Possible Role of Cyclic AMP Response Element Binding/Brain-Derived Neurotrophic Factor Signaling Pathway in Mediating the Pharmacological Effects of Duloxetine against Methamphetamine Use-Induced Cognitive Impairment and Withdrawal-Induced Anxiety and Depression in Rats.
Conclusions: Duloxetine can protect the brain against methamphetamine withdrawal-induced mood and motor disturbances and can also inhibit methamphetamine-induced cognitive impairment, possibly via cAMP/CREB/BDNF signaling pathway. PMID: 30993081 [PubMed] (Source: Biomed Res)
Source: Biomed Res - April 18, 2019 Category: Research Authors: Ramezany Yasuj S, Nourhashemi M, Keshavarzi S, Motaghinejad M, Motevalian M Tags: Adv Biomed Res Source Type: research

The Prevalence of Complications of Prematurity among 1000 Newborns in Isfahan, Iran.
Abstract Background: Different morbidity conditions are globally reported from different nations for premature infants. The aim of this study was to identify the relative frequency of some of the most important complications of prematurity in a population of about 1000 of very low birth weight (VLBW; i.e., infants with weight of
Source: Biomed Res - April 18, 2019 Category: Research Authors: Armanian AM, Barekatain B, Sohrabi F, Salehimehr N, Mansourian M Tags: Adv Biomed Res Source Type: research

Comparative Evaluation of Therapeutic Approaches to Central Sleep Apnea.
Conclusion: The results suggest that CPAP and BIPAP are, respectively, the most effective therapeutic approaches to CSA in patients with the histories of HF and opioid use, but CPAP + O2 could be reliable in some conditions as well. Therefore, it may require further studies to be clarified. PMID: 30993083 [PubMed] (Source: Biomed Res)
Source: Biomed Res - April 18, 2019 Category: Research Authors: Sadeghi Y, Sedaghat M, Majedi MA, Pakzad B, Ghaderi A, Raeisi A Tags: Adv Biomed Res Source Type: research

Assessment of the Early and Late Complication after Thyroidectomy.
Conclusions: According to the results of this study, the high level of surgeon's skill is effective to reduce the likelihood of late and early complications; furthermore, the chance of late complications increases with age. PMID: 30993084 [PubMed] (Source: Biomed Res)
Source: Biomed Res - April 18, 2019 Category: Research Authors: Chahardahmasumi E, Salehidoost R, Amini M, Aminorroaya A, Rezvanian H, Kachooei A, Iraj B, Nazem M, Kolahdoozan M Tags: Adv Biomed Res Source Type: research

The Interaction of Helicobacter pylori Infection and Type 2 Diabetes Mellitus.
Abstract Helicobacter pylori is one of the most common human pathogens that can cause gastrointestinal (GI) disorders, including simple gastritis, gastric ulcer, and malignant gastritis. In some cases, such as immunodeficiency and underlying diseases, it can be problematic as opportunistic infections. Diabetes mellitus (type 2) (T2DM) is one of the H. pylori underlying diseases. Since GI problems are observed in diabetic patients, it is necessary to treat H. pylori infection. In this review, we aimed to evaluate the possible relationship between H. pylori and T2DM according to epidemiological surveys of 70 studies...
Source: Biomed Res - April 18, 2019 Category: Research Authors: Hosseininasab Nodoushan SA, Nabavi A Tags: Adv Biomed Res Source Type: research

Relationship between Resistin, Endothelin-1, and Flow-Mediated Dilation in Patient with and without Metabolic Syndrome.
Conclusion: In this study, results shown plasma ET-1 and resistin are suggested as risk factors for the development of endothelial dysfunction and with further study, it is possible that can diagnose the risk of diabetes and cardiovascular disease in the early stages. PMID: 30993086 [PubMed] (Source: Biomed Res)
Source: Biomed Res - April 18, 2019 Category: Research Authors: Samsamshariat SZA, Sakhaei F, Salehizadeh L, Keshvari M, Asgary S Tags: Adv Biomed Res Source Type: research

Comparing the Efficacy of Two Drugs Senalin and Bisacodyl in Treatment of Constipation in Intensive Care Units' Patients.
Abstract Background: Constipation is an intestinal syndrome that can be created alone or in the context of another disease in patients admitted to intensive care units (ICUs). Given the role of sennosides in increasing the transfer rate of materials from the large intestine, we aimed to compare the effect of senalin with bisacodyl on the treatment of constipation in patients admitted to ICUs. Materials and Methods: In this randomized, double-blind study, 70 patients admitted to the ICU were divided into two groups. The senalin recipient group received senalin with a dose of 500 mg daily for 3 days. The bisaco...
Source: Biomed Res - April 18, 2019 Category: Research Authors: Alikiaii B, Majedi MA, Hashemi ST, Kiani M Tags: Adv Biomed Res Source Type: research

