Associations of Serum Nitric Oxide with Vitamin D and Other Metabolic Factors in Apparently Healthy Adolescents.
Abstract Introduction: Nitric oxide (NOx) is an important biomolecule which interacts with other molecules including 25(OH)D to mediate various metabolic pathways. Interactions and associations of NOx with 25(OH)D have been well studied both in vitro and in vivo, yet associations in apparently healthy adolescents have never been studied. Methods: A total of 740 (245 boys and 495 girls) apparently healthy Saudi adolescents aged 10-17 years were included in this cross-sectional study, to determine the associations of NOx with 25(OH)D and other biomarkers in Saudi adolescents. Serum NOx, 25(OH)D, and other bioch...
Source: Biomed Res - December 14, 2018 Category: Research Authors: Al-Daghri NM, Bukhari I, Yakout SM, Sabico S, Khattak MNK, Aziz I, Alokail MS Tags: Biomed Res Int Source Type: research

MicroRNA-9 Enhanced Cisplatin Sensitivity in Nonsmall Cell Lung Cancer Cells by Regulating Eukaryotic Translation Initiation Factor 5A2.
Abstract We determined the role of microRNA (miR)-9 in regulating cisplatin chemoresistance in nonsmall cell lung cancer (NSCLC) cells. miR-9 and eukaryotic translation initiation factor 5A2 (eIF5A2) levels were examined by reverse transcription-quantitative PCR. Cell Counting Kit-8 and the 5-ethynyl-2'-deoxyuridine (EdU) assay were used to determine the effects of miR-9 mimic or inhibitor on NSCLC cell proliferation and viability, respectively. Bioinformatics was used to analyze the relationship between miR-9 and eIF5A2. Flow cytometry was used to analyze the percentage of apoptotic cells. miR-9 mimic enhanced ci...
Source: Biomed Res - December 14, 2018 Category: Research Authors: Pan Q, Sun L, Zheng D, Li N, Shi H, Song J, Shao G, Xu G Tags: Biomed Res Int Source Type: research

Comparative Study of the Fit Accuracy of Full-Arch Bar Frameworks Fabricated with Different Presintered Cobalt-Chromium Alloys.
This study was to measure the geometric discrepancies that occur during the sintering contraction of presintered Co-Cr alloys in a full-arch bar framework and to compare the variations between alloys from different manufacturers. Materials and Methods: Eighteen implant-supported full-arch bar frameworks were fabricated through a soft-machining process using presintered Co-Cr alloy blocks: Ceramill Sintron (CS), Soft Metal (SM), and Sintermetall (SML) (n=6 for each group). The sintered frameworks were digitized using a structured light scanner, and the scan images were superimposed on the reference design. The geometri...
Source: Biomed Res - December 14, 2018 Category: Research Authors: Mai HN, Kwon TY, Hong MH, Lee DH Tags: Biomed Res Int Source Type: research

Insecticide Resistance Associated with kdr Mutations in Aedes albopictus: An Update on Worldwide Evidences.
Abstract Insecticide resistance is an increasing problem worldwide that limits the efficacy of control methods against several pests of health interest. Among them, Aedes albopictus mosquitoes are efficient vectors of relevant pathogens causing animal and human diseases worldwide, including yellow fever, chikungunya, dengue, and Zika. Different mechanisms are associated in conferring resistance to chemical insecticides. One of the most widespread and analysed mechanisms is the knockdown resistance (kdr) causing resistance to DDT and pyrethroids. The mechanism is associated with mutations in the voltage sensitive s...
Source: Biomed Res - December 14, 2018 Category: Research Authors: Auteri M, La Russa F, Blanda V, Torina A Tags: Biomed Res Int Source Type: research

Mutation Study of Malaysian Patients with Ornithine Transcarbamylase Deficiency: Clinical, Molecular, and Bioinformatics Analyses of Two Novel Missense Mutations of the OTC Gene.
In this study, we report two novel OTC missense mutations, Q171H and N199H, found in Malaysian patients. Q171H and N199H caused neonatal onset OTCD in a male and late OTCD in a female, respectively. In silico predictions and molecular docking were performed to examine the effect of these novel mutations, and the results were compared with other 30 known OTC mutations. In silico servers predicted that Q171H and N199H, as well as 30 known missense mutations, led to the development of OTCD. Docking analysis indicated that N-(phosphonoacetyl)-L-ornithine (PALO) was bound to the catalytic site of OTCase mutant structure with mi...
Source: Biomed Res - December 14, 2018 Category: Research Authors: Ali EZ, Zakaria Y, Mohd Radzi MA, Ngu LH, Jusoh SA Tags: Biomed Res Int Source Type: research

