3D magnetic nanocomposite scaffolds enhanced the osteogenic capacities of rat bone mesenchymal stem cells in vitro and in a rat calvarial bone defect model by promoting cell adhesion
In this study, 3D-printed poly(lactic-co-glycolic acid) scaffolds were coated with IONPs using layer-by-layer assembly (Fe-scaffold) to prepare magnetic scaffolds. The effects of this modification on osteogenesis were investigated by comparison with untreated scaffolds (Uncoated-scaffold). The results showed that the proliferation of rat bone mesenchymal stem cells (rBMSCs) on the Fe-scaffold was enhanced compared with those on the Uncoated-scaffold (p
Source: Biomed Res - April 20, 2021 Category: Research Authors: Liping Han Yu Guo Lu Jia Qian Zhang Liuxu Sun Zukun Yang Yang Dai Zhichao Lou Yang Xia Source Type: research

Effect of Root Canal Filling Materials and Pretreatment with Solvents on the Shear Bond Strength of Composite Resin with Primary Tooth Dentin
This study was aimed at evaluating the effect of root canal filling materials and their solvents on the shear bond strength (SBS) of resin composite with the primary tooth dentin.METHODS AND MATERIALS: Seventy-two intact anterior primary teeth were selected. Smooth dentinal surfaces were prepared to a minimum diameter of 3 mm and thickness of 1.5-2.0 mm. The samples were equally divided into six groups (n = 12). In group 1: control group, no root filling material; in group 2: Metapex, no solvent; in group 3: Metapex+ethanol solvent; in group 4: ZOE, no solvent; in group 5: ZOE+ethanol solvent; and in group 6: ZOE+orange oi...
Source: Biomed Res - April 19, 2021 Category: Research Authors: Taraneh Zeynalzade Ghouchani Hajar Farhadpour Najmeh Mohammadi Source Type: research

MiR-502 Suppresses TNF- < em > α < /em > -Induced Nucleus Pulposus Cell Apoptosis by Targeting TARF2
This study is aimed at investigating the role of microRNAs (miRNAs) in regulating human nucleus pulposus (NP) cell injury induced by tumor necrosis factor- (TNF-) α in IVDD. In this study, we induced NP cells with 20 ng/mL TNF-α in vitro, which promoted the obvious apoptosis of NP cells and the activation of nuclear transcription factor (NF)-κB. In contrast, using the specific NF-κB inhibitor BAY 11-7082 to treat cells greatly impaired the activation of NF-κB and increased the sensitivity of NP cells to TNF-α-induced apoptosis. Moreover, both TNF-α and BAY 11-7082 treatments were a...
Source: Biomed Res - April 19, 2021 Category: Research Authors: Zhao Guo Wen-Shan Gao Yun-Fei Wang Fei Gao Wei Wang Wen-Yuan Ding Source Type: research

circSLC8A1 Acts as a Tumor Suppressor in Prostate Cancer via Sponging miR-21
CONCLUSIONS: CircSLC8A1 functioned as an inhibitor of neoplasm via modulating the miR-21 and might serve as a prospective target for the treatment of PCa.PMID:33869627 | PMC:PMC8035017 | DOI:10.1155/2021/6614591 (Source: Biomed Res)
Source: Biomed Res - April 19, 2021 Category: Research Authors: Daoyuan Wang Shuxian Yan Lihui Wang Yunlong Li Baoping Qiao Source Type: research

Outcome Analysis of Intramedullary Nailing Augmented with Poller Screws for Treating Difficult Reduction Fractures of Femur and Tibia: a Retrospective Cohort Study
CONCLUSION: Poller screw augmentation of IM nailing is a favourable option to shorten fracture healing time and to reduce complication rates in terms of nonunion, malunion, and secondary surgical procedure in the treatment of both diaphyseal/metaphyseal fractures of the femur or tibia while compare with those treated by IM nailing alone.PMID:33869628 | PMC:PMC8035000 | DOI:10.1155/2021/6615776 (Source: Biomed Res)
Source: Biomed Res - April 19, 2021 Category: Research Authors: Junfei Guo Junpu Zha Jun Di Yingchao Yin Zhiyong Hou Yingze Zhang Source Type: research

Small Molecule "Silmitasertib" Repurposed as Inhibitor of Transforming Growth Factor Beta 1 for the Development of Therapeutics for Oral Submucous Fibrosis
Biomed Res Int. 2021 Apr 1;2021:6631848. doi: 10.1155/2021/6631848. eCollection 2021.ABSTRACTOral submucous fibrosis (OSMF) is considered a premalignant condition characterized by aggressive fibrosis of the submucosal tissues of the oral cavity reflecting its malignant transformation potential. Activation of transforming growth factor beta (TGF-β) signaling has been reported to lead increased collagen production and fibrosis. Recently, significant upregulation of TGF-β1 has been reported in OSMF as compared to normal tissues. Therefore, inhibition of the TGF-β1 may pave for the development of therapeutics of...
Source: Biomed Res - April 19, 2021 Category: Research Authors: Nezar Boreak Source Type: research

