Symptomatic Sinus Bradycardia in a Patient with Solitary Fibrous Tumor/Hemangiopericytoma Treated with Pazopanib
Intern Med. 2021 Apr 5. doi: 10.2169/internalmedicine.5347-20. Online ahead of print.ABSTRACTPazopanib, a multi-targeted tyrosine kinase inhibitor, is associated with cardiovascular adverse events, such as hypertension, cardiac dysfunction, and thromboembolism. However, symptomatic pazopanib-related bradycardia is uncommon. We herein report a case of symptomatic bradycardia of 35 beats per minute in a patient with solitary fibrous tumor/hemangiopericytoma (SFT/HPC) treated with pazopanib for 1 month. His heart rate recovered to a normal range soon after pazopanib cessation. He restarted pazopanib at a reduced dose, which w...
Source: Internal Medicine - April 5, 2021 Category: Internal Medicine Authors: Wataru Shioyama Toru Oka Risa Kamada Toshinari Yagi Katsuhiko Nakanishi Tatsuya Nishikawa Taku Yasui Masashi Fujita Source Type: research

Clinico-radiologic Characteristics of Pulmonary Visceral Larva Migrans Caused by Ascaris suum
Conclusion Consumption of raw organic vegetables or raw meat is a possible route of A. suum infection. Infected patients exhibit mild respiratory symptoms, and multiple nodules with a halo in the subpleural area are a common finding on chest HRCT. Treatment with albendazole was effective in these cases.PMID:33814489 | DOI:10.2169/internalmedicine.6109-20 (Source: Internal Medicine)
Source: Internal Medicine - April 5, 2021 Category: Internal Medicine Authors: Nobuhiro Matsumoto Hironobu Tsubouchi Kensuke Setoguchi Takanori Horiguchi Takafumi Shigekusa Shinpei Tsuchida Ayako Matsuo Yasuharu Oda Shigehisa Yanagi Haruhiko Maruyama Masamitsu Nakazato Source Type: research

A Case of Birt-Hogg-Dub é Syndrome with Renal Cancer Treated as Multiple Metastases of Cancer of Unknown Primary
Intern Med. 2021 Apr 5. doi: 10.2169/internalmedicine.6309-20. Online ahead of print.ABSTRACTA 60-year-old woman presented with multiple lung and bone metastases with unknown primary cancer. Chest CT images showed multiple pulmonary cysts, predominantly of the middle and lower lobes. She also had a history of pneumothorax. Four years after chemotherapy and radiation therapy, multiple hypervascular tumors eventually developed in the bilateral kidneys, suggesting the possibility of Birt-Hogg-Dube (BHD) syndrome. Genetic testing revealed a folliculin mutation, which confirmed the diagnosis of BHD syndrome. When we encounter c...
Source: Internal Medicine - April 5, 2021 Category: Internal Medicine Authors: Natsuko Atsukawa Toshinari Yagi Chiaki Kubo Katsuyuki Nakanishi Keigo Osuga Source Type: research

Self-remitting Elevation of Adenosine Deaminase Levels in the Cerebrospinal Fluid with Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy: A Case Report and Review of the Literature
Intern Med. 2021 Apr 5. doi: 10.2169/internalmedicine.6457-20. Online ahead of print.ABSTRACTA 29-year-old man presented with a high-grade fever, headache, and urinary retention, in addition to meningeal irritation and myoclonus in his upper extremities. A cerebrospinal fluid (CSF) examination showed pleocytosis and high adenosine deaminase (ADA) levels with no evidence of bacterial infection, including Mycobacterium tuberculosis. T2-weighted brain magnetic resonance imaging showed transient hyper-intensity lesions at the splenium of the corpus callosum (SCC), bilateral putamen, and pons during the course of the disease. T...
Source: Internal Medicine - April 5, 2021 Category: Internal Medicine Authors: Sota Nakamura Teppei Fujioka Shoji Kawashima Takatsune Kawaguchi Masayuki Mizuno Masahiro Omura Kenji Okita Akio Kimura Takayoshi Shimohata Noriyuki Matsukawa Source Type: research

Successful Re-administration of Atezolizumab for a Non-small-cell Lung Cancer Patient after Cardiac Tamponade Development as a Manifestation of Pseudo-progression Induced by Combination Treatment with Atezolizumab and Cytotoxic Chemotherapy
Intern Med. 2021 Apr 5. doi: 10.2169/internalmedicine.6509-20. Online ahead of print.ABSTRACTPseudo-progression is a phenomenon induced by treatment with immune checkpoint inhibitors and is characterized by an increase in tumor size or the appearance of new lesions, followed by tumor regression. However, life-threatening conditions, such as cardiac tamponade, can develop in such patients. We herein report on a 69-year-old man with lung adenocarcinoma who developed cardiac tamponade as a manifestation of pseudo-progression induced by treatment with atezolizumab combined with cytotoxic chemotherapy. After managing the cardia...
Source: Internal Medicine - April 5, 2021 Category: Internal Medicine Authors: Koki Nakashima Yoshiki Demura Masayuki Sato Yuya Fujii Kazunari Igarashi Tamotsu Ishizuka Source Type: research

Cryptococcosis in the Vocal Cords, Trachea, and Bronchi
Intern Med. 2021 Apr 5. doi: 10.2169/internalmedicine.6559-20. Online ahead of print.ABSTRACTLaryngeal and endobronchial cryptococcosis are rare conditions, and to our knowledge, there have been only 23 cases of laryngeal cryptococcosis, and 18 cases of endobronchial cryptococcosis previously reported in the English literature. We herein report an extremely rare case of cryptococcosis with simultaneous laryngeal and endobronchial involvement. This case highlights the importance of paying close attention to possible occurrence of cryptococcosis of the airway tract in patients with asthma treated with high-dose inhaled corti...
Source: Internal Medicine - April 5, 2021 Category: Internal Medicine Authors: Kohei Yoshimine Kazunori Tobino Mitsukuni Sakabe Ryunosuke Ooi Source Type: research

