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Influence of Material Selection on the Marginal Accuracy of CAD/CAM-Fabricated Metal- and All-Ceramic Single Crown Copings.
This study evaluated the marginal accuracy of CAD/CAM-fabricated crown copings from four different materials within the same processing route. Twenty stone replicas of a metallic master die (prepared upper premolar) were scanned and divided into two groups. Group 1 (n = 10) was used for a pilot test to determine the design parameters for best marginal accuracy. Group 2 (n = 10) was used to fabricate 10 specimens from the following materials with one identical CAD/CAM system (GAMMA 202, Wissner GmbH, Goettingen, Germany): A = commercially pure (cp) titanium, B = cobalt-chromium alloy, C = yttria-stabilized zirconia (YSZ), a...
Source: Biomed Res - May 18, 2018 Category: Research Authors: Rödiger M, Schneider L, Rinke S Tags: Biomed Res Int Source Type: research

Aerobic Interval Training Regulated SIRT3 Attenuates High-Fat-Diet-Associated Cognitive Dysfunction.
In this study, we investigated whether aerobic interval training (AIT) could attenuate high-fat-diet- (HFD-) associated cognitive dysfunction and the possible mechanism of SIRT3-MnSOD pathway. C57BL/6 wild-type (WT) mice and SIRT3 knockout (KO) mice were randomized into control (Con) or HFD group with or without AIT training for 6 weeks. The spatial learning and memory ability were impaired in HFD group compared to the control group. The levels of mitochondrial protein acetylation were increased in the hippocampus of HFD group. The acetylation level of antioxidative MnSOD was increased as well. As a result, the ROS and MDA...
Source: Biomed Res - May 18, 2018 Category: Research Authors: Shi Z, Li C, Yin Y, Yang Z, Xue H, Mu N, Wang Y, Liu M, Ma H Tags: Biomed Res Int Source Type: research

Correlation between Allergic Rhinitis and Laryngopharyngeal Reflux.
Abstract Background and Objectives: Laryngopharyngeal reflux (LPR) exhibits nonspecific clinical presentations, and these symptoms may be associated with other conditions such as allergies, including allergic rhinitis and laryngitis. However, there is a gap in the literature regarding the correlation of laryngopharyngeal reflux with allergic rhinitis/laryngitis. Hence, the aim of this study is to explore the correlation between these two conditions. Patients and Methods: A total of 126 patients with suggestive manifestations of laryngopharyngeal reflux were included in this study. Patients were classified int...
Source: Biomed Res - May 18, 2018 Category: Research Authors: Alharethy S, Baqays A, Mesallam TA, Syouri F, Al Wedami M, Aldrees T, AlQabbani A Tags: Biomed Res Int Source Type: research

Time Course of Detection of Human Male DNA from Stained Blood Sample on Various Surfaces by Loop Mediated Isothermal Amplification and Polymerase Chain Reaction.
This study explores determining the sex of humans from blood stains taken from different surfaces and compares the time course of detection with the conventional PCR, Conventional Loop Mediated Isothermal Amplification (LAMP), and LAMP-Lateral Flow Dipstick (LFD). For the DNA templates, 7 male and 7 female blood stained samples were extracted and added to LAMP and PCR reaction solution to amplify the SRY gene. The DNA samples were extracted from the following blood stained materials: cloth, wood, clay, and tile. Then, the samples were stored at room temperature for 1, 7, 30, and 60 day(s). After the DNA amplification, the ...
Source: Biomed Res - May 18, 2018 Category: Research Authors: Kanchanaphum P Tags: Biomed Res Int Source Type: research

A Clinical Study of Toxication Caused by Carbamazepine Abuse in Adolescents.
Abstract Carbamazepine is known to produce the side effect of euphoria. As such, it lends itself to being a drug of abuse, particularly in the adolescent population. This retrospective study evaluated carbamazepine abuse, treatment course, and associated morbidity in Chinese adolescents. The median dose of carbamazepine resulting in overdose was 2,000 mg (800-5,000). Patients were largely from urban-rural fringe areas (76.47%, 52.94%) with school performance within the last 1/3 range and (52.94%) unsupervised by parents. 35.29% experienced an obvious sense of euphoria. All patients had nervous system sympto...
Source: Biomed Res - May 18, 2018 Category: Research Authors: Xu W, Chen YL, Zhao Y, Wang LJ, Li JJ, Liu CF Tags: Biomed Res Int Source Type: research

JAZF1 Inhibits Adipose Tissue Macrophages and Adipose Tissue Inflammation in Diet-Induced Diabetic Mice.
This study aimed to examine JAZF1 overexpression in vivo on adipose tissue macrophages (ATMs). Methods: Mouse models of high-fat diet- (HFD-) induced insulin resistance were induced using C57BL/6J and JAZF1-overexpressing (JAZF1-OX) mice. The mice were randomized (8-10/group) to C57BL/6J mice fed regular diet (RD) (NC group), C57BL/6J mice fed HFD (HF group), JAZF1-OX mice fed RD (NJ group), and JAZF1-OX mice fed HFD (HJ group). Adipose tissue was harvested 12 weeks later. ATMs were evaluated by flow cytometry. Inflammatory markers were evaluated by ELISA. Results: JAZF1-OX mice had lower blood lipids, blood gluc...
Source: Biomed Res - May 18, 2018 Category: Research Authors: Meng F, Lin Y, Yang M, Li M, Yang G, Hao P, Li L Tags: Biomed Res Int Source Type: research

