Single Immunoglobulin IL-1-Related Receptor (SIGIRR) Gene rs7396562 Polymorphism and Expression Level in Rheumatoid Arthritis
CONCLUSIONS: Our findings demonstrated that the dysregulation of SIGIRR might be associated with the pathogenesis of RA, and SIGIRR rs7396562 polymorphism might contribute to RA susceptibility in the Chinese population.PMID:34036103 | PMC:PMC8124000 | DOI:10.1155/2021/6683148 (Source: Biomed Res)
Source: Biomed Res - May 26, 2021 Category: Research Authors: Xiaoke Yang Mingyue Zhang Shengqian Xu Haifeng Pan Ruixue Leng Zongwen Shuai Source Type: research

In Vivo and In Vitro Analyses of Titanium-Hydroxyapatite Functionally Graded Material for Dental Implants
CONCLUSION: Ti-HA FGM contributes to the osteogenesis of dental implants in vivo and in vitro.PMID:34036104 | PMC:PMC8121567 | DOI:10.1155/2021/8859945 (Source: Biomed Res)
Source: Biomed Res - May 26, 2021 Category: Research Authors: Xinhua Wang Chengpeng Wan Xiaoxia Feng Fuyan Zhao Huiming Wang Source Type: research

Chromosome Abnormalities Related to Reproductive and Sexual Development Disorders: A 5-Year Retrospective Study
Biomed Res Int. 2021 May 5;2021:8893467. doi: 10.1155/2021/8893467. eCollection 2021.ABSTRACTChromosomal abnormalities are the main genetic risk factor associated with reproductive and sexual development disorders (DSD). The goal of this study is to retrospectively evaluate the frequency of chromosomal aberrations in Moroccan subjects with problems of procreation or sexual ambiguity. A total of 1005 individuals, including 170 infertile couples, underwent cytogenetic analysis in the Cytogenetic Laboratory of the Pasteur Institute of Morocco. Heparinized blood samples were processed according to the standard karyotype method...
Source: Biomed Res - May 26, 2021 Category: Research Authors: Sara Benchikh Amale Bousfiha Lunda Razoki Jamila Aboulfaraj Latifa Zarouf Chadli Elbakay Lala Laila Rifai Adil El Hamouchi Sanaa Nassereddine Source Type: research

The Potential Genes Mediate the Pathogenicity of Allogeneic CD4 < sup > + < /sup > T Cell in aGVHD Mouse Model
In this study, auto-HSCT and allo-HSCT aGVHD mouse models were built to detect the difference in CD4+ lymphocyte in different tissues based on ribonucleic acid sequencing (RNA-Seq) analysis. Clustering analysis, functional annotation, and pathway enrichment analysis were performed on differentially expressed genes (DEGs). The protein-protein interaction (PPI) network was used to find hub genes. CD4+T cells were activated by MLR and cytokine stimulation. Cells were sorted out by a flow cell sorter. The selected genes were verified by qRT-PCR, histology, and immunofluorescence staining. The GSE126518 GEO dataset was used to ...
Source: Biomed Res - May 26, 2021 Category: Research Authors: Zhengyu Yu Chenchen Qin Min Cao Xiaoya He Hanyun Ren Huihui Liu Source Type: research

Bioactive and biopassive treatment of poly(ethylene terephthalate) multifilament textile yarns to improve/prevent fibroblast viability
J Biomed Mater Res B Appl Biomater. 2021 May 26. doi: 10.1002/jbm.b.34882. Online ahead of print.ABSTRACTTo modulate the physicochemical features of poly(ethylene terephthalate) (PET) multifilaments surface composing a complex textile structure (core and shell system), intended to improve upon current implants for high extension injuries of the Achilles tendon or even for its total replacement, two surface treatments with different purposes (bioactive and biopassive) were studied. The first treatment is based on amino groups grafting using ethylenediamine molecules to be applied in the structure core to improve cell adhesi...
Source: Biomed Res - May 26, 2021 Category: Research Authors: Diana Santos Morais Miguel Azenha Rodrigues Cl áudia Lopes Filipe Vaz Liliana Grenho Maria Helena Fernandes Rui Miranda Guedes Maria Ascens ão Lopes Source Type: research

Findings of a Cross-Sectional Survey on Knowledge, Attitudes, and Practices about COVID-19 in Uganda: Implications for Public Health Prevention and Control Measures
CONCLUSIONS: This study shows that public health prevention efforts should be directed to closing the identified gaps in KAP among Ugandans in order to halt the spread of COVD-19 in Uganda as well as the East African region.PMID:34031643 | PMC:PMC7729389 | DOI:10.1155/2020/5917378 (Source: Biomed Res)
Source: Biomed Res - May 25, 2021 Category: Research Authors: Gerald Okello Jonathan Izudi Steven Teguzirigwa Allan Kakinda Guido Van Hal Source Type: research

3D printed hybrid bone constructs of PCL and dental pulp stem cells loaded GelMA
J Biomed Mater Res A. 2021 May 25. doi: 10.1002/jbm.a.37235. Online ahead of print.ABSTRACTFabrication of scaffolds using polymers and then cell seeding is a routine protocol of tissue engineering applications. Synthetic polymers have adequate mechanical properties to substitute for some bone tissue, but they are generally hydrophobic and have no specific cell recognition sites, which leads to poor cell affinity and adhesion. Some natural polymers, have high cell affinity but are mechanically weak and do not have the strength required as a bone supporting material. In the present study, 3D printed hybrid scaffolds were fab...
Source: Biomed Res - May 25, 2021 Category: Research Authors: Senem Buyuksungur Vasif Hasirci Nesrin Hasirci Source Type: research