Diagnostic and Vaccination Approaches for Newcastle Disease Virus in Poultry: The Current and Emerging Perspectives.
Abstract Newcastle disease (ND) is one of the most devastating diseases that considerably cripple the global poultry industry. Because of its enormous socioeconomic importance and potential to rapidly spread to naïve birds in the vicinity, ND is included among the list of avian diseases that must be notified to the OIE immediately upon recognition. Currently, virus isolation followed by its serological or molecular identification is regarded as the gold standard method of ND diagnosis. However, this method is generally slow and requires specialised laboratory with biosafety containment facilities, making it o...
Source: Biomed Res - December 14, 2018 Category: Research Authors: Bello MB, Yusoff K, Ideris A, Hair-Bejo M, Peeters BPH, Omar AR Tags: Biomed Res Int Source Type: research

Plants and Their Bioactive Constituents in Mesenchymal Stem Cell-Based Periodontal Regeneration: A Novel Prospective.
Abstract Periodontitis is a common chronic inflammatory disease, which causes the destruction of both the soft and mineralized tissues. However, current treatments such as bone graft materials, barrier membranes, and protein products all have difficulties in regenerating the complete periodontal tissue structure. Stem cell-based tissue engineering has now emerged as one of the most effective treatments for the patients suffering from periodontal diseases. Plants not only can be substrates for life processes, but also contain hormones or functional molecules. Numbers of preclinical studies have revealed that produc...
Source: Biomed Res - December 14, 2018 Category: Research Authors: Xue W, Yu J, Chen W Tags: Biomed Res Int Source Type: research

Heart Rate and Perceived Experience Differ Markedly for Children in Same- versus Mixed-Gender Soccer Played as Small- and Large-Sided Games.
This study examines heart rate (HR) and perceived experience during same- versus mixed-gender soccer played as small- (SSG) and large-sided (LSG) games. HR, rating of perceived exertion (RPE), and fun scores were determined in 134 pupils (50 girls, 84 boys) randomly assigned to same- and mixed-genders formats playing 2x15-min of SSG (2v2, 4v4) and LSG (12v12) in a random order (~50 m2/player). HR was lower (p≤0.03) for girls when playing together with boys than when playing alone (71±10 versus 77±7%HRmax), while being similar for boys playing mixed- or same-gender games (74±7 versus 77±4%HRma...
Source: Biomed Res - December 14, 2018 Category: Research Authors: Póvoas S, Randers MB, Krustrup P, Larsen MN, Pereira R, Castagna C Tags: Biomed Res Int Source Type: research

Study on Biological Characteristics and Mechanism of Paclitaxel Induced Drug Resistance in Endometrial Carcinoma Cells.
Conclusion: Paclitaxel can inhibit Ishikawa and Ishikawa-TAX cell via PI3K/Akt/mTOR signaling pathway. Paclitaxel and NVP-BEZ235 cotreatment can enhance the inhibitory effect. PMID: 30175145 [PubMed - indexed for MEDLINE] (Source: Biomed Res)
Source: Biomed Res - December 14, 2018 Category: Research Authors: Ding J, Li M, Deng L, Li T Tags: Biomed Res Int Source Type: research

Ghrelin Ameliorates Angiotensin II-Induced Myocardial Fibrosis by Upregulating Peroxisome Proliferator-Activated Receptor Gamma in Young Male Rats.
Abstract Angiotensin (Ang) II contributes to the formation and development of myocardial fibrosis. Ghrelin, a gut peptide, has demonstrated beneficial effects against cardiovascular disease. In the present study, we explored the effect and related mechanism of Ghrelin on myocardial fibrosis in Ang II-infused rats. Adult Sprague-Dawley (SD) rats were divided into 6 groups: Control, Ang II (200ng/kg/min, microinfusion), Ang II+Ghrelin (100 μg/kg, subcutaneously twice daily), Ang II+Ghrelin+GW9662 (a specific PPAR-γ inhibitor, 1 mg/kg/d, orally), Ang II+GW9662, and Ghrelin for 4 wks. In vitro, adult rat card...
Source: Biomed Res - December 14, 2018 Category: Research Authors: Wang Q, Sui X, Chen R, Ma PY, Teng YL, Ding T, Sui DJ, Yang P Tags: Biomed Res Int Source Type: research

Heteroplasmy Detection of Mitochondrial DNA A3243G Mutation Using Quantitative Real-Time PCR Assay Based on TaqMan-MGB Probes.
Abstract A point mutation of mitochondrial DNA (mtDNA) at nucleotide position 3243 A to G (mt.3243A>G) is involved in many common diseases, including maternally inherited diabetes and deafness (MIDD) and mitochondrial encephalomyopathy, lactic acidosis with stroke-like episodes (MELAS). However, the mutant level of mt.3243A>G varies both among individuals and in different organs, tissues, and even cells of single individuals. For detection of this mutation, current methods have limited universality and sensitivity and may be not adequate for a routine clinical test. Here, we develop and evaluate a rapid TaqM...
Source: Biomed Res - December 14, 2018 Category: Research Authors: Rong E, Wang H, Hao S, Fu Y, Ma Y, Wang T Tags: Biomed Res Int Source Type: research