Shared Molecular Mechanisms between Alzheimer's Disease and Periodontitis Revealed by Transcriptomic Analysis
CONCLUSIONS: Exploration of available transcriptomic datasets revealed C4A, C4B, CXCL12, FCGR3A, IL1B, and MMP3 as the top candidate molecular linkage genes between periodontitis and AD.PMID:33869630 | PMC:PMC8032519 | DOI:10.1155/2021/6633563 (Source: Biomed Res)
Source: Biomed Res - April 19, 2021 Category: Research Authors: Jieqi Jin Mengkai Guang Anthony Chukwunonso Ogbuehi Simin Li Kai Zhang Yihong Ma Aneesha Acharya Bihan Guo Zongwu Peng Xiangqiong Liu Yupei Deng Zhaobi Fang Xiongjie Zhu Shiting Hua Cong Li Rainer Haak Dirk Ziebolz Gerhard Schmalz Lei Liu Baohua Xu Xiaofe Source Type: research

Maternal Prepregnancy Weight and Pregnancy Outcomes in Saudi Women: Subgroup Analysis from Riyadh Mother and Baby Cohort Study (RAHMA)
Conclusion. The prevalence of prepregnancy overweight and obesity is very high in Saudi Arabia. Prepregnancy obesity is associated with GDM and hypertensive events inpregnancy, IOL, failed IOL, and CS delivery. Infants of obese mothers were at higher risk of macrosomia, while underweight women were at increased risk of delivering LBW infants.PMID:33869631 | PMC:PMC8034996 | DOI:10.1155/2021/6655942 (Source: Biomed Res)
Source: Biomed Res - April 19, 2021 Category: Research Authors: Hayfaa Wahabi Samia Esmaeil Amel Fayed Source Type: research

Identification of a Gene Prognostic Signature for Oral Squamous Cell Carcinoma by RNA Sequencing and Bioinformatics
CONCLUSIONS: We successfully constructed a prognostic signature to predict prognosis and identified five candidate genes associated with the OS of OSCC patients that are potential tumor biomarkers and targets in OSCC.PMID:33869632 | PMC:PMC8032525 | DOI:10.1155/2021/6657767 (Source: Biomed Res)
Source: Biomed Res - April 19, 2021 Category: Research Authors: Yang-Yang Zhang Ming-Hui Mao Zheng-Xue Han Source Type: research

Potential Health Risks of Macro- and Microelements in Commercial Medicinal Plants Used to Treatment of Diabetes
The objectives of this study were to determine the levels of macroelements and microelements in three different medicinal plant species including the dry samples and teas from Bauhinia forficata, Eleusine Indica, and Orthosiphon stamineus and assess the human health risks of ingestion of the tea. The content of the dry samples and teas was obtained using the technique of inductively coupled plasma optical emission spectrometry (ICP OES) after microwave digestion procedure. The hazard quotient (HQ) method was used to access the human health risks posed by heavy metal through tea consumption. The results revealed the presenc...
Source: Biomed Res - April 19, 2021 Category: Research Authors: Igor D de Souza Elaine S P Melo Valdir Arag ão Nascimento Hugo S Pereira Kassia R N Silva Paulo R Espindola Paula F S Tschinkel Eliza M Ramos Francisco J M Reis Iara B Ramos Fernanda G Paula Karla R W Oliveira Cleberson D Lima Ângela A Nunes Valter Arag Source Type: research

Awareness of and Preferences for Preexposure Prophylaxis (PrEP) among MSM at High Risk of HIV Infection in Southern China: Findings from the T2T Study
This study is aimed at investigating the awareness of and preferences for oral and long-acting injectable HIV preexposure prophylaxis (PrEP) and their associated factors among men who have sex with men (MSM) at high risk of HIV infection in southern China. A cross-sectional survey was conducted among 603 MSM who were recruited through a cohort study called the T2T Study at three sexual health clinics in Guangzhou, Shenzhen, and Wuxi, China, from 2017 to 2018. We collected information on HIV-negative participants' awareness of and willingness to use PrEP and its potential correlations. Univariate and multivariate logistic r...
Source: Biomed Res - April 19, 2021 Category: Research Authors: Weiying Chen Yi Ding Jianghao Chen Peipei Zhao Zhenyu Wang Xiaojun Meng Tianjian Jia Heping Zheng Bin Yang Zhenzhou Luo Huachun Zou Source Type: research

< sup > 18 < /sup > F-FDG-PET/CT Whole-Body Imaging Lung Tumor Diagnostic Model: An Ensemble E-ResNet-NRC with Divided Sample Space
Biomed Res Int. 2021 Apr 1;2021:8865237. doi: 10.1155/2021/8865237. eCollection 2021.ABSTRACTUnder the background of 18F-FDG-PET/CT multimodal whole-body imaging for lung tumor diagnosis, for the problems of network degradation and high dimension features during convolutional neural network (CNN) training, beginning with the perspective of dividing sample space, an E-ResNet-NRC (ensemble ResNet nonnegative representation classifier) model is proposed in this paper. The model includes the following steps: (1) Parameters of a pretrained ResNet model are initialized using transfer learning. (2) Samples are divided into three ...
Source: Biomed Res - April 19, 2021 Category: Research Authors: Zhou Tao Huo Bing-Qiang Lu Huiling Shi Hongbin Yang Pengfei Ding Hongsheng Source Type: research

Factors Influencing Utilization of HIV Testing Services among Boda-Boda Riders in Kabarole District, Southwestern Uganda: A Cross-Sectional Study
CONCLUSIONS: Utilization of HIV testing services among the boda-boda riders in Fort Portal Municipality, Southwestern Uganda, was high. More efforts should focus on targeting older boda-boda riders for HIV testing, reduction of HIV-related stigma, improving knowledge on HIV/AIDS, and encouraging communication and disclosure between partners, in order to consolidate the gains made in HIV testing services in this bridge population.PMID:33869636 | PMC:PMC8035009 | DOI:10.1155/2021/8877402 (Source: Biomed Res)
Source: Biomed Res - April 19, 2021 Category: Research Authors: Vicent Ssekankya Stanley Kamau Githaiga Timothy Aleko Esther Faith Munguciada Vivian Patience Nabakka Jolly Justine Kyalisiima Alex Ndyabakira Richard Migisha Source Type: research