Dramatic Response to Carboplatin Plus Paclitaxel in Pancreatic Mucinous Cystadenocarcinoma with Liver Metastasis
Intern Med. 2021 Apr 5. doi: 10.2169/internalmedicine.6730-20. Online ahead of print.ABSTRACTMucinous cystic neoplasm (MCN) of the pancreas is a rare cystic tumor occurring in the pancreatic body and tail in young to middle-aged women that is pathologically characterized by an ovarian-like stroma. Chemotherapy for recurrent/advanced pancreatic MCN has been based on chemotherapy regimens for pancreatic ductal adenocarcinoma, but the prognosis is poor. We herein report a 37-year-old woman with pancreatic mucinous cystadenocarcinoma with liver metastasis that responded dramatically to carboplatin plus paclitaxel therapy (CBDC...
Source: Internal Medicine - April 5, 2021 Category: Internal Medicine Authors: Naohiro Oda Masahiro Tabata Masatoshi Uno Yuzo Umeda Hironari Kato Toshio Kubo Satoru Senoo Takahito Yagi Toshiyoshi Fujiwara Yoshinobu Maeda Katsuyuki Kiura Source Type: research

Salvage Cord Blood Transplantation for Sustained Remission of Acute Megakaryoblastic Leukemia That Relapsed Early after Myeloablative Transplantation
Intern Med. 2021 Apr 5. doi: 10.2169/internalmedicine.6796-20. Online ahead of print.ABSTRACTAcute megakaryoblastic leukemia (AMKL) is a rare subtype of acute myeloid leukemia accompanied by an aggressive clinical course and dismal prognosis. We herein report a case of AMKL preceded by mediastinal germ cell tumor that relapsed early after allogeneic hematopoietic stem cell transplantation with myeloablative conditioning but was successfully treated using salvage cord blood transplantation (CBT) with reduced-intensity conditioning. Although several serious complications developed, sustained remission with a favorable genera...
Source: Internal Medicine - April 5, 2021 Category: Internal Medicine Authors: Satoshi Ichikawa Tohru Fujiwara Kei Saito Kazuki Sakurai Kyoko Inokura Noriko Fukuhara Hisayuki Yokoyama Koichi Onodera Yasushi Onishi Junichi Kameoka Hideo Harigae Source Type: research

Tracheobronchopathia Osteochondroplastica Complicated with Mycobacteroides abscessus Pulmonary Disease
Intern Med. 2021 Apr 5. doi: 10.2169/internalmedicine.6844-20. Online ahead of print.NO ABSTRACTPMID:33814496 | DOI:10.2169/internalmedicine.6844-20 (Source: Internal Medicine)
Source: Internal Medicine - April 5, 2021 Category: Internal Medicine Authors: Seiji Yoshida Shun Morizumi Kenya Sumitomo Tsutomu Shinohara Source Type: research

Sternoclavicular Joint Hypertrophy Involved in Polymyalgia Rheumatica
Intern Med. 2021 Apr 5. doi: 10.2169/internalmedicine.6860-20. Online ahead of print.NO ABSTRACTPMID:33814497 | DOI:10.2169/internalmedicine.6860-20 (Source: Internal Medicine)
Source: Internal Medicine - April 5, 2021 Category: Internal Medicine Authors: Koichiro Yamamoto Kosuke Oka Kou Hasegawa Fumio Otsuka Source Type: research

Three Cases of Esophageal Cancer Related to Fanconi Anemia
Intern Med. 2021 Apr 5. doi: 10.2169/internalmedicine.6926-20. Online ahead of print.ABSTRACTThe risk of carcinogenesis increases after 20 years old in patients with Fanconi anemia (FA). We herein report three rare cases of FA combined with esophageal cancer in women; all patients were diagnosed with FA in early childhood. Patients 1 and 2 were diagnosed with advanced and superficial esophageal cancer, respectively, at 21 and 30 years old, respectively. Patient 3 was diagnosed with superficial esophageal cancer, underwent curative surgery at 26 years old, and survived for over 5 years without recurrence. Therefore, establi...
Source: Internal Medicine - April 5, 2021 Category: Internal Medicine Authors: Mia Fujisawa Masashi Matsushima Takashi Ueda Motoki Kaneko Ryutaro Fujimoto Masaya Sano Erika Teramura Makiko Monma Hajime Mizukami Fumio Nakahara Hidekazu Suzuki Takayoshi Suzuki Miharu Yabe Toshimasa Yabe Source Type: research

A Novel Mutation in LMX1B (p.Pro219Ala) Causes Focal Segmental Glomerulosclerosis with Alport Syndrome-like Phenotype
Intern Med. 2021 Apr 5. doi: 10.2169/internalmedicine.6987-20. Online ahead of print.ABSTRACTA 69-year-old woman presented with mild renal dysfunction, proteinuria, and sensorineural hearing loss. A renal biopsy showed focal segmental glomerulosclerosis with thinning of the glomerular basement membrane. There was a positive family history of end-stage kidney disease and hearing loss. Although Alport syndrome was suspected from these features, a genetic test using next-generation sequencer identified a novel missense mutation in LMX1B, c.655C>G: p. (Pro219Ala). In silico analyses predicted the pathogenicity of the mutati...
Source: Internal Medicine - April 5, 2021 Category: Internal Medicine Authors: Yuji Oe Eikan Mishima Takayasu Mori Koji Okamoto Yohei Honkura Tasuku Nagasawa Mai Yoshida Hiroshi Sato Jun Suzuki Ryoukichi Ikeda Eisei Sohara Shinichi Uchida Yukio Katori Mariko Miyazaki Source Type: research

