TMT-Based Quantitative Proteomic Analysis Identification of Integrin Alpha 3 and Integrin Alpha 5 as Novel Biomarkers in Pathogenesis of Acute Aortic Dissection.
This study is aimed at identifying the differential abundance proteins (DAPs) of aortic arch tissues in patients with AAD by proteomics and select possible proteins involved in AAD pathogenesis. Methods: The fresh aortic arch tissues obtained from 5 AAD patients and 1 healthy donor were analyzed by amine-reactive tandem mass tag (TMT) labelling and mass spectrometry; then, the pathological sections of another 10 healthy donors and 20 AAD patients were chosen to verify the proteomic results by immunohistochemistry. Results: Of 809 proteins identified by proteomic analysis, 132 differential abundance proteins (DAPs...
Source: Biomed Res - August 29, 2020 Category: Research Authors: Xing L, Xue Y, Yang Y, Wu P, Wong CCL, Wang H, Song Z, Shi D, Tong C, Yao C, Gu G Tags: Biomed Res Int Source Type: research

Inhibition of Specificity Protein 1 Is Involved in Phloretin-Induced Suppression of Prostate Cancer.
Abstract Phloretin is a flavonoid existed in various plants and has been reported to possess anticarcinogenic activity. However, the anticancer mechanism of phloretin in prostate cancer (PCa) remains unclear. Here, our in vitro and in vivo experimental data demonstrate that phloretin inhibits the phosphorylation and the activation of EGFR and then inhibits its downstream PI3K/AKT and MEK/ERK1/2 pathways in PCa cells. Inhibition of these two pathways further decreases expression of Sp1 by inhibiting Sp1 gene transcription, induces degradation of Sp1 protein by inhibiting GSK3β phosphorylation, suppresses nucle...
Source: Biomed Res - August 29, 2020 Category: Research Authors: Kang D, Zuo W, Wu Q, Zhu Q, Liu P Tags: Biomed Res Int Source Type: research

Immune-Related lncRNA Risk Signatures Predict Survival of IDH Wild-Type and MGMT Promoter Unmethylated Glioblastoma.
Conclusion: There are limited studies about immune regulation mechanisms of lncRNA in IDH wild-type with MGMT promoter unmethylated glioblastoma. The identified immune-related lncRNAs in glioblastoma might contribute new targets and research directions for immunological molecular studies of glioblastoma. PMID: 32851059 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - August 29, 2020 Category: Research Authors: Li X, Meng Y Tags: Biomed Res Int Source Type: research

Improving Physical Fitness of Children with Intellectual and Developmental Disabilities through an Adapted Rhythmic Gymnastics Program in China.
Abstract Background: Health-related physical fitness is vital for children with intellectual and developmental disabilities (IDD) to gain healthier lives. The adapted rhythmic gymnastics (ARG) program was designed for children with IDD and is aimed at testing the effects of the exercise program on children's physical fitness. Methods: Participants were recruited from two special needs schools in Beijing of China. Twenty-two children with IDD were assigned to an ARG experimental group or a traditional control group. The experimental group took part in a 16-week ARG program consisting of three 50 min ses...
Source: Biomed Res - August 29, 2020 Category: Research Authors: Xu C, Yao M, Kang M, Duan G Tags: Biomed Res Int Source Type: research

The Novel Coronavirus Disease (COVID-19): A PRISMA Systematic Review and Meta-Analysis of Clinical and Paraclinical Characteristics.
Abstract An outbreak of pneumonia, caused by a novel coronavirus (SARS-CoV-2), was identified in China in December 2019. This virus expanded worldwide, causing global concern. Although clinical, laboratory, and imaging features of COVID-19 are characterized in some observational studies, we undertook a systematic review and meta-analysis to assess the frequency of these features. We did a systematic review and meta-analysis using three databases to identify clinical, laboratory, and computerized tomography (CT) scanning features of rRT-PCR confirmed cases of COVID-19. Data for 3420 patients from 30 observational s...
Source: Biomed Res - August 29, 2020 Category: Research Authors: Hasani H, Mardi S, Shakerian S, Taherzadeh-Ghahfarokhi N, Mardi P Tags: Biomed Res Int Source Type: research

A Cross-Sectional Epidemiological Survey of Work-Related Musculoskeletal Disorders and Analysis of Its Influencing Factors among Coal Mine Workers in Xinjiang.
In conclusion, there is a high annual prevalence of MSDs among the coal mine workers employed in on-site operations in Xinjiang, China. Measures to reduce this prevalence are required. PMID: 32851062 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - August 29, 2020 Category: Research Authors: Yong X, Li F, Ge H, Sun X, Ma X, Liu J Tags: Biomed Res Int Source Type: research

