Bag-1L Protects against Cell Apoptosis in an In Vitro Model of Lung Ischemia-Reperfusion Injury through the C-Terminal "Bag" Domain
Biomed Res Int. 2021 Mar 17;2021:8822807. doi: 10.1155/2021/8822807. eCollection 2021.ABSTRACTBcl-2-associated athanogene 1 (Bag-1) is a multifunctional and antiapoptotic protein that binds to the antiapoptosis regulator Bcl-2 and promotes cell survival. To investigate the protective function of Bag-1, we examined the effects of Bag-1L, one isoform of Bag-1, in an in vitro cell culture model of lung ischemia-reperfusion injury (LIRI) generated by treatment of A549 cells with hypoxia/reoxygenation. Overexpression of full-length Bag-1L increased the viability of A549 cells and reduced cell apoptosis in response to 6 h of hyp...
Source: Biomed Res - May 31, 2021 Category: Research Authors: Ji-Ling Lv Li-Na Shi Cong-Ying Zhai Ge-Jin Wang Yan Qu Source Type: research

Synthesis, Characterization, and Specific Localization of Mitochondrial-Targeted Antioxidant Peptide SS31 Probe
Biomed Res Int. 2021 May 19;2021:9915699. doi: 10.1155/2021/9915699. eCollection 2021.ABSTRACTThe aim of this study is to investigate the targeting efficiency of FITC-SS31 to mitochondria in both normal and H2O2-induced oxidative damaged 661W cells, characterizing the properties of FITC-SS31 in the biological assays. The purity and molecular weight of FITC-SS31 were identified using HPLC and MS. MTT and LDH assays were used to evaluate the cytotoxicity and cell permeability. The binding ability of FITC-SS31 to cells was demonstrated by flow cytometry. The colocalization of FITC-SS31 and MitoTracker both in normal and oxida...
Source: Biomed Res - May 31, 2021 Category: Research Authors: Yuan He Ruixue Zhang Zhuoya Quan Beilei He Yun Xu Zejun Chen Yuan Ren Xu Liu Source Type: research

Effects of Skeletally Supported Anterior en Masse Retraction with Varied Lever Arm Lengths and Locations in Lingual Orthodontic Treatment: A 3D Finite Element Study
CONCLUSION: All miniscrew heights and lever arm positions showed initial lingual crown tipping and labial root tipping with occlusal crown extrusion. However, the 8 mm miniscrew height and the lever arm located between the lateral incisor and canine showed fewer amounts of these tipping patterns than a 4.5 mm miniscrew height and lever arm located distal to the canines. Therefore, this could be the preferred point of force application during en masse retraction in lingual treatment with additional torque control methods.PMID:34056005 | PMC:PMC8147523 | DOI:10.1155/2021/9975428 (Source: Biomed Res)
Source: Biomed Res - May 31, 2021 Category: Research Authors: Mohammad Ghannam Beste Kamilo ğlu Source Type: research

Decellularized grass as a sustainable scaffold for skeletal muscle tissue engineering
J Biomed Mater Res A. 2021 May 31. doi: 10.1002/jbm.a.37241. Online ahead of print.ABSTRACTScaffold materials suitable for the scale-up and subsequent commercialization of tissue engineered products should ideally be cost effective and accessible. For the in vitro culture of certain adherent cells, synthetic fabrication techniques are often employed to produce micro- or nano-patterned substrates to influence cell attachment, morphology, and alignment via the mechanism of contact guidance. Here we present a natural scaffold, in the form of decellularized amenity grass, which retains its natural striated topography and suppo...
Source: Biomed Res - May 31, 2021 Category: Research Authors: Scott J Allan Marianne J Ellis Paul A De Bank Source Type: research

Tomographic Evaluation of the Internal Adaptation for Recent Calcium Silicate-Based Pulp Capping Materials in Primary Teeth
Biomed Res Int. 2021 May 8;2021:5523145. doi: 10.1155/2021/5523145. eCollection 2021.ABSTRACTOBJECTIVES: To evaluate the internal adaptation of recent pulp capping materials (TheraCal and Biodentine) relative to MTA when used as indirect pulp capping for primary teeth.MATERIALS AND METHODS: Thirty primary molars were randomly allocated into three groups, group (A) was TheraCal, group (B) was Biodentine, and MTA was the control group (C). A standardized round class-V cavity (1.5 mm diameter and 2 mm depth) was prepared using a milling machine on the buccal surface of each tooth with the pulpal floor located on the dentin. T...
Source: Biomed Res - May 28, 2021 Category: Research Authors: A A Al Tuwirqi E A El Ashiry A Y Alzahrani N Bamashmous T A Bakhsh Source Type: research

< em > In Silico < /em > Structural, Functional, and Phylogenetic Analysis of Cytochrome (CYPD) Protein Family
Biomed Res Int. 2021 May 10;2021:5574789. doi: 10.1155/2021/5574789. eCollection 2021.ABSTRACTCytochrome (CYP) enzymes catalyze the metabolic reactions of endogenous and exogenous compounds. The superfamily of enzymes is found across many organisms, regardless of type, except for plants. Information was gathered about CYP2D enzymes through protein sequences of humans and other organisms. The secondary structure was predicted using the SOPMA. The structural and functional study of human CYP2D was conducted using ProtParam, SOPMA, Predotar 1.03, SignalP, TMHMM 2.0, and ExPASy. Most animals shared five central motifs accordin...
Source: Biomed Res - May 28, 2021 Category: Research Authors: Hafiz Ishfaq Ahmad Gulnaz Afzal Adil Jamal Shumaila Kiran Musarrat Abbas Khan Khalid Mehmood Zahid Kamran Irfan Ahmed Shakeel Ahmad Asmar Ahmad Javed Hussain Sadaf Almas Source Type: research

