Sevoflurane inhibits presynaptic calcium influx without affecting presynaptic action potentials in hippocampal CA1 region.
In this study, we examined the effect of sevoflurane on the excitatory synaptic transmission at CA1 synapses in hippocampal slices of mice. Sevoflurane at 5% was mixed with 95% O2 and 5% CO2 and bubbled in artificial cerebral spinal fluid (0.69 mM). Extracellular recordings of the field excitatory postsynaptic potential (fEPSP) and presynaptic fiber volley (FV) were made at physiological temperature. In addition, fluorescent measurements of presynaptic Ca2+ transients were performed while simultaneously recording fEPSP. Application of sevoflurane reduced the amplitude of fEPSP (45 ± 8%, n = 5). This effect was accom...
Source: Biomed Res - October 19, 2018 Category: Research Authors: Hasegawa K, Kamiya H, Morimoto Y Tags: Biomed Res Source Type: research

Gnetin C suppresses double-stranded RNA-induced C-C motif chemokine ligand 2 (CCL2) and CCL5 production by inhibiting Toll-like receptor 3 signaling pathway.
Abstract The innate immune system is a prerequisite for biophylactic ability, but its dysregulation can cause inflammatory and autoimmune diseases. To determine a safe method of controlling inflammatory reactions in the brain, we examined the effects of gnetin C, a natural resveratrol dimer, on C-C motif chemokine ligand 2 (CCL2) and CCL5 (pro-inflammatory chemokines) production observed after treatment with polyinosinic-polycytidylic acid [poly IC; a synthetic analog of dsRNA as a Toll-like receptor 3 (TRL3) ligand, 30 μg/mL] in cultured human astrocytoma U373MG and neuroblastoma SH-SY5Y cells. The addition of...
Source: Biomed Res - October 19, 2018 Category: Research Authors: Yoshida H, Imaizumi T, Matsumiya T, Seya K, Kawaguchi S, Tanaka H Tags: Biomed Res Source Type: research

Inhalation of Japanese cedar (Cryptomeria japonica) wood odor causes psychological relaxation after monotonous work among female participants.
In this study, we evaluated the effects of essential oil derived from Japanese cedar (Cryptomeria japonica) wood on the recovery state of female participants after they performed monotonous work. We determined the levels of salivary stress markers to describe the endocrinological responses. And we also used questionnaires to assess the perception of the odor of experimental rooms and psychological states. We found that olfactory stimulation with the volatile compounds of essential oil derived from Japanese cedar wood modulates mood states, and may transiently decrease sympathetic nervous activity. We suggest that olfactory...
Source: Biomed Res - October 19, 2018 Category: Research Authors: Matsubara E, Ohira T Tags: Biomed Res Source Type: research

1O, 20O-diacetyl kamebakaurin protects against acetaminophen-induced hepatotoxicity in mice.
Abstract The present study aimed to investigate the protective effects of kamebakaurin (KA) and 1O, 20O-diacetyl kamebakaurin (Ac2KA) on acetaminophen (APAP)-induced hepatotoxicity and compare the hepatoprotective mechanisms of the two chemicals. Seven-week-old male C57BL/6J mice were orally administered KA, Ac2KA, or an ethanol/olive oil emulsion once per day for 7-days. Twenty-four hours after the final administration, the mice were fasted and then intraperitoneally injected with 450 mg/kg APAP or saline. At 16 h after injection, the mice were euthanized and blood samples were collected for plasma analysis. Pret...
Source: Biomed Res - October 19, 2018 Category: Research Authors: Yoshioka H, Nonogaki T, Ohnishi H, Fukuishi N, Yoshikawa M, Gui MY, Jin YR, Li XW, Adachi Y, Ohno N, Takeya K, Hitotsuyanagi Y, Miura N, Aoyagi Y Tags: Biomed Res Source Type: research

Analgesic effects of minodronate in a rat chronic pain model.
Abstract We evaluated the analgesic effects of minodronate, alendronate and pregabalin on mechanical and thermal allodynia, as well as changes in bone mineral density and skeletal muscle volume caused by chronic constriction injury (CCI) in an ovariectomized rat. Ovariectomy was performed on four-week-old female Wistar rats. Thereafter, at 8-weeks of age, the left sciatic nerve was ligated to create the chronic pain model (CCI limb), and sham surgery was performed on the right hindlimb. In all rats, either minodronate (0.15 mg/kg/week), alendronate (0.15 mg/kg/week), pregabalin (10 mg/kg/week), or their vehicle wa...
Source: Biomed Res - October 19, 2018 Category: Research Authors: Kasukawa Y, Miyakoshi N, Suzuki M, Tsuchie H, Sato C, Kawano T, Akagawa M, Ono Y, Shimada Y Tags: Biomed Res Source Type: research