Selective Progesterone Receptor Modulators for the Medical Treatment of Uterine Fibroids with a Focus on Ulipristal Acetate.
Abstract Uterine fibroids are the most frequent benign tumours in women of child-bearing age. Their symptoms are diverse and the quality of life of the women affected can be significantly impaired. While treatment to date has been primarily by means of surgical intervention, selective progesterone receptor modulators (SPRMs) open up new medication-based treatment options. EMA's Pharmacovigilance Risk Assessment Committee (PRAC) has recently completed its review of ESMYA® (ulipristal acetate, 5 mg), following reports of serious liver injury, including liver failure leading to transplantation in postmarketing se...
Source: Biomed Res - December 14, 2018 Category: Research Authors: Rabe T, Saenger N, Ebert AD, Roemer T, Tinneberg HR, De Wilde RL, Wallwiener M Tags: Biomed Res Int Source Type: research

A Novel MLH1 Initiation Codon Mutation (c.3G > T) in a Large Chinese Lynch Syndrome Family with Different Onset Age and mRNA Expression Level.
A Novel MLH1 Initiation Codon Mutation (c.3G>T) in a Large Chinese Lynch Syndrome Family with Different Onset Age and mRNA Expression Level. Biomed Res Int. 2018;2018:1460835 Authors: Zhang Y, Chen H, Peng Z, Banerjee S, Li W, Zhao Z, Sun J, Lv J, Huang H, Bai R, Lin K, Li Z Abstract Lynch syndrome is a genetically and clinically heterogeneous disorder; it is caused by a germline mutation in DNA mismatch repair (MMR) genes. Individuals with a heterozygous mutation in MLH1 have an increased risk for developing colorectal cancer. Here we described a 5-generation Chinese Lynch syndrome family with dif...
Source: Biomed Res - December 14, 2018 Category: Research Authors: Zhang Y, Chen H, Peng Z, Banerjee S, Li W, Zhao Z, Sun J, Lv J, Huang H, Bai R, Lin K, Li Z Tags: Biomed Res Int Source Type: research

Functional Probiotic Assessment and In Vivo Cholesterol-Lowering Efficacy of Weissella sp. Associated with Arid Lands Living-Hosts.
This study aimed to evaluate the functional properties of Weissella strains from arid land living-hosts and to select strains with cholesterol-lowering property in vitro and in vivo, for use as probiotics. They were assessed for acid and bile tolerance, antibiotic susceptibility, membrane properties, antibacterial activity, antiadhesive effect against pathogens to host cell lines, and cholesterol assimilation in vitro. Our results showed that the majority of strains revealed resistance to gastrointestinal conditions. All the strains were nonhemolytic and sensitive to most of the tested antibiotics. They also exhibited high...
Source: Biomed Res - December 14, 2018 Category: Research Authors: Fhoula I, Rehaiem A, Najjari A, Usai D, Boudabous A, Sechi LA, Hadda-Imene O Tags: Biomed Res Int Source Type: research

Increased Autophagy Levels Mediate Cisplatin Resistance in Cisplatin-Resistant Cells While Also Rendering Them Vulnerable to Autophagy Induction.
Abstract Autophagy plays an important role in tumor development because of its capacity to maintain energy homeostasis by recycling damaged intracellular proteins and organelles, and increased autophagy levels are reported to mediate drug resistance in many cancers. However, whether high autophagy levels negatively impact tumor cell growth is unknown. Herein, we found that cisplatin (ddp)-resistant cells were more sensitive to glutamine (Gln) deprivation than ddp-sensitive cells, and they showed significant G1 arrest and increased apoptosis rates under Gln-deficient conditions. Furthermore, ddp-resistant cells had...
Source: Biomed Res - December 14, 2018 Category: Research Authors: Duan G, Song Z, Qi M, Bai X, Wang J, Zhang Y, Zou X, Guo Q, Wan P Tags: Biomed Res Int Source Type: research

Reference Intervals of Thyroid Hormones and Correlation of BMI with Thyroid Function in Healthy Zhuang Ethnic Pregnant Women.
This study was performed to establish trimester-specific reference ranges of thyroid hormones in Zhuang ethnic pregnant women and explore the role of body mass index (BMI) on thyroid function. A total of 3324 Zhuang ethnic health pregnant women were recruited in this Zhuang population-based retrospective cross-sectional study. The values of thyroid stimulating hormone (TSH), free thyroxine (FT4), and free triiodothyronine (FT3) were determined by automatic chemiluminescence immunoassay analyzer. Multivariate linear regression and binary logistic regression were constructed to evaluate the influence of BMI on the thyroid fu...
Source: Biomed Res - December 14, 2018 Category: Research Authors: Sheng Y, Huang D, Liu S, Guo X, Chen J, Shao Y, Zhang G, Wei L, Zeng X, Qiu X Tags: Biomed Res Int Source Type: research