Periodontal Clinical Parameters as a Predictor of Bite Force: A Cross-Sectional Study
CONCLUSION: Among all periodontal clinical parameters, the percentage of remaining alveolar bone is the strong predictor of bite force and mobility; attachment loss and gingival recession cannot predict the bite force in the first molar region. Bite force is variable in different stages of periodontitis.PMID:34046498 | PMC:PMC8128538 | DOI:10.1155/2021/5582946 (Source: Biomed Res)
Source: Biomed Res - May 28, 2021 Category: Research Authors: Hussain Nayef Hussain Alsharif Kiran Kumar Ganji Mohammad Khursheed Alam Srinivas Munisekhar Manay Vinod Bandela Mohammed Ghazi Sghaireen Mohammed Assayed Mousa Source Type: research

Epidemiological Survey of < em > Mycoplasma bovis < /em > in Yaks on the Qinghai Tibetan Plateau, China
Biomed Res Int. 2021 Apr 14;2021:6646664. doi: 10.1155/2021/6646664. eCollection 2021.ABSTRACTMycoplasma bovis (M. bovis) is one of the most important pneumonia pathogens in yaks. It may result in more economic losses due to the cold and anoxia condition at Qinghai Tibetan plateau. However, to date, limited information on M. bovis infection in yaks is available in China. For this purpose, the seroprevalence of M. bovis was investigated in yaks living in the mentioned area through commercial ELISA kits. A total of 959 yaks were incorporated into this study. The prevalence of the disease in yaks was 48.70%. The serological r...
Source: Biomed Res - May 28, 2021 Category: Research Authors: Jiaqiang Niu Keiwei Li Huachun Pan Xing Gao Jiakui Li Dongjing Wang Mingshuai Yan Yefen Xu Suolang Sizhu Source Type: research

Noyes-Whitney Dissolution Model-Based pH-Sensitive Slow Release of Paclitaxel (Taxol) from Human Hair-Derived Keratin Microparticle Carriers
Biomed Res Int. 2021 May 7;2021:6657482. doi: 10.1155/2021/6657482. eCollection 2021.ABSTRACTThis paper describes a convenient and straightforward method developed to extract keratin particles (KPs) from human hair. It also involves their characterization by several methods and encapsulation of the anticancer drug Paclitaxel (Taxol) within them, aiming for targeted delivery to cancerous sites and slow release at their vicinity. The KPs obtained were in micrometer in size. They are capable of encapsulating Taxol within them with a high encapsulation efficiency of 56% and a drug loading capacity of 2.360 g of Taxol per g ker...
Source: Biomed Res - May 28, 2021 Category: Research Authors: V W Wimalasiri S P Dunuweera A N Dunuweera R M G Rajapakse Source Type: research

The Effect of Stromal-Derived Factor 1 < em > α < /em > on Osteoinduction Properties of Porous < em > β < /em > -Tricalcium Phosphate Bioceramics
In conclusion, SDF-1α/TCP bioceramic scaffolds could further promote bone regeneration compared to pure TCP bioceramics.PMID:34046501 | PMC:PMC8128615 | DOI:10.1155/2021/8882355 (Source: Biomed Res)
Source: Biomed Res - May 28, 2021 Category: Research Authors: Fangchun Jin Qixun Cai Wei Wang Xiaohui Fan Xiao Lu Ning He Jing Ding Source Type: research

Effects and Anti-rotation Stabilization of the Non-bridging External Fixation for Pronation-Abduction Stage III Ankle Fracture: A Cadaveric Study
This study is aimed at providing a nonbridging external fixation technique with pinning fixation for the pronation-abduction stage III ankle fracture. The secondary purpose was to evaluate its effect on anatomic reduction and fracture fragment stability against cadaveric models' rotation.METHOD: A paired design study was conducted using 14 pairs of the cadaveric model which had been modeled for pronation-abduction stage III ankle fracture. One fracture model from each pair was randomly allocated to receive an open reduction and internal fixation, while the other was reduced and stabilized with the external fixation techniq...
Source: Biomed Res - May 28, 2021 Category: Research Authors: Yili Chen Xiaoyu Huang Yongzhong Cheng Jingjing Xu Yang Chen Qi Zhang Jianmin Wen Source Type: research

Review and Analysis of Two Gitelman Syndrome Pedigrees Complicated with Proteinuria or Hashimoto's Thyroiditis Caused by Compound Heterozygous < em > SLC12A3 < /em > Mutations
In this study, two GS families with proteinuria or Hashimoto's thyroiditis were analyzed for genetic-phenotypic association. Sanger sequencing revealed that two probands carried SLC12A3 compound heterozygous mutations, and proband A carried two pathogenic mutations: missense mutation Arg83Gln, splicing mutation, or frameshift mutation NC_000016.10:g.56872655_56872667 (gcggacatttttg>accgaaaatttt) in exon 8. Proband B carries two missense mutations: novel Asp839Val and Arg904Gln. Both probands manifested hypokalemia, hypomagnesemia, hypocalcinuria, metabolic alkalosis, and RAAS activation; in addition, the proband A exhib...
Source: Biomed Res - May 28, 2021 Category: Research Authors: Jian-Hui Zhang Dan-Dan Ruan Ya-Nan Hu Xing-Lin Ruan Yao-Bin Zhu Xiao Yang Jia-Bin Wu Xin-Fu Lin Jie-Wei Luo Fa-Qiang Tang Source Type: research