F806 Suppresses the Invasion and Metastasis of Esophageal Squamous Cell Carcinoma via Downregulating F-Actin Assembly-Related Rho Family Proteins.
Abstract Invasion and metastasis are critical pathological and mortal processes in esophageal squamous cell carcinoma (ESCC). Novel drugs, targeting the two cancer migration stages, will augment the treatment options for ESCC therapy and improve overall survival. A novel natural macrolide F806 specifically promotes apoptosis of various ESCC cells. However, whether F806 can inhibit metastasis of ESCC cells needs further evaluation. Here, our data showed that F806 inhibits dynamic F-actin assembly and then suppresses the migration of ESCC cells in vitro and their invasion and metastasis in vivo. The correlation betw...
Source: Biomed Res - October 18, 2018 Category: Research Authors: Xie L, Li LY, Zheng D, Xie YM, Xu XE, Tao LH, Liao LD, Xie YH, Cheng YW, Xu LY, Li EM Tags: Biomed Res Int Source Type: research

Effect of Post-Cam Design for Normal Knee Joint Kinematic, Ligament, and Quadriceps Force in Patient-Specific Posterior-Stabilized Total Knee Arthroplasty by Using Finite Element Analysis.
Abstract The purpose of this study is to investigate post-cam design via finite element analysis to evaluate the most normal-like knee mechanics. We developed five different three-dimensional computational models of customized posterior-stabilized (PS) total knee arthroplasty (TKA) involving identical surfaces with the exception of the post-cam geometry. They include flat-and-flat, curve-and-curve (concave), curve-and-curve (concave and convex), helical, and asymmetrical post-cam designs. We compared the kinematics, collateral ligament force, and quadriceps force in the customized PS-TKA with five different post-c...
Source: Biomed Res - October 18, 2018 Category: Research Authors: Koh YG, Son J, Kwon OR, Kwon SK, Kang KT Tags: Biomed Res Int Source Type: research

Prediction of Thin-Walled Areas of Unruptured Cerebral Aneurysms through Comparison of Normalized Hemodynamic Parameters and Intraoperative Images.
Abstract Object: Rupture of a cerebral aneurysm occurs mainly in a thin-walled area (TWA). Prediction of TWAs would help to assess the risk of rupture and select appropriate treatment strategy. There are several limitations of current prediction techniques for TWAs. To predict TWAs more accurately, HP should be normalized to minimize the influence of analysis conditions, and the effectiveness of normalized, combined hemodynamic parameters (CHPs) should be investigated with help of the quantitative color analysis of intraoperative images. Methods: A total of 21 unruptured cerebral aneurysms in 19 patients were...
Source: Biomed Res - October 18, 2018 Category: Research Authors: Cho KC, Choi JH, Oh JH, Kim YB Tags: Biomed Res Int Source Type: research

Disparities in Intimate Partner Violence among Currently Married Women from Food Secure and Insecure Urban Households in South Ethiopia: A Community Based Comparative Cross-Sectional Study.
Abstract Intimate partner violence (IPV) against women and food insecurity are an ever growing public health concerns in Ethiopia. However, the connection between the two is not yet well investigated. Therefore, this study compares IPV by household food security status and examines the association between IPV and food insecurity and among currently married women in childbearing age in Arba Minch town, South Ethiopia. A community based comparative cross-sectional study was conducted among 696 currently married women (15-49). A quantitative data was collected using a pretested and structured questionnaire on randoml...
Source: Biomed Res - October 18, 2018 Category: Research Authors: Andarge E, Shiferaw Y Tags: Biomed Res Int Source Type: research

Assessment of the Influence on Spontaneous Pregnancy of Hysterosalpingo-Contrast Sonography.
Abstract Objective: Our objective was to explore whether the pregnancy rate (PR) was higher than usual after hysterosalpingo-contrast sonography (HyCoSy). Methods: We conducted a prospective observational study of 1,008 infertility patients, all of whom were examined by HyCoSy. The expected time for spontaneous pregnancy was at least 180 days after the HyCoSy exams. There were three types of HyCoSy results: type I, defined as both fallopian tubes patent; type II, defined as one fallopian tube patent with obstruction in the other; and type III, defined as both fallopian tubes obstructed. During the HyCoSy exam...
Source: Biomed Res - October 18, 2018 Category: Research Authors: Chunyan G, Bin P, Ping Y, Yue Z, Yang X, Hongju T, Li S, Xi X Tags: Biomed Res Int Source Type: research

Performance Assessment of the Mortality in Emergency Department Sepsis Score, Modified Early Warning Score, Rapid Emergency Medicine Score, and Rapid Acute Physiology Score in Predicting Survival Outcomes of Adult Renal Abscess Patients in the Emergency Department.
Conclusion: Our study is the largest of its kind in examining ED patients with renal abscess. MEDS has been demonstrated to be superior to MEWS, REMS, and RAPS in predicting mortality for this patient population. We recommend its use for evaluation of disease severity and risk stratification in these patients, to expedite identification of critically ill patients requiring urgent intervention. PMID: 30327779 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - October 18, 2018 Category: Research Authors: Chang SH, Hsieh CH, Weng YM, Hsieh MS, Goh ZNL, Chen HY, Chang T, Ng CJ, Seak JC, Seak CK, Seak CJ Tags: Biomed Res Int Source Type: research

