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Exploration of the Association between Nurses' Moral Distress and Secondary Traumatic Stress Syndrome: Implications for Patient Safety in Mental Health Services.
Abstract Work-related moral distress (MD) and secondary traumatic stress syndrome (STSS) may be associated with compromised health status among health professionals, reduced productivity, and inadequate safety of care. We explored the association of MD with the severity of STSS symptoms, along with the mediating role of mental distress symptoms. Associations with emotional exhaustion and professional satisfaction were also assessed. This cross-sectional survey conducted in 206 mental health nurses (MHNs) was employed across public sector community and hospital settings in Cyprus. The analysis revealed that MD (mea...
Source: Biomed Res - December 8, 2017 Category: Research Authors: Christodoulou-Fella M, Middleton N, Papathanassoglou EDE, Karanikola MNK Tags: Biomed Res Int Source Type: research

MYC Gene Rearrangements Are Closely Associated with Poor Survival of Diffuse Large B Cell Lymphoma with Hepatitis B Virus Infection.
In this study, 30 DLBCL patients with HBV infection and 51 DLBCL patients with HBV-free were reviewed retrospectively. As of July 2016, the median follow-up period was 26.4 months (3.0~65.0 months). The median OS of patients in HBV infection group was 38.6 months, while that of patients in HBV-free group was not reached (P = 0.042); the median progression-free survival (PFS) of patients in HBV infection group was worse than that in HBV-free group, 18.5 months and 38.5 months (P = 0.118), respectively. The rate of MYC and BCL2 gene rearrangements in HBV infection group was significantly higher than that in HBV-free group, 2...
Source: Biomed Res - December 8, 2017 Category: Research Authors: Liu Z, Li S, Guo W, Wang Y, Wang M, Bai O Tags: Biomed Res Int Source Type: research

In Vitro Antibacterial Activity of Pomegranate Juice and Peel Extracts on Cariogenic Bacteria.
Conclusions: In vitro microbiological tests demonstrate that the hydroalcoholic extracts of pomegranate juice and peel are able to contrast the main cariogenic bacteria involved in tooth decay. Although being preliminary data, our results suggest that pomegranate polyphenolic compounds could represent a good adjuvant for the prevention and treatment of dental caries. PMID: 29209624 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - December 8, 2017 Category: Research Authors: Ferrazzano GF, Scioscia E, Sateriale D, Pastore G, Colicchio R, Pagliuca C, Cantile T, Alcidi B, Coda M, Ingenito A, Scaglione E, Cicatiello AG, Volpe MG, Di Stasio M, Salvatore P, Pagliarulo C Tags: Biomed Res Int Source Type: research

Prediction and Validation of Hub Genes Associated with Colorectal Cancer by Integrating PPI Network and Gene Expression Data.
In conclusion, the four hub genes screened by our strategy could serve as novel biomarkers for prognosis prediction of CRC patients. PMID: 29209625 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - December 8, 2017 Category: Research Authors: Xiong Y, You W, Wang R, Peng L, Fu Z Tags: Biomed Res Int Source Type: research

Neovascular Prostate-Specific Membrane Antigen Expression Is Associated with Improved Overall Survival under Palliative Chemotherapy in Patients with Pancreatic Ductal Adenocarcinoma.
Huss S Abstract Aims: Expression of PSMA (prostate-specific membrane antigen) has been demonstrated in various cancers, including pancreatic ductal adenocarcinoma (PDAC). However, PSMA expression in PDAC-associated neovasculature has so far not been systematically analyzed. Methods and Results: We analyzed PSMA expression in 81 PDAC tissue samples from 61 patients. Microvessel density (MVD) was assessed by software-based image analysis and showed a mean MVD of 63.7 microvessels/0.785 mm2. PSMA was practically absent in tumor tissue (5.3%) and PDAC cell lines (0/7) but could be detected i...
Source: Biomed Res - December 8, 2017 Category: Research Authors: Stock K, Steinestel K, Wiesch R, Mikesch JH, Hansmeier A, Trautmann M, Beller N, Rehkämper J, Wardelmann E, Heitkötter B, Hartmann W, Sperveslage J, Huss S Tags: Biomed Res Int Source Type: research

Thermosensitive Chitosan Hydrogels Containing Polymeric Microspheres for Vaginal Drug Delivery.
Abstract Thermosensitive hydrogels have increasingly received considerable attention for local drug delivery based on many advantages. However, burst release of drugs is becoming a critical challenge when the hydrogels are employed. Microspheres- (MS-) loaded thermosensitive hydrogels were thus fabricated to address this limitation. Employing an orthogonal design, the spray-dried operations of tenofovir (TFV)/Bletilla striata polysaccharide (BSP)/chitosan (CTS) MS were optimized according to the drug loading (DL). The physicochemical properties of the optimal MS (MS F) were characterized. Depending on the gelation...
Source: Biomed Res - December 8, 2017 Category: Research Authors: Yang TT, Cheng YZ, Qin M, Wang YH, Yu HL, Wang AL, Zhang WF Tags: Biomed Res Int Source Type: research

