Identification of Specific Cell Subpopulations and Marker Genes in Ovarian Cancer Using Single-Cell RNA Sequencing
Biomed Res Int. 2021 Oct 7;2021:1005793. doi: 10.1155/2021/1005793. eCollection 2021.ABSTRACTOBJECTIVE: Ovarian cancer is the deadliest gynaecological cancer globally. In our study, we aimed to analyze specific cell subpopulations and marker genes among ovarian cancer cells by single-cell RNA sequencing (RNA-seq).METHODS: Single-cell RNA-seq data of 66 high-grade serous ovarian cancer cells were employed from the Gene Expression Omnibus (GEO). Using the Seurat package, we performed quality control to remove cells with low quality. After normalization, we detected highly variable genes across the single cells. Then, princip...
Source: Biomed Res - October 18, 2021 Category: Research Authors: Yan Li Juan Wang Fang Wang Chengzhen Gao Yuanyuan Cao Jianhua Wang Source Type: research

Seroprevalence of < em > Taenia solium < /em > and < em > Trichinella spiralis < /em > among Humans and Pigs in Ghana
This study also recorded a seroprevalence of 0.31% for Trichinella spp. for humans and a seroprevalence of 4.5% for Trichinella spp. for pigs. Again, all the samples that showed serological evidence of Trichinella spp. among pigs came from those pigs which were raised on the free-ranged system. Proper pig management practice is a very important tool for controlling these intestinal parasites in both humans and animals. This study recommends public health education among the general public and good pig farming practices.PMID:34660777 | PMC:PMC8519675 | DOI:10.1155/2021/1031965 (Source: Biomed Res)
Source: Biomed Res - October 18, 2021 Category: Research Authors: Henry Ofosu Addo Ayodele O Majekodunmi Eric Sampane-Donkor Lawrence Henry Ofosu-Appiah David Opare Godfred Owusu-Okyere Kingsley Ebenezer Amegah Langbong Bimi Source Type: research

Soluble B7-H5 Is a Novel Diagnostic, Severity, and Prognosis Marker in Acute Pancreatitis
In this study, the levels of sB7-H5 and cytokines in plasma samples of 75 AP patients, 20 abdominal pain patients without AP, and 20 healthy volunteers were determined. Then, the correlation of sB7-H5 and clinical features, cytokines, the Ranson score, APACHE II score, Marshall score, and BISAP score was analysed, and the value of sB7-H5 for diagnostic, severity, and prognosis of AP was evaluated. We found that the levels of sB7-H5 were specifically upregulated in AP patients. Receiver operating characteristic (ROC) analysis revealed that sB7-H5 can identify AP patients from healthy or abdominal pain patients with 78.9% or...
Source: Biomed Res - October 18, 2021 Category: Research Authors: Ruoxin Xu Ju Gong Wei Chen Yakang Jin Jian Huang Source Type: research

Synergistic Antiproliferative Effects of All-Trans Retinoic Acid and Paclitaxel on Autosomal Dominant Polycystic Kidney Disease Epithelial Cells
Biomed Res Int. 2021 Oct 6;2021:1242916. doi: 10.1155/2021/1242916. eCollection 2021.ABSTRACTAutosomal dominant polycystic kidney disease (ADPKD) is a genetic disorder characterized by uncontrollable epithelial cell growth, cyst formation, and kidney malfunction. In the present study, we investigated the antiproliferative effects of the treatment with the combination of paclitaxel (PAC) and all-trans retinoic acid (ATRA) on ADPKD epithelial cells. Our results show that the combined treatment with 1 nM PAC and 10 nM ATRA significantly suppressed ADPKD cell proliferation (20%), while the treatment with ATRA or PAC alone had ...
Source: Biomed Res - October 18, 2021 Category: Research Authors: Que Thanh Thanh Nguyen Thi Xoan Hoang Hyunjin Ryu Kook-Hwan Oh Jae Young Kim Source Type: research

Effect of 1,25-Dihydroxyvitamin D3 on Stem Cells from Human Apical Papilla: Adhesion, Spreading, Proliferation, and Osteogenic Differentiation
In this study, we investigated the role of 1,25-dihydroxyvitamin D3 in regulating the adhesion, spreading, proliferation, and osteogenic differentiation of SCAP, laying the foundation for subsequent clinical drug development. The immature tooth samples were collected in clinical treatment. SCAPs with stable passage ability were isolated and cultured. The multidifferentiation potential was determined by directed induction culture, while the stem cell characteristics were identified by flow cytometry. There were three groups: group A-SCAPs general culture group; group B-SCAPs osteogenesis induction culture group; and group C...
Source: Biomed Res - October 18, 2021 Category: Research Authors: Yonggang Ma Jiaojiao Yang Yan Li Lijie Sun Zhuyun Liu Jia Qian Lizhong Wang Delin Xia Source Type: research

Critical Involvement of Glial Cells in Manganese Neurotoxicity
Biomed Res Int. 2021 Oct 6;2021:1596185. doi: 10.1155/2021/1596185. eCollection 2021.ABSTRACTOver the years, most of the research concerning manganese exposure was restricted to the toxicity of neuronal cells. Manganese is an essential trace element that in high doses exerts neurotoxic effects. However, in the last two decades, efforts have shifted toward a more comprehensive approach that takes into account the involvement of glial cells in the development of neurotoxicity as a brain insult. Glial cells provide structural, trophic, and metabolic support to neurons. Nevertheless, these cells play an active role in adult ne...
Source: Biomed Res - October 18, 2021 Category: Research Authors: Jazm ín Soto-Verdugo Arturo Ortega Source Type: research