Prostate-Specific Membrane Antigen Expression in Neovasculature of Glioblastoma Multiforme.
Conclusion: The expression of PSMA in GBM, as observed in the current study, may suggest a new role of PSMA-targeted therapy and indicate more investigations focused on complementary treatment strategies that specifically target tumor vasculature. PMID: 30993088 [PubMed] (Source: Biomed Res)
Source: Biomed Res - April 18, 2019 Category: Research Authors: Mahzouni P, Shavakhi M Tags: Adv Biomed Res Source Type: research

Bax Targeted by miR-29a Regulates Chondrocyte Apoptosis in Osteoarthritis.
Abstract Osteoarthritis (OA) is a chronic degenerative joint disease, where chondrocyte apoptosis is responsible for cartilage degeneration. Bax is a well-known proapoptotic protein of the Bcl-2 family, involved in a large number of physiological and pathological processes. However, the regulation mechanisms of Bax underlying chondrocyte apoptosis in OA remain unknown. In the present study, we determined the role of Bax in human OA and chondrocyte apoptosis. The results showed that Bax was upregulated in chondrocytes from the articular cartilage of OA patients and in cultured chondrocyte-like ATDC5 cells treated b...
Source: Biomed Res - April 18, 2019 Category: Research Authors: Miao G, Zang X, Hou H, Sun H, Wang L, Zhang T, Tan Y, Liu W, Ye P, Gao L, Zha Z Tags: Biomed Res Int Source Type: research

Chemical and Bioactivity Evaluation of Eryngium planum and Cnicus benedictus Polyphenolic-Rich Extracts.
This study evaluated the biological activities of Eryngium planum and of Cnicus benedictus extracts enriched in polyphenols obtained by nanofiltration. The HPLC-MS analysis showed that E. planum contains mainly flavonoids, especially rutin, while in C. benedictus extracts show the high concentration of the phenolic acids, principally the chlorogenic acid and sinapic acid. Herein, there is the first report of ursolic acid, genistin, and isorhamnetin in E. planum and C. benedictus. C. benedictus polyphenolic-rich extract showed high scavenging activity (IC50=0.0081 mg/mL) comparable to that of standard compound (ascorbic aci...
Source: Biomed Res - April 18, 2019 Category: Research Authors: Paun G, Neagu E, Moroeanu V, Albu C, Savin S, Lucian Radu G Tags: Biomed Res Int Source Type: research

Telmisartan Attenuates Uric Acid-Induced Epithelial-Mesenchymal Transition in Renal Tubular Cells.
In conclusion, telmisartan could ameliorate uric acid-induced EMT in NRK-52E cells likely through inhibition of the NADPH oxidase/ERK1/2/ET-1 pathway. PMID: 30993112 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - April 18, 2019 Category: Research Authors: Zha D, Wu S, Gao P, Wu X Tags: Biomed Res Int Source Type: research

Potential Regulatory Effects of miR-182-3p in Osteosarcoma via Targeting EBF2.
Abstract Osteosarcoma (OS) is one of the most common primary malignant bone tumors in adolescents with a high mortality rate. MicroRNA (miRNA) is a kind of noncoding RNAs and has been proved to participate in many physiological processes. Many miRNAs have been reported to act as function regulators in OS. In our study, the miRNA and gene expression profiles of OS were downloaded from GEO Datasets and the differential expression analysis was performed using GEO2R. 58 up- and 126 downregulated miRNAs were found. In the three OS gene profiles, 125 up- and 27 downregulated genes were found to be differentially express...
Source: Biomed Res - April 18, 2019 Category: Research Authors: Chen G, Yu W, Li Z, Wang Q, Yang Q, Du Z, Zhang G, Song Y Tags: Biomed Res Int Source Type: research

Association of Kiss1 and GPR54 Gene Polymorphisms with Polycystic Ovary Syndrome among Sri Lankan Women.
Abstract Polycystic ovary syndrome (PCOS) is the commonest endocrine disorder affecting women of reproductive age. Its aetiology, though yet unclear, is presumed to have an oligogenic basis interacting with environmental factors. Kisspeptins are peptide products of Kiss1 gene that control the hypothalamic pituitary (HPG) axis by acting via G protein-coupled receptor known as GPR54. There is paucity of data on the role of Kiss1 and GPR54 gene in PCOS. We aimed to identify the polymorphisms in Kiss1 and GPR54 genes and explore their association with serum kisspeptin levels among Sri Lankan women with well-characteri...
Source: Biomed Res - April 18, 2019 Category: Research Authors: Branavan U, Muneeswaran K, Wijesundera WSS, Senanayake A, Chandrasekharan NV, Wijeyaratne CN Tags: Biomed Res Int Source Type: research