Findings of a Cross-Sectional Survey on Knowledge, Attitudes, and Practices about COVID-19 in Uganda: Implications for Public Health Prevention and Control Measures
CONCLUSIONS: This study shows that public health prevention efforts should be directed to closing the identified gaps in KAP among Ugandans in order to halt the spread of COVD-19 in Uganda as well as the East African region.PMID:34031643 | PMC:PMC7729389 | DOI:10.1155/2020/5917378 (Source: Biomed Res)
Source: Biomed Res - May 25, 2021 Category: Research Authors: Gerald Okello Jonathan Izudi Steven Teguzirigwa Allan Kakinda Guido Van Hal Source Type: research

3D printed hybrid bone constructs of PCL and dental pulp stem cells loaded GelMA
J Biomed Mater Res A. 2021 May 25. doi: 10.1002/jbm.a.37235. Online ahead of print.ABSTRACTFabrication of scaffolds using polymers and then cell seeding is a routine protocol of tissue engineering applications. Synthetic polymers have adequate mechanical properties to substitute for some bone tissue, but they are generally hydrophobic and have no specific cell recognition sites, which leads to poor cell affinity and adhesion. Some natural polymers, have high cell affinity but are mechanically weak and do not have the strength required as a bone supporting material. In the present study, 3D printed hybrid scaffolds were fab...
Source: Biomed Res - May 25, 2021 Category: Research Authors: Senem Buyuksungur Vasif Hasirci Nesrin Hasirci Source Type: research

Collagen-based biomaterials for biomedical applications
J Biomed Mater Res B Appl Biomater. 2021 May 24. doi: 10.1002/jbm.b.34881. Online ahead of print.ABSTRACTCollagen is an insoluble fibrous protein that composes the extracellular matrix in animals. Although collagen has been used as a biomaterial since 1881, the properties and the complex structure of collagen are still extensive study subjects worldwide. In this article, several topics of importance for understanding collagen research are reviewed starting from its historical milestones, followed by the description of the collagen superfamily and its complex structures, with a focus on type I collagen. Subsequently, some o...
Source: Biomed Res - May 24, 2021 Category: Research Authors: Erfan Rezvani Ghomi Nooshin Nourbakhsh Mahsa Akbari Kenari Mina Zare Seeram Ramakrishna Source Type: research

Calcium phosphate-based composite cement: Impact of starch type and starch pregelatinization on its physicochemical properties and performance in the vertebral fracture surgical models in vitro
In conclusion, starch pregelatinization and starch botanical source affect the physicochemical properties of CPC significantly. Bone cements modified by different starches also performed differently in surgical models for osteoporotic vertebral fracture. Pregelatinized waxy maize starch may be a better candidate for CPC modification comparing to the pregelatinized normal corn starch.PMID:34028188 | DOI:10.1002/jbm.b.34855 (Source: Biomed Res)
Source: Biomed Res - May 24, 2021 Category: Research Authors: Yixing Tian Huiling Liu Linwei He Rui Zhang Qifeng Lu Chun Liu Ningqi Dang Hui Hu Xuan Ma Dandan Chen Haolin Sun Huan Zhou Lei Yang Yanjie Bai Huilin Yang Source Type: research

Collagen-based biomaterials for biomedical applications
J Biomed Mater Res B Appl Biomater. 2021 May 24. doi: 10.1002/jbm.b.34881. Online ahead of print.ABSTRACTCollagen is an insoluble fibrous protein that composes the extracellular matrix in animals. Although collagen has been used as a biomaterial since 1881, the properties and the complex structure of collagen are still extensive study subjects worldwide. In this article, several topics of importance for understanding collagen research are reviewed starting from its historical milestones, followed by the description of the collagen superfamily and its complex structures, with a focus on type I collagen. Subsequently, some o...
Source: Biomed Res - May 24, 2021 Category: Research Authors: Erfan Rezvani Ghomi Nooshin Nourbakhsh Mahsa Akbari Kenari Mina Zare Seeram Ramakrishna Source Type: research

Calcium phosphate-based composite cement: Impact of starch type and starch pregelatinization on its physicochemical properties and performance in the vertebral fracture surgical models in vitro
In conclusion, starch pregelatinization and starch botanical source affect the physicochemical properties of CPC significantly. Bone cements modified by different starches also performed differently in surgical models for osteoporotic vertebral fracture. Pregelatinized waxy maize starch may be a better candidate for CPC modification comparing to the pregelatinized normal corn starch.PMID:34028188 | DOI:10.1002/jbm.b.34855 (Source: Biomed Res)
Source: Biomed Res - May 24, 2021 Category: Research Authors: Yixing Tian Huiling Liu Linwei He Rui Zhang Qifeng Lu Chun Liu Ningqi Dang Hui Hu Xuan Ma Dandan Chen Haolin Sun Huan Zhou Lei Yang Yanjie Bai Huilin Yang Source Type: research

