SARS-CoV-2 encoded microRNAs are involved in the process of virus infection and host immune response
This study aims to uncover the mechanism for SARS-CoV-2 pathogenicity from the perspective of miRNA. We scanned the SARS-CoV-2 genome for putative miRNA genes and miRNA targets and conducted in vivo experiments to validate the virus-encoded miRNAs and their regulatory role on the putative targets. One of such virus-encoded miRNAs, MR147-3p, was overexpressed that resulted in significantly decreased transcript levels of all of the predicted targets in human, i.e., EXOC7, RAD9A, and TFE3 in the virus-infected cells. The analysis showed that the immune response and cytoskeleton organization are two of the most notable biologi...
Source: Biomed Res - May 8, 2021 Category: Research Authors: Zhi Liu Jianwei Wang Yiyue Ge Yuyu Xu Mengchen Guo Kai Mi Rui Xu Yang Pei Qiankun Zhang Xiaoting Luan Zhibin Hu Ying Chi Xingyin Liu Source Type: research

Investigation of water-insoluble hydrophobic polyethylenimines as RNAi vehicles in chronic myeloid leukemia therapy
J Biomed Mater Res A. 2021 May 8. doi: 10.1002/jbm.a.37214. Online ahead of print.ABSTRACTThe discovery of RNA interference (RNAi) more than two decades ago opened avenues for avant-garde cancer treatments that possess the ability to evade issues hampering current chemotherapeutic strategies, owing to its specific gene sequence-driven mechanism of action. A potent short interfering RNA (siRNA) delivery vehicle designed to overcome physiological barriers is imperative for successful RNAi therapy. For this purpose, this study explored the characteristics and therapeutic efficacy of low-molecular weight (MW) polyethylenimine ...
Source: Biomed Res - May 8, 2021 Category: Research Authors: Aysha S Ansari Remant K C Xiaoyan Jiang Hasan Uluda ǧ Source Type: research

Property modelling of lysozyme-crosslinker-alginate complexes using latent variable methods
J Biomed Mater Res A. 2021 May 8. doi: 10.1002/jbm.a.37207. Online ahead of print.ABSTRACTStatistical methods were used to provide insight into a polymer complex system composed of lysozyme and alginate to quantify the effects of such parameters as pH, and ionic composition of the mixing solution on the properties of the complexes including composition, particle diameter, and zeta potential. Various crosslinkers (calcium, barium, iron[III], and bovine serum albumin), were used with lysozyme for complex formation to investigate the effect of crosslinker charge density on protein release kinetics, modelled using ktn . Multiv...
Source: Biomed Res - May 8, 2021 Category: Research Authors: Vida Rahmani Rand Elshereef Heather Sheardown Source Type: research

Mechanical and in vitro biological properties of uniform and graded Cobalt-chrome lattice structures in orthopedic implants
This study aimed at comparing mechanical properties and biological behavior in vitro of uniform (POR-FIX) and graded (POR-VAR) Cobalt-chrome alloy lattice structures manufactured via Selective Laser Melting. In compression, the POR-VAR equivalent maximum stress was about 2.5 times lower than that of the POR-FIX. According to the DIC analysis, the graded lattice structures showed a stratified deformation associated to unit cells variation. At each timepoint, osteoblast cells were observed to colonize the surface and the first layer of both scaffolds. Cell activity was always significantly higher in the POR-VAR (p
Source: Biomed Res - May 8, 2021 Category: Research Authors: Stefania Pagani Erica Liverani Gianluca Giavaresi Angela De Luca Claudio Belvedere Alessandro Fortunato Alberto Leardini Milena Fini Luca Tomesani Paolo Caravaggi Source Type: research

A comparative study on fabrication techniques of gelable bone matrix derived from porcine tibia
In conclusion, the soluble, biodegradable, and biocompatible natures of the precipitated DDBM digest allow its usage in bone tissue engineering as a protein carrier because of its resemblance to native bone-like protein composite and operative flexibility.PMID:33964121 | DOI:10.1002/jbm.b.34860 (Source: Biomed Res)
Source: Biomed Res - May 8, 2021 Category: Research Authors: Wuwei Li Feilong Wang Cleon Barnett Bo Wang Source Type: research

The Circulating Midkine in the Newly Diagnosed Celiac Disease: Clinical Implications
CONCLUSIONS: The study results suggest that the MK marker does not have any diagnostic value in CeD activity to be used at the time of diagnosis or during follow-ups.PMID:33959558 | PMC:PMC8095258 | DOI:10.4103/abr.abr_8_20 (Source: Biomed Res)
Source: Biomed Res - May 7, 2021 Category: Research Authors: Mohammad Hassan Emami Shima Soltani Nahid Eskandari Mohsen Masjedi Source Type: research

