Immune Checkpoint Inhibitor Myotoxicities: An Autoimmune Perspective
Intern Med. 2024 Apr 23. doi: 10.2169/internalmedicine.3700-24. Online ahead of print.NO ABSTRACTPMID:38658335 | DOI:10.2169/internalmedicine.3700-24 (Source: Internal Medicine)
Source: Internal Medicine - April 24, 2024 Category: Internal Medicine Authors: Kazuko Tajiri Source Type: research
Primary Extranodal Diffuse Large B-cell Lymphoma Presenting in the Lips: A Case Report and Literature Review
Intern Med. 2024 Apr 23. doi: 10.2169/internalmedicine.3675-24. Online ahead of print.ABSTRACTApproximately 30-40% of malignant lymphomas are classified as diffuse large B-cell lymphoma (DLBCL), with 30% of DLBCL cases manifesting as extranodal lymphomas. Among these extranodal DLBCLs, primary DLBCL in oral lesions, particularly in the lips, is rare. While the treatment methods, chemotherapy assessment, and prognosis for nodal and extranodal DLBCLs are generally similar, diagnostic challenges can lead to delayed therapeutic intervention. We herein present a recent case of primary extranodal DLBCL in the lips that was swift...
Source: Internal Medicine - April 24, 2024 Category: Internal Medicine Authors: Hideshige Seki Ken Morita Megumi Yasunaga Masanori Toho Hiroaki Maki Mineo Kurokawa Source Type: research
Fatal systemic capillary leak syndrome in a patient with a COVID-19 infection
Intern Med. 2024 Apr 23. doi: 10.2169/internalmedicine.3637-24. Online ahead of print.ABSTRACTA 29-year-old Japanese woman was admitted to our hospital with a fever, cardiogenic shock, and cardiac arrest. Laboratory data indicated multiple organ failure in addition to hemoconcentration, hypoalbuminemia, and myocardial damage. The coronary angiography findings were normal, and fulminant myocarditis was suspected. Venoarterial peripheral extracorporeal membrane oxygenation and an Impella CP left ventricular assist device were initiated, along with the administration of positive inotropic agents. However, hypovolemic shock an...
Source: Internal Medicine - April 24, 2024 Category: Internal Medicine Authors: Hiroaki Kawano Masataka Umeda Tomohiro Honda Ryosuke Iwasaki Shinji Okano Ryohei Akashi Tomohiro Koga Koichi Izumikawa Atsushi Kawakami Koji Maemura Source Type: research
Cases: Decompensated Heart Failure Secondary to Hypopituitarism in an Elderly Patient
Intern Med. 2024 Apr 23. doi: 10.2169/internalmedicine.3491-24. Online ahead of print.ABSTRACTHypopituitarism is difficult to diagnose because of its non-specific symptoms, especially in the presence of comorbidities. A 77-year-old woman with worsening anorexia and exertional dyspnea was initially diagnosed with decompensated dry cold-type heart failure. Hormonal laboratory tests indicated secondary hypothyroidism as a part of the evaluation of heart failure. Furthermore, pituitary magnetic resonance imaging revealed thickening of the pituitary stalk and a loss of signal intensity in the posterior pituitary, thus suggestin...
Source: Internal Medicine - April 24, 2024 Category: Internal Medicine Authors: Yumiko Yoshino Yoshihiro Harano Toshiro Shibata Junko Shiroko Source Type: research
Early gastric cancer accompanying Gastritis cystica profunda with a Giant cyst
Intern Med. 2024 Apr 23. doi: 10.2169/internalmedicine.3460-24. Online ahead of print.NO ABSTRACTPMID:38658339 | DOI:10.2169/internalmedicine.3460-24 (Source: Internal Medicine)
Source: Internal Medicine - April 24, 2024 Category: Internal Medicine Authors: Hironao Matsumoto Takeshi Yamashina Masaaki Shimatani Source Type: research
Treatment of cryptogenic new-onset refractory status epilepticus (C-NORSE) with tocilizumab: A case report
Intern Med. 2024 Apr 23. doi: 10.2169/internalmedicine.3392-23. Online ahead of print.ABSTRACTA 35-year-old woman with no prior history of epilepsy developed status epilepticus (SE), which was highly resistant to multiple antiseizure medications and sedatives. The etiology of SE was not identified despite extensive investigation, and the patient was diagnosed with cryptogenic new-onset refractory status epilepticus (C-NORSE). Although first-line immunotherapies such as high-dose corticosteroids and plasma exchange were ineffective, the patient manifested a resolution of SE after the administration of tocilizumab, which inh...
