Muscle Mass Affects Paclitaxel Systemic Exposure and May Inform Personalized Paclitaxel Dosing
The objective of this study was to interrogate morphomic parameters as predictors of paclitaxel pharmacokinetics to identify alternative dosing strategies that may improve treatment outcomes.METHODS: This was a secondary analysis of female patients with breast cancer scheduled to receive 80 mg/m2 weekly paclitaxel infusions. Paclitaxel was measured at the end of initial infusion to estimate maximum concentration (Cmax ). Computed tomography (CT) scans were used to measure 29 body composition features for inclusion in pharmacokinetic modeling. Monte Carlo simulations were performed to identify infusion durations that limit ...
Source: Clinical Breast Cancer - January 27, 2022 Category: Cancer & Oncology Authors: Daniel L Hertz Li Chen N Lynn Henry Jennifer J Griggs Daniel F Hayes Brian A Derstine Grace L Su Stewart C Wang Manjunath P Pai Source Type: research

FDA Approval Summary: Abemaciclib With Endocrine Therapy for High-Risk Early Breast Cancer
CONCLUSION: The approval of abemaciclib in adjuvant EBC was limited to patients with high risk of recurrence and Ki-67 ≥ 20%, given their favorable benefit:risk with a statistically significant IDFS advantage and no observed detriment on survival.PMID:35084948 | DOI:10.1200/JCO.21.02742 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - January 27, 2022 Category: Cancer & Oncology Authors: Melanie Royce Christy Osgood Flora Mulkey Erik Bloomquist William F Pierce Arpita Roy Shyam Kalavar Soma Ghosh Reena Philip Fatima Rizvi Bronwyn D Mixter Shenghui Tang Richard Pazdur Julia A Beaver Laleh Amiri-Kordestani Source Type: research

Smad3 methylation by EZH2 promotes its activation and tumor metastasis
J Clin Invest. 2022 Jan 27:e152394. doi: 10.1172/JCI152394. Online ahead of print.ABSTRACTSMAD3 plays a central role in cancer metastasis, and its hyperactivation is linked to poor cancer outcomes. Thus, it is critical to understand the upstream signaling pathways that govern SMAD3 activation. Here, we report that SMAD3 undergoes methylation at K53 and K333 by EZH2, a process crucial for cell membrane recruitment, phosphorylation, and activation of SMAD3 upon TGFB1 stimulation. Mechanistically, EZH2-triggered SMAD3 methylation facilitates SMAD3 interaction with its cellular membrane localization molecule (SARA), which in t...
Source: Clinical Breast Cancer - January 27, 2022 Category: Cancer & Oncology Authors: Changsheng Huang Fuqing Hu Da Song Xuling Sun Anyi Liu Qi Wu Xiaowei She Yaqi Chen Lisheng Chen Fayong Hu Feng Xu Xuelai Luo Yongdong Feng Xiangping Yang Junbo Hu Guihua Wang Source Type: research

Associations between Spiritual Health Locus of Control, Perceived Discrimination and Breast and Cervical Cancer Screening for Muslim American Women in New York City
CONCLUSION: The spiritual beliefs of Muslim American women impact their likelihood of obtaining breast and cervical cancer screenings. Therefore, these services need to be better tailored to match these needs, for example, by ensuring that Muslim American women have access to healthcare providers of their same gender, race, ethnicity or religion.PMID:35078722 | DOI:10.1016/j.clbc.2021.12.012 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - January 26, 2022 Category: Cancer & Oncology Authors: Sameena Azhar Laura C Wyatt Vaidehi Jokhakar Shilpa Patel Victoria H Raveis Simona C Kwon Nadia S Islam Source Type: research

Effects of Whole Pelvic Radiotherapy on the Distribution of Lymphocyte Subpopulations in Prostate Cancer Patients
CONCLUSION: Our results could be used to design a prospective trial in order to study the use of WPRT on the lymphocyte subpopulations.PMID:35081052 | DOI:10.1097/COC.0000000000000894 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - January 26, 2022 Category: Cancer & Oncology Authors: Giandomenico Roviello Valerio Nardone Alberto Bonetta Pierpaolo Correale Alfredo Molteni Maria C Lazzari Daniele Generali Source Type: research

68Ga-DOTA-FAPI-04 Uptake of Accessory Breast in a Patient With Breast Cancer
Clin Nucl Med. 2022 Jan 24. doi: 10.1097/RLU.0000000000004069. Online ahead of print.ABSTRACT68Ga-DOTA-FAPI-04 is a promising PET agent for tumor imaging. However, some nonneoplastic lesions can also show increased FAPI uptake. Herein, we presented a case of a patient with left breast cancer who showed a right accessory breast with increased tracer uptake on 68Ga-DOTA-FAPI-04 PET/CT. Final histopathology confirmed there were no malignant components in the accessory breast.PMID:35081060 | DOI:10.1097/RLU.0000000000004069 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - January 26, 2022 Category: Cancer & Oncology Authors: Tingting Xu Wei Wang Chuan Yang Liang Cai Yue Chen Source Type: research

