Applicability of High-Frequency Ultrasound to the Early Diagnosis of Diabetic Peripheral Neuropathy
This study investigated the applicability of high-frequency ultrasound (HFU) to the early diagnosis of diabetic peripheral neuropathy (DPN). Patients with type 2 diabetes (N = 60) were divided into diabetic nonperipheral neuropathy and DPN groups (group A and group B, respectively; n = 30 each) based on electroneurophysiologic findings. Additionally, 30 nondiabetic patients were included as the healthy control group (group C). We calculated the cross-sectional area (CSA) of the median nerve (MN) of the right upper limb at 7 different sites (MN1-7) based on measured width (W) and thickness (T). Ultrasound imaging characteri...
Source: Biomed Res - April 8, 2021 Category: Research Authors: Xishun Ma Tongxia Li Lizhen Du Gang Liu Ting Sun Tongliang Han Source Type: research

Determination of Pesticide Residues in Food Premises Using QuECHERS Method in Bench-Sheko Zone, Southwest Ethiopia
Biomed Res Int. 2021 Mar 19;2021:6612096. doi: 10.1155/2021/6612096. eCollection 2021.ABSTRACTPesticides are risk factors in human life causing chronic human health effects. They are commonly used across the globe to enhance human endeavors. In Ethiopia, pesticides are widely used by local farmers and governmental organizations for pest control purpose. Pesticide residues in food items have been a concern to the consumers and environment they live in. Therefore, this study was aimed at determining the amount of organochlorine and organophosphate pesticide residues in cereal crops in Bench-Sheko Zone, Ethiopia. A cross-sect...
Source: Biomed Res - April 8, 2021 Category: Research Authors: Besufekad Mekonnen Jafer Siraj Samuel Negash Source Type: research

L Antigen Family Member 3 Serves as a Prognostic Biomarker for the Clinical Outcome and Immune Infiltration in Skin Cutaneous Melanoma
Biomed Res Int. 2021 Mar 18;2021:6648182. doi: 10.1155/2021/6648182. eCollection 2021.ABSTRACTL Antigen Family Member 3 (LAGE3) is an important RNA modification-related protein. Whereas few studies have interrogated the LAGE3 protein, there is limited data on its role in tumors. Here, we analyzed and profiled the LAGE3 protein in skin cutaneous melanoma (CM) using TCGA, GTEx, or GEO databases. Our data showed an upregulation of LAGE3 in melanoma cell lines compared to normal skin cell lines. Besides, the Kaplan-Meier curves and Cox proportional hazard model revealed that LAGE3 was an independent survival indicator for CM, ...
Source: Biomed Res - April 8, 2021 Category: Research Authors: Jingjing Song Cong Jin Endong Chen Xubin Dong Libin Zhu Source Type: research

Pharmacokinetic Study of Safrole and Methyl Eugenol after Oral Administration of the Essential Oil Extracts of < em > Asarum < /em > in Rats by GC-MS
In this study, a rapid and simple gas chromatography-mass spectroscopy (GC-MS) method that has a complete run time of only 4.5 min was developed and validated for the simultaneous determination and pharmacokinetic study of safrole and methyl eugenol in rat plasma after administration of Asarum extracts. The chromatographic separation was realized on a DB-17 column (30 m × 0.25 mm × 0.25 μm). And detection was carried out under selected ion monitoring (SIM) mode. Plasma samples were pretreated by n-hexane. The pharmacokinetic parameters provided by this study will be beneficial for further developments and cl...
Source: Biomed Res - April 8, 2021 Category: Research Authors: Yuqi Fan Dongyue Yang Xuhua Huang Guangzhe Yao Wei Wang Mengyuan Gao Xiaohua Jia Huizi Ouyang Yanxu Chang Jun He Source Type: research

Identification of Differentially Expressed Genes in Cervical Cancer Patients by Comparative Transcriptome Analysis
Biomed Res Int. 2021 Mar 19;2021:8810074. doi: 10.1155/2021/8810074. eCollection 2021.ABSTRACTCervical cancer is one of the most malignant reproductive diseases seen in women worldwide. The identification of dysregulated genes in clinical samples of cervical cancer may pave the way for development of better prognostic markers and therapeutic targets. To identify the dysregulated genes (DEGs), we have retrospectively collected 10 biopsies, seven from cervical cancer patients and three from normal subjects who underwent a hysterectomy. Total RNA isolated from biopsies was subjected to microarray analysis using the human Clar...
Source: Biomed Res - April 8, 2021 Category: Research Authors: Annapurna S D Deepthi Pasumarthi Akbar Pasha Ravinder Doneti Sheela B Mahendran Botlagunta Vijaya Lakshmi B Smita C Pawar Source Type: research

Determination of Potential Therapeutic Targets and Prognostic Markers of Ovarian Cancer by Bioinformatics Analysis
This study is to study the expression of CXCRs in ovarian cancer tissues and their value in prognosis. The expressions of CXCR1-CXCR7 mRNA between ovarian tumor tissues and normal tissues and in different pathological types of ovarian tumor tissues were compared by ONCOMINE online tool. The relationship between the expression of CXCRs and clinical pathological staging was studied by GEPIA. Kaplan-Meier plotter online tool was used to analyze prognosis. Finally, GO and KEGG analyses and protein interaction network analysis were performed for CXCRs by the DAVID software to predict their function, and cBioPortal was used to i...
Source: Biomed Res - April 8, 2021 Category: Research Authors: Jing Zhang Shouguo Huang Lini Quan Qiu Meng Haiyan Wang Jie Wang Jin Chen Source Type: research