Inhibitors of Histone Deacetylases Are Weak Activators of the FMR1 Gene in Fragile X Syndrome Cell Lines.
Abstract Fragile X syndrome is the most common cause of inherited intellectual disability in humans. It is a result of CGG repeat expansion in the 5' untranslated region (5' UTR) of the FMR1 gene. This gene encodes the FMRP protein that is involved in neuronal development. Repeat expansion leads to heterochromatinization of the promoter, gene silencing, and the subsequent absence of FMRP. To date, there is no specific therapy for the syndrome. All treatments in clinic practice provide symptomatic therapy. The development of drug therapy for Fragile X syndrome treatment is connected with the search for inhibitors o...
Source: Biomed Res - December 8, 2017 Category: Research Authors: Dolskiy AA, Pustylnyak VO, Yarushkin AA, Lemskaya NA, Yudkin DV Tags: Biomed Res Int Source Type: research

Corrigendum to "Effects of Chronic Exposure to Sodium Arsenite on Expressions of VEGF and VEGFR2 Proteins in the Epididymis of Rats".
Corrigendum to "Effects of Chronic Exposure to Sodium Arsenite on Expressions of VEGF and VEGFR2 Proteins in the Epididymis of Rats". Biomed Res Int. 2017;2017:4284156 Authors: Yan-Ping D, Xiao-Qin G, Xiao Ping M, Ying Quan Y Abstract [This corrects the article DOI: 10.1155/2017/2597256.]. PMID: 29209629 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - December 8, 2017 Category: Research Authors: Yan-Ping D, Xiao-Qin G, Xiao Ping M, Ying Quan Y Tags: Biomed Res Int Source Type: research

Barriers to Physical Activity in Low Back Pain Patients following Rehabilitation: A Secondary Analysis of a Randomized Controlled Trial.
Conclusions: Low back pain patients especially with a low level of education and fear of pain seem to need tailored support in overcoming barriers to physical activity. This study is registered at German Clinical Trials Register (DRKS00004878). PMID: 29209630 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - December 8, 2017 Category: Research Authors: Schaller A, Exner AK, Schroeer S, Kleineke V, Sauzet O Tags: Biomed Res Int Source Type: research

Maxillary Sinus Floor Augmentation Using an Equine-Derived Graft Material: Preliminary Results in 17 Patients.
Conclusion: Within the limitations of this study, this equine-derived bone graft proved to be an effective material to induce new bone formation in the sinus floor elevation procedure. PMID: 29209631 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - December 8, 2017 Category: Research Authors: Rivara F, Negri M, Lumetti S, Parisi L, Toffoli A, Calciolari E, Manfredi E, Macaluso GM Tags: Biomed Res Int Source Type: research

Quality of Care during Neonatal Resuscitation in Kakamega County General Hospital, Kenya: A Direct Observation Study.
Conclusion: Key steps in NR are poorly performed during drying and warmth, airway maintenance in meconium presence, and ventilation. Mentorship with periodic refresher training can improve the care provided during NR. PMID: 29214159 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - December 8, 2017 Category: Research Authors: Shikuku DN, Milimo B, Ayebare E, Gisore P, Nalwadda G Tags: Biomed Res Int Source Type: research

miR-217 Is a Useful Diagnostic Biomarker and Regulates Human Podocyte Cells Apoptosis via Targeting TNFSF11 in Membranous Nephropathy.
In this study, we investigated whether miR-217 is a useful diagnostic biomarker and the possible pathological mechanism of miR-217 in this disease. Methods: Patients with focal segmental glomerulosclerosis (FSGS), membranous nephropathy (MN), and diabetic nephropathy (DN) and control patients were enrolled in this study. The miR-217 inhibitor and mimics were transfected into human podocyte cells to investigate the pathological mechanism of miR-217 in this disease. Relevant indicators were detected and tested. Results: Compared with control patients, miR-217 was significantly downregulated and TNFSF11 was signific...
Source: Biomed Res - December 8, 2017 Category: Research Authors: Li J, Liu B, Xue H, Zhou QQ, Peng L Tags: Biomed Res Int Source Type: research

Brain Computer Interface Systems for Neurorobotics: Methods and Applications.
o PPR PMID: 29214161 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - December 8, 2017 Category: Research Authors: de Albuquerque VHC, Damaševičius R, Garcia NM, Pinheiro PR, Filho PPR Tags: Biomed Res Int Source Type: research

