Predictive Performance of Radiomic Features Extracted from Breast MR Imaging in Postoperative Upgrading of Ductal Carcinoma in Situ to Invasive Carcinoma
CONCLUSION: A radiomics approach using breast MRI may be a promising method for predicting the postoperative upgrade of DCIS. The present study showed that the radiomic features extracted from pre-contrast T1WI and post-contrast subtraction images in the very early phase of DCE-MRI were more predictable.PMID:38749758 | DOI:10.2463/mrms.mp.2023-0168 (Source: Magnetic Resonance in Medical Sciences : MRMS)
Source: Magnetic Resonance in Medical Sciences : MRMS - May 15, 2024 Category: Radiology Authors: Hiroko Satake Fumie Kinoshita Satoko Ishigaki Keita Kato Yusuke Jo Satoko Shimada Norikazu Masuda Shinji Naganawa Source Type: research
Synergy of nodal factors in predicting recurrence after treatment of N1b papillary thyroid carcinoma
CONCLUSIONS: Nodal factors have synergy effect in predicting recurrence in cN1b PTC patients. Increasing lymph nodes harvest may only decrease recurrence in patients without gENE, while not in gENE patients.PMID:38748619 | DOI:10.1210/clinem/dgae329 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - May 15, 2024 Category: Endocrinology Authors: Keyao Xian Siyuan Xu Hui Huang Chengwei Xing Xiaolei Wang Shaoyan Liu Jie Liu Source Type: research
Hepatitis B: Model Systems and Therapeutic Approaches
J Immunol Res. 2024 May 7;2024:4722047. doi: 10.1155/2024/4722047. eCollection 2024.ABSTRACTHepatitis B virus (HBV) infection is a major global health issue and ranks among the top causes of liver cirrhosis and hepatocellular carcinoma. Although current antiviral medications, including nucleot(s)ide analogs and interferons, could inhibit the replication of HBV and alleviate the disease, HBV cannot be fully eradicated. The development of cellular and animal models for HBV infection plays an important role in exploring effective anti-HBV medicine. During the past decades, advancements in several cell culture systems, such as...
Source: Journal of Immunology Research - May 15, 2024 Category: Allergy & Immunology Authors: Xiaoxiao Yu Yating Gao Xin Zhang Longshan Ji Miao Fang Man Li Yueqiu Gao Source Type: research
End-stage renal disease after renal cancer surgery: risk factors and overall survival
CONCLUSIONS: Patients who developed ESRD following renal cancer surgery had significantly poorer survival outcomes. Advanced age, comorbidities, higher-stage tumours and RN were identified as risk factors for developing ESRD. Surgical decisions are crucial. Efforts to spare renal function, including nephron-sparing surgery and active surveillance in appropriate cases, are highly relevant to reduce the development of severe kidney dysfunction.PMID:38747153 | DOI:10.2340/sju.v59.40322 (Source: Scandinavian Journal of Urology)
Source: Scandinavian Journal of Urology - May 15, 2024 Category: Urology & Nephrology Authors: John Åkerlund B örje Ljungberg Sven Lundstam Ralph Peeker Erik Holmberg Marianne M ånsson Anna Grenabo Bergdahl Source Type: research
Clinicopathologic features and genomic profiling of female axillary lymph node metastases from adenocarcinoma or poorly differentiated carcinoma of unknown primary
CONCLUSIONS: More active treatment methods, like chemotherapy, mastectomy and postoperative radiotherapy, could improve the prognosis of CUPAx. The differential mutation genes of CUPAx and BCAx might be associated with their respective biological behaviors like invasiveness and prognosis.PMID:38750402 | DOI:10.1007/s00432-024-05783-6 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - May 15, 2024 Category: Cancer & Oncology Authors: Liansha Tang Yueting Zhu Yang Du Xiangyu Long Yixiu Long Yuan Tang Jiyan Liu Source Type: research
Exploring the Molecular Mechanisms of Huaier on Modulating Metabolic Reprogramming of Hepatocellular Carcinoma: A Study based on Network Pharmacology, Molecular Docking and Bioinformatics
CONCLUSION: This study provided a workflow for understanding the mechanism of Huaier in regulating the metabolic reprogramming of HCC.PMID:38747231 | DOI:10.2174/0113816128287535240429043610 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - May 15, 2024 Category: Drugs & Pharmacology Authors: Yuxiang Wan Honglin Jiang Zeyu Liu Chen Bai Yanyan Lian Chunguang Zhang Qiaoli Zhang Jinchang Huang Source Type: research
Incidence and trends of first basal cell carcinomas in France between 1980 and 2019: a regional population-based registry study
CONCLUSIONS: BCC incidence has increased since 1980 and is still rising, particularly among men and the elderly. A slowing was observed since 2000, which could be explained by a shift in the management of BCCs and by the possible efficacy of prevention actions. This study provides insight into the BCC burden in France and highlights the need to maintain effective prevention strategies, since incidence is still increasing.PMID:38748494 | DOI:10.1093/bjd/ljae201 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 15, 2024 Category: Dermatology Authors: Karima Hammas Charl ée Nardin S éverine Boyer Catherine Michel Fran çois Aubin Anne-Sophie Woronoff Source Type: research
Comparison of different 2D muscle indexes measured at the level of the 3rd lumbar vertebra in survival prediction in patients with renal cell carcinoma
The objective of this study was to investigate the performance of different MIs for survival prognostication in renal cell carcinoma (RCC).METHODS: We retrospectively enrolled 214 consecutive patients with RCC. We determined three L3-MIs (psoas muscle index (PMI), psoas muscle index and erector spinae index (PMI+ESI), and whole skeletal muscle index (SMI)) from preoperative CT scans. Categorization of those with low and normal muscle mass was based on the Youden Index sex-specific MI cut-offs. We determined sensitivity, specificity, and accuracy metrics for predicting 1-year, 5-year, and overall survival (OS) using Cox reg...
