The clinical use of bone graft substitutes in orthopedic surgery in Germany-A 10-years survey from 2008 to 2018 of 1,090,167 surgical interventions
J Biomed Mater Res B Appl Biomater. 2021 Jul 22. doi: 10.1002/jbm.b.34911. Online ahead of print.ABSTRACTAim of the study was to evaluate (1) the overall use of bone graft substitutes, autografts and allografts, (2) of different types of bone graft substitutes (calcium sulfate, calcium phosphate, calcium phosphate ceramics or polymethyl methacrylate) and of different bone grafts (cancellous vs. cortical), and (3) the use of antibiotic-loading of bone graft substitutes in orthopedic surgery in Germany. Gross data were provided from the Federal Statistical Office of Germany and revealed an overall increase in bone defect rec...
Source: Biomed Res - July 22, 2021 Category: Research Authors: Markus Rupp Lisa Klute Susanne Baertl Nike Walter Gopala-Krishna Mannala Leona Frank Christian Pfeifer Volker Alt Maximilian Kerschbaum Source Type: research

Oridonin Promotes Apoptosis and Restrains the Viability and Migration of Bladder Cancer by Impeding TRPM7 Expression via the ERK and AKT Signaling Pathways
CONCLUSION: Oridonin exhibited outstanding antiproliferative and antimigratory effects on bladder cancer, and these effects were at least partially associated with targeting of TRPM7 through inactivation of the ERK and AKT signaling pathways. These findings provide insight for the clinical application of oridonin in bladder cancer prevention.PMID:34285910 | PMC:PMC8275389 | DOI:10.1155/2021/4340950 (Source: Biomed Res)
Source: Biomed Res - July 21, 2021 Category: Research Authors: Xianping Che Jiangtao Zhan Fan Zhao Zunhe Zhong Mianchuan Chen Ruifa Han Yi Wang Source Type: research

Intraoperative Blood Loss and Postoperative Pain in the Sagittal Split Ramus Osteotomy and Intraoral Vertical Ramus Osteotomy: A Literature Review
CONCLUSION: Compared to traditional SSRO, IVRO had a significantly lower amount of blood loss. However, the blood transfusion is not necessary in a single-jaw operation (SSRO or IVRO). Postoperative pain was similar between SSRO and IVRO.PMID:34285911 | PMC:PMC8275401 | DOI:10.1155/2021/4439867 (Source: Biomed Res)
Source: Biomed Res - July 21, 2021 Category: Research Authors: Kun-Tsung Lee Shiu-Shiung Lin Kun-Jung Hsu Chi-Yu Tsai Yi-Hao Lee Yu-Jen Chang Te-Ju Wu Source Type: research

Comprehensive Profile Analysis of Differentially Expressed circRNAs in Glucose Deprivation-Induced Human Nucleus Pulposus Cell Degeneration
In this study, the differentially expressed circRNAs in NP cells after 0, 6, 12, and 24 h of glucose deprivation culture were detected by a microarray assay. Besides, time series clustering analysis by STEM software obtained the differentially up- and downregulated circRNAs during glucose deficiency. Then, the main functions and pathways of up- and downregulated circRNAs were predicted by the functional enrichment analysis. By constructing the circRNA-miRNA regulatory network, the potential mechanisms of the most differentially expressed circRNAs were predicted. In addition, according to in vitro validation, circ_0075062 w...
Source: Biomed Res - July 21, 2021 Category: Research Authors: Hongze Chang Hongzhang Wang Xiaolong Yang Kemin You Mingwei Jiang Feng Cai Yan Zhang Liang Liu Hui Liu Xiaodong Liu Source Type: research

Lineage Contribution of PDGFR < em > α < /em > -Expressing Cells in the Developing Mouse Eye
In this study, we aim to present a detailed PDGFRα expression and lineage map from early embryogenesis to adulthood. PDGFRα-CreER; mT/mG reporter mice were analyzed. mEGFP-positive cells contributed to multiple ocular lineages in a spatiotemporally regulated manner. A dynamic PDGFRα expression was identified in corneal stromal cells, lens epithelial cells, lens fiber cells, and retinal astrocytes during the entire period of eye development, while PDGFRα expression in retinal astrocytes from E17.5 onwards and in Müller glial cells was identified within two weeks after birth. By revealing detaile...
Source: Biomed Res - July 21, 2021 Category: Research Authors: Deyi Zhuo Yumei Diao Xiaoqi Li Yifei Huang Liqiang Wang Source Type: research

Identification and Validation of Potential Biomarkers and Pathways for Idiopathic Pulmonary Fibrosis by Comprehensive Bioinformatics Analysis
CONCLUSION: Our study identified several IPF-related DEGs that could become potential biomarkers for IPF. Large-scale multicentric studies are eagerly needed to confirm the utility of these biomarkers.PMID:34285914 | PMC:PMC8275392 | DOI:10.1155/2021/5545312 (Source: Biomed Res)
Source: Biomed Res - July 21, 2021 Category: Research Authors: Weibin Qian Xinrui Cai Qiuhai Qian Xinying Zhang Source Type: research