Screening Potential Probiotic Characteristics of Lactobacillus brevis Strains In Vitro and Intervention Effect on Type I Diabetes In Vivo.
Abstract Diabetes has become the third most serious threat to human health, after cancer and cardiovascular disease. Notably, Lactobacillus brevis is the most common species of LAB that produces γ-aminobutyric acid (GABA). The aim of this study is to clarify the effect of time, strain types, antibiotic concentrations, different levels of pH, and intestinal juices in aerobic or anaerobic conditions and the effect of interactions between these factors on the potential properties of KLDS 1.0727 and KLDS 1.0373, furthermore, antagonistic activity against foodborne pathogens. Moreover, another aim is to study the...
Source: Biomed Res - October 18, 2018 Category: Research Authors: Abdelazez A, Abdelmotaal H, Evivie SE, Melak S, Jia FF, Khoso MH, Zhu ZT, Zhang LJ, Sami R, Meng XC Tags: Biomed Res Int Source Type: research

Nonintegrating Direct Conversion Using mRNA into Hepatocyte-Like Cells.
In conclusion, our data suggest that the nonintegrating method using mRNA has potential for cell therapy. PMID: 30327781 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - October 18, 2018 Category: Research Authors: Yoon S, Kang K, Cho YD, Kim Y, Buisson EM, Yim JH, Lee SB, Ryu KY, Jeong J, Choi D Tags: Biomed Res Int Source Type: research

Polymorphisms in the Chicken Growth Differentiation Factor 9 Gene Associated with Reproductive Traits.
Abstract The aim of the study was to investigate GDF9 gene polymorphisms and their association with reproductive traits in chicken using DNA sequencing. A total of 279 Dongxiang blue-shelled (DX) chickens and 232 Luhua (LH) chickens were used for validation. We detected 15 single nucleotide polymorphisms (SNPs): nine SNPs were previously unreported in chicken, two were missense mutations, and only three exhibited significant associations with reproductive traits. G.17156387C>T was significantly associated with age at first egg (AFE) and weight of first egg (WFE) in both breeds. Birds carrying the CC genotype ex...
Source: Biomed Res - October 18, 2018 Category: Research Authors: Liu L, Cui Z, Xiao Q, Zhang H, Zhao X, Wang Y, Yin H, Li D, Zhu Q Tags: Biomed Res Int Source Type: research

How to Treat Chronic Idiopathic Testicular Pain? Scrotoscopy with a Novel Percutaneous Endoscopy Equipment.
Abstract Background: Management of chronic idiopathic testicular pain may be difficult because of problems identifying the causes. We evaluated "AUTOKLAV", a novel endourological nephrolithotomy device to diagnose and treat chronic idiopathic testicular pain. Methods: We divided 103 patients to either scrotoscopy group (SG, n = 64) or open exploration group (OEG, n = 39) between September 2014 and March 2017 at Zhongnan Hospital. Perioperative information, like operating time, length of incision, and wound infections, was carefully recorded during in hospital. Follow-up data, like pain scores improv...
Source: Biomed Res - October 18, 2018 Category: Research Authors: Lei J, Luo C, Su X, Wang X Tags: Biomed Res Int Source Type: research

Efficacy of Memantine as Adjunct Therapy for Autism Spectrum Disorder in Children Aged < 14 Years.
Efficacy of Memantine as Adjunct Therapy for Autism Spectrum Disorder in Children Aged 0.05) but post intervention, total scores of ASD symptoms in both groups of memantine (mean score1 =95.20 ± 14.49; mean score2=73.50 ± 9.81) and control group (mean scorebefore = 91.50 ± 14.35; mean scoreafter = 89.63 ± 13.95) showed a decrease which was only significant in intervention group (P
Source: Biomed Res - October 17, 2018 Category: Research Authors: Karahmadi M, Tarrahi MJ, Vatankhah Ardestani SS, Omranifard V, Farzaneh B Tags: Adv Biomed Res Source Type: research

Evaluation of the Efficiency of Ethanol Precipitation and Ultrafiltration on the Purification and Characteristics of Exopolysaccharides Produced by Three Lactic Acid Bacteria.
Abstract Exopolysaccharides (EPS) produced by three Lactic Acid Bacteria strains, Lactococcus lactis SLT10, Lactobacillus plantarum C7, and Leuconostoc mesenteroides B3, were isolated using two methods: ethanol precipitation (EPS-ETOH) and ultrafiltration (EPS-UF) through a 10 KDa cut-off membrane. EPS recovery by ultrafiltration was higher than ethanol precipitation for Lactococcus lactis SLT10 and Lactobacillus plantarum C7. However, it was similar with both methods for Leuconostoc mesenteroides B3. The monomer composition of the EPS fractions revealed differences in structures and molar ratios between the two s...
Source: Biomed Res - October 17, 2018 Category: Research Authors: Ziadi M, Bouzaiene T, M'Hir S, Zaafouri K, Mokhtar F, Hamdi M, Boisset-Helbert C Tags: Biomed Res Int Source Type: research

