Reticuloendothelial System Pre-Block Strategy to Improve Tumor Targeting Efficacy for Hyaluronic Acid Related Drug Delivery System.
Abstract Hyaluronic acid (HA) is widely used in many tumor targeting drug delivery systems (TDDS) due to its biocompatibility and modifiability. Moreover, HA receptors are over-expressed on many tumor cells. However, the clearance of the HA-related TDDS by the reticuloendothelial system (RES) need urgent consideration on account of the high affinity between HA and related receptors in RES. A pre-block strategy before TDDS administration had been designed to overcome RES clearance. In order to avoid the rapid RES clearance and further improve tumor targeting efficiency for HA-related TDDS, we designed a novel strat...
Source: Biomed Res - July 27, 2018 Category: Research Authors: Liu F, Han L, Huang X, Sang M, Liu B, Li C, Ma C, Liu W, Feng F, Qu W Tags: J Biomed Nanotechnol Source Type: research

In Vivo Study of the Effects of ER β on Apoptosis and Proliferation of Hormone-Independent Prostate Cancer Cell Lines PC-3M.
In Vivo Study of the Effects of ERβ on Apoptosis and Proliferation of Hormone-Independent Prostate Cancer Cell Lines PC-3M. Biomed Res Int. 2018;2018:1439712 Authors: Zhou C, Yu C, Guo L, Wang X, Li H, Cao Q, Li F Abstract Objective: To evaluate the in vivo therapeutic effects of attenuated Salmonella carrying PCDNA3.1-ERβ plasmid in hormone-independent prostatic cancer in nude mice and to clarify the mechanism by which estrogen receptor β (ERβ) induces apoptosis and proliferation in prostatic cancer cells in mice. Methods: The orthotopic prostatic cancer models of mice were r...
Source: Biomed Res - July 20, 2018 Category: Research Authors: Zhou C, Yu C, Guo L, Wang X, Li H, Cao Q, Li F Tags: Biomed Res Int Source Type: research

Portable and Wearable Brain Technologies for Neuroenhancement and Neurorehabilitation.
PMID: 30018976 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - July 20, 2018 Category: Research Authors: Naseer N, Ayaz H, Dehais F Tags: Biomed Res Int Source Type: research

Pleurotus albidus Modulates Mitochondrial Metabolism Disrupted by Hyperglycaemia in EA.hy926 Endothelial Cells.
ola M Abstract Hyperglycaemia exacerbates the production of reactive oxygen species (ROS), contributing to the multiple complications associated with diabetes. Mitochondrial dysfunction is also known to be associated with diabetes. Therefore, the aim of this work was to study the effect of Pleurotus albidus extract on the mitochondrial dysfunction induced by hyperglycaemia in EA.hy926 endothelial cells. The results showed that P. albidus treatment prevented the increase in the activity of complex I of the electron transport chain and minimized the ROS production induced by hyperglycaemia. In addition, the extract ...
Source: Biomed Res - July 20, 2018 Category: Research Authors: Gambato G, Pavão EM, Chilanti G, Fontana RC, Salvador M, Camassola M Tags: Biomed Res Int Source Type: research

Effect of Multilaminate Small Intestinal Submucosa as a Barrier Membrane on Bone Formation in a Rabbit Mandible Defect Model.
In this study, we adopted multilaminate SIS (mSIS) as a BM and evaluated its in vivo and in vitro properties. mSIS exhibited a multilaminate structure with a smooth upper surface and a significantly coarser bottom layer according to microscopic observation. Tensile strength was 13.10 ± 2.56 MPa. In in vivo experiments, we selected a rabbit mandibular defect model and subcutaneous implantation to compare osteogenesis and biodegradation properties with one of the most commonly used commercial collagen membranes. mSIS was retained for up to 3 months and demonstrated longer biodegradation time than commercial collagen m...
Source: Biomed Res - July 20, 2018 Category: Research Authors: Wu W, Li B, Liu Y, Wang X, Tang L Tags: Biomed Res Int Source Type: research

Assessment of Disability and Factors Determining Disability among Inhabitants of South-Eastern Poland Aged 71-80 Years.
Conclusions: Measures intended to reduce the level of disability in older adults should focus on improving medical care, health education, increasing physical activity, adapting housing to the needs of everyday functioning, and providing daily help. PMID: 30018979 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - July 20, 2018 Category: Research Authors: Ćwirlej-Sozańska A, Sozański B, Wiśniowska-Szurlej A, Wilmowska-Pietruszyńska A, Kujawa J Tags: Biomed Res Int Source Type: research

Use of a Total Variation Minimization Iterative Reconstruction Algorithm to Evaluate Reduced Projections during Digital Breast Tomosynthesis.
Conclusions: The ASD-POCS algorithm can preserve contrast despite a reduced number of projections and could therefore be used to reduce radiation doses. PMID: 30018980 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - July 20, 2018 Category: Research Authors: Gomi T, Koibuchi Y Tags: Biomed Res Int Source Type: research