Effects of Afternoon Nap Deprivation on Adult Habitual Nappers' Inhibition Functions.
Abstract Multiple studies have established the effects of afternoon naps on cognition. However, relatively few studies have investigated the domain of executive functions. Moreover, the effects of napping on inhibition are far from conclusive. The present study employed adult habitual nappers to investigate the effects of afternoon nap deprivation on response-based inhibition assessed by a Go/No-go task and stimulus-based inhibition assessed by a Flanker task and on alertness assessed by a psychomotor vigilance test (PVT) and the Karolinska Sleepiness Scale (KSS). The results showed that afternoon nap deprivation ...
Source: Biomed Res - May 18, 2018 Category: Research Authors: Chen Q, Ru T, Yang M, Yan P, Li J, Yao Y, Li X, Zhou G Tags: Biomed Res Int Source Type: research

Characterization and Comparative Analysis of the Complete Chloroplast Genome of the Critically Endangered Species Streptocarpus teitensis (Gesneriaceae).
Abstract Streptocarpus teitensis (Gesneriaceae) is an endemic species listed as critically endangered in the International Union for Conservation of Nature (IUCN) red list of threatened species. However, the sequence and genome information of this species remains to be limited. In this article, we present the complete chloroplast genome structure of Streptocarpus teitensis and its evolution inferred through comparative studies with other related species. S. teitensis displayed a chloroplast genome size of 153,207 bp, sheltering a pair of inverted repeats (IR) of 25,402 bp each split by small and larg...
Source: Biomed Res - May 18, 2018 Category: Research Authors: Kyalo CM, Gichira AW, Li ZZ, Saina JK, Malombe I, Hu GW, Wang QF Tags: Biomed Res Int Source Type: research

In Vitro Cytotoxicity and In Vivo Antimammary Tumor Effects of the Hydroethanolic Extract of Acacia seyal (Mimosaceae) Stem Bark.
Abstract The present study was designed to evaluate the in vitro and in vivo antitumor effects of A. seyal hydroethanolic extract on breast cancer. The cytotoxicity of A. seyal extract was evaluated using resazurin reduction assay in 9 cell lines. Further, the protective effect of the hydroethanolic extract of A. seyal stem barks was evaluated on 7,12-dimethylbenz(a)anthracene- (DMBA-) induced breast cancer rat model. Incidence, burden, volume, and histological analysis of mammary tumors were measured. The Acacia seyal extract exhibited CC50 of 100 in MCF-7 cells after 24 h. In vivo, no tumors were detected...
Source: Biomed Res - May 18, 2018 Category: Research Authors: Zingue S, Njuh AN, Tueche AB, Tamsa J, Tchoupang EN, Kakene SD, Sipping MTK, Njamen D Tags: Biomed Res Int Source Type: research

Second Blood Meal by Female Lutzomyia longipalpis: Enhancement by Oviposition and Its Effects on Digestion, Longevity, and Leishmania Infection.
Abstract Lutzomyia longipalpis is the main vector of visceral leishmaniasis (VL) in America. Physiological and molecular mechanisms of Leishmania infection in sand flies have been studied during the first gonotrophic cycle. There are few studies about these interactions during the second gonotrophic cycle mainly because of the difficulties maintaining sand flies through sequential feeds. Here we standardized conditions to perform the second blood feed efficiently, and our results show that oviposition is an essential factor for the success of multiple feeds. We evaluated the impact of the second blood meal on long...
Source: Biomed Res - May 18, 2018 Category: Research Authors: Moraes CS, Aguiar-Martins K, Costa SG, Bates PA, Dillon RJ, Genta FA Tags: Biomed Res Int Source Type: research

AEG-1 Contributes to Metastasis in Hypoxia-Related Ovarian Cancer by Modulating the HIF-1alpha/NF-kappaB/VEGF Pathway.
This study aimed to explore the mechanism by which AEG-1 regulates metastasis in hypoxia induced ovarian carcinoma. Patients and Methods: AEG-1, HIF-1α, and VEGF protein amounts were evaluated by immunohistochemistry in 40 and 170 normal ovary and ovarian cancer tissue specimens, respectively. In addition, AEG-1, HIF-1α, NF-κB, and VEGF mRNA and protein levels were determined by reverse quantified RT-PCR and WB, respectively, at different time periods (0-24 h) in epithelial ovarian cancer (EOC) SKOV3 cells treated in a hypoxia incubator. Furthermore, NF-κB and VEGF gene and protein expre...
Source: Biomed Res - May 18, 2018 Category: Research Authors: Yu X, Wang Y, Qiu H, Song H, Feng D, Jiang Y, Deng S, Meng H, Geng J Tags: Biomed Res Int Source Type: research