Associations between Spiritual Health Locus of Control, Perceived Discrimination and Breast and Cervical Cancer Screening for Muslim American Women in New York City
CONCLUSION: The spiritual beliefs of Muslim American women impact their likelihood of obtaining breast and cervical cancer screenings. Therefore, these services need to be better tailored to match these needs, for example, by ensuring that Muslim American women have access to healthcare providers of their same gender, race, ethnicity or religion.PMID:35078722 | DOI:10.1016/j.clbc.2021.12.012 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - January 26, 2022 Category: Cancer & Oncology Authors: Sameena Azhar Laura C Wyatt Vaidehi Jokhakar Shilpa Patel Victoria H Raveis Simona C Kwon Nadia S Islam Source Type: research

Olaparib Use in Patients With Metastatic Breast Cancer Harboring Somatic BRCA1/2 Mutations or Mutations in Non-BRCA1/2, DNA Damage Repair Genes
CONCLUSION: This single institution experience adds to recent larger reports confirming evidence for PARPi therapy in patients with metastatic breast cancer harboring sBRCA1/2 mutations. No activity was observed in patients with either germline or somatic non-BRCA1/2, HRR-mutated cancers.PMID:35074264 | DOI:10.1016/j.clbc.2021.12.007 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - January 25, 2022 Category: Cancer & Oncology Authors: Elaine M Walsh Neha Mangini John Fetting Deborah Armstrong Isaac S Chan Roisin M Connolly Katie Fiallos Jennifer Lehman Raquel Nunes Dana Petry Jeffrey Reynolds Mirat Shah Karen L Smith Kala Visvanathan Josh Lauring Ben H Park Vered Stearns Antonio C Wolf Source Type: research

Short Breastfeeding Duration is Associated With Premature Onset of Female Breast Cancer
Clin Nurs Res. 2022 Jan 25:10547738211069725. doi: 10.1177/10547738211069725. Online ahead of print.ABSTRACTCurrently, there is controversy concerning potential factors that contribute to the development of breast cancer. Our study analyzed the possible association between weight status, cigarette consumption, lactation period, serum estrogen levels, family history of breast cancer, and age at breast cancer diagnosis. We conducted a retrospective study at a University Hospital in Granada (Spain) by consulting the medical records of 524 women aged 19 to 91 years, all of them diagnosed and treated for breast cancer from 2011...
Source: Clinical Breast Cancer - January 25, 2022 Category: Cancer & Oncology Authors: Ángel Fernández-Aparicio Jacqueline Schmidt-RioValle Pedro A Garc ía Emilio Gonz ález-Jiménez Source Type: research

Correction to: A composite oral hygiene score and the risk of oral cancer and its subtypes: a large-scale propensity score-based study
Clin Oral Investig. 2022 Jan 25. doi: 10.1007/s00784-021-04243-6. Online ahead of print.NO ABSTRACTPMID:35076811 | DOI:10.1007/s00784-021-04243-6 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - January 25, 2022 Category: Cancer & Oncology Authors: Qingrong Deng Lingjun Yan Junyu Lin Zhaocheng Zhuang Yihong Hong Chanchan Hu Lisong Lin Lizhen Pan Bin Shi Jing Wang Fengqiong Liu Lin Cai Baochang He Yu Qiu Fa Chen Source Type: research

Prospective Surveillance for Breast Cancer-Related Arm Lymphedema: A Systematic Review and Meta-Analysis
CONCLUSION: The findings suggest that participation in prospective surveillance with early management reduces the risk of chronic BCRaL. Only a minority of patients at high risk of lymphedema because of axillary surgery developed chronic lymphedema. More robust research is needed to determine whether prospective surveillance with early management can reduce the risk of chronic lymphedema, particularly among cancer survivors other than breast cancer.PMID:35077194 | DOI:10.1200/JCO.21.01681 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - January 25, 2022 Category: Cancer & Oncology Authors: Bolette S Rafn Jan Christensen Anders Larsen Kira Bloomquist Source Type: research