BCR/ABL1-positive B-lymphoblastic Lymphoma Successfully Treated with Dasatinib-combined Chemotherapy
Intern Med. 2021 Apr 5. doi: 10.2169/internalmedicine.7066-21. Online ahead of print.ABSTRACTWe herein report a rare case of BCR-ABL1-positive B-lymphoblastic lymphoma (B-LBL). An 18-year-old woman had a history of persistent left-sided chest pain. Positron emission tomography showed increased metabolic activity in the fifth rib, duodenum, and pancreas. The pathological findings of the pancreas, duodenum, and bone marrow confirmed the diagnosis of B-LBL. Polymerase chain reaction of duodenum and bone marrow also revealed a minor BCR-ABL1 fusion gene. She was diagnosed with BCR-ABL1-positive B-LBL and administered dasatinib...
Source: Internal Medicine - April 5, 2021 Category: Internal Medicine Authors: Chika Yamada Yoshimitsu Shimomura Kimimori Kamijyo Madoka Kanda-Kato Satoshi Yoshioka Daisuke Yamashita Takayuki Ishikawa Source Type: research

Epigastric Pain Three Months after Laparoscopic Cholecystectomy
Intern Med. 2021 Apr 5. doi: 10.2169/internalmedicine.7123-21. Online ahead of print.NO ABSTRACTPMID:33814501 | DOI:10.2169/internalmedicine.7123-21 (Source: Internal Medicine)
Source: Internal Medicine - April 5, 2021 Category: Internal Medicine Authors: Takahiro Inoue Toshinao Itani Source Type: research

Herpes Zoster Brachial Plexopathy with a Dorsal Horn Lesion
Intern Med. 2021 Apr 5. doi: 10.2169/internalmedicine.7171-21. Online ahead of print.NO ABSTRACTPMID:33814502 | DOI:10.2169/internalmedicine.7171-21 (Source: Internal Medicine)
Source: Internal Medicine - April 5, 2021 Category: Internal Medicine Authors: Gohei Yamada Takanari Toyoda Eiichi Katada Noriyuki Matsukawa Source Type: research

Nodal Peripheral T-cell Lymphoma with T Follicular Helper Phenotype Presenting as Chorea during Treatment: A Case Report and Literature Review
Intern Med. 2021 Apr 5. doi: 10.2169/internalmedicine.7180-21. Online ahead of print.ABSTRACTA 72-year-old man presented with chorea while undergoing treatment for recurrence of nodal peripheral T-cell lymphoma with T follicular helper (TFH) phenotype. An examination by brain N-isopropyl-p-iodoamphetamine (123I-IMP)-single photon emission computed tomography (SPECT) revealed no abnormalities other than a decreased cerebral blood flow (CBF) in the left striatum. After four courses of salvage chemotherapy, his clinical symptoms and asymmetric cerebral perfusion improved, suggesting that the decreased CBF had caused chorea. T...
Source: Internal Medicine - April 5, 2021 Category: Internal Medicine Authors: Wataru Kitamura Daisuke Ennishi Ryoya Yukawa Ryo Sasaki Chikamasa Yoshida Hiroki Takasuka Hideaki Fujiwara Noboru Asada Hisakazu Nishimori Keiko Fujii Nobuharu Fujii Ken-Ichi Matsuoka Koji Abe Tadashi Yoshino Yoshinobu Maeda Source Type: research

Could Minocycline be a "Magic Bullet" for the Treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome?
Intern Med. 2021 Apr 5. doi: 10.2169/internalmedicine.7182-21. Online ahead of print.NO ABSTRACTPMID:33814504 | DOI:10.2169/internalmedicine.7182-21 (Source: Internal Medicine)
Source: Internal Medicine - April 5, 2021 Category: Internal Medicine Authors: Takehiro Numata Source Type: research

Diffuse Esophageal Wall Thickening Due to Lymphoma
Intern Med. 2021 Apr 5. doi: 10.2169/internalmedicine.7307-21. Online ahead of print.NO ABSTRACTPMID:33814505 | DOI:10.2169/internalmedicine.7307-21 (Source: Internal Medicine)
Source: Internal Medicine - April 5, 2021 Category: Internal Medicine Authors: Masaya Iwamuro Ken-Ichi Matsuoka Takehiro Tanaka Hiroyuki Okada Source Type: research

Symptomatic Sinus Bradycardia in a Patient with Solitary Fibrous Tumor/Hemangiopericytoma Treated with Pazopanib
Intern Med. 2021 Apr 5. doi: 10.2169/internalmedicine.5347-20. Online ahead of print.ABSTRACTPazopanib, a multi-targeted tyrosine kinase inhibitor, is associated with cardiovascular adverse events, such as hypertension, cardiac dysfunction, and thromboembolism. However, symptomatic pazopanib-related bradycardia is uncommon. We herein report a case of symptomatic bradycardia of 35 beats per minute in a patient with solitary fibrous tumor/hemangiopericytoma (SFT/HPC) treated with pazopanib for 1 month. His heart rate recovered to a normal range soon after pazopanib cessation. He restarted pazopanib at a reduced dose, which w...
Source: Internal Medicine - April 5, 2021 Category: Internal Medicine Authors: Wataru Shioyama Toru Oka Risa Kamada Toshinari Yagi Katsuhiko Nakanishi Tatsuya Nishikawa Taku Yasui Masashi Fujita Source Type: research