Synthesis and characterization of a photo-cross-linked bioactive polycaprolactone-based osteoconductive biocomposite
In this study, a light cross-linkable biocomposite scaffold based on a photo-cross-linkable poly (propylene fumarate) (PPF)-co-polycaprolactone (PCL) tri-block copolymer was synthesized and characterized. The developed biodegradable scaffold was further modified with β-tricalcium phosphate (β-TCP) bioceramic for bone tissue engineering applications. The developed biocomposite was characterized using H nuclear magnetic resonance and Fourier transform infrared spectroscopy. Moreover, the bioceramic particle size distribution and morphology were evaluated using Brunauer-Emmett-Teller method, X-ray diffraction, and s...
Source: Biomed Res - April 8, 2021 Category: Research Authors: Fateme Razazpour Farhood Najafi Alireza Moshaverinia Seyyed Mostafa Fatemi Shahabi Sima Source Type: research

Engineering and polymeric composition of drug-eluting suture: A review
J Biomed Mater Res A. 2021 Apr 8. doi: 10.1002/jbm.a.37194. Online ahead of print.ABSTRACTSutures are the most popular surgical implants in the global surgical equipment market. They are used for holding tissues together to achieve wound closure. However, controlling the body's immune response to these "foreign bodies" at site of infection is challenging. Natural polymers such as collagen, silk, nylon, and cotton, and synthetic polymers such as polycaprolactone, poly(lactic-co-glycolic acid), poly(p-dioxanone) and so forth, contribute the robust foundation for the engineering of drug-eluting sutures. The incorpor...
Source: Biomed Res - April 8, 2021 Category: Research Authors: Xiaoxuan Deng Muhammad Qasim Azam Ali Source Type: research

Genetic Association of < em > PPARGC1A < /em > Gene Single Nucleotide Polymorphism with Milk Production Traits in Italian Mediterranean Buffalo
This study identified polymorphisms in the PPARGC1A gene in Italian Mediterranean buffaloes and their associations to milk production and quality traits (lactation length, peak milk yield, fat and protein yield, and percentage). As a result, a total of seven SNPs (g.-78A>G, g.224651G>C, g.286986G>A, g.304050G>A, g.325647G>A, g.325817T>C, and g.325997G>A) were identified by DNA pooled sequencing. Analysis of productivity traits within the genotyped animals revealed that the g.286986G>A located at intron 4 was associated with milk production traits, but the g.325817T>C had no association with milk ...
Source: Biomed Res - April 8, 2021 Category: Research Authors: Seyed Mahdi Hosseini Ye Tingzhu Majid Pasandideh Aixin Liang Guohua Hua None Farmanullah Nicola M Schreurs Sayed Haidar Abbas Raza Angela Salzano Giuseppe Campanile Bianca Gasparrini Liguo Yang Source Type: research

Applicability of High-Frequency Ultrasound to the Early Diagnosis of Diabetic Peripheral Neuropathy
This study investigated the applicability of high-frequency ultrasound (HFU) to the early diagnosis of diabetic peripheral neuropathy (DPN). Patients with type 2 diabetes (N = 60) were divided into diabetic nonperipheral neuropathy and DPN groups (group A and group B, respectively; n = 30 each) based on electroneurophysiologic findings. Additionally, 30 nondiabetic patients were included as the healthy control group (group C). We calculated the cross-sectional area (CSA) of the median nerve (MN) of the right upper limb at 7 different sites (MN1-7) based on measured width (W) and thickness (T). Ultrasound imaging characteri...
Source: Biomed Res - April 8, 2021 Category: Research Authors: Xishun Ma Tongxia Li Lizhen Du Gang Liu Ting Sun Tongliang Han Source Type: research

Determination of Pesticide Residues in Food Premises Using QuECHERS Method in Bench-Sheko Zone, Southwest Ethiopia
Biomed Res Int. 2021 Mar 19;2021:6612096. doi: 10.1155/2021/6612096. eCollection 2021.ABSTRACTPesticides are risk factors in human life causing chronic human health effects. They are commonly used across the globe to enhance human endeavors. In Ethiopia, pesticides are widely used by local farmers and governmental organizations for pest control purpose. Pesticide residues in food items have been a concern to the consumers and environment they live in. Therefore, this study was aimed at determining the amount of organochlorine and organophosphate pesticide residues in cereal crops in Bench-Sheko Zone, Ethiopia. A cross-sect...
Source: Biomed Res - April 8, 2021 Category: Research Authors: Besufekad Mekonnen Jafer Siraj Samuel Negash Source Type: research

L Antigen Family Member 3 Serves as a Prognostic Biomarker for the Clinical Outcome and Immune Infiltration in Skin Cutaneous Melanoma
Biomed Res Int. 2021 Mar 18;2021:6648182. doi: 10.1155/2021/6648182. eCollection 2021.ABSTRACTL Antigen Family Member 3 (LAGE3) is an important RNA modification-related protein. Whereas few studies have interrogated the LAGE3 protein, there is limited data on its role in tumors. Here, we analyzed and profiled the LAGE3 protein in skin cutaneous melanoma (CM) using TCGA, GTEx, or GEO databases. Our data showed an upregulation of LAGE3 in melanoma cell lines compared to normal skin cell lines. Besides, the Kaplan-Meier curves and Cox proportional hazard model revealed that LAGE3 was an independent survival indicator for CM, ...
Source: Biomed Res - April 8, 2021 Category: Research Authors: Jingjing Song Cong Jin Endong Chen Xubin Dong Libin Zhu Source Type: research