Cancer Risks Associated With BRCA1 and BRCA2 Pathogenic Variants
CONCLUSION: In addition to female breast and ovarian cancers, BRCA1 and BRCA2 PVs are associated with increased risks of male breast, pancreatic, stomach, and prostate (only BRCA2 PVs) cancers, but not with the risks of other previously suggested cancers. The estimated age-specific risks will refine cancer risk management in men and women with BRCA1/2 PVs.PMID:35077220 | DOI:10.1200/JCO.21.02112 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - January 25, 2022 Category: Cancer & Oncology Authors: Shuai Li Valentina Silvestri Goska Leslie Timothy R Rebbeck Susan L Neuhausen John L Hopper Henriette Roed Nielsen Andrew Lee Xin Yang Lesley McGuffog Michael T Parsons Irene L Andrulis Norbert Arnold Muriel Belotti Åke Borg Bruno Buecher Saundra S Buys Source Type: research

Health Care Resource Utilization and Costs for Metastatic Breast Cancer Patients Newly Treated with Human Epidermal Growth Factor Receptor 2 (HER2)-Targeted Agents
CONCLUSION: Treatment of HER2-positive mBC is a substantial economic burden. A potential approach to minimizing cost and HCRU is to prevent recurrence.PMID:35067467 | DOI:10.1016/j.clbc.2021.11.013 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - January 24, 2022 Category: Cancer & Oncology Authors: Reshma Mahtani Nina Oestreicher Deepa Lalla Augustina Ogbonnaya Vishal Saundankar Joanne Willey Anna D Coutinho Kelly McCann Source Type: research

Preliminary experiences of PET/MRI in predicting complete response in patients with breast cancer treated with neoadjuvant chemotherapy
In conclusion, PET/MRI is a different diagnostic approach that utilizes a multi-modality system. It demonstrates reasonable diagnostic accuracies of the responses of NAC with reference to hormonal subtypes in breast cancer.PMID:35070299 | PMC:PMC8764658 | DOI:10.3892/mco.2021.2483 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - January 24, 2022 Category: Cancer & Oncology Authors: Chikako Sekine Nachiko Uchiyama Chikashi Watase Takeshi Murata Sho Shiino Kenjiro Jimbo Eriko Iwamoto Shin Takayama Hiroaki Kurihara Kaishi Satomi Masayuki Yoshida Takayuki Kinoshita Akihiko Suto Source Type: research

HER2 changes to positive after neoadjuvant chemotherapy in breast cancer: A case report and literature review
CONCLUSION: Biomarker status should be reassessed after NACT especially in luminal subtypes.PMID:35071526 | PMC:PMC8727267 | DOI:10.12998/wjcc.v10.i1.260 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - January 24, 2022 Category: Cancer & Oncology Authors: Luo Wang Qi Jiang Meng-Ye He Peng Shen Source Type: research

Diagnosis and guidance of treatment of breast cancer cutaneous metastases by multiple needle biopsy: A case report
CONCLUSION: Repeated puncture should be performed for advanced breast cancer with skin metastasis, in order to obtain the pathology and directly determine diagnosis when the disease progresses. The treatment should focus on controlling the systemic metastasis, rather than the local disease.PMID:35071538 | PMC:PMC8727255 | DOI:10.12998/wjcc.v10.i1.345 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - January 24, 2022 Category: Cancer & Oncology Authors: Zhong-Hui Li Fang Wang Ping Zhang Peng Xue Shi-Jie Zhu Source Type: research

Ductal breast carcinoma metastasized to the rectum: A case report and review of the literature
CONCLUSION: Rectal metastasis should be considered when patients with a history of BC present with changed bowel habits.PMID:35071565 | PMC:PMC8717501 | DOI:10.12998/wjcc.v9.i36.11346 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - January 24, 2022 Category: Cancer & Oncology Authors: Bo Ban Kai Zhang Jian-Nan Li Tong-Jun Liu Jian Shi Source Type: research

Impact of Cold Therapy on Paclitaxel-Induced Peripheral Neuropathy and Quality of Life in Patients With Breast Cancer
Clin J Oncol Nurs. 2022 Feb 1;26(1):93-99. doi: 10.1188/22.CJON.93-99.ABSTRACTBACKGROUND: Taxane drugs frequently produce peripheral neuropathy (PN). Cold therapy to hands and feet during chemotherapy has been effective in reducing PN.OBJECTIVES: The purpose was to compare the frequency and severity of PN and quality of life in patients with breast cancer receiving cold therapy to their hands and feet versus standard of care during 12 weekly paclitaxel infusions with a follow-up at 16 weeks.METHODS: Forty-eight female participants were consecutively recruited and randomized to treatment versus control groups. This randomiz...
Source: Clinical Breast Cancer - January 24, 2022 Category: Cancer & Oncology Authors: Mei-Ying Jue Dipti Shah Anne Stiles Tariq Nisar Source Type: research