Correlation between Stable Hyperglycemia and Mortality in Children Admitted to the Pediatric Intensive Care Unit of Imam Hossein Hospital
Adv Biomed Res. 2021 Jan 27;10:2. doi: 10.4103/abr.abr_31_20. eCollection 2021.ABSTRACTBACKGROUND: Stress-induced hyperglycemia is an important issue among pediatrics admitted in the pediatric intensive care unit (PICU). Former studies have declared that hyperglycemia has a high prevalence rate and could increase the risks of mortality among pediatrics. Here, we aimed to investigate the prevalence rate of hyperglycemia and its effects on mortality among pediatrics in the PICU of the hospital.MATERIALS AND METHODS: This cross-sectional study was performed in 2018-2019 on 88 patients admitted in PICU. Data regarding blood su...
Source: Biomed Res - May 7, 2021 Category: Research Authors: Mohsen Reisi Majid Keivanfar Neda Mostofizadeh Yahya Madihi Yousof Esmaeilian Elham Hashemi Source Type: research

Molecular Typing of Community-acquired Methicillin-Resistant < em > Staphylococcus aureus < /em > Isolated from 2- to 6-year old Children by Staphylococcal Protein A and < em > Agr < /em > Typing in Isfahan, Iran
CONCLUSIONS: The results of our study show that the rate of MRSA in our region is significantly high. Additionally, spa type t037 was the predominant type among CA S. aureus.PMID:33959560 | PMC:PMC8095255 | DOI:10.4103/abr.abr_139_20 (Source: Biomed Res)
Source: Biomed Res - May 7, 2021 Category: Research Authors: Sina Mobasherizadeh Hasan Shojaei Davood Azadi Seyed Asghar Havaei Behrooz Ataei Farzin Khorvash Source Type: research

Fabrication and Characterization of Glycerol/Chitosan/Polyvinyl Alcohol-Based Transparent Hydrogel Films Loaded with Silver Nanoparticles for Antibacterial Wound Dressing Applications
CONCLUSION: Our new fabricated dressing, glycerol/chitosan/PVA hydrogel loaded with AgNPs, exhibited satisfactory wound healing properties.PMID:33959561 | PMC:PMC8095260 | DOI:10.4103/abr.abr_211_20 (Source: Biomed Res)
Source: Biomed Res - May 7, 2021 Category: Research Authors: Ali Samadi Saeed Azandeh Mahmoud Orazizadeh Vahid Bayati Mohammad Rafienia Masoud Ali Karami Source Type: research

Report of a Case of Paraquat Poisoning and Mediastinal Involvement
Adv Biomed Res. 2021 Jan 27;10:5. doi: 10.4103/abr.abr_95_20. eCollection 2021.ABSTRACTParaquat has been recognized as a highly toxic agent for pest removal and is used worldwide. In adults, paraquat poisoning for suicidal attempts is much more common than accidental exposure poisoning. Approximately 20% of patients with paraquat poisoning develop pneumomediastonium as a complication with a mortality rate of approximately 100%. A 19-year-old man patient was admitted to the poisoning emergency department of Khorshid hospital, who had ingested paraquat. He had nausea and vomiting and had normal vital signs and examination in...
Source: Biomed Res - May 7, 2021 Category: Research Authors: Shiva Samsamshariat Amirhossein Vedaei Sharare Jahangiri Mahdi Badiee Gavarti Ramin Sami Abolfazl Taheri Gholamali Dorooshi Source Type: research

Human T-Cell Leukemia Virus Type 1 Changes Leukocyte Number and Oxidative Stress in the Lung and Blood of Female BALB/c Mice
Adv Biomed Res. 2021 Jan 30;10:6. doi: 10.4103/abr.abr_117_20. eCollection 2021.ABSTRACTBACKGROUND: Human T-cell leukemia virus type 1(HTLV-1) infection is likely to induce nonneoplastic inflammatory pulmonary diseases. Therefore, an experimental study was conducted to evaluate the leukocytes' number alteration and oxidative stress in the lung and blood of HTLV-1-infected BALB/c mice, which could be of benefit for the recognition of HTLV-1 mechanism in the induction of pulmonary disorders.MATERIALS AND METHODS: Twenty female BALB/c mice were divided into two groups of control and HTLV-1-infected animals. The HTLV-1-infecte...
Source: Biomed Res - May 7, 2021 Category: Research Authors: Mahdiyeh Hedayati-Moghadam S A Rahim Rezaee Mohammad Hossein Boskabady Nema Mohamadian Roshan Saeideh Saadat Kowsar Bavarsad Saeed Niazmand Source Type: research

The Prevalence of Hepatitis B Virus Markers among Students of Shiraz University of Medical Sciences
CONCLUSION: Findings of the current study show that more than half of the students do not have a protective level of anti-HBsAb and might be susceptible to HBV infection, indicating the necessity of checking the level of anti-HBsAb as well as a booster dose in high-risk groups.PMID:33959564 | PMC:PMC8095257 | DOI:10.4103/abr.abr_173_20 (Source: Biomed Res)
Source: Biomed Res - May 7, 2021 Category: Research Authors: Razieh Dowran Mahyar Malekzadeh Tayyar Nourollahi Bahador Sarkari Jamal Sarvari Source Type: research