Acetylation of HMGB1 by JNK1 Signaling Promotes LPS-Induced Peritoneal Mesothelial Cells Apoptosis.
In conclusion, our data demonstrated HMGB1 promotes LPS-induced peritoneal mesothelial cells apoptosis, which is associated with JNK1-mediated upregulation of HMGB1 acetylation. PMID: 30539006 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - December 14, 2018 Category: Research Authors: Cao S, Li S, Wang Y, Shen J, Zhou Y, Li H, Yu X, Mao H Tags: Biomed Res Int Source Type: research

Pelargonium graveolens Aqueous Decoction: A New Water-Soluble Polysaccharide and Antioxidant-Rich Extract.
Conclusion: The obtained results suggest that the CPGP rheological characteristics are suitable for applications in many industries, especially food. The values of optimal conditions showed that Pelargonium graveolens decoction operation could have multiple uses, especially for consuming less energy. PMID: 30539007 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - December 14, 2018 Category: Research Authors: Ennaifer M, Bouzaiene T, Chouaibi M, Hamdi M Tags: Biomed Res Int Source Type: research

Antimicrobial Fatty Acids from Green Alga Ulva rigida (Chlorophyta).
This study deals with the antimicrobial potential assessment of Ulva rigida, in regard to collection period and sampling site. Besides, we assess the chemical composition of bioactive compounds. For this purpose, Ulva rigida was seasonally collected from two northern sites in Tunisia, Cap Zebib rocky shore (CZ) and Ghar El Melh lagoon (GEM). Crude organic extracts were prepared using dichloromethane and dichloromethane/methanol and tested against 19 indicator microorganisms using the disk diffusion method and microdilution technique to determine the minimum inhibitory concentration (MIC). Silica gel column and thin layer c...
Source: Biomed Res - December 14, 2018 Category: Research Authors: Ismail A, Ktari L, Ben Redjem Romdhane Y, Aoun B, Sadok S, Boudabous A, El Bour M Tags: Biomed Res Int Source Type: research

Artificial Neural Network to Predict Varicocele Impact on Male Fertility through Testicular Endocannabinoid Gene Expression Profiles.
oni B Abstract The relationship between varicocele and fertility has always been a matter of debate because of the absence of predictive clinical indicators or molecular markers able to define the severity of this disease. Even though accumulated evidence demonstrated that the endocannabinoid system (ECS) plays a central role in male reproductive biology, particularly in the testicular compartment, to date no data point to a role for ECS in the etiopathogenesis of varicocele. Therefore, the present research has been designed to investigate the relationship between testicular ECS gene expression and fertility, usin...
Source: Biomed Res - December 14, 2018 Category: Research Authors: Perruzza D, Bernabò N, Rapino C, Valbonetti L, Falanga I, Russo V, Mauro A, Berardinelli P, Stuppia L, Maccarrone M, Barboni B Tags: Biomed Res Int Source Type: research

Yes-Associated Protein 1 as a Novel Prognostic Biomarker for Gastrointestinal Cancer: A Meta-Analysis.
Abstract Background: Yes-associated protein 1 (YAP1) is an effector of Hippo pathway, which plays a significant role in cell proliferation and tumor progression. The relationship between YAP1 and gastrointestinal cancer has been explored in many previous studies. We conducted a meta-analysis to explore the prognostic effect of YAP1 in patients with gastrointestinal cancer. Methods: A systematic search was performed through the PubMed, Web of Science, Embase, and Cochrane library databases to collect eligible studies. The pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were used to evaluate the ...
Source: Biomed Res - December 14, 2018 Category: Research Authors: Zhang L, Song X, Li X, Wu C, Jiang J Tags: Biomed Res Int Source Type: research

Circulating MicroRNA-4739 May Be a Potential Biomarker of Critical Limb Ischemia in Patients with Diabetes.
In this study, microarray profiling revealed 11 miRNAs with significantly altered expression in four T2DM patients with CLI compared with that in four sex- and age-matched T2DM patients without CLI. In independent cohorts, qRT-PCR validation confirmed the increased miRNA-4739 level in patients with CLI versus patients without CLI. miRNA-4739 levels increased with FPG and HbA1c (all P
Source: Biomed Res - December 14, 2018 Category: Research Authors: Li JY, Cheng B, Wang XF, Wang ZJ, Zhang HM, Liu SF, Chen LS, Huang WJ, Liu J, Deng AP Tags: Biomed Res Int Source Type: research

Use of Artificial Neural Network in Determination of Shade, Light Curing Unit, and Composite Parameters' Effect on Bottom/Top Vickers Hardness Ratio of Composites.
i A Abstract Objective: To assess the influence of light emitting diode (LED) and quartz tungsten halogen (QTH) light curing unit (LCU) on the bottom/top (B/T) Vickers Hardness Number (VHN) ratio of different composites with different shades and determination of the most significant effect on B/T VHN ratio of composites by shade, light curing unit, and composite parameters using artificial neural network. Method: Three composite resin materials [Clearfil Majesty Esthetic (CME), Tetric N Ceram (TNC), and Tetric Evo Ceram (TEC)] in different shades (HO, A2, B2, Bleach L, Bleach M) were used. The composites were...
Source: Biomed Res - December 14, 2018 Category: Research Authors: Deniz Arısu H, Eligüzeloglu Dalkilic E, Alkan F, Erol S, Uctasli MB, Cebi A Tags: Biomed Res Int Source Type: research