Current Tissue Molecular Markers in Colorectal Cancer: A Literature Review.
Conclusion: Biomarkers can become an important tool in the diagnostic and therapeutic process for CRC. But further studies are needed to identify a noninvasive, cost-effective, and highly sensible and specific screening test for their detection and to standardize their use in clinical practice. PMID: 29214162 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - December 8, 2017 Category: Research Authors: Peluso G, Incollingo P, Calogero A, Tammaro V, Rupealta N, Chiacchio G, Sandoval Sotelo ML, Minieri G, Pisani A, Riccio E, Sabbatini M, Bracale UM, Dodaro CA, Carlomagno N Tags: Biomed Res Int Source Type: research

Protective Effects of Pyridoxamine Supplementation in the Early Stages of Diet-Induced Kidney Dysfunction.
Abstract Pyridoxamine, a structural analog of vitamin B6 that exerts antiglycative effects, has been proposed as supplementary approach in patients with initial diabetic nephropathy. However, the molecular mechanism(s) underlying its protective role has been so far slightly examined. C57Bl/6J mice were fed with a standard diet (SD) or a diet enriched in fat and fructose (HD) for 12 weeks. After 3 weeks, two subgroups of SD and HD mice started pyridoxamine supplementation (150 mg/kg/day) in the drinking water. HD fed mice showed increased body weight and impaired glucose tolerance, whereas pyridoxamine admin...
Source: Biomed Res - December 8, 2017 Category: Research Authors: Chiazza F, Cento AS, Collotta D, Nigro D, Rosa G, Baratta F, Bitonto V, Cutrin JC, Aragno M, Mastrocola R, Collino M Tags: Biomed Res Int Source Type: research

Outcome of Critically Ill Patients with Testicular Cancer.
ía P, González-Chon O, Herrera-Gómez A Abstract Purpose: To evaluate the clinical characteristics and outcomes of critically ill patients with testicular cancer (TC) admitted to an oncological intensive care unit (ICU). Methods: This was a prospective observational study. There were no interventions. Results: During the study period, 1,402 patients with TC were admitted to the Department of Oncology, and 60 patients (4.3%) were admitted to the ICU. The most common histologic type was nonseminomatous germ cell tumors (55/91.7%). The ICU, hospital, and 6-month mortality rates were 38.3...
Source: Biomed Res - December 8, 2017 Category: Research Authors: Ñamendys-Silva SA, Barragán-Dessavre M, Bautista-Ocampo AR, García-Guillén FJ, Córdova-Sánchez BM, Constantino-Hérnandez E, Correa-García P, González-Chon O, Herrera-Gómez A Tags: Biomed Res Int Source Type: research

Safety Assessment and Comparison of Sodium Selenite and Bioselenium Obtained from Yeast in Mice.
Abstract Detailed safety assessment of sodium selenite and bioselenium (bio-Se) was conducted and the results were compared and discussed for the purpose of assessing safety of bio-Se for use in food applications. In this work, acute toxicity studies, micronucleus test, and sperm aberration study in mice, 30-day feeding test of mice, were conducted to evaluate the toxicity of bio-Se obtained from yeast with different fermentation time (transformative time: one month, three months, and six months), and the results were compared with that of inorganic Se (sodium selenite). LD50 of sodium selenite was calculated to b...
Source: Biomed Res - December 8, 2017 Category: Research Authors: Wang X, Yang Y, Zhang H, Liu J Tags: Biomed Res Int Source Type: research

miRNAs: Important Targets for Oral Cancer Pain Research.
Abstract Pain is a symptom shared by an incredible number of diseases. It is also one of the primary conditions that prompt individuals to seek medical treatment. Head and neck squamous cell carcinoma (HNSCC) corresponds to a heterogeneous disease that may arise from many distinct structures of a large, highly complex, and intricate region. HNSCC affects a great number of patients worldwide and is directly associated with chronic pain, which is especially prominent during the advanced stages of oral squamous cell carcinoma (OSCC), an anatomical and clinical subtype that corresponds to the great majority oral cance...
Source: Biomed Res - December 8, 2017 Category: Research Authors: Pereira CM, Sehnem D, da Fonseca EO, Barboza HFG, de Carvalho ACP, DaSilva AFM, Moura-Neto V, DosSantos MF Tags: Biomed Res Int Source Type: research

Comparison of US Strain Elastography and Entero-MRI to Typify the Mesenteric and Bowel Wall Changes during Crohn's Disease: A Pilot Study.
Conclusions: US-SE, ADC, and signal intensity on T2-weighted sequences on MR prove to be useful tools for the evaluation of CD pattern. PMID: 29214167 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - December 8, 2017 Category: Research Authors: Lo Re G, Picone D, Vernuccio F, Scopelliti L, Di Piazza A, Tudisca C, Serraino S, Privitera G, Midiri F, Salerno S, Midiri M, Bartolotta TV, Lagalla R Tags: Biomed Res Int Source Type: research