The Potential Benefits of Nanotechnology in Treating Alzheimer's Disease
Biomed Res Int. 2021 Jul 4;2021:5550938. doi: 10.1155/2021/5550938. eCollection 2021.ABSTRACTAlzheimer's disease is a neurodegenerative disorder that is caused by the accumulation of beta-amyloid plaques in the brain. Currently, there is no definitive cure available to treat Alzheimer's disease. The available medication in the market has the ability to only slow down its progression. However, nanotechnology has shown its superiority that can be applied for medical usage and it has a great potential in the therapy of Alzheimer's disease, specifically in the disease diagnosis and providing an alternative approach to treat Al...
Source: Biomed Res - July 21, 2021 Category: Research Authors: Tan Sook Ling Shanthini Chandrasegaran Low Zhi Xuan Tong Li Suan Elaine Elaine Durrgashini Visva Nathan Yam Hok Chai Baskaran Gunasekaran Shamala Salvamani Source Type: research

Combining Well-Tempered Metadynamics Simulation and SPR Assays to Characterize the Binding Mechanism of the Universal T-Lymphocyte Tetanus Toxin Epitope TT830-843
Biomed Res Int. 2021 Jul 4;2021:5568980. doi: 10.1155/2021/5568980. eCollection 2021.ABSTRACTPeptide TT830-843 from the tetanus toxin is a universal T-cell epitope. It helps in vaccination and induces T-cell activation. However, the fine molecular interaction between this antigen and the major histocompatibility complex (MHC) remains unknown. Molecular analysis of its interaction with murine MHC (H-2) was proposed to explore its immune response efficiency. Molecular dynamics simulations are important mechanisms for understanding the basis of protein-ligand interactions, and metadynamics is a useful technique for enhancing ...
Source: Biomed Res - July 21, 2021 Category: Research Authors: Artur A M L Brandt Rodrigo N Rodrigues-da-Silva Josu é C Lima-Junior Carlos R Alves Franklin de Souza-Silva Source Type: research

A Comparative Study of the Effects of Valproate and Oxcarbazepine on Sexual Function, Sperm Quality, and Sex Hormones in Males with Epilepsy
CONCLUSION: Sexual function and sperm quality were reduced in young males with epilepsy. VPA may exert a negative effect on sperm quality, whereas OXC has no harmful effect on sexual function and sperm quality in young males with epilepsy.PMID:34285917 | PMC:PMC8275390 | DOI:10.1155/2021/6624101 (Source: Biomed Res)
Source: Biomed Res - July 21, 2021 Category: Research Authors: Yi Guo Lang Chen Dongmei Wu Liang Yu Hongbin Sun Qiong Zhu Source Type: research

An Ultrastructural Study on the Effect of High Temperatures on Teeth and Restorative Materials That Aids in the Identification of Human Remains
CONCLUSION: Elemental analysis of the specific restorative material proves to be an essential tool for the forensic odontologist.PMID:34285918 | PMC:PMC8275398 | DOI:10.1155/2021/6629560 (Source: Biomed Res)
Source: Biomed Res - July 21, 2021 Category: Research Authors: V Yashoda Manay Srinivas Munisekhar S Shylaja Krishna A Rao Sharath Kumar Reddy Farahnaz Muddebihal Mohammad Khursheed Alam Source Type: research

< em > FCGR2A < /em > Could Function as a Prognostic Marker and Correlate with Immune Infiltration in Head and Neck Squamous Cell Carcinoma
Biomed Res Int. 2021 Jul 5;2021:8874578. doi: 10.1155/2021/8874578. eCollection 2021.ABSTRACTOBJECTIVE: We aim to investigate the correlation between FCGR2A mRNA level and prognosis of head and neck squamous cancer (HNSC) in public databases. In addition, we investigated the correlation between FCGR2A expression and clinicopathological characteristics and tumor-infiltrating immune cells in HNSC patients.METHODS: FCGR2A mRNA expression in multiple cancers was analyzed based on Gene Expression Profiling Interactive Analysis. A protein-protein interaction network was obtained based on the STRING database. The 10 proteins most...
Source: Biomed Res - July 21, 2021 Category: Research Authors: Yongmei Dai Wenhan Chen Junpeng Huang Tongjian Cui Source Type: research

Development, Characterization, and Evaluation of SLN-Loaded Thermoresponsive Hydrogel System of Topotecan as Biological Macromolecule for Colorectal Delivery
CONCLUSION: It can be concluded that SLNs incorporated in TRHS could be a potential source of the antitumour drug delivery with better control of the drug release and no toxicity.PMID:34285920 | PMC:PMC8275402 | DOI:10.1155/2021/9968602 (Source: Biomed Res)
Source: Biomed Res - July 21, 2021 Category: Research Authors: R Xing O Mustapha T Ali M Rehman S S Zaidi A Baseer S Batool M Mukhtiar S Shafique M Malik S Sohail Z Ali F Zahid A Zeb F Shah A Yousaf F Din Source Type: research

Tranexamic acid-loaded hemostatic nanoclay microsphere frameworks
J Biomed Mater Res B Appl Biomater. 2021 Jul 21. doi: 10.1002/jbm.b.34918. Online ahead of print.ABSTRACTFast acting topical hemostatic agents play a key role in hemorrhage control. Retarding fibrinolysis is also critical in improving coagulation, thereby expanding chances of survival. The purpose of the present work was to investigate the physical properties, loading capacity and hemostatic efficacy of newly developed nanoclay microsphere frameworks (NMFs) loaded with tranexamic acid (TA), as antifibrinolytic agent. Nanoclay compositions were prepared with increasing levels of TA. Results showed that TA was successfully i...
Source: Biomed Res - July 21, 2021 Category: Research Authors: Isabelle Denry Jean-Marie N édélec Julie A Holloway Source Type: research