Insulin-Like Growth Factor-1 Signaling in Lung Development and Inflammatory Lung Diseases.
Abstract Insulin-like growth factor-1 (IGF-1) was firstly identified as a hormone that mediates the biological effects of growth hormone. Accumulating data have indicated the role of IGF-1 signaling pathway in lung development and diseases such as congenital disorders, cancers, inflammation, and fibrosis. IGF-1 signaling modulates the development and differentiation of many types of lung cells, including airway basal cells, club cells, alveolar epithelial cells, and fibroblasts. IGF-1 signaling deficiency results in alveolar hyperplasia in humans and disrupted lung architecture in animal models. The components of ...
Source: Biomed Res - July 20, 2018 Category: Research Authors: Wang Z, Li W, Guo Q, Wang Y, Ma L, Zhang X Tags: Biomed Res Int Source Type: research

Characteristic of HPV Integration in the Genome and Transcriptome of Cervical Cancer Tissues.
Abstract High-risk HPV is clearly associated with cervical cancer. HPV integration has been confirmed to promote carcinogenesis in the previous studies. In our study, a total of 285 DNA breakpoints and 287 RNA breakpoints were collected. We analyzed the characteristic of HPV integration in the DNA and RNA samples. The results revealed that the patterns of HPV integration in RNA and DNA samples differ significantly. FHIT, KLF5, and LINC00392 were the hotspot genes integrated by HPV in the DNA samples. RAD51B, CASC8, CASC21, ERBB2, TP63, TEX41, RAP2B, and MYC were the hotspot genes integrated by HPV in RNA samples. ...
Source: Biomed Res - July 20, 2018 Category: Research Authors: Li W, Qi Y, Cui X, Huo Q, Zhu L, Zhang A, Tan M, Hong Q, Yang Y, Zhang H, Liu C, Kong Q, Geng J, Tian Y, Kong F, Man D Tags: Biomed Res Int Source Type: research

The Central Neck Dissection or the Modified Sistrunk Procedure in the Treatment of the Thyroglossal Duct Cysts in Children: Our Experience.
Conclusions: A modified Sistrunk procedure is method of choice in the treatment of the uncomplicated TGDC. In selected cases of the TGDC with a history of infected cyst or incision of an abscess or in revision cases the central neck dissection should be considered in order to avoid the risk of the further recurrences. PMID: 30018983 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - July 20, 2018 Category: Research Authors: Pucher B, Jonczyk-Potoczna K, Kaluzna-Mlynarczyk A, Kurzawa P, Szydlowski J Tags: Biomed Res Int Source Type: research

LncRNA MEG3 enhances 131I sensitivity in thyroid carcinoma via sponging miR-182.
CONCLUSIONS: MEG3 enhanced the radiosensitivity of 131I in TC cells via sponging miR-182, indicating that MEG3 may act as a potential biomarker and therapeutic target for TC patients with 131I resistance. PMID: 30021359 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - July 20, 2018 Category: Research Authors: Liu Y, Yue P, Zhou T, Zhang F, Wang H, Chen X Tags: Biomed Pharmacother Source Type: research

Neuroprotective effect of Decalepis hamiltonii aqueous root extract and purified 2-hydroxy-4-methoxy benzaldehyde on 6-OHDA induced neurotoxicity in Caenorhabditis elegans.
In this study, we investigated the possible neuroprotective efficacy of Decalepis hamiltonii tuber extract against 6-Hydroxy dopamine (6-OHDA) induced neurotoxicity and associated effects in Caenorhabditis elegans. The major component of flavour rich extract from D. hamiltonii is 2-hydroxy-4-methoxy benzaldehyde (2H4MB) which is an isomer of vanillin. We have conducted preliminary experiments with different types of extracts and subsequently DHFE (D. hamiltonii Fresh Tuber Extract) and DHPF (D. hamiltonii purified 2H4MB fraction) were used for further studies. Here we attempted to enumerate the neuroprotective efficacy of ...
Source: Biomed Res - July 20, 2018 Category: Research Authors: Kamireddy K, Chinnu S, Priyanka PS, Rajini PS, Giridhar P Tags: Biomed Pharmacother Source Type: research

Enhancing Epitranscriptome Module Detection from m6A-Seq Data Using Threshold-Based Measurement Weighting Strategy.
eng J Abstract To date, with well over 100 different types of RNA modifications associated with various molecular functions identified on diverse types of RNA molecules, the epitranscriptome has emerged to be an important layer for gene expression regulation. It is of crucial importance and increasing interest to understand how the epitranscriptome is regulated to facilitate different biological functions from a global perspective, which may be carried forward by finding biologically meaningful epitranscriptome modules that respond to upstream epitranscriptome regulators and lead to downstream biological functions...
Source: Biomed Res - July 19, 2018 Category: Research Authors: Chen K, Wei Z, Liu H, de Magalhães JP, Rong R, Lu Z, Meng J Tags: Biomed Res Int Source Type: research