How Well Can Modern Nonhabitual Barefoot Youth Adapt to Barefoot and Minimalist Barefoot Technology Shoe Walking, in regard to Gait Symmetry.
Abstract We aim to test how well modern nonhabitual barefoot people can adapt to barefoot and Minimalist Bare Foot Technology (MBFT) shoes, in regard to gait symmetry. 28 healthy university students (22 females/6 males) were recruited to walk on a 10-meter walkway randomly on barefoot, in MBFT shoes, and in neutral running shoes at their comfortable walking speed. Kinetic and kinematic data were collected using an 8-camera motion capture system. Data of joint angles, joint forces, and joint moments were extracted to compute a consecutive symmetry index. Compared to walking in neutral running shoes, walking barefoo...
Source: Biomed Res - December 8, 2017 Category: Research Authors: Xu Y, Hou Q, Wang C, Simpson T, Bennett B, Russell S Tags: Biomed Res Int Source Type: research

Reversal of Proximal Renal Tubular Dysfunction after Nucleotide Analogue Withdrawal in Chronic Hepatitis B.
Conclusion: One year after nucleotide analogue withdrawal, PRTD was resolved in most patients. Changes in TmPO4/GFR, urinary protein, and β2-microglobulin indicate that urinary biomarkers may represent an early sign of PRTD recovery. PMID: 29214169 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - December 8, 2017 Category: Research Authors: Sobhonslidsuk A, Numthavaj P, Wanichanuwat J, Sophonsritsuk A, Petraksa S, Pugasub A, Jittorntam P, Kongsomgan A, Roytrakul S, Phakdeekitcharoen B Tags: Biomed Res Int Source Type: research

NLRP1 Overexpression Is Correlated with the Tumorigenesis and Proliferation of Human Breast Tumor.
Abstract Recent studies suggest that nucleotide-binding domain leucine-rich repeat protein 1 (NLRP1) is a pivotal factor in the inflammatory process. However, the role of NLRP1 in breast cancer pathogenesis remains unclear. The aim of this study was to examine the expression and function of NLRP1 in breast cancer. We found that NLRP1 was widely expressed in 83% (60/72) of primary breast cancer tissue. NLRP1 expression level was higher in primary breast cancer tissue than in adjacent noncancerous tissue (p
Source: Biomed Res - December 8, 2017 Category: Research Authors: Wei Y, Huang H, Qiu Z, Li H, Tan J, Ren G, Wang X Tags: Biomed Res Int Source Type: research

Evaluating Swine Injection Technologies as a Workplace Musculoskeletal Injury Intervention: A Study Protocol.
Abstract Intensification of modern swine production has led to many new technologies, including needleless injectors. Although needleless injectors may increase productivity (by reducing injection time) and reduce needlestick injuries, the effect on risk for musculoskeletal disorders is not clear. This project will compare conventional needles with needleless injectors in terms of cost, productivity, injury rates, biomechanical exposures, and worker preference. Muscle activity (EMG) and hand/wrist posture will be measured on swine workers performing injection tasks with both injection methods. Video recordings dur...
Source: Biomed Res - December 8, 2017 Category: Research Authors: Trask C, Bath B, Milosavljevic S, Kociolek AM, Predicala B, Penz E, Adebayo O, Whittington L Tags: Biomed Res Int Source Type: research

Migraine and Complex Regional Pain Syndrome: A Case-Referent Clinical Study.
Abstract We studied clinical phenotype differences between migraineurs with CRPS (Mig + CRPS) and those without (Mig - CRPS). Mig + CRPS cases and Mig - CRPS referents aged ≥18 years were enrolled. Diagnosis was made in accordance with International Classification of Headache Disorders-3 beta (ICHD-3 beta) for migraine and Budapest Criteria for CRPS. Migraines both with and without aura were included. A total of 70 Mig + CRPS cases (13% males, mean age 48 years) and 80 Mig - CRPS referents (17% males, mean age 51 years) were included. 33% of Mig + CRPS and 38% of Mig - CRPS exhibited episodic migraine (EM) whil...
Source: Biomed Res - December 8, 2017 Category: Research Authors: Woldeamanuel YW, Cooley C, Foley-Saldena K, Cowan RP Tags: Biomed Res Int Source Type: research

Fabrication and In Vitro Study of Tissue-Engineered Cartilage Scaffold Derived from Wharton's Jelly Extracellular Matrix.
In conclusion, these results suggest that a WJECM scaffold may be favorable for future cartilage tissue engineering. PMID: 29214173 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - December 8, 2017 Category: Research Authors: Xiao T, Guo W, Chen M, Hao C, Gao S, Huang J, Yuan Z, Zhang Y, Wang M, Li P, Peng J, Wang A, Wang Y, Sui X, Zhang L, Xu W, Lu S, Yin H, Yang J, Liu S, Guo Q Tags: Biomed Res Int Source Type: research