Prosthetic meshes for hernia repair: State of art, classification, biomaterials, antimicrobial approaches, and fabrication methods
J Biomed Mater Res A. 2021 May 22. doi: 10.1002/jbm.a.37238. Online ahead of print.ABSTRACTWorldwide, hernia repair represents one of the most frequent surgical procedures encompassing a global market valued at several billion dollars. This type of surgery usually requires the implantation of a mesh that needs the appropriate chemical, physical and biological properties for the type of repair. This review thus presents a description of the types of hernias, current hernia repair methods, and the state of the art of prosthetic meshes for hernia repair providing the most important meshes used in clinical practice by surgeons...
Source: Biomed Res - May 22, 2021 Category: Research Authors: Ángel Serrano-Aroca Salvador Pous-Serrano Source Type: research

Prosthetic meshes for hernia repair: State of art, classification, biomaterials, antimicrobial approaches, and fabrication methods
J Biomed Mater Res A. 2021 May 22. doi: 10.1002/jbm.a.37238. Online ahead of print.ABSTRACTWorldwide, hernia repair represents one of the most frequent surgical procedures encompassing a global market valued at several billion dollars. This type of surgery usually requires the implantation of a mesh that needs the appropriate chemical, physical and biological properties for the type of repair. This review thus presents a description of the types of hernias, current hernia repair methods, and the state of the art of prosthetic meshes for hernia repair providing the most important meshes used in clinical practice by surgeons...
Source: Biomed Res - May 22, 2021 Category: Research Authors: Ángel Serrano-Aroca Salvador Pous-Serrano Source Type: research

Regional gene therapy for bone healing using a 3D printed scaffold in a rat femoral defect model
J Biomed Mater Res A. 2021 May 21. doi: 10.1002/jbm.a.37217. Online ahead of print.ABSTRACTAt the present time there are no consistently satisfactory treatment options for some challenging bone loss scenarios. We have previously reported on the properties of a novel 3D-printed hydroxyapatite-composite material in a pilot study, which demonstrated osteoconductive properties but was not tested in a rigorous, clinically relevant model. We therefore utilized a rat critical-sized femoral defect model with a scaffold designed to match the dimensions of the bone defect. The scaffolds were implanted in the bone defect after being ...
Source: Biomed Res - May 21, 2021 Category: Research Authors: H Paco Kang Hansel Ihn Djani M Robertson Xiao Chen Osamu Sugiyama Amy Tang Roger Hollis Tautis Skorka Donald Longjohn Daniel Oakes Ramille Shah Donald Kohn Adam E Jakus Jay R Lieberman Source Type: research

Antimicrobial and self-crosslinking potential of experimentally developed dioctadecyldimethyl ammonium bromide and riboflavin dentin adhesive
J Biomed Mater Res A. 2021 May 21. doi: 10.1002/jbm.a.37221. Online ahead of print.ABSTRACTThe aim of the study is to investigate a new formulation, based on dioctadecyldimethyl ammonium-bromide (QA) and riboflavin (RF), combining antimicrobial activities and protease inhibitory properties with collagen crosslinking without interference to bonding capabilities in a rabbit model. Quaternary ammonium riboflavin (QARF) experimental adhesives modified with dioctadecyldimethyl ammonium-bromide and riboflavin were bonded (0.5/1.0/2.0%) to rabbit dentin to investigate for pulpal-histology, interfacial-morphology, transmission ele...
Source: Biomed Res - May 21, 2021 Category: Research Authors: Umer Daood Ammar Abdullah Malik Muhammad Sharjeel Ilyas Asrar Ahmed Syed Saad B Qasim Spoorthi Ravi Banavar Abdul Samad Khan Esther Kok Sook Kuan Sobia Bilal Jukka Matinlinna Liang Lin Seow Source Type: research

Regional gene therapy for bone healing using a 3D printed scaffold in a rat femoral defect model
J Biomed Mater Res A. 2021 May 21. doi: 10.1002/jbm.a.37217. Online ahead of print.ABSTRACTAt the present time there are no consistently satisfactory treatment options for some challenging bone loss scenarios. We have previously reported on the properties of a novel 3D-printed hydroxyapatite-composite material in a pilot study, which demonstrated osteoconductive properties but was not tested in a rigorous, clinically relevant model. We therefore utilized a rat critical-sized femoral defect model with a scaffold designed to match the dimensions of the bone defect. The scaffolds were implanted in the bone defect after being ...
Source: Biomed Res - May 21, 2021 Category: Research Authors: H Paco Kang Hansel Ihn Djani M Robertson Xiao Chen Osamu Sugiyama Amy Tang Roger Hollis Tautis Skorka Donald Longjohn Daniel Oakes Ramille Shah Donald Kohn Adam E Jakus Jay R Lieberman Source Type: research

Antimicrobial and self-crosslinking potential of experimentally developed dioctadecyldimethyl ammonium bromide and riboflavin dentin adhesive
J Biomed Mater Res A. 2021 May 21. doi: 10.1002/jbm.a.37221. Online ahead of print.ABSTRACTThe aim of the study is to investigate a new formulation, based on dioctadecyldimethyl ammonium-bromide (QA) and riboflavin (RF), combining antimicrobial activities and protease inhibitory properties with collagen crosslinking without interference to bonding capabilities in a rabbit model. Quaternary ammonium riboflavin (QARF) experimental adhesives modified with dioctadecyldimethyl ammonium-bromide and riboflavin were bonded (0.5/1.0/2.0%) to rabbit dentin to investigate for pulpal-histology, interfacial-morphology, transmission ele...
Source: Biomed Res - May 21, 2021 Category: Research Authors: Umer Daood Ammar Abdullah Malik Muhammad Sharjeel Ilyas Asrar Ahmed Syed Saad B Qasim Spoorthi Ravi Banavar Abdul Samad Khan Esther Kok Sook Kuan Sobia Bilal Jukka Matinlinna Liang Lin Seow Source Type: research

