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Effects of intramedullary nails composed of a new β-type Ti-Nb-Sn alloy with low Young's modulus on fracture healing in mouse tibiae.
This study aimed to assess the effects of intramedullary nails composed of materials with low Young's moduli on fracture repair. We previously developed a β-type Ti-Nb-Sn alloy with low Young's modulus close to that of human cortical bone. Here, we prepared two Ti-Nb-Sn alloys with Young's moduli of 45 and 78 GPa by heat treatment, and compared their effects on fracture healing. Fracture and nailing were performed in the right tibiae of C57BL/6 mice. The bone healing process was evaluated by microcomputed tomography (micro-CT), histomorphometry, and RT-PCR. We found larger bone volumes of fracture callus in the mice t...
Source: Biomed Res - January 23, 2018 Category: Research Authors: Fujisawa H, Mori Y, Kogure A, Tanaka H, Kamimura M, Masahashi N, Hanada S, Itoi E Tags: J Biomed Mater Res B Appl Biomater Source Type: research

Fabrication of functionalized citrus pectin/silk fibroin scaffolds for skin tissue engineering.
In this study, novel porous three-dimensional (3D) scaffolds from silk fibroin (SF) and functionalized (amidated and oxidized) citrus pectin (PEC) were developed for skin tissue engineering applications. Crosslinking was achieved by Schiff's reaction in borax presence as crosslinking coordinating agent and CaCl2 addition. After freeze-drying and methanol treatment, plasma treatment (10 W, 3 min) was applied to remove surface skin layer formed on scaffolds. 3D matrices had high porosity (83%) and interconnectivity with pore size about 120 µm that providing suitable microenvironment for cells. Modifications on PEC chai...
Source: Biomed Res - January 23, 2018 Category: Research Authors: Türkkan S, Atila D, Akdağ A, Tezcaner A Tags: J Biomed Mater Res B Appl Biomater Source Type: research

Synthesis and Characterization of Biogenic Selenium Nanoparticles with Antimicrobial Properties Made by Staphylococcus aureus, Methicillin-resistant Staphylococcus aureus (MRSA), Escherichia coli and Pseudomonas aeruginosa.
This article is protected by copyright. All rights reserved. PMID: 29356322 [PubMed - as supplied by publisher] (Source: Biomed Res)
Source: Biomed Res - January 22, 2018 Category: Research Authors: Medina Cruz D, Mi G, Webster TJ Tags: J Biomed Mater Res A Source Type: research

Incorporation of bacteriophages in polycaprolactone/collagen fibers for antibacterial hemostatic dual-function.
Abstract Effective and affordable, antibacterial and hemostatic materials are of great interests in clinical wound care practices. Herein, Enterobacteria phage T4 were incorporated in polycaprolactone/collagen I (PCL-ColI) nanofibers via electrospinning in order to eradicate Escherichia coli infection and meanwhile establish hemostasis. Tensile strength of the membrane was significantly enhanced with increased PCL ratio. Those with a collagen component above 70% were demonstrated to be more hemostatic with shorter hemostatic time and smaller amount of bleeding. On the other hand, the T4 phage incorporated PCL-ColI...
Source: Biomed Res - January 22, 2018 Category: Research Authors: Cheng W, Zhang Z, Xu R, Cai P, Kristensen P, Chen M, Huang Y Tags: J Biomed Mater Res B Appl Biomater Source Type: research

Biomechanical analysis of decellularized dermis and skin: Initial in vivo observations using OCT and vibrational analysis.
This article is protected by copyright. All rights reserved. PMID: 29356381 [PubMed - as supplied by publisher] (Source: Biomed Res)
Source: Biomed Res - January 22, 2018 Category: Research Authors: Shah RG, DeVore D, Silver FH Tags: J Biomed Mater Res A Source Type: research

S-nitrosated poly(propylene sulfide) nanoparticles for enhanced nitric oxide delivery to lymphatic tissues.
This article is protected by copyright. All rights reserved. PMID: 29352735 [PubMed - as supplied by publisher] (Source: Biomed Res)
Source: Biomed Res - January 20, 2018 Category: Research Authors: Schudel A, Sestito LF, Thomas SN Tags: J Biomed Mater Res A Source Type: research

The in vitro release of cytokines and growth factors from fibrin membranes produced through horizontal centrifugation.
This article is protected by copyright. All rights reserved. PMID: 29345045 [PubMed - as supplied by publisher] (Source: Biomed Res)
Source: Biomed Res - January 18, 2018 Category: Research Authors: Lourenço ES, Mourão CFAB, Leite PEC, Granjeiro JM, Calasans-Maia MD, Alves GG Tags: J Biomed Mater Res A Source Type: research