Dynamic changes in basal lamina fenestrations in rat intestinal villous epithelium under high-fat diet condition.
Abstract The basal lamina of the villous epithelium in the small intestine has numerous fenestrations, which are produced by leukocytes for their intraepithelial migration. We previously showed that these fenestrations change due to the dynamics of migrating leukocytes in response to dietary conditions and suggested the possibility that this change is related to the regulation of the absorption of large-sized nutrients such as chylomicrons. The present study was, thus, designed to investigate structural changes in basal lamina fenestrations in response to a high-fat diet. The ultrastructure of the intestinal villi...
Source: Biomed Res - April 17, 2019 Category: Research Authors: Morita K, Azumi R, Sato M, Mizutani Y, Hayatsu M, Terai S, Ushiki T Tags: Biomed Res Source Type: research

Kr üppel-like factor 5 (Klf5) regulates expression of mouse T1R1 amino acid receptor gene (Tas1r1) in C2C12 myoblast cells.
Krüppel-like factor 5 (Klf5) regulates expression of mouse T1R1 amino acid receptor gene (Tas1r1) in C2C12 myoblast cells. Biomed Res. 2019;40(2):67-78 Authors: Hirata Y, Toyono T, Kokabu S, Obikane Y, Kataoka S, Nakatomi M, Masaki C, Hosokawa R, Seta Y Abstract T1R1 and T1R3 are receptors expressed in taste buds that detect L-amino acids. These receptors are also expressed throughout diverse organ systems, such as the digestive system and muscle tissue, and are thought to function as amino acid sensors. The mechanism of transcriptional regulation of the mouse T1R1 gene (Tas1r1) has not been dete...
Source: Biomed Res - April 17, 2019 Category: Research Authors: Hirata Y, Toyono T, Kokabu S, Obikane Y, Kataoka S, Nakatomi M, Masaki C, Hosokawa R, Seta Y Tags: Biomed Res Source Type: research

Bush-like integrin filament networks associated with hyaloid vasculature in murine neonate eyes.
Abstract The vitreous of perinatal mice temporarily develops a unique vascular system, called the vasa hyaloidea propria (VHP). Observations showed the vessels possessed an extracellular matrix including the basement membrane in their entire length. Immunostaining of whole mount preparations of VHP with integrin β1 antibody displayed a bush-like network consisting of long and straight fibers which were associated with the VHP but extended apart from the blood vessels. Electron microscopically, each fiber was composed of a bundle of thin filaments different from collagen fibrils. Macrophages associated with th...
Source: Biomed Res - April 17, 2019 Category: Research Authors: Iwanaga T, Nio-Kobayashi J, Takahashi-Iwanaga H Tags: Biomed Res Source Type: research

Neutralizing antibodies for Helicobacter pylori urease inhibit bacterial colonization in the murine stomach in vivo.
Abstract Helicobacter pylori (H. pylori) urease is a key protein for persistent infection of the bacteria in the stomach. Although H. pylori generally induce anti-H. pylori-specific antibodies (Abs), these Abs do not usually work for eradication or prevention of the H. pylori infection. In our previous study, we identified a linear epitope composed of 19-mer peptides termed UB-33, CHHLDKSIKEDVQFADSRI, within the large subunit of H. pylori urease. Anti-UB-33-specific Abs neutralized the enzymatic activity of H. pylori urease in vitro. In the present study, we evaluated the effect of immunization of BALB/c mice with...
Source: Biomed Res - April 17, 2019 Category: Research Authors: Takeshita H, Watanabe E, Norose Y, Ito Y, Takahashi H Tags: Biomed Res Source Type: research

Combined Activation of Guanylate Cyclase and Cyclic AMP in Lung Fibroblasts as a Novel Therapeutic Concept for Lung Fibrosis.
This study investigated the effect of BAY 41-2272 and forskolin on remodelling parameters in primary human lung fibroblasts. The study determined TGF-β induced proliferation by direct cell counts after 3 days; and deposition of collagen type-I, type III, and fibronectin. BAY 41-2272 significantly reduced TGF-β induced fibroblast proliferation, but did not reduce viability. This inhibitory effect was further supported by forskolin. Both BAY 41-2272 and forskolin alone reduced TGF-β induced collagen and fibronectin de novo synthesis as well as deposition. This effect was significantly stronger when the two com...
Source: Biomed Res - April 17, 2019 Category: Research Authors: Lambers C, Boehm PM, Karabacak Y, Samaha E, Benazzo A, Jaksch P, Roth M Tags: Biomed Res Int Source Type: research

Value of 3D Preoperative Planning for Primary Total Hip Arthroplasty Based on Biplanar Weightbearing Radiographs.
ard D Abstract Two-dimensional (2D) planning on standard radiographs for total hip arthroplasty may not be sufficiently accurate to predict implant sizing or restore leg length and femoral offset, whereas 3D planning avoids magnification and projection errors. Furthermore, weightbearing measures are not available with computed tomography (CT) and leg length and offset are rarely checked postoperatively using any imaging modality. Navigation can usually achieve a surgical plan precisely, but the choice of that plan remains key, which is best guided by preoperative planning. The study objectives were therefore to (1...
Source: Biomed Res - April 17, 2019 Category: Research Authors: Knafo Y, Houfani F, Zaharia B, Egrise F, Clerc-Urmès I, Mainard D Tags: Biomed Res Int Source Type: research

