In vitro evaluation of bone cell response to novel 3D-printable nanocomposite biomaterials for bone reconstruction
J Biomed Mater Res A. 2024 Apr 15. doi: 10.1002/jbm.a.37719. Online ahead of print.ABSTRACTCritically-sized segmental bone defects represent significant challenges requiring grafts for reconstruction. 3D-printed synthetic bone grafts are viable alternatives to structural allografts if engineered to provide appropriate mechanical performance and osteoblast/osteoclast cell responses. Novel 3D-printable nanocomposites containing acrylated epoxidized soybean oil (AESO) or methacrylated AESO (mAESO), polyethylene glycol diacrylate, and nanohydroxyapatite (nHA) were produced using masked stereolithography. The effects of volume ...
Source: Biomed Res - April 15, 2024 Category: Research Authors: Zahra Haghpanah Dibakar Mondal Nikan Momenbeitollahi Sadaf Mohsenkhani Kiyoumars Zarshenas Yutong Jin Michael Watson Thomas Willett Maud Gorbet Source Type: research
Identification of Novel Molecular and Clinical Biomarkers of Survival in Glioblastoma Multiforme Patients: A Study Based on The Cancer Genome Atlas Data
This study is aimed at investigating the genetic alterations and clinical features of GBM patients to find predictors of survival. GBM patients' methylation and gene expression data along with clinical information from TCGA were retrieved. The most overrepresented pathways were identified independently for each omics dataset. From the genes found in at least 30% of these pathways, one gene that was identified in both sets was further examined using the Kaplan-Meier method for survival analysis. Additionally, three groups of patients who started radio and chemotherapy at different times were identified, and the influence of...
Source: Biomed Res - April 12, 2024 Category: Research Authors: Lu ísa Esteves Francisco Caramelo Domingos Roda Isabel Marques Carreira Joana Barbosa Melo Ilda Patr ícia Ribeiro Source Type: research
Bonding Effectiveness of Saliva-Contaminated Monolithic Zirconia Ceramics Using Different Decontamination Protocols
CONCLUSIONS: Universal cleaning agents can be preferred as an efficient cleaning method with 10-MDP-containing cement after saliva contamination for better adhesive bond strength of 4 mm crown preparation height of monolithic zirconia ceramics.PMID:38606199 | PMC:PMC11008971 | DOI:10.1155/2024/6670159 (Source: Biomed Res)
Source: Biomed Res - April 12, 2024 Category: Research Authors: Necla Demir Ozge Genc Ipek Balevi Akkese Meral Arslan Malkoc Mutlu Ozcan Source Type: research
Effect of radiation cross-linked collagen scaffold in alveolar ridge preservation of extraction socket
This study aimed to evaluate the properties of radiation cross-linked collagen scaffold (RCS) and its efficacy for alveolar ridge preservation (ARP). RCS was prepared from collagen dispersion by electron beam irradiation and freeze-drying. The microstructure, swelling ratio, area alteration and mechanical properties of RCS were characterized. Fifty-four New Zealand rabbits performing incisor extraction on maxilla and mandible were randomly assigned into positive, sham operation or treatment groups. Micro-computed tomography (micro-CT) scans, performed after 1, 4, and 12 weeks of surgery, were to assess changes in ridge hei...
Source: Biomed Res - April 12, 2024 Category: Research Authors: Hongwei Li Chen Yang Gong Chen Bozhao Wang Jian Li Ling Xu Source Type: research
Identification of Novel Molecular and Clinical Biomarkers of Survival in Glioblastoma Multiforme Patients: A Study Based on The Cancer Genome Atlas Data
This study is aimed at investigating the genetic alterations and clinical features of GBM patients to find predictors of survival. GBM patients' methylation and gene expression data along with clinical information from TCGA were retrieved. The most overrepresented pathways were identified independently for each omics dataset. From the genes found in at least 30% of these pathways, one gene that was identified in both sets was further examined using the Kaplan-Meier method for survival analysis. Additionally, three groups of patients who started radio and chemotherapy at different times were identified, and the influence of...