Changes in the Clinical Characteristics of 62 Patients Who Died from Coronavirus Disease 2019.
Conclusion: Our findings suggest that during hospitalization, many COVID-19 patients experienced multiple organ dysfunction and cytokine storm. The time from symptom onset to death was only 18.5 days, highlighting the disease's rapid progression. The better understanding of the clinical changes during disease progression might provide further insight into the COVID-19 pathophysiology. PMID: 32851063 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - August 29, 2020 Category: Research Authors: Chen J, Ye J, Li H, Xia Z, Yan H Tags: Biomed Res Int Source Type: research

Gender-Related and Hemispheric Effects in Cortical Thickness-Based Hemispheric Brain Morphological Network.
Abstract Objective: The current study examined gender-related differences in hemispheric asymmetries of graph metrics, calculated from a cortical thickness-based brain structural covariance network named hemispheric morphological network. Methods: Using the T1-weighted magnetic resonance imaging scans of 285 participants (150 females, 135 males) retrieved from the Human Connectome Project (HCP), hemispheric morphological networks were constructed per participant. In these hemispheric morphologic networks, the degree of similarity between two different brain regions in terms of the distributed patterns of cort...
Source: Biomed Res - August 29, 2020 Category: Research Authors: Choi YH, Yun JY, Kim BH, Lee MH, Song SK, Lee JM Tags: Biomed Res Int Source Type: research

Classification of Diabetes Using Photoplethysmogram (PPG) Waveform Analysis: Logistic Regression Modeling.
In this study, a total of 587 subjects were enrolled. A total of 459 subjects were used for model training and development, while the rest of the 128 subjects were used for model testing and validation. The classifier was able to diagnose 63 patients correctly as diabetes while 27 subjects were wrongly classified as nondiabetes with an accuracy of 70%. Again, the model classified 479 subjects as nondiabetes correctly while it incorrectly classified 18 subjects as diabetes with an accuracy of 96.4%. Finally, the proposed model revealed an overall predictive accuracy of 92.3% which makes it a reliable surrogate measure for d...
Source: Biomed Res - August 29, 2020 Category: Research Authors: Qawqzeh YK, Bajahzar AS, Jemmali M, Otoom MM, Thaljaoui A Tags: Biomed Res Int Source Type: research

Transcriptome Profiling across Five Tissues of Giant Panda.
This study provided for the first time the heart, liver, lung, and kidney's transcriptome resources of the giant panda, and it provided a valuable resource for further genetic research or other potential research. PMID: 32851066 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - August 29, 2020 Category: Research Authors: Li F, Wang C, Xu Z, Li M, Deng L, Wei M, Zhang H, Wu K, Ning R, Li D, Yang M, Zhang M, Ni Q, Zeng B, Li D, Li Y Tags: Biomed Res Int Source Type: research

The Abnormal Expression of miR-205-5p, miR-195-5p, and VEGF-A in Human Cervical Cancer Is Related to the Treatment of Venous Thromboembolism.
In this study, 30 cervical cancer subjects treated with CCRT and 30 cervical cancer patients treated with CCRT+LWMH were enrolled. We screened five miRNAs (miR-15a-5p, miR-16-5p, miR-29a-3p, miR-195-5p, and miR-205-5p), which have multiple binding sites with VEGF-A and are highly expressed in serum of patients with cervical cancer, by RT-qPCR. The expression level of VEGF-A was also detected by RT-qPCR and ELISA. Statistical methods were used for difference and correlation analyses. Results: We observed the curative effect in the two treatment methods. In the CCRT group, the total effective rate was 60.00%, and in the...
Source: Biomed Res - August 29, 2020 Category: Research Authors: Wang Y, Zhang Z, Tao P, Reyila M, Qi X, Yang J Tags: Biomed Res Int Source Type: research

Human Microbe-Disease Association Prediction by a Novel Double-Ended Random Walk with Restart.
In this study, we proposed a novel computational model to predict disease-associated microbes. Specifically, we first constructed a heterogeneous interconnection network based on known microbe-disease associations deposited in a few databases, the similarity between diseases, and the similarity between microorganisms. We then predicted novel microbe-disease associations by a new method called the double-ended restart random walk model (DRWHMDA) implemented on the interconnection network. In addition, we performed case studies of colon cancer and asthma for further evaluation. The results indicate that 10 and 9 of the top 1...
Source: Biomed Res - August 29, 2020 Category: Research Authors: Wang D, Cui Y, Cao Y, He Y, Chen H Tags: Biomed Res Int Source Type: research