The Prediction of Drug-Disease Correlation Based on Gene Expression Data.
Abstract The explosive growth of high-throughput experimental methods and resulting data yields both opportunity and challenge for selecting the correct drug to treat both a specific patient and their individual disease. Ideally, it would be useful and efficient if computational approaches could be applied to help achieve optimal drug-patient-disease matching but current efforts have met with limited success. Current approaches have primarily utilized the measureable effect of a specific drug on target tissue or cell lines to identify the potential biological effect of such treatment. While these efforts have met ...
Source: Biomed Res - May 18, 2018 Category: Research Authors: Cui H, Zhang M, Yang Q, Li X, Liebman M, Yu Y, Xie L Tags: Biomed Res Int Source Type: research

Bauhinia variegata candida Fraction Induces Tumor Cell Death by Activation of Caspase-3, RIP, and TNF-R1 and Inhibits Cell Migration and Invasion In Vitro.
RIMA Abstract Metastasis remains the most common cause of death in cancer patients. Inhibition of metalloproteinases (MMPs) is an interesting approach to cancer therapy because of their role in the degradation of extracellular matrix (ECM), cell-cell, and cell-ECM interactions, modulating key events in cell migration and invasion. Herein, we show the cytotoxic and antimetastatic effects of the third fraction (FR3) from Bauhinia variegata candida (Bvc) stem on human cervical tumor cells (HeLa) and human peripheral blood mononuclear cells (PBMCs). FR3 inhibited MMP-2 and MMP-9 activity, indicated by zymogram. This ...
Source: Biomed Res - May 18, 2018 Category: Research Authors: Santos KM, Gomes INF, Silva-Oliveira RJ, Pinto FE, Oliveira BG, Chagas RCR, Romão W, Reis RMV, Ribeiro RIMA Tags: Biomed Res Int Source Type: research

Incidence and Extent of Graft Extrusion following Meniscus Allograft Transplantation.
Abstract Background: The incidence and extent of graft extrusion after meniscus allograft transplantation (MAT) may differ in patients undergoing medial and lateral meniscus transplantation due to the use of different surgical techniques. This meta-analysis was therefore designed to quantify the extent and incidence of graft extrusion after meniscus allograft transplantation. Methods: Following preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines, all studies reporting absolute extrusion, relative percentage of extrusion (RPE), or frequency of major extrusions (>3 m...
Source: Biomed Res - May 18, 2018 Category: Research Authors: Lee DH Tags: Biomed Res Int Source Type: research

Diagnosis and Incidence of Spondylosis and Cervical Disc Disorders in the University Clinical Hospital in Olsztyn, in Years 2011-2015.
Conclusion: Significant number of patients presenting with either of the spine disorders at the young age of 31-40 years points to the necessity of introducing methods preventing disorders of the vertebral column at younger age, preferably at school age. PMID: 29770333 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - May 18, 2018 Category: Research Authors: Kolenkiewicz M, Włodarczyk A, Wojtkiewicz J Tags: Biomed Res Int Source Type: research

Optimum Antithrombotic Therapy in Patients Requiring Long-Term Anticoagulation and Undergoing Percutaneous Coronary Intervention.
Abstract Management of patients on long-term anticoagulation requiring percutaneous coronary intervention is challenging. Triple therapy with oral anticoagulant and dual antiplatelet therapy is the standard of care. However, there is no strong evidence to support this strategy. There is emerging data regarding the safety and efficacy of dual therapy with oral anticoagulant and single antiplatelet therapy in these patients. In this comprehensive review we highlight available evidence regarding various antithrombotic regimens' efficacy and safety in patient with coronary artery disease undergoing percutaneous corona...
Source: Biomed Res - May 18, 2018 Category: Research Authors: Agarwal N, Mahtta D, Rambarat CA, Elgendy I, Mahmoud AN Tags: Biomed Res Int Source Type: research

The Significance of Scalp Involvement in Pemphigus: A Literature Review.
Abstract Scalp is a unique location for pemphigus because of the abundance of desmogleins localized in hair follicles. Scalp involvement is observed in up to 60% of patients in the course of pemphigus. The lesions may occasionally lead to alopecia. Unforced removal of anagen hairs in a pull test is a sign of high disease activity. Direct immunofluorescence of plucked hair bulbs is considered a reliable diagnostic method in patients with pemphigus. Follicular acantholysis is a characteristic histopathological feature of pemphigus lesions localized on the scalp. Trichoscopy may serve as a supplementary method in the...
Source: Biomed Res - May 18, 2018 Category: Research Authors: Sar-Pomian M, Rudnicka L, Olszewska M Tags: Biomed Res Int Source Type: research

Epigallocatechin-3-Gallate Reduces Neuronal Apoptosis in Rats after Middle Cerebral Artery Occlusion Injury via PI3K/AKT/eNOS Signaling Pathway.
Conclusion: EGCG has a protective effect on rat brain injury induced by MCAO, possibly by modulating the PI3K/AKT/eNOS signaling pathway. PMID: 29770336 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - May 18, 2018 Category: Research Authors: Nan W, Zhonghang X, Keyan C, Tongtong L, Wanshu G, Zhongxin X Tags: Biomed Res Int Source Type: research