Pharmacokinetic Study of Safrole and Methyl Eugenol after Oral Administration of the Essential Oil Extracts of < em > Asarum < /em > in Rats by GC-MS
In this study, a rapid and simple gas chromatography-mass spectroscopy (GC-MS) method that has a complete run time of only 4.5 min was developed and validated for the simultaneous determination and pharmacokinetic study of safrole and methyl eugenol in rat plasma after administration of Asarum extracts. The chromatographic separation was realized on a DB-17 column (30 m × 0.25 mm × 0.25 μm). And detection was carried out under selected ion monitoring (SIM) mode. Plasma samples were pretreated by n-hexane. The pharmacokinetic parameters provided by this study will be beneficial for further developments and cl...
Source: Biomed Res - April 8, 2021 Category: Research Authors: Yuqi Fan Dongyue Yang Xuhua Huang Guangzhe Yao Wei Wang Mengyuan Gao Xiaohua Jia Huizi Ouyang Yanxu Chang Jun He Source Type: research

Identification of Differentially Expressed Genes in Cervical Cancer Patients by Comparative Transcriptome Analysis
Biomed Res Int. 2021 Mar 19;2021:8810074. doi: 10.1155/2021/8810074. eCollection 2021.ABSTRACTCervical cancer is one of the most malignant reproductive diseases seen in women worldwide. The identification of dysregulated genes in clinical samples of cervical cancer may pave the way for development of better prognostic markers and therapeutic targets. To identify the dysregulated genes (DEGs), we have retrospectively collected 10 biopsies, seven from cervical cancer patients and three from normal subjects who underwent a hysterectomy. Total RNA isolated from biopsies was subjected to microarray analysis using the human Clar...
Source: Biomed Res - April 8, 2021 Category: Research Authors: Annapurna S D Deepthi Pasumarthi Akbar Pasha Ravinder Doneti Sheela B Mahendran Botlagunta Vijaya Lakshmi B Smita C Pawar Source Type: research

Determination of Potential Therapeutic Targets and Prognostic Markers of Ovarian Cancer by Bioinformatics Analysis
This study is to study the expression of CXCRs in ovarian cancer tissues and their value in prognosis. The expressions of CXCR1-CXCR7 mRNA between ovarian tumor tissues and normal tissues and in different pathological types of ovarian tumor tissues were compared by ONCOMINE online tool. The relationship between the expression of CXCRs and clinical pathological staging was studied by GEPIA. Kaplan-Meier plotter online tool was used to analyze prognosis. Finally, GO and KEGG analyses and protein interaction network analysis were performed for CXCRs by the DAVID software to predict their function, and cBioPortal was used to i...
Source: Biomed Res - April 8, 2021 Category: Research Authors: Jing Zhang Shouguo Huang Lini Quan Qiu Meng Haiyan Wang Jie Wang Jin Chen Source Type: research

Synthesis and characterization of a photo-cross-linked bioactive polycaprolactone-based osteoconductive biocomposite
In this study, a light cross-linkable biocomposite scaffold based on a photo-cross-linkable poly (propylene fumarate) (PPF)-co-polycaprolactone (PCL) tri-block copolymer was synthesized and characterized. The developed biodegradable scaffold was further modified with β-tricalcium phosphate (β-TCP) bioceramic for bone tissue engineering applications. The developed biocomposite was characterized using H nuclear magnetic resonance and Fourier transform infrared spectroscopy. Moreover, the bioceramic particle size distribution and morphology were evaluated using Brunauer-Emmett-Teller method, X-ray diffraction, and s...
Source: Biomed Res - April 8, 2021 Category: Research Authors: Fateme Razazpour Farhood Najafi Alireza Moshaverinia Seyyed Mostafa Fatemi Shahabi Sima Source Type: research

Engineering and polymeric composition of drug-eluting suture: A review
J Biomed Mater Res A. 2021 Apr 8. doi: 10.1002/jbm.a.37194. Online ahead of print.ABSTRACTSutures are the most popular surgical implants in the global surgical equipment market. They are used for holding tissues together to achieve wound closure. However, controlling the body's immune response to these "foreign bodies" at site of infection is challenging. Natural polymers such as collagen, silk, nylon, and cotton, and synthetic polymers such as polycaprolactone, poly(lactic-co-glycolic acid), poly(p-dioxanone) and so forth, contribute the robust foundation for the engineering of drug-eluting sutures. The incorpor...
Source: Biomed Res - April 8, 2021 Category: Research Authors: Xiaoxuan Deng Muhammad Qasim Azam Ali Source Type: research

