Evaluating the polymerization effectiveness and biocompatibility of bio-sourced, visible light-based photoinitiator systems
In this study, we evaluated the effectiveness of bio-sourced synergist candidates, with a focus on amino acids, due to their amine functional groups, in combination with two bio-sourced photoinitiator molecules: riboflavin and curcumin. We tested the effectiveness of these photoinitiator systems under both violet (405 nm) and blue (460-475 nm) light using photo-rheology. We found that several synergist candidates, namely lysine, arginine, and histidine, increased the polymerization effectiveness of riboflavin when used with both violet and blue light. With curcumin, we found that almost all tested synergist candidates slig...
Source: Biomed Res - April 4, 2024 Category: Research Authors: Rion J Wendland Matthew T Conway Kristan S Worthington Source Type: research
Intestinal Colonization by < em > Campylobacter jejuni < /em > , < em > Clostridium difficile < /em > , and < em > Clostridium perfringens < /em > among Commensal < em > Rattus norvegicus < /em > in the Urban Areas of Tehran, Iran
CONCLUSION: According to the findings, rats are the main reservoirs for diseases. Therefore, rodent control coupled with the implementation of surveillance systems should be prioritized for urban health.PMID:38572169 | PMC:PMC10990632 | DOI:10.1155/2024/2929315 (Source: Biomed Res)
Source: Biomed Res - April 4, 2024 Category: Research Authors: Taher Azimi Sina Nasrollahian Sahar Sabour Mehrdad Mosadegh Nahal Hadi Leila Azimi Fatemeh Fallah Mohammad Reza Pourmand Source Type: research
An < em > In Silico < /em > Cardiomyocyte Reveals the Impact of Changes in CaMKII Signalling on Cardiomyocyte Contraction Kinetics in Hypertrophic Cardiomyopathy
In conclusion, our model reveals that impaired crossbridge kinetics is accompanied by a negative mismatch between the ATP supply and demand ratio. This suggests that improving this ratio may reduce the incidence of sudden death in HCM.PMID:38567164 | PMC:PMC10985279 | DOI:10.1155/2024/6160554 (Source: Biomed Res)
Source: Biomed Res - April 3, 2024 Category: Research Authors: Ismail Adeniran Hafsa Wadee Hans Degens Source Type: research
Optimization of Interleukin-10 incorporation for dendritic cells embedded in Poly(ethylene glycol) hydrogels
J Biomed Mater Res A. 2024 Apr 1. doi: 10.1002/jbm.a.37714. Online ahead of print.ABSTRACTTranslational research in biomaterials and immunoengineering is leading to the development of novel advanced therapeutics to treat diseases such as cancer, autoimmunity, and viral infections. Dendritic cells (DCs) are at the center of these therapeutics given that they bridge innate and adaptive immunity. The biomaterial system developed herein uses a hydrogel carrier to deliver immunomodulatory DCs for amelioration of autoimmunity. This biomaterial vehicle is comprised of a poly (ethylene glycol)-4 arm maleimide (PEG-4MAL) hydrogels,...
Source: Biomed Res - April 2, 2024 Category: Research Authors: Fredrick Bulondo Julia E Babensee Source Type: research
Optimization of Interleukin-10 incorporation for dendritic cells embedded in Poly(ethylene glycol) hydrogels
J Biomed Mater Res A. 2024 Apr 1. doi: 10.1002/jbm.a.37714. Online ahead of print.ABSTRACTTranslational research in biomaterials and immunoengineering is leading to the development of novel advanced therapeutics to treat diseases such as cancer, autoimmunity, and viral infections. Dendritic cells (DCs) are at the center of these therapeutics given that they bridge innate and adaptive immunity. The biomaterial system developed herein uses a hydrogel carrier to deliver immunomodulatory DCs for amelioration of autoimmunity. This biomaterial vehicle is comprised of a poly (ethylene glycol)-4 arm maleimide (PEG-4MAL) hydrogels,...