Prediction of Single-Nucleotide Polymorphisms within microRNAs Binding Sites of Neuronal Genes Related to Multiple Sclerosis: A Preliminary Study
CONCLUSIONS: These candidate MRE-SNPs can alter miRNAs binding sites and mRNA gene regulation. Therefore, these genetic variants and miRNAs might be involved in MS susceptibility and pathogenesis and hence would be valuable for further functional verification investigation.PMID:33959565 | PMC:PMC8095259 | DOI:10.4103/abr.abr_143_20 (Source: Biomed Res)
Source: Biomed Res - May 7, 2021 Category: Research Authors: Reyhaneh Dehghanzad Somayeh Panahi Moghadam Zeinab Shirvani Farsani Source Type: research

Effect of Mindfulness-Based Stress Reduction Program on Psychological Symptoms, Quality of Life, and Symptom Severity in Patients with Somatic Symptom Disorder
CONCLUSION: The MBSR accompanied by prescribing venlafaxine can significantly reduce the severity of SSD, as well as the number and severity of physical symptoms. Moreover, it can reduce depression, anxiety, stress, and their severity. The MBSR can be used as complementary medicine for the treatment of patients with SSD.PMID:33959566 | PMC:PMC8095256 | DOI:10.4103/abr.abr_111_19 (Source: Biomed Res)
Source: Biomed Res - May 7, 2021 Category: Research Authors: Fatemeh Zargar Leila Rahafrouz Mohammad Javad Tarrahi Source Type: research

The Effectiveness of Sternocleidomastoid Muscle Dry Needling in Patients with Cervicogenic Headache
This study was registered in Clinical Trials as IRCT20181109041599N1.RESULTS: One session DN into myofascial trigger points of the SCM muscle showed a significant improvement in HI (P
Source: Biomed Res - May 7, 2021 Category: Research Authors: Zahra Mohammadi Zohreh Shafizadegan Mohammad Javad Tarrahi Navid Taheri Source Type: research

CXCL1 Clone Evolution Induced by the HDAC Inhibitor Belinostat Might Be a Favorable Prognostic Indicator in Triple-Negative Breast Cancer
In this study, the GSE129944 microarray dataset from the Gene Expression Omnibus database was downloaded, and fold changes at the transcriptome level of a TNBC line (MDA-MB-231) after treatment with belinostat were identified. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were used to identify the critical biological processes. Construction and analysis of the protein-protein interaction (PPI) network were performed to screen candidate genes related to cancer prognosis. A total of 465 DEGs were identified, including 240 downregulated and 225 upregulated genes. The cytokin...
Source: Biomed Res - May 7, 2021 Category: Research Authors: Xin-le Han Jun Du Ya-Dan Zheng Jia-Jing Dai Su-Wen Lin Bing-Yue Zhang Fu-Bo Zhong Zhe-Guang Lin Shu-Qi Jiang Wei Wei Zheng-Yu Fang Source Type: research

Spleen Stiffness Performance in the Noninvasive Assessment of Gastroesophageal Varices after Transjugular Intrahepatic Portosystemic Shunts
CONCLUSION: SS is an effective noninvasive tool to predict GEV severity during the post-TIPS follow-up.PMID:33959657 | PMC:PMC8077793 | DOI:10.1155/2021/5530004 (Source: Biomed Res)
Source: Biomed Res - May 7, 2021 Category: Research Authors: Huihui Zhou Zhilin Zhang Jun Zhang Lin Sang Lina Liu Yong Lv Xue Gong Zhanxin Yin Yuanyuan Sun Guohong Han Ming Yu Source Type: research

Advances in the Development of Biomarkers for Poststroke Epilepsy
Biomed Res Int. 2021 Apr 17;2021:5567046. doi: 10.1155/2021/5567046. eCollection 2021.ABSTRACTStroke is the main cause of acquired epilepsy in elderly people. Poststroke epilepsy (PSE) not only affects functional recovery after stroke but also brings considerable social consequences. While some factors such as cortical involvement, hemorrhagic transformation, and stroke severity are associated with increased seizure risk, so far that remains controversial. In recent years, there are an increasing number of studies on potential biomarkers of PSE as tools for diagnosing and predicting epileptic seizures. Biomarkers such as i...
Source: Biomed Res - May 7, 2021 Category: Research Authors: Mengke Liang Liren Zhang Zhi Geng Source Type: research

Expression of miR-93-5p as a Potential Predictor of the Severity of Chronic Thromboembolic Pulmonary Hypertension
This study assessed the associations between the expression levels of these miRNAs and clinical parameters in CTEPH patients.METHODS: A total of eight CTEPH patients and eight healthy adults as a reference group were included, and clinical data including total protein (TP), albumin (Alb), lactate dehydrogenase (LDH), hydroxybutyrate dehydrogenase (HBDH), uric acid (UA), and N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels were collected. Right heart catheterization was conducted to obtain hemodynamic data including cardiac index (CI). The expression levels of let-7b-3p, miR-17-5p, miR-106b-5p, miR-3202, miR-665...
Source: Biomed Res - May 7, 2021 Category: Research Authors: Juanni Gong Yuanhua Yang Jianfeng Wang Yidan Li Xiaojuan Guo Qiang Huang Tuguang Kuang Suqiao Yang Jifeng Li Ran Miao Source Type: research