Triclosan inhibits the activation of human periodontal ligament fibroblasts induced by lipopolysaccharide from < em > Porphyromonas gingivalis < /em >
This study aims to examine the efficacy and protective mechanism of triclosan (TCS), a bisphenolic, non-cationic component of oral care products, against periodontal inflammation induced by lipopolysaccharide purified from Porphyromonas gingivalis (LPS-PG). TCS markedly downregulated IL-6, IL-8, and IL-15 in human periodontal ligament fibroblasts (HPDLFs) treated with LPS-PG. By using a liquid chromatography-tandem mass spectrometry (LC-MS/MS) approach, 318 differentially expressed proteins (161 upregulated and 157 downregulated) were identified in TCS-pretreated HPDLFs. TCS upregulated HSPA5 and HSP90B1 but downregulated ...
Source: Biomed Res - April 7, 2021 Category: Research Authors: Wei Shu Yanman Zhang Chen Zhang Qiang You Hong Zhou Shuang Wen Source Type: research

Diagnostic Accuracy of EndoFaster ® and Narrow-Band Imaging Endoscopy in Patients with Impaired Gastric Acid Secretion: A Real-Time Prospective Study
Gastroenterol Res Pract. 2021 Mar 20;2021:6616334. doi: 10.1155/2021/6616334. eCollection 2021.ABSTRACTBACKGROUND: EndoFaster® analyzes gastric juice in real time during gastroscopy allowing the detection of hypo-achlorhydric conditions, like corpus atrophic gastritis. Narrow-band imaging (NBI) endoscopy allows to accurately detect and perform target biopsies in areas of intestinal metaplasia, a histological change often associated to corpus atrophic gastritis.AIMS: To compare the diagnostic accuracy of EndoFaster® with histological evaluation for corpus atrophic gastritis through high-resolution (HR) NBI targeted ...
Source: Biomed Res - April 7, 2021 Category: Research Authors: M Cazzato G Esposito G Galli E Pilozzi E Lahner V D Corleto A Zullo E Di Giulio B Annibale Source Type: research

Uncovering the Pharmacology of Xiaochaihu Decoction in the Treatment of Acute Pancreatitis Based on the Network Pharmacology
CONCLUSION: This study illustrated that XCHD and Quercetin contained in XD played an important role in the treatment of acute pancreatitis by acting on the key genes of MPAK3, IL-6, and TP53 which were associated with inflammation and apoptosis.PMID:33824873 | PMC:PMC8007340 | DOI:10.1155/2021/6621682 (Source: Biomed Res)
Source: Biomed Res - April 7, 2021 Category: Research Authors: Lianghui Zhan Jinbao Pu Yijuan Hu Pan Xu Weiqing Liang Chunlian Ji Source Type: research

COPB2: A Novel Prognostic Biomarker That Affects Progression of HCC
This study is aimed at investigating the expression, underlying biological function, and clinical significance of coatomer protein complex subunit beta 2 (COPB2) in hepatocellular carcinoma (HCC).METHODS: HCC-related data were extracted from The Cancer Genome Atlas (TCGA) database, International Cancer Genome Consortium (ICGC) database, and Gene Expression Omnibus (GEO) database. A logistic regression module was applied to analyze the relationship between the expression of COPB2 and clinicopathologic characteristics. The Cox proportional hazard regression model and Kaplan-Meier method were used for survival analysis. Gene ...
Source: Biomed Res - April 7, 2021 Category: Research Authors: Jiayao Zhang Xiaoyu Wang Guangbing Li Jingyi He Ziwen Lu Yang Yang Yong Jiang Liyong Jiang Feiyu Li Jun Liu Source Type: research

Effect of LongZhang Gargle on Dual-Species Biofilm of Candida albicans and Streptococcus mutans
Biomed Res Int. 2021 Mar 22;2021:6654793. doi: 10.1155/2021/6654793. eCollection 2021.ABSTRACTBioactive natural products have become a hot spot for oral disease treatments. At the present study, LongZhang Gargle was investigated for its effects on single-species biofilms of Candida albicans and dual-species biofilms of Candida albicans and Streptococcus mutans. Two different models of single and dual-species biofilms were grown in YNBB medium under appropriate conditions. Biofilm biomass, biofilm architecture, and cell activity in biofilms were assessed using Crystal Violet Staining, MTT, scanning electron microscopy (SEM)...
Source: Biomed Res - April 7, 2021 Category: Research Authors: Jinglei Gong Die Hu Jinzhi He Ling Zou Zhu Chen Mingyun Li Source Type: research

< em > TCF7L1 < /em > Genetic Variants Are Associated with the Susceptibility to Cervical Cancer in a Chinese Population
CONCLUSION: Rs11904127 and rs62162674 in TCF7L1 are related to cervical cancer. We suggest that these variants can be used as prognostic markers for judging the susceptibility to cervical cancer.PMID:33824876 | PMC:PMC8007361 | DOI:10.1155/2021/6670456 (Source: Biomed Res)
Source: Biomed Res - April 7, 2021 Category: Research Authors: Jingjing Chen Yuanfang Xu Hongyuan Hu Tianbo Jin Source Type: research

Oblique Lateral Interbody Fusion versus Transforaminal Lumbar Interbody Fusion in Degenerative Lumbar Spondylolisthesis: A Single-Center Retrospective Comparative Study
CONCLUSIONS: Compared with TLIF, OLIF showed the advantages of less surgical invasion, better decompression effect, and faster postoperative recovery in single-level DLS surgery.PMID:33824877 | PMC:PMC8007343 | DOI:10.1155/2021/6693446 (Source: Biomed Res)
Source: Biomed Res - April 7, 2021 Category: Research Authors: Xing Du Yuxiao She Yunsheng Ou Yong Zhu Wei Luo Dianming Jiang Source Type: research