Quantitative Proteomic Analysis of Human Seminal Plasma from Normozoospermic and Asthenozoospermic Individuals.
Abstract Seminal plasma is a complex mixture of secretions from various glands in the male genital tract. Compared to sperm cells, it contains important proteins that are both directly and indirectly associated with sperm motility. Here, we constructed quantitative proteomes of human seminal plasma from three normozoospermic and asthenozoospermic individuals. A total of 524 proteins were identified, and 366 of them were found to be quantified in all six samples. We first investigated the absolute expression features of these proteins and found that the variations of protein identification among different samples a...
Source: Biomed Res - April 17, 2019 Category: Research Authors: Wu Y, Yuan Y, Chen L, Wang M, Yang Y, Wang Y, Quan C, Chen D, Chen Y, Huang X, Zhou T Tags: Biomed Res Int Source Type: research

Efficacy of a Methanolic Extract of Adansonia digitata Leaf in Alleviating Hyperglycemia, Hyperlipidemia, and Oxidative Stress of Diabetic Rats.
Abstract Traditionally, in many countries, various parts of the Adansonia digitata (A. digitata) tree have been used in the treatment of many clinical ailments including diarrhea and dysentery. The phytochemical screening has indicated that the leaf extract of A. digitata contains flavonoids, saponins, mucilage, steroids, and alkaloids. Thus, this paper aims to evaluate the hyperglycaemic and hypolipidaemic effects of methanolic extract of A. digitata leaves (200 mg/kg and 400 mg/kg) in diabetic rats. The extract was administered orally for six weeks in the streptozotocin (STZ)-induced diabetic rats. The treatment...
Source: Biomed Res - April 17, 2019 Category: Research Authors: Ebaid H, Bashandy SAE, Alhazza IM, Hassan I, Al-Tamimi J Tags: Biomed Res Int Source Type: research

Etifoxine, a TSPO Ligand, Worsens Hepatitis C-Related Insulin Resistance but Relieves Lipid Accumulation.
Abstract Etifoxine, an 18 kDa translocator protein (TSPO) agonist for the treatment of anxiety disorders in clinic, may be able to cause acute liver injury or cytolytic hepatitis. TSPO has been demonstrated to participate in inflammatory responses in infective diseases as well as to modulate glucose and lipid homeostasis. Hepatitis C virus (HCV) infection disrupts glucose and lipid homoeostasis, leading to insulin resistance (IR). Whether TSPO affects the HCV-induced IR remains unclear. Here, we found that the administration of etifoxine increased the TSPO protein expression and recovered the HCV-mediated lower mi...
Source: Biomed Res - April 17, 2019 Category: Research Authors: Lin YM, Sun HY, Chiu WT, Su HC, Chien YC, Chang HA, Chong LW, Chang HC, Young KC, Bai CH, Tsao CW Tags: Biomed Res Int Source Type: research

Extensive Use of 3D Nonfluoroscopic Mapping Systems for Reducing Radiation Exposure during Catheter Ablation Procedures: An Analysis of 10 Years of Activity.
Conclusions: Our study shows the feasibility of using NMSs as the main imaging modality to guide CA. The extended, routine use of NMSs dramatically reduces radiation exposure, with only slight fluctuations due to the process of acquiring experience on the part of untrained operators, without affecting disease-free survival. PMID: 30984780 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - April 17, 2019 Category: Research Authors: Marini M, Martin M, Ravanelli D, Del Greco M, Quintarelli S, Guarracini F, Coser A, Valentini A, Bonmassari R Tags: Biomed Res Int Source Type: research

Reversing Effect of Insulin on Local Anesthetics-Induced Sciatic Nerve Block in Rats.
Abstract Background: Local anesthetics are used in various purposes from topical and infiltration anesthesia to peripheral nerve or central neural blockade. Even though local anesthetics are relatively safe, they can have some toxic and adverse effects. Prolonged sensory and motor block is another example of an unwanted complication. The primary objective of this study was to determine whether insulin has a reversal effect on the peripheral (sciatic) nerve block with lidocaine or bupivacaine. Methods: The surgically exposed sciatic nerves in rats were blocked with lidocaine or bupivacaine, and then 0.1&thinsp...
Source: Biomed Res - April 17, 2019 Category: Research Authors: Kim JM, Choi SH Tags: Biomed Res Int Source Type: research