Chlamydia pneumoniae Infection Exacerbates Atherosclerosis in ApoB100only/LDLR-/- Mouse Strain.
Conclusion: Similar to ApoE-/- mice, ApoB100only/LDLR-/- mice with more human-relevant serum lipoprotein composition develop increased atherosclerosis after Cpn infections; thus this mouse strain can be used as a model of infection-related atherosclerosis enhancement and can provide further evidence for the proatherogenic influence of Cpn in mice. PMID: 29770337 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - May 18, 2018 Category: Research Authors: Lantos I, Endrész V, Virok DP, Szabó A, Lu X, Mosolygó T, Burián K Tags: Biomed Res Int Source Type: research

Basic Fibroblast Growth Factor Fused with Tandem Collagen-Binding Domains from Clostridium histolyticum Collagenase ColG Increases Bone Formation.
Abstract Basic fibroblast growth factor 2 (bFGF) accelerates bone formation during fracture healing. Because the efficacy of bFGF decreases rapidly following its diffusion from fracture sites, however, repeated dosing is required to ensure a sustained therapeutic effect. We previously developed a fusion protein comprising bFGF, a polycystic kidney disease domain (PKD; s2b), and collagen-binding domain (CBD; s3) sourced from the Clostridium histolyticum class II collagenase, ColH, and reported that the combination of this fusion protein with a collagen-like peptide, poly(Pro-Hyp-Gly)10, induced mesenchymal cell pro...
Source: Biomed Res - May 18, 2018 Category: Research Authors: Sekiguchi H, Uchida K, Matsushita O, Inoue G, Nishi N, Masuda R, Hamamoto N, Koide T, Shoji S, Takaso M Tags: Biomed Res Int Source Type: research

Using poly(l-lactic acid) and poly( ɛ-caprolactone) blends to fabricate self-expanding, watertight and biodegradable surgical patches for potential fetoscopic myelomeningocele repair.
Using poly(l-lactic acid) and poly(ɛ-caprolactone) blends to fabricate self-expanding, watertight and biodegradable surgical patches for potential fetoscopic myelomeningocele repair. J Biomed Mater Res B Appl Biomater. 2018 May 16;: Authors: Tatu R, Oria M, Pulliam S, Signey L, Rao MB, Peiro JL, Lin CY Abstract Our study focuses on the development and characterization of a self-expanding, watertight and biodegradable patch for fetoscopic myelomeningocele (MMC) prenatal repair. We fabricated poly(l-lactic acid) (PLA) and poly(ɛ-caprolactone) (PCL) blend films by solution casting. Formulation c with a...
Source: Biomed Res - May 16, 2018 Category: Research Authors: Tatu R, Oria M, Pulliam S, Signey L, Rao MB, Peiro JL, Lin CY Tags: J Biomed Mater Res B Appl Biomater Source Type: research

Effect of silicon-doped calcium phosphate bone grafting materials on bone regeneration and osteogenic marker expression after implantation in the ovine scapula.
This study evaluated the effect of these two particulate graft materials as compared to the currently clinically used β-TCP on bone formation and osteogenic marker expression after 2 weeks, 1, 3, 6, 12, and 18 months of implantation in critical size defects in the sheep scapula. Immunohistochemical analysis of collagen type I, alkaline phosphatase, and osteocalcin expression was performed on resin embedded sections. The bone and particle area fraction and the bone-biomaterial contact were determined histomorphometrically. After 2 weeks and 1 month defects grafted with Si-CAOP displayed a significantly greater bone are...
Source: Biomed Res - May 16, 2018 Category: Research Authors: Knabe C, Adel-Khattab D, Hübner WD, Peters F, Knauf T, Peleska B, Barnewitz D, Genzel A, Kusserow R, Sterzik F, Stiller M, Müller-Mai C Tags: J Biomed Mater Res B Appl Biomater Source Type: research

Influence of collagen-based integrin α1 and α2 mediated signaling on human mesenchymal stem cell osteogenesis in three dimensional contexts.
This article is protected by copyright. All rights reserved. PMID: 29761640 [PubMed - as supplied by publisher] (Source: Biomed Res)
Source: Biomed Res - May 15, 2018 Category: Research Authors: Becerra-Bayona SM, Guiza-Arguello VR, Russell B, Höök M, Hahn MS Tags: J Biomed Mater Res A Source Type: research

Characterization of the Transmitted Virus in an Ongoing HIV-1 Epidemic Driven by Injecting Drug Use.
This study focused on seven newly infected participants in St. Petersburg, Russia, who were in acute or early infection. We used end-point dilution PCR to amplify single viral genomes to assess the complexity of the transmitted virus. We also used deep sequencing to further assess the complexity of the virus. We interpret the results as indicating that a single viral variant was transmitted in each case, consistent with a model where the exposure to virus during transmission was limiting. We also looked at phenotypic properties of the viral Env protein in isolates from acute and chronic infection. Although differences were...
Source: Biomed Res - May 14, 2018 Category: Research Authors: Dukhovlinova E, Masharsky A, Vasileva A, Porrello A, Zhou S, Toussova O, Verevochkin S, Akulova E, Frishman D, Montefiori D, Labranche C, Hoffman I, Miller W, Cohen MS, Kozlov A, Swanstrom R Tags: AIDS Res Hum Retroviruses Source Type: research