Enhanced water and oxygen barrier performance of flexible polyurethane membranes for biomedical application
J Biomed Mater Res A. 2021 Jul 20. doi: 10.1002/jbm.a.37269. Online ahead of print.ABSTRACTIn order to improve water and oxygen barrier properties, the surface of two commercial medical grade polyurethane (PU) membranes (Chronoflex® AR-LT and Bionate® II) was modified by a spray deposited film of poly(ethylene-co-vinyl alcohol) (EVOH). The influence of the temperature, the deposited layer thickness and the EVOH ethylene group percentage (27%, 32%, and 44% for EVOH27, EVOH32, and EVOH44, respectively) on the barrier properties of the PU/EVOH multilayered membranes was investigated. The increase of the EVOH layer thi...
Source: Biomed Res - July 21, 2021 Category: Research Authors: Aracelys Marcano Kateryna Fatyeyeva Malys Koun Pascal Dubuis Marc Grimme Corinne Chappey St éphane Marais Source Type: research

Controlled release of the drug for osteoporosis from the surface of titanium implants coated with calcium titanate
J Biomed Mater Res B Appl Biomater. 2021 Jul 21. doi: 10.1002/jbm.b.34919. Online ahead of print.ABSTRACTThe most popular drugs used to prevent osteoporosis that causes low mineral density and weakened microstructure of bones are bisphosphonates. Bisphosphonates can be administered in several ways, but each delivery method has drawbacks. Due to this, new methods of their delivery are being sought. Titanium implants coated with calcium titanate were prepared in this work as carriers for bisphosphonates. Such a modification has been proposed in order to improve the therapeutic properties of the implant. Slow release of the d...
Source: Biomed Res - July 21, 2021 Category: Research Authors: Mariusz Sandomierski Monika Zieli ńska Tomasz Buchwald Adam Patalas Adam Voelkel Source Type: research

Microfluidic fabrication of imageable and resorbable polyethylene glycol microspheres for catheter embolization
J Biomed Mater Res A. 2021 Jul 21. doi: 10.1002/jbm.a.37271. Online ahead of print.ABSTRACTRadiopaque and degradable hydrogel microspheres have a range of potential uses in medicine including proper placement of embolic material during occlusion procedures, acting as inherently embolic materials, and serving as drug carriers that can be located after injection. Current methods for creating radiopaque microspheres are either unable to fully and homogeneously incorporate radiopaque material throughout the microspheres for optimal imaging capabilities, do not result in degradable or fully compressible microspheres, or require...
Source: Biomed Res - July 21, 2021 Category: Research Authors: Kyle Vogt Lavanya Aryan Samuel Stealey Andrew Hall Kieth Pereira Silviya P Zustiak Source Type: research

Nano/micro implant debris affect osteogenesis by chondrocytes: Comparison between ceramic and UHMWPE from hip walking simulator
J Biomed Mater Res B Appl Biomater. 2021 Jul 21. doi: 10.1002/jbm.b.34910. Online ahead of print.ABSTRACTA new generation of ceramic on ceramic (BIOLOX ®delta) bearings has emerged more than 10 years ago proving a high resistance to wear and good clinical results. However, biological reactions to wear debris, particularly the nanoparticles, need to be evaluated. The first originality of this study is to start from real wear particles obtained by the hip walking simulator (CERsim). These particles were compared with particles obtained by usual methods to assess the biocompatibility of materials: press machine (CERpress)...
Source: Biomed Res - July 21, 2021 Category: Research Authors: Marwa Ben Braham Ana Maria Trunfio-Sfarghiu Leyre Brizuela Saida Mebarek Ines Essefi Jean Geringer Yves Berthier Samir Hamza Source Type: research

Enhanced culturing of adipose derived mesenchymal stem cells on surface modified polystyrene Petri dishes fabricated by plasma enhanced chemical vapor deposition system
J Biomed Mater Res B Appl Biomater. 2021 Jul 21. doi: 10.1002/jbm.b.34912. Online ahead of print.ABSTRACTMesenchymal stem cells (MSCs) have received considerable attention as therapeutic cells for regenerative medicine and tissue engineering, because of their ability to replace damaged cells or regenerate surrounding cells. There are many technical difficulties in the mass production of high-quality stem cells because the stem cells must maintain an efficient proliferative cell state during in vitro culture. The results of this study show that plasma surface-modification enhanced significantly the culture of adipose-derive...
Source: Biomed Res - July 21, 2021 Category: Research Authors: Hyuna Lim Yoonsoo Park Sujeong Jang Heonyong Park Yong Ki Cho Donggeun Jung Source Type: research

Influence of enantiomeric polylysine grafted on gold nanorods on the uptake and inflammatory response of bone marrow-derived macrophages in vitro
In this study, the enantiomeric poly-D-lysine (PDL) and poly-L-lysine (PLL) were conjugated to gold nanorods (AuNRs) to study their influence on the polarization of macrophages. The AuNRs capped with cetyl trimethyl ammonium bromide (CTAB) (AuNRs@CTAB) exhibited larger toxicity to macrophages when their concentration was higher than 50 μg/ml, whereas the AuNRs@PDL and AuNRs@PLL showed neglectable toxicity at the same concentration compared with the control. The AuNRs@PDL and AuNRs@PLL were internalized into the macrophages with a higher value than the AuNRs@CTAB as revealed by transmission electron microscopy (TEM) and ...
Source: Biomed Res - July 21, 2021 Category: Research Authors: Wajiha Ahmed Haolan Zhang Changyou Gao Source Type: research