Tomographic Evaluation of the Internal Adaptation for Recent Calcium Silicate-Based Pulp Capping Materials in Primary Teeth
Biomed Res Int. 2021 May 8;2021:5523145. doi: 10.1155/2021/5523145. eCollection 2021.ABSTRACTOBJECTIVES: To evaluate the internal adaptation of recent pulp capping materials (TheraCal and Biodentine) relative to MTA when used as indirect pulp capping for primary teeth.MATERIALS AND METHODS: Thirty primary molars were randomly allocated into three groups, group (A) was TheraCal, group (B) was Biodentine, and MTA was the control group (C). A standardized round class-V cavity (1.5 mm diameter and 2 mm depth) was prepared using a milling machine on the buccal surface of each tooth with the pulpal floor located on the dentin. T...
Source: Biomed Res - May 28, 2021 Category: Research Authors: A A Al Tuwirqi E A El Ashiry A Y Alzahrani N Bamashmous T A Bakhsh Source Type: research

< em > In Silico < /em > Structural, Functional, and Phylogenetic Analysis of Cytochrome (CYPD) Protein Family
Biomed Res Int. 2021 May 10;2021:5574789. doi: 10.1155/2021/5574789. eCollection 2021.ABSTRACTCytochrome (CYP) enzymes catalyze the metabolic reactions of endogenous and exogenous compounds. The superfamily of enzymes is found across many organisms, regardless of type, except for plants. Information was gathered about CYP2D enzymes through protein sequences of humans and other organisms. The secondary structure was predicted using the SOPMA. The structural and functional study of human CYP2D was conducted using ProtParam, SOPMA, Predotar 1.03, SignalP, TMHMM 2.0, and ExPASy. Most animals shared five central motifs accordin...
Source: Biomed Res - May 28, 2021 Category: Research Authors: Hafiz Ishfaq Ahmad Gulnaz Afzal Adil Jamal Shumaila Kiran Musarrat Abbas Khan Khalid Mehmood Zahid Kamran Irfan Ahmed Shakeel Ahmad Asmar Ahmad Javed Hussain Sadaf Almas Source Type: research

Periodontal Clinical Parameters as a Predictor of Bite Force: A Cross-Sectional Study
CONCLUSION: Among all periodontal clinical parameters, the percentage of remaining alveolar bone is the strong predictor of bite force and mobility; attachment loss and gingival recession cannot predict the bite force in the first molar region. Bite force is variable in different stages of periodontitis.PMID:34046498 | PMC:PMC8128538 | DOI:10.1155/2021/5582946 (Source: Biomed Res)
Source: Biomed Res - May 28, 2021 Category: Research Authors: Hussain Nayef Hussain Alsharif Kiran Kumar Ganji Mohammad Khursheed Alam Srinivas Munisekhar Manay Vinod Bandela Mohammed Ghazi Sghaireen Mohammed Assayed Mousa Source Type: research

Epidemiological Survey of < em > Mycoplasma bovis < /em > in Yaks on the Qinghai Tibetan Plateau, China
Biomed Res Int. 2021 Apr 14;2021:6646664. doi: 10.1155/2021/6646664. eCollection 2021.ABSTRACTMycoplasma bovis (M. bovis) is one of the most important pneumonia pathogens in yaks. It may result in more economic losses due to the cold and anoxia condition at Qinghai Tibetan plateau. However, to date, limited information on M. bovis infection in yaks is available in China. For this purpose, the seroprevalence of M. bovis was investigated in yaks living in the mentioned area through commercial ELISA kits. A total of 959 yaks were incorporated into this study. The prevalence of the disease in yaks was 48.70%. The serological r...
Source: Biomed Res - May 28, 2021 Category: Research Authors: Jiaqiang Niu Keiwei Li Huachun Pan Xing Gao Jiakui Li Dongjing Wang Mingshuai Yan Yefen Xu Suolang Sizhu Source Type: research

Noyes-Whitney Dissolution Model-Based pH-Sensitive Slow Release of Paclitaxel (Taxol) from Human Hair-Derived Keratin Microparticle Carriers
Biomed Res Int. 2021 May 7;2021:6657482. doi: 10.1155/2021/6657482. eCollection 2021.ABSTRACTThis paper describes a convenient and straightforward method developed to extract keratin particles (KPs) from human hair. It also involves their characterization by several methods and encapsulation of the anticancer drug Paclitaxel (Taxol) within them, aiming for targeted delivery to cancerous sites and slow release at their vicinity. The KPs obtained were in micrometer in size. They are capable of encapsulating Taxol within them with a high encapsulation efficiency of 56% and a drug loading capacity of 2.360 g of Taxol per g ker...
Source: Biomed Res - May 28, 2021 Category: Research Authors: V W Wimalasiri S P Dunuweera A N Dunuweera R M G Rajapakse Source Type: research

The Effect of Stromal-Derived Factor 1 < em > α < /em > on Osteoinduction Properties of Porous < em > β < /em > -Tricalcium Phosphate Bioceramics
In conclusion, SDF-1α/TCP bioceramic scaffolds could further promote bone regeneration compared to pure TCP bioceramics.PMID:34046501 | PMC:PMC8128615 | DOI:10.1155/2021/8882355 (Source: Biomed Res)
Source: Biomed Res - May 28, 2021 Category: Research Authors: Fangchun Jin Qixun Cai Wei Wang Xiaohui Fan Xiao Lu Ning He Jing Ding Source Type: research