Network Pharmacology-Based and Molecular Docking-Based Analysis of Suanzaoren Decoction for the Treatment of Parkinson's Disease with Sleep Disorder
This study is aimed at exploring the possible mechanism of action of the Suanzaoren decoction (SZRD) in the treatment of Parkinson's disease with sleep disorder (PDSD) based on network pharmacology and molecular docking. Traditional Chinese Medicine Systems Pharmacology (TCMSP) was used to screen the bioactive components and targets of SZRD, and their targets were standardized using the UniProt platform. The disease targets of "Parkinson's disease (PD)" and "Sleep disorder (SD)" were collected by OMIM, GeneCards, and DisGeNET databases. Thereafter, the protein-protein interaction (PPI) network was const...
Source: Biomed Res - October 18, 2021 Category: Research Authors: Yan-Yun Liu Li-Hua Yu Juan Zhang Dao-Jun Xie Xin-Xiang Zhang Jia-Ming Yu Source Type: research

Bioinformatics Analysis of ZBTB16 as a Prognostic Marker for Ewing's Sarcoma
CONCLUSIONS: High expression of ZBTB16 may serve as a predictor biomarker of poor prognosis in ES patients.PMID:34660783 | PMC:PMC8514890 | DOI:10.1155/2021/1989917 (Source: Biomed Res)
Source: Biomed Res - October 18, 2021 Category: Research Authors: Ke Ding Wenli Qiu Dianbo Yu Huade Ma Kangqi Xie Fuqiang Luo Shanlang Li Zaiyong Li Jihua Wei Source Type: research

The Role of General Anesthetic Drug Selection in Cancer Outcome
Biomed Res Int. 2021 Oct 7;2021:2563093. doi: 10.1155/2021/2563093. eCollection 2021.ABSTRACTCancer remains to be the leading cause of death globally. Surgery is a mainstay treatment for solid tumors. Thus, it is critical to optimize perioperative care. Anesthesia is a requisite component for surgical tumor resection, and general anesthesia is given in the vast majority of tumor resection cases. Because anesthetics are growingly recognized as immunomodulators, it is critical to optimize anesthetic regimens for cancer surgery if the selection can affect outcomes. Here, we reviewed the role of volatile and intravenous anesth...
Source: Biomed Res - October 18, 2021 Category: Research Authors: Koichi Yuki Source Type: research

The Study of Field Equivalence Determined by the Modeled Percentage Depth Dose in Electron Beam Radiation Therapy
CONCLUSIONS: The PDD of the electron beam at different energies and cone sizes can be modeled with an empirical model to deal with what is the minimal field size without changing the percent depth dose when approximate LSE is given in centimeters of water.PMID:34660785 | PMC:PMC8519681 | DOI:10.1155/2021/3397350 (Source: Biomed Res)
Source: Biomed Res - October 18, 2021 Category: Research Authors: You-Guo Ma Yan-Shan Zhang Yan-Cheng Ye Jia-Ming Wu Source Type: research

Relationship between Urinary AD7c-NTP with Cerebral Microbleeds Based on APOE Genotype
CONCLUSION: A higher level of urinary AD7c-NTP is involved in lobar CMBs, not deep CMBs.PMID:34660786 | PMC:PMC8519669 | DOI:10.1155/2021/3928060 (Source: Biomed Res)
Source: Biomed Res - October 18, 2021 Category: Research Authors: None Yong-Peng Yu Ya-Li Zheng Source Type: research

< em > Salmonella < /em > from Farm to Table: Isolation, Characterization, and Antimicrobial Resistance of < em > Salmonella < /em > from Commercial Broiler Supply Chain and Its Environment
Biomed Res Int. 2021 Oct 6;2021:3987111. doi: 10.1155/2021/3987111. eCollection 2021.ABSTRACTAntimicrobial resistance (AMR) in poultry production chain is one of the major food safety concerns due to indiscriminate usage of antibiotics and the presence of pathogens such as Salmonella which causes infections in various stages of production. In the present study, 182 samples were collected from commercial broiler supply chain, viz., three hatcheries (n = 29), three commercial broiler farms (CBF; n = 99), and three retail meat shops (RMS; n = 54), and used for isolation and identification of Salmonella using three different s...
Source: Biomed Res - October 18, 2021 Category: Research Authors: M Nasim Sohail D Rathnamma S Chandra Priya S Isloor H D Naryanaswamy S Wilfred Ruban B M Veeregowda Source Type: research

Methylation Modification, Alternative Splicing, and Noncoding RNA Play a Role in Cancer Metastasis through Epigenetic Regulation
Biomed Res Int. 2021 Oct 6;2021:4061525. doi: 10.1155/2021/4061525. eCollection 2021.ABSTRACTMetastasis is the leading cause of cancer-related deaths. Understanding the pathogenesis of metastasis at the molecular levels is of great significance for cancer research. However, the molecular diagnosis or treatment of cancer metastasis is limited. Accumulating and growing evidence shows that epigenetic changes are present in all human cancers, and epigenetic regulation is an indispensable factor to promote tumor metastasis. With the deepening of research and the advancement of technology, the function and mechanism of epigeneti...
Source: Biomed Res - October 18, 2021 Category: Research Authors: Bin Yu Xin Yu Jianping Xiong Mei Ma Source Type: research