Source: Internal Medicine - April 24, 2024 Category: Internal Medicine Authors: Yumiko Nakamura Masayuki Ueda Satoshi Kodama Tomohiko Kimura Yuichiro Shirota Masashi Hamada Hiroyuki Ishiura Takahiro Iizuka Tatsushi Toda Source Type: research
Successful treatment for life threatening recurrent non-traumatic rectus sheath hematoma in a case with microscopic polyangiitis with rapidly progressive glomerulonephritis
Intern Med. 2024 Apr 23. doi: 10.2169/internalmedicine.3239-23. Online ahead of print.ABSTRACTA 68-year-old woman was admitted to our hospital because of a rapid progression of renal dysfunction with positive myeloperoxidase antineutrophil cytoplasmic antibody and was diagnosed with rapidly progressive glomerulonephritis associated with microscopic polyangiitis (MPA). Severe right rectus sheath hematoma (RSH) bleeding from the inferior epigastric artery developed after starting hemodialysis, which required 4 transarterial embolizations due to recurrent bleeding. After additional treatment with methylprednisolone pulse ther...
Source: Internal Medicine - April 24, 2024 Category: Internal Medicine Authors: Hiroyuki Nakanoh Hidemi Takeuchi Morimoto Shiho Yuya Terajima Shugo Okamoto Yasuhiro Onishi Keiko Tanaka Takayuki Katsuyama Kenji Tsuji Yoshinori Matsumoto Katsuyuki Tanabe Hiroshi Morinaga Mayu Uka Koji Tomita Haruhito A Uchida Takao Hiraki Jun Wada Source Type: research
Association between sleep duration and a new onset of nonalcoholic fatty liver disease
Conclusions In women, a short sleep duration was independently associated with the onset of NAFLD, thus suggesting that an adequate sleep duration can be a promising preventive factor for the onset of NAFLD in women.PMID:38658342 | DOI:10.2169/internalmedicine.3119-23 (Source: Internal Medicine)
Source: Internal Medicine - April 24, 2024 Category: Internal Medicine Authors: Hiromichi Imaizumi Atsushi Takahashi Yosuke Takahata Yukio Anzai Atsuko Kogre Chiharu Sakuma Naoto Abe Tatsuro Sugaya Masashi Fujita Manabu Hayashi Kazumichi Abe Hiromasa Ohira Source Type: research
A Rare Case of Overlapping Durvalumab-induced Myositis, Takotsubo-like Morphological Changes Caused by Myocarditis, and Myasthenia Gravis
Intern Med. 2024 Apr 23. doi: 10.2169/internalmedicine.3028-23. Online ahead of print.ABSTRACTImmune checkpoint inhibitors can cause a range of immune-related adverse events, including myositis, Takotsubo cardiomyopathy, and myasthenia gravis. We herein report a rare case of a 78-year-old man with concurrent durvalumab-induced myositis, Takotsubo-like morphological changes caused by myocarditis, and myasthenia gravis. The patient initially required invasive ventilation and exhibited symptoms of myasthenia gravis after treatment with high-dose steroids. However, he subsequently achieved successful recovery after the adminis...
Source: Internal Medicine - April 24, 2024 Category: Internal Medicine Authors: Shoichiro Saito Shigeto Hontsu Junya Hiraoka Ai Yamanaka Nobuhiro Fujioka Daisuke Shimada Yosuke Okuda Kazuma Sugie Shigeo Muro Source Type: research
Immune Checkpoint Inhibitor Myotoxicities: An Autoimmune Perspective
Intern Med. 2024 Apr 23. doi: 10.2169/internalmedicine.3700-24. Online ahead of print.NO ABSTRACTPMID:38658335 | DOI:10.2169/internalmedicine.3700-24 (Source: Internal Medicine)
Source: Internal Medicine - April 24, 2024 Category: Internal Medicine Authors: Kazuko Tajiri Source Type: research
Primary Extranodal Diffuse Large B-cell Lymphoma Presenting in the Lips: A Case Report and Literature Review
Intern Med. 2024 Apr 23. doi: 10.2169/internalmedicine.3675-24. Online ahead of print.ABSTRACTApproximately 30-40% of malignant lymphomas are classified as diffuse large B-cell lymphoma (DLBCL), with 30% of DLBCL cases manifesting as extranodal lymphomas. Among these extranodal DLBCLs, primary DLBCL in oral lesions, particularly in the lips, is rare. While the treatment methods, chemotherapy assessment, and prognosis for nodal and extranodal DLBCLs are generally similar, diagnostic challenges can lead to delayed therapeutic intervention. We herein present a recent case of primary extranodal DLBCL in the lips that was swift...