Patients With Breast Cancer Receiving Chemotherapy: Effects of Multisensory Stimulation Training on Cognitive Impairment
This study observed the interventional effects of multisensory stimulation training on CRCI in patients with breast cancer receiving chemotherapy.METHODS: Eighty patients with breast cancer receiving chemotherapy at a grade A tertiary hospital in Tangshan City, Hebei Province, China, were divided into two intervention groups (audiovisual and multisensory) by random sampling (40 patients per group).FINDINGS: After four intervention cycles, participants' cognitive and executive function scores were higher in the multisensory group than in the audiovisual group. Multisensory stimulation training had stronger effects than audi...
Source: Clinical Breast Cancer - January 24, 2022 Category: Cancer & Oncology Authors: Zeyuan Li Xijun Hao Ping Lei Lizhi Zhou Changxiang Chen Tingting Tan Liming Yue Source Type: research

Health Care Resource Utilization and Costs for Metastatic Breast Cancer Patients Newly Treated with Human Epidermal Growth Factor Receptor 2 (HER2)-Targeted Agents
CONCLUSION: Treatment of HER2-positive mBC is a substantial economic burden. A potential approach to minimizing cost and HCRU is to prevent recurrence.PMID:35067467 | DOI:10.1016/j.clbc.2021.11.013 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - January 24, 2022 Category: Cancer & Oncology Authors: Reshma Mahtani Nina Oestreicher Deepa Lalla Augustina Ogbonnaya Vishal Saundankar Joanne Willey Anna D Coutinho Kelly McCann Source Type: research

Preliminary experiences of PET/MRI in predicting complete response in patients with breast cancer treated with neoadjuvant chemotherapy
In conclusion, PET/MRI is a different diagnostic approach that utilizes a multi-modality system. It demonstrates reasonable diagnostic accuracies of the responses of NAC with reference to hormonal subtypes in breast cancer.PMID:35070299 | PMC:PMC8764658 | DOI:10.3892/mco.2021.2483 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - January 24, 2022 Category: Cancer & Oncology Authors: Chikako Sekine Nachiko Uchiyama Chikashi Watase Takeshi Murata Sho Shiino Kenjiro Jimbo Eriko Iwamoto Shin Takayama Hiroaki Kurihara Kaishi Satomi Masayuki Yoshida Takayuki Kinoshita Akihiko Suto Source Type: research

HER2 changes to positive after neoadjuvant chemotherapy in breast cancer: A case report and literature review
CONCLUSION: Biomarker status should be reassessed after NACT especially in luminal subtypes.PMID:35071526 | PMC:PMC8727267 | DOI:10.12998/wjcc.v10.i1.260 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - January 24, 2022 Category: Cancer & Oncology Authors: Luo Wang Qi Jiang Meng-Ye He Peng Shen Source Type: research

Diagnosis and guidance of treatment of breast cancer cutaneous metastases by multiple needle biopsy: A case report
CONCLUSION: Repeated puncture should be performed for advanced breast cancer with skin metastasis, in order to obtain the pathology and directly determine diagnosis when the disease progresses. The treatment should focus on controlling the systemic metastasis, rather than the local disease.PMID:35071538 | PMC:PMC8727255 | DOI:10.12998/wjcc.v10.i1.345 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - January 24, 2022 Category: Cancer & Oncology Authors: Zhong-Hui Li Fang Wang Ping Zhang Peng Xue Shi-Jie Zhu Source Type: research

Ductal breast carcinoma metastasized to the rectum: A case report and review of the literature
CONCLUSION: Rectal metastasis should be considered when patients with a history of BC present with changed bowel habits.PMID:35071565 | PMC:PMC8717501 | DOI:10.12998/wjcc.v9.i36.11346 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - January 24, 2022 Category: Cancer & Oncology Authors: Bo Ban Kai Zhang Jian-Nan Li Tong-Jun Liu Jian Shi Source Type: research

Impact of Cold Therapy on Paclitaxel-Induced Peripheral Neuropathy and Quality of Life in Patients With Breast Cancer
Clin J Oncol Nurs. 2022 Feb 1;26(1):93-99. doi: 10.1188/22.CJON.93-99.ABSTRACTBACKGROUND: Taxane drugs frequently produce peripheral neuropathy (PN). Cold therapy to hands and feet during chemotherapy has been effective in reducing PN.OBJECTIVES: The purpose was to compare the frequency and severity of PN and quality of life in patients with breast cancer receiving cold therapy to their hands and feet versus standard of care during 12 weekly paclitaxel infusions with a follow-up at 16 weeks.METHODS: Forty-eight female participants were consecutively recruited and randomized to treatment versus control groups. This randomiz...
Source: Clinical Breast Cancer - January 24, 2022 Category: Cancer & Oncology Authors: Mei-Ying Jue Dipti Shah Anne Stiles Tariq Nisar Source Type: research