Melatonin Suppresses Apoptosis of Nucleus Pulposus Cells through Inhibiting Autophagy via the PI3K/Akt Pathway in a High-Glucose Culture
In conclusion, melatonin attenuates apoptosis of NP cells through inhibiting the excessive autophagy via the PI3K/Akt pathway in a high-glucose culture. This study provides new theoretical basis of the protective effects of melatonin against disc degeneration in a DM patient.PMID:34660789 | PMC:PMC8519679 | DOI:10.1155/2021/4604258 (Source: Biomed Res)
Source: Biomed Res - October 18, 2021 Category: Research Authors: Jian Li Chengqiang Wang Lixin Xue Fan Zhang Jianqiang Liu Source Type: research

Vasorelaxant-Mediated Antihypertensive Effect of the Leaf Aqueous Extract from < em > Stephania abyssinica < /em > (Dillon & amp; A. Rich) Walp (Menispermaceae) in Rat
Biomed Res Int. 2021 Oct 8;2021:4730341. doi: 10.1155/2021/4730341. eCollection 2021.ABSTRACTStephania abyssinica is a medicinal plant used in Cameroon alternative medicine to treat arterial hypertension (AHT). Previous in vitro studies demonstrated the endothelium nitric oxide-independent vasorelaxant property of the aqueous extract from Stephania abyssinica (AESA). But its effect on AHT is unknown. The present study was undertaken to explore other vasorelaxant mechanisms and to determine the antihypertensive effects of AESA in male Wistar rats. Phytochemical analysis of AESA was carried out using the liquid chromatograph...
Source: Biomed Res - October 18, 2021 Category: Research Authors: Chamberlin Fodem Elvine Pami Nguelefack-Mbuyo Magloire Kanyou Ndjenda Ii Albert Kamanyi T élesphore Benoit Nguelefack Source Type: research

The Impact of Metformin Use with Survival Outcomes in Urologic Cancers: A Systematic Review and Meta-Analysis
Biomed Res Int. 2021 Oct 8;2021:5311828. doi: 10.1155/2021/5311828. eCollection 2021.ABSTRACTBACKGROUND: Conflicting results exist between the potential protective effects of metformin and the prognosis of urologic cancers. This meta-analysis summarized the effects of metformin exposure on the recurrence, progression, cancer-specific survival (CSS), and overall survival (OS) of the three main urologic cancers (kidney cancer, bladder cancer, and prostate cancer).METHODS: We systematically searched PubMed, Embase, Web of Science, Wanfang, and China National Knowledge Infrastructure databases (January 2010 to December 2019), ...
Source: Biomed Res - October 18, 2021 Category: Research Authors: Xiangyang Yao Haoran Liu Hua Xu Source Type: research

Impairment of Proprioception in Young Adult Nonradicular Patients with Lumbar Derangement Syndrome
Biomed Res Int. 2021 Oct 7;2021:5550257. doi: 10.1155/2021/5550257. eCollection 2021.ABSTRACTMaintaining body balance is a complex function based on the information deriving from the vestibular, visual, and proprioceptive systems. The aim of the study was to evaluate quiet single stance stability in young adults with lumbar derangement syndrome (LDS) and in the control group of the healthy subjects. The second aim of this study was to determine whether pain intensity, degree of disability, and the level of physical activity can influence postural control in patients with LDS. It is important to underline that selecting a h...
Source: Biomed Res - October 18, 2021 Category: Research Authors: Marzena Olszewska-Karaban Anna Permoda-Bia łozorczyk Aneta D ąbrowska Ewa Bandurska Andrzej Permoda Jolanta Zajt Agnieszka Sobierajska-Rek Dominika Szalewska Source Type: research

Phylogenetically Diverse < em > Escherichia coli < /em > Strains from Chicken Coharbor Multiple Carbapenemase-Encoding Genes ( < em > bla < /em > < sub > NDM < /sub > < em > -bla < /em > < sub > OXA < /sub > - < em > bla < /em > I < sub > MP < /sub > )
This study was conducted to investigate the occurrence, resistance patterns, and phylogenetic diversity of carbapenem-resistant E. coli (CREC) from chicken. Routine bacteriology, PCR detection of E. coli species, multiplex PCR to detect carbapenemase-encoding genes, and phylogeny of CRE E. coli were conducted. The results show that 24.36% (19/78) were identified as CREC based on the phenotypic identifications of which 17 were positive for the tested carbapenemases genes. The majority, 57.99% (11/19), of the isolates harbored multiple carbapenemase genes. Four isolates harbored all bla NDM, bla OXA, and bla IMP, and five an...
Source: Biomed Res - October 18, 2021 Category: Research Authors: Erkihun Aklilu Azian Harun Kirnpal Kaur Banga Singh Shamsaldeen Ibrahim Nor Fadhilah Kamaruzzaman Source Type: research

An Overview of miRNAs Involved in PASMC Phenotypic Switching in Pulmonary Hypertension
Biomed Res Int. 2021 Oct 7;2021:5765029. doi: 10.1155/2021/5765029. eCollection 2021.ABSTRACTPulmonary hypertension (PH) is occult, with no distinctive clinical manifestations and a poor prognosis. Pulmonary vascular remodelling is an important pathological feature in which pulmonary artery smooth muscle cells (PASMCs) phenotypic switching plays a crucial role. MicroRNAs (miRNAs) are a class of evolutionarily highly conserved single-stranded small noncoding RNAs. An increasing number of studies have shown that miRNAs play an important role in the occurrence and development of PH by regulating PASMCs phenotypic switching, w...
Source: Biomed Res - October 18, 2021 Category: Research Authors: Weifang Zhang Zeying Tao Fei Xu Qian Diao Juan Li Lu Zhou Yaxin Miao Shanshan Xie Jinjin Wan Ruilai Xu Source Type: research