EPR spectroscopy of whole blood and blood components: can we diagnose abnormalities?
J Biomed Res. 2021 Apr 30;35(4):295-301. doi: 10.7555/JBR.35.20210011.ABSTRACTThis mini-review gives a brief account of the emergence of the electron paramagnetic resonance (EPR) spectroscopy in the second half of the 20 th century and reports the continuous wave EPR spectroscopy studies on human and animal blood. The question posed by this review is whether the EPR spectroscopy in the form it appeared 70 years ago is still able to provide useful information about different pathological conditions in humans, particularly in the area of diagnosis.PMID:34282059 | DOI:10.7555/JBR.35.20210011 (Source: Biomed Res)
Source: Biomed Res - July 20, 2021 Category: Research Authors: Dimitri A Svistunenko Source Type: research

EPR spectroscopy of whole blood and blood components: can we diagnose abnormalities?
J Biomed Res. 2021 Apr 30:295-301. doi: 10.7555/JBR.35.20210011. Online ahead of print.ABSTRACTThis mini-review gives a brief account of the emergence of the electron paramagnetic resonance (EPR) spectroscopy in the second half of the 20 th century and reports the continuous wave of EPR spectroscopy studies on human and animal blood. The question posed by this review is whether the EPR spectroscopy in the form it appeared 70 years ago is still able to provide useful information about different pathological conditions in humans, particularly in the area of diagnosis.PMID:34282059 | DOI:10.7555/JBR.35.20210011 (Source: Biomed Res)
Source: Biomed Res - July 20, 2021 Category: Research Authors: Dimitri A Svistunenko Source Type: research

Laser surface treatment on Yttria-stabilized zirconia dental implants: Influence on cell behavior
J Biomed Mater Res B Appl Biomater. 2021 Jul 18. doi: 10.1002/jbm.b.34909. Online ahead of print.ABSTRACTYttria-stabilized zirconia (YSZ) is being proposed as an alternative material to Titanium for dental implants due to its aesthetic and biocompatibility properties. However, is it yet to define the optimal surface treatment to improve YSZ bioactivy. Texturization is a promising approach, but the biological role of patterned YSZ surfaces in cell cultures is yet to be determined. Thus, cellular behavior of osteoblasts and fibroblasts in contact with groove-texturized YSZ surfaces was investigated. YSZ discs were groove-tex...
Source: Biomed Res - July 19, 2021 Category: Research Authors: Mariana Brito da Cruz Joana Faria Marques Beatriz Ferreira Fernandes Paulo Pinto Sara Madeira Óscar Carvalho Filipe Samuel Silva Jo ão Manuel Mendez Caramês Ant ónio Duarte Sola Pereira da Mata Source Type: research

Laser surface treatment on Yttria-stabilized zirconia dental implants: Influence on cell behavior
J Biomed Mater Res B Appl Biomater. 2021 Jul 18. doi: 10.1002/jbm.b.34909. Online ahead of print.ABSTRACTYttria-stabilized zirconia (YSZ) is being proposed as an alternative material to Titanium for dental implants due to its aesthetic and biocompatibility properties. However, is it yet to define the optimal surface treatment to improve YSZ bioactivy. Texturization is a promising approach, but the biological role of patterned YSZ surfaces in cell cultures is yet to be determined. Thus, cellular behavior of osteoblasts and fibroblasts in contact with groove-texturized YSZ surfaces was investigated. YSZ discs were groove-tex...
Source: Biomed Res - July 19, 2021 Category: Research Authors: Mariana Brito da Cruz Joana Faria Marques Beatriz Ferreira Fernandes Paulo Pinto Sara Madeira Óscar Carvalho Filipe Samuel Silva Jo ão Manuel Mendez Caramês Ant ónio Duarte Sola Pereira da Mata Source Type: research

A systematic review on the effect of inorganic surface coatings in large animal models and meta-analysis on tricalcium phosphate and hydroxyapatite on periimplant bone formation
J Biomed Mater Res B Appl Biomater. 2021 Jul 16. doi: 10.1002/jbm.b.34899. Online ahead of print.ABSTRACTThe aim of the present systematic review was to analyse studies using inorganic implant coatings and, in a meta-analysis, the effect of specifically tricalcium phosphate (TCP) and hydroxyapatite (HA) implant surface coatings on bone formation according to the PRISMA criteria. Inclusion criteria were the comparison to rough surfaced titanium implants in large animal studies at different time points of healing. Forty studies met the inclusion criteria for the systematic review. Fifteen of these analyzed the bone-to-implan...
Source: Biomed Res - July 17, 2021 Category: Research Authors: Jeanne-Marie Damerau Susanne Bierbaum Daniel Wiedemeier Paula Korn Ralf Smeets Gregor Jenny Johanna Nadalini Bernd Stadlinger Source Type: research

A systematic review on the effect of inorganic surface coatings in large animal models and meta-analysis on tricalcium phosphate and hydroxyapatite on periimplant bone formation
J Biomed Mater Res B Appl Biomater. 2021 Jul 16. doi: 10.1002/jbm.b.34899. Online ahead of print.ABSTRACTThe aim of the present systematic review was to analyse studies using inorganic implant coatings and, in a meta-analysis, the effect of specifically tricalcium phosphate (TCP) and hydroxyapatite (HA) implant surface coatings on bone formation according to the PRISMA criteria. Inclusion criteria were the comparison to rough surfaced titanium implants in large animal studies at different time points of healing. Forty studies met the inclusion criteria for the systematic review. Fifteen of these analyzed the bone-to-implan...
Source: Biomed Res - July 17, 2021 Category: Research Authors: Jeanne-Marie Damerau Susanne Bierbaum Daniel Wiedemeier Paula Korn Ralf Smeets Gregor Jenny Johanna Nadalini Bernd Stadlinger Source Type: research