Intracranial Angioplasty with Enterprise Stent for Intracranial Atherosclerotic Stenosis: A Single-Center Experience and a Systematic Review
CONCLUSIONS: Intracranial angioplasty utilizing the Enterprise stent for ICAS treatment was relatively safe and effective but required further verification using additional sources for evidence.PMID:33959660 | PMC:PMC8075681 | DOI:10.1155/2021/6645500 (Source: Biomed Res)
Source: Biomed Res - May 7, 2021 Category: Research Authors: Bowen Sun Chao Xu Pei Wu Man Li Shancai Xu Chunlei Wang Xiangyu Liu Yeping Ling Huaizhang Shi Source Type: research

Transcriptome Analysis Reveals the Genes Involved in Growth and Metabolism in Muscovy Ducks
The objective of this study was to identify genes related to growth metabolism through transcriptome analysis of the ileal tissue of Muscovy ducks. Duck ileum samples with the highest (H group, n = 5) and lowest (L group, n = 5) body weight were selected from two hundred 70-day-old Muscovy ducks for transcriptome analysis by RNA sequencing. In the screening of differentially expressed genes (DEGs) between the H and L groups, a total of 602 DEGs with a fold change no less than 2 were identified, among which 285 were upregulated and 317 were downregulated. Gene Ontology (GO) enrichment analysis and Kyoto Encyclopedia of Gene...
Source: Biomed Res - May 7, 2021 Category: Research Authors: Xingxin Wang Yingping Xiao Hua Yang Lizhi Lu Xiuting Liu Wentao Lyu Source Type: research

Genes That Predict Poor Prognosis in Breast Cancer via Bioinformatical Analysis
CONCLUSION: These five genes (KIF4A, RACGAP1, CKS2, SHCBP1, and HMMR) could be potential targets for therapy in breast cancer and prediction of prognosis on the basis of bioinformatical analysis.PMID:33959662 | PMC:PMC8075678 | DOI:10.1155/2021/6649660 (Source: Biomed Res)
Source: Biomed Res - May 7, 2021 Category: Research Authors: Qian Zhou Xiaofeng Liu Mingming Lv Erhu Sun Xun Lu Cheng Lu Source Type: research

Comprehensive Analysis of Common Different Gene Expression Signatures in the Neutrophils of Sepsis
This study explored the possible molecular mechanisms underpinning the inflammatory, immune, and PI3K/AKT pathways related to sepsis development.PMID:33959663 | PMC:PMC8077712 | DOI:10.1155/2021/6655425 (Source: Biomed Res)
Source: Biomed Res - May 7, 2021 Category: Research Authors: Zhaojun Liu Yang Chen Tingting Pan Jialin Liu Rui Tian Shaoqiong Sun Hongping Qu Erzhen Chen Source Type: research

Comparison of Orthodontic Bracket Debonding Force and Bracket Failure Pattern on Different Teeth In Vivo by a Prototype Debonding Device
Biomed Res Int. 2021 Apr 17;2021:6663683. doi: 10.1155/2021/6663683. eCollection 2021.ABSTRACTOBJECTIVE: To compare the orthodontic bracket debonding force and assess the bracket failure pattern clinically between different teeth by a validated prototype debonding device. Materials and Method. Thirteen (13) patients at the end of comprehensive fixed orthodontic treatment, awaiting for bracket removal, were selected from the list. A total of 260 brackets from the central incisor to the second premolar in both jaws were debonded by a single clinician using a validated prototype debonding device equipped with a force sensitiv...
Source: Biomed Res - May 7, 2021 Category: Research Authors: Tamzid Ahmed Norma Ab Rahman Mohammad Khursheed Alam Source Type: research

Bilobalide Enhances AMPK Activity to Improve Liver Injury and Metabolic Disorders in STZ-Induced Diabetes in Immature Rats via Regulating HMGB1/TLR4/NF- < em > κ < /em > B Signaling Pathway
This study was aimed at examining the effect and underlying mechanisms of bilobalide (BB) on hepatic injury in streptozotocin- (STZ-) induced diabetes mellitus (DM) in immature rats. Immature rats (one day old) were randomly divided into five groups: group I, control nondiabetic rats; group II, STZ-induced, untreated diabetic rats; groups III/IV/V, STZ-induced and BB-treated diabetic rats, which were intraperitoneally injected with BB (2.5 mg/kg, 5 mg/kg, or 10 mg/kg) after 3 days followed by STZ treatment. We observed that BB improved the histopathological changes and maintained normal glucose metabolism, blood lipid, and...
Source: Biomed Res - May 7, 2021 Category: Research Authors: Meng Zhao Jianpin Qin Wenting Shen Aiping Wu Source Type: research