Effects and Anti-rotation Stabilization of the Non-bridging External Fixation for Pronation-Abduction Stage III Ankle Fracture: A Cadaveric Study
This study is aimed at providing a nonbridging external fixation technique with pinning fixation for the pronation-abduction stage III ankle fracture. The secondary purpose was to evaluate its effect on anatomic reduction and fracture fragment stability against cadaveric models' rotation.METHOD: A paired design study was conducted using 14 pairs of the cadaveric model which had been modeled for pronation-abduction stage III ankle fracture. One fracture model from each pair was randomly allocated to receive an open reduction and internal fixation, while the other was reduced and stabilized with the external fixation techniq...
Source: Biomed Res - May 28, 2021 Category: Research Authors: Yili Chen Xiaoyu Huang Yongzhong Cheng Jingjing Xu Yang Chen Qi Zhang Jianmin Wen Source Type: research

Review and Analysis of Two Gitelman Syndrome Pedigrees Complicated with Proteinuria or Hashimoto's Thyroiditis Caused by Compound Heterozygous < em > SLC12A3 < /em > Mutations
In this study, two GS families with proteinuria or Hashimoto's thyroiditis were analyzed for genetic-phenotypic association. Sanger sequencing revealed that two probands carried SLC12A3 compound heterozygous mutations, and proband A carried two pathogenic mutations: missense mutation Arg83Gln, splicing mutation, or frameshift mutation NC_000016.10:g.56872655_56872667 (gcggacatttttg>accgaaaatttt) in exon 8. Proband B carries two missense mutations: novel Asp839Val and Arg904Gln. Both probands manifested hypokalemia, hypomagnesemia, hypocalcinuria, metabolic alkalosis, and RAAS activation; in addition, the proband A exhib...
Source: Biomed Res - May 28, 2021 Category: Research Authors: Jian-Hui Zhang Dan-Dan Ruan Ya-Nan Hu Xing-Lin Ruan Yao-Bin Zhu Xiao Yang Jia-Bin Wu Xin-Fu Lin Jie-Wei Luo Fa-Qiang Tang Source Type: research

Tomographic Evaluation of the Internal Adaptation for Recent Calcium Silicate-Based Pulp Capping Materials in Primary Teeth
Biomed Res Int. 2021 May 8;2021:5523145. doi: 10.1155/2021/5523145. eCollection 2021.ABSTRACTOBJECTIVES: To evaluate the internal adaptation of recent pulp capping materials (TheraCal and Biodentine) relative to MTA when used as indirect pulp capping for primary teeth.MATERIALS AND METHODS: Thirty primary molars were randomly allocated into three groups, group (A) was TheraCal, group (B) was Biodentine, and MTA was the control group (C). A standardized round class-V cavity (1.5 mm diameter and 2 mm depth) was prepared using a milling machine on the buccal surface of each tooth with the pulpal floor located on the dentin. T...
Source: Biomed Res - May 28, 2021 Category: Research Authors: A A Al Tuwirqi E A El Ashiry A Y Alzahrani N Bamashmous T A Bakhsh Source Type: research

< em > In Silico < /em > Structural, Functional, and Phylogenetic Analysis of Cytochrome (CYPD) Protein Family
Biomed Res Int. 2021 May 10;2021:5574789. doi: 10.1155/2021/5574789. eCollection 2021.ABSTRACTCytochrome (CYP) enzymes catalyze the metabolic reactions of endogenous and exogenous compounds. The superfamily of enzymes is found across many organisms, regardless of type, except for plants. Information was gathered about CYP2D enzymes through protein sequences of humans and other organisms. The secondary structure was predicted using the SOPMA. The structural and functional study of human CYP2D was conducted using ProtParam, SOPMA, Predotar 1.03, SignalP, TMHMM 2.0, and ExPASy. Most animals shared five central motifs accordin...
Source: Biomed Res - May 28, 2021 Category: Research Authors: Hafiz Ishfaq Ahmad Gulnaz Afzal Adil Jamal Shumaila Kiran Musarrat Abbas Khan Khalid Mehmood Zahid Kamran Irfan Ahmed Shakeel Ahmad Asmar Ahmad Javed Hussain Sadaf Almas Source Type: research

Periodontal Clinical Parameters as a Predictor of Bite Force: A Cross-Sectional Study
CONCLUSION: Among all periodontal clinical parameters, the percentage of remaining alveolar bone is the strong predictor of bite force and mobility; attachment loss and gingival recession cannot predict the bite force in the first molar region. Bite force is variable in different stages of periodontitis.PMID:34046498 | PMC:PMC8128538 | DOI:10.1155/2021/5582946 (Source: Biomed Res)
Source: Biomed Res - May 28, 2021 Category: Research Authors: Hussain Nayef Hussain Alsharif Kiran Kumar Ganji Mohammad Khursheed Alam Srinivas Munisekhar Manay Vinod Bandela Mohammed Ghazi Sghaireen Mohammed Assayed Mousa Source Type: research

Epidemiological Survey of < em > Mycoplasma bovis < /em > in Yaks on the Qinghai Tibetan Plateau, China
Biomed Res Int. 2021 Apr 14;2021:6646664. doi: 10.1155/2021/6646664. eCollection 2021.ABSTRACTMycoplasma bovis (M. bovis) is one of the most important pneumonia pathogens in yaks. It may result in more economic losses due to the cold and anoxia condition at Qinghai Tibetan plateau. However, to date, limited information on M. bovis infection in yaks is available in China. For this purpose, the seroprevalence of M. bovis was investigated in yaks living in the mentioned area through commercial ELISA kits. A total of 959 yaks were incorporated into this study. The prevalence of the disease in yaks was 48.70%. The serological r...
Source: Biomed Res - May 28, 2021 Category: Research Authors: Jiaqiang Niu Keiwei Li Huachun Pan Xing Gao Jiakui Li Dongjing Wang Mingshuai Yan Yefen Xu Suolang Sizhu Source Type: research

