere with collagen deposition in abdominal surgical wounds?
Conclusion At 5 mmHg, CO2 pneumoperitoneum does not interfere with collagen deposition in abdominal wall surgical wounds in rats. PMID: 32667584 [PubMed - as supplied by publisher] (Source: Acta Cirurgica Brasileira)
Source: Acta Cirurgica Brasileira - July 16, 2020 Category: Surgery Authors: Morais PHA, Silva RFA, Ribeiro TDS, Farias IEC, Lino Junior RS, Carneiro FP, Durães LC, Sousa JB Tags: Acta Cir Bras Source Type: research

Pulmonary effects of ozone therapy at different doses combined with antibioticotherapy in experimental sepsis model.
Conclusion Although negative histopathological effects of ozone on tissue injury were detected, it was noteworthy that the increase in the ozone dose reduced the number of damaged parameters. PMID: 32667585 [PubMed - as supplied by publisher] (Source: Acta Cirurgica Brasileira)
Source: Acta Cirurgica Brasileira - July 16, 2020 Category: Surgery Authors: Kapicibaşi HO, Kiraz HA, Demir ET, Adali Y, Elmas S Tags: Acta Cir Bras Source Type: research

Comparative study between fructose 1-6 bisphosphate and histidine-tryptophan-ketoglutarate in liver preservation in rats submitted to total cold ischemia.
lva O Abstract Purpose To compare Fructose-1,6-Bisphosphate (FBP) to Histidine-Tryptophan-Ketoglutarate (HTK) in liver preservation at cold ischemia. Methods Male rats (Sprague-Dawley: 280-340g) divided into three groups (n=7): Control; Fructose-1,6-bisphosphate (FBP); Histidine-Tryptophan-Ketoglutarate (HTK). Animals underwent laparotomy-thoracotomy for perfusion of livers with saline. Livers were removed and deposited into solutions. Mitochondria were isolated to determine State 3 (S3), State 4 (S4), Respiratory Control Ratio (RCR) and Swelling (S). Liver enzymes (AST, ALT, LDH) were determined in solution. At t...
Source: Acta Cirurgica Brasileira - July 16, 2020 Category: Surgery Authors: Smecellato FB, Marsilli LRB, Nakamura JE, Jordani MC, Évora PRB, Castro-E-Silva O Tags: Acta Cir Bras Source Type: research

3D anatomical model for teaching canine lumbosacral epidural anesthesia.
Conclusion The use of 3DMEA demonstrated greater efficacy in the execution of the technique, being effective in the teaching and learning process before the epidural anesthesia in live animals. PMID: 32667587 [PubMed - as supplied by publisher] (Source: Acta Cirurgica Brasileira)
Source: Acta Cirurgica Brasileira - July 16, 2020 Category: Surgery Authors: Neves ECD, Pelizzari C, Oliveira RS, Kassab S, Lucas KDA, Carvalho YK Tags: Acta Cir Bras Source Type: research

A practical new strategy to prevent bile duct injury during laparoscopic cholecystectomy. A single-center experience with 5539 cases.
Conclusion The gallbladder infundibulum as a navigator is useful for ductal identification to reduce BDI and improve the safety of LC. PMID: 32667588 [PubMed - as supplied by publisher] (Source: Acta Cirurgica Brasileira)
Source: Acta Cirurgica Brasileira - July 16, 2020 Category: Surgery Authors: Shang P, Liu B, Li X, Miao J, Lv R, Guo W Tags: Acta Cir Bras Source Type: research

Quercetin associated with dimethylsulfoxide has a curative effect on experimental colon anastomosis injury.
Conclusion It was seen that quercetin speeds up the injury healing process and reveals an antioxidant effect, specifically in early period. PMID: 32667589 [PubMed - as supplied by publisher] (Source: Acta Cirurgica Brasileira)
Source: Acta Cirurgica Brasileira - July 16, 2020 Category: Surgery Authors: Demir U, Edremitlioğlu M, Kandaş E, Şehitoğlu MH, Kılınç N Tags: Acta Cir Bras Source Type: research

Safety and effectiveness of laparoscopic Y-en-Roux gastric bypass surgery in obese elderly patients.
no LK Abstract Purpose To analyze, in aged obese patients, the weight loss, comorbidity control, and safety postoperative complications of bariatric surgery by Roux-en-Y gastric bypass technique. Methods Twenty-seven patients who underwent laparoscopic weight-reducing gastroplasty with Roux-en-Y gastric bypass to treat obesity were included. All patients were ≥ 60 years old at the time of surgery. The Wilcoxon test was used for statistical analysis, and a p-value ≤0.05it was considered significant. Results Ten (90.9%) patients with dyslipidemia were cured (p
Source: Acta Cirurgica Brasileira - July 9, 2020 Category: Surgery Authors: Santos MPD, Gonçalves JE, Takahashi AAR, Britto BB, Beraldo FB, Waisberg J, Tanno LK Tags: Acta Cir Bras Source Type: research

Changrui enema inhibits inflammation-induced angiogenesis in acute radiation proctitis by regulating NF- κB and VEGF.
CONCLUSIONS: Changrui enema is an effective treatment with fewer side effects for ARP. The mechanism of Changrui enema may be related to the inhibition of inflammation-induced angiogenesis. Changrui enema inhibits IL-1β and NF-κB expression as well as VEGF expression. Interestingly, AQP1 promotes angiogenesis, while AQP3 inhibits inflammation. Changrui enema probably inhibits AQP1 expression by down-regulating p-ERK1/2, and improves AQP3 expression by up-regulating p-JNK. PMID: 32638843 [PubMed - in process] (Source: Acta Cirurgica Brasileira)
Source: Acta Cirurgica Brasileira - July 5, 2020 Category: Surgery Authors: Gao J, Li Y, Yang X, Hu M, Xu J, Cheng L, Cao K, Liu L, Wang X Tags: Acta Cir Bras Source Type: research

The influence of platelet-rich plasma (PRP) on colonic anastomosis healing impaired by intraperitoneal 5-flourouracil application. An experimental study.
In this study, we aimed to investigate the potential healing effect of platelet-rich plasma (PRP) on colonic anastomosis impaired by intraperitoneal 5-flourouracil application. METHODS: After ten rats were sacrificed for preparing PRP, forty Wistar-albino rats were subjected to colonic anastomosis, and randomly allocated into four groups including 10 rats each. According to receiving PRP and/or 5-FU application, the groups were formed as control (C), 5-FU without PRP (CT), anastomosis with PRP (C-PRP), and 5-FU with PRP (CT-PRP). CT and CT-PRP groups also received 5-FU intraperitoneally on postoperative day 1 (POD 1)....
Source: Acta Cirurgica Brasileira - July 5, 2020 Category: Surgery Authors: Gorur M, Sozutek A, Irkorucu O, Karakaya B Tags: Acta Cir Bras Source Type: research

Differences in lipidomics may be potential biomarkers for early diagnosis of pancreatic cancer.
CONCLUSION: There were lipid metabolomic differences in patients with pancreatic cancer, which could serve as potential tumor markers for pancreatic cancer. PMID: 32638847 [PubMed - in process] (Source: Acta Cirurgica Brasileira)
Source: Acta Cirurgica Brasileira - July 5, 2020 Category: Surgery Authors: Zhou D, Mu D, Cheng M, Dou Y, Zhang X, Feng Z, Qiu G, Yu H, Chen Y, Xu H, Sun J, Zhou L Tags: Acta Cir Bras Source Type: research