Feasibility of Round Window Stimulation by a Novel Electromagnetic Microactuator.
Conclusion: The feasibility of an electromagnetic actuator that may be placed into the RW niche was demonstrated but requires further optimization in terms of THD and static force sensitivity. PMID: 29214174 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - December 8, 2017 Category: Research Authors: van Drunen WJ, Mueller M, Glukhovskoy A, Salcher R, Wurz MC, Lenarz T, Maier H Tags: Biomed Res Int Source Type: research

What Healthcare Workers Should Know about Environmental Bacterial Contamination in the Intensive Care Unit.
Abstract Intensive care unit- (ICU-) acquired infections are a major health problem worldwide. Inanimate surfaces and equipment contamination may play a role in cross-transmission of pathogens and subsequent patient colonization or infection. Bacteria contaminate inanimate surfaces and equipment of the patient zone and healthcare area, generating a reservoir of potential pathogens, including multidrug resistant species. Traditional terminal cleaning methods have limitations. Indeed patients who receive a bed from prior patient carrying bacteria are exposed to an increased risk (odds ratio 2.13, 95% confidence inte...
Source: Biomed Res - December 8, 2017 Category: Research Authors: Russotto V, Cortegiani A, Fasciana T, Iozzo P, Raineri SM, Gregoretti C, Giammanco A, Giarratano A Tags: Biomed Res Int Source Type: research

Human Gut Microbiota Associated with Obesity in Chinese Children and Adolescents.
Conclusion: Our results might enrich the research between gut microbiota and obesity and further provide a clinical basis for therapy for obesity. We recommend that Bifidobacterium and Lactobacillus might be used as indicators of healthy conditions among obese children, as well as a kind of prebiotic and probiotic supplement in the diet to be an auxiliary treatment for obesity. PMID: 29214176 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - December 8, 2017 Category: Research Authors: Hou YP, He QQ, Ouyang HM, Peng HS, Wang Q, Li J, Lv XF, Zheng YN, Li SC, Liu HL, Yin AH Tags: Biomed Res Int Source Type: research

Linked Registries: Connecting Rare Diseases Patient Registries through a Semantic Web Layer.
obinson P, Roos M, Oliveira JL Abstract Patient registries are an essential tool to increase current knowledge regarding rare diseases. Understanding these data is a vital step to improve patient treatments and to create the most adequate tools for personalized medicine. However, the growing number of disease-specific patient registries brings also new technical challenges. Usually, these systems are developed as closed data silos, with independent formats and models, lacking comprehensive mechanisms to enable data sharing. To tackle these challenges, we developed a Semantic Web based solution that allows connecti...
Source: Biomed Res - December 8, 2017 Category: Research Authors: Sernadela P, González-Castro L, Carta C, van der Horst E, Lopes P, Kaliyaperumal R, Thompson M, Thompson R, Queralt-Rosinach N, Lopez E, Wood L, Robertson A, Lamanna C, Gilling M, Orth M, Merino-Martinez R, Posada M, Taruscio D, Lochmüller H, Robinson P Tags: Biomed Res Int Source Type: research

Serum miRNAs miR-23a, 206, and 499 as Potential Biomarkers for Skeletal Muscle Atrophy.
In conclusion, our results demonstrated that circulating miRNAs could serve as useful biochemical and molecular indicators for muscle atrophy diagnosis and disease progression. PMID: 29214178 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - December 8, 2017 Category: Research Authors: Wang F, Wang J, He J, Li W, Li J, Chen S, Zhang P, Liu H, Chen X Tags: Biomed Res Int Source Type: research

The Roles of Thrombospondins in Hemorrhagic Stroke.
Abstract Hemorrhagic stroke is a devastating cerebrovascular disease with significant morbidity and mortality worldwide. Thrombospondins (TSPs), as matricellular proteins, belong to the TSP family which is comprised of five members. All TSPs modulate a variety of cellular functions by binding to various receptors. Recently, TSPs gained attention in the area of hemorrhagic stroke, especially TSP-1. TSP-1 participates in angiogenesis, the inflammatory response, apoptosis, and fibrosis after hemorrhagic stroke through binding to various molecules including but not limited to CD36, CD47, and TGF-β. In this review...
Source: Biomed Res - December 8, 2017 Category: Research Authors: Wu X, Luo X, Zhu Q, Zhang J, Liu Y, Luo H, Cheng Y, Xie Z Tags: Biomed Res Int Source Type: research