Impact of an In-House Pediatric Surgery Unit and Human Milk Centered Enteral Nutrition on Necrotizing Enterocolitis.
Abstract The importance for mortality and morbidity of an in-house pediatric surgery unit for premature infants with necrotizing enterocolitis (NEC) remains undefined. Data on 389 consecutive very low birth weight infants with a birth weight
Source: Biomed Res - December 14, 2018 Category: Research Authors: Zamrik S, Giachero F, Heldmann M, Hensel KO, Wirth S, Jenke AC Tags: Biomed Res Int Source Type: research

Cytokine Effect of TLR3, TLR4, and TLR7 Agonists Alone or Associated with Leishmania infantum Antigen on Blood from Dogs.
Solano-Gallego L Abstract Activation of toll-like receptors (TLRs) has been shown to play an important role in leishmaniosis by enhancing the parasite specific immune responses to control infection. However, the role of TLR agonists has not been studied in detail in dogs. The aim of this study was to determine the effect of TLR3, TLR4, and TLR7 agonists (TLR3a, TLR4a, and TLR7a) alone or in combination with Leishmania infantum antigen (LSA) on TNF-α and IL-6 production in blood from dogs living in endemic areas of canine leishmaniosis (CanL). Twenty-four healthy dogs from Catalonia (n=14) and Ibizan hound d...
Source: Biomed Res - December 14, 2018 Category: Research Authors: Martínez-Orellana P, Montserrat-Sangrà S, Quirola-Amores P, González N, Solano-Gallego L Tags: Biomed Res Int Source Type: research

Exploring Epidemiological Aspects, Distribution of WHO Maternal Near Miss Criteria, and Organ Dysfunction Defined by SOFA in Cases of Severe Maternal Outcome Admitted to Obstetric ICU: A Cross-Sectional Study.
Conclusions: The systematic evaluation of the organic function by SOFA max score identified the presence of organic dysfunction or failure in almost all SMO cases. Management criteria were present in all MD cases. Our results indicate the need for new studies evaluating the parameterization of the WHO laboratory criteria for values compatible with the definition of organic dysfunction by the SOFA to identify MNM. PMID: 30539015 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - December 14, 2018 Category: Research Authors: Oliveira Neto AF, Parpinelli MA, Costa ML, Souza RT, Ribeiro do Valle C, Cecatti JG Tags: Biomed Res Int Source Type: research

Reconstruction of Severe Acetabular Bone Defect with 3D Printed Ti6Al4V Augment: A Finite Element Study.
Conclusions: The FEA results show that all the components will be intact under single-legged standing. However, partial cancellous bone contacted with 3D printed augment and screws will lose efficacy under walking or jogging load. So we recommend that patients can stand under full bearing, but can not walk or jog immediately after surgery. PMID: 30539016 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - December 14, 2018 Category: Research Authors: Fu J, Ni M, Chen J, Li X, Chai W, Hao L, Zhang G, Zhou Y Tags: Biomed Res Int Source Type: research

Innovative Techniques to Enhance Musculoskeletal Surgery Outcomes.
PMID: 30539017 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - December 14, 2018 Category: Research Authors: Di Matteo B, Angele P, Lattermann C, Kon E Tags: Biomed Res Int Source Type: research

Mitochondrial DNA D-Loop Diversity of the Helmeted Guinea Fowls in Kenya and Its Implications on HSP70 Gene Functional Polymorphism.
Abstract We analyzed variations in 90 mitochondrial DNA (mtDNA) D-loop and heat shock protein 70 (HSP70) gene sequences from four populations of domesticated helmeted Guinea fowls (70 individuals) and 1 population of wild helmeted Guinea fowls (20 individuals) in Kenya in order to get information about their origin, genetic diversity, and traits associated with heat stress. 90 sequences were assigned to 25 distinct mtDNA and 4 HSP70 haplotypes. Most mtDNA haplotypes of the domesticated helmeted Guinea fowls were grouped into two main haplogroups, HgA and HgB. The wild population grouped into distinct mtDNA haplogr...
Source: Biomed Res - December 14, 2018 Category: Research Authors: Murunga P, Kennedy GM, Imboma T, Malaki P, Kariuki D, Ndiema E, Obanda V, Agwanda B, Lichoti JK, Ommeh SC Tags: Biomed Res Int Source Type: research