Protective Effect of Methylxanthine Fractions Isolated from Bancha Tea Leaves against Doxorubicin-Induced Cardio- and Nephrotoxicities in Rats.
Abstract Doxorubicin is an anthracycline antibiotic that is used for the treatment of various types of cancer. However, its clinical usage is limited due to its potential life-threatening adverse effects, such as cardio- and nephrotoxicities. Nonetheless, simultaneous administration of doxorubicin and antioxidants, such as those found in green tea leaves, could reduce cardiac and renal tissue damage caused by oxidative stress. The methylxanthine fraction isolated from Bancha tea leaves were tested in vitro for its antioxidant activity and in vivo for its organoprotective properties against doxorubicin-induced card...
Source: Biomed Res - August 29, 2020 Category: Research Authors: Radeva-Ilieva MP, Georgiev KD, Hvarchanova NR, Stoeva SS, Slavov IJ, Dzhenkov DL, Georgieva MP Tags: Biomed Res Int Source Type: research

Effects of Antiacid Therapy on Granuloma after Transoral Type IV-VI Cordectomy in Patients with Early-Stage Glottic Cancer.
Conclusion: Preventive use of a PPI in patients after type IV-VI cordectomy can shorten the TG recovery duration and may reduce the severity of TG, but it cannot prevent TG from occurring. Our results should be confirmed by prospective randomized controlled trials with large sample sizes. PMID: 32851070 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - August 29, 2020 Category: Research Authors: Jin X, Niu Y, Gu W, Wang J Tags: Biomed Res Int Source Type: research

Discovery and Validation of a CT-Based Radiomic Signature for Preoperative Prediction of Early Recurrence in Hypopharyngeal Carcinoma.
Conclusions: Using the radiomic signature, we developed a radiomic signature to preoperatively predict early recurrence in patients with HSCC, which may serve as a potential noninvasive tool to guide personalized treatment. PMID: 32851071 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - August 29, 2020 Category: Research Authors: Li W, Wei D, Wushouer A, Cao S, Zhao T, Yu D, Lei D Tags: Biomed Res Int Source Type: research

Expression Level and Clinical Significance of NKILA in Human Cancers: A Systematic Review and Meta-Analysis.
Conclusions: In the result of this meta-analysis, decreased NKILA expression is typical of different kinds of cancer. Moreover, it can perform as a predictive element of prognosis in varied kinds of cancer. Nonetheless, till now, it is deemed essential to carry out larger-size as well as better designed research works for the confirmation of our findings. PMID: 32851072 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - August 29, 2020 Category: Research Authors: Tian S, Yu Y, Huang H, Xu A, Xu H, Zhou Y Tags: Biomed Res Int Source Type: research

Functional Evaluation of Upper Urinary Tract with Diuretic Mercaptoacetyltriglycine Renal Scans in Patients with Benign Prostatic Obstruction before and after Surgical Intervention: A Pilot Study.
Conclusion: Storage-phase bladder dysfunction could be a reliable urodynamic factor for the indication of upper urinary tract obstruction in patients with benign prostatic hyperplasia, and upper urinary tract obstruction with subsequent kidney damage could be improved by surgical decompression of benign prostatic obstruction. PMID: 32851073 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - August 29, 2020 Category: Research Authors: Cho SY, Ko K, Koo KC, Kim HJ, Bang WJ, Choo MS, Lee SH, Yoon YE, Jung W, Choi JY, Lee DS, Young Endourological Study (YES) Group Tags: Biomed Res Int Source Type: research

Circular RNA circCCDC66 Contributes to Malignant Phenotype of Osteosarcoma by Sponging miR-338-3p to Upregulate the Expression of PTP1B.
This study aimed to explore the effect of a circRNA, circCCDC66, on OS and reveal its potential molecular mechanism. High circCCDC66 expression level was found in OS patient-derived tissue samples and OS cell lines by qRT-PCR. The abilities cell proliferation and metastatic of U2OS and SW1353 cells were then assessed by Cell Counting Kit-8 and transwell assay, respectively. The interaction between circCCDC66 and its target miRNAs were verified by the dual-luciferase reporter assay. Through functional experiments, we found that circCCDC66 knockdown promoted the inhibition of cell proliferation and metastatic of OS cell line...
Source: Biomed Res - August 29, 2020 Category: Research Authors: Xiang D, Li Y, Lin Y Tags: Biomed Res Int Source Type: research