Patients With Breast Cancer Receiving Chemotherapy: Effects of Multisensory Stimulation Training on Cognitive Impairment
This study observed the interventional effects of multisensory stimulation training on CRCI in patients with breast cancer receiving chemotherapy.METHODS: Eighty patients with breast cancer receiving chemotherapy at a grade A tertiary hospital in Tangshan City, Hebei Province, China, were divided into two intervention groups (audiovisual and multisensory) by random sampling (40 patients per group).FINDINGS: After four intervention cycles, participants' cognitive and executive function scores were higher in the multisensory group than in the audiovisual group. Multisensory stimulation training had stronger effects than audi...
Source: Clinical Breast Cancer - January 24, 2022 Category: Cancer & Oncology Authors: Zeyuan Li Xijun Hao Ping Lei Lizhi Zhou Changxiang Chen Tingting Tan Liming Yue Source Type: research

Insights into the therapeutic potential of histone deacetylase inhibitor/immunotherapy combination regimens in solid tumors
Clin Transl Oncol. 2022 Jan 23. doi: 10.1007/s12094-022-02779-x. Online ahead of print.ABSTRACTSolid tumors including skin, lung, breast, colon, and prostate cancers comprise the most diagnosed cancers worldwide. Treatment of such cancers is still challenging specially in the advanced/metastatic setting. The growing understanding of the tumor microenvironment has revolutionized the cancer therapy paradigms. Targeting programmed death-1 (PD-1)/PD-L1 immune checkpoint has been extensively studied over this decade as a new trend in the management of hard-to-treat cancers by harnessing the power of the immune system to eradica...
Source: Clinical Breast Cancer - January 23, 2022 Category: Cancer & Oncology Authors: Nada K Sedky Alyaa A Hamdan Salma Emad Aya L Allam Mohamed Ali Mai F Tolba Source Type: research

Tau and Stathmin proteins in breast cancer: a potential therapeutic target
Clin Exp Pharmacol Physiol. 2022 Jan 23. doi: 10.1111/1440-1681.13622. Online ahead of print.ABSTRACTBreast cancer is the most common malignant neoplasm among women, responsible for 30% of all malignant tumors, and the second most significant reason of cancer fatality in women. Treatment failure and tumor recurrence are common outcomes of chemotherapy when patients develop multidrug resistance (MDR). New therapeutic methods like molecularly targeted therapeutic interventions need a thorough understanding of malignant tumor's molecular processes. Numerous studies published in the last few years indicate that stathmin and tu...
Source: Clinical Breast Cancer - January 23, 2022 Category: Cancer & Oncology Authors: Hanzhao Yang Source Type: research

Pregnancy after breast cancer in BRCA1/2 mutation carriers
CONCLUSION: According to the existing literature evidence pregnancy after therapy for breast cancer in BRCA carriers is safe for the mother and offspring, but patients' needs, oncofertility counseling and fertility-sparing strategy should be carefully planned before starting the cytotoxic treatment.PMID:35062994 | DOI:10.1186/s13053-022-00209-1 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - January 22, 2022 Category: Cancer & Oncology Authors: Jelena Maksimenko Arv īds Irmejs J ānis Gardovskis Source Type: research

Roles of enhancer RNAs in sex hormone-dependent cancers
CONCLUSION: Abnormal overexpression of eRNAs is mostly oncogenic, leading to cancer progression, and both strands of eRNAs play multiple and complex roles at cis and trans loci in sex hormones mediated pathways, which are tightly associated with sex hormone-dependent tumorigenesis.PMID:35064362 | DOI:10.1007/s00432-021-03886-y (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - January 22, 2022 Category: Cancer & Oncology Authors: Lu Zhang Xiaoxia Ye Jieyi Luo Jiayu Chen Weirang Zheng Minhua Wu Source Type: research

An unusual case of gastric outlet obstruction and melena
Clin J Gastroenterol. 2022 Jan 22. doi: 10.1007/s12328-021-01584-3. Online ahead of print.ABSTRACTStrongyloidiasis is a parasitic infection caused by nematode helminth Strongyloides stercoralis. Severe infection with S. stercoralis is rare and often missed by clinicians which may cause worsen the outcomes. A 57-year-old Hispanic female with past medical history of HIV and breast cancer was transferred from an outside hospital to a tertiary care facility with complaint of persistent abdominal pain and melena. She underwent Esophagogastroduodenoscopy (EGD) twice before her presentation for the same complaints which showed se...
Source: Clinical Breast Cancer - January 22, 2022 Category: Cancer & Oncology Authors: Aysha Aslam Usman Barlas Lindsay J Yassan Maham Lodhi Source Type: research