Employees' Emotional, Cognitive, and Behavioral Responses to Increasing Statutory Retirement Ages
This study shows the importance of supportive contexts at different levels-societally, in organizations, and in individuals' own lives-for policy changes such as increasing statutory retirement ages to be effective. Different responses between different socioeconomic groups may lead to growing long-term inequality.PMID:34660795 | PMC:PMC8514891 | DOI:10.1155/2021/6645271 (Source: Biomed Res)
Source: Biomed Res - October 18, 2021 Category: Research Authors: Jaap Oude Mulders K ène Henkens Hendrik P van Dalen Source Type: research

The Effect and Safety of 5-HT < sub > 1F < /sub > Receptor Agonist Lasmiditan on Migraine: A Systematic Review and Meta-Analysis
CONCLUSIONS: Lasmiditan with the 50 mg, 100 mg, and 200 mg doses are effective and safe in acute migraine treatment. Lasmiditan 200 mg is more effective than lasmiditan 100 mg in pain freedom, while lasmiditan 100 mg is better tolerated in the short-term follow-up. Further larger sample-size RCTs are required to verify the applicability and tolerability in the long term.PMID:34660796 | PMC:PMC8517628 | DOI:10.1155/2021/6663591 (Source: Biomed Res)
Source: Biomed Res - October 18, 2021 Category: Research Authors: Ping Gu Cheng Chen Qian Wu Changhong Dong Teng Wang Qi Wan Xin Dong Source Type: research

Impact of Cervical Spine Rehabilitation on Temporomandibular Joint Functioning in Patients with Idiopathic Neck Pain
CONCLUSION: The study suggested that idiopathic neck pain is associated with limited range of motion in the cervical spine, incorrect head posture, and TMJ dysfunction. Our data suggests that therapy focusing only on the cervical region may improve the clinical condition of the TMJ in subjects with idiopathic neck pain who do not report TMJ pain. These observations could be helpful in physiotherapeutic treatment of neck and craniofacial area dysfunctions. This trial is registered with ISRCTN Registry ISRCTN14511735.PMID:34660797 | PMC:PMC8516540 | DOI:10.1155/2021/6886373 (Source: Biomed Res)
Source: Biomed Res - October 18, 2021 Category: Research Authors: Łukasz Oleksy Renata Kielnar Anna Mika Agnieszka Jankowicz-Szyma ńska Dorota Bylina Jaros ław Sołtan B łażej Pruszczyński Artur Stolarczyk Aleksandra Kr ólikowska Source Type: research

Privacy Protection and Secondary Use of Health Data: Strategies and Methods
Biomed Res Int. 2021 Oct 7;2021:6967166. doi: 10.1155/2021/6967166. eCollection 2021.ABSTRACTHealth big data has already been the most important big data for its serious privacy disclosure concerns and huge potential value of secondary use. Measurements must be taken to balance and compromise both the two serious challenges. One holistic solution or strategy is regarded as the preferred direction, by which the risk of reidentification from records should be kept as low as possible and data be shared with the principle of minimum necessary. In this article, we present a comprehensive review about privacy protection of healt...
Source: Biomed Res - October 18, 2021 Category: Research Authors: Dingyi Xiang Wei Cai Source Type: research

Coexpression Network Analysis of lncRNA Associated with Overexpression of DNMT1 in Esophageal Epithelial Cells
Biomed Res Int. 2021 Oct 8;2021:7162270. doi: 10.1155/2021/7162270. eCollection 2021.ABSTRACTScreening and preliminary identification of high DNMT1 expression-related lncRNA, which is involved in various interrelated signaling pathways, has led to the development of a theoretical basis for various types of disease mechanisms. Differential expression profiles of lncRNA and mRNA were identified in a microarray. Ten lncRNAs with high levels of variation were identified by qRT-PCR. KEGG and GO analyses were used to identify differentially expressed mRNAs. Six signaling pathways were selected based on the KEGG results of the ln...
Source: Biomed Res - October 18, 2021 Category: Research Authors: Yi Lei Yi Xu Xu-Feng Li Yan Chen Source Type: research

Feasibility and Effectiveness of the Web-Based WeActive and WeMindful Interventions on Physical Activity and Psychological Well-Being
This study is aimed at examining the feasibility and effectiveness of aerobic and resistance training (WeActive) and mindful exercise (WeMindful) interventions in improving physical activity (PA), psychological well-being (PWB), and subjective vitality among college students. Participants in this study were 77 college students who were randomly assigned to either the WeActive group (n = 43) or the WeMindful group (n = 28). The WeActive group attended two 30-minute aerobic and resistance training sessions per week, and the WeMindful group attended two 30-minute yoga and mindful exercise sessions per week for eight weeks. Al...
Source: Biomed Res - October 18, 2021 Category: Research Authors: Michele W Marenus Andy Murray Kathryn Friedman Julia Sanowski Haley Ottensoser Ana Cahuas Varun Kumaravel Weiyun Chen Source Type: research