Cationic chitosan-modified silica nanoparticles for oral delivery of protein vaccine
J Biomed Mater Res A. 2021 Apr 19. doi: 10.1002/jbm.a.37198. Online ahead of print.ABSTRACTMesoporous silica nanoparticles coated with Chitosan are exploited here as a potential carrier for oral vaccine delivery. Bovine serum albumin (BSA) was used as a protein antigen model to reveal the carrier property. Chitosan-coated BSA-loaded silica NPs had particle size 345 ± 60 nm with a cationic surface charge of 18.28 ± 0.71 mV. The encapsulation efficiency, drug loading was 25.34 ± 0.76 and 20.21 ± 0.48%, respectively. Transmission electron microscopy investigation showed the spherical shape of NPs, ...
Source: Biomed Res - April 19, 2021 Category: Research Authors: Xi Wu Muhammad Asim Farooq Tiantian Li Tianjiao Geng Perpeuta Takunda Kutoka Bo Wang Source Type: research

Monitoring mechanical stimulation for optimal tendon tissue engineering: A mechanical and biological multiscale study
J Biomed Mater Res A. 2021 Apr 19. doi: 10.1002/jbm.a.37180. Online ahead of print.ABSTRACTTo understand the effect of mechanical stimulation on cell response, bone marrow stromal cells were cultured on electrospun scaffolds under two distinct mechanical conditions (static and dynamic). Comparison between initial and final mechanical and biological properties of the cell-constructs were conducted over 14 days for both culturing conditions. As a result, mechanically stimulated constructs, in contrast to their static counterparts, showed evident mechanical-induced cell orientation, an effective aligned collagen and tenomodul...
Source: Biomed Res - April 19, 2021 Category: Research Authors: Alejandro Garcia Garcia Jean-Baptiste Perot Megane Beldjilali-Labro Quentin Dermigny Marie Naudot Sophie Le Ricousse Cecile Legallais Fahmi Bedoui Source Type: research

Zinc- and strontium- co-incorporated nanorods on titanium surfaces with favorable material property, osteogenesis, and enhanced antibacterial activity
In this study, co-incorporated zinc- (Zn-) and strontium- (Sr-) nanorod coating on sandblasted and acid-etched (SLA) titanium (SLA-Zn/Sr) was fabricated by hydrothermal synthesis. It was aimed at promoting osteogenesis while inhibiting biofilm formation. The nanorod-like particles (φ 30-50 nm) were found to be evenly formed on SLA-Zn/Sr (Zn: 1.49 ± 0.16 wt%; Sr: 21.69 ± 2.74 wt%) that was composed of well-crystallized ZnTiO3 and SrTiO3 phases. With a sufficient interface bonding strength (42.00 ± 3.00 MPa), SLA-Zn/Sr enhanced the corrosion resistance property of titanium. Besides, SLA-Zn/Sr promote...
Source: Biomed Res - April 19, 2021 Category: Research Authors: Yanqi Chen Chuan Zhou Yiwen Xie Antian Xu Ye Guan Wei Lu Xiaoxiang Wang Fuming He Source Type: research

In vitro evaluation of loaded chitosan membranes for pain relief and infection prevention
This study sought to evaluate hexanoic acid-treated electrospun chitosan membranes (HA-ESCM) as wound dressings that release C2DA and bupivacaine to simultaneously prevent infection and alleviate pain associated with musculoskeletal trauma. Release profiles of both therapeutics were evaluated, and membranes were tested in vitro against Methicillin-resistant Staphylococcus aureus (MRSA) to determine efficacy in preventing biofilm infection and bacterial growth. Results indicate that membranes release both therapeutics for 72 hr, and release profile can be tailored by loading concentration. Membranes were effective in preven...
Source: Biomed Res - April 19, 2021 Category: Research Authors: Zoe L Harrison Joel D Bumgardner Tomoko Fujiwara Daniel L Baker J Amber Jennings Source Type: research

Surface modifications to enhance osseointegration-Resulting material properties and biological responses
J Biomed Mater Res B Appl Biomater. 2021 Apr 19. doi: 10.1002/jbm.b.34835. Online ahead of print.ABSTRACTAs life expectancy and the age of the general population increases so does the need for improved implants. A major contributor to the failure of implants is poor osseointegration, which is typically described as the direct connection between bone and implant. This leads to unnecessary complications and an increased burden on the patient population. Modification of the implant surfaces through novel techniques, such as varying topography and/or applying coatings, has become a popular method to enhance the osseointegratio...
Source: Biomed Res - April 19, 2021 Category: Research Authors: Kadie P Nobles Amol V Janorkar Randall S Williamson Source Type: research