Source: Biomed Res - April 12, 2024 Category: Research Authors: Lu ísa Esteves Francisco Caramelo Domingos Roda Isabel Marques Carreira Joana Barbosa Melo Ilda Patr ícia Ribeiro Source Type: research
Bonding Effectiveness of Saliva-Contaminated Monolithic Zirconia Ceramics Using Different Decontamination Protocols
CONCLUSIONS: Universal cleaning agents can be preferred as an efficient cleaning method with 10-MDP-containing cement after saliva contamination for better adhesive bond strength of 4 mm crown preparation height of monolithic zirconia ceramics.PMID:38606199 | PMC:PMC11008971 | DOI:10.1155/2024/6670159 (Source: Biomed Res)
Source: Biomed Res - April 12, 2024 Category: Research Authors: Necla Demir Ozge Genc Ipek Balevi Akkese Meral Arslan Malkoc Mutlu Ozcan Source Type: research
Effect of radiation cross-linked collagen scaffold in alveolar ridge preservation of extraction socket
This study aimed to evaluate the properties of radiation cross-linked collagen scaffold (RCS) and its efficacy for alveolar ridge preservation (ARP). RCS was prepared from collagen dispersion by electron beam irradiation and freeze-drying. The microstructure, swelling ratio, area alteration and mechanical properties of RCS were characterized. Fifty-four New Zealand rabbits performing incisor extraction on maxilla and mandible were randomly assigned into positive, sham operation or treatment groups. Micro-computed tomography (micro-CT) scans, performed after 1, 4, and 12 weeks of surgery, were to assess changes in ridge hei...
Source: Biomed Res - April 12, 2024 Category: Research Authors: Hongwei Li Chen Yang Gong Chen Bozhao Wang Jian Li Ling Xu Source Type: research
Identification of Novel Molecular and Clinical Biomarkers of Survival in Glioblastoma Multiforme Patients: A Study Based on The Cancer Genome Atlas Data
This study is aimed at investigating the genetic alterations and clinical features of GBM patients to find predictors of survival. GBM patients' methylation and gene expression data along with clinical information from TCGA were retrieved. The most overrepresented pathways were identified independently for each omics dataset. From the genes found in at least 30% of these pathways, one gene that was identified in both sets was further examined using the Kaplan-Meier method for survival analysis. Additionally, three groups of patients who started radio and chemotherapy at different times were identified, and the influence of...
Source: Biomed Res - April 12, 2024 Category: Research Authors: Lu ísa Esteves Francisco Caramelo Domingos Roda Isabel Marques Carreira Joana Barbosa Melo Ilda Patr ícia Ribeiro Source Type: research
Bonding Effectiveness of Saliva-Contaminated Monolithic Zirconia Ceramics Using Different Decontamination Protocols
CONCLUSIONS: Universal cleaning agents can be preferred as an efficient cleaning method with 10-MDP-containing cement after saliva contamination for better adhesive bond strength of 4 mm crown preparation height of monolithic zirconia ceramics.PMID:38606199 | PMC:PMC11008971 | DOI:10.1155/2024/6670159 (Source: Biomed Res)
Source: Biomed Res - April 12, 2024 Category: Research Authors: Necla Demir Ozge Genc Ipek Balevi Akkese Meral Arslan Malkoc Mutlu Ozcan Source Type: research
Effect of radiation cross-linked collagen scaffold in alveolar ridge preservation of extraction socket
This study aimed to evaluate the properties of radiation cross-linked collagen scaffold (RCS) and its efficacy for alveolar ridge preservation (ARP). RCS was prepared from collagen dispersion by electron beam irradiation and freeze-drying. The microstructure, swelling ratio, area alteration and mechanical properties of RCS were characterized. Fifty-four New Zealand rabbits performing incisor extraction on maxilla and mandible were randomly assigned into positive, sham operation or treatment groups. Micro-computed tomography (micro-CT) scans, performed after 1, 4, and 12 weeks of surgery, were to assess changes in ridge hei...
