Identification of m6A-Related lncRNA to Predict the Prognosis of Patients with Hepatocellular Carcinoma
Biomed Res Int. 2022 May 9;2022:4169150. doi: 10.1155/2022/4169150. eCollection 2022.ABSTRACTHepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide. In the past decades, HCC treatment has achieved great progress; however, the overall prognosis remains poor. Therefore, it is the need of the hour to identify new prognostic biomarkers which can advance our understanding related to the underlying molecular mechanism of adverse prognosis and apply them to clinical work in prognosis prediction. In the present study, data of 576 HCC patients and 292 normal control cases from TCGA and ICGC data...
Source: Biomed Res - May 20, 2022 Category: Research Authors: Hao Yang Hong Yang Wei Zhang Juping Wang Liping Sun Juan Gao Haiping Zhao Zhenfei Wang Source Type: research

A Novel TNFSF-Based Signature Predicts the Prognosis and Immunosuppressive Status of Lower-Grade Glioma
CONCLUSION: Our signature could accurately predict the prognosis of lower-grade gliomas (LGG). In addition, this six-gene signature could predict the immunosuppressive status of LGG and provide evidence that TNF superfamilies had correlations with some critical mutations that could be effectively targeted now.PMID:35592520 | PMC:PMC9112166 | DOI:10.1155/2022/3194996 (Source: Biomed Res)
Source: Biomed Res - May 20, 2022 Category: Research Authors: Rui Tao Qi Liu Ruoyu Huang Kuanyu Wang Zhiyan Sun Pei Yang Jiangfei Wang Source Type: research

Work-Related Musculoskeletal Disorders and Their Associated Risk Factors among Pakistani Dental Practitioners: A Cross-Sectional Study
CONCLUSION: Considering the high prevalence of WMSDs among dentists, preventive strategies that minimize the occurrence of WMSDs should be adopted by dental professionals. The impact of WMSDs can be reduced by maintaining good posture, taking breaks and rest in between work, doing regular exercise, and improving the work environment.PMID:35592521 | PMC:PMC9113859 | DOI:10.1155/2022/4099071 (Source: Biomed Res)
Source: Biomed Res - May 20, 2022 Category: Research Authors: Usman Younis Asma Shakoor Farooq Ahmad Chaudhary Shahab Ud Din Sadia Sajjad Maryiam Younis Muhammad Qasim Javed Mohammad Khursheed Alam Source Type: research

Dental Calculi of Siberian Natives, Russian Settlers, and Korean People of Joseon Dynasty Period in the 16th to 19th Century Eurasia Continent
CONCLUSION: Current study demonstrated a significant difference of calculus formation between those groups with different diets or subsistence strategies. Higher prevalence of dental calculus was observed in agriculturalist Joseon Koreans and Russian settlers, but Siberian natives exhibited relatively lower frequency of dental calculus. The results of this study enable us to reconsider the meaning of association between subsistence strategy and calculus in different historical populations.PMID:35592522 | PMC:PMC9112181 | DOI:10.1155/2022/5765604 (Source: Biomed Res)
Source: Biomed Res - May 20, 2022 Category: Research Authors: Hyejin Lee Jong Ha Hong Larisa Tataurova Sergey Slepchenko Jieun Kim Dong Hoon Shin Source Type: research

Antimicrobial Action, Genotoxicity, and Morphological Analysis of Three Calcium Silicate-Based Cements
This study is aimed at evaluating five mineral oxides (5MO), mineral trioxide aggregate repair high plasticity (MTA HP), and mineral trioxide aggregate (MTA) in relation to the antimicrobial action over Porphyromonas gingivalis, Porphyromonas endodontalis, Parvimonas micra, Fusobacterium nucleatum, and Prevotella intermedia; the genotoxicity over mouse macrophage (RAW 264.7) and osteoblast (Mg-63) cultures; and the morphological analysis using scanning electron microscopy (SEM) analysis (50 k and ×100 k). Sodium hypochlorite (NaOCl), calcium hydroxide, and saline solution were used as control groups in the different analy...
Source: Biomed Res - May 20, 2022 Category: Research Authors: Amjad Abu Hasna Ana Luisa Theodoro Larissa Marques Pereira Lucas de Paula Ramos Tiago Moreira Bastos Campos Maisour Ala Rachi Talal Al-Nahalwi Luciane Dias de Oliveira Cl áudio Antonio Talge Carvalho Source Type: research