Whole-Exome Sequencing Identifies a Novel < em > TRPM4 < /em > Mutation in a Chinese Family with Atrioventricular Block
Biomed Res Int. 2021 Apr 17;2021:9247541. doi: 10.1155/2021/9247541. eCollection 2021.ABSTRACTAtrioventricular block (AVB) is a leading cause of sudden cardiac death, and most of AVB cases are presented as autosomal dominant. The electrocardiogram of AVB patients presents an abnormal progressive cardiac conduction disorder between atria and ventricles. Transient receptor potential melastatin 4 (TRPM4) is a nonselective Ca2+-activated cation channel gene defined as a novel disease-causing gene of AVB. So far, 47 mutations of TRPM4 have been recorded in Human Gene Mutation Database. The aim of this study was to explore the r...
Source: Biomed Res - May 7, 2021 Category: Research Authors: Yi Dong Ran Du Liang-Liang Fan Jie-Yuan Jin Hao Huang Ya-Qin Chen Dan-Dong Bi Rong Xiang Source Type: research

Biomimetic sponges improve muscle structure and function following volumetric muscle loss
In this study, biomimetic sponges composed of gelatin, collagen, laminin-111, and FK-506 were used for the treatment of VML in a rodent model. We observed that biomimetic sponge treatment improved muscle structure and function while modulating inflammation and limiting the extent of fibrotic tissue deposition. Specifically, sponge treatment increased the total number of myofibers, type 2B fiber cross-sectional area, myosin: collagen ratio, myofibers with central nuclei, and peak isometric torque compared to untreated VML injured muscles. As an acellular scaffold, biomimetic sponges may provide a promising clinical therapy ...
Source: Biomed Res - May 7, 2021 Category: Research Authors: Gabriel Haas Andrew Dunn Josh Madsen Peter Genovese Hannah Chauvin Jeffrey Au Natalia Ziemkiewicz David Johnson Allison Paoli Andrew Lin Nicholas Pullen Koyal Garg Source Type: research

Dendritic cells support a proliferative antigen-specific T-cell response in the presence of poly(lactic-co-glycolic acid)
This study elucidates the link between PLGA's effect on the DC phenotype in vitro and its adjuvant effect in vivo using the CD11c-DTR mouse model. These mice undergo conditional ablation of DCs upon treatment with diphtheria toxin. To measure immune activation, the mice were first given ovalbumin (OVA)-reactive T cells from OT-II/OT-I mice. Later, the same mice received subcutaneous OVA-loaded PLGA scaffold implants. In response to the scaffold implants, OVA-reactive OT-II CD4+ T cells showed decreased proliferation in the absence of CD11c+ DCs, indicating an attenuation of the PLGA-adjuvant effect. Furthermore, PLGA may a...
Source: Biomed Res - May 7, 2021 Category: Research Authors: Sangeetha Srinivasan Julia Elizabeth Babensee Source Type: research

Artificially altered gravity elicits cell homeostasis imbalance in planarian worms, and cerium oxide nanoparticles counteract this effect
J Biomed Mater Res A. 2021 May 7. doi: 10.1002/jbm.a.37215. Online ahead of print.ABSTRACTGravity alterations elicit complex and mostly detrimental effects on biological systems. Among these, a prominent role is occupied by oxidative stress, with consequences for tissue homeostasis and development. Studies in altered gravity are relevant for both Earth and space biomedicine, but their implementation using whole organisms is often troublesome. Here we utilize planarians, simple worm model for stem cell and regeneration biology, to characterize the pathogenic mechanisms brought by artificial gravity alterations. In particula...
Source: Biomed Res - May 7, 2021 Category: Research Authors: Alessandra Salvetti Andrea Degl'Innocenti Gaetana Gambino Jack J W A van Loon Chiara Ippolito Sandra Ghelardoni Eric Ghigo Luca Leoncino Mirko Prato Leonardo Rossi Gianni Ciofani Source Type: research

In vitro studies of Annona muricata L. extract-loaded electrospun scaffolds for localized treatment of breast cancer
J Biomed Mater Res B Appl Biomater. 2021 May 7. doi: 10.1002/jbm.b.34852. Online ahead of print.ABSTRACTThis paper presents in vitro studies of the sustained release of Annona muricata leaf extracts (AME) from hybrid electrospun fibers for breast cancer treatment. Electrospun hybrid scaffolds were fabricated from crude AME extracts, poly(lactic-co-glycolic acid)/gelatin (PLGA/Ge) and pluronic F127. The physicochemical properties of the AME extract and scaffolds were studied. The antiproliferative effects of the scaffolds were also assessed on breast cancer (MCF-7 and MDA-MB-231) and non-tumorigenic breast (MCF10A) cell lin...
Source: Biomed Res - May 7, 2021 Category: Research Authors: Udom M Akpan Michael Pellegrini Ali A Salifu John D Obayemi Theresa Ezenwafor Daniel Browe Chukwuemeka J Ani Yiporo Danyuo Stella Dozie-Nwachukwu Olushola S Odusanya Joseph Freeman Winston O Soboyejo Source Type: research