Self-production of oxygen system CaO2 /MnO2 @PDA-MB for the photodynamic therapy research and switch-control tumor cell imaging.
Abstract Photodynamic therapy (PDT) holds promise in biochemical study and tumor treatment. A novel multifunctional nanosystem CaO2 /MnO2 @polydopamine (PDA)-methylene blue (MB) nanosheet (CMP-MB) was designed. CaO2 nanoparticles were encapsulated by MnO2 nanosheet, and then PDA was coated on the surface of CaO2 /MnO2 nanosheets, which could adsorb photosensitizer MB through hydrophobic interaction or π-π stacking. In this nanosystem, CaO2 /MnO2 had the ability of self-production of oxygen, which solved the problem of tumor hypoxia largely. Moreover, it is worth mentioning that the fluorescence of MB was sup...
Source: Biomed Res - January 18, 2018 Category: Research Authors: Ji C, Lu Z, Xu Y, Shen B, Yu S, Shi D Tags: J Biomed Mater Res B Appl Biomater Source Type: research

Biomechanical, histological and computed X-ray tomographic analyses of hydroxyapatite coated PEEK implants in an extended healing model in rabbit.
PMID: 29341426 [PubMed - as supplied by publisher] (Source: Biomed Res)
Source: Biomed Res - January 17, 2018 Category: Research Authors: Johansson P, Barkarmo S, Hawthan M, Peruzzi N, Kjellin P, Wennerberg A Tags: J Biomed Mater Res A Source Type: research

Recombinant collagen scaffolds as substrates for human neural stem/progenitor cells.
This article is protected by copyright. All rights reserved. PMID: 29341434 [PubMed - as supplied by publisher] (Source: Biomed Res)
Source: Biomed Res - January 17, 2018 Category: Research Authors: Que RA, Arulmoli J, Da Silva NA, Flanagan LA, Wang SW Tags: J Biomed Mater Res A Source Type: research

Development of a bi-modal, in situ crosslinking method to achieve multi-factor release from electrospun gelatin.
This article is protected by copyright. All rights reserved. PMID: 29341492 [PubMed - as supplied by publisher] (Source: Biomed Res)
Source: Biomed Res - January 17, 2018 Category: Research Authors: Kishan AP, Walker T, Sears N, Wilems T, Cosgriff-Hernandez EM Tags: J Biomed Mater Res A Source Type: research

Smartphone App Using Mindfulness Meditation for Women With Chronic Pelvic Pain (MEMPHIS): Protocol for a Randomized Feasibility Trial.
CONCLUSIONS: This feasibility trial will inform the design of a large multicentered trial to assess the clinical effectiveness of mindfulness meditation delivered via a smartphone app for the treatment of CPP. TRIAL REGISTRATION: ClinicalTrials.gov: NCT02721108; https://clinicaltrials.gov/ct2/show/NCT02721108 (Archived by WebCite at http://www.webcitation.org/6wLMAkuaU); BioMed Central: ISRCTN10925965; https://www.isrctn.com/ISRCTN10925965 (Archived by WebCite at http://www.webcitation.org/6wLMVLuys). PMID: 29335232 [PubMed] (Source: Biomed Res)
Source: Biomed Res - January 15, 2018 Category: Research Authors: Ball E, Newton S, Kahan BC, Forbes G, Wright N, Cantalapiedra Calvete C, Gibson HAL, Rogozinska E, Rivas C, Taylor SJC, Birch J, Dodds J Tags: JMIR Res Protoc Source Type: research

Hydrophobic and Hydrophilic Effects on Water Structuring and Adhesion in Denture Adhesives.
This article is protected by copyright. All rights reserved. PMID: 29330941 [PubMed - as supplied by publisher] (Source: Biomed Res)
Source: Biomed Res - January 13, 2018 Category: Research Authors: Gill SK, Roohpour N, An Y, Gautrot JE, Topham PD, Tighe BJ Tags: J Biomed Mater Res A Source Type: research