Noyes-Whitney Dissolution Model-Based pH-Sensitive Slow Release of Paclitaxel (Taxol) from Human Hair-Derived Keratin Microparticle Carriers
Biomed Res Int. 2021 May 7;2021:6657482. doi: 10.1155/2021/6657482. eCollection 2021.ABSTRACTThis paper describes a convenient and straightforward method developed to extract keratin particles (KPs) from human hair. It also involves their characterization by several methods and encapsulation of the anticancer drug Paclitaxel (Taxol) within them, aiming for targeted delivery to cancerous sites and slow release at their vicinity. The KPs obtained were in micrometer in size. They are capable of encapsulating Taxol within them with a high encapsulation efficiency of 56% and a drug loading capacity of 2.360 g of Taxol per g ker...
Source: Biomed Res - May 28, 2021 Category: Research Authors: V W Wimalasiri S P Dunuweera A N Dunuweera R M G Rajapakse Source Type: research

The Effect of Stromal-Derived Factor 1 < em > α < /em > on Osteoinduction Properties of Porous < em > β < /em > -Tricalcium Phosphate Bioceramics
In conclusion, SDF-1α/TCP bioceramic scaffolds could further promote bone regeneration compared to pure TCP bioceramics.PMID:34046501 | PMC:PMC8128615 | DOI:10.1155/2021/8882355 (Source: Biomed Res)
Source: Biomed Res - May 28, 2021 Category: Research Authors: Fangchun Jin Qixun Cai Wei Wang Xiaohui Fan Xiao Lu Ning He Jing Ding Source Type: research

Effects and Anti-rotation Stabilization of the Non-bridging External Fixation for Pronation-Abduction Stage III Ankle Fracture: A Cadaveric Study
This study is aimed at providing a nonbridging external fixation technique with pinning fixation for the pronation-abduction stage III ankle fracture. The secondary purpose was to evaluate its effect on anatomic reduction and fracture fragment stability against cadaveric models' rotation.METHOD: A paired design study was conducted using 14 pairs of the cadaveric model which had been modeled for pronation-abduction stage III ankle fracture. One fracture model from each pair was randomly allocated to receive an open reduction and internal fixation, while the other was reduced and stabilized with the external fixation techniq...
Source: Biomed Res - May 28, 2021 Category: Research Authors: Yili Chen Xiaoyu Huang Yongzhong Cheng Jingjing Xu Yang Chen Qi Zhang Jianmin Wen Source Type: research

Review and Analysis of Two Gitelman Syndrome Pedigrees Complicated with Proteinuria or Hashimoto's Thyroiditis Caused by Compound Heterozygous < em > SLC12A3 < /em > Mutations
In this study, two GS families with proteinuria or Hashimoto's thyroiditis were analyzed for genetic-phenotypic association. Sanger sequencing revealed that two probands carried SLC12A3 compound heterozygous mutations, and proband A carried two pathogenic mutations: missense mutation Arg83Gln, splicing mutation, or frameshift mutation NC_000016.10:g.56872655_56872667 (gcggacatttttg>accgaaaatttt) in exon 8. Proband B carries two missense mutations: novel Asp839Val and Arg904Gln. Both probands manifested hypokalemia, hypomagnesemia, hypocalcinuria, metabolic alkalosis, and RAAS activation; in addition, the proband A exhib...
Source: Biomed Res - May 28, 2021 Category: Research Authors: Jian-Hui Zhang Dan-Dan Ruan Ya-Nan Hu Xing-Lin Ruan Yao-Bin Zhu Xiao Yang Jia-Bin Wu Xin-Fu Lin Jie-Wei Luo Fa-Qiang Tang Source Type: research

Recovery from COVID-19: a sprint or marathon? 6-month follow-up data from online long COVID-19 support group members
ERJ Open Res. 2021 May 24;7(2):00141-2021. doi: 10.1183/23120541.00141-2021. eCollection 2021 Apr.ABSTRACTBACKGROUND: It remains unknown whether and to what extent members of online "long COVID" peer support groups remain symptomatic and limited over time. Therefore, we aimed to evaluate symptoms in members of online long COVID peer support groups up to 6 months after the onset of coronavirus disease 2019 (COVID-19)-related symptoms.METHODS: Demographics, symptoms, health status, work productivity, functional status and health-related quality of life were assessed about 3 and 6 months after the onset of COVID-19-...
Source: Biomed Res - May 27, 2021 Category: Research Authors: Anouk W Vaes Yvonne M J Go ërtz Maarten Van Herck Felipe V C Machado Roy Meys Jeannet M Delbressine Sarah Houben-Wilke Swetlana Gaffron Dieter Maier Chris Burtin Rein Posthuma Nicole P H van Loon Frits M E Franssen Bita Hajian Sami O Simons Job F M van B Source Type: research

Chemometric Analysis of UV-Visible Spectral Fingerprints for the Discrimination and Quantification of Clinical Anthracycline Drug Preparation Used in Oncology
This study demonstrated the viability of UV-visible fingerprinting (routine approach) coupled with chemometric tools for the classification and quantification of chemotherapeutic drugs during clinical preparation.PMID:34041297 | PMC:PMC8121585 | DOI:10.1155/2021/5580102 (Source: Biomed Res)
Source: Biomed Res - May 27, 2021 Category: Research Authors: Aimen El Orche Casimir Adade Adade Hafid Mefetah Amine Cheikh Khalid Karrouchi Miloud El Karbane Mustapha Bouatia Source Type: research