Cytocompatibility of a mussel-inspired poly(lactic acid)-based adhesive
J Biomed Mater Res A. 2021 Jul 14. doi: 10.1002/jbm.a.37264. Online ahead of print.ABSTRACTIncorporating catechols into polymers can provide strong adhesion even in moist environments, and these polymers show promise for use in several biomedical applications. Surgical adhesives must have strong bonds, be biocompatible, and function in a moist environment. Poly(lactic acid) (PLA) has a long history as a biocompatible material for hard tissue device fixation. By combining these concepts, catechol-containing poly(lactic acid) (cPLA) polymers are created that are strongly adhesive and degrade in physiological environments. He...
Source: Biomed Res - July 15, 2021 Category: Research Authors: Sydney Hollingshead Heather Siebert Jonathan J Wilker Julie C Liu Source Type: research

Hybrid adipose graft materials synthesized from chemically modified adipose extracellular matrix
In this study, we have integrated the decellularized thiolated adipose-derived ECM, at different concentrations, with polyethylene glycol (PEG) using Michael addition between thiol and acrylate moieties. The potential for this material to support adipogenic differentiation of human adipose-derived stem cells was evaluated by encapsulating cells in hydrogels with increasing concentrations of chemically modified ECM (mECM). Our results demonstrated a positive correlation between the ECM content in the hydrogels and cell proliferation, adipogenic marker expression, and lipid formation and accumulation. Furthermore, we have sh...
Source: Biomed Res - July 15, 2021 Category: Research Authors: Shue Li Yiming Liu Jacob McCann Dino J Ravnic Jeffrey M Gimble Daniel J Hayes Source Type: research

Cytocompatibility of a mussel-inspired poly(lactic acid)-based adhesive
J Biomed Mater Res A. 2021 Jul 14. doi: 10.1002/jbm.a.37264. Online ahead of print.ABSTRACTIncorporating catechols into polymers can provide strong adhesion even in moist environments, and these polymers show promise for use in several biomedical applications. Surgical adhesives must have strong bonds, be biocompatible, and function in a moist environment. Poly(lactic acid) (PLA) has a long history as a biocompatible material for hard tissue device fixation. By combining these concepts, catechol-containing poly(lactic acid) (cPLA) polymers are created that are strongly adhesive and degrade in physiological environments. He...
Source: Biomed Res - July 15, 2021 Category: Research Authors: Sydney Hollingshead Heather Siebert Jonathan J Wilker Julie C Liu Source Type: research

Hybrid adipose graft materials synthesized from chemically modified adipose extracellular matrix
In this study, we have integrated the decellularized thiolated adipose-derived ECM, at different concentrations, with polyethylene glycol (PEG) using Michael addition between thiol and acrylate moieties. The potential for this material to support adipogenic differentiation of human adipose-derived stem cells was evaluated by encapsulating cells in hydrogels with increasing concentrations of chemically modified ECM (mECM). Our results demonstrated a positive correlation between the ECM content in the hydrogels and cell proliferation, adipogenic marker expression, and lipid formation and accumulation. Furthermore, we have sh...
Source: Biomed Res - July 15, 2021 Category: Research Authors: Shue Li Yiming Liu Jacob McCann Dino J Ravnic Jeffrey M Gimble Daniel J Hayes Source Type: research

Vessel Density and Structural Measurements in Primary Angle-Closure Suspect Glaucoma Using Optical Coherence Tomography Angiography
CONCLUSIONS: OCTA showed significant thicker change on RNFL in the PACS group. Only OPP was independently associated with RNFL in the PACS group.PMID:34258258 | PMC:PMC8243897 | DOI:10.1155/2020/7526185 (Source: Biomed Res)
Source: Biomed Res - July 14, 2021 Category: Research Authors: Yi Zha Juanjuan Chen Shuyu Liu Jinfei Zhuang Jianqiu Cai Source Type: research

Whole-Genome Sequence Data Analysis of < em > Anoxybacillus kamchatkensis < /em > NASTPD13 Isolated from Hot Spring of Myagdi, Nepal
Biomed Res Int. 2021 Jun 27;2021:1869748. doi: 10.1155/2021/1869748. eCollection 2021.ABSTRACTAnoxybacillus kamchatkensis NASTPD13 isolated from Paudwar hot spring of Myagdi, Nepal, upon morphological and biochemical analysis revealed to be Gram-positive, straight or slightly curved, rod-shaped, spore-forming, catalase, and oxidase-positive facultative anaerobes. It grows over a wide range of pH (5.0-11) and temperature (37-75°C), which showed growth in different reduced carbon sources such as starch raffinose, glucose, fructose, inositol, trehalose, sorbitol, mellobiose, and mannitol in aerobic conditions. Furthermore...
Source: Biomed Res - July 14, 2021 Category: Research Authors: Punam Yadav Shikha Sharma Tribikram Bhattarai Lakshmaiah Sreerama Gandham S Prasad Girish Sahni Jyoti Maharjan Source Type: research