Enhanced chondrogenesis of mesenchymal stem cells over silk fibroin/chitosan-chondroitin sulfate three dimensional scaffold in dynamic culture condition.
This study successfully demonstrates the potentiality of SF/CS-Ch scaffold for hMSCs recruitment and redirecting cartilage tissue regeneration with enhanced chondrogenesis. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2018. PMID: 29331090 [PubMed - as supplied by publisher] (Source: Biomed Res)
Source: Biomed Res - January 13, 2018 Category: Research Authors: Agrawal P, Pramanik K, Vishwanath V, Biswas A, Bissoyi A, Patra PK Tags: J Biomed Mater Res B Appl Biomater Source Type: research

Surface modification using the biomimetic method in alumina-zirconia porous ceramics obtained by the replica method.
Abstract The modification of biomaterials approved by the Food and Drug Administration could be an alternative to reduce the period of use in humans. Porous bioceramics are widely used as support structures for bone formation and repair. This composite has essential characteristics for an implant, including good mechanical properties, high chemical stability, biocompatibility and adequate aesthetic appearance. Here, three-dimensional porous scaffolds of Al2 O3 containing 5% by volume of ZrO2 were produced by the replica method. These scaffolds had their surfaces chemically treated with phosphoric acid and were coa...
Source: Biomed Res - January 12, 2018 Category: Research Authors: Silva ADR, Rigoli WR, Osiro D, Mello DCR, Vasconcellos LMR, Lobo AO, Pallone EMJA Tags: J Biomed Mater Res B Appl Biomater Source Type: research

The Effect of Cell Density, Proximity, and Time on the Cytotoxicity of Magnesium and Galvanically Coupled Magnesium-Titanium Particles in Vitro.
This study further investigated the in vitro cytotoxicity of Mg and Mg-Ti in terms of particle concentration, cell density, time, and proximity. Cell density has an effect on cell viability only at low particle concentrations (below 250 µg/ml), where cell viability dropped only for lower cell densities (5,000-10,000 cells/cm2 ) and not for higher cell densities (20,000-30,000 cells/cm2 ), showing that the particles cannot kill if there are more cells present. Cytotoxicity of Mg and Mg-Ti particles is quick and temporary, where the particles kill cells only during particle corrosion (first 24 hours). Depending on the ...
Source: Biomed Res - January 11, 2018 Category: Research Authors: Kim J, Gilbert JL Tags: J Biomed Mater Res A Source Type: research

Material dependent fretting corrosion in spinal fusion devices: Evaluation of onset and long-term response.
Abstract Posterior spinal fusion implants include number of interconnecting components, which are subjected to micromotion under physiological loading conditions inducing a potential for fretting corrosion. There is very little known about the fretting corrosion in these devices in terms of the minimum angular displacement (threshold) necessary to induce fretting corrosion or the amount of fretting corrosion that can arise during the life of the implant. Therefore, the first goal was to evaluate the threshold fretting corrosion in three anatomical orientations and second the long-term fretting corrosion for the th...
Source: Biomed Res - January 10, 2018 Category: Research Authors: Singh V, Shorez JP, Mali SA, Hallab NJ, Gilbert JL Tags: J Biomed Mater Res B Appl Biomater Source Type: research

Preclinical evaluation of melanocyte transplantation by chitosan-based melanocyte spheroid patch to skin prepared by controlled sunburn blistering.
Abstract Transplantation of autologous cultured melanocytes as cell suspension has been used for the treatment of vitiligo. The recipient site is often prepared by laser-mediated dermabrasion. Such procedures encounter disadvantages including prolonged transplantation duration, unsecured cell adherence to lesional skin and potential scarring. To improve this, here we propose a method by preparing recipient sites before transplantation by psoralen and ultraviolet A (PUVA)-induced sunburn followed by transplanting cells with a chitosan-based melanocyte spheroid patch. We evaluated the method in nude mice. Applicatio...
Source: Biomed Res - January 10, 2018 Category: Research Authors: Fan SM, Chen PH, Tseng YT, Hong JB, Chen W, Tsai TF, Lin SJ Tags: J Biomed Mater Res B Appl Biomater Source Type: research

Immunoisolating poly(ethylene glycol) based capsules support ovarian tissue survival to restore endocrine function.
This study demonstrated for the first time that immunoisolating PEG-VS capsules can support ovarian follicular development resulting in the restoration of ovarian endocrine function and can be applied to future allogeneic studies. This article is protected by copyright. All rights reserved. PMID: 29318744 [PubMed - as supplied by publisher] (Source: Biomed Res)
Source: Biomed Res - January 10, 2018 Category: Research Authors: Day JR, David A, Cichon AL, Kulkarni T, Cascalho M, Shikanov A Tags: J Biomed Mater Res A Source Type: research