Integrated Analysis of Multiple Microarray Studies to Identify Core Gene-Expression Signatures Involved in Tubulointerstitial Injury in Diabetic Nephropathy
Biomed Res Int. 2022 May 10;2022:9554658. doi: 10.1155/2022/9554658. eCollection 2022.ABSTRACTDiabetic nephropathy is a leading cause of end-stage renal disease in both developed and developing countries. It is lack of specific diagnosis, and the pathogenesis remains unclarified in diabetic nephropathy, following the unsatisfactory effects of existing treatments. Therefore, it is very meaningful to find biomarkers with high specificity and potential targets. Two datasets, GSE30529 and GSE47184 from GEO based on diabetic nephropathy tubular samples, were downloaded and merged after batch effect removal. A total of 545 diffe...
Source: Biomed Res - May 20, 2022 Category: Research Authors: Huandi Zhou Zhifen Yang Lin Mu Yonghong Shi Source Type: research

Epidemiology of COVID-19 in Tehran, Iran: A Cohort Study of Clinical Profile, Risk Factors, and Outcomes
CONCLUSIONS: Accurate detection of predictors of poor outcomes helps healthcare providers in stratifying patients, based on their risk factors and healthcare requirements to improve their survival chance.PMID:35592525 | PMC:PMC9113873 | DOI:10.1155/2022/2350063 (Source: Biomed Res)
Source: Biomed Res - May 20, 2022 Category: Research Authors: Hamidreza Hatamabadi Tahereh Sabaghian Amir Sadeghi Kamran Heidari Seyed Amir Ahmad Safavi-Naini Mehdi Azizmohammad Looha Nazanin Taraghikhah Shayesteh Khalili Keivan Karrabi Afsaneh Saffarian Saba Shahsavan Hossein Majlesi Amirreza Allahgholipour Komleh Source Type: research

Antioxidant Effects of Curcumin Gel in Experimental Induced Diabetes and Periodontitis in Rats
This study aimed to evaluate the effect of curcumin gel on antioxidant marker level in experimental induced diabetes and periodontitis (EDP) in rats. Adult Wistar rats were randomized into five groups (20 each): (1) EDP treated with scaling and root planing (SRP) + curcumin gel (CU), (2) EDP treated with CU, (3) EDP treated with SRP, (4) EDP without treatment, and (5) systemically healthy and without ligature (control). Each group was subdivided equally into 4 subgroups of 5 rats. Diabetes was induced by intraperitoneal injection of streptozotocin (STZ), and periodontitis was induced by a ligature. Blood samples were colle...
Source: Biomed Res - May 20, 2022 Category: Research Authors: Chenar Anwar Mohammad Khadeeja Mohammed Ali Aram Mohammed Sha Sarhang Sarwat Gul Source Type: research

Thymol Reduces < em > agr < /em > -Mediated Virulence Factor Phenol-Soluble Modulin Production in < em > Staphylococcus aureus < /em >
Biomed Res Int. 2022 May 9;2022:8221622. doi: 10.1155/2022/8221622. eCollection 2022.ABSTRACTStaphylococcus aureus is a major human bacterial pathogen that carries a large number of virulence factors. Many virulence factors of S. aureus are regulated by the accessory gene regulator (agr) quorum-sensing system. Phenol-soluble modulins (PSMs) are one of the agr-mediated virulence determinants known to play a significant role in S. aureus pathogenesis. In the present study, the efficacy of thymol to inhibit PSM production including δ-toxin in S. aureus was explored. We employed liquid chromatography-mass spectrometry (LC-MS)...
Source: Biomed Res - May 19, 2022 Category: Research Authors: Harshad Lade Sung Hee Chung Yeonhee Lee Bajarang Vasant Kumbhar Hwang-Soo Joo Yun-Gon Kim Yung-Hun Yang Jae-Seok Kim Source Type: research