Clinico-radiologic Characteristics of Pulmonary Visceral Larva Migrans Caused by Ascaris suum
Conclusion Consumption of raw organic vegetables or raw meat is a possible route of A. suum infection. Infected patients exhibit mild respiratory symptoms, and multiple nodules with a halo in the subpleural area are a common finding on chest HRCT. Treatment with albendazole was effective in these cases.PMID:33814489 | DOI:10.2169/internalmedicine.6109-20 (Source: Internal Medicine)
Source: Internal Medicine - April 5, 2021 Category: Internal Medicine Authors: Nobuhiro Matsumoto Hironobu Tsubouchi Kensuke Setoguchi Takanori Horiguchi Takafumi Shigekusa Shinpei Tsuchida Ayako Matsuo Yasuharu Oda Shigehisa Yanagi Haruhiko Maruyama Masamitsu Nakazato Source Type: research

A Case of Birt-Hogg-Dub é Syndrome with Renal Cancer Treated as Multiple Metastases of Cancer of Unknown Primary
Intern Med. 2021 Apr 5. doi: 10.2169/internalmedicine.6309-20. Online ahead of print.ABSTRACTA 60-year-old woman presented with multiple lung and bone metastases with unknown primary cancer. Chest CT images showed multiple pulmonary cysts, predominantly of the middle and lower lobes. She also had a history of pneumothorax. Four years after chemotherapy and radiation therapy, multiple hypervascular tumors eventually developed in the bilateral kidneys, suggesting the possibility of Birt-Hogg-Dube (BHD) syndrome. Genetic testing revealed a folliculin mutation, which confirmed the diagnosis of BHD syndrome. When we encounter c...
Source: Internal Medicine - April 5, 2021 Category: Internal Medicine Authors: Natsuko Atsukawa Toshinari Yagi Chiaki Kubo Katsuyuki Nakanishi Keigo Osuga Source Type: research

Self-remitting Elevation of Adenosine Deaminase Levels in the Cerebrospinal Fluid with Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy: A Case Report and Review of the Literature
Intern Med. 2021 Apr 5. doi: 10.2169/internalmedicine.6457-20. Online ahead of print.ABSTRACTA 29-year-old man presented with a high-grade fever, headache, and urinary retention, in addition to meningeal irritation and myoclonus in his upper extremities. A cerebrospinal fluid (CSF) examination showed pleocytosis and high adenosine deaminase (ADA) levels with no evidence of bacterial infection, including Mycobacterium tuberculosis. T2-weighted brain magnetic resonance imaging showed transient hyper-intensity lesions at the splenium of the corpus callosum (SCC), bilateral putamen, and pons during the course of the disease. T...
Source: Internal Medicine - April 5, 2021 Category: Internal Medicine Authors: Sota Nakamura Teppei Fujioka Shoji Kawashima Takatsune Kawaguchi Masayuki Mizuno Masahiro Omura Kenji Okita Akio Kimura Takayoshi Shimohata Noriyuki Matsukawa Source Type: research

Successful Re-administration of Atezolizumab for a Non-small-cell Lung Cancer Patient after Cardiac Tamponade Development as a Manifestation of Pseudo-progression Induced by Combination Treatment with Atezolizumab and Cytotoxic Chemotherapy
Intern Med. 2021 Apr 5. doi: 10.2169/internalmedicine.6509-20. Online ahead of print.ABSTRACTPseudo-progression is a phenomenon induced by treatment with immune checkpoint inhibitors and is characterized by an increase in tumor size or the appearance of new lesions, followed by tumor regression. However, life-threatening conditions, such as cardiac tamponade, can develop in such patients. We herein report on a 69-year-old man with lung adenocarcinoma who developed cardiac tamponade as a manifestation of pseudo-progression induced by treatment with atezolizumab combined with cytotoxic chemotherapy. After managing the cardia...
Source: Internal Medicine - April 5, 2021 Category: Internal Medicine Authors: Koki Nakashima Yoshiki Demura Masayuki Sato Yuya Fujii Kazunari Igarashi Tamotsu Ishizuka Source Type: research

Cryptococcosis in the Vocal Cords, Trachea, and Bronchi
Intern Med. 2021 Apr 5. doi: 10.2169/internalmedicine.6559-20. Online ahead of print.ABSTRACTLaryngeal and endobronchial cryptococcosis are rare conditions, and to our knowledge, there have been only 23 cases of laryngeal cryptococcosis, and 18 cases of endobronchial cryptococcosis previously reported in the English literature. We herein report an extremely rare case of cryptococcosis with simultaneous laryngeal and endobronchial involvement. This case highlights the importance of paying close attention to possible occurrence of cryptococcosis of the airway tract in patients with asthma treated with high-dose inhaled corti...
Source: Internal Medicine - April 5, 2021 Category: Internal Medicine Authors: Kohei Yoshimine Kazunori Tobino Mitsukuni Sakabe Ryunosuke Ooi Source Type: research

Dramatic Response to Carboplatin Plus Paclitaxel in Pancreatic Mucinous Cystadenocarcinoma with Liver Metastasis
Intern Med. 2021 Apr 5. doi: 10.2169/internalmedicine.6730-20. Online ahead of print.ABSTRACTMucinous cystic neoplasm (MCN) of the pancreas is a rare cystic tumor occurring in the pancreatic body and tail in young to middle-aged women that is pathologically characterized by an ovarian-like stroma. Chemotherapy for recurrent/advanced pancreatic MCN has been based on chemotherapy regimens for pancreatic ductal adenocarcinoma, but the prognosis is poor. We herein report a 37-year-old woman with pancreatic mucinous cystadenocarcinoma with liver metastasis that responded dramatically to carboplatin plus paclitaxel therapy (CBDC...
Source: Internal Medicine - April 5, 2021 Category: Internal Medicine Authors: Naohiro Oda Masahiro Tabata Masatoshi Uno Yuzo Umeda Hironari Kato Toshio Kubo Satoru Senoo Takahito Yagi Toshiyoshi Fujiwara Yoshinobu Maeda Katsuyuki Kiura Source Type: research