Perspectives on the role of breast cancer susceptibility gene in breast cancer
Int J Clin Oncol. 2022 Jan 22. doi: 10.1007/s10147-021-02098-1. Online ahead of print.ABSTRACTPURPOSE: Breast cancer susceptibility gene 1/2 can repair damaged DNA through homologous recombination. Besides, the local immune microenvironment of breast cancer is closely linked to the prognosis of patients. But the relationship of breast cancer susceptibility gene 1/2 expression and local immunosuppressive microenvironment in breast cancer is not clear. The aim of this study was to discuss the correlation between them.METHODS: The fresh primary breast tumors and paired normal tissues of 156 cases of breast cancer patients as ...
Source: Clinical Breast Cancer - January 22, 2022 Category: Cancer & Oncology Authors: Nan Wu Lijuan Wei Lijuan Li Fangxuan Li Jinpu Yu Juntian Liu Source Type: research

Pregnancy after breast cancer in BRCA1/2 mutation carriers
CONCLUSION: According to the existing literature evidence pregnancy after therapy for breast cancer in BRCA carriers is safe for the mother and offspring, but patients' needs, oncofertility counseling and fertility-sparing strategy should be carefully planned before starting the cytotoxic treatment.PMID:35062994 | DOI:10.1186/s13053-022-00209-1 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - January 22, 2022 Category: Cancer & Oncology Authors: Jelena Maksimenko Arv īds Irmejs J ānis Gardovskis Source Type: research

Roles of enhancer RNAs in sex hormone-dependent cancers
CONCLUSION: Abnormal overexpression of eRNAs is mostly oncogenic, leading to cancer progression, and both strands of eRNAs play multiple and complex roles at cis and trans loci in sex hormones mediated pathways, which are tightly associated with sex hormone-dependent tumorigenesis.PMID:35064362 | DOI:10.1007/s00432-021-03886-y (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - January 22, 2022 Category: Cancer & Oncology Authors: Lu Zhang Xiaoxia Ye Jieyi Luo Jiayu Chen Weirang Zheng Minhua Wu Source Type: research

An unusual case of gastric outlet obstruction and melena
Clin J Gastroenterol. 2022 Jan 22. doi: 10.1007/s12328-021-01584-3. Online ahead of print.ABSTRACTStrongyloidiasis is a parasitic infection caused by nematode helminth Strongyloides stercoralis. Severe infection with S. stercoralis is rare and often missed by clinicians which may cause worsen the outcomes. A 57-year-old Hispanic female with past medical history of HIV and breast cancer was transferred from an outside hospital to a tertiary care facility with complaint of persistent abdominal pain and melena. She underwent Esophagogastroduodenoscopy (EGD) twice before her presentation for the same complaints which showed se...
Source: Clinical Breast Cancer - January 22, 2022 Category: Cancer & Oncology Authors: Aysha Aslam Usman Barlas Lindsay J Yassan Maham Lodhi Source Type: research

Perspectives on the role of breast cancer susceptibility gene in breast cancer
Int J Clin Oncol. 2022 Jan 22. doi: 10.1007/s10147-021-02098-1. Online ahead of print.ABSTRACTPURPOSE: Breast cancer susceptibility gene 1/2 can repair damaged DNA through homologous recombination. Besides, the local immune microenvironment of breast cancer is closely linked to the prognosis of patients. But the relationship of breast cancer susceptibility gene 1/2 expression and local immunosuppressive microenvironment in breast cancer is not clear. The aim of this study was to discuss the correlation between them.METHODS: The fresh primary breast tumors and paired normal tissues of 156 cases of breast cancer patients as ...
Source: Clinical Breast Cancer - January 22, 2022 Category: Cancer & Oncology Authors: Nan Wu Lijuan Wei Lijuan Li Fangxuan Li Jinpu Yu Juntian Liu Source Type: research

Elevated Baseline Serum PD-L1 Level May Predict Poor Outcomes from Breast Cancer in African-American and Hispanic Women
CONCLUSIONS: PD-L1 serum levels can predict DFS in African American and Hispanic women with breast cancer. Furthermore, a high level of PD-L1 is more likely to be associated with tumor loss PTEN and the activation of Akt or with breast cancer cells expressing CD44high/CD24low. Further validation studies are needed to determine if PD-L1 could serve as a biomarker for patient selection for anti-PD-L1 therapy and assess treatment outcomes.PMID:35053979 | DOI:10.3390/jcm11020283 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - January 21, 2022 Category: Cancer & Oncology Authors: Yanyuan Wu Pranabananda Dutta Sheilah Clayton Amaya McCloud Jaydutt V Vadgama Source Type: research