Effect of Chronic Kidney Disease on Changes in Vasopressin System Expression in the Kidney Cortex in Rats with Nephrectomy.
Abstract It is believed that the vasopressinergic system plays an important role in the pathogenesis of chronic kidney disease (CKD). The aim of this study was to evaluate the effect of CKD on changes in vasopressin system expression in the kidney cortex in rats with nephrectomy. The study was performed on 4 groups of Sprague Dawley (SPRD) rats: a control group (CN), 1/2 nephrectomy (N1/2), 2/3 nephrectomy (N2/3), and 5/6 nephrectomy (N5/6). Blood and the kidney cortex were collected to evaluate plasma copeptin concentrations and mRNA expressions of V1a vasopressin receptors (V1aR) and V2 vasopressin receptors (V2...
Source: Biomed Res - July 19, 2018 Category: Research Authors: Czarzasta K, Cudnoch-Jedrzejewska A, Niemczyk L, Wrzesien R, Tkaczyk M, Puchalska L, Saracyn M, Zmudzki W, Niemczyk S Tags: Biomed Res Int Source Type: research

The Associations between Biochemical and Microbiological Variables and Taste Differ in Whole Saliva and in the Film Lining the Tongue.
The objective of this work was to investigate whether the biological film lining the tongue may play a role in taste perception. For that purpose, the tongue film and saliva of 21 healthy subjects were characterized, focusing on microorganisms and their main metabolic substrates and products. In parallel, taste sensitivity was evaluated using a test recently developed by our group, and the links between biological and sensory data were explored by a correlative approach. Saliva and tongue film differed significantly in biochemical composition (proportions of glucose, fructose, sucrose, and lactic, butyric, and acetic acids...
Source: Biomed Res - July 19, 2018 Category: Research Authors: Feng Y, Licandro H, Martin C, Septier C, Zhao M, Neyraud E, Morzel M Tags: Biomed Res Int Source Type: research

Advances and Challenges at the Waste-to-Bioenergy/Biorefinery Nexus.
PMID: 30013982 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - July 19, 2018 Category: Research Authors: Ge S, Usack J, Ma B Tags: Biomed Res Int Source Type: research

16S rRNA Long-Read Sequencing of the Granulation Tissue from Nonsmokers and Smokers-Severe Chronic Periodontitis Patients.
Abstract Smoking has been associated with increased risk of periodontitis. The aim of the present study was to compare the periodontal disease severity among smokers and nonsmokers which may help in better understanding of predisposition to this chronic inflammation mediated diseases. We selected deep-seated infected granulation tissue removed during periodontal flap surgery procedures for identification and differential abundance of residential bacterial species among smokers and nonsmokers through long-read sequencing technology targeting full-length 16S rRNA gene. A total of 8 phyla were identified among which ...
Source: Biomed Res - July 19, 2018 Category: Research Authors: Chowdhry R, Singh N, Sahu DK, Tripathi RK, Mishra A, Singh A, Shyam H, Shankar P, Lal N, Bhatt MLB, Kant R Tags: Biomed Res Int Source Type: research

Serum Folate Correlates with Severity of Guillain-Barr é Syndrome and Predicts Disease Progression.
Serum Folate Correlates with Severity of Guillain-Barré Syndrome and Predicts Disease Progression. Biomed Res Int. 2018;2018:5703279 Authors: Gao Y, Zhang HL, Xin M, Wang D, Zheng N, Wang S, Xu J, Wang Y, Zhu J, Feng J Abstract The aim of this study was to determine the associations between serum folate level and the clinical course and severity of Guillain-Barré syndrome (GBS). We retrospectively enrolled 112 pairs of GBS patients and age- and sex-matched healthy controls with measured serum folate levels. On admission, 21 (18.9%) GBS patients had folate deficiency, of which only two we...
Source: Biomed Res - July 19, 2018 Category: Research Authors: Gao Y, Zhang HL, Xin M, Wang D, Zheng N, Wang S, Xu J, Wang Y, Zhu J, Feng J Tags: Biomed Res Int Source Type: research

Microbiota Composition in Upper Respiratory Tracts of Healthy Children in Shenzhen, China, Differed with Respiratory Sites and Ages.
In this study, we performed a 16S rDNA gene sequencing analysis of 83 anterior nares (ANs), 60 nasopharynx (NP), and 97 oropharynx (OP) samples from 98 healthy children in Shenzhen, China (≤12 years of age). The microbiota in ANs and NP is the same at different ages and typical species in these sites include Moraxella, Staphylococcus, Corynebacterium, Streptococcus, and Dolosigranulum. By contrast, the OP is primarily colonized by Streptococcus, Prevotella, Neisseria, Veillonella, Rothia, Leptotrichia, and Haemophilus. Streptococcus and Rothia keep low abundance in OP microbiota of children ≤1 year old, whereas Prevo...
Source: Biomed Res - July 19, 2018 Category: Research Authors: Wang H, Dai W, Feng X, Zhou Q, Wang H, Yang Y, Li S, Zheng Y Tags: Biomed Res Int Source Type: research