Tailoring the growth and proliferation of human dermal fibroblasts by DNA-based polymer films for skin regeneration
This study aimed to evaluate the biocompatibility and interaction of DNA-based polymeric films (DNA-PFs) with primary human fibroblasts (PHF) for regenerative medicine and wound healing purposes. The morphological characterization of the films was performed by scanning electron microscopy, SEM-energy-dispersive X-ray spectroscopy, and atomic force microscopy analysis. Cell viability, cell cycle kinetics, oxidative stress, and migration studies were carried out at 48 and 72 hr of incubation and compared to control cells. Cell adhesion was impaired in the first 24 hr, DNA-PFs with higher concentrations of DNA (1.0 and 2.0 g/...
Source: Biomed Res - May 19, 2021 Category: Research Authors: Cristiano Ceron Jayme Carla Souza Daniela Silvestrini Fernandes Antonio Claudio Tedesco Source Type: research

Electrical therapies act on the Ca < sup > 2+ < /sup > /CaM signaling pathway to enhance bone regeneration with bioactive glass [S53P4] and allogeneic grafts
This study aimed to investigate the application of low-intensity electrostimulation (ES) and electromagnetic stimulation (EM) associated with bioactive glass (BG) or allogeneic grafts (BB) in bone regeneration. A cell viability test on osteoblasts (UMR-106) was performed in the presence of BB and BG grafts associated with ES (10 μA/5 min) and EM (500 Hz/2 min). Critical defects (25 mm2 ) in calvaria were generated in male Wistar rats, and bone regeneration was evaluated on the 30th, 60th, and 120th days after surgery. Cell proliferation increased with the application of ES in both grafts and after EM with BG. Bone remod...
Source: Biomed Res - May 19, 2021 Category: Research Authors: Leonardo Bagne Maraiara A Oliveira Amanda T Pereira Guilherme F Caetano Camila A Oliveira Andr éa A Aro Gabriela B Chiarotto Glaucia M T Santos Fernanda A S Mendon ça Milton Santamaria-Jr Source Type: research

Comparison capacity of collagen hydrogel, mix-powder and in situ hydroxyapatite/collagen hydrogelscaffolds with and without mesenchymal stem cells and platelet-rich plasma in regeneration of critical sized bone defect in a rabbit animal model
J Biomed Mater Res B Appl Biomater. 2021 May 18. doi: 10.1002/jbm.b.34867. Online ahead of print.ABSTRACTThe aim of this study was to investigate the effect of developed collagen (Co) hydrogel (CH), powder-mixed hydroxyapatite/collagen (HA/Co) hydrogel and in situ synthesized HA/Co (In/HA/Co) hydrogel with or without mesenchymal stem cell (MSC) and platelet-rich plasma (PRP) on the regeneration of full-thickness critical size bone defect in the rabbit animal model. In the first step of this study, the scaffolds were synthesized and characterized using FTIR spectroscopy, X-ray diffraction, and scanning electron microcopy. I...
Source: Biomed Res - May 19, 2021 Category: Research Authors: Behnam Bakhtiarimoghadam Sadegh Shirian Esmaeil Mirzaei Siavash Sharifi Iraj Karimi Gelavizh Gharati Sara Takallu Hassan Nazari Source Type: research

Tailoring the growth and proliferation of human dermal fibroblasts by DNA-based polymer films for skin regeneration
This study aimed to evaluate the biocompatibility and interaction of DNA-based polymeric films (DNA-PFs) with primary human fibroblasts (PHF) for regenerative medicine and wound healing purposes. The morphological characterization of the films was performed by scanning electron microscopy, SEM-energy-dispersive X-ray spectroscopy, and atomic force microscopy analysis. Cell viability, cell cycle kinetics, oxidative stress, and migration studies were carried out at 48 and 72 hr of incubation and compared to control cells. Cell adhesion was impaired in the first 24 hr, DNA-PFs with higher concentrations of DNA (1.0 and 2.0 g/...
Source: Biomed Res - May 19, 2021 Category: Research Authors: Cristiano Ceron Jayme Carla Souza Daniela Silvestrini Fernandes Antonio Claudio Tedesco Source Type: research

Electrical therapies act on the Ca < sup > 2+ < /sup > /CaM signaling pathway to enhance bone regeneration with bioactive glass [S53P4] and allogeneic grafts
This study aimed to investigate the application of low-intensity electrostimulation (ES) and electromagnetic stimulation (EM) associated with bioactive glass (BG) or allogeneic grafts (BB) in bone regeneration. A cell viability test on osteoblasts (UMR-106) was performed in the presence of BB and BG grafts associated with ES (10 μA/5 min) and EM (500 Hz/2 min). Critical defects (25 mm2 ) in calvaria were generated in male Wistar rats, and bone regeneration was evaluated on the 30th, 60th, and 120th days after surgery. Cell proliferation increased with the application of ES in both grafts and after EM with BG. Bone remod...
Source: Biomed Res - May 19, 2021 Category: Research Authors: Leonardo Bagne Maraiara A Oliveira Amanda T Pereira Guilherme F Caetano Camila A Oliveira Andr éa A Aro Gabriela B Chiarotto Glaucia M T Santos Fernanda A S Mendon ça Milton Santamaria-Jr Source Type: research