Plasma Fatty Acid Composition Was Associated with Apelin Gene Expression in Human Adipose Tissues
In this study, we aimed to determine the association of the plasma fatty acid composition with apelin plasma concentration and gene expression in visceral (VAT) and subcutaneous (SAT) adipose tissues.METHODS: In this cross-sectional study, we recruited 179 patients aged 19-75 years who were candidates for elective surgery. Through the surgery, SAT and VAT were collected to measure apelin gene expression. Anthropometric measurements, fasting blood samples, and dietary intakes were collected before surgery. Free fatty acids (FFAs) in fasting whole plasma were measured using gas chromatography with flame ionization detection....
Source: Biomed Res - October 18, 2021 Category: Research Authors: Emad Yuzbashian Golaleh Asghari Nilofar Beheshti Mehdi Hedayati Maryam Zarkesh Parvin Mirmiran Afsoon Daneshafrooz Alireza Khalaj Source Type: research

Effectiveness of Different Modalities of Lip Repositioning Surgery for Management of Patients Complaining of Excessive Gingival Display: A Systematic Review and Meta-Analysis
CONCLUSIONS: Gingival display within the 6 months after LRS could be reduced with all modalities. Descriptively, the greatest reduction was observed in patients with the modality not including the frenulum.PMID:34660802 | PMC:PMC8516537 | DOI:10.1155/2021/9476013 (Source: Biomed Res)
Source: Biomed Res - October 18, 2021 Category: Research Authors: Shima Younespour Siamak Yaghobee Hoori Aslroosta Neda Moslemi Elham Pourheydar Elaha Somaya Ghafary Source Type: research

Logistic Regression Analysis of the Factors Involved in the Failure of Osseointegration and Survival of Dental Implants with an Internal Connection and Machined Collar: A 6-Year Retrospective Cohort Study
Biomed Res Int. 2021 Oct 7;2021:9684511. doi: 10.1155/2021/9684511. eCollection 2021.ABSTRACTBACKGROUND: Although the long-term success rate of dental implants is currently close to 95%, it is necessary to provide more evidence on the factors related to the failure of osseointegration and survival.PURPOSE: To establish the risk factors associated with the failure of osseointegration and survival of dental implants with an internal connection and machined collar and to establish a predictive statistical model.MATERIALS AND METHODS: An analytical, retrospective, and observational clinical study of a sample of 297 implants wi...
Source: Biomed Res - October 18, 2021 Category: Research Authors: Aritza Brizuela-Velasco Ángel Álvarez-Arenal Esteban P érez-Pevida Iker Bellanco-De La Pinta H éctor De Llanos-Lanchares Ignacio Gonz ález-González Carolina Larraz ábal-Morón Source Type: research

Probing the Peculiarity of < em > Eh < /em > RabX10, a pseudoRab GTPase, from the Enteric Parasite < em > Entamoeba histolytica < /em > through In Silico Modeling and Docking Studies
Biomed Res Int. 2021 Oct 6;2021:9913625. doi: 10.1155/2021/9913625. eCollection 2021.ABSTRACTEntamoeba histolytica (Eh) is a pathogenic eukaryote that often resides silently in humans under asymptomatic stages. Upon indeterminate stimulus, it develops into fulminant amoebiasis that causes severe hepatic abscesses with 50% mortality. This neglected tropical pathogen relies massively on membrane modulation to flourish and cause disease; these modulations range from the phagocytic mode for food acquisition to a complex trogocytosis mechanism for tissue invasion. Rab GTPases form the largest branch of the Ras-like small GTPase...
Source: Biomed Res - October 18, 2021 Category: Research Authors: Mrinalini Roy Sanket Kaushik Anupam Jyoti Vijay Kumar Srivastava Source Type: research

The Type 2 Deiodinase Thr92Ala Polymorphism Is Associated with Higher Body Mass Index and Fasting Glucose Levels: A Systematic Review and Meta-Analysis
CONCLUSION: Compared with euthyroid noncarriers (Thr/Thr), euthyroid Ala92-Dio2 carriers showed increased BMI levels, and Ala92-Dio2 carriers also had higher fasting plasma glucose levels than matched euthyroid nondiabetic noncarriers.PMID:34660805 | PMC:PMC8516525 | DOI:10.1155/2021/9914009 (Source: Biomed Res)
Source: Biomed Res - October 18, 2021 Category: Research Authors: Xichang Wang Kan Chen Chenyu Zhang Haoyu Wang Jiashu Li Chuyuan Wang Weiping Teng Zhongyan Shan Yaxin Lai Source Type: research

Development of a KRAS-Associated Metabolic Risk Model for Prognostic Prediction in Pancreatic Cancer
CONCLUSIONS: We constructed a risk model based on 6 KRAS-associated metabolic genes, which predicted patients' survival with high accuracy and reflected tumor metabolic characteristics and gemcitabine-associated chemoresistance in PC.PMID:34660806 | PMC:PMC8516536 | DOI:10.1155/2021/9949272 (Source: Biomed Res)
Source: Biomed Res - October 18, 2021 Category: Research Authors: Zuyi Ma Zhenchong Li Zuguang Ma Zixuan Zhou Hongkai Zhuang Chunsheng Liu Bowen Huang Yiping Zou Zehao Zheng LinLing Yang Yuanfeng Gong Shanzhou Huang Qi Zhou Chuanzhao Zhang Baohua Hou Source Type: research

