Regulation of Pancreatic TXNIP-Insulin Expression Levels after Bariatric Surgery Using Diabetic Rodent Model
CONCLUSION: Bariatric surgery significantly improved glucose control and regulated the pancreatic insulin production pathways of TXNIP, miR-204, and MafA. The regulation of TXNIP, miR-204, and MafA might play an important role in the mechanism of diabetes remission following bariatric surgery.PMID:36733403 | PMC:PMC9889143 | DOI:10.1155/2023/9563359 (Source: Biomed Res)
Source: Biomed Res - February 3, 2023 Category: Research Authors: Jason Widjaja Yuxiao Chu Jian Wang Jian Hong Xiaocheng Zhu Libin Yao Source Type: research

Circular RNA circ_0026218 Suppressed Atherosclerosis Progression via miR-338-3p/SIRT6 Axis
CONCLUSION: Collectively, circ_0026218 upregulates SIRT6 expression through decoying miR-338-3p, thereby inhibiting ox-LDL-initiated injury of HUVECs. circ_0026218 is involved in the pathogenesis of AS.PMID:36733404 | PMC:PMC9889145 | DOI:10.1155/2023/5647758 (Source: Biomed Res)
Source: Biomed Res - February 3, 2023 Category: Research Authors: Liang Yang Wei Chen Bin Li Yvbao Hu Hua Lu Pan Zhang Huayun Yang Mochen Zhang Diguang Pan Source Type: research

Diagnosis of Prostate Cancer Using GLCM Enabled KNN Technique by Analyzing MRI Images
Biomed Res Int. 2023 Jan 24;2023:3913351. doi: 10.1155/2023/3913351. eCollection 2023.ABSTRACTCancer has a disproportionately large influence on the death rate of adults. A patient needs to get a diagnosis of their condition as quickly as is humanly feasible in order to have the greatest chance of surviving their sickness. Skilled medical professionals use medical imaging and other traditional diagnostic methods to search for clues that may indicate the presence of malignant tendencies inside the body. Nevertheless, manual diagnosis may be time-consuming and subjective owing to the wide range of interobserver variability i...
Source: Biomed Res - February 3, 2023 Category: Research Authors: L Anand Shivlal Mewada WameedDeyah Shamsi Mahyudin Ritonga Noza Aflisia Prakash KumarSarangi Moses NdoleArthur Source Type: research

Association of RNA m < sup > 7 < /sup > G Modification Gene Polymorphisms with Pediatric Glioma Risk
This study is aimed at determining the association of glioma risk with three polymorphisms (rs2291617, rs10877013, and rs10877012) in METTL1 and five polymorphisms (rs2156315 rs2156316, rs6586250, rs15736, and rs2248490) in WDR4 gene in children of Chinese Han. We enrolled 314 cases and 380 controls from three independent hospitals. Genotypes of these polymorphisms were determined using the TaqMan assay. We found the WDR4 gene rs15736 was significantly associated with reduced glioma risk (GA/AA vs. GG: adjusted odds ratio = 0.63, 95%confidence interval = 0.42 - 0.94, P = 0.023) out of the eight studied polymorphisms. Strat...
Source: Biomed Res - February 3, 2023 Category: Research Authors: Jinhong Zhu Xiaoping Liu Wei Chen Yuxiang Liao Jiabin Liu Li Yuan Jichen Ruan Jing He Source Type: research

Anti-inflammatory, Antinociceptive, and Toxicological Properties of < em > Uvaria comperei < /em > Stem Crude Extract and Fractions
Biomed Res Int. 2023 Jan 23;2023:2754725. doi: 10.1155/2023/2754725. eCollection 2023.ABSTRACTThe present study was carried out to investigate the anti-inflammatory activity of a methanolic extract and fractions of Uvaria comperei stems. The crude extract was obtained by maceration of the powder in methanol and fractions by vacuum chromatography from the methanolic extract. To study the anti-inflammatory activity in vitro, red blood cell lysis inhibition assay and albumin denaturation inhibition were performed, while in vivo measurements of carrageenan-induced paw oedema and formalin-induced pain in albino mice were perfor...
Source: Biomed Res - February 2, 2023 Category: Research Authors: Marguerite Kamdem Simo Gael Tchokomeni Siwe Maurice Taboula Kayo Zheng Chen Mersimine Mangoua Kouamo Darline Dize Pierre Dongmo Jazet Modeste Lambert Sameza Fabrice Boyom Fekam Guglielmina Froldi Source Type: research