Utilization of GelMA with phosphate glass fibers for glial cell alignment
J Biomed Mater Res A. 2021 May 7. doi: 10.1002/jbm.a.37206. Online ahead of print.ABSTRACTGlial cell alignment in tissue engineered constructs is essential for achieving functional outcomes in neural recovery. While gelatin methacrylate (GelMA) hydrogel offers superior biocompatibility along with permissive structure and tailorable mechanical properties, phosphate glass fibers (PGFs) can provide physical cues for directionality of neural growth. Aligned PGFs were fabricated by a melt quenching and fiber drawing method and utilized with synthesized GelMA hydrogel. The mechanical properties of GelMA and biocompatibility of t...
Source: Biomed Res - May 7, 2021 Category: Research Authors: Zalike Keskin-Erdogan Kapil D Patel David Y S Chau Richard M Day Hae-Won Kim Jonathan C Knowles Source Type: research

The Circulating Midkine in the Newly Diagnosed Celiac Disease: Clinical Implications
CONCLUSIONS: The study results suggest that the MK marker does not have any diagnostic value in CeD activity to be used at the time of diagnosis or during follow-ups.PMID:33959558 | PMC:PMC8095258 | DOI:10.4103/abr.abr_8_20 (Source: Biomed Res)
Source: Biomed Res - May 7, 2021 Category: Research Authors: Mohammad Hassan Emami Shima Soltani Nahid Eskandari Mohsen Masjedi Source Type: research

Correlation between Stable Hyperglycemia and Mortality in Children Admitted to the Pediatric Intensive Care Unit of Imam Hossein Hospital
Adv Biomed Res. 2021 Jan 27;10:2. doi: 10.4103/abr.abr_31_20. eCollection 2021.ABSTRACTBACKGROUND: Stress-induced hyperglycemia is an important issue among pediatrics admitted in the pediatric intensive care unit (PICU). Former studies have declared that hyperglycemia has a high prevalence rate and could increase the risks of mortality among pediatrics. Here, we aimed to investigate the prevalence rate of hyperglycemia and its effects on mortality among pediatrics in the PICU of the hospital.MATERIALS AND METHODS: This cross-sectional study was performed in 2018-2019 on 88 patients admitted in PICU. Data regarding blood su...
Source: Biomed Res - May 7, 2021 Category: Research Authors: Mohsen Reisi Majid Keivanfar Neda Mostofizadeh Yahya Madihi Yousof Esmaeilian Elham Hashemi Source Type: research

Molecular Typing of Community-acquired Methicillin-Resistant < em > Staphylococcus aureus < /em > Isolated from 2- to 6-year old Children by Staphylococcal Protein A and < em > Agr < /em > Typing in Isfahan, Iran
CONCLUSIONS: The results of our study show that the rate of MRSA in our region is significantly high. Additionally, spa type t037 was the predominant type among CA S. aureus.PMID:33959560 | PMC:PMC8095255 | DOI:10.4103/abr.abr_139_20 (Source: Biomed Res)
Source: Biomed Res - May 7, 2021 Category: Research Authors: Sina Mobasherizadeh Hasan Shojaei Davood Azadi Seyed Asghar Havaei Behrooz Ataei Farzin Khorvash Source Type: research

Fabrication and Characterization of Glycerol/Chitosan/Polyvinyl Alcohol-Based Transparent Hydrogel Films Loaded with Silver Nanoparticles for Antibacterial Wound Dressing Applications
CONCLUSION: Our new fabricated dressing, glycerol/chitosan/PVA hydrogel loaded with AgNPs, exhibited satisfactory wound healing properties.PMID:33959561 | PMC:PMC8095260 | DOI:10.4103/abr.abr_211_20 (Source: Biomed Res)
Source: Biomed Res - May 7, 2021 Category: Research Authors: Ali Samadi Saeed Azandeh Mahmoud Orazizadeh Vahid Bayati Mohammad Rafienia Masoud Ali Karami Source Type: research

Report of a Case of Paraquat Poisoning and Mediastinal Involvement
Adv Biomed Res. 2021 Jan 27;10:5. doi: 10.4103/abr.abr_95_20. eCollection 2021.ABSTRACTParaquat has been recognized as a highly toxic agent for pest removal and is used worldwide. In adults, paraquat poisoning for suicidal attempts is much more common than accidental exposure poisoning. Approximately 20% of patients with paraquat poisoning develop pneumomediastonium as a complication with a mortality rate of approximately 100%. A 19-year-old man patient was admitted to the poisoning emergency department of Khorshid hospital, who had ingested paraquat. He had nausea and vomiting and had normal vital signs and examination in...
Source: Biomed Res - May 7, 2021 Category: Research Authors: Shiva Samsamshariat Amirhossein Vedaei Sharare Jahangiri Mahdi Badiee Gavarti Ramin Sami Abolfazl Taheri Gholamali Dorooshi Source Type: research

Human T-Cell Leukemia Virus Type 1 Changes Leukocyte Number and Oxidative Stress in the Lung and Blood of Female BALB/c Mice
Adv Biomed Res. 2021 Jan 30;10:6. doi: 10.4103/abr.abr_117_20. eCollection 2021.ABSTRACTBACKGROUND: Human T-cell leukemia virus type 1(HTLV-1) infection is likely to induce nonneoplastic inflammatory pulmonary diseases. Therefore, an experimental study was conducted to evaluate the leukocytes' number alteration and oxidative stress in the lung and blood of HTLV-1-infected BALB/c mice, which could be of benefit for the recognition of HTLV-1 mechanism in the induction of pulmonary disorders.MATERIALS AND METHODS: Twenty female BALB/c mice were divided into two groups of control and HTLV-1-infected animals. The HTLV-1-infecte...
Source: Biomed Res - May 7, 2021 Category: Research Authors: Mahdiyeh Hedayati-Moghadam S A Rahim Rezaee Mohammad Hossein Boskabady Nema Mohamadian Roshan Saeideh Saadat Kowsar Bavarsad Saeed Niazmand Source Type: research