Salvage Cord Blood Transplantation for Sustained Remission of Acute Megakaryoblastic Leukemia That Relapsed Early after Myeloablative Transplantation
Intern Med. 2021 Apr 5. doi: 10.2169/internalmedicine.6796-20. Online ahead of print.ABSTRACTAcute megakaryoblastic leukemia (AMKL) is a rare subtype of acute myeloid leukemia accompanied by an aggressive clinical course and dismal prognosis. We herein report a case of AMKL preceded by mediastinal germ cell tumor that relapsed early after allogeneic hematopoietic stem cell transplantation with myeloablative conditioning but was successfully treated using salvage cord blood transplantation (CBT) with reduced-intensity conditioning. Although several serious complications developed, sustained remission with a favorable genera...
Source: Internal Medicine - April 5, 2021 Category: Internal Medicine Authors: Satoshi Ichikawa Tohru Fujiwara Kei Saito Kazuki Sakurai Kyoko Inokura Noriko Fukuhara Hisayuki Yokoyama Koichi Onodera Yasushi Onishi Junichi Kameoka Hideo Harigae Source Type: research

Tracheobronchopathia Osteochondroplastica Complicated with Mycobacteroides abscessus Pulmonary Disease
Intern Med. 2021 Apr 5. doi: 10.2169/internalmedicine.6844-20. Online ahead of print.NO ABSTRACTPMID:33814496 | DOI:10.2169/internalmedicine.6844-20 (Source: Internal Medicine)
Source: Internal Medicine - April 5, 2021 Category: Internal Medicine Authors: Seiji Yoshida Shun Morizumi Kenya Sumitomo Tsutomu Shinohara Source Type: research

Sternoclavicular Joint Hypertrophy Involved in Polymyalgia Rheumatica
Intern Med. 2021 Apr 5. doi: 10.2169/internalmedicine.6860-20. Online ahead of print.NO ABSTRACTPMID:33814497 | DOI:10.2169/internalmedicine.6860-20 (Source: Internal Medicine)
Source: Internal Medicine - April 5, 2021 Category: Internal Medicine Authors: Koichiro Yamamoto Kosuke Oka Kou Hasegawa Fumio Otsuka Source Type: research

Three Cases of Esophageal Cancer Related to Fanconi Anemia
Intern Med. 2021 Apr 5. doi: 10.2169/internalmedicine.6926-20. Online ahead of print.ABSTRACTThe risk of carcinogenesis increases after 20 years old in patients with Fanconi anemia (FA). We herein report three rare cases of FA combined with esophageal cancer in women; all patients were diagnosed with FA in early childhood. Patients 1 and 2 were diagnosed with advanced and superficial esophageal cancer, respectively, at 21 and 30 years old, respectively. Patient 3 was diagnosed with superficial esophageal cancer, underwent curative surgery at 26 years old, and survived for over 5 years without recurrence. Therefore, establi...
Source: Internal Medicine - April 5, 2021 Category: Internal Medicine Authors: Mia Fujisawa Masashi Matsushima Takashi Ueda Motoki Kaneko Ryutaro Fujimoto Masaya Sano Erika Teramura Makiko Monma Hajime Mizukami Fumio Nakahara Hidekazu Suzuki Takayoshi Suzuki Miharu Yabe Toshimasa Yabe Source Type: research

A Novel Mutation in LMX1B (p.Pro219Ala) Causes Focal Segmental Glomerulosclerosis with Alport Syndrome-like Phenotype
Intern Med. 2021 Apr 5. doi: 10.2169/internalmedicine.6987-20. Online ahead of print.ABSTRACTA 69-year-old woman presented with mild renal dysfunction, proteinuria, and sensorineural hearing loss. A renal biopsy showed focal segmental glomerulosclerosis with thinning of the glomerular basement membrane. There was a positive family history of end-stage kidney disease and hearing loss. Although Alport syndrome was suspected from these features, a genetic test using next-generation sequencer identified a novel missense mutation in LMX1B, c.655C>G: p. (Pro219Ala). In silico analyses predicted the pathogenicity of the mutati...
Source: Internal Medicine - April 5, 2021 Category: Internal Medicine Authors: Yuji Oe Eikan Mishima Takayasu Mori Koji Okamoto Yohei Honkura Tasuku Nagasawa Mai Yoshida Hiroshi Sato Jun Suzuki Ryoukichi Ikeda Eisei Sohara Shinichi Uchida Yukio Katori Mariko Miyazaki Source Type: research

BCR/ABL1-positive B-lymphoblastic Lymphoma Successfully Treated with Dasatinib-combined Chemotherapy
Intern Med. 2021 Apr 5. doi: 10.2169/internalmedicine.7066-21. Online ahead of print.ABSTRACTWe herein report a rare case of BCR-ABL1-positive B-lymphoblastic lymphoma (B-LBL). An 18-year-old woman had a history of persistent left-sided chest pain. Positron emission tomography showed increased metabolic activity in the fifth rib, duodenum, and pancreas. The pathological findings of the pancreas, duodenum, and bone marrow confirmed the diagnosis of B-LBL. Polymerase chain reaction of duodenum and bone marrow also revealed a minor BCR-ABL1 fusion gene. She was diagnosed with BCR-ABL1-positive B-LBL and administered dasatinib...
Source: Internal Medicine - April 5, 2021 Category: Internal Medicine Authors: Chika Yamada Yoshimitsu Shimomura Kimimori Kamijyo Madoka Kanda-Kato Satoshi Yoshioka Daisuke Yamashita Takayuki Ishikawa Source Type: research