Source: Acta Oncologica - May 15, 2024 Category: Cancer & Oncology Authors: Oona Janhunen Otto Jokelainen Robin Peltoniemi Timo K Nykopp Otso Arponen Source Type: research
ASO Author Reflections: Evaluating NPTXR as a Prognostic Biomarker and Therapeutic Target in Esophageal Squamous Cell Carcinoma
Ann Surg Oncol. 2024 May 15. doi: 10.1245/s10434-024-15425-3. Online ahead of print.NO ABSTRACTPMID:38748292 | DOI:10.1245/s10434-024-15425-3 (Source: Ann Oncol)
Source: Ann Oncol - May 15, 2024 Category: Cancer & Oncology Authors: Takahiro Shinozuka Mitsuro Kanda Yasuhiro Kodera Source Type: research
Fusogenic vesicular stomatitis virus combined with natural killer T cell immunotherapy controls metastatic breast cancer
CONCLUSION: Combining NKT cell immunotherapy with enhanced oncolytic virotherapy increased anti-tumor immune targeting of lung metastasis and presents a promising treatment strategy for metastatic breast cancer.PMID:38750591 | DOI:10.1186/s13058-024-01818-5 (Source: Cancer Control)
Source: Cancer Control - May 15, 2024 Category: Cancer & Oncology Authors: Adam Nelson Nichole McMullen Simon Gebremeskel Roberto De Antueno Duncan Mackenzie Roy Duncan Brent Johnston Source Type: research
Exploring the impact of insufficient thermal ablation on hepatocellular carcinoma: NDST2 overexpression mechanism and its role in facilitating growth and invasion of residual cancer cells
CONCLUSION: The upregulation of NDST2 can accelerate the progression of residual HCC after ITA, suggesting a potential role for NDST2 in the therapeutic efficacy and prognosis of residual HCC.PMID:38749506 | DOI:10.1080/02656736.2024.2353309 (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - May 15, 2024 Category: Internal Medicine Authors: Weijun Wan Danxia Guo Tong Kang Jinshu Pang Yunjing Pan Jiamin Chen Wei Liao Yuji Chen Peng Lin Lipeng Li Hong Yang Yun He Source Type: research
Clinicopathologic features and genomic profiling of female axillary lymph node metastases from adenocarcinoma or poorly differentiated carcinoma of unknown primary
CONCLUSIONS: More active treatment methods, like chemotherapy, mastectomy and postoperative radiotherapy, could improve the prognosis of CUPAx. The differential mutation genes of CUPAx and BCAx might be associated with their respective biological behaviors like invasiveness and prognosis.PMID:38750402 | DOI:10.1007/s00432-024-05783-6 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - May 15, 2024 Category: Cancer & Oncology Authors: Liansha Tang Yueting Zhu Yang Du Xiangyu Long Yixiu Long Yuan Tang Jiyan Liu Source Type: research
Evaluation of BH3 mimetics as a combination therapy with irradiation in head and neck squamous cell carcinoma
CONCLUSIONS: Our findings encourage the further preclinical investigation of BH3 mimetics, particularly A-1331852, as a single agent or combined with irradiation as a treatment for HNSCC.PMID:38749173 | DOI:10.1016/j.biopha.2024.116719 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 15, 2024 Category: Drugs & Pharmacology Authors: Katja Korelin Mayke Oostveen Wafa Wahbi Filipp Ianevski Bruno Cavalcante Laura Turunen Ilya Belevich Ahmed Al-Samadi Tuula Salo Source Type: research
GPC3-targeted CAR-T cells expressing GLUT1 or AGK exhibit enhanced antitumor activity against hepatocellular carcinoma
In this study, we generated GPC3-targeted CAR-T cells overexpressing GLUT1 or AGK for the treatment of HCC. GPC3-targeted CAR-T cells overexpressing GLUT1 or AGK specifically and effectively lysed GPC3-positive tumor cells in vitro in an antigen-dependent manner. Furthermore, GLUT1 or AGK overexpression protected CAR-T cells from apoptosis during repeated exposures to tumor cells. Compared with second-generation CAR-T cells, GPC3-targeted CAR-T cells overexpressing GLUT1 or AGK exhibited greater CD8+ T-cell persistence in vivo and better antitumor effects in HCC allograft mouse models. Finally, we revealed that GLUT1 or AG...
Source: Acta Pharmacologica Sinica - May 15, 2024 Category: Drugs & Pharmacology Authors: Rui-Xin Sun Yi-Fan Liu Yan-Sha Sun Min Zhou Yi Wang Bi-Zhi Shi Hua Jiang Zong-Hai Li Source Type: research
Factors and management techniques in odontogenic keratocysts: a systematic review
CONCLUSION: Among the studies examined, the most common location for these lesions was found to be in the area of the mandibular ramus and the posterior region of the mandible. In cases where the exact location wasn't specified, the mandible emerged as the predominant site. When we considered the characteristics of these lesions in studies that mentioned locularity, most were described as unilocular in two studies, while in two other studies, the prevalence of multilocular lesions was observed. Risk factors associated with keratocyst recurrence include younger patient age, the presence of multilocular lesions, larger lesio...
Source: Cell Research - May 15, 2024 Category: Cytology Authors: Mario Dioguardi Cristian Quarta Diego Sovereto Giorgia Apollonia Caloro Andrea Ballini Riccardo Aiuto Angelo Martella Lorenzo Lo Muzio Michele Di Cosola Source Type: research