Comparison capacity of collagen hydrogel, mix-powder and in situ hydroxyapatite/collagen hydrogelscaffolds with and without mesenchymal stem cells and platelet-rich plasma in regeneration of critical sized bone defect in a rabbit animal model
J Biomed Mater Res B Appl Biomater. 2021 May 18. doi: 10.1002/jbm.b.34867. Online ahead of print.ABSTRACTThe aim of this study was to investigate the effect of developed collagen (Co) hydrogel (CH), powder-mixed hydroxyapatite/collagen (HA/Co) hydrogel and in situ synthesized HA/Co (In/HA/Co) hydrogel with or without mesenchymal stem cell (MSC) and platelet-rich plasma (PRP) on the regeneration of full-thickness critical size bone defect in the rabbit animal model. In the first step of this study, the scaffolds were synthesized and characterized using FTIR spectroscopy, X-ray diffraction, and scanning electron microcopy. I...
Source: Biomed Res - May 19, 2021 Category: Research Authors: Behnam Bakhtiarimoghadam Sadegh Shirian Esmaeil Mirzaei Siavash Sharifi Iraj Karimi Gelavizh Gharati Sara Takallu Hassan Nazari Source Type: research

Enhancing wound healing dressing development through interdisciplinary collaboration
J Biomed Mater Res B Appl Biomater. 2021 May 17. doi: 10.1002/jbm.b.34861. Online ahead of print.ABSTRACTThe process of wound healing includes four phases: Hemostasis, inflammation, proliferation, and remodeling. Many wound dressings and technologies have been developed to enhance the body's ability to close wounds and restore the function of damaged tissues. Several advancements in wound healing technology have resulted from innovative experiments by individual scientists or physicians working independently. The interplay between the medical and scientific research fields is vital to translating new discoveries in the lab...
Source: Biomed Res - May 18, 2021 Category: Research Authors: Briauna Hawthorne J Kai Simmons Braden Stuart Robert Tung David S Zamierowski Adam J Mellott Source Type: research

Ambient temperature sulfonated carbon fiber reinforced PEEK with hydroxyapatite and reduced graphene oxide hydroxyapatite composite coating
In this study, a combined surface modification technique involving ambient temperature sulfonation and surface coating of (hydroxyapatite (HA), 5%reduced graphene oxide hydroxyapatite(5%RGO/HA) and 10%reduced graphene oxide hydroxyapatite(10%RGO/HA) composites) on 30%CFR-PEEK was achieved with an appropriate temperature treatment at 345°C in nitrogen. The coatings adhered unto the surface of S30%CFR-PEEK with an improved hydrophilicity and bioactivity. With the sample S30%CFR-PEEK+HA, having the highest enhanced hydrophilicity from 112.5 ± 2.5° to 20 ± 2° and bioactivity. An improvement in hydroph...
Source: Biomed Res - May 18, 2021 Category: Research Authors: Naomi Addai Asante Youfa Wang Shahd Bakhet Shefiu Kareem Kwadwo Asare Owusu Yuandi Hu Millicent Appiah Source Type: research

Enhancing wound healing dressing development through interdisciplinary collaboration
J Biomed Mater Res B Appl Biomater. 2021 May 17. doi: 10.1002/jbm.b.34861. Online ahead of print.ABSTRACTThe process of wound healing includes four phases: Hemostasis, inflammation, proliferation, and remodeling. Many wound dressings and technologies have been developed to enhance the body's ability to close wounds and restore the function of damaged tissues. Several advancements in wound healing technology have resulted from innovative experiments by individual scientists or physicians working independently. The interplay between the medical and scientific research fields is vital to translating new discoveries in the lab...
Source: Biomed Res - May 18, 2021 Category: Research Authors: Briauna Hawthorne J Kai Simmons Braden Stuart Robert Tung David S Zamierowski Adam J Mellott Source Type: research

Ambient temperature sulfonated carbon fiber reinforced PEEK with hydroxyapatite and reduced graphene oxide hydroxyapatite composite coating
In this study, a combined surface modification technique involving ambient temperature sulfonation and surface coating of (hydroxyapatite (HA), 5%reduced graphene oxide hydroxyapatite(5%RGO/HA) and 10%reduced graphene oxide hydroxyapatite(10%RGO/HA) composites) on 30%CFR-PEEK was achieved with an appropriate temperature treatment at 345°C in nitrogen. The coatings adhered unto the surface of S30%CFR-PEEK with an improved hydrophilicity and bioactivity. With the sample S30%CFR-PEEK+HA, having the highest enhanced hydrophilicity from 112.5 ± 2.5° to 20 ± 2° and bioactivity. An improvement in hydroph...
Source: Biomed Res - May 18, 2021 Category: Research Authors: Naomi Addai Asante Youfa Wang Shahd Bakhet Shefiu Kareem Kwadwo Asare Owusu Yuandi Hu Millicent Appiah Source Type: research

Experimental Study on the Correlation between miRNA-373 and HIF-1 < em > α < /em > , MMP-9, and VEGF in the Development of HIE
CONCLUSION: The increased change in miRNA-373 expression has a certain diagnostic significance on neonatal HIE. In the occurrence and development of HIE, miRNA-373 is positively correlated with HIF-1α, MMP-9, and VEGF.PMID:33997006 | PMC:PMC8112928 | DOI:10.1155/2021/5553486 (Source: Biomed Res)
Source: Biomed Res - May 17, 2021 Category: Research Authors: Chun-Yang Liu Hisham Al-Ward Francine Ngaffo Mekontso Ning Liu Hui-Qin Zeng Min Liu Zi-Rui Yu Lin Zhang Yu-Chun Han Hui Xu Source Type: research