The Oncogenic Role of ARG1 in Progression and Metastasis of Hepatocellular Carcinoma.
In conclusion, ARG1 might play a pivotal role as an oncogene in the progression of HCC through promoting the EMT process. PMID: 30320132 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - October 17, 2018 Category: Research Authors: You J, Chen W, Chen J, Zheng Q, Dong J, Zhu Y Tags: Biomed Res Int Source Type: research

Postpartum Depression and Risk Factors among Vietnamese Women.
Abstract Postpartum depression (PPD) places a burden on maternal health. PPD exerts a negative impact on mothers' health and children's life. The purpose of this research was to identify the prevalence of PPD and the risk factors contributing to PPD. Therefore, a cross-sectional quantitative study was conducted. 116 women were categorized into two groups. One category included new mothers who received scores of Edinburgh Postpartum Depression Scale (EPDS) 12 or more. The other category included mothers who received scores less than 12. Descriptive statistic and then binary logistic regression were also performed. ...
Source: Biomed Res - October 17, 2018 Category: Research Authors: Do TKL, Nguyen TTH, Pham TTH Tags: Biomed Res Int Source Type: research

Bone Marrow-Derived Endothelial Progenitor Cells Contribute to Monocrotaline-Induced Pulmonary Arterial Hypertension in Rats via Inhibition of Store-Operated Ca2+ Channels.
Conclusions: The SOC activities were inhibited in BM-derived EPCs of MCT-treated rats. These results may be associated with the depressed expression of Orai3, TRPC1, TRPC3, and TRPC6, which are major mediators of SOC. PMID: 30320134 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - October 17, 2018 Category: Research Authors: Miao R, Wan J, Liu J, Yuan JX, Wang J, Xie W, Zhai Z, Wang C Tags: Biomed Res Int Source Type: research

Antioxidant and Tyrosinase Inhibitory Activities of Seed Oils from Torreya grandis Fort. ex Lindl.
In this study, we extracted five different seed oils, including T. grandis seed oil (TGSO), T. grandis "Xiangyafei" seed oil (XYSO), T. grandis "Zhimafei" seed oil (ZMSO), T. grandis "Majus"seed oil (TGMSO), and T. grandis "cunguangfei" seed oil (CGSO) using physical pressure. The resulting extracts were analyzed to determine their fatty acid composition, antioxidant activity, and inhibitory activity towards tyrosinase. The results of the antioxidant activity assays revealed that XYSO and ZMSO exhibited much greater DPPH radical scavenging activity and ferric reducing power than TGSO...
Source: Biomed Res - October 17, 2018 Category: Research Authors: Cui HX, Duan FF, Jia SS, Cheng FR, Yuan K Tags: Biomed Res Int Source Type: research

Effects of a Superabsorbent Resin with Boron on Bacterial Diversity of Peat Substrate and Maize Straw.
In this study, a new type of superabsorbent resin with boron (SARB) was used as a functional material mixed with peat substrate and maize straw in percentages (mass ratio) of 0.05%, 0.1%, 0.15%, and 0.2%, respectively, and high-throughput sequencing technology was used to test bacterial diversity, analyzing and exploring ecological safety of the superabsorbent resin with boron (SARB) in order to provide theoretical support for field applications. The research results show that the superabsorbent resin with boron (SARB) can promote bacterial community diversity in the maize straw. In ten treatments, Proteobacteria accounted...
Source: Biomed Res - October 17, 2018 Category: Research Authors: Wang Y, Wang C, Zhao Y, Wang P Tags: Biomed Res Int Source Type: research

Adiponectin and Omentin Levels as Predictive Biomarkers of Preterm Birth in Patients with Gestational Diabetes Mellitus.
Abstract Objective: The aim of this study was to determine any changes in adiponectin and omentin levels in GDM patients who delivered at term and preterm and to evaluate whether adipokines can be useful as a clinical biomarker to predict subsequent preterm delivery. Patients and Methods: The levels of adiponectin and omentin were measured in four groups: (1) women with GDM who delivered at term (n=63); (2) women with GDM who had the symptoms of threatened preterm labor and delivered at term (n=23); (3) women with GDM and spontaneous preterm birth (before 37 completed weeks of gestation) (n=19); (4) women wit...
Source: Biomed Res - October 17, 2018 Category: Research Authors: Mierzyński R, Dłuski D, Nowakowski Ł, Poniedziałek-Czajkowska E, Leszczyńska-Gorzelak B Tags: Biomed Res Int Source Type: research

Benefit of Contact Force Sensing Catheter Technology for Successful Left Atrial Anterior Line Formation: A Prospective Randomized Trial.
Conclusion: Information on contact force does not significantly improve the ablation of LA anterior lines. Clinical Trial Registration: The trial was registered at http://www.clinicaltrials.gov by identifier: NCT02217657. PMID: 30320138 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - October 17, 2018 Category: Research Authors: Fichtner S, Wakili R, Rizas K, Siebermair J, Sinner MF, Wiktor T, Lackermair K, Schuessler F, Olesch L, Rainer S, Kääb S, Curta A, Kramer H, Estner HL Tags: Biomed Res Int Source Type: research