SNP Typing Using Multiplex Real-Time PCR Assay for Species Identification of Forensically Important Blowflies and Fleshflies Collected in South Korea (Diptera: Calliphoridae and Sarcophagidae).
Abstract Medicolegal entomology-a subfield of forensic entomology-is mainly used in medicolegal investigations to estimate the postmortem interval (PMI). The minimum PMI of a corpse invaded by necrophagous immature insects can be estimated because the PMI is near to or earlier than the oviposition time of the larvae that hatched and fed on the corpse. As the growth speeds of larvae differ depending on temperature and species, species-specific growth data are used to estimate the minimum PMI. While morphological identification of adult necrophagous flies can be done by a well-trained entomologist, identification of...
Source: Biomed Res - April 17, 2019 Category: Research Authors: Jang H, Shin SE, Ko KS, Park SH Tags: Biomed Res Int Source Type: research

Retracted: Influence of Two Common Polymorphisms in the EPHX1 Gene on Warfarin Maintenance Dosage: A Meta-Analysis.
Abstract [This retracts the article DOI: 10.1155/2015/564149.]. PMID: 30984783 [PubMed] (Source: Biomed Res)
Source: Biomed Res - April 17, 2019 Category: Research Authors: BioMed Research International Tags: Biomed Res Int Source Type: research

Correlation between Testicular Hemodynamic and Semen Quality Indices in Clinical Varicocele Patients in Pakistan.
Abstract Varicocele, a vascular event, is associated with infertility due to testicular damage that causes abnormal spermatogenesis in males. The goal of this study is to ascertain the diagnostic significance of scrotal color Doppler ultrasonography (CDUS) by measuring peak systolic value (PSV) and resistive index (RI) of the arteries supplying blood to the testis and their association with semen quality attributes. Sixty prospective patients (age: 20-50 years) undergoing microsurgical varicocelectomy at a teaching hospital were included in the study. Semen parameters and CDUS were recorded and testicular blood fl...
Source: Biomed Res - April 17, 2019 Category: Research Authors: Rehman KU, Zaneb H, Qureshi AB, Yousaf MS, Numan A, Majeed KA, Rabbani I, Khan TM, Rehman H Tags: Biomed Res Int Source Type: research

Corrigendum to "Potential of Gene and Cell Therapy for Inner Ear Hair Cells".
Corrigendum to "Potential of Gene and Cell Therapy for Inner Ear Hair Cells". Biomed Res Int. 2019;2019:9601260 Authors: Lee MY, Park YH Abstract [This corrects the article DOI: 10.1155/2018/8137614.]. PMID: 30984785 [PubMed] (Source: Biomed Res)
Source: Biomed Res - April 17, 2019 Category: Research Authors: Lee MY, Park YH Tags: Biomed Res Int Source Type: research

Association between Gamma-Glutamyl Transferase and Coronary Atherosclerotic Plaque Vulnerability: An Optical Coherence Tomography Study.
Abstract Background: Gamma-glutamyl transferase (GGT) has been detected in coronary plaques. However, the association between serum GGT levels and coronary atherosclerotic plaque vulnerability in patients with coronary artery disease (CAD) as detected by optical coherence tomography (OCT) has not been investigated. Methods: We performed a retrospective study of consecutively enrolled CAD patients undergoing preintervention OCT examination during coronary angiography. Plaque vulnerability was defined as the presence of ruptured plaques or thin-cap fibroatheroma (TCFA) upon OCT. The association between serum GG...
Source: Biomed Res - April 17, 2019 Category: Research Authors: Wang J, Li X, Pu J, Jin S, Jia L, Li X, Liu F, Shan C, Yang Y Tags: Biomed Res Int Source Type: research

Corrigendum to "Old and New NICE Guidelines for the Evaluation of New Onset Stable Chest Pain: A Real World Perspective".
Corrigendum to "Old and New NICE Guidelines for the Evaluation of New Onset Stable Chest Pain: A Real World Perspective". Biomed Res Int. 2019;2019:9637490 Authors: Carrabba N, Migliorini A, Pradella S, Acquafresca M, Guglielmo M, Baggiano A, Muscogiuri G, Valenti R Abstract [This corrects the article DOI: 10.1155/2018/3762305.]. PMID: 30984787 [PubMed] (Source: Biomed Res)
Source: Biomed Res - April 17, 2019 Category: Research Authors: Carrabba N, Migliorini A, Pradella S, Acquafresca M, Guglielmo M, Baggiano A, Muscogiuri G, Valenti R Tags: Biomed Res Int Source Type: research

Low Expression of hsa_circ_0018069 in Human Bladder Cancer and Its Clinical Significance.
Abstract Abnormal expression of noncoding RNA molecules such as circRNA plays an important role in the development of malignant tumors. circRNAs are stable in structure and can be useful as ideal tumor markers. Advanced bladder cancer has poor treatment options and prognosis. Thus, we examined circRNAs to further understand the pathogenesis and development of bladder cancer and to identify molecular markers for the early diagnosis of bladder carcinoma. We found that hsa_circ_0018069 was differentially expressed in our RNA sequencing data. We used qRT-PCR to detect its expression in T24 and Biu-87 cell lines and in...
Source: Biomed Res - April 17, 2019 Category: Research Authors: Li M, Wang Y, Liu Y, Zhang X, Liu J, Wang P Tags: Biomed Res Int Source Type: research