Urinary Angiogenin as a Marker for Bladder Cancer: A Meta-Analysis
CONCLUSION: This meta-analysis showed that ANG could be a fair biomarker for the diagnosis of BCa patients.PMID:33997007 | PMC:PMC8099530 | DOI:10.1155/2021/5557309 (Source: Biomed Res)
Source: Biomed Res - May 17, 2021 Category: Research Authors: Amir Hossein Aalami Hossein Abdeahad Mohammad Mesgari Thozhukat Sathyapalan Amirhossein Sahebkar Source Type: research

Chemical Composition, Antibacterial, and Anti-Inflammatory Activities of Essential Oils from Flower, Leaf, and Stem of < em > Rhynchanthus beesianus < /em >
In this study, the chemical constituents, antibacterial, and anti-inflammatory properties of flower essential oil (F-EO), leaf essential oil (L-EO), and stem essential oil (S-EO) of R. beesianus were investigated for the first time. According to the GC-FID/MS assay, the F-EO was mainly composed of bornyl formate (21.7%), 1,8-cineole (21.6%), borneol (9.7%), methyleugenol (7.7%), β-myrcene (5.4%), limonene (4.7%), camphene (4.5%), linalool (3.4%), and α-pinene (3.1%). The predominant components of L-EO were bornyl formate (33.9%), borneol (13.2%), 1,8-cineole (12.1%), methyleugenol (8.0%), camphene (7.8%), bornyl...
Source: Biomed Res - May 17, 2021 Category: Research Authors: Qi Chen Xiaoge Zhao Tingya Lu Yao Yang Yi Hong Minyi Tian Ying Zhou Source Type: research

Status of Bioinformatics Education in South Asia: Past and Present
This article renders bioinformatics, measures, and its importance of implementation in South Asia with proper ways of improving bioinformatics education flaws. It also addresses the problems faced in South Asia and proposes some recommendations regarding bioinformatics education. The information regarding bioinformatics education and institutes was collected from different existing research papers, databases, and surveys. The information was then confirmed by visiting each institution's website, while problems and solutions displayed in the article are mostly in line with South Asian bioinformatics conferences and institut...
Source: Biomed Res - May 17, 2021 Category: Research Authors: Muhammad Muddassir Ali Muhammad Hamid Muhammad Saleem Saadia Malik Natash Ali Mian Muhammad Ahmed Ihsan Nadia Tabassum Khalid Mehmood Furqan Awan Source Type: research

Irisin Has a Protective Role against Osteoporosis in Ovariectomized Rats
This study was planned to examine irisin's impact in preventing osteoporosis after ovariectomy. 4 groups of female albino rats (10 rats/group): control, sham-operated, ovariectomized (OVX-control), and OVX-irisin-treated. Serum levels of bone markers [osteocalcin (OC), bone alkaline phosphatase (BALP), tartrate-resistant acid phosphatase (TRAP), calcium (Ca++), phosphorus (P)], glucose, and insulin were being measured. Body mass index, Homeostatic Model Assessment of Insulin Resistance (HOMA-IR), dry and ash femur weight, and bone contents of Ca++ and P were investigated. The femur was examined histopathologically. The OVX...
Source: Biomed Res - May 17, 2021 Category: Research Authors: Enas N Morgan Ashwag Saleh Alsharidah Ayman M Mousa Husam M Edrees Source Type: research

Interaction of Adiponectin Genotypes and Insulin Resistance on the Occurrence of Taiwanese Metabolic Syndrome
CONCLUSION: Our data suggested that apM1 +45 genotypes might modify the effect of insulin resistance on the development of Taiwanese MetS.PMID:33997011 | PMC:PMC8110375 | DOI:10.1155/2021/5570827 (Source: Biomed Res)
Source: Biomed Res - May 17, 2021 Category: Research Authors: Chun-Chieh Chen Yu-Hsiang Wei Chia-Chen Huang Shin-Hui Hung Zeng-Wei Wang Ruey-Hong Wong Source Type: research

Correlation between Chest X-Ray Severity in COVID-19 and Age in Mexican-Mestizo Patients: An Observational Cross-Sectional Study
Biomed Res Int. 2021 Apr 29;2021:5571144. doi: 10.1155/2021/5571144. eCollection 2021.ABSTRACTINTRODUCTION: Chest X-ray (CXR) is used for the initial triage of patients with suspected COVID-19. Studies of CXR scoring in the European population found a higher score in males than in females and significantly correlated with age. Because there have not been studies in the Mexican-mestizo community, we aimed to compare the differences in CXR scores between males and females and their correlation with age after controlling comorbidities like diabetes and hypertension.MATERIALS AND METHODS: A retrospective study of 1000 CXR of M...
Source: Biomed Res - May 17, 2021 Category: Research Authors: Arturo Albrandt-Salmeron Ruby Espejo-Fonseca Ernesto Roldan-Valadez Source Type: research