Source: Biomed Res - April 2, 2024 Category: Research Authors: Fredrick Bulondo Julia E Babensee Source Type: research
Evaluation of the Effect of < em > Lactobacillus acidophilus < /em > ATCC 4356 Bacteriocin against < em > Staphylococcus aureus < /em >
CONCLUSION: The growth inhibition of S. aureus in overlay soft agar method may be due to the production of bacteriocin-like substances. The overlay soft agar method is a qualitative test, so there is a need for further study to optimize the conditions for the production of bacteriocin-like substances in the culture supernatant and precise comparison between the inhibitory activity and pheromone secretion of different strains.PMID:38559901 | PMC:PMC10980545 | DOI:10.1155/2024/4119960 (Source: Biomed Res)
Source: Biomed Res - April 1, 2024 Category: Research Authors: Zeinab Fagheei Aghmiyuni Horieh Saderi Parviz Owlia Navid Saidi Source Type: research
Enhancing the degradation rate and biomineralization nature of antiferromagnetic Fe-20Mn alloy by groove pressing
This study demonstrates that Fe-20Mn processed by GP has potential applications for the manufacture of biodegradable metallic implants.PMID:38560769 | DOI:10.1002/jbm.a.37711 (Source: Biomed Res)
Source: Biomed Res - April 1, 2024 Category: Research Authors: Manas Ranjan Sahu T S Sampath Kumar Uday Chakkingal Vimal Kumar Dewangan Mukesh Doble Source Type: research
Nicotinamide promotes the differentiation of functional corneal endothelial cells from human embryonic stem cells
Exp Eye Res. 2024 Mar 30:109883. doi: 10.1016/j.exer.2024.109883. Online ahead of print.ABSTRACTCorneal transplantation represents the primary therapeutic approach for managing corneal endothelial dysfunction, but corneal donors remain scarce. Anterior chamber cell injection emerges as a highly promising alternative strategy for corneal transplantation, with pluripotent stem cells (PSC) demonstrating considerable potential as an optimal cell source. Nevertheless, only a few studies have explored the differentiation of functional corneal endothelial-like cells originating from PSC. In this investigation, a chemical-defined ...
Source: Biomed Res - April 1, 2024 Category: Research Authors: Dulei Zou Ting Wang Wenjing Li Xin Wang Bochao Ma Xiangyue Hu Qingjun Zhou Zongyi Li Weiyun Shi Haoyun Duan Source Type: research
Indoxyl sulfate contributes to colorectal cancer cell proliferation and increased EGFR expression by activating AhR and Akt
This study found that indoxyl sulfate induced the proliferation of CRC-derived HCT-116 cells by activating the aryl hydrocarbon receptor (AhR) and the proto-oncogene Akt. The AhR antagonist CH223191 and Akt inhibitor MK2206 suppressed indoxyl sulfate-induced proliferation of HCT-116 cells. We also found that indoxyl sulfate upregulated epidermal growth factor receptor (EGFR) expression, which is associated with poor prognosis of CRC, whereas CH223191 and MK2206 repressed EGFR expression. Furthermore, indoxyl sulfate increased the sensitivity of CRC cells to EGF by upregulating EGFR expression. These findings suggest that i...
Source: Biomed Res - March 31, 2024 Category: Research Authors: Yu Ichisaka Shozo Yano Kohji Nishimura Toshimitsu Niwa Hidehisa Shimizu Source Type: research
Tenascin-X is increased with decreased expression of miR-378a-5p and miR-486-5p in mice fed a methionine-choline-deficient diet that induces hepatic fibrosis
In this study, we investigated Tnxb expression in livers with fibrosis caused by administration of a methionine-chorine-deficient (MCD) diet in mice. Whole transcriptome analysis showed that Tnxb was one of the genes with increased expression in livers of MCD diet-fed mice compared with that in livers of normal diet (ND)-fed mice. In microarray and subsequent microRNA (miRNA) network analyses, miR-378a-5p and miR-486-5p were identified in livers of MCD diet-fed mice as downregulated miRNAs, which have their predicted target sites in the 3' untranslated region of Tnxb mRNA and might suppress the translation of Tnxb mRNA. RT...
Source: Biomed Res - March 31, 2024 Category: Research Authors: Ken-Ichi Matsumoto Takuma Higuchi Mirei Umeki Masafumi Ono Shuji Sakamoto Source Type: research
Distribution and anti-nociceptive function of endomorphin-1 in the rat cranial sensory ganglia
Biomed Res. 2024;45(2):77-89. doi: 10.2220/biomedres.45.77.ABSTRACTDistribution of endomorphin-1 (EM-1) was immunohistochemically investigated in the rat cranial sensory ganglia. Small to medium-sized neurons in the trigeminal (TG), petrosal (PG), and jugular ganglia (JG) expressed EM-1-immunoreactivity. However, EM-1-immunoreactive (-ir) neurons were infrequent in the nodose ganglion. In the brainstem, EM-1-ir varicose fibers were detected in the superficial layer of the medullary dorsal horn and the caudal part of the nucleus tractus solitarius. By trichrome immunofluorescence analysis, approximately 70% of EM-1-ir neuro...