Localization of Glucose Transporter 10 to Hair Cells' Cuticular Plate in the Mouse Inner Ear.
This study aimed to investigate the localization pattern of glucose transporters (Gluts) in mouse cochlea. Genome-wide gene expression analysis using CodeLink™ bioarrays indicated that Glut1 and Glut10 were highly expressed (~10-fold) in mouse cochlea compared with the other members of glucose transporters (Glut2-6, Glut8, and Glut9). Semiquantitative RT-PCR and western blotting confirmed that Glut10 expression in mouse cochlea was high throughout the embryogenesis and postnatal development. Immunofluorescent staining showed that Glut10 protein was localized in the cuticular plate of the outer and inner cochlear hair...
Source: Biomed Res - July 19, 2018 Category: Research Authors: Chen B, Wang Y, Geng M, Lin X, Tang W Tags: Biomed Res Int Source Type: research

Association between VEGF Gene Polymorphisms and the Susceptibility to Lung Cancer: An Updated Meta-Analysis.
Conclusions: VEGF +936C/T, -460C/T, and -2578C/A polymorphisms were not associated with the risk of lung cancer. The VEGF +460T/C polymorphism might be a risk factor for lung cancer only in Asian populations. PMID: 30013987 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - July 19, 2018 Category: Research Authors: Yang F, Qin Z, Shao C, Liu W, Ma L, Shu Y, Shen H Tags: Biomed Res Int Source Type: research

Numerical Evaluation and Prediction of Porous Implant Design and Flow Performance.
This study investigates effect of aimed-control design on mass transfer and tissue regeneration of porous implant with regular unit cell. Two shapes of unit cells (Octet truss, and Rhombic dodecahedron) were selected, which have similar symmetrical structure and are commonly used in practice. Through parametric design, porous scaffolds with the strut sizes of φ 0.5, 0.7, 0.9, and 1.1mm were created, respectively. Then using fluid flow simulation method, flow velocity, permeability, and shear stress which could reflect the properties of mass transfer and tissue regeneration were compared and evaluated, and the relations...
Source: Biomed Res - July 17, 2018 Category: Research Authors: Li J, Chen D, Luan H, Zhang Y, Fan Y Tags: Biomed Res Int Source Type: research

Reliability and Concurrent Validity of a Chinese Version of the Alberta Infant Motor Scale Administered to High-Risk Infants in China.
Abstract The Alberta Infant Motor Scale (AIMS) is widely used to screen for delays in motor development in high-risk infants, but its reliability and validity in Chinese infants have not been investigated. To examine the reliability and concurrent validity of AIMS in high-risk infants aged 0-9 months in China, this single-center study enrolled 50 high-risk infants aged 0-9 months (range, 0.17-9.27; average, 4.14±2.02), who were divided into two groups: 0-3 months (n=23) and 4-9 months (n=27). A physical therapist evaluated the infants with AIMS, with each evaluation video-recorded. To examine interrater rel...
Source: Biomed Res - July 17, 2018 Category: Research Authors: Wang H, Li H, Wang J, Jin H Tags: Biomed Res Int Source Type: research

Could Prolonged Usage of GPS Navigation Implemented in Augmented Reality Smart Glasses Affect Hippocampal Functional Connectivity?
This study aimed to assess possible changes in functional connectivity (FC) of hippocampus and other brain regions involved in spatial navigation. Methods: Thirty-three healthy participants completed two resting state functional magnetic resonance imaging (rsfMRI) measurements at the baseline and after 3 months. For this period, the experimental group (n = 17) has had used AR device (Vuzix M100) with incorporated GPS guidance system during navigation in real world. Participants from the control group (n = 16) have not used any GPS device while navigating during walking. The rsfMRI FC of right and left hippocampi was a...
Source: Biomed Res - July 17, 2018 Category: Research Authors: Fajnerová I, Greguš D, Hlinka J, Nekovářová T, Škoch A, Zítka T, Romportl J, Žáčková E, Horáček J Tags: Biomed Res Int Source Type: research

Identification of Feline Interferon Regulatory Factor 1 as an Efficient Antiviral Factor against the Replication of Feline Calicivirus and Other Feline Viruses.
Abstract Interferons (IFNs) can inhibit most, if not all, viral infections by eliciting the transcription of hundreds of interferon-stimulated genes (ISGs). Feline calicivirus (FCV) is a highly contagious pathogen of cats and a surrogate for Norwalk virus. Interferon efficiently inhibits the replication of FCV, but the mechanism of the antiviral activity is poorly understood. Here, we evaluated the anti-FCV activity of ten ISGs, whose antiviral activities were previously reported. The results showed that interferon regulatory factor 1 (IRF1) can significantly inhibit the replication of FCV, whereas the other ISGs ...
Source: Biomed Res - July 17, 2018 Category: Research Authors: Liu Y, Liu X, Kang H, Hu X, Liu J, Tian J, Qu L Tags: Biomed Res Int Source Type: research