Exploring the Operative Strategy for Secondary Mitral Regurgitation: A Systematic Review
CONCLUSION: There is currently no unanimous and shared strategy for the optimal treatment of patients with secondary IMR. The management of patients with secondary mitral regurgitation must be entrusted to a multidisciplinary Heart Team to ensure ideal intervention and patient matching for the best outcomes.PMID:34258260 | PMC:PMC8245239 | DOI:10.1155/2021/3466813 (Source: Biomed Res)
Source: Biomed Res - July 14, 2021 Category: Research Authors: Francesco Nappi Sanjeet Singh Avtaar Singh Francesca Bellomo Pierluigi Nappi Camilla Chello Adelaide Iervolino Massimo Chello Source Type: research

CYP2J2 Is a Diagnostic and Prognostic Biomarker Associated with Immune Infiltration in Kidney Renal Clear Cell Carcinoma
In this study, expression levels of CYP2J2 in various cancer types were determined using the Oncomine, the Gene Expression Profiling Interactive Analysis (GEIPA), DriverDBv3, UALCAN, and Tumor Immune Estimation Resource (TIMER) databases. The prognostic value of CYP2J2 for KIRC was analyzed using GEPIA, UALCAN, OSkirc, and DriverDBv3 databases. We evaluated the expression levels of CYP2J2 transcript, protein, and promoter methylation at different clinical characteristics in KIRC through the UALCAN database. Simultaneously, CYP2J2 network-related functions were evaluated using the GeneMANIA interactive tool while the biolog...
Source: Biomed Res - July 14, 2021 Category: Research Authors: Xiong Zou Zengnan Mo Source Type: research

Whole Volume Apparent Diffusion Coefficient (ADC) Histogram as a Quantitative Imaging Biomarker to Differentiate Breast Lesions: Correlation with the Ki-67 Proliferation Index
Biomed Res Int. 2021 Jun 24;2021:4970265. doi: 10.1155/2021/4970265. eCollection 2021.ABSTRACTOBJECTIVES: To evaluate the value of the whole volume apparent diffusion coefficient (ADC) histogram in distinguishing between benign and malignant breast lesions and differentiating different molecular subtypes of breast cancers and to assess the correlation between ADC histogram parameters and Ki-67 expression in breast cancers.METHODS: The institutional review board approved this retrospective study. Between September 2016 and February 2019, 189 patients with 84 benign lesions and 105 breast cancers underwent magnetic resonance...
Source: Biomed Res - July 14, 2021 Category: Research Authors: Yuan Guo Qing-Cong Kong Li-Qi Li Wen-Jie Tang Wan-Li Zhang Guan-Yuan Ning Jun Xue Qian-Wei Zhou Ying-Ying Liang Mei Wu Xin-Qing Jiang Source Type: research

PLOD2 Is a Potent Prognostic Marker and Associates with Immune Infiltration in Cervical Cancer
Biomed Res Int. 2021 Jun 28;2021:5512340. doi: 10.1155/2021/5512340. eCollection 2021.ABSTRACTBACKGROUND: PLOD2 is overexpressed in diverse tumors and plays a vital role in tumorigenesis. However, the prognostic value of PLOD2 in cervical cancer (CESC) remains unclear.METHODS: PLOD2 expression and CESC patients' survival data were collected from the Oncomine, GEPIA, UALCAN, and Kaplan-Meier Plotter databases; immunohistochemistry (IHC) was used to validate the expression of PLOD2 in CESC; Gene Set Enrichment Analysis was performed using the STRING and DAVID databases; and the correlations between PLOD2 and cancer immune in...
Source: Biomed Res - July 14, 2021 Category: Research Authors: Guang Li Xuefeng Wang Guobing Liu Source Type: research

The Effect of Combined Oral Contraceptive Pills on Beclin-1 and LC3B Transcript Levels in Ovarian Endometrioma
CONCLUSIONS: Oral COC pills for 6 weeks continuously before surgery decreased the eutopic endometrial expression (mRNA) of the BECN1 gene compared to those from healthy normal women and nontreated patients with an endometriotic cyst. The change in the expression of autophagy-related genes was more distinct in eutopic than ectopic endometria. This trial is registered with TCTR20170720002. Registered and enrolled the first patient on 20 July 2017.PMID:34258264 | PMC:PMC8260293 | DOI:10.1155/2021/5519538 (Source: Biomed Res)
Source: Biomed Res - July 14, 2021 Category: Research Authors: Wanwisa Waiyaput Ongarj Bovornsakulvong Srithean Lertvikool Areepan Sophonsritsuk Source Type: research

Cytoreductive Surgery plus Hyperthermic Intraperitoneal Chemotherapy Improves Survival with Acceptable Safety for Advanced Ovarian Cancer: A Clinical Study of 100 Patients
This study is aimed at evaluating the efficacy and safety of cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy (CRS+HIPEC) as first-line surgical treatment in patients with advanced ovarian cancer (AOC).METHODS: FIGO stage III/IV AOC patients underwent CRS+HIPEC as first-line surgical treatment at our center from December 2007 to January 2020. The primary endpoint was survival, and the secondary endpoint was safety.RESULTS: Among 100 patients, the median Karnofsky performance status (KPS) score was 80 (50-100), median peritoneal cancer index (PCI) was 19 (1-39), median completeness of cytoreduction (CC) ...
Source: Biomed Res - July 14, 2021 Category: Research Authors: Jue Zhang Xin-Bao Li Zhong-He Ji Ru Ma Wen-Pei Bai Yan Li Source Type: research