Current Advances in DNA Methylation Analysis Methods
Biomed Res Int. 2021 Mar 20;2021:8827516. doi: 10.1155/2021/8827516. eCollection 2021.ABSTRACTDNA methylation is one of the epigenetic changes, which plays a major role in regulating gene expression and, thus, many biological processes and diseases. There are several methods for determining the methylation of DNA samples. However, selecting the most appropriate method for answering biological questions appears to be a challenging task. The primary methods in DNA methylation focused on identifying the state of methylation of the examined genes and determining the total amount of 5-methyl cytosine. The study of DNA methylati...
Source: Biomed Res - April 7, 2021 Category: Research Authors: Ehsan Khodadadi Leila Fahmideh Ehsaneh Khodadadi Sounkalo Dao Mehdi Yousefi Sepehr Taghizadeh Mohammad Asgharzadeh Bahman Yousefi Hossein Samadi Kafil Source Type: research

Sedentary Behaviour among Urban Civil Servants in Eastern Part of Southern Nations, Nationalities and Peoples' Region, Ethiopia
This study is aimed at determining the amount of time spent on sedentary activity and identifying sedentary behaviours frequently practiced by civil servants in Southern Ethiopia in 2015.METHODS: It was a cross-sectional study which employed both qualitative and quantitative approach. A stratified cluster sampling method was used to select 375 office workers (222 men and 153 women) from Hawassa, Wolayta Soddo, and Dilla ranging from 18-65 years old. Data were collected using harmonized self-reporting LASSA (Longitudinal Aging Study Amsterdam) questionnaires and prevalence estimates of mean sedentary time in each 12 activit...
Source: Biomed Res - April 7, 2021 Category: Research Authors: Markos Yohannes Baye Source Type: research

Dual response of osteoblast activity and antibacterial properties of polarized strontium substituted hydroxyapatite-Barium strontium titanate composites with controlled strontium substitution
J Biomed Mater Res A. 2021 Apr 7. doi: 10.1002/jbm.a.37195. Online ahead of print.ABSTRACTTo mimic the electrical properties of natural bone, controlled strontium substitution of both hydroxyapatite and ferroelectric barium titanate were achieved by mixing in the ratio 30:70 by weight. The composites were characterized by X-ray diffraction, Fourier transform infrared spectroscopy and scanning electron microscopy to investigate the phase composition and microstructure of the composites. Unpolarized and polarized strontium hydroxyapatite (SrHA)-barium strontium titanate (BST) composites with controlled degree of Sr substitut...
Source: Biomed Res - April 7, 2021 Category: Research Authors: Subhasmita Swain Chris Bowen Tapash Rautray Source Type: research

Triclosan inhibits the activation of human periodontal ligament fibroblasts induced by lipopolysaccharide from < em > Porphyromonas gingivalis < /em >
This study aims to examine the efficacy and protective mechanism of triclosan (TCS), a bisphenolic, non-cationic component of oral care products, against periodontal inflammation induced by lipopolysaccharide purified from Porphyromonas gingivalis (LPS-PG). TCS markedly downregulated IL-6, IL-8, and IL-15 in human periodontal ligament fibroblasts (HPDLFs) treated with LPS-PG. By using a liquid chromatography-tandem mass spectrometry (LC-MS/MS) approach, 318 differentially expressed proteins (161 upregulated and 157 downregulated) were identified in TCS-pretreated HPDLFs. TCS upregulated HSPA5 and HSP90B1 but downregulated ...
Source: Biomed Res - April 7, 2021 Category: Research Authors: Wei Shu Yanman Zhang Chen Zhang Qiang You Hong Zhou Shuang Wen Source Type: research

Diagnostic Accuracy of EndoFaster ® and Narrow-Band Imaging Endoscopy in Patients with Impaired Gastric Acid Secretion: A Real-Time Prospective Study
Gastroenterol Res Pract. 2021 Mar 20;2021:6616334. doi: 10.1155/2021/6616334. eCollection 2021.ABSTRACTBACKGROUND: EndoFaster® analyzes gastric juice in real time during gastroscopy allowing the detection of hypo-achlorhydric conditions, like corpus atrophic gastritis. Narrow-band imaging (NBI) endoscopy allows to accurately detect and perform target biopsies in areas of intestinal metaplasia, a histological change often associated to corpus atrophic gastritis.AIMS: To compare the diagnostic accuracy of EndoFaster® with histological evaluation for corpus atrophic gastritis through high-resolution (HR) NBI targeted ...
Source: Biomed Res - April 7, 2021 Category: Research Authors: M Cazzato G Esposito G Galli E Pilozzi E Lahner V D Corleto A Zullo E Di Giulio B Annibale Source Type: research

Uncovering the Pharmacology of Xiaochaihu Decoction in the Treatment of Acute Pancreatitis Based on the Network Pharmacology
CONCLUSION: This study illustrated that XCHD and Quercetin contained in XD played an important role in the treatment of acute pancreatitis by acting on the key genes of MPAK3, IL-6, and TP53 which were associated with inflammation and apoptosis.PMID:33824873 | PMC:PMC8007340 | DOI:10.1155/2021/6621682 (Source: Biomed Res)
Source: Biomed Res - April 7, 2021 Category: Research Authors: Lianghui Zhan Jinbao Pu Yijuan Hu Pan Xu Weiqing Liang Chunlian Ji Source Type: research