Preclinical Development of Mahanine-Enriched Fraction from Indian Spice Murraya koenigii for the Management of Cancer: Efficacy, Temperature/pH stability, Pharmacokinetics, Acute and Chronic Toxicity (14-180 Days) Studies.
Abstract Murraya koenigii is well documented in the Indian ancient medical text "Charaka Samhita." The carbazole alkaloid "mahanine" from this plant exhibited anticancer activity against several cancers. Here, we have taken a comprehensive study to standardize the method for the preparation of a mahanine-enriched fraction (MEF) with the highest yield and defined markers. Our optimized method produced MEF having the highest amount of mahanine, a major marker, with excellent in vitro antiproliferative activity against ovarian and breast cancer cells as evidenced by decreased cell viability by MTT...
Source: Biomed Res - August 29, 2020 Category: Research Authors: Satyavarapu EM, Sinha PK, Mandal C Tags: Biomed Res Int Source Type: research

Rosuvastatin Improves Cognitive Function of Chronic Hypertensive Rats by Attenuating White Matter Lesions and Beta-Amyloid Deposits.
In this study, we aimed to investigate the effect of rosuvastatin on cognitive impairment and its underlying mechanisms in chronic hypertensive rats. From the 8th week after establishment of stroke-prone renovascular hypertensive rats (RHRSPs), rosuvastatin (10 mg/kg) or saline as a control was administrated once daily for consecutive 12 weeks by gastric gavage. Cognitive function was assessed with the Morris water maze test and novel object recognition test. WML was observed by Luxol fast blue staining. Aβ deposits, Claudin-5, Occludin, and ZO-1 were determined by immunofluorescence. After rosuvastatin treatme...
Source: Biomed Res - August 29, 2020 Category: Research Authors: Zheng L, Cai Y, Qiu B, Lan L, Lin J, Fan Y Tags: Biomed Res Int Source Type: research

Macrophage Depletion Improves Endothelial Insulin Resistance and Protects against Cardiovascular Injury in Salt-Sensitive Hypertension.
Abstract Vascular endothelial insulin signaling is critical for the maintenance of vascular and metabolic homeostasis. We have previously shown that in hypertensive Dahl rats, impaired vascular insulin action is linked to angiotensin II activation of the NFκB inflammatory pathway. Macrophage polarization (M1) has implicated in hypertensive and metabolic diseases. Here, we investigated the effect of macrophage depletion using liposome-encapsulated clodronate (LEC) on endothelial insulin resistance and cardiovascular remodeling in Dahl salt-sensitive (DS) rats. High salt intake (HS) for 5 weeks increased systo...
Source: Biomed Res - August 29, 2020 Category: Research Authors: Liu YY, Luo J, Cai R, Zhang J, Xu Q, Tian Y, Zhou MS Tags: Biomed Res Int Source Type: research

CT Findings in a Novel Coronavirus Disease (COVID-19) Pneumonia at Initial Presentation.
Conclusions: Most COVID-19 pneumonia patients had abnormalities on chest CT images at initial presentation. Imaging features combined with patient's exposure history and onset symptoms could facilitate the identification of the suspected patient for further examinations. PMID: 32851078 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - August 29, 2020 Category: Research Authors: Xiang C, Lu J, Zhou J, Guan L, Yang C, Chai C Tags: Biomed Res Int Source Type: research

Elevated Level of Serum C-reactive Protein Predicts Postoperative Delirium among Patients Receiving Cervical or Lumbar Surgery.
Abstract Objective: To explore the relationship between elevated serum C-reactive protein (CRP) level and postoperative delirium (POD). Methods: 206 patients scheduled to receive cervical or lumbar vertebra surgery under general anesthesia for more than 2 hours in a single medical center were observed and analyzed. Patients' serum CRP, delirious status (using the confusion assessment method (CAM)), and delirious score (using the memorial delirium assessment scale (MDAS)) were examined before surgery and 1-2 days after surgery. The association of a serum CRP elevation value from before to after surgery (D-CRP)...
Source: Biomed Res - August 29, 2020 Category: Research Authors: Ren Q, Wen YZ, Wang J, Yuan J, Chen XH, Thapa Y, Qiang MS, Xu F Tags: Biomed Res Int Source Type: research

Development of Multiscale Transcriptional Regulatory Network in Esophageal Cancer Based on Integrated Analysis.
Conclusion: We develop a multiscale integrated analysis and suggest that CXCL8, CYP2C8, and E2F1 are promising regulators with good diagnostic and prognostic values in ESCA. PMID: 32851080 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - August 29, 2020 Category: Research Authors: Xu Z, Wu Z, Zhang J, Zhou R, Wu J, Yu B Tags: Biomed Res Int Source Type: research