Prognostic Significance of Platelet-to-Lymphocyte Ratio in Cholangiocarcinoma: A Meta-Analysis.
This study aimed to evaluate the prognostic value of pretreatment PLR in cholangiocarcinoma. Methods: A systematic search was performed in MEDLINE, EMBASE, and Cochrane Library to identify studies assessing the prognostic significance of the pretreatment PLR in cholangiocarcinoma. Three databases were searched from inception to August 5, 2018. The primary outcome was overall survival (OS), and the secondary outcomes were recurrence-free survival (RFS) and progression-free survival (PFS). Pooled hazard ratios (HRs) or odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using random-effects models. ...
Source: Biomed Res - December 14, 2018 Category: Research Authors: Hu G, Liu Q, Ma JY, Liu CY Tags: Biomed Res Int Source Type: research

The Effect of Modified Biolasol Solution on the Efficacy of Storing Isolated Porcine Kidneys.
zka F Abstract Biolasol is a newly developed solution for storing the liver, pancreas, kidneys, and heart by simple hypothermia. It exhibits high efficacy in maintaining structural and functional integrity of the graft prior to its transplantation. The solution was modified by the addition of ascorbic acid (0.088g/l) and ascorbic acid with prolactin (1 μg/l PRL + 0.088g/l vitamin C). The effectiveness of the obtained solutions in the protection of nephrons of isolated porcine kidneys was assessed based on the analysis of the activity of ALT (alanine aminotransferase), AST (aspartate aminotransferase), an...
Source: Biomed Res - December 14, 2018 Category: Research Authors: Ostróżka-Cieślik A, Dolińska B, Ryszka F Tags: Biomed Res Int Source Type: research

Encapsulating Peritoneal Sclerosis in Long-Termed Peritoneal Dialysis Patients.
Abstract Background: Encapsulating peritoneal sclerosis (EPS) is a rare but serious clinical complication of long-term peritoneal dialysis (PD) patients with high mortality. The purpose of this study was to assess the clinical characteristics of patients with EPS and to search for possible factors useful for EPS prevention and early diagnosis. Method: This retrospective study was performed in a single dialysis center in Taiwan between August 1990 and April 2014. Overall, a total of 565 patients were included and the medical records of those patients who had developed EPS (EPS group) and those who had not deve...
Source: Biomed Res - December 14, 2018 Category: Research Authors: Hsu HJ, Yang SY, Wu IW, Hsu KH, Sun CY, Chen CY, Lee CC Tags: Biomed Res Int Source Type: research

Effect of Quercetin Monoglycosides on Oxidative Stress and Gut Microbiota Diversity in Mice with Dextran Sodium Sulphate-Induced Colitis.
In conclusion, this research showed that even at a low dose, dietary Q or Q+MQ supplementation counteracts DSS-induced colitis in mice, indicating that Q or Q+MQ may be used as an adjuvant therapy for IBD patients. PMID: 30539022 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - December 14, 2018 Category: Research Authors: Hong Z, Piao M Tags: Biomed Res Int Source Type: research

Oxidation-Reduction Potential in Patients undergoing Transcatheter or Surgical Aortic Valve Replacement.
e G Abstract Background: Aortic valve stenosis has gained increasingly more importance due to its high prevalence in elderly people. More than two decades ago, transcatheter aortic valve replacement emerged for patients who were denied surgery, and its noninferiority has been demonstrated in numerous studies. Oxidative stress has generated great interest because of its sensitivity to cell damage and the possibility of offering early hints of clinical outcomes. The aim of the present study was to investigate whether there is a significant difference between transcatheter (TAVR) or surgical aortic valve replacement ...
Source: Biomed Res - December 14, 2018 Category: Research Authors: Heldmaier K, Stoppe C, Goetzenich A, Foldenauer AC, Zayat R, Breuer T, Schälte G Tags: Biomed Res Int Source Type: research

The Effect of Chlorhexidine and Listerine ® Mouthwashes on the Tensile Strength of Selected Absorbable Sutures: An In Vitro Study.
Conclusion: Oral surgeons and periodontists should be cautious when prescribing commercial mouthwashes for patients relative to their selection of suture materials. However, further studies are needed to understand the molecular changes in sutures when exposed to chemical solutions found in mouthwashes. PMID: 30539024 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - December 14, 2018 Category: Research Authors: Alsarhan M, Alnofaie H, Ateeq R, Almahdy A Tags: Biomed Res Int Source Type: research

Relationship of Red Blood Cell Distribution Width with Cancer Mortality in Hospital.
Conclusion: Elevated RDW was associated with overall cancer mortality. To a certain extent, RDW may predict the risk of mortality in patients with cancers; it was an independent prognostic indicator of short-term mortality after hospitalization in cancer patients. PMID: 30539025 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - December 14, 2018 Category: Research Authors: Li J, Yang X, Ma J, Gong F, Chen Q Tags: Biomed Res Int Source Type: research

Biomed Res; +138 new citations
138 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Biomed Res These pubmed results were generated on 2018/12/12PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: Biomed Res)
Source: Biomed Res - December 13, 2018 Category: Research Tags: Report Source Type: research