Source: Biomed Res - April 12, 2024 Category: Research Authors: Hongwei Li Chen Yang Gong Chen Bozhao Wang Jian Li Ling Xu Source Type: research
Synthetic strategy for the production of electrically polarized polyvinylidene fluoride-trifluoroethylene-co-polymer osseo-functionalized with hydroxyapatite scaffold
J Biomed Mater Res A. 2024 Apr 10. doi: 10.1002/jbm.a.37720. Online ahead of print.ABSTRACTThe physiological mechanism of bone tissue regeneration is intricately organized and involves several cell types, intracellular, and extracellular molecular signaling networks. To overcome the drawbacks of autografts and allografts, a number of synthetically produced scaffolds have been manufactured by integrating ceramics, polymers, and their hybrid-composites. Considering the fact that natural bone is composed primarily of collagen and hydroxyapatite, ceramic-polymer composite materials seem to be the most viable alternative to bon...
Source: Biomed Res - April 11, 2024 Category: Research Authors: Subhasmita Swain Rojaleen Lenka Tapash Rautray Source Type: research
Gut and Vaginal Microbiota in the Endometriosis: Systematic Review and Meta-Analysis
CONCLUSION: In intestinal and vaginal samples from women with endometriosis, alpha-diversity did not present a significant difference when compared to the control population. However, each study individually showed a possible relationship between the female microbiota and endometriosis. This trial is registered with CRD42021260972.PMID:38601772 | PMC:PMC11006450 | DOI:10.1155/2023/2675966 (Source: Biomed Res)
Source: Biomed Res - April 11, 2024 Category: Research Authors: Tamy Colonetti Maria Carolina Saggioratto Antonio Jos é Grande Laura Colonetti Jo ão Carlos Denoni Junior Luciane Bisognin Ceretta Leonardo Roever F ábio Rosa Silva Maria In ês da Rosa Source Type: research
In vivo effects of cell seeding technique in an ex vivo regional gene therapy model for bone regeneration
This study investigated if human adipose-derived stem cells (ASCs) transduced with a lentiviral vector to overexpress bone morphogenetic protein 2 (BMP-2) and loaded on a scaffold using dynamic orbital shaker could reduce the total cell dose required to heal a critical sized bone defect when compared with static seeding. Human ASCs were loaded onto a collagen/biphasic ceramic scaffold using static loading and dynamic orbital shaker techniques, compared with our labs standard loading technique, and implanted into femoral defects of nude rats. Both a low dose and standard dose of transduced cells were evaluated. Outcomes inv...
Source: Biomed Res - April 11, 2024 Category: Research Authors: Jennifer A Bell Cory K Mayfield Kevin Collon Stephanie Chang Matthew C Gallo Elizabeth Lechtholz-Zey Mina Ayad Osamu Sugiyam Amy H Tang Sang-Hyun Park Jay R Lieberman Source Type: research
Synthetic strategy for the production of electrically polarized polyvinylidene fluoride-trifluoroethylene-co-polymer osseo-functionalized with hydroxyapatite scaffold
J Biomed Mater Res A. 2024 Apr 10. doi: 10.1002/jbm.a.37720. Online ahead of print.ABSTRACTThe physiological mechanism of bone tissue regeneration is intricately organized and involves several cell types, intracellular, and extracellular molecular signaling networks. To overcome the drawbacks of autografts and allografts, a number of synthetically produced scaffolds have been manufactured by integrating ceramics, polymers, and their hybrid-composites. Considering the fact that natural bone is composed primarily of collagen and hydroxyapatite, ceramic-polymer composite materials seem to be the most viable alternative to bon...
Source: Biomed Res - April 11, 2024 Category: Research Authors: Subhasmita Swain Rojaleen Lenka Tapash Rautray Source Type: research
Gut and Vaginal Microbiota in the Endometriosis: Systematic Review and Meta-Analysis
CONCLUSION: In intestinal and vaginal samples from women with endometriosis, alpha-diversity did not present a significant difference when compared to the control population. However, each study individually showed a possible relationship between the female microbiota and endometriosis. This trial is registered with CRD42021260972.PMID:38601772 | PMC:PMC11006450 | DOI:10.1155/2023/2675966 (Source: Biomed Res)
Source: Biomed Res - April 11, 2024 Category: Research Authors: Tamy Colonetti Maria Carolina Saggioratto Antonio Jos é Grande Laura Colonetti Jo ão Carlos Denoni Junior Luciane Bisognin Ceretta Leonardo Roever F ábio Rosa Silva Maria In ês da Rosa Source Type: research