Effect of oxidation on intrinsic residual stress in amorphous silicon carbide films.
Abstract The change in residual stress in plasma enhanced chemical vapor deposition amorphous silicon carbide (a-SiC:H) films exposed to air and wet ambient environments is investigated. A close relationship between stress change and deposition condition is identified from mechanical and chemical characterization of a-SiC:H films. Evidence of amorphous silicon carbide films reacting with oxygen and water vapor in the ambient environment are presented. The effect of deposition parameters on oxidation and stress variation in a-SiC:H film is studied. It is found that the films deposited at low temperature or power ar...
Source: Biomed Res - October 15, 2018 Category: Research Authors: Deku F, Mohammed S, Joshi-Imre A, Maeng J, Danda V, Gardner TJ, Cogan SF Tags: J Biomed Mater Res B Appl Biomater Source Type: research

Preparation and Evaluation of Lipid-Based Liquid Crystalline Formulation of Fenofibrate.
Conclusions: In the most formulations of FFB LCs, the DE% was more than the pure drug, and therefore, it seems that the liquid crystalline formulations can be effective for enhancing drug release. Furthermore, drug release rate depended on the stabilizer type so that the presence of colloidal silica caused slower drug release compared to Pluronic F127. PMID: 30310774 [PubMed] (Source: Biomed Res)
Source: Biomed Res - October 14, 2018 Category: Research Authors: Kazemi M, Varshosaz J, Tabbakhian M Tags: Adv Biomed Res Source Type: research

The Relationship between Dietary Patterns with Blood Pressure in Iranian Army Staffs.
Conclusion: Our findings indicated that dietary patterns did not have any significant relationship with SBP and DBP after adjustment for confounders in the healthy military. To identify the dietary patterns associated with BP in healthy military, more strong design studies and more participants should be conducted in the future. PMID: 30310775 [PubMed] (Source: Biomed Res)
Source: Biomed Res - October 14, 2018 Category: Research Authors: Dabbagh-Moghaddam A, Kamali M, Hojjati A, Foroughi M, Ghiasvand R, Askari G, Hosseinzadeh J Tags: Adv Biomed Res Source Type: research

SOFT Syndrome: The First Case in Iran.
Abstract Primordial dwarfism (PD) is a group of rare genetically heterogeneous disorders consisted of disorders with intrauterine growth retardation continued through the life. SOFT syndrome with characteristics of short stature, onychodysplasia, facial dysmorphism, and hypotrichosis has been presented as a subtype of PD. Only 20 cases of SOFT syndrome have been reported in world to date, but none of them were not in Iran. Our case was 6.5-year-old girl with a complaint of growth retardation including height of 97 cm (Z = -4.6 standard deviation [SD]) and weight of 14 kg (Z = -4 SD) referred to growth clinic. She ...
Source: Biomed Res - October 14, 2018 Category: Research Authors: Mostofizadeh N, Gheidarloo M, Hashemipour M, Dehkordi EH Tags: Adv Biomed Res Source Type: research

Retraction: The Role of Stem Cell Therapy in Multiple Sclerosis: An Overview of the Current Status of the Clinical Studies.
Authors: Abstract [This retracts the article on p. 46 in vol. 5, PMID: 27110543.]. PMID: 30310777 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - October 14, 2018 Category: Research Tags: Adv Biomed Res Source Type: research

Erratum: A Randomized Double-blind Placebo-controlled Trial to Assess the Effect of Tamarind seed in Premature Ejaculation.
Authors: Abstract [This corrects the article on p. 59 in vol. 7, PMID: 29862208.]. PMID: 30310778 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - October 14, 2018 Category: Research Tags: Adv Biomed Res Source Type: research

Omalizumab for Severe Asthma: Beyond Allergic Asthma.
Abstract Different subsets of asthma patients may be recognized according to the exposure trigger and the frequency and severity of clinical signs and symptoms. Regarding the exposure trigger, generally asthma can be classified as allergic (or atopic) and nonallergic (or nonatopic). Allergic and nonallergic asthma are distinguished by the presence or absence of clinical allergic reaction and in vitro IgE response to specific aeroallergens. The mechanisms of allergic asthma have been extensively studied with major advances in the last two decades. Nonallergic asthma is characterized by its apparent independence fro...
Source: Biomed Res - October 14, 2018 Category: Research Authors: Loureiro CC, Amaral L, Ferreira JA, Lima R, Pardal C, Fernandes I, Semedo L, Arrobas A Tags: Biomed Res Int Source Type: research

Impact and Lessons Learned from a National Consortium for Participatory Health Research: PartKommPlus-German Research Consortium for Healthy Communities (2015-2018).
Abstract Integrated strategies of health promotion at the municipal level are receiving particular attention in public health policy and practice in Germany. These strategies are intended to provide a coordinated approach to health promotion during the entire lifespan, with a particular focus on vulnerable communities. They are also intended to be participatory in both their design and implementation, involving all sectors of the social welfare, educational and healthcare systems, civil society, and the general public. PartKommPlus-German Research Consortium for Healthy Communities is examining such strategies usi...
Source: Biomed Res - October 14, 2018 Category: Research Authors: Wright MT, Hartung S, Bach M, Brandes S, Gebhardt B, Jordan S, Schaefer I, Wihofszky P Tags: Biomed Res Int Source Type: research