New COPE guidelines on publication process manipulation: why they matter.
Abstract Manipulation of the publication process is a relatively new form of misconduct affecting the publishing industry. This editorial describes what it is, why it is difficult for individual journal editors and publishers to handle and the background to the development of the new COPE guidelines on how to manage publication process manipulation. These new guidelines represent an important first step towards encouraging openness and collaboration between publishers to address this phenomenon. PMID: 30505466 [PubMed] (Source: Biomed Res)
Source: Biomed Res - December 8, 2018 Category: Research Authors: Patel J Tags: Res Integr Peer Rev Source Type: research

Youth Violence and Related Risk Factors: A Cross-sectional Study in 2800 Adolescents.
Abstract Background: Youth violence is an important public health challenge, and the literature on this problem in developing countries has been limited. The present study aims to determine the prevalence of violence its related risk factors in in a sample of students in Isfahan, Iran. Materials and Methods: In this cross-sectional study, 2800 middle and high school, aged 11-18 years in urban and rural areas selected in a multistage sampling procedure and were questioned using a self-administered questionnaire. Collected data included sociodemographic and family characteristics, students' knowledge, verbal an...
Source: Biomed Res - December 8, 2018 Category: Research Authors: Golshiri P, Farajzadegan Z, Tavakoli A, Heidari K Tags: Adv Biomed Res Source Type: research

Impact of Health Information Prescription on Self-care of Women with Breast Cancer.
Abstract Background: Women with breast cancer experience various challenges. Prescription of health information provides appropriate information at appropriate time to the appropriate person and plays a role in empowering self-care and improving health. The current research aims to evaluate the effect of health information prescription on self-care power of women with breast cancer. Materials and Methods: This semi-experimental quantitative study was done using pretest and posttest method in one group of 61 women with breast cancer selected from the Women's Cancer Center of Khatamolanbia Hospital using purpos...
Source: Biomed Res - December 8, 2018 Category: Research Authors: Latifi M, Alishan Karami N, Beiraghdar M, Maraki F, Allahbakhshian Farsani L Tags: Adv Biomed Res Source Type: research

Comparison the Effects of Oral Tizanidine and Tramadol on Intra- and Post-operative Shivering in Patients Underwent Spinal Anesthesia.
Conclusions: Oral TI and tramadol were comparable in respect to their effect in decreasing the incidence, intensity shivering when used prophylactically in patients who underwent TURP with spinal anesthesia. PMID: 30505811 [PubMed] (Source: Biomed Res)
Source: Biomed Res - December 8, 2018 Category: Research Authors: Adinehmehr L, Salimi S, Majedi MA, Alizadeh A, Sane S Tags: Adv Biomed Res Source Type: research

Applying Two Different Bioinformatic Approaches to Discover Novel Genes Associated with Hereditary Hearing Loss via Whole-Exome Sequencing: ENDEAVOUR and HomozygosityMapper.
Conclusion: WES is regarded a powerful approach to discover molecular etiology of Mendelian inherited disorders, but as it fails to enrich GC-rich regions, incapability of capturing noncoding regulatory regions and limited specificity and accuracy of copy number variations detection tools from exome data, it is assumed an insufficient procedure. PMID: 30505812 [PubMed] (Source: Biomed Res)
Source: Biomed Res - December 8, 2018 Category: Research Authors: Pourreza MR, Mohammadi H, Sadeghian L, Asgharzadeh S, Sehhati M, Tabatabaiefar MA Tags: Adv Biomed Res Source Type: research

Evaluating the Longitudinal Item and Category Stability of the SF-36 Full and Summary Scales Using Rasch Analysis.
Conclusion: Previous evaluations of the SF-36 have relied on cross-sectional data; however, the findings of the current study demonstrate the longitudinal efficacy of the measure. Application of the Rasch Measurement Model indicated issues with internal consistency, generalisability, and sensitivity when the measure was evaluated as a whole and as both physical and mental health summary scales. Implications for future research are discussed. PMID: 30519566 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - December 8, 2018 Category: Research Authors: Cordier R, Brown T, Clemson L, Byles J Tags: Biomed Res Int Source Type: research

Effect of Comorbidity on Lung Cancer Diagnosis Timing and Mortality: A Nationwide Population-Based Cohort Study in Taiwan.
This study collected various comorbidity patients and analyzed data regarding the lung cancer diagnosis and survival during a 16-year follow-up period (1995-2010). In total, 101,776 lung cancer patients were included, comprising 44,770 with and 57,006 without comorbidity. The Kaplan-Meier analyses were used to compare overall survival between lung cancer patients with and without comorbidity. In our cohort, chronic bronchitis patients who developed lung cancer had the lowest overall survival in one (45%), five (28.6%), and ten years (26.2%) since lung cancer diagnosis. Among lung cancer patients with nonpulmonary comorbidi...
Source: Biomed Res - December 8, 2018 Category: Research Authors: Dima S, Chen KH, Wang KJ, Wang KM, Teng NC Tags: Biomed Res Int Source Type: research