Epigastric Pain Three Months after Laparoscopic Cholecystectomy
Intern Med. 2021 Apr 5. doi: 10.2169/internalmedicine.7123-21. Online ahead of print.NO ABSTRACTPMID:33814501 | DOI:10.2169/internalmedicine.7123-21 (Source: Internal Medicine)
Source: Internal Medicine - April 5, 2021 Category: Internal Medicine Authors: Takahiro Inoue Toshinao Itani Source Type: research

Herpes Zoster Brachial Plexopathy with a Dorsal Horn Lesion
Intern Med. 2021 Apr 5. doi: 10.2169/internalmedicine.7171-21. Online ahead of print.NO ABSTRACTPMID:33814502 | DOI:10.2169/internalmedicine.7171-21 (Source: Internal Medicine)
Source: Internal Medicine - April 5, 2021 Category: Internal Medicine Authors: Gohei Yamada Takanari Toyoda Eiichi Katada Noriyuki Matsukawa Source Type: research

Nodal Peripheral T-cell Lymphoma with T Follicular Helper Phenotype Presenting as Chorea during Treatment: A Case Report and Literature Review
Intern Med. 2021 Apr 5. doi: 10.2169/internalmedicine.7180-21. Online ahead of print.ABSTRACTA 72-year-old man presented with chorea while undergoing treatment for recurrence of nodal peripheral T-cell lymphoma with T follicular helper (TFH) phenotype. An examination by brain N-isopropyl-p-iodoamphetamine (123I-IMP)-single photon emission computed tomography (SPECT) revealed no abnormalities other than a decreased cerebral blood flow (CBF) in the left striatum. After four courses of salvage chemotherapy, his clinical symptoms and asymmetric cerebral perfusion improved, suggesting that the decreased CBF had caused chorea. T...
Source: Internal Medicine - April 5, 2021 Category: Internal Medicine Authors: Wataru Kitamura Daisuke Ennishi Ryoya Yukawa Ryo Sasaki Chikamasa Yoshida Hiroki Takasuka Hideaki Fujiwara Noboru Asada Hisakazu Nishimori Keiko Fujii Nobuharu Fujii Ken-Ichi Matsuoka Koji Abe Tadashi Yoshino Yoshinobu Maeda Source Type: research

Could Minocycline be a "Magic Bullet" for the Treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome?
Intern Med. 2021 Apr 5. doi: 10.2169/internalmedicine.7182-21. Online ahead of print.NO ABSTRACTPMID:33814504 | DOI:10.2169/internalmedicine.7182-21 (Source: Internal Medicine)
Source: Internal Medicine - April 5, 2021 Category: Internal Medicine Authors: Takehiro Numata Source Type: research

Diffuse Esophageal Wall Thickening Due to Lymphoma
Intern Med. 2021 Apr 5. doi: 10.2169/internalmedicine.7307-21. Online ahead of print.NO ABSTRACTPMID:33814505 | DOI:10.2169/internalmedicine.7307-21 (Source: Internal Medicine)
Source: Internal Medicine - April 5, 2021 Category: Internal Medicine Authors: Masaya Iwamuro Ken-Ichi Matsuoka Takehiro Tanaka Hiroyuki Okada Source Type: research

Symptomatic Sinus Bradycardia in a Patient with Solitary Fibrous Tumor/Hemangiopericytoma Treated with Pazopanib
Intern Med. 2021 Apr 5. doi: 10.2169/internalmedicine.5347-20. Online ahead of print.ABSTRACTPazopanib, a multi-targeted tyrosine kinase inhibitor, is associated with cardiovascular adverse events, such as hypertension, cardiac dysfunction, and thromboembolism. However, symptomatic pazopanib-related bradycardia is uncommon. We herein report a case of symptomatic bradycardia of 35 beats per minute in a patient with solitary fibrous tumor/hemangiopericytoma (SFT/HPC) treated with pazopanib for 1 month. His heart rate recovered to a normal range soon after pazopanib cessation. He restarted pazopanib at a reduced dose, which w...
Source: Internal Medicine - April 5, 2021 Category: Internal Medicine Authors: Wataru Shioyama Toru Oka Risa Kamada Toshinari Yagi Katsuhiko Nakanishi Tatsuya Nishikawa Taku Yasui Masashi Fujita Source Type: research

Clinico-radiologic Characteristics of Pulmonary Visceral Larva Migrans Caused by Ascaris suum
Conclusion Consumption of raw organic vegetables or raw meat is a possible route of A. suum infection. Infected patients exhibit mild respiratory symptoms, and multiple nodules with a halo in the subpleural area are a common finding on chest HRCT. Treatment with albendazole was effective in these cases.PMID:33814489 | DOI:10.2169/internalmedicine.6109-20 (Source: Internal Medicine)
Source: Internal Medicine - April 5, 2021 Category: Internal Medicine Authors: Nobuhiro Matsumoto Hironobu Tsubouchi Kensuke Setoguchi Takanori Horiguchi Takafumi Shigekusa Shinpei Tsuchida Ayako Matsuo Yasuharu Oda Shigehisa Yanagi Haruhiko Maruyama Masamitsu Nakazato Source Type: research