Use of instrumented indentation for determination of mechanical properties of human cornea after UVA crosslinking.
This article is protected by copyright. All rights reserved. PMID: 29318768 [PubMed - as supplied by publisher] (Source: Biomed Res)
Source: Biomed Res - January 10, 2018 Category: Research Authors: Nohava J, Swain M, Lang SJ, Maier P, Heinzelmann S, Reinhard T, Eberwein P Tags: J Biomed Mater Res A Source Type: research

Phosphonate-functionalized poly( β-amino ester) macromers as potential biomaterials.
This article is protected by copyright. All rights reserved. PMID: 29318781 [PubMed - as supplied by publisher] (Source: Biomed Res)
Source: Biomed Res - January 10, 2018 Category: Research Authors: Akyol E, Tatliyuz M, Demir Duman F, Guven MN, Acar HY, Avci D Tags: J Biomed Mater Res A Source Type: research

Modeling Unobserved Heterogeneity in Susceptibility to Ambient Benzo[a]pyrene Concentration among Children with Allergic Asthma Using an Unsupervised Learning Algorithm.
hoi H Abstract Current studies of gene × air pollution interaction typically seek to identify unknown heritability of common complex illnesses arising from variability in the host's susceptibility to environmental pollutants of interest. Accordingly, a single component generalized linear models are often used to model the risk posed by an environmental exposure variable of interest in relation to a priori determined DNA variants. However, reducing the phenotypic heterogeneity may further optimize such approach, primarily represented by the modeled DNA variants. Here, we reduce phenotypic heterogeneity of ast...
Source: Biomed Res - January 10, 2018 Category: Research Authors: Fernández D, Sram RJ, Dostal M, Pastorkova A, Gmuender H, Choi H Tags: Int J Environ Res Public Health Source Type: research

Formation of nanotubular tio2 structures with varied surface characteristics for biomaterial applications.
verría E F Abstract Nanotubular structures were generated on the surface of titanium c.p. by anodization technique in an aqueous solution of acetic acid (14% v/v) with different sources of fluoride ion (HF, NaF, NH4 F). The aim of using these three different compounds is to study the effect of the counterion (H+ , Na+ and NH4+ ) on the morphology, wettability and surface free energy of the modified surface. Nanotubes were generated at 10 and 15 V for each anodizing solution. To further improve surface characteristics, the samples were heat-treated at 600°C for 4 hours and at 560°C for 3 hours. SEM i...
Source: Biomed Res - January 9, 2018 Category: Research Authors: Aguirre R, Echeverry-Rendón M, Quintero D, Castaño JG, Harmsen MC, Robledo S, Echeverría E F Tags: J Biomed Mater Res A Source Type: research

Effect of bone sialoprotein coated three-dimensional printed calcium phosphate scaffolds on primary human osteoblasts.
n A Abstract The combination of the two techniques of rapid prototyping 3D-plotting and bioactive surface functionalization is presented, with emphasis on the in vitro effect of Bone Sialoprotein (BSP) on primary human osteoblasts (hOBs). Our primary objective was to demonstrate the BSP influence on the expression of distinctive osteoblast markers in hOBs. Secondary objectives included examinations of the scaffolds' surface and the stability of BSP-coating as well as investigations of cell viability and proliferation. 3D-plotted calcium phosphate cement (CPC) scaffolds were coated with BSP via physisorption. hOBs ...
Source: Biomed Res - January 9, 2018 Category: Research Authors: Klein A, Baranowski A, Ritz U, Götz H, Heinemann S, Mattyasovszky S, Rommens PM, Hofmann A Tags: J Biomed Mater Res B Appl Biomater Source Type: research

Local administration of nuclear factor of activated T cells (NFAT) c1 inhibitor to suppress early resorption and inflammation induced by bone morphogenetic protein-2.
This study is a follow-up to our previous study showing the anti-resorptive activity of VIVIT, a peptide type NFATc1 inhibitor, using absorbable collagen sponge (ACS). This study aimed to investigate the effective concentration range of local VIVIT that suppresses early excessive osteoclast activation and inflammation induced by high-dose recombinant human bone morphogenetic protein (rhBMP)-2 and concomitantly enhances bone healing in a rat critical-sized calvaria defect model. High-dose rhBMP-2 (40 μg/defect) alone significantly increased in vivo osteoclast activation and expression of the inflammatory cytokines interl...
Source: Biomed Res - January 9, 2018 Category: Research Authors: Kim RY, Seong Y, Cho TH, Lee B, Kim IS, Hwang SJ Tags: J Biomed Mater Res A Source Type: research