Enhanced Neurokinin-1 Receptor Expression Is Associated with Human Dental Pulp Inflammation and Pain Severity
Biomed Res Int. 2021 May 5;2021:5593520. doi: 10.1155/2021/5593520. eCollection 2021.ABSTRACTSubstance P (SP) is a peptide involved in many biological processes, including nociception and inflammation. SP has a high affinity for its receptor neurokinin-1 (NK-1R). SP/NK-1R complex plays a major role in the interactions going on during the onset of dental pain and inflammation. Objective. To identify the expression of NK-1R in healthy and inflamed human dental pulp, as well as to identify any association with severity of dental pain. Methods. This case-control study included ten irreversibly inflamed samples of dental pulp, ...
Source: Biomed Res - May 27, 2021 Category: Research Authors: Riffat Mehboob Sana Hassan Syed Amir Gilani Amber Hassan Imrana Tanvir Humaira Waseem Asif Hanif Source Type: research

Impact of Albendazole on Cytokine and Chemokine Response Profiles in < em > Echinococcus multilocularis < /em > -Inoculated Mice
Biomed Res Int. 2021 May 7;2021:6628814. doi: 10.1155/2021/6628814. eCollection 2021.ABSTRACTOBJECTIVE: Alveolar echinococcosis (AE) is a zoonosis caused by the larval stage of the metacestode Echinococcosis multilocularis with a tumor-like behavior in the targeted organ, especially in the liver. Surgery with albendazole is first-line modality for AE. Drug discontinuation is usually based upon the parasitic viability shown by the positron emission tomography (PET) scan. However, as a demanding and expensive method, it is not widely practiced in majority of the endemic regions. Further understanding on the cytokine and chem...
Source: Biomed Res - May 27, 2021 Category: Research Authors: Jing Wu Hai-Zhang Ma Shadike Apaer Nuerzatijiang Anweier Qi Zeng Xiafukati Fulati Tao Li Jin-Ming Zhao Hao Wen Tuerhongjiang Tuxun Source Type: research

The Magnitude of Wasting and Associated Factors among Children Aged 2-5 Years in Southern Ethiopia: A Cross-Sectional Study
CONCLUSION: Undernutrition in children is still a problem, and the proportion of wasting was 13%. Government-employed fathers, child's age range between 48 and 59 months, being a male child, having diarrheal disease in the past two weeks, and bathing below two times per week were significantly associated with children's nutritional status warranting close attention by policymakers and stakeholders. For researchers, a further longitudinal study is recommended to get strong evidence.PMID:34041300 | PMC:PMC8121579 | DOI:10.1155/2021/6645996 (Source: Biomed Res)
Source: Biomed Res - May 27, 2021 Category: Research Authors: Selamawit Dires Moges Mareg Source Type: research

Analysis of Prevalence and Risk Factors of Contact Sensitization with respect to the Occupational Profiles in a Greek Patient Cohort: A Retrospective Analysis of a Greek Referral Centre and Future Perspectives
Biomed Res Int. 2021 May 6;2021:6672506. doi: 10.1155/2021/6672506. eCollection 2021.ABSTRACTContact dermatitis is a frequent skin disorder related to environmental and occupational etiological factors, which could potentially affect all age groups, as well as both genders. The current study is aimed at exploring the patterns of contact sensitization with respect to the population's occupational patterns in Greece. A retrospective analysis was performed in a cohort of 1978 patients from 2014 to 2016. Patients were divided into two categories; blue collars (BlC) and white collars (WhC), as well as detailed occupation was co...
Source: Biomed Res - May 27, 2021 Category: Research Authors: Anna Tagka George I Lambrou George K Matsopoulos Despoina Fytili Daphne Mirkopoulou Alexandra Katsarou Argyro Chatziioannou Alexandros Stratigos Source Type: research

Promoting endogenous repair of skeletal muscle using regenerative biomaterials
J Biomed Mater Res A. 2021 May 26. doi: 10.1002/jbm.a.37239. Online ahead of print.ABSTRACTSkeletal muscles normally have a remarkable ability to repair themselves; however, large muscle injuries and several myopathies diminish this ability leading to permanent loss of function. No clinical therapy yet exists that reliably restores muscle integrity and function following severe injury. Consequently, numerous tissue engineering techniques, both acellular and with cells, are being investigated to enhance muscle regeneration. Biomaterials are an essential part of these techniques as they can present physical and biochemical s...
Source: Biomed Res - May 27, 2021 Category: Research Authors: Miranda M Carleton Michael V Sefton Source Type: research

Recovery from COVID-19: a sprint or marathon? 6-month follow-up data from online long COVID-19 support group members
ERJ Open Res. 2021 May 24;7(2):00141-2021. doi: 10.1183/23120541.00141-2021. eCollection 2021 Apr.ABSTRACTBACKGROUND: It remains unknown whether and to what extent members of online "long COVID" peer support groups remain symptomatic and limited over time. Therefore, we aimed to evaluate symptoms in members of online long COVID peer support groups up to 6 months after the onset of coronavirus disease 2019 (COVID-19)-related symptoms.METHODS: Demographics, symptoms, health status, work productivity, functional status and health-related quality of life were assessed about 3 and 6 months after the onset of COVID-19-...
Source: Biomed Res - May 27, 2021 Category: Research Authors: Anouk W Vaes Yvonne M J Go ërtz Maarten Van Herck Felipe V C Machado Roy Meys Jeannet M Delbressine Sarah Houben-Wilke Swetlana Gaffron Dieter Maier Chris Burtin Rein Posthuma Nicole P H van Loon Frits M E Franssen Bita Hajian Sami O Simons Job F M van B Source Type: research