Investigating the Possibility of Green Synthesis of Silver Nanoparticles Using < em > Vaccinium arctostaphlyos < /em > Extract and Evaluating Its Antibacterial Properties
CONCLUSION: The synthesized nanoparticles showed more antibacterial properties against gram-positive bacteria (Bacillus subtilis and Staphylococcus aureus) than gram-negative ones (Escherichia coli and Salmonella enteritidis).PMID:33997013 | PMC:PMC8110411 | DOI:10.1155/2021/5572252 (Source: Biomed Res)
Source: Biomed Res - May 17, 2021 Category: Research Authors: Sedighe Khodadadi Nafiseh Mahdinezhad Bahman Fazeli-Nasab Mohammad Javad Heidari Baratali Fakheri Abdolhossein Miri Source Type: research

The Effect of Preoperative Biliary Drainage with or without Pancreatic Stenting on Complications after Pancreatoduodenectomy: A Retrospective Cohort Study
CONCLUSION: Our data suggested that PBD and pancreatic duct stenting prior to pancreatoduodenectomy would increase the risk of postoperative delayed gastric emptying, while the overall incidence of postoperative complications and other complications, such as pancreatic leakage and bile duct leakage, showed no statistical difference.PMID:33997014 | PMC:PMC8105100 | DOI:10.1155/2021/5572395 (Source: Biomed Res)
Source: Biomed Res - May 17, 2021 Category: Research Authors: Jiangtao Chu Shun He Yan Ke Xudong Liu Peng Wang Wei Zhang Guotong Qiu Chengfeng Wang Jianwei Zhang Guiqi Wang Source Type: research

Association between Low Muscle Mass and Inflammatory Cytokines
This study involved 299 participants (127 men and 172 women; mean age 63.3 ± 9.8 years) who underwent health checkups for body composition and inflammatory cytokine (TNF-alpha, IL-6, and MCP-1) levels. Muscle mass was determined using the skeletal muscle mass index. We divided the participants into the normal (N) and low muscle mass (L) groups and compared the levels of inflammatory cytokines in nonelderly (
Source: Biomed Res - May 17, 2021 Category: Research Authors: Sadayuki Ito Hiroaki Nakashima Kei Ando Kazuyoshi Kobayashi Masaaki Machino Taisuke Seki Shinya Ishizuka Ryosuke Fujii Yasuhiko Takegami Hiroya Yamada Yoshitaka Ando Koji Suzuki Yukiharu Hasegawa Shiro Imagama Source Type: research

Expression and Clinical Significance of miR-146a and Tumor Necrosis Factor Receptor-Associated Factor 6 (TRAF6) in Myasthenia Gravis Patient Serum
CONCLUSION: miR-146a and TRAF6 mRNA are highly expressed in MG patients and can affect MG occurrence. miR-146a is a suitable candidate marker for diagnosing MG.PMID:33997016 | PMC:PMC8081603 | DOI:10.1155/2021/5573469 (Source: Biomed Res)
Source: Biomed Res - May 17, 2021 Category: Research Authors: Mei Yan Yue Fu Hui Rao Huiling Zhou Xiaohuang Liang Source Type: research

Diagnosis of Cervical Cancer based on Ensemble Deep Learning Network using Colposcopy Images
Biomed Res Int. 2021 May 4;2021:5584004. doi: 10.1155/2021/5584004. eCollection 2021.ABSTRACTTraditional screening of cervical cancer type classification majorly depends on the pathologist's experience, which also has less accuracy. Colposcopy is a critical component of cervical cancer prevention. In conjunction with precancer screening and treatment, colposcopy has played an essential role in lowering the incidence and mortality from cervical cancer over the last 50 years. However, due to the increase in workload, vision screening causes misdiagnosis and low diagnostic efficiency. Medical image processing using the convol...
Source: Biomed Res - May 17, 2021 Category: Research Authors: Venkatesan Chandran M G Sumithra Alagar Karthick Tony George M Deivakani Balan Elakkiya Umashankar Subramaniam S Manoharan Source Type: research

Identification of Hearing Loss-Associated Variants of < em > PTPRQ < /em > , < em > MYO15A < /em > , and < em > SERPINB6 < /em > in Pakistani Families
This study reports the identification of novel disease-causing variants in three known deafness genes and further highlights the genetic heterogeneity of HL in Pakistani population.PMID:33997018 | PMC:PMC8080868 | DOI:10.1155/2021/5584788 (Source: Biomed Res)
Source: Biomed Res - May 17, 2021 Category: Research Authors: Umair Mahmood Shazia A Bukhari Muhammad Ali Zubair M Ahmed Saima Riazuddin Source Type: research

Therapeutic Efficacy of Aerobic Exercise Training along with Oak Husk Hydroalcoholic Extract for Amelioration of Inflammation in Obese Elderly Male Mice
Biomed Res Int. 2021 May 3;2021:5585077. doi: 10.1155/2021/5585077. eCollection 2021.ABSTRACTBACKGROUND: Fibrinogen and interleukin-1β as a proinflammatory cytokine and interleukin-10 and nesfatin-1 as an anti-inflammatory cytokine have an important role in the development and prevention of systemic inflammation and incidence of obesity-induced diseases. Thus, this study is aimed at the interaction effects of aerobic training and oak husk hydroalcoholic extract consumption on plasma levels of fibrinogen, interleukin-1β, nesfatin-1, and interleukin-10 in obese elderly male mice.MATERIALS AND METHODS: In this exper...
Source: Biomed Res - May 17, 2021 Category: Research Authors: Iman Zakavi Shila Nayebifar Elham Ghasemi Aliasghar Valipour Source Type: research