Elucidation of the Mechanisms and Molecular Targets of Sanhuang Xiexin Decoction for Type 2 Diabetes Mellitus Based on Network Pharmacology.
Abstract Sanhuang Xiexin Decoction (SXD) is commonly used to treat type 2 diabetes mellitus (T2DM) in clinical practice of traditional Chinese medicine (TCM). In order to elucidate the specific analysis mechanisms of SXD for T2DM, the method of network pharmacology was applied to this article. First, the effective ingredients of SXD were obtained and their targets were identified based on the TCMSP database. The T2DM-related targets screened from the GEO database were also collected by comparing the differential expressed genes between T2DM patients and healthy individuals. Then, the common targets in SXD-treated ...
Source: Biomed Res - August 29, 2020 Category: Research Authors: Xu M, Li Z, Yang L, Zhai W, Wei N, Zhang Q, Chao B, Huang S, Cui H Tags: Biomed Res Int Source Type: research

Rapamycin Inhibited Pyroptosis and Reduced the Release of IL-1 β and IL-18 in the Septic Response.
This study shows that RAPA abrogates LPS-mediated increase in IL-1β and IL-18 by inhibiting pyroptosis and enhancing autophagy. PMID: 32851082 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - August 29, 2020 Category: Research Authors: Zhuo L, Chen X, Sun Y, Wang Y, Shi Y, Bu L, Xia W, Han J, Chen D, Li X Tags: Biomed Res Int Source Type: research

Epidemiological Trends in the Form of Childhood Tuberculosis in a Referral Tuberculosis Hospital in Shandong, China.
Conclusion: Our findings suggest that childhood TB is facing new challenges, and the policy should be adjusted timely to fit the real situation. PMID: 32851083 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - August 29, 2020 Category: Research Authors: Wang MS, Wang JL, Liu XJ Tags: Biomed Res Int Source Type: research

Surface Geometry of Four Conventional Nanohybrid Resin-Based Composites and Four Regular Viscosity Bulk Fill Resin-Based Composites after Two-Step Polishing Procedure.
Conclusions: Regular viscosity bulk fill composites do not constitute a homogeneous group regarding surface roughness after polishing. They obtain, for the most part, poorer smoothness values after polishing than conventional RBCs. PMID: 32851084 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - August 29, 2020 Category: Research Authors: Granat M, Cieloszyk J, Kowalska U, Buczkowska-Radlińska J, Łagocka R Tags: Biomed Res Int Source Type: research

The Efficacy of Traditional Chinese Medicine Shoutai Pill Combined with Western Medicine in the First Trimester of Pregnancy in Women with Unexplained Recurrent Spontaneous Abortion: A Systematic Review and Meta-Analysis.
Abstract Background: Shoutai Pill (STP), a famous classic herbal formula documented in traditional Chinese medicine (TCM), is widely available in China for treating unexplained recurrent spontaneous abortion (URSA). This systematic review and meta-analysis aims at evaluating the efficacy and safety of STP in the first trimester of pregnancy in women with a history of unexplained recurrent spontaneous abortion. Methods: The following eight databases were searched from their establishment to Dec 31, 2019, for randomized controlled trials (RCTs): PubMed, Embase, Cochrane Library, Web of Science, China National K...
Source: Biomed Res - August 29, 2020 Category: Research Authors: Li HF, Shen QH, Li XQ, Feng ZF, Chen WM, Qian JH, Shen L, Yu LY, Yang Y Tags: Biomed Res Int Source Type: research

Extracorporeal Shockwave Therapy for Patients with Chronic Achilles Tendinopathy in Long or Short Course.
Abstract Methods: The data of 66 patients with CAT received ESWT was reviewed. According to the disease courses, those cases were allocated to short-term group (ST group, symptom duration 3-6 months) and long-term group (LT group, symptom duration>6 months). Propensity scores match (PSM) method was conducted to eliminate the confound factors in baseline features including gender, sport history, sides, type of CAT, BMI (body mass index), age, and scores evaluated by AOFAS (American Orthopedic Foot and Ankle Society) and VAS (Visual Analogue Scale) before ESWT. After balancing the features between ST and LT group...
Source: Biomed Res - August 29, 2020 Category: Research Authors: Yan B, Wan Y, Zhang H, Pan M, Zhou C Tags: Biomed Res Int Source Type: research

Pharmacists' Knowledge and Practice of Issues Related to Using Psychotropic Medication in Elderly People in Ethiopia: A Prospective Cross-Sectional Study.
This study is aimed at assessing pharmacists' knowledge and practice of issue related to usage of psychotropic medications in elderly people, in Gondar town Northwest, Ethiopia. Methods: A cross-sectional study was conducted among pharmacists working in community, health center, and hospital pharmacies in Gondar town from March 1 to May 30, 2020. A total of 73 medication retail outlets (40 pharmacies and 33 drug stores) were included in this study. Pharmacy personnel's knowledge and practice were assessed using self-administered validated questionnaires. Binary and multivariable logistic regression analyses were used ...
Source: Biomed Res - August 29, 2020 Category: Research Authors: Mekonnen GB, Beyna AT Tags: Biomed Res Int Source Type: research