A Case of Birt-Hogg-Dub é Syndrome with Renal Cancer Treated as Multiple Metastases of Cancer of Unknown Primary
Intern Med. 2021 Apr 5. doi: 10.2169/internalmedicine.6309-20. Online ahead of print.ABSTRACTA 60-year-old woman presented with multiple lung and bone metastases with unknown primary cancer. Chest CT images showed multiple pulmonary cysts, predominantly of the middle and lower lobes. She also had a history of pneumothorax. Four years after chemotherapy and radiation therapy, multiple hypervascular tumors eventually developed in the bilateral kidneys, suggesting the possibility of Birt-Hogg-Dube (BHD) syndrome. Genetic testing revealed a folliculin mutation, which confirmed the diagnosis of BHD syndrome. When we encounter c...
Source: Internal Medicine - April 5, 2021 Category: Internal Medicine Authors: Natsuko Atsukawa Toshinari Yagi Chiaki Kubo Katsuyuki Nakanishi Keigo Osuga Source Type: research

Self-remitting Elevation of Adenosine Deaminase Levels in the Cerebrospinal Fluid with Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy: A Case Report and Review of the Literature
Intern Med. 2021 Apr 5. doi: 10.2169/internalmedicine.6457-20. Online ahead of print.ABSTRACTA 29-year-old man presented with a high-grade fever, headache, and urinary retention, in addition to meningeal irritation and myoclonus in his upper extremities. A cerebrospinal fluid (CSF) examination showed pleocytosis and high adenosine deaminase (ADA) levels with no evidence of bacterial infection, including Mycobacterium tuberculosis. T2-weighted brain magnetic resonance imaging showed transient hyper-intensity lesions at the splenium of the corpus callosum (SCC), bilateral putamen, and pons during the course of the disease. T...
Source: Internal Medicine - April 5, 2021 Category: Internal Medicine Authors: Sota Nakamura Teppei Fujioka Shoji Kawashima Takatsune Kawaguchi Masayuki Mizuno Masahiro Omura Kenji Okita Akio Kimura Takayoshi Shimohata Noriyuki Matsukawa Source Type: research

Successful Re-administration of Atezolizumab for a Non-small-cell Lung Cancer Patient after Cardiac Tamponade Development as a Manifestation of Pseudo-progression Induced by Combination Treatment with Atezolizumab and Cytotoxic Chemotherapy
Intern Med. 2021 Apr 5. doi: 10.2169/internalmedicine.6509-20. Online ahead of print.ABSTRACTPseudo-progression is a phenomenon induced by treatment with immune checkpoint inhibitors and is characterized by an increase in tumor size or the appearance of new lesions, followed by tumor regression. However, life-threatening conditions, such as cardiac tamponade, can develop in such patients. We herein report on a 69-year-old man with lung adenocarcinoma who developed cardiac tamponade as a manifestation of pseudo-progression induced by treatment with atezolizumab combined with cytotoxic chemotherapy. After managing the cardia...
Source: Internal Medicine - April 5, 2021 Category: Internal Medicine Authors: Koki Nakashima Yoshiki Demura Masayuki Sato Yuya Fujii Kazunari Igarashi Tamotsu Ishizuka Source Type: research

Cryptococcosis in the Vocal Cords, Trachea, and Bronchi
Intern Med. 2021 Apr 5. doi: 10.2169/internalmedicine.6559-20. Online ahead of print.ABSTRACTLaryngeal and endobronchial cryptococcosis are rare conditions, and to our knowledge, there have been only 23 cases of laryngeal cryptococcosis, and 18 cases of endobronchial cryptococcosis previously reported in the English literature. We herein report an extremely rare case of cryptococcosis with simultaneous laryngeal and endobronchial involvement. This case highlights the importance of paying close attention to possible occurrence of cryptococcosis of the airway tract in patients with asthma treated with high-dose inhaled corti...
Source: Internal Medicine - April 5, 2021 Category: Internal Medicine Authors: Kohei Yoshimine Kazunori Tobino Mitsukuni Sakabe Ryunosuke Ooi Source Type: research

Dramatic Response to Carboplatin Plus Paclitaxel in Pancreatic Mucinous Cystadenocarcinoma with Liver Metastasis
Intern Med. 2021 Apr 5. doi: 10.2169/internalmedicine.6730-20. Online ahead of print.ABSTRACTMucinous cystic neoplasm (MCN) of the pancreas is a rare cystic tumor occurring in the pancreatic body and tail in young to middle-aged women that is pathologically characterized by an ovarian-like stroma. Chemotherapy for recurrent/advanced pancreatic MCN has been based on chemotherapy regimens for pancreatic ductal adenocarcinoma, but the prognosis is poor. We herein report a 37-year-old woman with pancreatic mucinous cystadenocarcinoma with liver metastasis that responded dramatically to carboplatin plus paclitaxel therapy (CBDC...
Source: Internal Medicine - April 5, 2021 Category: Internal Medicine Authors: Naohiro Oda Masahiro Tabata Masatoshi Uno Yuzo Umeda Hironari Kato Toshio Kubo Satoru Senoo Takahito Yagi Toshiyoshi Fujiwara Yoshinobu Maeda Katsuyuki Kiura Source Type: research