Effect of radio frequency glow-discharge treatment of titanium on human gingival fibroblasts as a function of distance
This study investigated the in-vitro attachment and spreading of human gingival fibroblasts (HGF) on bacterial grade polystyrene (PS) at different distances from radio-frequency glow-discharge (RFGD)-treated commercially pure titanium (cpTi) specimens. Controls included sterile cpTi specimens without RFGD treatment. A second set of experiments utilized media transferred to new bacterial grade polystyrene dishes (no cpTi) after the medium was conditioned by exposure to cpTi, either with or without RFGD treatment, for 24 hr. Surface characterization of the dishes was conducted through contact angle measurements and infrared ...
Source: Biomed Res - April 19, 2021 Category: Research Authors: Aya Ali Michelle B Visser Mark T Ehrensberger Anne E Meyer Source Type: research

Tissue-engineering the larynx: Effect of decellularization on human laryngeal framework and the cricoarytenoid joint
This study demonstrates effective decellularization of human larynges as evidenced by significant DNA depletion and preservation of extracellular matrix, which are outcomes that are required for a biological scaffold to regenerate a non-immunogenic larynx. The decellularization process caused minimal weakness in the cricoarytenoid joints due to treatment with multiple detergents and enzymes in the decellularization protocol.PMID:33872461 | DOI:10.1002/jbm.b.34851 (Source: Biomed Res)
Source: Biomed Res - April 19, 2021 Category: Research Authors: Zaid Al-Qurayshi Emad I Wafa Henry Hoffman Kristi Chang Aliasger K Salem Source Type: research

A demonstration of using formal consensus methods within guideline development; a case study
CONCLUSION: Formal consensus is a valuable option for use within guideline development when specific criteria are met. The approach provides transparent methodology, ensuring clarity on how recommendations are developed.PMID:33865324 | DOI:10.1186/s12874-021-01267-0 (Source: Biomed Res)
Source: Biomed Res - April 18, 2021 Category: Research Authors: P Carter K J M O'Donoghue K Dworzynski L O'Shea V Roberts T Reeves A Bastounis M A Mugglestone J Fawke S Pilling Source Type: research

Gasoline-station workers in Brazil: Benzene exposure; Genotoxic and immunotoxic effects
Mutat Res. 2021 May;865:503322. doi: 10.1016/j.mrgentox.2021.503322. Epub 2021 Feb 1.ABSTRACTChronic exposure to benzene is a risk factor for hematological malignancies. Gasoline-station workers are exposed to benzene in gasoline, via both inhalation and dermal contact (attendants and managers) or inhalation (workers in the on-site convenience stores and offices). We have studied the exposure of these workers to benzene and the resulting genotoxic and immunotoxic effects. Levels of urinary trans, trans-muconic acid were higher among gasoline-station workers than among office workers with no known exposure to benzene (compa...
Source: Biomed Res - April 18, 2021 Category: Research Authors: Katia Soares da Po ça Isabela Giardini Paula Vieira Baptista Silva Barbara Rodrigues Geraldino Antonella Bellomo Julia Ara újo Alves Taline Ramos Conde Helena Pereira da Silva Zamith Ubirani Barros Otero Fausto Klabund Ferraris Karen Friedrich Marcia Sa Source Type: research

Injectable open-porous PLGA microspheres as cell carriers for cartilage regeneration
J Biomed Mater Res A. 2021 Apr 18. doi: 10.1002/jbm.a.37196. Online ahead of print.ABSTRACTMinimally invasive treatment via injectable delivery of cells has drawn extensive attention for tissue regeneration because it reduces the need for substantial open surgery and fits tissue defects with complex shapes, making it a suitable option for repairing articular cartilage defects. This work presents an alkaline treatment method to fabricate open-porous poly (lactic-co-glycolic acid) microspheres (OPMs) as bone marrow stromal cells (BMSCs) carriers for cartilage regeneration. OPMs have better biodegradation property and the ext...
Source: Biomed Res - April 18, 2021 Category: Research Authors: Moyuan Qu Xiaoling Liao Nan Jiang Wujin Sun Wenqian Xiao Xingwu Zhou Ali Khademhosseini Bo Li Songsong Zhu Source Type: research

Characterization and optimization of de-esterified Tragacanth-chitosan nanocomposite as a potential carrier for oral delivery of insulin: In vitro and ex vivo studies
In this study, for the first time, a nano-carrier for controlled and targeted oral delivery of insulin was developed using de-esterified Tragacanth and chitosan. The fabricated nanoparticles were synthesized using coacervation technique and their properties were optimized using response surface methodology. The effect of experimental variables on the particle size and loading efficiency was examined. In addition, the interactions between components were analyzed using Fourier transform infrared. The thermal stability of nanoparticles was studied by thermal gravimetric analysis. The insulin loading efficiency was measured a...
Source: Biomed Res - April 18, 2021 Category: Research Authors: Touraj Shirzadian Mohammad Sadegh Nourbakhsh Ali Fattahi Gholamreza Bahrami Ghobad Mohammadi Source Type: research

A demonstration of using formal consensus methods within guideline development; a case study
CONCLUSION: Formal consensus is a valuable option for use within guideline development when specific criteria are met. The approach provides transparent methodology, ensuring clarity on how recommendations are developed.PMID:33865324 | DOI:10.1186/s12874-021-01267-0 (Source: Biomed Res)
Source: Biomed Res - April 18, 2021 Category: Research Authors: P Carter K J M O'Donoghue K Dworzynski L O'Shea V Roberts T Reeves A Bastounis M A Mugglestone J Fawke S Pilling Source Type: research