Effective-Component Compatibility of Bufei Yishen Formula III Combined with Electroacupuncture Suppresses Inflammatory Response in Rats with Chronic Obstructive Pulmonary Disease via Regulating SIRT1/NF- < em > κ < /em > B Signaling
CONCLUSIONS: ECC-BYF III, electroacupuncture, and their combination can suppress inflammation, among which the combination therapy has been proven to be the most effective treatment, and the mechanism may be involved in activating SIRT1/NF-κB signaling.PMID:35586807 | PMC:PMC9110177 | DOI:10.1155/2022/3360771 (Source: Biomed Res)
Source: Biomed Res - May 19, 2022 Category: Research Authors: Fanli Jin Lanxi Zhang Kai Chen Yufang Miao Yang Liu Yange Tian Jiansheng Li Source Type: research

Design, Synthesis and Activity Study of Pyridine Derivatives as Highly Effective and Selective TYK2 Inhibitors
Biomed Res Int. 2022 May 9;2022:6383893. doi: 10.1155/2022/6383893. eCollection 2022.ABSTRACTDue to the high homology of the ATP sites of the JAK family, the development of selective inhibitors for a certain JAK isoform is extremely challenging. Our strategy to achieve high selectivity for TYK2 relies on targeting the TYK2 pseudokinase (JH2) domain. Based on the clinical compound BMS-986165, through structure-activity relationship studies, a class of acyl compounds with excellent TYK2 inhibitory activity and selectivity to other subtypes of the JAK family was discovered.PMID:35586808 | PMC:PMC9110192 | DOI:10.1155/2022/638...
Source: Biomed Res - May 19, 2022 Category: Research Authors: Chaoying Cheng Mengguang Zhou Panpan Zhang Wenjian Qian Lei Chen Guorong Chen Source Type: research

Inhibitory Effect of Lotus Leaf-Enriched Flavonoid Extract on the Growth of HT-29 Colon Cancer Cells through the Expression of PI3K-Related Molecules
CONCLUSION: Lotus leaves contain functional flavonoids that inhibit the proliferation of HT-29 colon cancer cells and regulate the expression of PI3K/Akt through five important chemicals.PMID:35586809 | PMC:PMC9110183 | DOI:10.1155/2022/6770135 (Source: Biomed Res)
Source: Biomed Res - May 19, 2022 Category: Research Authors: Chong Li Zhanming Zhou Xingyao Long Yanni Pan Rui Wang Xiufeng Chen Xin Zhao Source Type: research

Effect of Early Electroacupuncture Combined with Enhanced Recovery after Surgery (ERAS) on Pain Perception and Dysfunction in Patients after Total Knee Arthroplasty (TKA)
CONCLUSION: Early electroacupuncture combined with ERAS is of positive significance to the patients after TKA, which can reduce the pain, enhance the function of the knee joint, and promote the ROM of the knee joint, and can effectively shorten the first time out of bed and postoperative rehabilitation time and reduce whole blood viscosity low shear, plasma viscosity, and fibrinogen level, but the overall rehabilitation cost is high, and clinical application should be combined with the actual situation of patients.PMID:35586810 | PMC:PMC9110174 | DOI:10.1155/2022/6560816 (Source: Biomed Res)
Source: Biomed Res - May 19, 2022 Category: Research Authors: Tian Zhang Hongju Liu Hui Li Sha He Li Xiao Ting Qin Wei Long Xu Source Type: research

SNORD15B and SNORA5C: Novel Diagnostic and Prognostic Biomarkers for Colorectal Cancer
This study confirms that SNORD15B and SNORA5C have oncogenic effects in carcinogenesis of CRC. The findings suggest the two genes as potential diagnostic and prognostic biomarkers for CRC.PMID:35586811 | PMC:PMC9110153 | DOI:10.1155/2022/8260800 (Source: Biomed Res)
Source: Biomed Res - May 19, 2022 Category: Research Authors: Liping Shen Wenqing Lu Yujv Huang Junyan He Qi Wang Xiaofei Zheng Zhidong Wang Source Type: research

Exploration of the Potential Mechanism of the Common Differentially Expressed Genes in Psoriasis and Atopic Dermatitis
CONCLUSION: We constructed the predicted PPI networks and functional modules related to psoriasis and atopic dermatitis and distinguished the key candidate target genes CXCL8, STAT1, and MMP9 in the diagnosis and therapy of similar pathogenesis.PMID:35586812 | PMC:PMC9110199 | DOI:10.1155/2022/1177299 (Source: Biomed Res)
Source: Biomed Res - May 19, 2022 Category: Research Authors: Zhiyu Zhou Li Meng Yawen Cai Wannian Yan Yun Bai Jia Chen Source Type: research