Source: Internal Medicine - April 24, 2024 Category: Internal Medicine Authors: Hideshige Seki Ken Morita Megumi Yasunaga Masanori Toho Hiroaki Maki Mineo Kurokawa Source Type: research
Fatal systemic capillary leak syndrome in a patient with a COVID-19 infection
Intern Med. 2024 Apr 23. doi: 10.2169/internalmedicine.3637-24. Online ahead of print.ABSTRACTA 29-year-old Japanese woman was admitted to our hospital with a fever, cardiogenic shock, and cardiac arrest. Laboratory data indicated multiple organ failure in addition to hemoconcentration, hypoalbuminemia, and myocardial damage. The coronary angiography findings were normal, and fulminant myocarditis was suspected. Venoarterial peripheral extracorporeal membrane oxygenation and an Impella CP left ventricular assist device were initiated, along with the administration of positive inotropic agents. However, hypovolemic shock an...
Source: Internal Medicine - April 24, 2024 Category: Internal Medicine Authors: Hiroaki Kawano Masataka Umeda Tomohiro Honda Ryosuke Iwasaki Shinji Okano Ryohei Akashi Tomohiro Koga Koichi Izumikawa Atsushi Kawakami Koji Maemura Source Type: research
Cases: Decompensated Heart Failure Secondary to Hypopituitarism in an Elderly Patient
Intern Med. 2024 Apr 23. doi: 10.2169/internalmedicine.3491-24. Online ahead of print.ABSTRACTHypopituitarism is difficult to diagnose because of its non-specific symptoms, especially in the presence of comorbidities. A 77-year-old woman with worsening anorexia and exertional dyspnea was initially diagnosed with decompensated dry cold-type heart failure. Hormonal laboratory tests indicated secondary hypothyroidism as a part of the evaluation of heart failure. Furthermore, pituitary magnetic resonance imaging revealed thickening of the pituitary stalk and a loss of signal intensity in the posterior pituitary, thus suggestin...
Source: Internal Medicine - April 24, 2024 Category: Internal Medicine Authors: Yumiko Yoshino Yoshihiro Harano Toshiro Shibata Junko Shiroko Source Type: research
Early gastric cancer accompanying Gastritis cystica profunda with a Giant cyst
Intern Med. 2024 Apr 23. doi: 10.2169/internalmedicine.3460-24. Online ahead of print.NO ABSTRACTPMID:38658339 | DOI:10.2169/internalmedicine.3460-24 (Source: Internal Medicine)
Source: Internal Medicine - April 24, 2024 Category: Internal Medicine Authors: Hironao Matsumoto Takeshi Yamashina Masaaki Shimatani Source Type: research
Treatment of cryptogenic new-onset refractory status epilepticus (C-NORSE) with tocilizumab: A case report
Intern Med. 2024 Apr 23. doi: 10.2169/internalmedicine.3392-23. Online ahead of print.ABSTRACTA 35-year-old woman with no prior history of epilepsy developed status epilepticus (SE), which was highly resistant to multiple antiseizure medications and sedatives. The etiology of SE was not identified despite extensive investigation, and the patient was diagnosed with cryptogenic new-onset refractory status epilepticus (C-NORSE). Although first-line immunotherapies such as high-dose corticosteroids and plasma exchange were ineffective, the patient manifested a resolution of SE after the administration of tocilizumab, which inh...
Source: Internal Medicine - April 24, 2024 Category: Internal Medicine Authors: Yumiko Nakamura Masayuki Ueda Satoshi Kodama Tomohiko Kimura Yuichiro Shirota Masashi Hamada Hiroyuki Ishiura Takahiro Iizuka Tatsushi Toda Source Type: research