Source: Biomed Res - March 31, 2024 Category: Research Authors: Shun Sato Tadasu Sato Takehiro Yajima Daisuke Tachiya Tetsu Takahashi Shinnosuke Nogami Masahiro Saito Kensuke Yamauchi Hiroyuki Ichikawa Source Type: research
Using hemoglobin vesicles to treat operative hemorrhagic shock after pneu- monectomy in dog models: an experimental study
In this study, we aimed to investigate HbV function during hemorrhagic shock in lung resection and analyze the details of oxygen delivery. Left pneumonectomy was performed in dogs under mechanical ventilation, followed by rapid exsanguination of approximately 30% of the total circulating blood volume, which led to shock, reducing the mean arterial pressure (MAP) by approximately 60% of baseline. Subsequently, either 5% human serum albumin (HSA) or HbVs suspended in 5% HSA were infused for resuscitation. The MAP only recovered to 75% of baseline after HSA administration, but fully recovered (100%) after HbV administration, ...
Source: Biomed Res - March 31, 2024 Category: Research Authors: Kei Nakano Mitsutomo Kohno Hiroto Onozawa Ryo Hashimoto Kana Oiwa Ryota Masuda Masatoshi Yamaguchi Tai Hato Masazumi Watanabe Hirohisa Horinouchi Hiromi Sakai Koichi Kobayashi Masayuki Iwazaki Source Type: research
Indoxyl sulfate contributes to colorectal cancer cell proliferation and increased EGFR expression by activating AhR and Akt
This study found that indoxyl sulfate induced the proliferation of CRC-derived HCT-116 cells by activating the aryl hydrocarbon receptor (AhR) and the proto-oncogene Akt. The AhR antagonist CH223191 and Akt inhibitor MK2206 suppressed indoxyl sulfate-induced proliferation of HCT-116 cells. We also found that indoxyl sulfate upregulated epidermal growth factor receptor (EGFR) expression, which is associated with poor prognosis of CRC, whereas CH223191 and MK2206 repressed EGFR expression. Furthermore, indoxyl sulfate increased the sensitivity of CRC cells to EGF by upregulating EGFR expression. These findings suggest that i...
Source: Biomed Res - March 31, 2024 Category: Research Authors: Yu Ichisaka Shozo Yano Kohji Nishimura Toshimitsu Niwa Hidehisa Shimizu Source Type: research
Tenascin-X is increased with decreased expression of miR-378a-5p and miR-486-5p in mice fed a methionine-choline-deficient diet that induces hepatic fibrosis
In this study, we investigated Tnxb expression in livers with fibrosis caused by administration of a methionine-chorine-deficient (MCD) diet in mice. Whole transcriptome analysis showed that Tnxb was one of the genes with increased expression in livers of MCD diet-fed mice compared with that in livers of normal diet (ND)-fed mice. In microarray and subsequent microRNA (miRNA) network analyses, miR-378a-5p and miR-486-5p were identified in livers of MCD diet-fed mice as downregulated miRNAs, which have their predicted target sites in the 3' untranslated region of Tnxb mRNA and might suppress the translation of Tnxb mRNA. RT...
Source: Biomed Res - March 31, 2024 Category: Research Authors: Ken-Ichi Matsumoto Takuma Higuchi Mirei Umeki Masafumi Ono Shuji Sakamoto Source Type: research
Distribution and anti-nociceptive function of endomorphin-1 in the rat cranial sensory ganglia
Biomed Res. 2024;45(2):77-89. doi: 10.2220/biomedres.45.77.ABSTRACTDistribution of endomorphin-1 (EM-1) was immunohistochemically investigated in the rat cranial sensory ganglia. Small to medium-sized neurons in the trigeminal (TG), petrosal (PG), and jugular ganglia (JG) expressed EM-1-immunoreactivity. However, EM-1-immunoreactive (-ir) neurons were infrequent in the nodose ganglion. In the brainstem, EM-1-ir varicose fibers were detected in the superficial layer of the medullary dorsal horn and the caudal part of the nucleus tractus solitarius. By trichrome immunofluorescence analysis, approximately 70% of EM-1-ir neuro...
Source: Biomed Res - March 31, 2024 Category: Research Authors: Shun Sato Tadasu Sato Takehiro Yajima Daisuke Tachiya Tetsu Takahashi Shinnosuke Nogami Masahiro Saito Kensuke Yamauchi Hiroyuki Ichikawa Source Type: research