Gasoline-station workers in Brazil: Benzene exposure; Genotoxic and immunotoxic effects
Mutat Res. 2021 May;865:503322. doi: 10.1016/j.mrgentox.2021.503322. Epub 2021 Feb 1.ABSTRACTChronic exposure to benzene is a risk factor for hematological malignancies. Gasoline-station workers are exposed to benzene in gasoline, via both inhalation and dermal contact (attendants and managers) or inhalation (workers in the on-site convenience stores and offices). We have studied the exposure of these workers to benzene and the resulting genotoxic and immunotoxic effects. Levels of urinary trans, trans-muconic acid were higher among gasoline-station workers than among office workers with no known exposure to benzene (compa...
Source: Biomed Res - April 18, 2021 Category: Research Authors: Katia Soares da Po ça Isabela Giardini Paula Vieira Baptista Silva Barbara Rodrigues Geraldino Antonella Bellomo Julia Ara újo Alves Taline Ramos Conde Helena Pereira da Silva Zamith Ubirani Barros Otero Fausto Klabund Ferraris Karen Friedrich Marcia Sa Source Type: research

Injectable open-porous PLGA microspheres as cell carriers for cartilage regeneration
J Biomed Mater Res A. 2021 Apr 18. doi: 10.1002/jbm.a.37196. Online ahead of print.ABSTRACTMinimally invasive treatment via injectable delivery of cells has drawn extensive attention for tissue regeneration because it reduces the need for substantial open surgery and fits tissue defects with complex shapes, making it a suitable option for repairing articular cartilage defects. This work presents an alkaline treatment method to fabricate open-porous poly (lactic-co-glycolic acid) microspheres (OPMs) as bone marrow stromal cells (BMSCs) carriers for cartilage regeneration. OPMs have better biodegradation property and the ext...
Source: Biomed Res - April 18, 2021 Category: Research Authors: Moyuan Qu Xiaoling Liao Nan Jiang Wujin Sun Wenqian Xiao Xingwu Zhou Ali Khademhosseini Bo Li Songsong Zhu Source Type: research

Characterization and optimization of de-esterified Tragacanth-chitosan nanocomposite as a potential carrier for oral delivery of insulin: In vitro and ex vivo studies
In this study, for the first time, a nano-carrier for controlled and targeted oral delivery of insulin was developed using de-esterified Tragacanth and chitosan. The fabricated nanoparticles were synthesized using coacervation technique and their properties were optimized using response surface methodology. The effect of experimental variables on the particle size and loading efficiency was examined. In addition, the interactions between components were analyzed using Fourier transform infrared. The thermal stability of nanoparticles was studied by thermal gravimetric analysis. The insulin loading efficiency was measured a...
Source: Biomed Res - April 18, 2021 Category: Research Authors: Touraj Shirzadian Mohammad Sadegh Nourbakhsh Ali Fattahi Gholamreza Bahrami Ghobad Mohammadi Source Type: research

Proteolysis and inflammation of the kidney glomerulus
Cell Tissue Res. 2021 Apr 17. doi: 10.1007/s00441-021-03433-8. Online ahead of print.ABSTRACTProteases play a central role in regulating renal pathophysiology and are increasingly evaluated as actionable drug targets. Here, we review the role of proteolytic systems in inflammatory kidney disease. Inflammatory kidney diseases are associated with broad dysregulations of extracellular and intracellular proteolysis. As an example of a proteolytic system, the complement system plays a significant role in glomerular inflammatory kidney disease and is currently under clinical investigation. Based on two glomerular kidney diseases...
Source: Biomed Res - April 17, 2021 Category: Research Authors: Fatih Demir Anne Troldborg Steffen Thiel Moritz Lass é Pitter F Huesgen Nicola M Tomas Thorsten Wiech Markus M Rinschen Source Type: research

Proteolysis and inflammation of the kidney glomerulus
Cell Tissue Res. 2021 Apr 17. doi: 10.1007/s00441-021-03433-8. Online ahead of print.ABSTRACTProteases play a central role in regulating renal pathophysiology and are increasingly evaluated as actionable drug targets. Here, we review the role of proteolytic systems in inflammatory kidney disease. Inflammatory kidney diseases are associated with broad dysregulations of extracellular and intracellular proteolysis. As an example of a proteolytic system, the complement system plays a significant role in glomerular inflammatory kidney disease and is currently under clinical investigation. Based on two glomerular kidney diseases...
Source: Biomed Res - April 17, 2021 Category: Research Authors: Fatih Demir Anne Troldborg Steffen Thiel Moritz Lass é Pitter F Huesgen Nicola M Tomas Thorsten Wiech Markus M Rinschen Source Type: research

The Alveolar Ridge Splitting Technique on Maxillae: A Biomechanical Human Cadaveric Investigation
Biomed Res Int. 2020 Nov 19;2020:8894471. doi: 10.1155/2020/8894471. eCollection 2020.ABSTRACTThe alveolar ridge splitting technique (ARST) offers an alternative to classic ridge augmentation techniques for successful insertion of dental implants. However, the buccal lamella is at risk of fracturing during ARST distraction. To better understand the fracture mechanisms and displacement limits of the split lamella, this study conducted biomechanical tests on human cadaveric maxilla specimens having extremely atrophied alveolar ridges treated with ARST. A total of 12 standardized alveolar splits were prepared on the maxillae ...
Source: Biomed Res - April 16, 2021 Category: Research Authors: Fabian Duttenhoefer Peter Varga Dominik Jenni Leonard Gr ünwald Luisa Thiemann Boyko Gueorguiev Andres Stricker Source Type: research