Endophytic Actinomycetes from Tea Plants (Camellia sinensis): Isolation, Abundance, Antimicrobial, and Plant-Growth-Promoting Activities.
In this study, a total of 46 actinobacteria were recovered from leaf, stem, and root samples of 15 tea cultivars collected in Fujian province, China. Their abundance and diversity were shown to be influenced by both the genotypes and tissue types of tea plants. Based on 16S RNA sequence analysis, these isolates were taxonomically grouped into 11 families and 13 genera, including Streptomyces, Actinomadura, Kribbella, Nocardia, Kytococcus, Leifsonia, Microbacterium, Micromonospora, Mobilicoccus, Mycobacterium, Nocardiopsis, Piscicoccus, and Pseudonocardia. The genus Streptomyces was most prevalent whereas rare genera, Mobil...
Source: Biomed Res - December 8, 2018 Category: Research Authors: Shan W, Zhou Y, Liu H, Yu X Tags: Biomed Res Int Source Type: research

Should We Always Use Antibiotics after Urodynamic Studies in High-Risk Patients?
Abstract Aim: The aim of this observational study was to evaluate the effectiveness of a phytotherapic drug (Canephron N) in preventing urinary tract infection (UTI) in high-risk women undergoing urodynamic studies (UDS). Methods: The study protocol was approved by the local institutional ethical committee. Adult women with at least one risk factor for acquiring UTI (defined as: age over 70, elevated postvoid residual urine>100 ml, recurrent UTI, pelvic organ prolapse (POP) ≥II in POP-Q scale, and neurogenic bladder) had received after UDS either a single oral dose of fosfomycin trometamol (FT) (...
Source: Biomed Res - December 8, 2018 Category: Research Authors: Miotla P, Wawrysiuk S, Naber K, Markut-Miotla E, Skorupski P, Skorupska K, Rechberger T Tags: Biomed Res Int Source Type: research

Cyclic Stretch Enhances Osteogenic Differentiation of Human Periodontal Ligament Cells via YAP Activation.
Abstract Periodontal remodeling and alveolar bone resorption and formation play essential roles during orthodontic tooth movement (OTM). In the process, human periodontal ligament cells (HPDLCs) sense and respond to orthodontic forces, contributing to the alveolar bone formation. However, the underlying mechanism in this process is not fully elucidated. In the present study, cyclic stress stimulus was applied on HPDLCs to mimic the orthodontic forces during OTM. Our results demonstrated that cyclic stretch promoted the osteogenic differentiation of HPDLCs. Moreover, our data suggested that yes-associated protein (...
Source: Biomed Res - December 8, 2018 Category: Research Authors: Yang Y, Wang BK, Chang ML, Wan ZQ, Han GL Tags: Biomed Res Int Source Type: research

A Comparative Study of Smartphone Game with Spirometry for Pulmonary Function Assessment in Stroke Patients.
Conclusion: We compared the relationship between the SGA and the spirometry as certified pulmonary function test. The SGA data were statistically significant and reliable for pulmonary function assessment in stroke patients. It will therefore be useful during rehabilitation to improve pulmonary function and clinical monitoring in stroke patients. PMID: 30519571 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - December 8, 2018 Category: Research Authors: Joo S, Lee K, Song C Tags: Biomed Res Int Source Type: research

Antagonism of Bacteria from Dog Dental Plaque against Human Cariogenic Bacteria.
This study used 95 bacterial isolates of canine dental plaque from the Veterinary Department at the Federal University of Viçosa, Minas Gerais, Brazil. A spot-on-the-lawn method was performed using Brain Heart Infusion agar with catalase for an initial identification of the antagonistic activity. Additional tests were conducted on the isolates classified as antagonists for confirmation of the activity, using modified Mann-Rogosa-Sharpe medium containing low dextrose concentration. These isolates were incubated at 37°C for 24 hours in anaerobiosis. The peptide nature of inhibition was evaluated using the followin...
Source: Biomed Res - December 8, 2018 Category: Research Authors: Martins KS, Magalhães LTA, de Almeida JG, Pieri FA Tags: Biomed Res Int Source Type: research

A Simple Guideline to Assess the Characteristics of RNA-Seq Data.
In this study, we provide a simple method that can intuitively evaluate RNA-seq data using two different principal component analysis (PCA) plots. The gene expression PCA plot provides insights into the association between samples, while the transcript integrity number (TIN) score plot provides a quality map of given RNA-seq data. With this approach, we found that RNA-seq datasets deposited in public repositories often contain a few low-quality RNA-seq data that can lead to misinterpretations. The effect of sampling errors for differentially expressed gene (DEG) analysis was evaluated with ten RNA-seq data from invasive du...
Source: Biomed Res - December 8, 2018 Category: Research Authors: Son K, Yu S, Shin W, Han K, Kang K Tags: Biomed Res Int Source Type: research