A Systematic Review of Nutritional Lab Correlates with Chemotherapy Induced Peripheral Neuropathy
J Clin Med. 2022 Jan 12;11(2):355. doi: 10.3390/jcm11020355.ABSTRACTChemotherapy induced peripheral neuropathy (CIPN) is a dose-limiting side effect of chemotherapy for which no prevention or cure exists. Cancer and cancer treatments can adversely affect nutritional status. Nutrition may play a role in development of CIPN, yet the relationship between nutrition and CIPN is not well understood. Common laboratory values measuring various aspects of nutrition (hemoglobin/hematocrit, vitamin B12, calcium, and magnesium) may be associated with CIPN. The aim of this systematic review is to evaluate the empirical evidence surroun...
Source: Clinical Breast Cancer - January 21, 2022 Category: Cancer & Oncology Authors: Cindy Tofthagen Mary Tanay Adam Perlman Jason Starr Pooja Advani Katharine Sheffield Tara Brigham Source Type: research

Prognostic Value of Galectin Expression in Patients with Breast Cancer: Systematic Review and Meta-Analysis
In conclusion, galectin-3 correlates with OS in breast cancer when cellular localization is considered while galectin-7 correlates with DFS/PFS/DSS. The cellular localization of galectins should be as fundamental aspect to be determined in future studies.PMID:35058144 | DOI:10.1016/j.clbc.2021.12.011 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - January 21, 2022 Category: Cancer & Oncology Authors: Juan Carlos Ramos-Mart ínez Gerardo Altamirano-G ómez Ivan Ramos-Mart ínez Jorge Valencia Luis Hern ández-Zimbrón Jes ús Hernández-Juárez Patricia Echeverr ía-Vásquez Leticia L Hern ández-González Eduardo P érez-Campos Laura P érez-Campos Ma Source Type: research

Care pathway of women with interval breast cancer in 2016, based on medico-administrative data
CONCLUSION: The care pathways of women with IC are intermediate with respect to those of the OS or PSCS group.Cases of IC probably include several cancer prognosis profiles.PMID:35058145 | DOI:10.1016/j.clbc.2021.12.003 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - January 21, 2022 Category: Cancer & Oncology Authors: Christine Le Bihan-Benjamin Camille Bertrand Florence Molini é Agn ès Rogel Jean-Baptiste M éric Norbert Ifrah Philippe-Jean Bousquet Source Type: research

RBE-weighted dose and its impact on the risk of acute coronary event for breast cancer patients treated with intensity modulated proton therapy
CONCLUSION: All three RBE models predicted a higher biological dose compared to the clinical standard dose assuming a constant RBE of 1.1. An underestimation of the biological dose results in underestimation of the ACE risk. Analyzing the voxel-by-voxel biological dose and the LET map alongside clinical outcomes is warranted in the development of a more accurate normal-tissue complication probability model.PMID:35060317 | DOI:10.1002/acm2.13527 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - January 21, 2022 Category: Cancer & Oncology Authors: Chunbo Liu Julie A Bradley Dandan Zheng Raymond B Mailhot Vega Chris J Beltran Nancy Mendenhall Xiaoying Liang Source Type: research

Physical Activity Patterns and Cognitive Function in Patients With Breast Cancer
J Clin Oncol. 2022 Jan 21:JCO2102073. doi: 10.1200/JCO.21.02073. Online ahead of print.NO ABSTRACTPMID:35061503 | DOI:10.1200/JCO.21.02073 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - January 21, 2022 Category: Cancer & Oncology Authors: Shipeng Ning Kun Qiao Linghui Pan Source Type: research

Development and Validation of a Predictive Model of Severe Fatigue After Breast Cancer Diagnosis: Toward a Personalized Framework in Survivorship Care
CONCLUSION: We propose a predictive model to assess fatigue among breast cancer survivors, within a personalized survivorship care framework. This may help clinicians to provide early management interventions or to correct modifiable risk factors and offer more tailored monitoring and education to patients at risk of severe post-treatment fatigue.PMID:35061509 | DOI:10.1200/JCO.21.01252 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - January 21, 2022 Category: Cancer & Oncology Authors: Antonio Di Meglio Julie Havas Davide Soldato Daniele Presti Elise Martin Barbara Pistilli Gwenn Menvielle Agnes Dumas Cecile Charles Sibille Everhard Anne-Laure Martin Charles Coutant Carole Tarpin Laurence Vanlemmens Christelle Levy Olivier Rigal Suzette Source Type: research

Outcome of Patients With an Ultralow-Risk 70-Gene Signature in the MINDACT Trial
CONCLUSION: Patients with an ultralow-risk 70-gene signature have the best prognosis, distinctive from low risk, with 8-year BCSS above 99%, and very few patients developed distant metastases with an 8-year DMFI rate of 97%. These patients could be candidates for further de-escalation of treatment, to avoid overtreatment and the risk of side effects.PMID:35061525 | DOI:10.1200/JCO.21.02019 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - January 21, 2022 Category: Cancer & Oncology Authors: Josephine M N Lopes Cardozo Caroline A Drukker Emiel J T Rutgers Marjanka K Schmidt Annuska M Glas Anke Witteveen Fatima Cardoso Martine Piccart Laura J Esserman Coralie Poncet Laura J van 't Veer Source Type: research