Magnitude of the Quality Assurance, Quality Control, and Testing in the Shiraz Cohort Heart Study.
Abstract To determine the conclusive integrity in the Shiraz Cohort Heart Study (SCHS) project, management began quality assurance (QA) and quality control (QC) of the collected data throughout the study end-points. The QA is a focused process that prevents and detects data collection errors and verification of intended requirements in the SCHS. The QC is a subset of QA intended to capture errors in processing data through testing and preventive processes to identify problems, defects, or intended requirements. SCHS involved 10,000 males and females aged 40-70 over a 10-year follow-up period with cardiovascular di...
Source: Biomed Res - August 29, 2020 Category: Research Authors: Parsa N, Zibaeenezhad MJ, Trevisan M, Karimi Akhormeh A, Sayadi M Tags: Biomed Res Int Source Type: research

Adverse Drug Reaction Reporting in Ethiopia: Systematic Review.
The objective of this review was to assess the knowledge, attitude, and practice of adverse drug reaction reporting among health care professionals in Ethiopia. Relevant literatures were searched from Google Scholar, PubMed, Hinari, Web of Science, Scopus, and Science Direct using inclusion and exclusion criteria. From 133 searched studies, 13 studies were reviewed. The knowledge and attitude of health care professionals towards adverse drug reaction reporting ranged from 22.68% -60.33% and 47.22% -67.14%, with averages of 41.50% and 57.18%, respectively. While 46.93% encountered adverse drug reactions and 41.8% reported i...
Source: Biomed Res - August 29, 2020 Category: Research Authors: Hailu AD, Mohammed SA Tags: Biomed Res Int Source Type: research

The Utility of Diffusion and Perfusion Magnetic Resonance Imaging in Target Delineation of High-Grade Gliomas.
Conclusions: This study was the first to explore the clinical value of multimodality MRI in the delineation of radiotherapy target volume for HGG. The conclusions of the study have positive reference significance to the combination of multimodality MRI and CE-MRI in guiding the delineation of the radiotherapy target area for HGG patients. PMID: 32851090 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - August 29, 2020 Category: Research Authors: Fei Q, Qian LX, Zhang YJ, Guo WJ, Bian XH, Yin L, Yan PW, Wang TT, Qian PD, Guo Z, He X Tags: Biomed Res Int Source Type: research

AURKA Increase the Chemosensitivity of Colon Cancer Cells to Oxaliplatin by Inhibiting the TP53-Mediated DNA Damage Response Genes.
This study provided a possibility to use AURKA as a biomarker to predict the chemosensitivity of colon cancer to platinum in the clinic. PMID: 32851091 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - August 29, 2020 Category: Research Authors: Shan B, Zhao R, Zhou J, Zhang M, Qi X, Wang T, Gong J, Wu Y, Zhu Y, Yang W, Zhang Y, Wang G, Li X Tags: Biomed Res Int Source Type: research

Metformin Inhibited Proliferation and Metastasis of Colorectal Cancer and presented a Synergistic Effect on 5-FU.
Abstract The purpose of this study was to investigate the effect of metformin or the combination of metformin and 5-FU on the growth and metastasis of colorectal cancer (CRC). For the in vitro experiments, HCT 116 and SW1463 cell lines were treated with metformin or the combination of metformin and 5-FU. Cell proliferation and invasion were analyzed by CCK-8, colony formation, and transwell assay, respectively. For the in vivo experiments, the CRC xenograft nude mice model was used to observe the effects of metformin or combined with 5-FU on tumor growth and metastasis. Metformin significantly inhibited the prolif...
Source: Biomed Res - August 29, 2020 Category: Research Authors: Sang J, Tang R, Yang M, Sun Q Tags: Biomed Res Int Source Type: research

Effect of serum on SmartFlare ™ RNA Probes uptake and detection in cultured human cells.
Effect of serum on SmartFlare™ RNA Probes uptake and detection in cultured human cells. Biomed J Sci Tech Res. 2020;28(4):21788-21793 Authors: Golab K, Krzystyniak A, Langa P, Pikuła M, Kunovac S, Borek P, Trzonkowski P, Millis JM, Fung J, Witkowski P Abstract SmartFlare™ RNA Detection Probes from Millipore is a novel technology to detect RNA in live cells based on the use of 12 nm gold nanoparticles coated with nucleotides. We proved that SmartFlares™ are internalized by human primary lymphocytes. However, fluorescence signals from target RNA detection can only be observed in the p...
Source: Biomed Res - August 29, 2020 Category: Research Authors: Golab K, Krzystyniak A, Langa P, Pikuła M, Kunovac S, Borek P, Trzonkowski P, Millis JM, Fung J, Witkowski P Tags: Biomed J Sci Tech Res Source Type: research