CD4+CD45RA-FOXP3low Regulatory T Cells as Potential Biomarkers of Disease Activity in Systemic Lupus Erythematosus Brazilian Patients.
MGR Abstract Heren, we analyzed Treg cells as potential biomarkers of disease activity in systemic lupus erythematosus (SLE) patients. Peripheral blood mononuclear cells from 30 SLE patients (15 active: SLEDAI> 6/15 SLE remission: SLEDAI
Source: Biomed Res - July 17, 2018 Category: Research Authors: Silva-Neta HL, Brelaz-de-Castro MCA, Chagas MBO, Mariz HA, de Arruda RG, de Vasconcelos VF, Pereira MC, Romano A, Pitta IR, Marques CDL, Duarte ALBP, Rêgo MJBM, Pitta MGR Tags: Biomed Res Int Source Type: research

Prevalence and Risk Factors of MRI Abnormality Which Was Suspected as Sinusitis in Japanese Middle-Aged and Elderly Community Dwellers.
Abstract The aims of this study were to determine the prevalence of MRI abnormalities which were suspected as sinusitis in community-dwelling middle-aged and elderly Japanese and to identify risk factors for the MRI abnormality. Brain magnetic resonance imaging (MRI) data from the National Institute for Longevity Sciences, Longitudinal Study of Aging (NILS-LSA) were used for the analysis. Among the 2330 subjects in the NILS-LSA, 1933 participants were categorized as having no MRI abnormality or MRI abnormality using the Lund-Mackay (LM) score. The mean LM score of the participants was 0.88±1.92, and 144 (7....
Source: Biomed Res - July 17, 2018 Category: Research Authors: Sugiura S, Yasue M, Uchida Y, Teranishi M, Sone M, Suzuki H, Nakashima T, Otsuka R, Ando F, Shimokata H Tags: Biomed Res Int Source Type: research

The Signaling Pathways Involved in the Antiatherosclerotic Effects Produced by Chinese Herbal Medicines.
Abstract Cardiovascular diseases (CVDs) are considered to be the predominant cause of death in the world. Chinese herb medicines (CHMs) have been widely used for the treatment of CVDs in Asian countries for thousands of years. One reason of high efficacy of CHMs in treating CVDs is attributed to their inhibition in atherosclerosis (AS) development, a critical contributor to CVDs occurrence. Cumulative studies have demonstrated that CHMs alleviate atherogenesis via mediating pathophysiologic events involved in AS. However, there is deficiency in the summaries regarding antiatherogenic signal pathways regulated by C...
Source: Biomed Res - July 17, 2018 Category: Research Authors: Lu L, Sun X, Qin Y, Guo X Tags: Biomed Res Int Source Type: research

Synovial Fluid Aspiration Should Not Be Routinely Performed during the Two-Stage Exchange of the Knee.
Conclusion: The detection of infection persistence remains challenging and a consented approach is lacking. The results do not warrant the routine performance of SFC during the two-stage exchange at the knee. SWBCC can be used to confirm infection persistence at high cut-offs, but they only occur in few patients and are therefore inappropriate for the routine use. PMID: 30009171 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - July 17, 2018 Category: Research Authors: Boelch SP, Roth M, Arnholdt J, Rudert M, Luedemann M Tags: Biomed Res Int Source Type: research

Use of a Radiomics Model to Predict Tumor Invasiveness of Pulmonary Adenocarcinomas Appearing as Pulmonary Ground-Glass Nodules.
Abstract Background: It is important to distinguish the classification of lung adenocarcinoma. A radiomics model was developed to predict tumor invasiveness using quantitative and qualitative features of pulmonary ground-glass nodules (GGNs) on chest CT. Materials and Methods: A total of 599 GGNs [including 202 preinvasive lesions and 397 minimally invasive and invasive pulmonary adenocarcinomas (IPAs)] were evaluated using univariate, multivariate, and logistic regression analyses to construct a radiomics model that predicted invasiveness of GGNs. In primary cohort (comprised of patients scanned from August ...
Source: Biomed Res - July 17, 2018 Category: Research Authors: Xue X, Yang Y, Huang Q, Cui F, Lian Y, Zhang S, Yao L, Peng W, Li X, Pang P, Yan J, Chen F Tags: Biomed Res Int Source Type: research

Association between HLA-DP Gene Polymorphisms and Cervical Cancer Risk: A Meta-Analysis.
Conclusion. HLA-DP gene polymorphisms (HLA-DPB1⁎03:01, DPB1⁎04:02, DPB1⁎13:01, rs9277535, and rs3117027) were significantly associated with cervical cancer. PMID: 30009173 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - July 17, 2018 Category: Research Authors: Cheng L, Guo Y, Zhan S, Xia P Tags: Biomed Res Int Source Type: research