Chemometric Analysis of UV-Visible Spectral Fingerprints for the Discrimination and Quantification of Clinical Anthracycline Drug Preparation Used in Oncology
This study demonstrated the viability of UV-visible fingerprinting (routine approach) coupled with chemometric tools for the classification and quantification of chemotherapeutic drugs during clinical preparation.PMID:34041297 | PMC:PMC8121585 | DOI:10.1155/2021/5580102 (Source: Biomed Res)
Source: Biomed Res - May 27, 2021 Category: Research Authors: Aimen El Orche Casimir Adade Adade Hafid Mefetah Amine Cheikh Khalid Karrouchi Miloud El Karbane Mustapha Bouatia Source Type: research

Enhanced Neurokinin-1 Receptor Expression Is Associated with Human Dental Pulp Inflammation and Pain Severity
Biomed Res Int. 2021 May 5;2021:5593520. doi: 10.1155/2021/5593520. eCollection 2021.ABSTRACTSubstance P (SP) is a peptide involved in many biological processes, including nociception and inflammation. SP has a high affinity for its receptor neurokinin-1 (NK-1R). SP/NK-1R complex plays a major role in the interactions going on during the onset of dental pain and inflammation. Objective. To identify the expression of NK-1R in healthy and inflamed human dental pulp, as well as to identify any association with severity of dental pain. Methods. This case-control study included ten irreversibly inflamed samples of dental pulp, ...
Source: Biomed Res - May 27, 2021 Category: Research Authors: Riffat Mehboob Sana Hassan Syed Amir Gilani Amber Hassan Imrana Tanvir Humaira Waseem Asif Hanif Source Type: research

Impact of Albendazole on Cytokine and Chemokine Response Profiles in < em > Echinococcus multilocularis < /em > -Inoculated Mice
Biomed Res Int. 2021 May 7;2021:6628814. doi: 10.1155/2021/6628814. eCollection 2021.ABSTRACTOBJECTIVE: Alveolar echinococcosis (AE) is a zoonosis caused by the larval stage of the metacestode Echinococcosis multilocularis with a tumor-like behavior in the targeted organ, especially in the liver. Surgery with albendazole is first-line modality for AE. Drug discontinuation is usually based upon the parasitic viability shown by the positron emission tomography (PET) scan. However, as a demanding and expensive method, it is not widely practiced in majority of the endemic regions. Further understanding on the cytokine and chem...
Source: Biomed Res - May 27, 2021 Category: Research Authors: Jing Wu Hai-Zhang Ma Shadike Apaer Nuerzatijiang Anweier Qi Zeng Xiafukati Fulati Tao Li Jin-Ming Zhao Hao Wen Tuerhongjiang Tuxun Source Type: research

The Magnitude of Wasting and Associated Factors among Children Aged 2-5 Years in Southern Ethiopia: A Cross-Sectional Study
CONCLUSION: Undernutrition in children is still a problem, and the proportion of wasting was 13%. Government-employed fathers, child's age range between 48 and 59 months, being a male child, having diarrheal disease in the past two weeks, and bathing below two times per week were significantly associated with children's nutritional status warranting close attention by policymakers and stakeholders. For researchers, a further longitudinal study is recommended to get strong evidence.PMID:34041300 | PMC:PMC8121579 | DOI:10.1155/2021/6645996 (Source: Biomed Res)
Source: Biomed Res - May 27, 2021 Category: Research Authors: Selamawit Dires Moges Mareg Source Type: research

Analysis of Prevalence and Risk Factors of Contact Sensitization with respect to the Occupational Profiles in a Greek Patient Cohort: A Retrospective Analysis of a Greek Referral Centre and Future Perspectives
Biomed Res Int. 2021 May 6;2021:6672506. doi: 10.1155/2021/6672506. eCollection 2021.ABSTRACTContact dermatitis is a frequent skin disorder related to environmental and occupational etiological factors, which could potentially affect all age groups, as well as both genders. The current study is aimed at exploring the patterns of contact sensitization with respect to the population's occupational patterns in Greece. A retrospective analysis was performed in a cohort of 1978 patients from 2014 to 2016. Patients were divided into two categories; blue collars (BlC) and white collars (WhC), as well as detailed occupation was co...
Source: Biomed Res - May 27, 2021 Category: Research Authors: Anna Tagka George I Lambrou George K Matsopoulos Despoina Fytili Daphne Mirkopoulou Alexandra Katsarou Argyro Chatziioannou Alexandros Stratigos Source Type: research

Promoting endogenous repair of skeletal muscle using regenerative biomaterials
J Biomed Mater Res A. 2021 May 26. doi: 10.1002/jbm.a.37239. Online ahead of print.ABSTRACTSkeletal muscles normally have a remarkable ability to repair themselves; however, large muscle injuries and several myopathies diminish this ability leading to permanent loss of function. No clinical therapy yet exists that reliably restores muscle integrity and function following severe injury. Consequently, numerous tissue engineering techniques, both acellular and with cells, are being investigated to enhance muscle regeneration. Biomaterials are an essential part of these techniques as they can present physical and biochemical s...
Source: Biomed Res - May 27, 2021 Category: Research Authors: Miranda M Carleton Michael V Sefton Source Type: research

Tailored Therapy Based on Molecular Characteristics in Endometrial Cancer
Biomed Res Int. 2021 May 5;2021:2068023. doi: 10.1155/2021/2068023. eCollection 2021.ABSTRACTManagement of endometrial cancer, an adenocarcinoma of the endometrium which occupies most uterine corpus neoplasms, including uterine sarcomas, has been more relevant due to its increasing incidence. Extensive research on tumorigenesis molecular mechanisms and molecular characterization across cancers has brought paradigm shifts in the treatment of various malignant tumors. Endometrial cancer treatment has been traditionally guided according to the disease extent or histology types, while recent studies on molecular features have ...
Source: Biomed Res - May 26, 2021 Category: Research Authors: Suk-Young Lee Source Type: research