VEGFR2 Expression Is Differently Modulated by Parity and Nulliparity in Mouse Ovary.
This study is aimed at determining if ovarian VEGF and VEGFR2 expression are differently modulated in the ovaries of parous and nulliparous mice. To this end primiparous and nulliparous fertile mice were sacrificed at postovulatory stage. Whole ovaries, corpus luteum, and residual stromal tissues were analyzed to assess VEGF/VEGFR2 expression levels. Ovarian mRNA amounts of Vegfa (120 and 164) and Vegfr2 were comparable between primiparous and nulliparous mice; both isoforms and receptor were accumulated mainly in corpus luteum tissues. VEGF 120 and 164 protein accumulation and distribution mirrored that of mRNA. Conversel...
Source: Biomed Res - October 14, 2018 Category: Research Authors: Di Nisio V, Rossi G, Iorio R, Pellegrini C, Macchiarelli G, Tiboni GM, Petricca S, Cecconi S Tags: Biomed Res Int Source Type: research

In Vitro Antibacterial Activity of Propyl-Propane-Thiosulfinate and Propyl-Propane-Thiosulfonate Derived from Allium spp. against Gram-Negative and Gram-Positive Multidrug-Resistant Bacteria Isolated from Human Samples.
Conclusion: PTS and PTSO have a significant broad spectrum antibacterial activity against multiresistant bacteria isolated from human clinical samples. Preliminary results in present work provide basic and useful information for development and potential use of these compounds in the treatment of human infections. PMID: 30310819 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - October 14, 2018 Category: Research Authors: Sorlozano-Puerto A, Albertuz-Crespo M, Lopez-Machado I, Ariza-Romero JJ, Baños-Arjona A, Exposito-Ruiz M, Gutierrez-Fernandez J Tags: Biomed Res Int Source Type: research

Association of p16 as Prognostic Factors for Oropharyngeal Cancer: Evaluation of p16 in 1470 Patients for a 16 Year Study in Northeast China.
Abstract Human papillomavirus (HPV) is an etiological risk factor for oropharyngeal squamous cell carcinomas (OPSCC). Our study investigates the prevalence, prognostic, and clinicopathologic features of HPV-related oropharyngeal cancer in Northeast China and elucidates the involvement of p16 in the tumorigenesis and progression of OPSCC. Specimens from 1470 OPSCC patients collected from 2000 to 2016 were analyzed using the status of HPV by polymerase chain reaction (PCR) and p16 immunohistochemistry. Overexpression of p16 was observed in 81 (5.51%) of the 1470 cases, and HPV positive was present in 78 cases (5.31%...
Source: Biomed Res - October 14, 2018 Category: Research Authors: Meng HX, Miao SS, Chen K, Li HN, Yao G, Geng J, Wang H, Shi QT, He J, Mao X, Tong FJ, Wei LL, Sun J, Tan D, You Q, Li X, Geng JS Tags: Biomed Res Int Source Type: research

Treatment of Punctate Inner Choroidopathy with Choroidal Neovascularization Using Corticosteroid and Intravitreal Ranibizumab.
Conclusion: Both corticosteroid-ranibizumab treatment and ranibizumab monotherapy could significantly improve the vision of PIC patients with CNV. Combined corticosteroid and intravitreal ranibizumab treatment appeared to reduce CNV recurrence and development of new PIC lesions compared with ranibizumab monotherapy. PMID: 30302336 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - October 12, 2018 Category: Research Authors: Wu W, Li S, Xu H, Liu Y, Wang Y, Lai TYY, Yin ZQ Tags: Biomed Res Int Source Type: research

Global Trends in Application of Stereology as a Quantitative Tool in Biomedical Research.
Abstract Stereology is a quantitative and comparative method that utilizes planes, lines, and points for the estimation of three-dimensional parameters in morphological studies. It primarily focuses on geometrical features of objects such as number, density, length, area, and volume. A scientometric study was conducted to analyze global research trends in application of stereology in biomedical research. Stereology has gained wide application resulting into design-based stereological methods. Data for this study were retrieved from the SCOPUS database. At least 5,732 publications employing stereology as analytical...
Source: Biomed Res - October 12, 2018 Category: Research Authors: Kipanyula MJ, Sife AS Tags: Biomed Res Int Source Type: research

Social Cognition through the Lens of Cognitive and Clinical Neuroscience.
Abstract Social cognition refers to a set of processes, ranging from perception to decision-making, underlying the ability to decode others' intentions and behaviors to plan actions fitting with social and moral, besides individual and economic considerations. Its centrality in everyday life reflects the neural complexity of social processing and the ubiquity of social cognitive deficits in different pathological conditions. Social cognitive processes can be clustered in three domains associated with (a) perceptual processing of social information such as faces and emotional expressions (social perception), (b) gr...
Source: Biomed Res - October 12, 2018 Category: Research Authors: Arioli M, Crespi C, Canessa N Tags: Biomed Res Int Source Type: research