COPB2: A Novel Prognostic Biomarker That Affects Progression of HCC
This study is aimed at investigating the expression, underlying biological function, and clinical significance of coatomer protein complex subunit beta 2 (COPB2) in hepatocellular carcinoma (HCC).METHODS: HCC-related data were extracted from The Cancer Genome Atlas (TCGA) database, International Cancer Genome Consortium (ICGC) database, and Gene Expression Omnibus (GEO) database. A logistic regression module was applied to analyze the relationship between the expression of COPB2 and clinicopathologic characteristics. The Cox proportional hazard regression model and Kaplan-Meier method were used for survival analysis. Gene ...
Source: Biomed Res - April 7, 2021 Category: Research Authors: Jiayao Zhang Xiaoyu Wang Guangbing Li Jingyi He Ziwen Lu Yang Yang Yong Jiang Liyong Jiang Feiyu Li Jun Liu Source Type: research

Effect of LongZhang Gargle on Dual-Species Biofilm of Candida albicans and Streptococcus mutans
Biomed Res Int. 2021 Mar 22;2021:6654793. doi: 10.1155/2021/6654793. eCollection 2021.ABSTRACTBioactive natural products have become a hot spot for oral disease treatments. At the present study, LongZhang Gargle was investigated for its effects on single-species biofilms of Candida albicans and dual-species biofilms of Candida albicans and Streptococcus mutans. Two different models of single and dual-species biofilms were grown in YNBB medium under appropriate conditions. Biofilm biomass, biofilm architecture, and cell activity in biofilms were assessed using Crystal Violet Staining, MTT, scanning electron microscopy (SEM)...
Source: Biomed Res - April 7, 2021 Category: Research Authors: Jinglei Gong Die Hu Jinzhi He Ling Zou Zhu Chen Mingyun Li Source Type: research

< em > TCF7L1 < /em > Genetic Variants Are Associated with the Susceptibility to Cervical Cancer in a Chinese Population
CONCLUSION: Rs11904127 and rs62162674 in TCF7L1 are related to cervical cancer. We suggest that these variants can be used as prognostic markers for judging the susceptibility to cervical cancer.PMID:33824876 | PMC:PMC8007361 | DOI:10.1155/2021/6670456 (Source: Biomed Res)
Source: Biomed Res - April 7, 2021 Category: Research Authors: Jingjing Chen Yuanfang Xu Hongyuan Hu Tianbo Jin Source Type: research

Oblique Lateral Interbody Fusion versus Transforaminal Lumbar Interbody Fusion in Degenerative Lumbar Spondylolisthesis: A Single-Center Retrospective Comparative Study
CONCLUSIONS: Compared with TLIF, OLIF showed the advantages of less surgical invasion, better decompression effect, and faster postoperative recovery in single-level DLS surgery.PMID:33824877 | PMC:PMC8007343 | DOI:10.1155/2021/6693446 (Source: Biomed Res)
Source: Biomed Res - April 7, 2021 Category: Research Authors: Xing Du Yuxiao She Yunsheng Ou Yong Zhu Wei Luo Dianming Jiang Source Type: research

Current Advances in DNA Methylation Analysis Methods
Biomed Res Int. 2021 Mar 20;2021:8827516. doi: 10.1155/2021/8827516. eCollection 2021.ABSTRACTDNA methylation is one of the epigenetic changes, which plays a major role in regulating gene expression and, thus, many biological processes and diseases. There are several methods for determining the methylation of DNA samples. However, selecting the most appropriate method for answering biological questions appears to be a challenging task. The primary methods in DNA methylation focused on identifying the state of methylation of the examined genes and determining the total amount of 5-methyl cytosine. The study of DNA methylati...
Source: Biomed Res - April 7, 2021 Category: Research Authors: Ehsan Khodadadi Leila Fahmideh Ehsaneh Khodadadi Sounkalo Dao Mehdi Yousefi Sepehr Taghizadeh Mohammad Asgharzadeh Bahman Yousefi Hossein Samadi Kafil Source Type: research

Sedentary Behaviour among Urban Civil Servants in Eastern Part of Southern Nations, Nationalities and Peoples' Region, Ethiopia
This study is aimed at determining the amount of time spent on sedentary activity and identifying sedentary behaviours frequently practiced by civil servants in Southern Ethiopia in 2015.METHODS: It was a cross-sectional study which employed both qualitative and quantitative approach. A stratified cluster sampling method was used to select 375 office workers (222 men and 153 women) from Hawassa, Wolayta Soddo, and Dilla ranging from 18-65 years old. Data were collected using harmonized self-reporting LASSA (Longitudinal Aging Study Amsterdam) questionnaires and prevalence estimates of mean sedentary time in each 12 activit...
Source: Biomed Res - April 7, 2021 Category: Research Authors: Markos Yohannes Baye Source Type: research