Osteogenic cellular activity around onlaid octacalcium phosphate-gelatin composite onto rat calvaria.
This article is protected by copyright. All rights reserved. PMID: 29316231 [PubMed - as supplied by publisher] (Source: Biomed Res)
Source: Biomed Res - January 9, 2018 Category: Research Authors: Iwama R, Anada T, Shiwaku Y, Tsuchiya K, Takahashi T, Suzuki O Tags: J Biomed Mater Res A Source Type: research

Development and biocompatibility evaluation of biodegradable bacterial cellulose as a novel peripheral nerve scaffold.
This article is protected by copyright. All rights reserved. PMID: 29316233 [PubMed - as supplied by publisher] (Source: Biomed Res)
Source: Biomed Res - January 9, 2018 Category: Research Authors: Hou Y, Wang X, Yang J, Zhu R, Zhang Z, Li Y Tags: J Biomed Mater Res A Source Type: research

Composite porous scaffold of Polyethylene glycol (PEG)/Polylactic acid (PLA) support improved bone matrix deposition in vitro compared to PLA -only scaffolds.
This article is protected by copyright. All rights reserved. PMID: 29316238 [PubMed - as supplied by publisher] (Source: Biomed Res)
Source: Biomed Res - January 9, 2018 Category: Research Authors: Bhaskar B, Owen R, Bahmaee H, Wally Z, Sreenivasa Rao P, Reilly GC Tags: J Biomed Mater Res A Source Type: research

A 3D Bioprinted In Situ Conjugated-co-Fabricated Scaffold for Potential Bone Tissue Engineering Applications.
This article is protected by copyright. All rights reserved. PMID: 29316290 [PubMed - as supplied by publisher] (Source: Biomed Res)
Source: Biomed Res - January 9, 2018 Category: Research Authors: Sithole MN, Kumar P, du Toit LC, Marimuthu T, Choonara YE, Pillay V Tags: J Biomed Mater Res A Source Type: research

Different compact hybrid Langmuir-Blodgett-film coatings modify biomineralization and the ability of osteoblasts to grow.
Abstract Calcium phosphates (CaPs) are biomaterials widely used in tissue regeneration with outstanding biological performance. Although the tremendous improvements achieved in CaP's materials research over the years, their interaction with physiological environments still need to be fully understood. The aim of this study is to explore a biomimetic Langmuir-Blodgett (LB) membrane to template the growth of hydroxyapatite (HAp) coatings on Ti surfaces and the ability of these coatings in inducing biomineralization by osteoblasts cultured in vitro. Changing the phospholipids (i.e., dihexadecyl phosphate (DHP) or oct...
Source: Biomed Res - January 4, 2018 Category: Research Authors: de Faria AN, Cruz MAE, Ruiz GCM, Zancanela DC, Ciancaglini P, Ramos AP Tags: J Biomed Mater Res B Appl Biomater Source Type: research

Cyclotriphosphate associated to fluoride increases hydroxyapatite resistance to acid attack.
This study evaluated the effect of sodium trimetaphosphate (TMP) associated or not with fluoride (F) on the structure and dissolution of carbonated hydroxyapatite (CHA). Synthetic CHA powder (1.0 g) was suspended in solutions containing TMP at 0-10%, associated with 0, 1100, 4500, or 9000 ppm F, and the precipitates were submitted to a pH cycle (n = 6/group). Samples were analyzed by Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction. F, calcium (Ca) and phosphorous (P) concentrations were determined in CHA, while P and F were analyzed in the supernatants. Data were submitted to analysis of ...
Source: Biomed Res - January 4, 2018 Category: Research Authors: Amaral JG, Pessan JP, Souza JAS, Moraes JCS, Delbem ACB Tags: J Biomed Mater Res B Appl Biomater Source Type: research

Novel large-pore lightweight polypropylene mesh has better biocompatibility for rat model of hernia.
Abstract PURPOSE: Abdominal wall hernias are repaired with tension-free prosthetic materials but there remains a foreign body response (FBR) to commonly used polypropylene mesh. Thus, we should optimize mesh materials to improve the patient outcomes after surgery. MATERIALS AND METHODS: A polypropylene mesh was developed with wrap knitting technique. The physical, mechanical and biocompatible characteristics were tested in a rat abdominal hernia model and compared to ULTRAPRO and Easy Prosthesis. RESULTS: Polypropylene mesh of two pore sizes was developed (LP-WKPM and SP-WKPM). Compared with ULTRAPRO and...
Source: Biomed Res - January 3, 2018 Category: Research Authors: Qiu W, Zhong C, Xu R, Zou T, Wang F, Fan Y, Wang L, Yang Z Tags: J Biomed Mater Res A Source Type: research