Corrigendum to "Effects of rhBMP-2 Loaded Titanium Reinforced Collagen Membranes on Horizontal Bone Augmentation in Dogs".
Corrigendum to "Effects of rhBMP-2 Loaded Titanium Reinforced Collagen Membranes on Horizontal Bone Augmentation in Dogs". Biomed Res Int. 2018;2018:8318136 Authors: Lee KS, Jeon YS, Shin SW, Lee JY Abstract [This corrects the article DOI: 10.1155/2017/7141296.]. PMID: 29749969 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - May 13, 2018 Category: Research Authors: Lee KS, Jeon YS, Shin SW, Lee JY Tags: Biomed Res Int Source Type: research

Sensitive Detection of the Natural Killer Cell-Mediated Cytotoxicity of Anti-CD20 Antibodies and Its Impairment by B-Cell Receptor Pathway Inhibitors.
M, Krause G Abstract The antibody-dependent cell-mediated cytotoxicity (ADCC) of the anti-CD20 monoclonal antibodies (mAbs) rituximab and obinutuzumab against the cell line Raji and isolated CLL cells and its potential impairment by kinase inhibitors (KI) was determined via lactate dehydrogenase release or calcein retention, respectively, using genetically modified NK92 cells expressing CD16-176V as effector cells. Compared to peripheral blood mononuclear cells, recombinant effector cell lines showed substantial alloreactivity-related cytotoxicity without addition of mAbs but afforded determination of ADCC with re...
Source: Biomed Res - May 13, 2018 Category: Research Authors: Hassenrück F, Knödgen E, Göckeritz E, Midda SH, Vondey V, Neumann L, Herter S, Klein C, Hallek M, Krause G Tags: Biomed Res Int Source Type: research

Beryllium Stress-Induced Modifications in Antioxidant Machinery and Plant Ultrastructure in the Seedlings of Black and Yellow Seeded Oilseed Rape.
Abstract Beryllium (Be) could be a threatening heavy metal pollutant in the agroecosystem that may severely affect the performance of crops. The present study was conducted to evaluate the toxic effects of Be (0, 100, 200, and 400 μM) on physiological, ultrastructure, and biochemical attributes in hydroponically grown six-day-old seedlings of two cultivars of Brassica napus L., one tolerant (ZS 758, black seeded) and one sensitive (Zheda 622, yellow seeded). Higher Be concentrations reduced the plant growth, biomass production, chlorophyll contents, and the total soluble protein contents. A significant a...
Source: Biomed Res - May 13, 2018 Category: Research Authors: Ali S, Jin R, Gill RA, Mwamba TM, Zhang N, Hassan ZU, Islam F, Ali S, Zhou W Tags: Biomed Res Int Source Type: research

Expression and Regulation Profile of Mature MicroRNA in the Pig: Relevance to Xenotransplantation.
Abstract The pig is an important source of meat production and provides a valuable model for certain human diseases. MicroRNA (miRNA), which is noncoding RNA and regulates gene expression at the posttranscriptional level, plays a critical role in various biological processes. Studies on identification and function of mature miRNAs in multiple pig tissues are increasing, yet the literature is limited. Therefore, we reviewed current research to determine the miRNAs expressed in specific pig tissues that are involved in carcass values (including muscle and adipocytes), reproduction (including pituitary, testis, and o...
Source: Biomed Res - May 13, 2018 Category: Research Authors: Song Z, Cooper DKC, Cai Z, Mou L Tags: Biomed Res Int Source Type: research

The Antioxidative Function of Alpha-Ketoglutarate and Its Applications.
Abstract Alpha-ketoglutarate (AKG) is a crucial intermediate of the Krebs cycle and plays a critical role in multiple metabolic processes in animals and humans. Of note, AKG contributes to the oxidation of nutrients (i.e., amino acids, glucose, fatty acids) and then provides energy for cell processes. As a precursor of glutamate and glutamine, AKG acts as an antioxidant agent as it directly reacts with hydrogen peroxide with formation of succinate, water, and carbon dioxide; meanwhile, it discharges plenty of ATP by oxidative decarboxylation. Recent studies also show that AKG has alleviative effect on oxidative st...
Source: Biomed Res - May 13, 2018 Category: Research Authors: Liu S, He L, Yao K Tags: Biomed Res Int Source Type: research

In Vitro Lethal Activity of the Nematophagous Fungus Clonostachys rosea (Ascomycota: Hypocreales) against Nematodes of Five Different Taxa.
This study was aimed to evaluate the in vitro lethal activity of the nematophagous fungi Clonostachys rosea against 5 nematodes species belonging to different taxa. Two groups of 35 Petri dishes (PD) each were divided into 5 series of 7 (PD). Group 1 (series 1, 2, 3, 4, and 5) contained only water agar; meanwhile group 2 plates (series 6, 7, 8, 9, and 10) contained C. rosea cultures growth on water agar. Every plate from the two groups was added with 500 nematodes corresponding to the following genera/specie: Haemonchus contortus, Caenorhabditis elegans, Rhabditis sp., Panagrellus redivivus, and Butlerius sp. After 5-day i...
Source: Biomed Res - May 13, 2018 Category: Research Authors: Rodríguez-Martínez R, Mendoza-de-Gives P, Aguilar-Marcelino L, López-Arellano ME, Gamboa-Angulo M, Hanako Rosas-Saito G, Reyes-Estébanez M, Guadalupe García-Rubio V Tags: Biomed Res Int Source Type: research