Herbal Active Ingredients: Potential for the Prevention and Treatment of Acute Lung Injury
Biomed Res Int. 2021 Jun 22;2021:5543185. doi: 10.1155/2021/5543185. eCollection 2021.ABSTRACTAcute lung injury (ALI) is a life-threatening clinical syndrome with high morbidity and mortality. The main pathological features of ALI are increased alveolar-capillary membrane permeability, edema, uncontrolled migration of neutrophils to the lungs, and diffuse alveolar damage, resulting in acute hypoxemic respiratory failure. Glucocorticoids, aspirin, and other anti-inflammatory drugs are commonly used to treat ALI. Respiratory supports, such as a ventilator, are used to alleviate hypoxemia. Many treatment methods are available...
Source: Biomed Res - July 14, 2021 Category: Research Authors: Wen-Ying Yu Chun-Xiao Gao Huan-Huan Zhang Yue-Guo Wu Chen-Huan Yu Source Type: research

Relevant SARS-CoV-2 Genome Variation through Six Months of Worldwide Monitoring
In this study, we present an accurate method for temporal and geographical comparison of mutational events based on GISAID database genome sequencing. Among 42523 SARS-CoV-2 genomes analyzed, we found 23202 variants compared to the reference genome. The Ti/Tv (transition/transversion) ratio was used to filter out possible false-positive errors. Transition mutations generally occurred more frequently than transversions. Our clustering analysis revealed remarkable hotspot mutation patterns for SARS-CoV-2. Mutations were clustered based on how their frequencies changed over time according to each geographical location. We obs...
Source: Biomed Res - July 14, 2021 Category: Research Authors: Abdelmalek Hakmaoui Faisal Khan Abdelhamid Liacini Amanjot Kaur Yacine Berka Safaa Machraoui Hafid Soualhine Noureddine Berka Hanane Rais Brahim Admou Source Type: research

Patient Recovery from COVID-19 Infections: Follow-Up of Hair, Nail, and Cutaneous Manifestations
CONCLUSIONS: Cutaneous manifestations, hair disorders, and nail abnormalities can occur in patients with COVID-19 after their discharge from hospital. Patients should therefore be followed up in anticipation of dermatological problems.PMID:34258268 | PMC:PMC8238562 | DOI:10.1155/2021/5595016 (Source: Biomed Res)
Source: Biomed Res - July 14, 2021 Category: Research Authors: Rattapon Thuangtong Nasikarn Angkasekwinai Charussri Leeyaphan Daranporn Triwongwaranat Kanchalit Thanomkitti Kanyalak Munprom Kanokvalai Kulthanan Source Type: research

An Extended Approach to Predict Retinopathy in Diabetic Patients Using the Genetic Algorithm and Fuzzy C-Means
Biomed Res Int. 2021 Jun 26;2021:5597222. doi: 10.1155/2021/5597222. eCollection 2021.ABSTRACTThe present study is developed a new approach using a computer diagnostic method to diagnosing diabetic diseases with the use of fluorescein images. In doing so, this study presented the growth region algorithm for the aim of diagnosing diabetes, considering the angiography images of the patients' eyes. In addition, this study integrated two methods, including fuzzy C-means (FCM) and genetic algorithm (GA) to predict the retinopathy in diabetic patients from angiography images. The developed algorithm was applied to a total of 224...
Source: Biomed Res - July 14, 2021 Category: Research Authors: Saeid Jafarzadeh Ghoushchi Ramin Ranjbarzadeh Amir Hussein Dadkhah Yaghoub Pourasad Malika Bendechache Source Type: research

N-Acetylcysteine Improves Inflammatory Response in COPD Patients by Regulating Th17/Treg Balance through Hypoxia Inducible Factor-1 < em > α < /em > Pathway
CONCLUSIONS: Our result could provide new diagnosis and treatment for elderly patients with COPD from the perspective of immunity ideas.PMID:34258270 | PMC:PMC8260296 | DOI:10.1155/2021/6372128 (Source: Biomed Res)
Source: Biomed Res - July 14, 2021 Category: Research Authors: Xiaopeng Liu Zhixiong Hu Haiying Zhou Source Type: research

Body Mass Index Is Associated with the Severity and All-Cause Mortality of Acute Kidney Injury in Critically Ill Patients: An Analysis of a Large Critical Care Database
CONCLUSIONS: BMI was independently associated with the severity and all-cause mortality of AKI in critical illness. Overweight and obesity were associated with increased risk of AKI stage III; however, they were predictive of a relatively lower mortality risk in these patients.PMID:34258271 | PMC:PMC8260311 | DOI:10.1155/2021/6616120 (Source: Biomed Res)
Source: Biomed Res - July 14, 2021 Category: Research Authors: Benji Wang Diwen Li Yuqiang Gong Binyu Ying Bihuan Cheng Laifang Sun Source Type: research

Early Detection of Radiation-Induced Injury and Prediction of Cognitive Deficit by MRS Metabolites in Radiotherapy of Low-Grade Glioma
CONCLUSION: MRS-based biomarkers may be more sensitive than the state-of-the-art cognitive tests in the prediction of postradiation cognitive impairments. They would be utilized in treatment planning and dose sparing protocols, with a specific focus on the corpus callosum in the radiation therapy of LGG patients.PMID:34258272 | PMC:PMC8260313 | DOI:10.1155/2021/6616992 (Source: Biomed Res)
Source: Biomed Res - July 14, 2021 Category: Research Authors: Zahra Alirezaei Alireza Amouheidari Masoud Hassanpour Fariba Davanian Sajjad Iraji Parvaneh Shokrani Mohammad-Reza Nazem-Zadeh Source Type: research