Circulating MicroRNA Profiles Differ between Hyperglycemia and Euglycemia in Coronary Heart Disease Patients.
Abstract Coronary heart disease (CHD) has become one of the leading causes of death and functional impairment in the world. Hyperglycemia is associated with an increased risk of cardiovascular disease. It was speculated that miRNAs in peripheral blood were a primary parameter in discriminating CHD. The biological characteristics of coronary heart disease with hyperglycemia (HCHD) and coronary heart disease with euglycemia (ECHD) were investigated in the study. Circulating miRNAs from 26 HCHD patients and 42 ECHD patients were identified by microarrays. Compared with the healthy patients, 15 and 20 differentially e...
Source: Biomed Res - December 8, 2017 Category: Research Authors: Jiang Y, Liu N, Xue B, Hou J, Lin C, Ren J, Liu J Tags: Biomed Res Int Source Type: research

Reference Values of Flexion and Supination in the Elbow Joint of a Cohort without Shoulder Pathologies.
l;ller MJ, Müller PE Abstract Background: After surgery of the long head of the biceps tendon, the examination of the biceps brachii muscle function and strength is common clinical practice. The muscle strength is usually compared with the uninjured contralateral side or with a matched pair group assuming that the uninjured side can be used as an appropriate reference. Hypothesis/Purpose: The purpose of this study was to define reference values of the supination and flexion strength in the elbow joint and to investigate the influence of the arm positions and various anthropometric factors. Methods: ...
Source: Biomed Res - December 7, 2017 Category: Research Authors: Güleçyüz MF, Pietschmann MF, Michalski S, Eberhard FM, Crispin A, Schröder C, Mittermüller MJ, Müller PE Tags: Biomed Res Int Source Type: research

Endovascular Treatment for Acute Thromboembolic Occlusion of the Superior Mesenteric Artery and the Outcome Comparison between Endovascular and Open Surgical Treatments: A Retrospective Study.
We reported our experience with endovascular treatment for patients with acute thromboembolic occlusion of the superior mesenteric artery (ATOS) as well as comparing the efficacy between endovascular and traditional open surgical treatments. Eighteen consecutive patients with ATOS who received endovascular treatment and 12 patients who received open surgical treatment between February 2007 and October 2012 at Tianjin Union Medical Center (Tianjin, China) were retrospectively reviewed. Primary clinical outcomes included the technical success, requirement of laparotomy, length of bowel resection, perioperative mortality with...
Source: Biomed Res - December 7, 2017 Category: Research Authors: Zhang Z, Wang D, Li G, Wang X, Wang Y, Li G, Jiang T Tags: Biomed Res Int Source Type: research

The Immunomodulatory Imbalance in Patients with Ketamine Cystitis.
Abstract The pathogenesis of ketamine cystitis (KC) has been recently linked with immune response to patients but the same has not yet been established. Hence, this study aims to propose a possible immune mechanism of irreversible bladder damage caused by KC. A total of 53 KC patients and 21 healthy volunteers as controls have been retrospectively assessed. The levels of serum immunoglobulin E (IgE), IL-6, and IFN-γ of KC patients were significantly higher than those of controls, whereas the TGF-β levels of KC patients substantially reduced but the IL-2 and IL-4 levels of KC patients were comparable to ...
Source: Biomed Res - December 7, 2017 Category: Research Authors: Fan GY, Cherng JH, Chang SJ, Poongodi R, Chang A, Wu ST, Meng E Tags: Biomed Res Int Source Type: research

Functional Activation-Informed Structural Changes during Stroke Recovery: A Longitudinal MRI Study.
Conclusion: This study demonstrated that combining the stroke-induced functional reorganization and structural change provided new insights into the underlying innate plasticity process during stroke recovery. Significance: This study proposed a new approach to integrate functional and structural information for investigating the innate plasticity after stroke. PMID: 29204440 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - December 7, 2017 Category: Research Authors: Wu Z, Cheng L, Yang GY, Tong S, Sun J, Miao F Tags: Biomed Res Int Source Type: research

Preemptive Analgesic and Antioxidative Effect of Curcumin for Experimental Migraine.
AC Abstract Objective: Our study aimed to investigate the analgesic and antioxidative stress effects of Curcumin (CC) in experimental migraine induced by Nitroglycerin (NTG) on rats, compared with Indomethacin (ID) and Propranolol (PP) treatments. Material and Methods: Five groups of 10 rats treated i.p. were investigated: control group (healthy rats) injected with saline solution (0.9%), NTG-control group injected with NTG (1 mg/100 gbw, bw = body weight), and three groups with pretreatment applied 30 min previous to the formalin test (NTG + CC group: Curcumin (10 mg/100 ...
Source: Biomed Res - December 7, 2017 Category: Research Authors: Bulboacă AE, Bolboacă SD, Stănescu IC, Sfrângeu CA, Bulboacă AC Tags: Biomed Res Int Source Type: research