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and Polychlorinated Biphenyl Coexposure Alters the Expression Profile of MicroRNAs in the Liver Associated with Atherosclerosis.
Abstract MicroRNAs (miRNAs) are a class of small RNAs that regulate gene expression. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and polychlorinated biphenyls (PCBs) are persistent organic pollutants that exist as complex mixtures in vivo. When humans are simultaneously exposed to these compounds, the development of atherosclerosis is known to be enhanced. However, the roles of miRNA in TCDD- and PCB-induced atherosclerosis are largely unknown. Therefore, the present study is aimed at elucidating the possible dysregulation of miRNAs in atherogenesis induced by coexposure to TCDD and PCBs. Eight-week-old male ApoE-/...
Source: Biomed Res - August 29, 2020 Category: Research Authors: Shan Q, Qu F, Chen N Tags: Biomed Res Int Source Type: research

The Development and Application of a Base Editor in Biomedicine.
Abstract Using a base editor to generate monogenic disease models and correct pathogenic point mutations is a breakthrough technology for exploration and treatment of human diseases. As a burgeoning approach for genomic modification, the fused CRISPR/Cas9 with various deaminase separately has significantly increased the efficiency of producing a precise point mutation with minimal insertions or deletions (indels). Along with the flexibility and efficiency, a base editor has been widely used in many fields. This review discusses the recent development of a base editor, including evolution and advance, and highlight...
Source: Biomed Res - August 29, 2020 Category: Research Authors: Wang F, Zeng Y, Wang Y, Niu Y Tags: Biomed Res Int Source Type: research

Dorsal Horn of Mouse Lumbar Spinal Cord Imaged with CLARITY.
In conclusion, CLARITY confirmed the 2D immunohistochemical properties of the spinal cord. Furthermore, we observed novel anatomical characteristics of the spinal cord and demonstrated that CLARITY can be used on spinal cord tissue to examine many proteins of interest. PMID: 32855963 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - August 29, 2020 Category: Research Authors: Sengul G, Liang H, Furlong TM, Paxinos G Tags: Biomed Res Int Source Type: research

Potential Pharmacokinetic Drug-Drug Interactions between Cannabinoids and Drugs Used for Chronic Pain.
ich P Abstract Choosing an appropriate treatment for chronic pain remains problematic, and despite the available medication for its treatment, still, many patients complain about pain and appeal to the use of cannabis derivatives for pain control. However, few data have been provided to clinicians about the pharmacokinetic drug-drug interactions of cannabinoids with other concomitant administered medications. Therefore, the aim of this brief review is to assess the interactions between cannabinoids and pain medication through drug transporters (ATP-binding cassette superfamily members) and/or metabolizing enzymes ...
Source: Biomed Res - August 29, 2020 Category: Research Authors: Vázquez M, Guevara N, Maldonado C, Guido PC, Schaiquevich P Tags: Biomed Res Int Source Type: research

Uniaxial Static Strain Promotes Osteoblast Proliferation and Bone Matrix Formation in Distraction Osteogenesis In Vitro.
Conclusion: Our homemade device can exert uniaxial static strain and promote the proliferation of osteoblasts and bone matrix formation. It can be used to simulate the mechanical stimulation of osteoblasts during DO. PMID: 32855965 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - August 29, 2020 Category: Research Authors: Li Z, Zheng J, Wan D, Yang X Tags: Biomed Res Int Source Type: research

An UPLC-MS/MS Method for Simultaneous Quantification of the Components of Shenyanyihao Oral Solution in Rat Plasma.
Conclusions: This pharmacokinetic study seems to be useful for a further clinical study of Shenyanyihao oral solution in the treatments of chronic nephritis. PMID: 32855966 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - August 29, 2020 Category: Research Authors: Jiang C, Liang G, Ren Y, Xu T, Song Y, Jin W Tags: Biomed Res Int Source Type: research