Salvage Cord Blood Transplantation for Sustained Remission of Acute Megakaryoblastic Leukemia That Relapsed Early after Myeloablative Transplantation
Intern Med. 2021 Apr 5. doi: 10.2169/internalmedicine.6796-20. Online ahead of print.ABSTRACTAcute megakaryoblastic leukemia (AMKL) is a rare subtype of acute myeloid leukemia accompanied by an aggressive clinical course and dismal prognosis. We herein report a case of AMKL preceded by mediastinal germ cell tumor that relapsed early after allogeneic hematopoietic stem cell transplantation with myeloablative conditioning but was successfully treated using salvage cord blood transplantation (CBT) with reduced-intensity conditioning. Although several serious complications developed, sustained remission with a favorable genera...
Source: Internal Medicine - April 5, 2021 Category: Internal Medicine Authors: Satoshi Ichikawa Tohru Fujiwara Kei Saito Kazuki Sakurai Kyoko Inokura Noriko Fukuhara Hisayuki Yokoyama Koichi Onodera Yasushi Onishi Junichi Kameoka Hideo Harigae Source Type: research

Tracheobronchopathia Osteochondroplastica Complicated with Mycobacteroides abscessus Pulmonary Disease
Intern Med. 2021 Apr 5. doi: 10.2169/internalmedicine.6844-20. Online ahead of print.NO ABSTRACTPMID:33814496 | DOI:10.2169/internalmedicine.6844-20 (Source: Internal Medicine)
Source: Internal Medicine - April 5, 2021 Category: Internal Medicine Authors: Seiji Yoshida Shun Morizumi Kenya Sumitomo Tsutomu Shinohara Source Type: research

Sternoclavicular Joint Hypertrophy Involved in Polymyalgia Rheumatica
Intern Med. 2021 Apr 5. doi: 10.2169/internalmedicine.6860-20. Online ahead of print.NO ABSTRACTPMID:33814497 | DOI:10.2169/internalmedicine.6860-20 (Source: Internal Medicine)
Source: Internal Medicine - April 5, 2021 Category: Internal Medicine Authors: Koichiro Yamamoto Kosuke Oka Kou Hasegawa Fumio Otsuka Source Type: research

Three Cases of Esophageal Cancer Related to Fanconi Anemia
Intern Med. 2021 Apr 5. doi: 10.2169/internalmedicine.6926-20. Online ahead of print.ABSTRACTThe risk of carcinogenesis increases after 20 years old in patients with Fanconi anemia (FA). We herein report three rare cases of FA combined with esophageal cancer in women; all patients were diagnosed with FA in early childhood. Patients 1 and 2 were diagnosed with advanced and superficial esophageal cancer, respectively, at 21 and 30 years old, respectively. Patient 3 was diagnosed with superficial esophageal cancer, underwent curative surgery at 26 years old, and survived for over 5 years without recurrence. Therefore, establi...
Source: Internal Medicine - April 5, 2021 Category: Internal Medicine Authors: Mia Fujisawa Masashi Matsushima Takashi Ueda Motoki Kaneko Ryutaro Fujimoto Masaya Sano Erika Teramura Makiko Monma Hajime Mizukami Fumio Nakahara Hidekazu Suzuki Takayoshi Suzuki Miharu Yabe Toshimasa Yabe Source Type: research

A Novel Mutation in LMX1B (p.Pro219Ala) Causes Focal Segmental Glomerulosclerosis with Alport Syndrome-like Phenotype
Intern Med. 2021 Apr 5. doi: 10.2169/internalmedicine.6987-20. Online ahead of print.ABSTRACTA 69-year-old woman presented with mild renal dysfunction, proteinuria, and sensorineural hearing loss. A renal biopsy showed focal segmental glomerulosclerosis with thinning of the glomerular basement membrane. There was a positive family history of end-stage kidney disease and hearing loss. Although Alport syndrome was suspected from these features, a genetic test using next-generation sequencer identified a novel missense mutation in LMX1B, c.655C>G: p. (Pro219Ala). In silico analyses predicted the pathogenicity of the mutati...
Source: Internal Medicine - April 5, 2021 Category: Internal Medicine Authors: Yuji Oe Eikan Mishima Takayasu Mori Koji Okamoto Yohei Honkura Tasuku Nagasawa Mai Yoshida Hiroshi Sato Jun Suzuki Ryoukichi Ikeda Eisei Sohara Shinichi Uchida Yukio Katori Mariko Miyazaki Source Type: research

BCR/ABL1-positive B-lymphoblastic Lymphoma Successfully Treated with Dasatinib-combined Chemotherapy
Intern Med. 2021 Apr 5. doi: 10.2169/internalmedicine.7066-21. Online ahead of print.ABSTRACTWe herein report a rare case of BCR-ABL1-positive B-lymphoblastic lymphoma (B-LBL). An 18-year-old woman had a history of persistent left-sided chest pain. Positron emission tomography showed increased metabolic activity in the fifth rib, duodenum, and pancreas. The pathological findings of the pancreas, duodenum, and bone marrow confirmed the diagnosis of B-LBL. Polymerase chain reaction of duodenum and bone marrow also revealed a minor BCR-ABL1 fusion gene. She was diagnosed with BCR-ABL1-positive B-LBL and administered dasatinib...
Source: Internal Medicine - April 5, 2021 Category: Internal Medicine Authors: Chika Yamada Yoshimitsu Shimomura Kimimori Kamijyo Madoka Kanda-Kato Satoshi Yoshioka Daisuke Yamashita Takayuki Ishikawa Source Type: research

Epigastric Pain Three Months after Laparoscopic Cholecystectomy
Intern Med. 2021 Apr 5. doi: 10.2169/internalmedicine.7123-21. Online ahead of print.NO ABSTRACTPMID:33814501 | DOI:10.2169/internalmedicine.7123-21 (Source: Internal Medicine)
Source: Internal Medicine - April 5, 2021 Category: Internal Medicine Authors: Takahiro Inoue Toshinao Itani Source Type: research