Elevated Baseline Serum PD-L1 Level May Predict Poor Outcomes from Breast Cancer in African-American and Hispanic Women
CONCLUSIONS: PD-L1 serum levels can predict DFS in African American and Hispanic women with breast cancer. Furthermore, a high level of PD-L1 is more likely to be associated with tumor loss PTEN and the activation of Akt or with breast cancer cells expressing CD44high/CD24low. Further validation studies are needed to determine if PD-L1 could serve as a biomarker for patient selection for anti-PD-L1 therapy and assess treatment outcomes.PMID:35053979 | DOI:10.3390/jcm11020283 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - January 21, 2022 Category: Cancer & Oncology Authors: Yanyuan Wu Pranabananda Dutta Sheilah Clayton Amaya McCloud Jaydutt V Vadgama Source Type: research

A Systematic Review of Nutritional Lab Correlates with Chemotherapy Induced Peripheral Neuropathy
J Clin Med. 2022 Jan 12;11(2):355. doi: 10.3390/jcm11020355.ABSTRACTChemotherapy induced peripheral neuropathy (CIPN) is a dose-limiting side effect of chemotherapy for which no prevention or cure exists. Cancer and cancer treatments can adversely affect nutritional status. Nutrition may play a role in development of CIPN, yet the relationship between nutrition and CIPN is not well understood. Common laboratory values measuring various aspects of nutrition (hemoglobin/hematocrit, vitamin B12, calcium, and magnesium) may be associated with CIPN. The aim of this systematic review is to evaluate the empirical evidence surroun...
Source: Clinical Breast Cancer - January 21, 2022 Category: Cancer & Oncology Authors: Cindy Tofthagen Mary Tanay Adam Perlman Jason Starr Pooja Advani Katharine Sheffield Tara Brigham Source Type: research

Prognostic Value of Galectin Expression in Patients with Breast Cancer: Systematic Review and Meta-Analysis
In conclusion, galectin-3 correlates with OS in breast cancer when cellular localization is considered while galectin-7 correlates with DFS/PFS/DSS. The cellular localization of galectins should be as fundamental aspect to be determined in future studies.PMID:35058144 | DOI:10.1016/j.clbc.2021.12.011 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - January 21, 2022 Category: Cancer & Oncology Authors: Juan Carlos Ramos-Mart ínez Gerardo Altamirano-G ómez Ivan Ramos-Mart ínez Jorge Valencia Luis Hern ández-Zimbrón Jes ús Hernández-Juárez Patricia Echeverr ía-Vásquez Leticia L Hern ández-González Eduardo P érez-Campos Laura P érez-Campos Ma Source Type: research

Care pathway of women with interval breast cancer in 2016, based on medico-administrative data
CONCLUSION: The care pathways of women with IC are intermediate with respect to those of the OS or PSCS group.Cases of IC probably include several cancer prognosis profiles.PMID:35058145 | DOI:10.1016/j.clbc.2021.12.003 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - January 21, 2022 Category: Cancer & Oncology Authors: Christine Le Bihan-Benjamin Camille Bertrand Florence Molini é Agn ès Rogel Jean-Baptiste M éric Norbert Ifrah Philippe-Jean Bousquet Source Type: research

RBE-weighted dose and its impact on the risk of acute coronary event for breast cancer patients treated with intensity modulated proton therapy
CONCLUSION: All three RBE models predicted a higher biological dose compared to the clinical standard dose assuming a constant RBE of 1.1. An underestimation of the biological dose results in underestimation of the ACE risk. Analyzing the voxel-by-voxel biological dose and the LET map alongside clinical outcomes is warranted in the development of a more accurate normal-tissue complication probability model.PMID:35060317 | DOI:10.1002/acm2.13527 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - January 21, 2022 Category: Cancer & Oncology Authors: Chunbo Liu Julie A Bradley Dandan Zheng Raymond B Mailhot Vega Chris J Beltran Nancy Mendenhall Xiaoying Liang Source Type: research

Physical Activity Patterns and Cognitive Function in Patients With Breast Cancer
J Clin Oncol. 2022 Jan 21:JCO2102073. doi: 10.1200/JCO.21.02073. Online ahead of print.NO ABSTRACTPMID:35061503 | DOI:10.1200/JCO.21.02073 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - January 21, 2022 Category: Cancer & Oncology Authors: Shipeng Ning Kun Qiao Linghui Pan Source Type: research