The Efficacy and Safety of Different Dosages of Rituximab for Adults with Immune Thrombocytopenia: A Systematic Review and Meta-Analysis
Biomed Res Int. 2021 Oct 6;2021:9992086. doi: 10.1155/2021/9992086. eCollection 2021.ABSTRACTBACKGROUND: Rituximab has been frequently used as a second-line treatment for patients with immune thrombocytopenia (ITP). The optimal dose and course of rituximab are uncertain.METHODS: A comprehensive search for randomized controlled trials reporting the use of low-dose (100 mg) or standard-dose (375 mg/m2) rituximab in ITP treatment was conducted. Meta-analyses were performed on CRR (complete response rate), ORR (overall response rate), PRR (partial response rate), SRR (sustained response rate), infection rate, SB (significant b...
Source: Biomed Res - October 18, 2021 Category: Research Authors: Yu Dong Ming Yue Mengjiao Hu Source Type: research

Computational tibial bone remodeling over a population after total knee arthroplasty: A comparative study
J Biomed Mater Res B Appl Biomater. 2021 Oct 18. doi: 10.1002/jbm.b.34957. Online ahead of print.ABSTRACTPeriprosthetic bone loss is an important factor in tibial implant failure mechanisms in total knee arthroplasty (TKA). The purpose of this study was to validate computational postoperative bone response using longitudinal clinical DEXA densities. Computational remodeling outcome over a population was obtained by incorporating the strain-adaptive remodeling theory in finite element (FE) simulations of 26 different tibiae. Physiological loading conditions were applied, and bone mineral density (BMD) in three different reg...
Source: Biomed Res - October 18, 2021 Category: Research Authors: Thomas Anijs Sanne Eemers Yukihide Minoda David Wolfson Nico Verdonschot Dennis Janssen Source Type: research

A Two-Phase Mitosis Detection Approach Based on U-Shaped Network
Biomed Res Int. 2021 Oct 5;2021:1722652. doi: 10.1155/2021/1722652. eCollection 2021.ABSTRACTThis paper proposes a deep learning-based method for mitosis detection in breast histopathology images. A main problem in mitosis detection is that most of the datasets only have weak labels, i.e., only the coordinates indicating the center of the mitosis region. This makes most of the existing powerful object detection methods hardly be used in mitosis detection. Aiming at solving this problem, this paper firstly applies a CNN-based algorithm to pixelwisely segment the mitosis regions, based on which bounding boxes of mitosis are ...
Source: Biomed Res - October 15, 2021 Category: Research Authors: Wenjing Lu Source Type: research

FML/QuilA-Vaccinated Dogs Naturally Infected with < em > Leishmania infantum < /em > : Serum Cytokines, Clinicopathological Profile, and Parasitological Parameters
Biomed Res Int. 2021 Oct 5;2021:3192960. doi: 10.1155/2021/3192960. eCollection 2021.ABSTRACTDogs are the main reservoir of Leishmania infantum in endemic regions. Canine leishmaniasis, caused by L. infantum, can progress to a chronic disease resulting in death. Vaccines have been developed with a certain degree of success. The pathogenesis of this disease is not completely understood, especially in previously vaccinated dogs. We herein described clinical data, parasite load, serum levels of cytokines, and the reservoir potential in vdogs vaccinated with the fucose-mannose ligand (FML)/QuilA saponin vaccine (Leishmune&trad...
Source: Biomed Res - October 15, 2021 Category: Research Authors: Greg ório Guilherme Almeida Fernanda Morcatti Coura Jonata de Melo Barbieri Ana Carolina Junqueira Moura Fabiola de Oliveira Paes-Leme Adriane Pimenta da Costa-Val Source Type: research

COVID-19 Diagnosis from CT Images with Convolutional Neural Network Optimized by Marine Predator Optimization Algorithm
Biomed Res Int. 2021 Oct 12;2021:5122962. doi: 10.1155/2021/5122962. eCollection 2021.ABSTRACTIn recent years, almost every country in the world has struggled against the spread of Coronavirus Disease 2019. If governments and public health systems do not take action against the spread of the disease, it will have a severe impact on human life. A noteworthy technique to stop this pandemic is diagnosing COVID-19 infected patients and isolating them instantly. The present study proposes a method for the diagnosis of COVID-19 from CT images. The method is a hybrid method based on convolutional neural network which is optimized...
Source: Biomed Res - October 15, 2021 Category: Research Authors: Huaping Jia Junlong Zhao Ali Arshaghi Source Type: research

B7-H4 Expression in Precancerous Lesions of the Uterine Cervix
Biomed Res Int. 2021 Oct 5;2021:5857092. doi: 10.1155/2021/5857092. eCollection 2021.ABSTRACTOver 10% of patients diagnosed with cervical intraepithelial neoplasia (CIN) have no lesions detected in their cervical conization specimens. The purpose of this study was to determine the factors related to the absence of such lesions. We particularly sought to investigate whether the expression of B7-H4 in precancerous lesions and cancer of the uterine cervix plays a role in the presence or absence of residual lesions in conization specimens and whether this protein is associated with T cells (i.e., Foxp3+ regulatory T cells, CD4...
Source: Biomed Res - October 15, 2021 Category: Research Authors: Qianqian Zhang Liju Zong Hui Zhang Wei Xie Fan Yang Wenwen Sun Baoxia Cui Youzhong Zhang Source Type: research