Axis-Guided Vessel Segmentation Using a Self-Constructing Cascade-AdaBoost-SVM Classifier.
We describe a very different segmentation method based on a cascade-AdaBoost-SVM classifier. This classifier works with a vessel axis + cross-section model, which constrains the classifier around the vessel. This has the potential to be both physiologically accurate and computationally effective. To further increase the segmentation accuracy, we organize the AdaBoost classifiers and the Support Vector Machine (SVM) classifiers in a cascade way. And we substitute the AdaBoost classifier with the SVM classifier under special circumstances to overcome the overfitting issue of the AdaBoost classifier. The performance of our me...
Source: Biomed Res - May 13, 2018 Category: Research Authors: Hu X, Cheng Y, Ding D, Chu D Tags: Biomed Res Int Source Type: research

Automatic Myotendinous Junction Tracking in Ultrasound Images with Phase-Based Segmentation.
This study demonstrated that the proposed method was robust to the interference of nontendinous components, resulting in a more reliable measurement of MTJ displacement, which may facilitate further research and applications related to the architectural change of muscles and tendons. PMID: 29750152 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - May 13, 2018 Category: Research Authors: Zhou GQ, Zhang Y, Wang RL, Zhou P, Zheng YP, Tarassova O, Arndt A, Chen Q Tags: Biomed Res Int Source Type: research

Health-Related Quality of Life in Pulmonary Hypertension and Its Clinical Correlates: A Cross-Sectional Study.
Conclusions: HRQoL, measured by two different PROMs, is impaired in Portuguese patients with PAH and other forms of pcPH, particularly in patients with increased disease severity. WHO FC, 6MWD, and Borg dyspnoea index are highly correlated with HRQoL and QoL. PMID: 29750153 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - May 13, 2018 Category: Research Authors: Reis A, Santos M, Vicente M, Furtado I, Cruz C, Melo A, Carvalho L, Gonçalves F, Sa-Couto P, Almeida L Tags: Biomed Res Int Source Type: research

Ginsenoside Rg3 Suppresses Proliferation and Induces Apoptosis in Human Osteosarcoma.
In this study, we investigated the efficacy of Rg3 in human osteosarcoma cell lines (MG-63, U-2OS, and SaOS-2). Cell proliferation was measured by CCK8 assay. The migration of cells was examined using the scratch assay method. Quantification of apoptosis was assessed further by flow cytometry. In addition, the expression of apoptosis-related genes (caspase9, caspase3, Bcl2, and Bax) were investigated using RT-PCR. We further investigated the protein level expression of Bcl 2, cleaved-caspase3, and PI3K/AKT/mTOR signaling pathway factors by Western blot assay. Our results revealed that Rg3 inhibited the proliferation and mi...
Source: Biomed Res - May 13, 2018 Category: Research Authors: Li Y, Lu J, Bai F, Xiao Y, Guo Y, Dong Z Tags: Biomed Res Int Source Type: research

Association between Subclinical Low Serum 25(OH)D in Donors and Fatty Liver Disease in Recipients after Living Donor Liver Transplantation.
Abstract To explore subclinical fatty liver disease (FLD) in donors as a possible mechanism leading to FLD in recipients of living donor liver transplantation (LDLT), we extracted thirty donor-recipient pairs' serum DNA and explored the presence of CYP2R1 single nucleotide polymorphism (SNP) rs10741657 and vitamin D receptor (VDR) SNP rs2228530 A/G alleles using real-time polymerase chain reaction. We measured the serum 25(OH)D concentrations and investigated the CYP2R1 and VDR genotypes of the donors and recipients before and after LDLT for comparison with the histological findings from the donors on wedge biopsy...
Source: Biomed Res - May 13, 2018 Category: Research Authors: Chiu KW, Nakano T, Hu TH, Chen KD, Hsu LW, Eng HL, Cheng YF, Goto S, Chen CL Tags: Biomed Res Int Source Type: research

Right Ventricle Remodeling and Function in Scleroderma Patients.
Abstract Scleroderma, known also as systemic sclerosis (SSc), is a severe disease associated with high mortality rates, and right ventricular (RV) remodeling and dysfunction, along with pulmonary artery hypertension (PAH), are among the most important internal organ manifestations of this disease. PAH has a higher prevalence in patients with SSc compared to the general population and represents a significant predictor of mortality in SSc. In patients with SSc, the morphological remodeling and alteration of RV function begin even before the setting of PAH and lead to development of a specific adaptive pattern of th...
Source: Biomed Res - May 13, 2018 Category: Research Authors: Cucuruzac R, Muntean I, Benedek I, Mester A, Rat N, Mitre A, Chitu M, Benedek T Tags: Biomed Res Int Source Type: research