Antilingula as a Surgical Reference Point for Vertical Ramus Osteotomy
CONCLUSION: Antilingula-related distances did not differ between skeletal patterns. Among antilingula-related variables, A-AntiL could serve as a favorable measuring point during operation.PMID:33997020 | PMC:PMC8081601 | DOI:10.1155/2021/5585297 (Source: Biomed Res)
Source: Biomed Res - May 17, 2021 Category: Research Authors: Han-Sheng Chen Ying-Sheng Chen I-Ling Lin Chun-Feng Chen Source Type: research

Importance in the Occurrence Distribution of Minimum Oropharyngeal Cross-Sectional Area in the Different Skeletal Patterns Using Cone-Beam Computed Tomography
CONCLUSION: Patients in skeletal Class II had significantly smaller oropharyngeal airway areas and volumes than those in Class III did. The minimum oropharyngeal cross-sectional area had a 67% probability of occurrence in the upper oropharyngeal airway among patients in Class I and Class II and a 50% probability of occurrence among patients in Class III.PMID:33997021 | PMC:PMC8116163 | DOI:10.1155/2021/5585629 (Source: Biomed Res)
Source: Biomed Res - May 17, 2021 Category: Research Authors: Ying-Sheng Chen Szu-Ting Chou Jung-Hsuan Cheng Shis-Chieh Chen Chin-Yun Pan Yu-Chuan Tseng Source Type: research

Increase in Free Hepatic Venous Pressure Response to Beta-Blockers Predicts Variceal Bleeding in Cirrhotic Patients
CONCLUSION: Increase ≥ 1.75 mmHg in FHVP responding to beta-blockers in cirrhotic patients with GOV indicates high risk of variceal bleeding. Besides HVPG response, change of FHVP should also be valued in hemodynamic evaluation to beta-blockers. This trial is registered with Chinese Clinical Trial Registry ChiCTR-IPR-17012836.PMID:33997022 | PMC:PMC8096544 | DOI:10.1155/2021/5587566 (Source: Biomed Res)
Source: Biomed Res - May 17, 2021 Category: Research Authors: Huiwen Guo Jiangqiang Xiao Yi Wang Ming Zhang Yuzheng Zhuge Feng Zhang Source Type: research

Impact of Bleaching before or after Veneer Preparation on Color Masking Ability of Laminate Veneers: An In Vitro Study
This study evaluates the effect of bleaching before or after veneer preparation and the depth of preparation on color masking ability of laminate veneers. Methods. Sixty extracted premolars were artificially stained to vita shade A4, verified by digital spectrophotometer (Vita Easy Shade V), and then divided into three groups: NB = nonbleached, BBP = bleaching before preparation, and BAP = bleaching after preparation. Based on the preparation depths, each group was further divided into two subgroups: S1 = 0.5 mm and S2 = 1.0 mm. BBP and BAP were subjected to one session of in-office bleaching using 35% hydrogen peroxide. I...
Source: Biomed Res - May 17, 2021 Category: Research Authors: Gollshang Ahmad Mhammed Dalloo Bestoon Mohammed Faraj Abdulsalam Rasheed Al-Zahawi Source Type: research

A Retrospective Study of Unicompartmental Knee Arthroplasty Functional Outcome and the Incidence of Medial Meniscus Posterior Root Tear in Spontaneous Osteonecrosis of the Knee
CONCLUSION: Unicompartmental arthroplasty for SONK is less destructive to the native knee structure than total knee arthroplasty but can achieve comparable prognosis with strict patient selection. While the precise etiology of SONK is unknown, one theory posits that a MMPRT may change the biomechanical circumstances of the knee joint, leading to osteonecrosis. Although not confirmatory, the high prevalence rate suggests that MMPRT may have a key role in the development of SONK. UKA is an effective treatment option for SONK, resulting in significant functional improvement. Long-term (>10 years) outcomes should be investi...
Source: Biomed Res - May 17, 2021 Category: Research Authors: Po-Ju Wu Tsung Yu Lin Yung Chang Lu Source Type: research

Prevalence and Antimicrobial Susceptibility of < em > Streptococcus pneumoniae < /em > Isolated from Clinical Samples in the Past 8 Years in Korea
Biomed Res Int. 2021 Apr 28;2021:6615334. doi: 10.1155/2021/6615334. eCollection 2021.ABSTRACTPneumococcal infection is the main causative agent of pneumonia, meningitis, and sepsis in immunocompromised and elderly people. The samples in this study were collected from subjects in an 800-bed hospital in Chungnam province, Korea, over the past 8 years. Of the 473,230 samples obtained for microbial culture from 2012 to 2019, Streptococcus pneumoniae was isolated from 714 samples collected from 702 patients, with a pneumococcal-positive rate of 0.15%. We investigated the temporal, demographic, and specimen-specific distributio...
Source: Biomed Res - May 17, 2021 Category: Research Authors: Jae Soo Kim Bo Kyeung Jung Jong Wan Kim Ga Yeon Kim Source Type: research

Development of Perphenazine-Loaded Solid Lipid Nanoparticles: Statistical Optimization and Cytotoxicity Studies
CONCLUSION: Our study suggests that PPZ-SLNs can make a promising vehicle for a suitable therapy of schizophrenia for the oral drug delivery system.PMID:33997026 | PMC:PMC8099510 | DOI:10.1155/2021/6619195 (Source: Biomed Res)
Source: Biomed Res - May 17, 2021 Category: Research Authors: Parisa Abbasi Farsani Reza Mahjub Mojdeh Mohammadi Seyed Sajad Oliaei Mohammad Mehdi Mahboobian Source Type: research