Bone Marrow Derived Mesenchymal Stromal Cells Ameliorate Ischemia/Reperfusion Injury-Induced Acute Kidney Injury in Rats via Secreting Tumor Necrosis Factor-Inducible Gene 6 Protein.
Abstract Aims: To investigate whether bone marrow derived mesenchymal stromal cells (BMSC) have ameliorated ischemia/reperfusion injury-induced acute kidney injury (IRI-AKI) via tumor necrosis factor-inducible gene 6 protein (TSG-6) and how TSG-6 exerted this effect. Methods: We used lentiviral vectors of short hairpin RNA (shRNA) targeting TSG-6 gene to silence TSG-6 in BMSC. And TSG-6-silenced BMSC were administrated into IRI-AKI rats. Then we analyzed serum creatinine (Scr) and renal histology of IRI-AKI rats treated with BMSC after different pretreatments. Furthermore, we explored the effect of TSG-6 on r...
Source: Biomed Res - April 17, 2019 Category: Research Authors: Chen Y, Tang X, Li P, Zhou Y, Xue T, Liu J, Yu C Tags: Biomed Res Int Source Type: research

Human Umbilical Cord-derived Scaffolds for Cartilage Tissue Engineering.
In conclusion, it is confirmed that umbilical cord-derived scaffolds are able to provide a native environment for the cells and can promote cartilage differentiation. This article is protected by copyright. All rights reserved. PMID: 30983084 [PubMed - as supplied by publisher] (Source: Biomed Res)
Source: Biomed Res - April 15, 2019 Category: Research Authors: Safari F, Fani N, Eglin D, Alini M, Stoddart MJ, Baghaban Eslaminejad M Tags: J Biomed Mater Res A Source Type: research

Enhanced Adhesion of Plasma-Sprayed Commercially Pure Titanium Porous Coatings to Polished Mg-PSZ Ceramic Substrates.
This article is protected by copyright. All rights reserved. PMID: 30983085 [PubMed - as supplied by publisher] (Source: Biomed Res)
Source: Biomed Res - April 14, 2019 Category: Research Authors: Tilden DS, Roy ME, Whiteside LA Tags: J Biomed Mater Res A Source Type: research

Biocompatibility and immunogenic response to recombinant honeybee silk material.
This article is protected by copyright. All rights reserved. PMID: 30983124 [PubMed - as supplied by publisher] (Source: Biomed Res)
Source: Biomed Res - April 14, 2019 Category: Research Authors: Sutherland TD, Vashi AV, Kardia E, Sriskantha A, Rapson TD, Hall RN, Werkmeister JA Tags: J Biomed Mater Res A Source Type: research

Modification of human MSC surface with oligopeptide-PEG-lipids for selective binding to activated endothelium.
Abstract Promising cell therapies using mesenchymal stem cells (MSCs) is proposed for stroke patients. Therefore, we aimed to efficiently accumulate human MSC (hMSC) to damaged brain area to improve the therapeutic effect using poly(ethylene glycol) (PEG)-conjugated phospholipid (PEG-lipid) carrying an oligopeptide as a ligand, specific for E-selectin which is up-regulated on activated endothelial cells under hypoxia like stroke. Here we synthesized E-selectin-binding oligopeptide (ES-bp) conjugated with PEG spacer having different molecular weights from 1 kDa to 40 kDa. We found that ES-bp can be immobilized onto...
Source: Biomed Res - April 14, 2019 Category: Research Authors: Noiri M, Asawa K, Okada N, Kodama T, Murayama Y, Inoue Y, Ishihara K, Ekdahl KN, Nilsson B, Teramura Y Tags: J Biomed Mater Res A Source Type: research

Evaluation of in vitro cytotoxicity and properties of polydimethylsiloxane-based polyurethane/crystalline nanocellulose bio-nanocomposites.
This article is protected by copyright. All rights reserved. PMID: 30983129 [PubMed - as supplied by publisher] (Source: Biomed Res)
Source: Biomed Res - April 14, 2019 Category: Research Authors: Khadivi P, Salami-Kalajahi M, Roghani-Mamaqani H Tags: J Biomed Mater Res A Source Type: research

First clinical application of octacalcium phosphate collagen composite on bone regeneration in maxillary sinus floor augmentation: A prospective, single-arm, open-label clinical trial.
Abstract The overall objective of this study was to assess the safety and efficacy of OCP/Col as a bone substitute material for bone regeneration during sinus floor augmentation. Maxillary sinus floor augmentation was performed thorough lateral window approach. According to the height of host bone, simultaneous approach (≥5 mm) or staged approach (less than 5 mm) was applied. In this research, clinical findings of dental implant treatment after setting the restorations were set as a primary endpoint in both approaches (infection, inflammation around the implant, movement of the implant, pain, sensory disorder, ...
Source: Biomed Res - April 13, 2019 Category: Research Authors: Miura KI, Sumita Y, Kajii F, Tanaka H, Kamakura S, Asahina I Tags: J Biomed Mater Res B Appl Biomater Source Type: research