The Role of Anesthetic Selection in Perioperative Bleeding
Biomed Res Int. 2021 May 7;2021:5510634. doi: 10.1155/2021/5510634. eCollection 2021.ABSTRACTPerioperative bleeding is one of the major comorbidities associated with surgery. While anesthesia is a critical component to perform surgery, a number of clinical studies supported the contribution of anesthetic drugs to perioperative bleeding. Here, we reviewed the literature on this topic including the underlying mechanism and discussed the future direction on coagulation research in anesthesia.PMID:34036098 | PMC:PMC8123995 | DOI:10.1155/2021/5510634 (Source: Biomed Res)
Source: Biomed Res - May 26, 2021 Category: Research Authors: Koichi Yuki James A DiNardo Sophia Koutsogiannaki Source Type: research

Effect of Nd:YAG, Er,Cr:YSGG Laser Irradiation, and Adjunctive Photodynamic Therapy on Push-Out Bond Strength of Zirconia Posts to Radicular Dentin
This study is aimed at assessing the influence of Nd:YAG, Er,Cr:YSGG laser irradiation, and adjunctive photodynamic therapy (aPDT) on the bond strength of zirconia posts to radicular dentin. Eighty extracted anterior teeth were randomly categorized into 4 groups (n = 20) based on varying laser irradiation treatments, i.e., conventional cleaning and shaping (CCS), Nd:YAG, Er,Cr:YSGG, and aPDT group, respectively. Using a cutting machine, the samples were prepared for push-out bond strength analysis; 4 sections (2 on each apical and cervical) of around 1 mm thickness were sectioned for all roots at a right angle to the long ...
Source: Biomed Res - May 26, 2021 Category: Research Authors: Freah Alshammary Mohmed I Karobari Ali A Assiry Anand Marya Gul M Shaikh Ammar A Siddiqui Mohammad K Alam Source Type: research

Medicinal Plants with Prospective Benefits in the Management of Peptic Ulcer Diseases in Ghana
Conclusion. A discussion of various antiulcer activity studies using ulcer models carried out on selected medicinal plants used for the management of peptic ulcer disease in addition to brief information on their folkloric uses and their phytochemical and other pharmacological properties is presented. These medicinal plants may be used in developing herbal products for the management of peptic ulcer disease.PMID:34036100 | PMC:PMC8118747 | DOI:10.1155/2021/5574041 (Source: Biomed Res)
Source: Biomed Res - May 26, 2021 Category: Research Authors: Mavis Boakye-Yiadom Doris Kumadoh Emmanuel Adase Eric Woode Source Type: research

A Novel Review of Homocysteine and Pregnancy Complications
Biomed Res Int. 2021 May 6;2021:6652231. doi: 10.1155/2021/6652231. eCollection 2021.ABSTRACTHomocysteine (Hct) is a substance produced in the metabolism of methionine. It is an essential type of amino acid gained from the daily diet. Methylenetetrahydrofolate reductase (MTHFR) gene mutation is related to elevated total homocysteine (tHct) expressions, in particular, among women with low folate intake. Hyperhomocysteinemia (HHct) is caused by numerous factors, such as genetic defects, lack of folic acid, vitamin B6 and B12 deficiency, hypothyroidism, drugs, aging, and renal dysfunction. Increased Hct in peripheral blood ma...
Source: Biomed Res - May 26, 2021 Category: Research Authors: Chuce Dai Yiming Fei Jianming Li Yang Shi Xiuhua Yang Source Type: research

Abnormal Expression and Prognostic Significance of Bone Morphogenetic Proteins and Their Receptors in Lung Adenocarcinoma
CONCLUSIONS: BMP5, BMP7, and ACVR2A are potential therapeutic targets in LUAD. The three-gene prognostic model and the nomogram are reliable tools for predicting the OS of LUAD patients.PMID:34036102 | PMC:PMC8123996 | DOI:10.1155/2021/6663990 (Source: Biomed Res)
Source: Biomed Res - May 26, 2021 Category: Research Authors: Zhixiao Xu Chengshui Chen Source Type: research

Single Immunoglobulin IL-1-Related Receptor (SIGIRR) Gene rs7396562 Polymorphism and Expression Level in Rheumatoid Arthritis
CONCLUSIONS: Our findings demonstrated that the dysregulation of SIGIRR might be associated with the pathogenesis of RA, and SIGIRR rs7396562 polymorphism might contribute to RA susceptibility in the Chinese population.PMID:34036103 | PMC:PMC8124000 | DOI:10.1155/2021/6683148 (Source: Biomed Res)
Source: Biomed Res - May 26, 2021 Category: Research Authors: Xiaoke Yang Mingyue Zhang Shengqian Xu Haifeng Pan Ruixue Leng Zongwen Shuai Source Type: research

In Vivo and In Vitro Analyses of Titanium-Hydroxyapatite Functionally Graded Material for Dental Implants
CONCLUSION: Ti-HA FGM contributes to the osteogenesis of dental implants in vivo and in vitro.PMID:34036104 | PMC:PMC8121567 | DOI:10.1155/2021/8859945 (Source: Biomed Res)
Source: Biomed Res - May 26, 2021 Category: Research Authors: Xinhua Wang Chengpeng Wan Xiaoxia Feng Fuyan Zhao Huiming Wang Source Type: research