In Silico Structural and Functional Analyses of NLRP3 Inflammasomes to Provide Insights for Treating Neurodegenerative Diseases
Biomed Res Int. 2023 Jan 23;2023:9819005. doi: 10.1155/2023/9819005. eCollection 2023.ABSTRACTInflammasomes are cytoplasmic intracellular multiprotein complexes that control the innate immune system's activation of inflammation in response to derived chemicals. Recent advancements increased our molecular knowledge of activation of NLRP3 inflammasomes. Although several studies have been done to investigate the role of inflammasomes in innate immunity and other diseases, structural, functional, and evolutionary investigations are needed to further understand the clinical consequences of NLRP3 gene. The purpose of this study ...
Source: Biomed Res - February 2, 2023 Category: Research Authors: Behram Khan Ghazi Maria Hussain Bangash Anam Abdul Razzaq Madiha Kiyani Shishay Girmay Waleed Razzaq Chaudhary Usman Zahid Uzma Hussain Huma Mujahid Usama Parvaiz Irfan Ahmed Buzdar Shah Nawaz Mohamed Farouk Elsadek Source Type: research

The Effect of < em > Citrus aurantium < /em > on Non-Small-Cell Lung Cancer: A Research Based on Network and Experimental Pharmacology
CONCLUSION: Citrus aurantium can participate in the treatment of NSCLC through multiple targets and pathways.PMID:36726839 | PMC:PMC9886468 | DOI:10.1155/2023/6407588 (Source: Biomed Res)
Source: Biomed Res - February 2, 2023 Category: Research Authors: Liangliang Yao Xuan Zhang Chaoming Huang Yi Cai Chunpeng Craig Wan Source Type: research

Long Noncoding RNA NORAD Promotes Fracture Healing through Interacting with Osteoblast Differentiation via Targeting miR-26a
This study showed no significant differences in serum NORAD expression on the 7th day during fracture healing in patients, but increased expression of NORAD was certified on the 14, 21, and 28 days after fixation. Overexpression of NORAD promoted the proliferation and differentiation of osteoblasts and suppressed the apoptosis of osteoblasts. miR-26a proved to be the target gene of NORAD and was inhibited by overexpression of NORAD in osteoblasts. The enhanced expression of miR-26a was negatively linked to the lessened expression of NORAD. NORAD could accelerate the proliferation and differentiation of osteoblasts and inhi...
Source: Biomed Res - February 2, 2023 Category: Research Authors: Siyuan Chen Huili Ma Mintao Li Zhuting Jia Xi Chen Naitong Bu Source Type: research

Analysis of Potential Mechanism of Herbal Formula Taohong Siwu Decoction against Vascular Dementia Based on Network Pharmacology and Molecular Docking
In this study, a network pharmacology approach together with molecular docking validation was used to explore the probable mechanism of action of TSD against VaD. A total of 44 active components, 202 potential targets of components, and 3,613 VaD-related targets including 161 intersecting were obtained. The potential chemical components including kaempferol, baicalein, beta-carotene, luteolin, quercetin, and beta-sitosterol involved in the inflammatory response, oxidative stress, and apoptosis might have potential therapeutic effects on the treatment of VaD. The potential core targets including AKT1, CASP3, IL1β, JUN, and...
Source: Biomed Res - February 2, 2023 Category: Research Authors: Ruixin He Fengjiao He Zhenliang Hu Yifang He Xinting Zeng Yao Liu Liang Tang Ju Xiang Jianming Li Binsheng He Qin Xiang Source Type: research

Physical Activity among Rural Residents in Eastern, Central, and Western Provinces of China: A Cross-Sectional Survey
This study conducted the first population-based cross-sectional survey in three provinces of China in 2021 that examined both PA and PE as well as the associated factors of rural residents. The International Physical Activity Questionnaire Short Form (IPAQ-S) was used, and a total of 3780 rural residents were surveyed. The result showed that 22.2% of the rural residents were physical inactivity and rural residents reporting practice of PE was 54.4%. Binary logistic regression analyses showed that being female, people aged between 15 to 34 years or 60 years old and above, employees of governmental departments/retirees, scho...
Source: Biomed Res - February 2, 2023 Category: Research Authors: Cheng-Yao Liang Zhi-Yuan Zheng Yu-Gao Wu Zhuo-Yang Li Ping Wang Yi-Yang Wang Bai-Xue Lin Jing Fang Source Type: research