Indicators of Data Quality at the Cancer Registry Zurich and Zug in Switzerland.
Abstract Data quality is an important issue in cancer registration. This paper provides a comprehensive overview of the four main data quality indicators (comparability, validity, timeliness, and completeness) for the Cancer Registry Zurich and Zug (Switzerland). We extracted all malignant cancer cases (excluding non-melanoma skin cancer) diagnosed between 1980 and 2014 in the canton of Zurich. Methods included the proportion of morphologically verified cases (MV%), the proportion of DCN and DCO cases (2009-2014), cases with primary site uncertain (PSU%), the stability of incidence rates over time, age-specific in...
Source: Biomed Res - July 17, 2018 Category: Research Authors: Wanner M, Matthes KL, Korol D, Dehler S, Rohrmann S Tags: Biomed Res Int Source Type: research

Potential of Gene and Cell Therapy for Inner Ear Hair Cells.
Abstract Sensorineural hearing loss is caused by the loss of sensory hair cells (HCs) or a damaged afferent nerve pathway to the auditory cortex. The most common option for the treatment of sensorineural hearing loss is hearing rehabilitation using hearing devices. Various kinds of hearing devices are available but, despite recent advancements, their perceived sound quality does not mimic that of the "naïve" cochlea. Damage to crucial cochlear structures is mostly irreversible and results in permanent hearing loss. Cochlear HC regeneration has long been an important goal in the field of hearing rese...
Source: Biomed Res - July 17, 2018 Category: Research Authors: Lee MY, Park YH Tags: Biomed Res Int Source Type: research

Chitosan Tubes Enriched with Fresh Skeletal Muscle Fibers for Primary Nerve Repair.
In this study we show a simple strategy to improve the performance of a chitosan hollow tube by the introduction of fresh skeletal muscle fibers. The hypothesis is to overcome the technical issue of the muscle-in-vein preparation and to take advantage of fiber muscle properties to create an easy and effective conduit for nerve regeneration. Rat median nerve gaps were repaired with chitosan tubes filled with skeletal muscle fibers (muscle-in-tube graft), hollow chitosan tubes, or autologous nerve grafts. Our results demonstrate that the fresh skeletal muscle inside the conduit is an endogenous source of soluble Neuregulin 1...
Source: Biomed Res - July 17, 2018 Category: Research Authors: Ronchi G, Fornasari BE, Crosio A, Budau CA, Tos P, Perroteau I, Battiston B, Geuna S, Raimondo S, Gambarotta G Tags: Biomed Res Int Source Type: research

Bone Response to Titanium Implants Coated with Double- or Single-Stranded DNA.
Abstract We aimed to evaluate in vivo bone response and in vitro apatite formation to titanium (Ti) implants, coated with double-stranded DNA (DNA-d) or single-stranded DNA (DNA-s), and to compare the influence in different structure of DNA, double strand and single strand on bone response and apatite formation. The bone responses to multilayered DNA-d/protamine or DNA-s/protamine coating implants were evaluated after implantation into the extracted sockets of rat maxillary molars. Apatite formation on either coating surface after immersion in simulated body fluid (SBF) was evaluated using the quartz crystal micro...
Source: Biomed Res - July 17, 2018 Category: Research Authors: Miyamoto N, Yamachika R, Sakurai T, Hayakawa T, Hosoya N Tags: Biomed Res Int Source Type: research

Resistant Gram-Negative Bacteria and Diagnostic Point-of-Care Options for the Field Setting during Military Operations.
Abstract The spread of multidrug-resistant bacteria in resource-poor settings affects the military medical service in case of deployments of soldiers to war and crisis zones. Patients with war injuries are prone to colonization or infection with multidrug-resistant bacteria. Resistant Gram-negative bacteria play a dominant role in military wound infections. Problematic hygiene conditions on deployment facilitate exposition of soldiers with subsequent colonization. Although colonizing strains are frequently cleared from their hosts after returning from deployment, transmission to close contacts of the soldiers in t...
Source: Biomed Res - July 17, 2018 Category: Research Authors: Frickmann H, Podbielski A, Kreikemeyer B Tags: Biomed Res Int Source Type: research

Students' Motivation for Sport Activity and Participation in University Sports: A Mixed-Methods Study.
This study investigates reasons for sport engagement among students and addresses the utilization of university sports programs (USP) by employing a mixed-methods approach. Methods: The NuPhA-Study consists of a quantitative online survey (n=689) followed by qualitative interviews (n=20). In the survey, we assessed reasons for sport activity using a 24-item battery and USP utilization. Quantitative results were further explored using qualitative data to check for completeness of the predefined items (content validity) and to identify opportunities to improve participating in USP. Results: A factor analysis groupe...
Source: Biomed Res - July 17, 2018 Category: Research Authors: Diehl K, Fuchs AK, Rathmann K, Hilger-Kolb J Tags: Biomed Res Int Source Type: research

Gender Dysphoria: Bioethical Aspects of Medical Treatment.
Abstract Gender affirmation surgery remains one of the greatest challenges in transgender medicine. In recent years, there have been continuous discussions on bioethical aspects in the treatment of persons with gender dysphoria. Gender reassignment is a difficult process, including not only hormonal treatment with possible surgery but also social discrimination and stigma. There is a great variety between countries in specified tasks involved in gender reassignment, and a complex combination of medical treatment and legal paperwork is required in most cases. The most frequent bioethical questions in transgender me...
Source: Biomed Res - July 17, 2018 Category: Research Authors: Bizic MR, Jeftovic M, Pusica S, Stojanovic B, Duisin D, Vujovic S, Rakic V, Djordjevic ML Tags: Biomed Res Int Source Type: research