Mummification in Korea and China: Mawangdui, Song, Ming and Joseon Dynasty Mummies.
In this report, similarities and differences in the mummification processes and funerary rituals in Korea and China are highlighted. Although the historical periods, the region of excavation, and the structures of the graves differ, the cultural aspects, the mechanisms of mummification, and biological evidence appear to be essentially similar to each other. Independently from the way they are called locally, the Korean and Chinese mummies belong to the same group with a shared cultural background. PMID: 30302339 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - October 12, 2018 Category: Research Authors: Shin DH, Bianucci R, Fujita H, Hong JH Tags: Biomed Res Int Source Type: research

Endowing iPSC-Derived MSCs with Angiogenic and Keratinogenic Differentiation Potential: A Promising Cell Source for Skin Tissue Engineering.
Abstract Induced pluripotent stem cells (iPSC) hold tremendous potential for personalized cell-based therapy for skin regeneration. Aiming to establish human iPSCs as a potential cell source for skin tissue engineering, we expect to obtain an epidermal-like cell line with angiogenic and keratinogenic differentiation potential via inducing iPSC-derived mesenchymal stem cells (iPSC-MSCs) with basic fibroblast growth factor (bFGF) and/or keratinocyte growth factor (KGF). The results show that iPSC-MSCs were successfully induced with a positive FGFR/KGFR expression on the cell surface. BFGF/KGF induction could signifi...
Source: Biomed Res - October 12, 2018 Category: Research Authors: Lin W, Chen M, Hu C, Qin S, Chu C, Xiang L, Man Y, Qu Y Tags: Biomed Res Int Source Type: research

Protocol for Fecal Microbiota Transplantation in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis.
Conclusion: FMT is an effective and safe therapy for both paediatric and adult IBD; fresh or frozen donor stool, delivery route, and antibiotic pretreatment or not have no impact on the efficacy of FMT in IBD. FMT might be a potential rescue therapy and even an initial standardized therapy for IBD. However, few data exist on long-term safety and efficacy and further validation is needed. PMID: 30302341 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - October 12, 2018 Category: Research Authors: Fang H, Fu L, Wang J Tags: Biomed Res Int Source Type: research

Frailty and Exercise Training: How to Provide Best Care after Cardiac Surgery or Intervention for Elder Patients with Valvular Heart Disease.
Abstract The aim of this literature review was to evaluate existing evidence on exercise-based cardiac rehabilitation (CR) as a treatment option for elderly frail patients with valvular heart disease (VHD). Pubmed database was searched for articles between 1980 and January 2018. From 2623 articles screened, 61 on frailty and VHD and 12 on exercise-based training for patients with VHD were included in the analysis. We studied and described frailty assessment in this patient population. Studies reporting results of exercise training in patients after surgical/interventional VHD treatment were analyzed regarding cont...
Source: Biomed Res - October 12, 2018 Category: Research Authors: Tamuleviciute-Prasciene E, Drulyte K, Jurenaite G, Kubilius R, Bjarnason-Wehrens B Tags: Biomed Res Int Source Type: research

Effect of MDP-Based Primers on the Luting Agent Bond to Y-TZP Ceramic and to Dentin.
Abstract Purpose: The aim of this study was to evaluate the influence of multimode MDP-based primers and different application protocols on the bond strength of a representative resin cement to an yttrium stabilized tetragonal zirconia (Y-TZP) ceramic. Materials and Methods: The occlusal dentin from 60 human molars was exposed. The teeth and zirconia cylinders (N = 60) (3 mm of diameter; 4 mm of height) were divided into six groups (n = 10) according to the ceramic surface conditioning: (1) air abraded with SiO2 particles; (2) Z-Prime Plus; (3) air abraded with SiO2 particles + Z-Prime Plus; (4) air abraded w...
Source: Biomed Res - October 12, 2018 Category: Research Authors: Butler S, Linke B, Torrealba Y Tags: Biomed Res Int Source Type: research

The Dental Management of Patients at Risk of Medication-Related Osteonecrosis of the Jaw: New Paradigm of Primary Prevention.
Abstract Medication-related osteonecrosis of the jaw (MRONJ) is a serious adverse reaction of antiresorptive and antiangiogenic agents; it is a potentially painful and debilitating condition that can considerably affect the quality of life of patients. Furthermore, even if its epidemiology and pathogenesis have still not been fully clarified, several risk factors related to MRONJ have been recognized in prevention protocols. Three main risk factors are as follows: (i) the type of ONJ-related medications: antiresorptive (e.g., Bisphosphonates, Denosumab) and antiangiogenic drugs (e.g., Bevacizumab, Sunitinib); (ii)...
Source: Biomed Res - October 12, 2018 Category: Research Authors: Di Fede O, Panzarella V, Mauceri R, Fusco V, Bedogni A, Lo Muzio L, Sipmo Onj Board, Campisi G Tags: Biomed Res Int Source Type: research