Development and Evaluation of Nomograms to Predict the Cancer-Specific Mortality and Overall Mortality of Patients with Hepatocellular Carcinoma
Biomed Res Int. 2021 Mar 29;2021:1658403. doi: 10.1155/2021/1658403. eCollection 2021.ABSTRACTHepatocellular carcinoma (HCC) is the most common type among primary liver cancers (PLC). With its poor prognosis and survival rate, it is necessary for HCC patients to have a long-term follow-up. We believe that there are currently no relevant reports or literature about nomograms for predicting the cancer-specific mortality of HCC patients. Therefore, the primary goal of this study was to develop and evaluate nomograms to predict cancer-specific mortality and overall mortality. Data of 45,158 cases of HCC patients were collected...
Source: Biomed Res - April 16, 2021 Category: Research Authors: Xiaofeng Ni Ding Li Shengjie Dai Hao Pan Hongwei Sun Jianyang Ao Lei Chen Hongru Kong Source Type: research

Comparison between Smoking and Nonsmoking Palestinian Medical Students in the Health-Promoting Behaviors and Lifestyle Characteristics
CONCLUSION: The significant lower total Health-Promoting Lifestyle Profile-II score in smoking students necessitates the urgent need for awareness programs, not only towards smoking but also on how to enhance student health-promoting lifestyle behaviors.PMID:33860032 | PMC:PMC8009719 | DOI:10.1155/2021/5536893 (Source: Biomed Res)
Source: Biomed Res - April 16, 2021 Category: Research Authors: Nihad Al-Othman Mustafa Ghanim Moath Alqaraleh Source Type: research

Beneficial Effect of Statin Therapy on Arterial Stiffness
Biomed Res Int. 2021 Mar 30;2021:5548310. doi: 10.1155/2021/5548310. eCollection 2021.ABSTRACTArterial stiffness describes the increased rigidity of the arterial wall that occurs as a consequence of biological aging and several diseases. Numerous studies have demonstrated that parameters to assess arterial stiffness, especially pulse-wave velocity, are predictive of those individuals that will suffer cardiovascular morbidity and mortality. Statin therapy may be a pharmacological strategy to improve arterial elasticity. It has been shown that the positive benefits of statin therapy on cardiovascular disease is attributable ...
Source: Biomed Res - April 16, 2021 Category: Research Authors: Mona Alidadi Fabrizio Montecucco Tannaz Jamialahmadi Khalid Al-Rasadi Thomas P Johnston Amirhossein Sahebkar Source Type: research

miR-543 Inhibits the Occurrence and Development of Intrauterine Adhesion by Inhibiting the Proliferation, Migration, and Invasion of Endometrial Cells
CONCLUSION: During the formation of intrauterine adhesions, the expression of CDH2, COL16A1, vimentin, and α-SMA may be inhibited by the high expression of miR-543, which may affect the degree of fibrosis and collagen content in the intrauterine adhesions, thereby inhibiting the occurrence and development of intrauterine adhesions.PMID:33860034 | PMC:PMC8024079 | DOI:10.1155/2021/5559102 (Source: Biomed Res)
Source: Biomed Res - April 16, 2021 Category: Research Authors: Xin Liu Qian Xu Chao Chen Hua Duan Source Type: research

Clinical Efficacy and Safety of "Three-Dimensional Balanced Manipulation" in the Treatment of Cervical Spondylotic Radiculopathy by Finite Element Analysis
Biomed Res Int. 2021 Mar 31;2021:5563296. doi: 10.1155/2021/5563296. eCollection 2021.ABSTRACTCervical spondylotic radiculopathy (CSR) is the most commonly encountered cervical spine disorder. Cervical manipulation has been demonstrated as an effective therapy for patients. However, the mechanisms of manipulations have not been elucidated. A total of 120 cervical spondylotic radiculopathy patients were divided into the "three-dimensional balanced manipulation" treatment group (TBM group) and control group randomly. The control group was treated with traditional massage; the TBM treatment group was treated with &q...
Source: Biomed Res - April 16, 2021 Category: Research Authors: Shengnan Cao Yuanzhen Chen Feng Zhang Shifei Sun Congan Wang Guangjian Hou Dandan Wang Guodong Sun Bin Shi Source Type: research

Cediranib Induces Apoptosis, G1 Phase Cell Cycle Arrest, and Autophagy in Non-Small-Cell Lung Cancer Cell A549 In Vitro
Biomed Res Int. 2021 Mar 29;2021:5582648. doi: 10.1155/2021/5582648. eCollection 2021.ABSTRACTLung cancer remains the leading cause of cancer death worldwide. Late diagnosis, chemoresistance, and metastasis are the main reasons for the high mortality rate of lung cancer. Therefore, the development of other treatments is urgent. Cediranib (CED), a vascular endothelial growth factor receptor (VEGFR) kinase inhibitor, shows promising antitumour activities in various cancers including lung cancer. Here, we explored the effects and the underlying molecular mechanism of CED on non-small-cell lung cancer (NSCLC) cell line A549 ce...
Source: Biomed Res - April 16, 2021 Category: Research Authors: Menghuan Guo Zhiyuan Liu Jing Si Jinhua Zhang Jin Zhao Zhong Guo Yi Xie Hong Zhang Lu Gan Source Type: research