Corrigendum to "Natural Treatment Systems as Sustainable Ecotechnologies for the Developing Countries".
Corrigendum to "Natural Treatment Systems as Sustainable Ecotechnologies for the Developing Countries". Biomed Res Int. 2018;2018:4761769 Authors: Mahmood Q, Pervez A, Zeb BS, Zaffar H, Yaqoob H, Waseem M, Zahidullah, Afsheen S Abstract [This corrects the article DOI: 10.1155/2013/796373.]. PMID: 29750157 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - May 13, 2018 Category: Research Authors: Mahmood Q, Pervez A, Zeb BS, Zaffar H, Yaqoob H, Waseem M, Zahidullah, Afsheen S Tags: Biomed Res Int Source Type: research

Cancer Immunotherapy and Identification of Prognostic and Predictive Biomarkers.
PMID: 29750158 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - May 13, 2018 Category: Research Authors: Criscitiello C, Santangelo M, Loupakis F Tags: Biomed Res Int Source Type: research

Thrombin Assessment on Nanostructured Label-Free Aptamer-Based Sensors: A Mapping Investigation via Surface-Enhanced Raman Spectroscopy.
Abstract Aptamers, synthetic single-stranded DNA or RNA molecules, can be regarded as a valuable improvement to develop novel ad hoc sensors to diagnose several clinical pathologies. Their intrinsic potential is related to the high specificity and sensitivity to the selected target biomarkers, being capable of detecting very low concentrations and thus allowing an early diagnosis of a possible disease. This kind of probe can be usefully integrated into a number of different devices in order to provide a reliable acquisition of the analyte and properly elaborate the related signal. The study presents the fabricatio...
Source: Biomed Res - May 13, 2018 Category: Research Authors: Scatena E, Pascale S, Cairone C, Fabbri F, Del Gaudio C Tags: Biomed Res Int Source Type: research

Temporal Trends of Common Female Malignances on Breast, Cervical, and Ovarian Cancer Mortality in Japan, Republic of Korea, and Singapore: Application of the Age-Period-Cohort Model.
Conclusions: Our study shows that the ASMRs of breast, cervical, and ovarian cancer remain high in Singapore compared to Japan and Korea. Generally speaking, the mortality risk of three cancers increased with age, and period and cohort effects may collectively affect the common female malignances mortality for East Asian women. PMID: 29750160 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - May 13, 2018 Category: Research Authors: Wang J, Lv H, Xue Z, Wang L, Bai Z Tags: Biomed Res Int Source Type: research

Does the Width of the Bony Cochlear Nerve Canal Predict the Outcomes of Cochlear Implantation?
This study evaluated the implications of BCNC width for post-CI outcomes. A total of 56 children who had received CIs were included. The patients were divided into three groups according to the width of the BCNC (Group 1: diameter 2.0 mm, n = 25). The post-CI speech performances were compared among the three groups according to BCNC width. The correlation between BCNC width and post-CI speech performance was evaluated. Logistic regression analysis was also performed to investigate factors that can impact post-CI speech performance. Cochlear nerve deficiency (CND) occurred more frequently in Group 1. Groups 1 and 2 h...
Source: Biomed Res - May 13, 2018 Category: Research Authors: Chung J, Jang JH, Chang SO, Song JJ, Cho SW, Kim SY, Lee JH, Oh SH Tags: Biomed Res Int Source Type: research

Screening of Serum Protein Markers for Avascular Osteonecrosis of Femoral Head Differentially Expressed after Treatment with Yuanshi Shengmai Chenggu Tablets.
Abstract Avascular necrosis of the femoral head (ANFH) is an a frequently occurring orthopaedic disease with high morbidity. Traditional Chinese Medicine (TCM) Yuanshi Shengmai Chenggu Tablet is a valid prescription for treating steroid-induced femoral head necrosis. However, there are rare investigations about the serum protein marker expression after the acting of drugs on hormone and TCM. In the present study, we aimed to systematically discover and validate the serum biomarkers expression difference in patients with steroid-induced avascular necrosis of femoral head (SANFH) after taking Yuanshi Shengmai Chengg...
Source: Biomed Res - May 13, 2018 Category: Research Authors: Deng P, Zeng J, Li J, Feng W, Chen J, Zeng Y Tags: Biomed Res Int Source Type: research

SRMDAP: SimRank and Density-Based Clustering Recommender Model for miRNA-Disease Association Prediction.
Abstract Aberrant expression of microRNAs (miRNAs) can be applied for the diagnosis, prognosis, and treatment of human diseases. Identifying the relationship between miRNA and human disease is important to further investigate the pathogenesis of human diseases. However, experimental identification of the associations between diseases and miRNAs is time-consuming and expensive. Computational methods are efficient approaches to determine the potential associations between diseases and miRNAs. This paper presents a new computational method based on the SimRank and density-based clustering recommender model for miRNA-...
Source: Biomed Res - May 13, 2018 Category: Research Authors: Li X, Lin Y, Gu C, Li Z Tags: Biomed Res Int Source Type: research