Alternative Foaming Agents for Topical Treatment of Ulcerative Colitis.
This article is protected by copyright. All rights reserved. PMID: 29314587 [PubMed - as supplied by publisher] (Source: Biomed Res)
Source: Biomed Res - January 3, 2018 Category: Research Authors: Asama M, Hall A, Qi Y, Moreau B, Walthier H, Schaschwary M, Bristow B, Wang Q Tags: J Biomed Mater Res A Source Type: research

In vivo immuno-reactivity analysis of the porous 3D CS/SiO2 and CS/SiO2 /HA hybrids.
This article is protected by copyright. All rights reserved. PMID: 29314593 [PubMed - as supplied by publisher] (Source: Biomed Res)
Source: Biomed Res - January 3, 2018 Category: Research Authors: Guo M, Dong Y, Xiao J, Gu R, Ding M, Huang T, Li J, Zhao N, Liao H Tags: J Biomed Mater Res A Source Type: research

Fabrication and Characterization of Polymer- Ceramic Nanocomposites containing Drug Loaded Modified Halloysite Nanotubes.
This article is protected by copyright. All rights reserved. PMID: 29314595 [PubMed - as supplied by publisher] (Source: Biomed Res)
Source: Biomed Res - January 3, 2018 Category: Research Authors: Ghaderi-Ghahfarrokhi M, Haddadi-Asl V, Zargarian SS Tags: J Biomed Mater Res A Source Type: research

3D extrusion bioprinting of single- and double-network hydrogels containing dynamic covalent crosslinks.
This article is protected by copyright. All rights reserved. PMID: 29314616 [PubMed - as supplied by publisher] (Source: Biomed Res)
Source: Biomed Res - January 3, 2018 Category: Research Authors: Wang LL, Highley CB, Yeh YC, Galarraga JH, Uman S, Burdick JA Tags: J Biomed Mater Res A Source Type: research

Genipin-cross-linked type II collagen scaffold promotes the differentiation of adipose-derived stem cells into nucleus pulposus-like cells.
This article is protected by copyright. All rights reserved. PMID: 29314724 [PubMed - as supplied by publisher] (Source: Biomed Res)
Source: Biomed Res - January 3, 2018 Category: Research Authors: Zhou X, Tao Y, Chen E, Wang J, Fang W, Zhao T, Liang C, Li F, Chen Q Tags: J Biomed Mater Res A Source Type: research

Preparation of fluoride-loaded microcapsules for anticariogenic bacterial growth using a coaxial ultrasonic atomizer.
Abstract A new method to deliver fluoride using biodegradable poly(lactic-co-glycolic acid) microcapsules to suppress cariogenic bacterial growth during orthodontic treatment was investigated. A coaxial ultrasonic atomizer was used to encapsulate KF solution into microcapsules. The orthodontic adhesive resin disk containing fluoride loaded microcapsules (DFLM) was prepared by LED light curing. The microstructure of microcapsules, successful loading of KF, fracture strength, and shear bonding strength were assessed by FE-SEM, confocal laser scanning microscope, and general purpose testing machine, respectively. Flu...
Source: Biomed Res - December 10, 2017 Category: Research Authors: Choi HW, Um SH, Rhee SH Tags: J Biomed Mater Res B Appl Biomater Source Type: research

The combined effect of thermal and chemotherapy on HeLa cells using magnetically actuated smart textured fibrous system.
Abstract Thermal therapy combined with chemotherapy is one of the advanced and efficient methods to eradicate cancer. In this work, we fabricated magnetically actuated smart textured (MAST) fibrous systems and studied their candidacy for cancer treatment. The polycaprolactone-Fe3 O4 based MAST fibers were fabricated using electrospinning technique. These MAST fibrous systems contained carbogenic quantum dots as a tracking agent and doxorubicin hydrochloride anticancer drug. Additionally, as fabricated MAST fibrous systems were able to deliver anticancer drug and heat energy simultaneously to kill HeLa cells in a 1...
Source: Biomed Res - December 10, 2017 Category: Research Authors: Tiwari P, Agarwal S, Srivastava S, Jain S Tags: J Biomed Mater Res B Appl Biomater Source Type: research