Differential Expression Profiles and Function Prediction of Transfer RNA-Derived Fragments in High-Grade Serous Ovarian Cancer
CONCLUSIONS: There are significantly expressed tRFs and tiRNAs in HGSOC tissues, and these may provide potential diagnostic biomarkers and therapeutic targets for HGSOC.PMID:33860037 | PMC:PMC8028742 | DOI:10.1155/2021/5594081 (Source: Biomed Res)
Source: Biomed Res - April 16, 2021 Category: Research Authors: Buze Chen Sicong Liu Haihong Wang Guilin Li Xiaoyuan Lu Hao Xu Source Type: research

Corrigendum to "Association between Frailty and Erectile Dysfunction among Chinese Elderly Men"
Biomed Res Int. 2021 Mar 13;2021:5736092. doi: 10.1155/2021/5736092. eCollection 2021.ABSTRACT[This corrects the article DOI: 10.1155/2020/9247237.].PMID:33860038 | PMC:PMC8009701 | DOI:10.1155/2021/5736092 (Source: Biomed Res)
Source: Biomed Res - April 16, 2021 Category: Research Authors: Chengfu Li Ji Sun Huameng Zhao Tingshan Dai Source Type: research

Bioinformatic Analysis of Key Genes and Pathways Related to Keloids
CONCLUSION: This study identified several hub genes and provided insights for the underlying pathways and miRNA-hub gene interactions for keloid development through bioinformatic analysis of two microarray datasets. Additionally, our results would support the development of future therapeutic strategies.PMID:33860039 | PMC:PMC8009712 | DOI:10.1155/2021/5897907 (Source: Biomed Res)
Source: Biomed Res - April 16, 2021 Category: Research Authors: Siwei Bi Ruiqi Liu Beiyi Wu Linfeng He Jun Gu Source Type: research

The Relationship between Hepatic Myeloid-Derived Suppressor Cells and Clinicopathological Parameters in Patients with Chronic Liver Disease
Biomed Res Int. 2021 Mar 29;2021:6612477. doi: 10.1155/2021/6612477. eCollection 2021.ABSTRACTMyeloid-derived suppressor cells (MDSCs) have attracted attention due to their important role in inflammation. Several studies have investigated the involvement of MDSCs in chronic liver disease. However, due to the difference of MDSC phenotypes, patient types, and sample sources among the studies, the results are inconsistent and controversial. We took advantage of a large well-defined cohort of 98 (24 patients with CHB, 18 with NAFLD, 13 with HCC, 16 with PBC, and 27 with AIH) patients with liver inflammation and 12 healthy cont...
Source: Biomed Res - April 16, 2021 Category: Research Authors: Zhijia Zhou Penghua Lai Shaoliang Zhang Yujie Wang Ning Qu Dawei Lu Liangqin Gao Lingxia Xu Yanmiao Yang Ting Zhang Xue Sun Xiaoting Zheng Yaoyu Liu Huiqing Liang Shaodong Chen Source Type: research

Helicobacter Pylori Variants with ABC-Type Tyrosine Phosphorylation Motif in Gastric Biopsies of Ghanaian Patients
CONCLUSIONS: H. pylori identified were Western variant (ABC type) with unique amino acid insertions, suggesting unique variants in Ghanaian patients. Further investigation is however required to understand the role of the molecular diversity of the variant in gastric disease outcome.PMID:33860041 | PMC:PMC8026283 | DOI:10.1155/2021/6616059 (Source: Biomed Res)
Source: Biomed Res - April 16, 2021 Category: Research Authors: Emmanuel A Tagoe Gordon A Awandare Osbourne Quaye Richard H Asmah Timothy N Archampong Mahasin A Osman Charles A Brown Source Type: research

Treating Lumbar Fracture Using the Mixed Reality Technique
Biomed Res Int. 2021 Mar 29;2021:6620746. doi: 10.1155/2021/6620746. eCollection 2021.ABSTRACTThe mixed reality (MR) technique has recently been widely used in the orthopedic surgery with satisfactory results reported. However, few studies have focused on the application of MR in the Lumbar fracture (LF). In this retrospective study, our aim is to analyze some findings by investigating the feasibility of MR applied to lumbar fracture treatment. Posterior vertebrectomy has been operated on 7 patients. The MR-based intraoperative three-dimensional image-guided navigation system (MITINS) was used to assist implantation of ped...
Source: Biomed Res - April 16, 2021 Category: Research Authors: Jiaheng Li Hexing Zhang Qiang Li Shuangqi Yu Wei Chen Song Wan Dong Chen Rong Liu Fan Ding Source Type: research

SSCA-Net: Simultaneous Self- and Channel-Attention Neural Network for Multiscale Structure-Preserving Vessel Segmentation
Biomed Res Int. 2021 Mar 30;2021:6622253. doi: 10.1155/2021/6622253. eCollection 2021.ABSTRACTVessel segmentation is a fundamental, yet not well-solved problem in medical image analysis, due to the complicated geometrical and topological structures of human vessels. Unlike existing rule- and conventional learning-based techniques, which hardly capture the location of tiny vessel structures and perceive their global spatial structures, we propose Simultaneous Self- and Channel-attention Neural Network (termed SSCA-Net) to solve the multiscale structure-preserving vessel segmentation (MSVS) problem. SSCA-Net differs from the...
Source: Biomed Res - April 16, 2021 Category: Research Authors: Jiajia Ni Jianhuang Wu Jing Tong Mingqiang Wei Zhengming Chen Source Type: research