Corrigendum to "Classification of Non-Small Cell Lung Cancer Using Significance Analysis of Microarray-Gene Set Reduction Algorithm".
Corrigendum to "Classification of Non-Small Cell Lung Cancer Using Significance Analysis of Microarray-Gene Set Reduction Algorithm". Biomed Res Int. 2018;2018:6031094 Authors: Zhang L, Wang L, Du B, Wang T, Tian P, Tian S Abstract [This corrects the article DOI: 10.1155/2016/2491671.]. PMID: 29750164 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - May 13, 2018 Category: Research Authors: Zhang L, Wang L, Du B, Wang T, Tian P, Tian S Tags: Biomed Res Int Source Type: research

How Artificial Intelligence Can Improve Our Understanding of the Genes Associated with Endometriosis: Natural Language Processing of the PubMed Database.
Abstract Endometriosis is a disease characterized by the development of endometrial tissue outside the uterus, but its cause remains largely unknown. Numerous genes have been studied and proposed to help explain its pathogenesis. However, the large number of these candidate genes has made functional validation through experimental methodologies nearly impossible. Computational methods could provide a useful alternative for prioritizing those most likely to be susceptibility genes. Using artificial intelligence applied to text mining, this study analyzed the genes involved in the pathogenesis, development, and prog...
Source: Biomed Res - May 13, 2018 Category: Research Authors: Bouaziz J, Mashiach R, Cohen S, Kedem A, Baron A, Zajicek M, Feldman I, Seidman D, Soriano D Tags: Biomed Res Int Source Type: research

Statistical Validation for Clinical Measures: Repeatability and Agreement of Kinect ™-Based Software.
Conclusion: The main conclusion is that the software is capable of offering a clinical history of the patient and is useful for quantification of the rehabilitation success. The simplicity, low cost, and visualization possibilities enhance the use of the software Kinect for rehabilitation and other applications, and the expert's opinion endorses the choice of our approach for clinical practice. Comparison of the new measurement technique with established goniometric methods determines that the proposed software agrees sufficiently to be used interchangeably. PMID: 29750166 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - May 13, 2018 Category: Research Authors: Lopez N, Perez E, Tello E, Rodrigo A, Valentinuzzi ME Tags: Biomed Res Int Source Type: research

Prognostic Significance of Blood Transfusion in Elderly Patients with Primary Diffuse Large B-Cell Lymphoma.
Abstract The current study sought to evaluate whether blood transfusions affect survival of elderly patients with primary diffuse large B-cell lymphoma (DLBCL). A total of 104 patients aged 60 years and over were enrolled and divided into two groups: 24 patients who received transfusions and 80 patients who did not. Statistical analyses showed significant differences in LDH levels, platelet (Plt) counts, and hemoglobin (Hb) and albumin (Alb) levels between the two groups. Univariate analyses showed that LDH level ≥ 245 IU/L, cell of origin (germinal center/nongerminal center), and blood transfusion were ...
Source: Biomed Res - May 13, 2018 Category: Research Authors: Fan L, Fu D, Hong J, Huang H, He W, Zeng F, Lin Q, Xie Q Tags: Biomed Res Int Source Type: research

Effect of Icariin on Tibial Dyschondroplasia Incidence and Tibial Characteristics by Regulating P2RX7 in Chickens.
Abstract Tibial dyschondroplasia (TD) is a disease of rapid growing chickens that occurs in many avian species; it is characterized by nonvascular and nonmineralized growth plates, along with tibia bone deformation and lameness. Icariin is widely used to treat bone diseases in humans, but no report is available regarding the effectiveness of icariin against avian TD. Therefore, this study was designed to determine its effect against TD. For this purpose, a total of 180 broiler chicks were distributed into three groups including control, TD, and icariin group. Control group was given a standard normal diet, while T...
Source: Biomed Res - May 13, 2018 Category: Research Authors: Zhang H, Mehmood K, Jiang X, Yao W, Iqbal M, Li K, Tong X, Wang L, Wang M, Zhang L, Nabi F, Rehman MU, Li J Tags: Biomed Res Int Source Type: research

Drosophila as a Model System to Study Cell Signaling in Organ Regeneration.
Abstract Regeneration is a fascinating phenomenon that allows organisms to replace or repair damaged organs or tissues. This ability occurs to varying extents among metazoans. The rebuilding of the damaged structure depends on regenerative proliferation that must be accompanied by proper cell fate respecification and patterning. These cellular processes are regulated by the action of different signaling pathways that are activated in response to the damage. The imaginal discs of Drosophila melanogaster have the ability to regenerate and have been extensively used as a model system to study regeneration. Drosophila...
Source: Biomed Res - May 13, 2018 Category: Research Authors: Ahmed-de-Prado S, Baonza A Tags: Biomed Res Int Source Type: research

Electroporation with Cisplatin against Metastatic Pancreatic Cancer: In Vitro Study on Human Primary Cell Culture.
In conclusion, we discovered that electroporation can enhance the cytotoxic effect of cisplatin in pancreatic cancer cells in vitro. This effect was evident for cells from the primary culture. The obtained results confirm the importance of primary cells models in studies on the efficacy of experimental cancer therapies. PMID: 29750170 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - May 13, 2018 Category: Research Authors: Michel O, Kulbacka J, Saczko J, Mączyńska J, Błasiak P, Rossowska J, Rzechonek A Tags: Biomed Res Int Source Type: research