In Vitro Screening of Three Indian Medicinal Plants for Their Phytochemicals, Anticholinesterase, Antiglucosidase, Antioxidant, and Neuroprotective Effects.
In conclusion, A. alnifolia, P. indica, and O. obtusata could be promising sources for the treatment of AD and DM since these fractions induced significant anticholinesterase, antidiabetic, antioxidant, and neuroprotection effects attributable to phenolic, flavonoid, and terpenoid contents and encourage further studies for development of multifunctional therapeutic agent for AD and DM dual therapy. PMID: 29204442 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - December 7, 2017 Category: Research Authors: Penumala M, Zinka RB, Shaik JB, Amooru Gangaiah D Tags: Biomed Res Int Source Type: research

Dissatisfaction in Child Welfare and Its Role in Predicting Self-Efficacy and Satisfaction at Work: A Mixed-Method Research.
Abstract Child welfare organizations are increasingly concerned with challenges emerging from the assessment of social workers' dissatisfaction. This type of service represents the work area where social workers are at greater risk of burnout. Although several studies account for high social workers' burnout scores, they do not systematically dwell upon its sources and roots. In addition, scholars point out that a considerable number of work related issues may be perceived both as a source of dissatisfaction and satisfaction. We assume that there is a need to deepen the understanding of how dissatisfaction's sourc...
Source: Biomed Res - December 7, 2017 Category: Research Authors: Berlanda S, Pedrazza M, Trifiletti E, Fraizzoli M Tags: Biomed Res Int Source Type: research

The Finite Element Simulation of the Upper Airway of Patients with Moderate and Severe Obstructive Sleep Apnea Hypopnea Syndrome.
Conclusions: We were able to observe the vibrations of soft tissue and the modeled airflow by applying the finite element methods. Future studies could focus on improving the soft tissues vibration compliances by adjusting the model parameters. Additionally, more attention should be paid to vibrational components below 20 Hz when performing an acoustic analysis of human snore sounds due to the presence of these frequencies in this model. PMID: 29204444 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - December 7, 2017 Category: Research Authors: Luo H, Scholp A, Jiang JJ Tags: Biomed Res Int Source Type: research

Dental Implant Surrounding Marginal Bone Level Evaluation: Platform Switching versus Platform Matching-One-Year Retrospective Study.
Abstract The benefits and feasibility of platform switching have been discussed in several studies, reporting lesser crestal bone loss in platform-switched implants than in platform-matched implants. Objective. The aim of the present study was to observe the changes in vertical and horizontal marginal bone levels in platform-switched and platform-matched dental implants. Materials and Methods. 51 patients received 60 dental implants in the present study over a 1-year period. Measurement was performed between the implant shoulder and the most apical and horizontal marginal defect by periapical radiographs to examin...
Source: Biomed Res - December 7, 2017 Category: Research Authors: Salamanca E, Lin JC, Tsai CY, Hsu YS, Huang HM, Teng NC, Wang PD, Feng SW, Chen MS, Chang WJ Tags: Biomed Res Int Source Type: research

miR-195-5p Suppresses the Proliferation, Migration, and Invasion of Oral Squamous Cell Carcinoma by Targeting TRIM14.
Abstract MicroRNAs (miRNAs) play an essential role in tumor biological processes through interacting with specific gene targets. The involvement of miR-195-5p in cell proliferation, invasion, and migration has been demonstrated in several cancer cell lines, while its function in oral squamous cell carcinoma (OSCC) remains unclear. Here we find that miR-195-5p expression is lower in OSCC than in nontumor tissues, while its overexpression in cell lines can lead to the promotion of apoptosis and the reduction of cell growth, migration, and invasion. Moreover, we identify the tripartite motif-containing protein (TRIM1...
Source: Biomed Res - December 7, 2017 Category: Research Authors: Wang T, Ren Y, Liu R, Ma J, Shi Y, Zhang L, Bu R Tags: Biomed Res Int Source Type: research

Effects of LncRNA BC168687 siRNA on Diabetic Neuropathic Pain Mediated by P2X7 Receptor on SGCs in DRG of Rats.
In conclusion, lncRNA BC168687 may participate in the pathogenesis of DNP mediated by P2X7 receptor, which will provide a novel way for the study of the pathogenesis of diabetes mellitus complicated with neuropathic pain and its prevention and treatment. PMID: 29204447 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - December 7, 2017 Category: Research Authors: Liu C, Tao J, Wu H, Yang Y, Chen Q, Deng Z, Liu J, Xu C Tags: Biomed Res Int Source Type: research

Punctaporonins N-S, New Caryophyllene Sesquiterpenoids from Cytospora sp.
Abstract Six new caryophyllene sesquiterpenoids, punctaporonins N-S (1-6), and three known ones, 6-hydroxypunctaporonins B (7), A (8), and E (9), have been isolated from solid cultures of Cytospora sp. The structures of 1-6 were elucidated primarily by NMR spectroscopy. The absolute configuration of 1 was assigned by X-ray crystallographic analysis of its S-MTPA ester. Compounds 2, 5, and 6 showed modest cytotoxicity against HeLa cells. PMID: 29204448 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - December 7, 2017 Category: Research Authors: Li Y, Wang Q, Liu X, Che Y Tags: Biomed Res Int Source Type: research