A Bioinformatics Approach for the Prediction of Immunogenic Properties and Structure of the SARS-COV-2 B.1.617.1 Variant Spike Protein
CONCLUSION: Together, the in silico analysis revealed the predicted structure of partial S protein, immunogenic properties, and possible regions for S protein of SARS-CoV-2 and provides a valuable prelude for engineering the targeted vaccine or drug against B.1.617.1 variant of SARS-CoV-2.PMID:34651048 | PMC:PMC8510791 | DOI:10.1155/2021/7251119 (Source: Biomed Res)
Source: Biomed Res - October 15, 2021 Category: Research Authors: Vijay Kumar Srivastava Sanket Kaushik Gazal Bhargava Ajay Jain Juhi Saxena Anupam Jyoti Source Type: research

Neuropsychiatric Ramifications of COVID-19: Short-Chain Fatty Acid Deficiency and Disturbance of Microbiota-Gut-Brain Axis Signaling
Biomed Res Int. 2021 Oct 5;2021:7880448. doi: 10.1155/2021/7880448. eCollection 2021.ABSTRACTCOVID-19-associated neuropsychiatric complications are soaring. There is an urgent need to understand the link between COVID-19 and neuropsychiatric disorders. To that end, this article addresses the premise that SARS-CoV-2 infection results in gut dysbiosis and an altered microbiota-gut-brain (MGB) axis that in turn contributes to the neuropsychiatric ramifications of COVID-19. Altered MGB axis activity has been implicated independently as a risk of neuropsychiatric disorders. A review of the changes in gut microbiota composition ...
Source: Biomed Res - October 15, 2021 Category: Research Authors: Elizabeth M Sajdel-Sulkowska Source Type: research

Gene Expression Characteristics of Liver Tissue Reveal the Underlying Pathogenesis of Hepatocellular Carcinoma
CONCLUSIONS: Based on a series of investigations, it was found that miR-30b-5p may participate in the peroxisome signal transduction by downregulating ABCD3-mediated module 1, thereby promoting the development and progression of hepatocellular carcinoma. Our research results not only provide a theoretical basis for biologists to study hepatocellular carcinoma further but also offer new methods and new ideas for the personalized care and treatment of hepatocellular carcinoma.PMID:34651050 | PMC:PMC8506137 | DOI:10.1155/2021/9458328 (Source: Biomed Res)
Source: Biomed Res - October 15, 2021 Category: Research Authors: Congfang Guo Xiang Guo Yudong Rong Yirui Guo Li Zhang Source Type: research

Protective Mechanism of Trimetazidine in Myocardial Cells in Myocardial Infarction Rats through ERK Signaling Pathway
Biomed Res Int. 2021 Oct 5;2021:9924549. doi: 10.1155/2021/9924549. eCollection 2021.ABSTRACTOBJECTIVE: To study the protective effect of trimetazidine on myocardial cells in rats with myocardial infarction and explore its effect on ERK signaling pathway.METHODS: 40 SD rats were randomly divided into the sham operation group, model group, low-dose group, and high-dose group (intra-abdominal injection of trimetazidine 5 mg/kg and 10 mg/kg, respectively), construction of rat myocardial infarction model by coronary artery left anterior descending artery ligation. 7 days after surgery, the survival rate and cardiac function of...
Source: Biomed Res - October 15, 2021 Category: Research Authors: Zhenjun Wu Lihua Yu Xinyue Li Xuewen Li Source Type: research

Enhanced neural differentiation of human-induced pluripotent stem cells on aligned laminin-functionalized polyethersulfone nanofibers; a comparison between aligned and random fibers on neurogenesis
J Biomed Mater Res A. 2021 Oct 14. doi: 10.1002/jbm.a.37320. Online ahead of print.ABSTRACTDespite the numerous attempts in nerve tissue engineering, no ideal strategy has been translated into effective therapy for neuronal regeneration yet. Here, we designed a novel nerve regeneration scaffold combining aligned laminin-immobilized polyethersulfone (PES) nanofibers and human-induced pluripotent stem cells (hiPSCs) for transplantation strategies. Aligned and random PES nanofibers were fabricated by electrospinning method with a diameter of 95-500 nm and were then modified with covalent laminin bounding subsequent to O2 plas...
Source: Biomed Res - October 15, 2021 Category: Research Authors: Marzieh Ghollasi Delaram Poormoghadam Source Type: research

Oriented homo-epitaxial crystallization of polylactic acid displaying a biomimetic structure and improved blood compatibility
J Biomed Mater Res A. 2021 Oct 14. doi: 10.1002/jbm.a.37322. Online ahead of print.ABSTRACTEpitaxial crystallization and solid hot-drawing technology were employed to fabricate oriented homo-epitaxial crystallization of polylactic acid (PLA) with nano-topography to enhance its blood compatibility and mechanical characteristics as blood-contacting medical devices. The process involved solid hot stretching the PLA plates. A PLA nutrient solution was then used to immerse the oriented plates to dissolve some of the PLA solutes, ensuring plate integrity. Consequently, the drawing process exponentially enhanced the modulus and t...
Source: Biomed Res - October 15, 2021 Category: Research Authors: Zhengqiu Li Ting Wu Yueling Chen Xiaoyan Gao Jingbiao Ye Ying Jin Baoshu Chen Source Type: research

Mammary basal cells: Stars of the show
Biochim Biophys Acta Mol Cell Res. 2021 Oct 12:119159. doi: 10.1016/j.bbamcr.2021.119159. Online ahead of print.ABSTRACTNearly all mammals rely on lactation to support their young and to ensure the continued survival of their species. Despite its importance, relatively little is known about how milk is produced and how it is ejected from the lumen of mammary alveoli and ducts. This review focuses on the latter. We discuss how a relatively small number of basal cells, wrapping around each alveolar unit, contract to forcibly expel milk from the alveolar lumen. We consider how individual basal cells coordinate their activity,...
Source: Biomed Res - October 15, 2021 Category: Research Authors: Krystyna A Gieniec Felicity M Davis Source Type: research