Missense Variant of Endoplasmic Reticulum Region of < em > WFS1 < /em > Gene Causes Autosomal Dominant Hearing Loss without Syndromic Phenotype
CONCLUSIONS: In this family, we identified a novel variant p.Gly674Trp of WFS1 as the primary pathogenic variant causing the low-frequency sensorineural HL, enriching the mutational spectrum of the WFS1 gene.PMID:34258273 | PMC:PMC8260318 | DOI:10.1155/2021/6624744 (Source: Biomed Res)
Source: Biomed Res - July 14, 2021 Category: Research Authors: Jinying Li Hongen Xu Jianfeng Sun Yongan Tian Danhua Liu Yaping Qin Huanfei Liu Ruijun Li Lingling Neng Xiaohua Deng Binbin Xue Changyun Yu Wenxue Tang Source Type: research

Moroccan Bee Bread Improves Biochemical and Histological Changes of the Brain, Liver, and Kidneys Induced by Titanium Dioxide Nanoparticles
Biomed Res Int. 2021 Jun 23;2021:6632128. doi: 10.1155/2021/6632128. eCollection 2021.ABSTRACTTitanium dioxide nanoparticles (TiO2) were used in various fields such as food industry, cosmetics, medicine, and agriculture. Despite the many advantages of nanotechnology, the adverse effects of nanoparticles are inevitable. The present study was conducted to evaluate the protective effect of bee bread on titanium dioxide (TiO2) nanoparticle toxicity. Male rats were randomly divided into four groups: Group 1 received daily by gavage (10 mL/kg bw) of distilled water, Group 2 received bee bread ethanolic extract (100 mg/kg bw), Gr...
Source: Biomed Res - July 14, 2021 Category: Research Authors: Meryem Bakour Nawal Hammas Hassan Laaroussi Driss Ousaaid Hinde El Fatemi Abderrazak Aboulghazi Najoua Soulo Badiaa Lyoussi Source Type: research

The Effect of Integrated Intervention Based on Protection Motivation Theory and Implementation Intention to Promote Physical Activity and Physiological Indicators of Patients with Type 2 Diabetes
Biomed Res Int. 2021 Jun 22;2021:6637656. doi: 10.1155/2021/6637656. eCollection 2021.ABSTRACTDespite benefits of physical activity, the level of physical activity is not desirable in patients with type 2 diabetes. The aim of this study is the using of integration of intervention based on the theory of protection motivation and implementation intention in order to improve the level of activity in patients with diabetes. This field trial study has been performed on 125 patients with type 2 diabetes. Samples have been randomly selected, and they are divided into two intervention and control groups. In the intervention group,...
Source: Biomed Res - July 14, 2021 Category: Research Authors: Mohammad Ali Morowatisharifabad Mohammad Asadpour Mohammad Ali Zakeri Mahdi Abdolkarimi Source Type: research

Correlations between FTO Gene Polymorphisms and TSH Level in Uyghur Chinese Patients with Type 2 Diabetes
Biomed Res Int. 2021 Jun 26;2021:6646750. doi: 10.1155/2021/6646750. eCollection 2021.ABSTRACTOBJECTIVE: The aim of this study was to investigate the correlation between polymorphisms in the FTO gene and TSH level in Uyghur patients with type 2 diabetes in the Xinjiang region. Material and Methods. This cohort was made up of 498 Uyghur patients with type 2 diabetes who underwent genotype screening for rs8050136 and rs9939609 using the Sequenom MassARRAY system. The distribution frequencies of the genotypes and alleles at rs8050136 and rs993960 were compared between two patient groups, those with TSH
Source: Biomed Res - July 14, 2021 Category: Research Authors: Li Wang QiZhong Yi Hua Yao LiJuan He BinBin Fang WeiFang Xu YinXia Su JiWen Liu Qi Ma Source Type: research

Real-World Study of Cisplatin, Etoposide, and Bleomycin Chemotherapy Regimen in Gestational Trophoblastic Neoplasia
CONCLUSIONS: BEP regimen was effective in the treatment of GTINs. The treatment was well tolerated, with no safety concerns on patients' fertility.PMID:34258277 | PMC:PMC8249144 | DOI:10.1155/2021/6661698 (Source: Biomed Res)
Source: Biomed Res - July 14, 2021 Category: Research Authors: Ming Wang Lianna Shen Xiaohong Xu Wei Duan Jinwei Miao Weimin Kong Li Su Yumei Wu Source Type: research

Genome Features and < em > In Vitro < /em > Activity against Influenza A and SARS-CoV-2 Viruses of Six Probiotic Strains
CONCLUSIONS: The studied probiotic bacteria are safe, have antiviral activity, and are of great importance for the prevention of diseases caused by respiratory viruses that can also infect the human intestine.PMID:34258278 | PMC:PMC8225420 | DOI:10.1155/2021/6662027 (Source: Biomed Res)
Source: Biomed Res - July 14, 2021 Category: Research Authors: Irina V Soloveva Tatyana N Ilyicheva Vasiliy Yu Marchenko Oleg V Pyankov Anna G Tochilina Irina V Belova Vladimir A Zhirnov Nikolay I Bormotov Maksim O Skarnovich Aleksander G Durymanov Svetlana B Molodtsova Ekaterina I Filippova Alena S Ovchinnikova Anas Source Type: research