Dual response of osteoblast activity and antibacterial properties of polarized strontium substituted hydroxyapatite-Barium strontium titanate composites with controlled strontium substitution
J Biomed Mater Res A. 2021 Apr 7. doi: 10.1002/jbm.a.37195. Online ahead of print.ABSTRACTTo mimic the electrical properties of natural bone, controlled strontium substitution of both hydroxyapatite and ferroelectric barium titanate were achieved by mixing in the ratio 30:70 by weight. The composites were characterized by X-ray diffraction, Fourier transform infrared spectroscopy and scanning electron microscopy to investigate the phase composition and microstructure of the composites. Unpolarized and polarized strontium hydroxyapatite (SrHA)-barium strontium titanate (BST) composites with controlled degree of Sr substitut...
Source: Biomed Res - April 7, 2021 Category: Research Authors: Subhasmita Swain Chris Bowen Tapash Rautray Source Type: research

In vitro comparison of harvesting site effects on cardiac extracellular matrix hydrogels
J Biomed Mater Res A. 2021 Apr 6. doi: 10.1002/jbm.a.37184. Online ahead of print.ABSTRACTCardiac extracellular matrix (cECM) derived hydrogel has been investigated to treat myocardial infarction through animal studies and clinical trials. The tissue harvesting site commonly selects porcine left ventricle (LV) because heart attack majorly takes place in LV. However, little is known about whether the region of cardiac tissue harvesting is critical for downstream applications. In this work, in vitro studies to compare cECM hydrogels derived from adult porcine whole heart (WH), LV, and right ventricle (RV) were performed. The...
Source: Biomed Res - April 6, 2021 Category: Research Authors: Emily Mulvany Sara McMahan Jiazhu Xu Narges Yazdani Rebecca Willits Jun Liao Ge Zhang Yi Hong Source Type: research

Effect of heparinization on promoting angiogenesis of decellularized kidney scaffolds
J Biomed Mater Res A. 2021 Apr 6. doi: 10.1002/jbm.a.37190. Online ahead of print.ABSTRACTNative decellularized extracellular matrix provides an adequate platform for tissues and organs and promotes the development of organogenesis and tissue remodeling. However, thrombosis poses a great challenge that hinders the transplantation for a substantial organ in vivo. Therefore, anticoagulation and re-reendothelialization of organ biological scaffolds are the primary concerns to be addressed before orthotopic transplantation. Herein, a heparinized decellularized kidney scaffold (HEP-DKSs) was prepared using end-point attachment ...
Source: Biomed Res - April 6, 2021 Category: Research Authors: Lebin Zhou Zhiyi Wang Zhibin Wang Junyi Zhu Yulu Feng Deming Zhang Chenfang Shen Xiaoting Ye Jieyang Zhu Peng Wei Jin Mei Jianse Zhang Source Type: research

Left Ventricular Strain: A Reliable Predictor of Short-Term Outcomes in Patients with Anterior Wall Myocardial Infarction without Heart Failure
CONCLUSIONS: In patients with AWMI without HF, PSLS and PSLV are good predictors of adverse outcomes at 30-day follow-up. Furthermore, NT-pro BNP can also be an indirect predictor of strain parameters on echocardiography.PMID:33816386 | PMC:PMC8012861 | DOI:10.4103/abr.abr_213_18 (Source: Biomed Res)
Source: Biomed Res - April 5, 2021 Category: Research Authors: Bonnie R K Singh Rishi Sethi Nirdesh Jain Gaurav Chaudhry Mahim Saran Omkar Mishra Akshyaya Pradhan Source Type: research

Inflammatory Pseudotumor: A 20-Year Single Institutional Experience
CONCLUSION: This study showed a female preponderance of IPT with the head and neck and GIT being the most common location. It is important to rule out other differentials in the diagnosis of IPT.PMID:33816387 | PMC:PMC8012865 | DOI:10.4103/abr.abr_48_20 (Source: Biomed Res)
Source: Biomed Res - April 5, 2021 Category: Research Authors: Mustapha Akanji Ajani Ebenezer O Fatunla Francis A Onakpoma Ayodeji A Salami Source Type: research

Comparisons between Insomnia Incidence after Coronary Artery Bypass Graft Surgery with Coronary Angioplasty
CONCLUSION: Insomnia after both CABG and angioplasty was significantly increased but in CABG group this increase was more than angioplasty.PMID:33816388 | PMC:PMC8012862 | DOI:10.4103/abr.abr_221_20 (Source: Biomed Res)
Source: Biomed Res - April 5, 2021 Category: Research Authors: Aram Yazdani Sayed Mehdi Samimi Ardestani Eznollah Azargashb Mohammad Reza Najarzadegan Kiarash Kohansal Ghazaleh Salehabadi Sayed Saeed Sadr Source Type: research

A Child of Congenital Muscular Dystrophy-Dystroglycanopathy with Homozygous Missense Variation in Exon 3 of the ISPD Gene: A Rare Case from Odisha
Adv Biomed Res. 2020 Nov 28;9:70. doi: 10.4103/abr.abr_141_19. eCollection 2020.ABSTRACTDystroglycanopathy is a type of congenital muscular dystrophy caused by mutations causing defective glycosylation of a dystrophin-associated glycoprotein, dystroglycan and as such is a very rare disease entity. We are reporting a 1-year-old girl child with dystroglycanopathy who presented with motor predominant developmental delay. She had motor development quotient of 52, mental development quotient of 75, facial dysmorphism, mixed hypotonia with a global decrease in muscle power, and areflexia. Serum CPK level was elevated; magnetic r...
Source: Biomed Res - April 5, 2021 Category: Research Authors: Sebaranjan Biswal Debasish Panigrahi Nirmal Kumar Mohakud Manoj Kumar Natabara Swain Source Type: research