A Two-Phase Mitosis Detection Approach Based on U-Shaped Network
Biomed Res Int. 2021 Oct 5;2021:1722652. doi: 10.1155/2021/1722652. eCollection 2021.ABSTRACTThis paper proposes a deep learning-based method for mitosis detection in breast histopathology images. A main problem in mitosis detection is that most of the datasets only have weak labels, i.e., only the coordinates indicating the center of the mitosis region. This makes most of the existing powerful object detection methods hardly be used in mitosis detection. Aiming at solving this problem, this paper firstly applies a CNN-based algorithm to pixelwisely segment the mitosis regions, based on which bounding boxes of mitosis are ...
Source: Biomed Res - October 15, 2021 Category: Research Authors: Wenjing Lu Source Type: research

FML/QuilA-Vaccinated Dogs Naturally Infected with < em > Leishmania infantum < /em > : Serum Cytokines, Clinicopathological Profile, and Parasitological Parameters
Biomed Res Int. 2021 Oct 5;2021:3192960. doi: 10.1155/2021/3192960. eCollection 2021.ABSTRACTDogs are the main reservoir of Leishmania infantum in endemic regions. Canine leishmaniasis, caused by L. infantum, can progress to a chronic disease resulting in death. Vaccines have been developed with a certain degree of success. The pathogenesis of this disease is not completely understood, especially in previously vaccinated dogs. We herein described clinical data, parasite load, serum levels of cytokines, and the reservoir potential in vdogs vaccinated with the fucose-mannose ligand (FML)/QuilA saponin vaccine (Leishmune&trad...
Source: Biomed Res - October 15, 2021 Category: Research Authors: Greg ório Guilherme Almeida Fernanda Morcatti Coura Jonata de Melo Barbieri Ana Carolina Junqueira Moura Fabiola de Oliveira Paes-Leme Adriane Pimenta da Costa-Val Source Type: research

COVID-19 Diagnosis from CT Images with Convolutional Neural Network Optimized by Marine Predator Optimization Algorithm
Biomed Res Int. 2021 Oct 12;2021:5122962. doi: 10.1155/2021/5122962. eCollection 2021.ABSTRACTIn recent years, almost every country in the world has struggled against the spread of Coronavirus Disease 2019. If governments and public health systems do not take action against the spread of the disease, it will have a severe impact on human life. A noteworthy technique to stop this pandemic is diagnosing COVID-19 infected patients and isolating them instantly. The present study proposes a method for the diagnosis of COVID-19 from CT images. The method is a hybrid method based on convolutional neural network which is optimized...
Source: Biomed Res - October 15, 2021 Category: Research Authors: Huaping Jia Junlong Zhao Ali Arshaghi Source Type: research

B7-H4 Expression in Precancerous Lesions of the Uterine Cervix
Biomed Res Int. 2021 Oct 5;2021:5857092. doi: 10.1155/2021/5857092. eCollection 2021.ABSTRACTOver 10% of patients diagnosed with cervical intraepithelial neoplasia (CIN) have no lesions detected in their cervical conization specimens. The purpose of this study was to determine the factors related to the absence of such lesions. We particularly sought to investigate whether the expression of B7-H4 in precancerous lesions and cancer of the uterine cervix plays a role in the presence or absence of residual lesions in conization specimens and whether this protein is associated with T cells (i.e., Foxp3+ regulatory T cells, CD4...
Source: Biomed Res - October 15, 2021 Category: Research Authors: Qianqian Zhang Liju Zong Hui Zhang Wei Xie Fan Yang Wenwen Sun Baoxia Cui Youzhong Zhang Source Type: research

A Bioinformatics Approach for the Prediction of Immunogenic Properties and Structure of the SARS-COV-2 B.1.617.1 Variant Spike Protein
CONCLUSION: Together, the in silico analysis revealed the predicted structure of partial S protein, immunogenic properties, and possible regions for S protein of SARS-CoV-2 and provides a valuable prelude for engineering the targeted vaccine or drug against B.1.617.1 variant of SARS-CoV-2.PMID:34651048 | PMC:PMC8510791 | DOI:10.1155/2021/7251119 (Source: Biomed Res)
Source: Biomed Res - October 15, 2021 Category: Research Authors: Vijay Kumar Srivastava Sanket Kaushik Gazal Bhargava Ajay Jain Juhi Saxena Anupam Jyoti Source Type: research

Neuropsychiatric Ramifications of COVID-19: Short-Chain Fatty Acid Deficiency and Disturbance of Microbiota-Gut-Brain Axis Signaling
Biomed Res Int. 2021 Oct 5;2021:7880448. doi: 10.1155/2021/7880448. eCollection 2021.ABSTRACTCOVID-19-associated neuropsychiatric complications are soaring. There is an urgent need to understand the link between COVID-19 and neuropsychiatric disorders. To that end, this article addresses the premise that SARS-CoV-2 infection results in gut dysbiosis and an altered microbiota-gut-brain (MGB) axis that in turn contributes to the neuropsychiatric ramifications of COVID-19. Altered MGB axis activity has been implicated independently as a risk of neuropsychiatric disorders. A review of the changes in gut microbiota composition ...
Source: Biomed Res - October 15, 2021 Category: Research Authors: Elizabeth M Sajdel-Sulkowska Source Type: research