Circular RNA circ_0026359 Enhances Cisplatin Resistance in Gastric Cancer via Targeting miR-1200/POLD4 Pathway.
In this study, circular RNA circ_0026359 was demonstrated to be overexpressed in gastric cancer tissues/cells compared with normal gastric tissues/cells and was overexpressed in CDDP-resistant gastric cancer tissues/cells compared with CDDP-sensitive gastric cancer tissues/cells. High levels of circ_0026359 were associated with low overall survival (OS) and relapse-free survival (RFS) rates in gastric cancer patients. circ_0026359 was examined to promote CDDP resistance in gastric cancer cells. circ_0026359 directly interacted and negatively regulated miR-1200. POLD4 was a direct target of miR-1200. miR-1200/POLD4 pathway ...
Source: Biomed Res - August 29, 2020 Category: Research Authors: Zhang Z, Yu X, Zhou B, Zhang J, Chang J Tags: Biomed Res Int Source Type: research

Prediction Model of HBsAg Seroclearance in Patients with Chronic HBV Infection.
Conclusions: We established and validated a novel nomogram that can individually predict HBsAg seroclearance and non-seroclearance for CHB patients, which is clinically unprecedented. This practical prognostic model may help clinicians in decision-making and design of clinical studies. PMID: 32855968 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - August 29, 2020 Category: Research Authors: Cao J, Gong J, Tsia Hin Fong CJ, Xiao C, Lin G, Li X, Jie Y, Chong Y Tags: Biomed Res Int Source Type: research

Transcriptomics Study to Determine the Molecular Mechanism by which sIL-13R α2-Fc Inhibits Caudal Intervertebral Disc Degeneration in Rats.
Conclusion: Adamts8 may participate in the degradation of ECM components such as GAG and HA and lead to an imbalance in the ECM of the intervertebral disc, resulting in intervertebral disc degeneration. sIL-13Rα2-Fc promoted anabolism of the ECM and increased the levels of ECM components by inhibiting the expression of Adamts8, thus maintaining the dynamic equilibrium of the ECM and ultimately delaying intervertebral disc degeneration. PMID: 32855969 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - August 29, 2020 Category: Research Authors: Wang X, Tan J, Sun J, Fang P, Chen J, Yuan W, Chen H, Liu Y Tags: Biomed Res Int Source Type: research

Association between Insulin-Like Growth Factor-1 and Relative Skeletal Maturation: A Retrospective Cohort Study of Short Children and Adolescents.
Abstract Objective: Delays in skeletal maturity are related to bone mass and fracture risk in children, but the factors that determine it are unknown. We aimed to identify the association between insulin-like growth factor-1 (IGF-1) and skeletal maturation before and after growth hormone (GH) treatment. Methods: In this retrospective cohort study, we observed 783 short children and adolescents, 229 of whom received GH therapy. Skeletal maturation was assessed based on the difference between bone age (BA) and chronological age (CA) (noted as BA-CA). Anthropometric data and laboratory values were measured, and ...
Source: Biomed Res - August 29, 2020 Category: Research Authors: Zhao Q, Zhang M, Chu Y, Ji B, Pan H, Sun H, Ban B Tags: Biomed Res Int Source Type: research

Identification and Characterization of MAPK Signaling Pathway Genes and Associated lncRNAs in the Ileum of Piglets Infected by Clostridium perfringens Type C.
Abstract Clostridium perfringens type C (C. perfringens type C) is one of the main microbial pathogens responsible for piglet diarrhea worldwide, causing substantial economic losses for pig-rearing industries. The mitogen-activated protein kinase (MAPK) signaling pathway is a key regulator of inflammatory bowel disease, especially necrotic enteritis. However, whether and how the MAPK signaling pathway is involved in regulating the process of piglet diarrhea when challenged by C. perfringens type C are still unknown. Here, we screened 38 differentially expressed genes (DEGs) in piglets' ileum tissues experimentally...
Source: Biomed Res - August 29, 2020 Category: Research Authors: Luo R, Huang X, Yan Z, Gao X, Wang P, Yang Q, Wang W, Xie K, Gun S Tags: Biomed Res Int Source Type: research

Tranexamic Acid for Blood Loss after Transforaminal Posterior Lumbar Interbody Fusion Surgery: A Double-Blind, Placebo-Controlled, Randomized Study.
Conclusions: TXA shows important ability in controlling blood loss and promoting the ERAS after TLIF surgery. PMID: 32855972 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - August 29, 2020 Category: Research Authors: He B, Li Y, Xu S, Ou Y, Zhao J Tags: Biomed Res Int Source Type: research

Immunomodulatory property and its regulatory mechanism of double network hydrogel on dendritic cells.
This article is protected by copyright. All rights reserved. PMID: 32856407 [PubMed - as supplied by publisher] (Source: Biomed Res)
Source: Biomed Res - August 28, 2020 Category: Research Authors: Zhu F, Tong Y, Wu Y, Dong N, Sheng Z, Yao Y Tags: J Biomed Mater Res A Source Type: research