Bioelectrical Impedance Analysis and Manual Measurements of Neck Circumference Are Interchangeable, and Declining Neck Circumference Is Related to Presarcopenia
CONCLUSIONS: BIA measurements of NC are interchangeable within about 95% with manual measurements. The decrease in NC measured by BIA was significantly associated with presarcopenia in both genders. NC measurement can be used for early detection of presarcopenia.PMID:33860044 | PMC:PMC8024069 | DOI:10.1155/2021/6622398 (Source: Biomed Res)
Source: Biomed Res - April 16, 2021 Category: Research Authors: Masaaki Machino Kei Ando Kazuyoshi Kobayashi Hiroaki Nakashima Satoshi Tanaka Shunsuke Kanbara Sadayuki Ito Taro Inoue Hiroyuki Koshimizu Taisuke Seki Shinya Ishizuka Yasuhiko Takegami Yukiharu Hasegawa Shiro Imagama Source Type: research

Human Schlafen 5 Inhibits Proliferation and Promotes Apoptosis in Lung Adenocarcinoma via the PTEN/PI3K/AKT/mTOR Pathway
In conclusion, these suggest that human SLFN5 plays inhibitory roles in LUAC progression through the PTEN/PI3K/AKT/mTOR pathway, providing a potential target for developing drugs for lung cancer therapy in the future.PMID:33860045 | PMC:PMC8009730 | DOI:10.1155/2021/6628682 (Source: Biomed Res)
Source: Biomed Res - April 16, 2021 Category: Research Authors: Xuefeng Gu Li Zhou Lei Chen Huiqing Pan Rui Zhao Weiwei Guang Guoqing Wan Peng Zhang Dingsheng Liu Li-Li Deng Weiming Zhao Changlian Lu Source Type: research

Electroacupuncture Inhibits Autophagy of Neuron Cells in Postherpetic Neuralgia by Increasing the Expression of miR-223-3p
In this study, we investigated the effect and underlying mechanism of EA on PHN. Sprague-Dawley rats were treated with resiniferatoxin (RTX) to establish a PHN model and subjected to EA and/or miR-223-3p overexpression (OV) or interference. Mechanical withdrawal latency was measured as an indication of pain sensitivity. Hematoxylin-eosin staining and transmission electron microscopy were performed to observe neuron cell morphology and autophagic vacuoles, respectively. ELISA was performed to detect reactive oxygen species (ROS) production and the levels of tumor necrosis factor- (TNF-) α, inducible nitric oxide synth...
Source: Biomed Res - April 16, 2021 Category: Research Authors: Jing Zou Xueyang Dong Ke Wang Jing Shi Ning Sun Source Type: research

Morphology of Sella Turcica and Bridging Prevalence Correlated with Sex and Craniofacial Skeletal Pattern in Eastern Asia Population: CBCT Study
Biomed Res Int. 2021 Mar 22;2021:6646406. doi: 10.1155/2021/6646406. eCollection 2021.ABSTRACTPURPOSE: Sella turcica bridging (STB) refers to a rare anatomical variation formed by the ossification of the ligament between the anterior and posterior clinoid processes. The presence of the STB was significantly correlated with craniofacial skeleton classification and a higher prevalence rate in skeletal Class III. The current study is aimed at investigating the dimensions of sella turcica and the prevalence of STB in different sexes and on the three craniofacial skeletal patterns using cone beam computed tomography (CBCT).MATE...
Source: Biomed Res - April 16, 2021 Category: Research Authors: Szu-Ting Chou Chun-Ming Chen Ping-Ho Chen Yuk-Kwan Chen Shis-Chieh Chen Yu-Chuan Tseng Source Type: research

Multiomics Analysis of Transcriptome, Epigenome, and Genome Uncovers Putative Mechanisms for Dilated Cardiomyopathy
CONCLUSION: Our findings comprehensively analyzed molecular characteristics from the transcriptome, epigenome, and genome perspectives for DCM, which could provide practical implications for DCM.PMID:33860048 | PMC:PMC8024089 | DOI:10.1155/2021/6653802 (Source: Biomed Res)
Source: Biomed Res - April 16, 2021 Category: Research Authors: Li Liu Jianjun Huang Yan Liu Xingshou Pan Zhile Li Liufang Zhou Tengfang Lai Chengcai Chen Baomin Wei Jianjiao Mo Qinjiang Wei Wei Yan Xiannan Huang Zhen Zhang Zhuohua Zhang Meidan Huang Fengzhen He Zhaohe Huang Source Type: research

Ginkgo Biloba Extract EGB761 Ameliorates the Extracellular Matrix Accumulation and Mesenchymal Transformation of Renal Tubules in Diabetic Kidney Disease by Inhibiting Endoplasmic Reticulum Stress
Biomed Res Int. 2021 Mar 23;2021:6657206. doi: 10.1155/2021/6657206. eCollection 2021.ABSTRACTThe study is aimed at investigating the effects of Ginkgo biloba extract EGB761 on renal tubular damage and endoplasmic reticulum stress (ERS) in diabetic kidney disease (DKD). A total of 50 C57BL/6 N mice were randomly divided into the normal group, DKD group, DKD+EGB761 group (36 mg/kg), and DKD+4-phenylbutyrate (4-PBA) group (1 g/kg). The DKD model was replicated by high-fat diet combined with intraperitoneal injection of streptozotocin (STZ). Renal tubular epithelial cells (HK-2) were divided into the control group, high-gluco...
Source: Biomed Res - April 16, 2021 Category: Research Authors: Jiarui Han Xinxin Pang Xiujie Shi Yage Zhang Zining Peng Yufeng Xing Source Type: research