In vitro and in vivo study of commercial calcium phosphate cement HydroSet ™.
In vitro and in vivo study of commercial calcium phosphate cement HydroSet™. J Biomed Mater Res B Appl Biomater. 2018 Jan;106(1):21-30 Authors: Kent NW, Blunn G, Karpukhina N, Davis G, de Godoy RF, Wilson RM, Coathup M, Onwordi L, Quak WY, Hill R Abstract The commercial calcium phosphate cement, HydroSet™, was investigated in vitro, studying phase formation, compressive strength and setting time, followed by an ovine in vivo study to measure osseointegration, bone apposition and bone-to-graft contact. The X-ray diffraction and 31 P Magic Angle Spinning Nuclear Magnetic Resonance (MAS NMR) ...
Source: Biomed Res - December 10, 2017 Category: Research Authors: Kent NW, Blunn G, Karpukhina N, Davis G, de Godoy RF, Wilson RM, Coathup M, Onwordi L, Quak WY, Hill R Tags: J Biomed Mater Res B Appl Biomater Source Type: research

Exploration of the Association between Nurses' Moral Distress and Secondary Traumatic Stress Syndrome: Implications for Patient Safety in Mental Health Services.
Abstract Work-related moral distress (MD) and secondary traumatic stress syndrome (STSS) may be associated with compromised health status among health professionals, reduced productivity, and inadequate safety of care. We explored the association of MD with the severity of STSS symptoms, along with the mediating role of mental distress symptoms. Associations with emotional exhaustion and professional satisfaction were also assessed. This cross-sectional survey conducted in 206 mental health nurses (MHNs) was employed across public sector community and hospital settings in Cyprus. The analysis revealed that MD (mea...
Source: Biomed Res - December 8, 2017 Category: Research Authors: Christodoulou-Fella M, Middleton N, Papathanassoglou EDE, Karanikola MNK Tags: Biomed Res Int Source Type: research

MYC Gene Rearrangements Are Closely Associated with Poor Survival of Diffuse Large B Cell Lymphoma with Hepatitis B Virus Infection.
In this study, 30 DLBCL patients with HBV infection and 51 DLBCL patients with HBV-free were reviewed retrospectively. As of July 2016, the median follow-up period was 26.4 months (3.0~65.0 months). The median OS of patients in HBV infection group was 38.6 months, while that of patients in HBV-free group was not reached (P = 0.042); the median progression-free survival (PFS) of patients in HBV infection group was worse than that in HBV-free group, 18.5 months and 38.5 months (P = 0.118), respectively. The rate of MYC and BCL2 gene rearrangements in HBV infection group was significantly higher than that in HBV-free group, 2...
Source: Biomed Res - December 8, 2017 Category: Research Authors: Liu Z, Li S, Guo W, Wang Y, Wang M, Bai O Tags: Biomed Res Int Source Type: research

In Vitro Antibacterial Activity of Pomegranate Juice and Peel Extracts on Cariogenic Bacteria.
Conclusions: In vitro microbiological tests demonstrate that the hydroalcoholic extracts of pomegranate juice and peel are able to contrast the main cariogenic bacteria involved in tooth decay. Although being preliminary data, our results suggest that pomegranate polyphenolic compounds could represent a good adjuvant for the prevention and treatment of dental caries. PMID: 29209624 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - December 8, 2017 Category: Research Authors: Ferrazzano GF, Scioscia E, Sateriale D, Pastore G, Colicchio R, Pagliuca C, Cantile T, Alcidi B, Coda M, Ingenito A, Scaglione E, Cicatiello AG, Volpe MG, Di Stasio M, Salvatore P, Pagliarulo C Tags: Biomed Res Int Source Type: research

Prediction and Validation of Hub Genes Associated with Colorectal Cancer by Integrating PPI Network and Gene Expression Data.
In conclusion, the four hub genes screened by our strategy could serve as novel biomarkers for prognosis prediction of CRC patients. PMID: 29209625 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - December 8, 2017 Category: Research Authors: Xiong Y, You W, Wang R, Peng L, Fu Z Tags: Biomed Res Int Source Type: research