The Prevalence of Hepatitis B Virus Markers among Students of Shiraz University of Medical Sciences
CONCLUSION: Findings of the current study show that more than half of the students do not have a protective level of anti-HBsAb and might be susceptible to HBV infection, indicating the necessity of checking the level of anti-HBsAb as well as a booster dose in high-risk groups.PMID:33959564 | PMC:PMC8095257 | DOI:10.4103/abr.abr_173_20 (Source: Biomed Res)
Source: Biomed Res - May 7, 2021 Category: Research Authors: Razieh Dowran Mahyar Malekzadeh Tayyar Nourollahi Bahador Sarkari Jamal Sarvari Source Type: research

Prediction of Single-Nucleotide Polymorphisms within microRNAs Binding Sites of Neuronal Genes Related to Multiple Sclerosis: A Preliminary Study
CONCLUSIONS: These candidate MRE-SNPs can alter miRNAs binding sites and mRNA gene regulation. Therefore, these genetic variants and miRNAs might be involved in MS susceptibility and pathogenesis and hence would be valuable for further functional verification investigation.PMID:33959565 | PMC:PMC8095259 | DOI:10.4103/abr.abr_143_20 (Source: Biomed Res)
Source: Biomed Res - May 7, 2021 Category: Research Authors: Reyhaneh Dehghanzad Somayeh Panahi Moghadam Zeinab Shirvani Farsani Source Type: research

Effect of Mindfulness-Based Stress Reduction Program on Psychological Symptoms, Quality of Life, and Symptom Severity in Patients with Somatic Symptom Disorder
CONCLUSION: The MBSR accompanied by prescribing venlafaxine can significantly reduce the severity of SSD, as well as the number and severity of physical symptoms. Moreover, it can reduce depression, anxiety, stress, and their severity. The MBSR can be used as complementary medicine for the treatment of patients with SSD.PMID:33959566 | PMC:PMC8095256 | DOI:10.4103/abr.abr_111_19 (Source: Biomed Res)
Source: Biomed Res - May 7, 2021 Category: Research Authors: Fatemeh Zargar Leila Rahafrouz Mohammad Javad Tarrahi Source Type: research

The Effectiveness of Sternocleidomastoid Muscle Dry Needling in Patients with Cervicogenic Headache
This study was registered in Clinical Trials as IRCT20181109041599N1.RESULTS: One session DN into myofascial trigger points of the SCM muscle showed a significant improvement in HI (P
Source: Biomed Res - May 7, 2021 Category: Research Authors: Zahra Mohammadi Zohreh Shafizadegan Mohammad Javad Tarrahi Navid Taheri Source Type: research

CXCL1 Clone Evolution Induced by the HDAC Inhibitor Belinostat Might Be a Favorable Prognostic Indicator in Triple-Negative Breast Cancer
In this study, the GSE129944 microarray dataset from the Gene Expression Omnibus database was downloaded, and fold changes at the transcriptome level of a TNBC line (MDA-MB-231) after treatment with belinostat were identified. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were used to identify the critical biological processes. Construction and analysis of the protein-protein interaction (PPI) network were performed to screen candidate genes related to cancer prognosis. A total of 465 DEGs were identified, including 240 downregulated and 225 upregulated genes. The cytokin...
Source: Biomed Res - May 7, 2021 Category: Research Authors: Xin-le Han Jun Du Ya-Dan Zheng Jia-Jing Dai Su-Wen Lin Bing-Yue Zhang Fu-Bo Zhong Zhe-Guang Lin Shu-Qi Jiang Wei Wei Zheng-Yu Fang Source Type: research

Spleen Stiffness Performance in the Noninvasive Assessment of Gastroesophageal Varices after Transjugular Intrahepatic Portosystemic Shunts
CONCLUSION: SS is an effective noninvasive tool to predict GEV severity during the post-TIPS follow-up.PMID:33959657 | PMC:PMC8077793 | DOI:10.1155/2021/5530004 (Source: Biomed Res)
Source: Biomed Res - May 7, 2021 Category: Research Authors: Huihui Zhou Zhilin Zhang Jun Zhang Lin Sang Lina Liu Yong Lv Xue Gong Zhanxin Yin Yuanyuan Sun Guohong Han Ming Yu Source Type: research