Colorimetry-Based Phosphate Measurement for Polymerase Elongation
This study introduced a simple and direct colorimetric method to measure polymerase-directed elongation. First, pyrophosphate (PPi), a by-product of strand extension, is converted into phosphate (Pi). Phosphate levels were measured using either Mo-Sb or BIOMOL Green reagent. This study showed that this colorimetry can distinguish single-base variants and detect PCR products in preset stringent conditions, implicating the potential value of this strategy to detect DNA.PMID:36726843 | PMC:PMC9886478 | DOI:10.1155/2023/8296847 (Source: Biomed Res)
Source: Biomed Res - February 2, 2023 Category: Research Authors: Han Yang Xiaoxin Ji Xiao Li Yunran Feng Ke Zhang Xuemin Guo Zhixiong Zhong Xin Mu Source Type: research

Recent Approaches for Downplaying Antibiotic Resistance: Molecular Mechanisms
Biomed Res Int. 2023 Jan 23;2023:5250040. doi: 10.1155/2023/5250040. eCollection 2023.ABSTRACTAntimicrobial resistance (AMR) is a ubiquitous public health menace. AMR emergence causes complications in treating infections contributing to an upsurge in the mortality rate. The epidemic of AMR in sync with a high utilization rate of antimicrobial drugs signifies an alarming situation for the fleet recovery of both animals and humans. The emergence of resistant species calls for new treatments and therapeutics. Current records propose that health drug dependency, veterinary medicine, agricultural application, and vaccination re...
Source: Biomed Res - February 2, 2023 Category: Research Authors: Sarfraz Ahmed Muhammad Zeeshan Ahmed Safa Rafique Seham Eid Almasoudi Mohibullah Shah Nur Asyilla Che Jalil Suvash Chandra Ojha Source Type: research

The detection of the captured circulating tumor cells on the core-shell nanofibrous membrane using hyaluronic acid-functionalized graphene quantum dots
J Biomed Mater Res B Appl Biomater. 2023 Feb 2. doi: 10.1002/jbm.b.35219. Online ahead of print.ABSTRACTIn recent years, cancerous cases have increased remarkably worldwide, and metastasis is the leading cause of death. Therefore, research on the early detection of cancer and metastasis has expanded to aid successful cancer treatment. Here in this paper, at the first step, an electrospun nanofibrous membrane (NFM) with a core-shell structure was fabricated from PCL and HA to achieve cancer cell capturing (about 75% of cells). On the other hand, hyaluronic acid (HA)-functionalized graphene quantum dots (GQDs) were used to d...
Source: Biomed Res - February 2, 2023 Category: Research Authors: Sahar Asghari Matin Mahmoudifard Source Type: research

Ultrasound-derived mechanical stimulation of cell-laden collagen hydrogels for bone repair
J Biomed Mater Res A. 2023 Feb 2. doi: 10.1002/jbm.a.37508. Online ahead of print.ABSTRACTCell therapy is emerging as an effective treatment strategy for many diseases. Here we describe a novel approach to bone tissue repair that combines hydrogel-based cell therapy with low intensity pulsed ultrasound (LIPUS), an FDA approved treatment for fracture repair. Bone marrow-derived stromal cells (BMSCs) have been encapsulated in type I collagen hydrogels and mechanically stimulated using LIPUS-derived acoustic radiation force (ARF). We observed the expression and upward trend of load-sensitive, osteoblast-specific markers and d...
Source: Biomed Res - February 2, 2023 Category: Research Authors: Fayekah Assanah Kevin Grassie Hanna Anderson Xiaonan Xin David Rowe Yusuf Khan Source Type: research

Anti-inflammatory, Antinociceptive, and Toxicological Properties of < em > Uvaria comperei < /em > Stem Crude Extract and Fractions
Biomed Res Int. 2023 Jan 23;2023:2754725. doi: 10.1155/2023/2754725. eCollection 2023.ABSTRACTThe present study was carried out to investigate the anti-inflammatory activity of a methanolic extract and fractions of Uvaria comperei stems. The crude extract was obtained by maceration of the powder in methanol and fractions by vacuum chromatography from the methanolic extract. To study the anti-inflammatory activity in vitro, red blood cell lysis inhibition assay and albumin denaturation inhibition were performed, while in vivo measurements of carrageenan-induced paw oedema and formalin-induced pain in albino mice were perfor...
Source: Biomed Res - February 2, 2023 Category: Research Authors: Marguerite Kamdem Simo Gael Tchokomeni Siwe Maurice Taboula Kayo Zheng Chen Mersimine Mangoua Kouamo Darline Dize Pierre Dongmo Jazet Modeste Lambert Sameza Fabrice Boyom Fekam Guglielmina Froldi Source Type: research