Neovascular Prostate-Specific Membrane Antigen Expression Is Associated with Improved Overall Survival under Palliative Chemotherapy in Patients with Pancreatic Ductal Adenocarcinoma.
Huss S Abstract Aims: Expression of PSMA (prostate-specific membrane antigen) has been demonstrated in various cancers, including pancreatic ductal adenocarcinoma (PDAC). However, PSMA expression in PDAC-associated neovasculature has so far not been systematically analyzed. Methods and Results: We analyzed PSMA expression in 81 PDAC tissue samples from 61 patients. Microvessel density (MVD) was assessed by software-based image analysis and showed a mean MVD of 63.7 microvessels/0.785 mm2. PSMA was practically absent in tumor tissue (5.3%) and PDAC cell lines (0/7) but could be detected i...
Source: Biomed Res - December 8, 2017 Category: Research Authors: Stock K, Steinestel K, Wiesch R, Mikesch JH, Hansmeier A, Trautmann M, Beller N, Rehkämper J, Wardelmann E, Heitkötter B, Hartmann W, Sperveslage J, Huss S Tags: Biomed Res Int Source Type: research

Thermosensitive Chitosan Hydrogels Containing Polymeric Microspheres for Vaginal Drug Delivery.
Abstract Thermosensitive hydrogels have increasingly received considerable attention for local drug delivery based on many advantages. However, burst release of drugs is becoming a critical challenge when the hydrogels are employed. Microspheres- (MS-) loaded thermosensitive hydrogels were thus fabricated to address this limitation. Employing an orthogonal design, the spray-dried operations of tenofovir (TFV)/Bletilla striata polysaccharide (BSP)/chitosan (CTS) MS were optimized according to the drug loading (DL). The physicochemical properties of the optimal MS (MS F) were characterized. Depending on the gelation...
Source: Biomed Res - December 8, 2017 Category: Research Authors: Yang TT, Cheng YZ, Qin M, Wang YH, Yu HL, Wang AL, Zhang WF Tags: Biomed Res Int Source Type: research

Inhibitors of Histone Deacetylases Are Weak Activators of the FMR1 Gene in Fragile X Syndrome Cell Lines.
Abstract Fragile X syndrome is the most common cause of inherited intellectual disability in humans. It is a result of CGG repeat expansion in the 5' untranslated region (5' UTR) of the FMR1 gene. This gene encodes the FMRP protein that is involved in neuronal development. Repeat expansion leads to heterochromatinization of the promoter, gene silencing, and the subsequent absence of FMRP. To date, there is no specific therapy for the syndrome. All treatments in clinic practice provide symptomatic therapy. The development of drug therapy for Fragile X syndrome treatment is connected with the search for inhibitors o...
Source: Biomed Res - December 8, 2017 Category: Research Authors: Dolskiy AA, Pustylnyak VO, Yarushkin AA, Lemskaya NA, Yudkin DV Tags: Biomed Res Int Source Type: research

Corrigendum to "Effects of Chronic Exposure to Sodium Arsenite on Expressions of VEGF and VEGFR2 Proteins in the Epididymis of Rats".
Corrigendum to "Effects of Chronic Exposure to Sodium Arsenite on Expressions of VEGF and VEGFR2 Proteins in the Epididymis of Rats". Biomed Res Int. 2017;2017:4284156 Authors: Yan-Ping D, Xiao-Qin G, Xiao Ping M, Ying Quan Y Abstract [This corrects the article DOI: 10.1155/2017/2597256.]. PMID: 29209629 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - December 8, 2017 Category: Research Authors: Yan-Ping D, Xiao-Qin G, Xiao Ping M, Ying Quan Y Tags: Biomed Res Int Source Type: research

Barriers to Physical Activity in Low Back Pain Patients following Rehabilitation: A Secondary Analysis of a Randomized Controlled Trial.
Conclusions: Low back pain patients especially with a low level of education and fear of pain seem to need tailored support in overcoming barriers to physical activity. This study is registered at German Clinical Trials Register (DRKS00004878). PMID: 29209630 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - December 8, 2017 Category: Research Authors: Schaller A, Exner AK, Schroeer S, Kleineke V, Sauzet O Tags: Biomed Res Int Source Type: research

Maxillary Sinus Floor Augmentation Using an Equine-Derived Graft Material: Preliminary Results in 17 Patients.
Conclusion: Within the limitations of this study, this equine-derived bone graft proved to be an effective material to induce new bone formation in the sinus floor elevation procedure. PMID: 29209631 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - December 8, 2017 Category: Research Authors: Rivara F, Negri M, Lumetti S, Parisi L, Toffoli A, Calciolari E, Manfredi E, Macaluso GM Tags: Biomed Res Int Source Type: research