The Augment of the Stability in Locking Compression Plate with Intramedullary Fibular Allograft for Proximal Humerus Fractures in Elderly People.
The objective of this study was to compare the clinical outcomes and complications between the locking compression plate (LCP) and LCP with fibular allograft in the treatment of patients with displaced proximal humerus fracture (PHF) in elderly people. Material and Methods: Between January 2010 and December 2013, a total of 97 elderly patients with displaced PHF were treated by LCP or LCP with fibular allograft, and finally 89 patients were included in our study. All the patients were divided into Group I (patients treated by LCP) and Group II (patients treated by LCP with fibular allograft). Function results were ass...
Source: Biomed Res - October 12, 2018 Category: Research Authors: Chen H, Yin P, Wang S, Li J, Zhang L, Khan K, Zhang L, Tang P Tags: Biomed Res Int Source Type: research

Comment on "Optic Nerve Sheath Diameter Ultrasound Evaluation in Intensive Care Unit: Possible Role and Clinical Aspects in Neurological Critical Patients' Daily Monitoring".
Comment on "Optic Nerve Sheath Diameter Ultrasound Evaluation in Intensive Care Unit: Possible Role and Clinical Aspects in Neurological Critical Patients' Daily Monitoring". Biomed Res Int. 2018;2018:6154357 Authors: De Bernardo M, Rosa N PMID: 30306088 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - October 12, 2018 Category: Research Authors: De Bernardo M, Rosa N Tags: Biomed Res Int Source Type: research

Prognostic Value and Therapeutic Perspectives of Coronary CT Angiography: A Literature Review.
one G Abstract Coronary stenosis severity is both a powerful and a still debated predictor of prognosis in coronary artery disease. Coronary computed tomographic angiography (CCTA) has emerged as a noninvasive technique that enables anatomic visualization of coronary artery disease (CAD). CCTA with newer applications, plaque characterization and physiologic/functional evaluation, allows a comprehensive diagnostic and prognostic assessment of otherwise low-intermediate subjects for primary prevention. CCTA measures the overall plaque burden, differentiates plaque subtypes, and identifies high-risk plaque with good ...
Source: Biomed Res - October 12, 2018 Category: Research Authors: Carità P, Guaricci AI, Muscogiuri G, Carrabba N, Pontone G Tags: Biomed Res Int Source Type: research

Multicriteria Decision Model and Thermal Pretreatment of Hotel Food Waste for Robust Output to Biogas: Case Study from City of Jaipur, India.
Abstract The anaerobic batch test (45 days at 37°C) was performed to describe the effect of thermal pretreatment at moderate temperatures (60, 80, and 100°C) over durations of 10 and 20 minutes on the enhancement of biogas production using hotel food waste from city of Jaipur, India. The results showed that the total cumulative biogas production with thermal pretreatment (100°C, 10 minutes) was 41% higher than the control. Also, this alternative gets first rank using multicriteria decision making model, VIKOR. This outcome was obtained due to the enhancement of degradation of organic compounds such as ...
Source: Biomed Res - October 12, 2018 Category: Research Authors: Gandhi P, Paritosh K, Pareek N, Mathur S, Lizasoain J, Gronauer A, Bauer A, Vivekanand V Tags: Biomed Res Int Source Type: research

Microbubble-Mediated Ultrasound Outweighs Low-Intensity Pulsed Ultrasound on Osteogenesis and Neovascularization in a Rabbit Model of Steroid-Associated Osteonecrosis.
This study compared the effect of this novel microbubble-mediated ultrasound (MUS) with that of the traditional LIPUS on osteogenesis and neovascularization in a rabbit model of steroid-associated osteonecrosis. We hypothesized that MUS might outweigh LIPUS on promoting osteogenesis and neovascularization in steroid-associated osteonecrosis. The bilateral femoral head necrosis was induced by lipopolysaccharide and methylprednisolone in the rabbits. The indices of bone mineral density (BMD), trabecular number, maximal loading strength, and mineral apposition rate were analyzed, demonstrating that the animal model of steroid...
Source: Biomed Res - October 11, 2018 Category: Research Authors: Xu DF, Qu GX, Yan SG, Cai XZ Tags: Biomed Res Int Source Type: research

The Antimicrobial Peptide Nal-P-113 Exerts a Reparative Effect by Promoting Cell Proliferation, Migration, and Cell Cycle Progression.
Abstract Objective: The primary purpose of this study was to evaluate the reparative efficacy of a novel antimicrobial peptide, Nal-P-113, in shortening the healing time of oral mucosal ulcers by promoting cell proliferation and migration and accelerating the cell cycle. Methods: Cell counting kit-8 (CCK-8) and wound-healing assays were used to evaluate the proliferation and migration of human immortalized oral epithelial cells (HIOECs). The cell cycle distribution of HIOECs was analyzed by flow cytometry. Additionally, the RNA levels of EGF, FGF-2, and TGF-β1 of HIOECs were assessed by real-time PCR. Ra...
Source: Biomed Res - October 11, 2018 Category: Research Authors: Liu N, Guan S, Wang H, Li C, Cheng J, Yu H, Lin L, Pan Y Tags: Biomed Res Int Source Type: research