Advances in the Development of Biomarkers for Poststroke Epilepsy
Biomed Res Int. 2021 Apr 17;2021:5567046. doi: 10.1155/2021/5567046. eCollection 2021.ABSTRACTStroke is the main cause of acquired epilepsy in elderly people. Poststroke epilepsy (PSE) not only affects functional recovery after stroke but also brings considerable social consequences. While some factors such as cortical involvement, hemorrhagic transformation, and stroke severity are associated with increased seizure risk, so far that remains controversial. In recent years, there are an increasing number of studies on potential biomarkers of PSE as tools for diagnosing and predicting epileptic seizures. Biomarkers such as i...
Source: Biomed Res - May 7, 2021 Category: Research Authors: Mengke Liang Liren Zhang Zhi Geng Source Type: research

Expression of miR-93-5p as a Potential Predictor of the Severity of Chronic Thromboembolic Pulmonary Hypertension
This study assessed the associations between the expression levels of these miRNAs and clinical parameters in CTEPH patients.METHODS: A total of eight CTEPH patients and eight healthy adults as a reference group were included, and clinical data including total protein (TP), albumin (Alb), lactate dehydrogenase (LDH), hydroxybutyrate dehydrogenase (HBDH), uric acid (UA), and N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels were collected. Right heart catheterization was conducted to obtain hemodynamic data including cardiac index (CI). The expression levels of let-7b-3p, miR-17-5p, miR-106b-5p, miR-3202, miR-665...
Source: Biomed Res - May 7, 2021 Category: Research Authors: Juanni Gong Yuanhua Yang Jianfeng Wang Yidan Li Xiaojuan Guo Qiang Huang Tuguang Kuang Suqiao Yang Jifeng Li Ran Miao Source Type: research

Intracranial Angioplasty with Enterprise Stent for Intracranial Atherosclerotic Stenosis: A Single-Center Experience and a Systematic Review
CONCLUSIONS: Intracranial angioplasty utilizing the Enterprise stent for ICAS treatment was relatively safe and effective but required further verification using additional sources for evidence.PMID:33959660 | PMC:PMC8075681 | DOI:10.1155/2021/6645500 (Source: Biomed Res)
Source: Biomed Res - May 7, 2021 Category: Research Authors: Bowen Sun Chao Xu Pei Wu Man Li Shancai Xu Chunlei Wang Xiangyu Liu Yeping Ling Huaizhang Shi Source Type: research

Transcriptome Analysis Reveals the Genes Involved in Growth and Metabolism in Muscovy Ducks
The objective of this study was to identify genes related to growth metabolism through transcriptome analysis of the ileal tissue of Muscovy ducks. Duck ileum samples with the highest (H group, n = 5) and lowest (L group, n = 5) body weight were selected from two hundred 70-day-old Muscovy ducks for transcriptome analysis by RNA sequencing. In the screening of differentially expressed genes (DEGs) between the H and L groups, a total of 602 DEGs with a fold change no less than 2 were identified, among which 285 were upregulated and 317 were downregulated. Gene Ontology (GO) enrichment analysis and Kyoto Encyclopedia of Gene...
Source: Biomed Res - May 7, 2021 Category: Research Authors: Xingxin Wang Yingping Xiao Hua Yang Lizhi Lu Xiuting Liu Wentao Lyu Source Type: research

Genes That Predict Poor Prognosis in Breast Cancer via Bioinformatical Analysis
CONCLUSION: These five genes (KIF4A, RACGAP1, CKS2, SHCBP1, and HMMR) could be potential targets for therapy in breast cancer and prediction of prognosis on the basis of bioinformatical analysis.PMID:33959662 | PMC:PMC8075678 | DOI:10.1155/2021/6649660 (Source: Biomed Res)
Source: Biomed Res - May 7, 2021 Category: Research Authors: Qian Zhou Xiaofeng Liu Mingming Lv Erhu Sun Xun Lu Cheng Lu Source Type: research

Comprehensive Analysis of Common Different Gene Expression Signatures in the Neutrophils of Sepsis
This study explored the possible molecular mechanisms underpinning the inflammatory, immune, and PI3K/AKT pathways related to sepsis development.PMID:33959663 | PMC:PMC8077712 | DOI:10.1155/2021/6655425 (Source: Biomed Res)
Source: Biomed Res - May 7, 2021 Category: Research Authors: Zhaojun Liu Yang Chen Tingting Pan Jialin Liu Rui Tian Shaoqiong Sun Hongping Qu Erzhen Chen Source Type: research

Comparison of Orthodontic Bracket Debonding Force and Bracket Failure Pattern on Different Teeth In Vivo by a Prototype Debonding Device
Biomed Res Int. 2021 Apr 17;2021:6663683. doi: 10.1155/2021/6663683. eCollection 2021.ABSTRACTOBJECTIVE: To compare the orthodontic bracket debonding force and assess the bracket failure pattern clinically between different teeth by a validated prototype debonding device. Materials and Method. Thirteen (13) patients at the end of comprehensive fixed orthodontic treatment, awaiting for bracket removal, were selected from the list. A total of 260 brackets from the central incisor to the second premolar in both jaws were debonded by a single clinician using a validated prototype debonding device equipped with a force sensitiv...
Source: Biomed Res - May 7, 2021 Category: Research Authors: Tamzid Ahmed Norma Ab Rahman Mohammad Khursheed Alam Source Type: research