Particle analysis of shape factors according to American Society for Testing and Materials.
In this study, three different software solutions for particle analysis (self-developed Particleanalyzer_HD, Leica QWin and ImageJ) were compared regarding particle number, size and morphology. These solutions were also compared to the American Society for Testing and Materials (ASTM) F1877-16 specifications regarding particle morphology. SEM image analysis revealed no differences for the equivalent circle diameter (p = 0.969). However, a significant difference was found for the aspect ratio between the Particleanalyzer_HD and the other two software solutions (p
Source: Biomed Res - April 12, 2019 Category: Research Authors: Schroeder S, Braun S, Mueller U, Sonntag R, Jaeger S, Kretzer JP Tags: J Biomed Mater Res B Appl Biomater Source Type: research

Mussel adhesive protein fused with VE-cadherin extracellular domain promotes endothelial-cell tight junctions and in vivo endothelization recovery of vascular stent.
In this study, using stent implants coated with VE-M, we evaluated the clinical applicability of VE-M in endothelialization recovery in vivo. First, we explored the effect of VE-M on hemocompatibility and tight junctions between endothelial cells (ECs) in vitro. VE-M significantly inhibited platelet adhesion and promoted EC proliferation. Furthermore, VE-M drastically increased the centralization of F-actin in human umbilical vein endothelial cells (HUVECs) along the cell contacts, reduced fluorescein isothiocyanate (FITC)-dextran transport across the HUVECs, and elevated expression levels of tight junction proteins (TJPs)...
Source: Biomed Res - April 11, 2019 Category: Research Authors: Yang D, Yan W, Qiu J, Huang Y, Li T, Wang Y, Wang N, Durkan C, Huang J, Yin T, Wang G Tags: J Biomed Mater Res B Appl Biomater Source Type: research

The Effect of Tanreqing Injection on the Pharmacokinetics of Sirolimus in Rats.
Abstract To evaluate the effect of Tanreqing injection on the pharmacokinetics of sirolimus in rats, a high performance liquid chromatography tandem mass spectrometry method was developed for sirolimus assay in whole blood. Calibration curve of sirolimus was acquired over a concentration ranging from 2.5 to 100 ng/mL with r2= 0.9955. The matrix effects and extraction recoveries of sirolimus ranged from 144% to 152% and from 80% to 96%, respectively. The inter- and intraday relative standard deviations were both
Source: Biomed Res - April 10, 2019 Category: Research Authors: Zhang F, Sun L, Zhai J, Xia T, Jiang W, Li M, Gao S, Tao X, Chen W, Chai Y Tags: Biomed Res Int Source Type: research

Centella asiatica Prevents Increase of Hippocampal Tumor Necrosis Factor- α Independently of Its Effect on Brain-Derived Neurotrophic Factor in Rat Model of Chronic Stress.
In conclusion, lower TNF-α and higher BDNF in the hippocampus support the hypothesis that these factors independently contribute to Centella asiatica's neuroprotective effect in chronically stressed rats. PMID: 30956976 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - April 10, 2019 Category: Research Authors: Ar Rochmah M, Harini IM, Septyaningtrias DE, Sari DCR, Susilowati R Tags: Biomed Res Int Source Type: research

Population Pharmacokinetics of Clozapine and Norclozapine and Switchability Assessment between Brands in Uruguayan Patients with Schizophrenia.
tto G Abstract Clozapine (CZP) is an atypical antipsychotic agent commonly used in the treatment of schizophrenia. It is metabolized primarily by CYP1A2 enzyme, yielding a pharmacologically active metabolite, norclozapine (NCZP). Significant intra- and interindividual pharmacokinetic (PK) variability for CZP and NCZP has been observed in routine therapeutic drug monitoring. So the goal of this study was to evaluate the magnitude and variability of concentration exposure to CZP and its active metabolite NCZP on pharmacokinetic parameters in Uruguayan patients with schizophrenia with a focus on covariates such as ci...
Source: Biomed Res - April 10, 2019 Category: Research Authors: Olmos I, Ibarra M, Vázquez M, Maldonado C, Fagiolino P, Giachetto G Tags: Biomed Res Int Source Type: research

SLC9A3 Affects Vas Deferens Development and Associates with Taiwanese Congenital Bilateral Absence of the Vas Deferens.
The objective of the study was to test whether SLC9A3 variants cause Taiwanese CBAVD. Materials and Methods: Six-month-old Slc9a3 -/-male mice were used to evaluate the effect of long-term SLC9A3 loss on the reproductive system. A case-control cohort of 29 men with CBAVD and 32 fertile men were genotyped for SLC9A3 variants. Results: SLC9A3 was expressed and localized in the apical border of the epithelium of human vas deferens and glandular epithelium of the seminal vesicle. SLC9A3 deficiency specifically induces atrophy of vas deferens and unfolding of seminal vesicle mucosa in mice. Loss of SLC9A3 increased th...
Source: Biomed Res - April 10, 2019 Category: Research Authors: Wu YN, Chen KC, Wu CC, Lin YH, Chiang HS Tags: Biomed Res Int Source Type: research