Combined Transcriptomic Analysis Revealed AKR1B10 Played an Important Role in Psoriasis through the Dysregulated Lipid Pathway and Overproliferation of Keratinocyte.
In this study, we integrated different psoriasis RNA-seq datasets to reveal the pathogenesis of psoriasis through the analysis of differentially expressed genes (DEGs), pathway analysis, and functional annotation. The revealed biomarkers were further validated through proliferation phenotypes. The results showed that DEGs were functionally related to lipid metabolism and keratinocyte differentiation dysregulation. The results also showed new biomarkers, such as AKR1B10 and PLA2G gene families, as well as pathways that include the PPAR signaling pathway, cytokine-cytokine receptor interaction, alpha-linoleic acid metabolism...
Source: Biomed Res - December 7, 2017 Category: Research Authors: Gao Y, Yi X, Ding Y Tags: Biomed Res Int Source Type: research

Exploring the Urtica dioica Leaves Hemostatic and Wound-Healing Potential.
Abstract The present paper investigated the efficiency of Urtica dioica (U. dioica) on hemostatic and wound healing activities. U. dioica leaf extracts were evaluated for their antibacterial and antioxidant effects as well as their flavonoid and polyphenol content. The hydroethanolic extract (EtOH-H2OE), showing the most potent antibacterial and antioxidant activities in vitro, thanks to its flavonoid and polyphenol richness, was selected for hemostatic and wound healing evaluation. Twenty-four rats completing full-thickness wounds were split into four groups. The wounds were topically treated with saline solution...
Source: Biomed Res - December 5, 2017 Category: Research Authors: Zouari Bouassida K, Bardaa S, Khimiri M, Rebaii T, Tounsi S, Jlaiel L, Trigui M Tags: Biomed Res Int Source Type: research

Effect of Glycine, Pyruvate, and Resveratrol on the Regeneration Process of Postischemic Intestinal Mucosa.
Conclusion: While glycine could improve in part regeneration but not proliferation, sodium pyruvate seems to be a possible therapeutic agent to facilitate proliferation and to support mucosal regeneration after I/R injury to the small intestine. PMID: 29201896 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - December 5, 2017 Category: Research Authors: Brencher L, Petrat F, Stych K, Hamburger T, Kirsch M Tags: Biomed Res Int Source Type: research

Combined Treatment with an Anticoagulant and a Vasodilator Prevents Steroid-Associated Osteonecrosis of Rabbit Femoral Heads by Improving Hypercoagulability.
In conclusion, the combined prevention with an anticoagulant and a vasodilator has the potential to decrease the incidence of steroid-associated ONFH in rabbits. PMID: 29201897 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - December 5, 2017 Category: Research Authors: Cao F, Liu G, Wang W, Wang B, Wei X, Lu F, Yang F, Kang K, Wang Y, Yang J, Qin K, Zhao D Tags: Biomed Res Int Source Type: research

Small Molecule Supplements Improve Cultured Megakaryocyte Polyploidization by Modulating Multiple Cell Cycle Regulators.
In this study, to gain a better PLTs production, four small molecules (Rho-Rock inhibitor (RRI), nicotinamide (NIC), Src inhibitor (SI), and Aurora B inhibitor (ABI)) and their combinations were surveyed as MK culture supplements for promoting polyploidization. Three leukemia cell lines as well as primary mononuclear cells were chosen in the function and mechanism studies of the small molecules. In an optimal culture method, cells were treated with different small molecules and their combinations. The impact of the small molecules on megakaryocytic surface marker expression, polyploidy, proliferation, and apoptosis was exa...
Source: Biomed Res - December 5, 2017 Category: Research Authors: Zou X, Qu M, Fang F, Fan Z, Chen L, Yue W, Xie X, Pei X Tags: Biomed Res Int Source Type: research

Cephalometric Soft Tissue Characteristics of Unilateral Cleft Lip and Palate Patients in Relation to Missing Teeth.
Conclusion: In subjects with a UCCLP anomaly, missing teeth have an effect on lower lip position and length, which influenced the mentolabial sulcus. Lower lip position and length differ between cleft patients who present with either multiple missing teeth or with no missing teeth, and this needs to be considered during orthodontic treatment planning and surgical management for the cleft defect. PMID: 29201899 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - December 5, 2017 Category: Research Authors: Almoammar KA, Almarhoon HA, Batwa W, Alqahtani N, Al-Jewair T, Albarakati S Tags: Biomed Res Int Source Type: research