Direct Intrahepatic Portocaval Shunt for Sinusoidal Obstruction Syndrome Associated with Hepatotoxicity of Pyrrolizidine Alkaloids.
Abstract We retrospectively identified 89 consecutive patients from January 2004 to January 2012 to investigate efficacy of direct intrahepatic portocaval shunt (DIPS) combined with inferior vena cava (IVC) stenting for sinusoidal obstruction syndrome (SOS) associated with hepatotoxicity of pyrrolizidine alkaloids. Indications for treatment were variceal hemorrhage and/or refractory ascites. Patients were treated with DIPS plus IVC stenting (group A, n=68) or DIPS alone (group B, n=21). A technical success rate of 100% was obtained in all 89 patients, and there were no early procedure-related adverse events or 30-...
Source: Biomed Res - July 17, 2018 Category: Research Authors: Luo S, Chu J, Huang H, Yao K Tags: Biomed Res Int Source Type: research

Isolation of a Reassortant H1N2 Swine Flu Strain of Type "Swine-Human-Avian" and Its Genetic Variability Analysis.
Isolation of a Reassortant H1N2 Swine Flu Strain of Type "Swine-Human-Avian" and Its Genetic Variability Analysis. Biomed Res Int. 2018;2018:1096079 Authors: Wang LB, Chen QY, Wu XM, Che YL, Wang CY, Chen RJ, Zhou LJ Abstract We isolated an influenza strain named A/Swine/Fujian/F1/2010 (H1N2) from a pig suspected to be infected with swine flu. The results of electron microscopy, hemagglutination (HA) assay, hemagglutination inhibition (HI) assay, and whole genome sequencing analysis suggest that it was a reassortant virus of swine (H1N1 subtype), human (H3N2 subtype), and avian influenza vir...
Source: Biomed Res - July 14, 2018 Category: Research Authors: Wang LB, Chen QY, Wu XM, Che YL, Wang CY, Chen RJ, Zhou LJ Tags: Biomed Res Int Source Type: research

Selected Enzyme Inhibitory Effects of Euphorbia characias Extracts.
Abstract Extracts of aerial part of Euphorbia characias were examined to check potential inhibitors for three selected enzymes involved in several metabolic disorders. Water and ethanol extracts from leaves and flowers showed in vitro inhibitory activity toward α-amylase, α-glucosidase, and xanthine oxidase. IC50 values were calculated for all the extracts and the ethanolic extracts were found to exert the best effect. In particular, for the α-glucosidase activity, the extracts resulted to be 100-fold more active than the standard inhibitor. The inhibition mode was investigated by Lineweaver-Burk...
Source: Biomed Res - July 14, 2018 Category: Research Authors: Fais A, Era B, Di Petrillo A, Floris S, Piano D, Montoro P, Tuberoso CIG, Medda R, Pintus F Tags: Biomed Res Int Source Type: research

Genetic Polymorphism Study on Aedes albopictus of Different Geographical Regions Based on DNA Barcoding.
In conclusion, DNA barcoding of MT-COI gene is an effective method to study the genetic structure of Aedes albopictus. PMID: 30003088 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - July 14, 2018 Category: Research Authors: Fang Y, Zhang J, Wu R, Xue B, Qian Q, Gao B Tags: Biomed Res Int Source Type: research

Advantages of Graphene Biosensors for Human Stem Cell Therapy Potency Assays.
Abstract Regenerative medicine is challenged by the need to conform to rigorous guidelines for establishing safe and effective development and translation of stem cell-based therapies. Counteracting widespread concerns regarding unproven cell therapies, stringent cell-based assays seek not only to avoid harm but also to enhance quality and efficacy. Potency indicates that the cells are functionally fit for purpose before they are administered to the patient. It is a paramount quantitative critical quality attribute serving as a decisive release criterion. Given a broad range of stem cell types and therapeutic cont...
Source: Biomed Res - July 14, 2018 Category: Research Authors: Amărandi RM, Becheru DF, Vlăsceanu GM, Ioniță M, Burns JS Tags: Biomed Res Int Source Type: research

Assessment the Bond Strength of Ceramic Brackets to CAD/CAM Nanoceramic Composite and Interpenetrating Network Composite after Different Surface Treatments.
In conclusion, different surface treatments affect the shear bond strength of ceramic brackets to CAD/CAM interpenetrating network composite and nanoceramic composite. Among the evaluated treatments, sandblasting and hydrofluoric acid application resulted in sufficient bonding strength to ceramic brackets for both of the CAD/CAM materials. PMID: 30003090 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - July 14, 2018 Category: Research Authors: Özarslan MM, Üstün Ö, Buyukkaplan US, Barutcigil Ç, Türker N, Barutcigil K Tags: Biomed Res Int Source Type: research