A Rat Model of Radiation Vasculitis for the Study of Mesenchymal Stem Cell-Based Therapy.
Abstract Radiation vasculitis is one of the most common detrimental effects of radiotherapy for malignant tumors. This is developed at the vasculature of adjacent organs. Animal experiments have showed that transplantation of mesenchymal stem cells (MSCs) restores vascular function after irradiation. But the population of MSCs being engrafted into irradiated vessels is too low in the conventional models to make assessment of therapeutic effect difficult. This is presumably because circulating MSCs are dispersed in adjacent tissues being irradiated simultaneously. Based on the assumption, a rat model, namely, RT (r...
Source: Biomed Res - April 10, 2019 Category: Research Authors: Zhang J, Tao X, Sun M, Ying R, Su W, Wei W, Meng X Tags: Biomed Res Int Source Type: research

Microarray Based Functional Analysis of Myricetin and Proteomic Study on Its Anti-Inflammatory Property.
Abstract Myricetin has been reported as a promising chemopreventive compound with multiple biofunctions. To evaluate its influence on gene expressions in genome-wide set and further investigate its anti-inflammatory property, the present study performed Gene Ontology and Ingenuity Pathway Analysis (IPA) to describe the basic gene expression characteristics by myricetin treatment in HepG2 cells, confirmed its multi-biofunction by real-time fluorescent quantitative PCR (RT-qPCR), and further verified its anti-inflammatory property by Western blotting and bio-plex-based cytokines assay. The IPA data showed that 337 g...
Source: Biomed Res - April 10, 2019 Category: Research Authors: Li T, Zhu J, Deng F, Wu W, Zheng Z, Lv C, Li Y, Xiang W, Lu X, Qin S Tags: Biomed Res Int Source Type: research

Wheelchair Tilt-in-Space and Recline Functions: Influence on Sitting Interface Pressure and Ischial Blood Flow in an Elderly Population.
WR Abstract Pressure ulcers (PUs) result from localised injury to the skin and underlying tissue and usually occur over a bony prominence as a result of pressure, often in combination with shear forces. Both pressure magnitude and duration are thought to be key risk factors in the occurrence of PUs, thus exposing wheelchair-bound subjects to high risk of PU development. As a result, wheelchairs that incorporate tilt-in-space and recline functions are routinely prescribed to redistribute pressure away from their ischial tuberosities. The goal of this study was to analyse the role of full-body tilt and recline angl...
Source: Biomed Res - April 10, 2019 Category: Research Authors: Zemp R, Rhiner J, Plüss S, Togni R, Plock JA, Taylor WR Tags: Biomed Res Int Source Type: research

Genetic Modification for Wheat Improvement: From Transgenesis to Genome Editing.
Abstract To feed the growing human population, global wheat yields should increase to approximately 5 tonnes per ha from the current 3.3 tonnes by 2050. To reach this goal, existing breeding practices must be complemented with new techniques built upon recent gains from wheat genome sequencing, and the accumulated knowledge of genetic determinants underlying the agricultural traits responsible for crop yield and quality. In this review we primarily focus on the tools and techniques available for accessing gene functions which lead to clear phenotypes in wheat. We provide a view of the development of wheat transfor...
Source: Biomed Res - April 10, 2019 Category: Research Authors: Borisjuk N, Kishchenko O, Eliby S, Schramm C, Anderson P, Jatayev S, Kurishbayev A, Shavrukov Y Tags: Biomed Res Int Source Type: research

Does Pharmacological Treatment Reduce the Incidence of Lower Urinary Tract Symptoms (LUTS) after Transobturator Sling?
Conclusions: Treatment with solifenacin or mirabegron may significantly reduce the incidence of undesired LUTS after MUS. PMID: 30956983 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - April 10, 2019 Category: Research Authors: Rechberger T, Wrobel A, Zietek A, Rechberger E, Kulik-Rechberger B, Bogusiewicz M, Miotla P Tags: Biomed Res Int Source Type: research

Outcomes of Myomectomy at the Time of Cesarean Section among Pregnant Women with Uterine Fibroids: A Retrospective Cohort Study.
Conclusions: Myomectomy during cesarean section was a common procedure in mainland China. Myomectomy cesarean could be safe and feasible based on the estimation by experienced obstetricians. During the procedure, special attention should be paid to a large-sized leiomyoma ≥5cm and birth weight ≥4,000 g. PMID: 30956984 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - April 10, 2019 Category: Research Authors: Zhao R, Wang X, Zou L, Zhang W Tags: Biomed Res Int Source Type: research