Thrombotic Thrombocytopenic Purpura with Conjunctivitis in a Patient with Coronavirus Disease 2019 Infection
This study highlights the atypical behavior of this virus over the course of the disease including TTP with conjunctivitis, which could vary from case to case.PMID:33816390 | PMC:PMC8012864 | DOI:10.4103/abr.abr_190_20 (Source: Biomed Res)
Source: Biomed Res - April 5, 2021 Category: Research Authors: Gholamali Dorooshi Sahar Sadat Lalehzar Maryam Nasri Rokhsareh Meamar Source Type: research

Characterization of the Cognitive and Motor Changes Revealed by the Elevated Plus Maze in an Experimental Rat Model of Radiation-Induced Brain Injury
Adv Biomed Res. 2020 Nov 28;9:72. doi: 10.4103/abr.abr_62_20. eCollection 2020.ABSTRACTBACKGROUND: Experimental models are needed to better understand the pathophysiology of neurodegenerative diseases to develop novel therapeutics. The neuropathology and clinical signs of acute radiation syndrome resemble those of neurodegenerative conditions. We characterized elevated plus maze (EPM) indicators of cognitive and motor impairment in rats exposed to brain-damaging doses of gamma radiation to develop a model for neurological component of the acute radiation syndrome.MATERIALS AND METHODS: Technetium 99 m was administered once...
Source: Biomed Res - April 5, 2021 Category: Research Authors: Alfred K Njamnshi Nene Ahidjo Leonard Ngarka Leonard N Nfor Michel K Mengnjo Wepnyu Y Njamnshi Jonas Guy Basseguin Atchou Godwin Y Tatah Louis M Mbaku Faustin Dong À Zok Paul F Seke Etet Source Type: research

Effectiveness of Ozone Injection Therapy in Temporomandibular Disorders
This report addresses the studies which are conducted clinically, experimentally, and semi-experimentally over the past 10 years (2009-2019). The prepared articles are screened according to the inclusion criteria. In this study, total six related articles are addressed. One study was pre- and postintervention, and five studies were clinical trials. Studies show that although more studies are needed in contrast with occlusal splint, ozone therapy is generally more effective treatment for pain reduction compared to medication.PMID:33816392 | PMC:PMC8012860 | DOI:10.4103/abr.abr_105_20 (Source: Biomed Res)
Source: Biomed Res - April 5, 2021 Category: Research Authors: Sheila Haghighat Samira Oshaghi Source Type: research

Effect of < em > Haemophilus influenzae < /em > Type b Vaccination on Nasopharyngeal Carriage Rate in Children, Tehran, 2019
CONCLUSION: Our findings showed a significant decrease (60%) in the overall Hib nasopharyngeal carriage in healthy children under six years after 5 years after the start of Hib vaccination.PMID:33816612 | PMC:PMC7987433 | DOI:10.1155/2021/4923852 (Source: Biomed Res)
Source: Biomed Res - April 5, 2021 Category: Research Authors: Sedigheh Rafiei Tabatabaei Sara Mohammadzadeh Seyed Mohsen Zahraei Sussan Mahmoudi Ghazaleh Ghandchi Seyedeh Mahsan Hoseini-Alfatemi Abdollah Karimi Ahmadreza Shamshiri Source Type: research

LncRNA RBM5-AS1 Promotes Osteosarcoma Cell Proliferation, Migration, and Invasion
CONCLUSION: To sum up, the results showed that lncRNA RBM5-AS1 promotes cell proliferation, migration, and invasion in Os.PMID:33816613 | PMC:PMC7987434 | DOI:10.1155/2021/5271291 (Source: Biomed Res)
Source: Biomed Res - April 5, 2021 Category: Research Authors: Biyong Deng Runsang Pan Xin Ou Taizhe Wang Weiguo Wang Yingjie Nie Houping Chen Source Type: research

Evaluation of the Relationship between Drink Intake and Periodontitis Using KoGES Data
This study was aimed at investigating the relationship between coffee, green tea, or soft drink intake and periodontitis. This prospective cohort study used epidemiological data from 2004 to 2016 from the Korean Genome and Epidemiology Study. Among 173,209 participants, 9,933 with periodontitis and 124,922 controls were selected. The frequency histories of coffee/green tea/soft drink intake among the participants were analyzed, and intake was categorized as no drink, mild drink (one time a month through six times a week), and heavy drink (one or more times a day). Variable factors were adjusted using logistic regression an...
Source: Biomed Res - April 5, 2021 Category: Research Authors: Seok Jin Hong Bin Kwon Byoung Eun Yang Hyo Geun Choi Soo Hwan Byun Source Type: research

Association between Sleep Duration, Physical Activity, and Mental Health Disorders: A Secondary Analysis of the National Survey of Children's Health 2017-2018
CONCLUSIONS: Insufficient sleep duration and insufficient physical activity in children were associated with mental health disorders. There is a synergistic interaction effect between insufficient sleep duration and insufficient physical activity on current anxiety and current depression.PMID:33816615 | PMC:PMC7987431 | DOI:10.1155/2021/5585678 (Source: Biomed Res)
Source: Biomed Res - April 5, 2021 Category: Research Authors: Shiting Xiang Jie Dong Xun Li Liping Li Source Type: research