First Report of Seroprevalence and Risk Factors of Neospora caninum Infection in Tibetan Sheep in China.
Abstract Neospora caninum is an intracellular protozoan parasite which can cause abortion and stillbirth in ruminants. However, there is no information on Tibetan sheep N. caninum infection in China. A total of 2187 serum samples were collected from Tibetan sheep in the major production areas of Luqu, Maqu, and Tianzhu in Gansu province, and Nyingchi in southeast Tibet, China. All samples were analyzed for the presence of antibodies to N. caninum using a competitive-inhibition enzyme-linked immunoassay. Of the 2187 serum samples, 184 (8.4%, 95% CI 7.3-9.6) were tested N. caninum seropositive. The N. caninum seropr...
Source: Biomed Res - July 14, 2018 Category: Research Authors: Nie LB, Cong W, Zou Y, Zhou DH, Liang QL, Zheng WB, Ma JG, Du R, Zhu XQ Tags: Biomed Res Int Source Type: research

Use of Quantitative Morphological and Functional Features for Assessment of Axillary Lymph Node in Breast Dynamic Contrast-Enhanced Magnetic Resonance Imaging.
Conclusions: Compactness as morphological feature and area under time-intensity curve as dynamic feature were the best parameters in identifying metastatic lymph nodes on breast MRI. PMID: 30003092 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - July 14, 2018 Category: Research Authors: Fusco R, Sansone M, Granata V, Di Bonito M, Avino F, Catalano O, Botti G, Petrillo A Tags: Biomed Res Int Source Type: research

A Novel Heterozygous Intronic Mutation in the FBN1 Gene Contributes to FBN1 RNA Missplicing Events in the Marfan Syndrome.
Abstract Marfan syndrome (MFS) is an autosomal dominantly inherited connective tissue disorder, mostly caused by mutations in the fibrillin-1 (FBN1) gene. We, by using targeted next-generation sequence analysis, identified a novel intronic FBN1 mutation (the c.2678-15C>A variant) in a MFS patient with aortic dilatation. The computational predictions showed that the heterozygous c.2678-15C>A intronic variant might influence the splicing process by differentially affecting canonical versus cryptic splice site utilization within intron 22 of the FBN1 gene. RT-PCR and Western blot analyses, using FBN1 minigenes ...
Source: Biomed Res - July 14, 2018 Category: Research Authors: Torrado M, Maneiro E, Trujillo-Quintero JP, Evangelista A, Mikhailov AT, Monserrat L Tags: Biomed Res Int Source Type: research

The Transcription Factor ATF4 Promotes Expression of Cell Stress Genes and Cardiomyocyte Death in a Cellular Model of Atrial Fibrillation.
Conclusion: ATF4 is expressed in human atrial cardiomyocytes and is induced in response to different types of cell stress. High rate electrical field stimulation seems to result in ATF4 induction, and forced expression of ATF4 reduces cardiomyocyte viability. PMID: 30003094 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - July 14, 2018 Category: Research Authors: Freundt JK, Frommeyer G, Wötzel F, Huge A, Hoffmeier A, Martens S, Eckardt L, Lange PS Tags: Biomed Res Int Source Type: research

Magnetic Resonance Imaging Findings in the Muscle Tissue of Patients with Limb Girdle Muscular Dystrophy Type 2I Harboring the Founder Mutation c.545A > G in the FKRP Gene.
Magnetic Resonance Imaging Findings in the Muscle Tissue of Patients with Limb Girdle Muscular Dystrophy Type 2I Harboring the Founder Mutation c.545A>G in the FKRP Gene. Biomed Res Int. 2018;2018:3710814 Authors: Xie Z, Xiao J, Zheng Y, Wang Z, Yuan Y Abstract Limb girdle muscular dystrophy type 2I (LGMD2I) is an autosomal recessive muscular dystrophy that is rare in Asia and is caused by mutations in the fukutin-related protein gene (FKRP). The aim of this study was to determine if there are any characteristic features of muscle on magnetic resonance imaging (MRI) in patients with LGMD2I harborin...
Source: Biomed Res - July 14, 2018 Category: Research Authors: Xie Z, Xiao J, Zheng Y, Wang Z, Yuan Y Tags: Biomed Res Int Source Type: research

Risk Factors Related to Peripherally Inserted Central Venous Catheter Nonselective Removal in Neonates.
Abstract We aimed to investigate the incidence and risk factors associated with nonselective removal of peripherally inserted central venous catheter (PICC) in neonates. In this prospective cohort study, neonates who underwent PICC placement at neonatal intensive care units (NICUs) in China from October 2012 to November 2015 were included. The patient demographics, catheter characteristics, catheter duration, PICC insertion site, indication for PICC insertion, infuscate composition, PICC tip location, and catheter complications were recorded in a computerized database. Risk factors for nonselective removal were an...
Source: Biomed Res - July 14, 2018 Category: Research Authors: Yu X, Yue S, Wang M, Cao C, Liao Z, Ding Y, Huang J, Li W Tags: Biomed Res Int Source Type: research