Recurrent Brain Metastasis of Triple Negative Breast Cancer With High Uptake in 68Ga-PSMA-11 PET/CT.
We present a 47-year-old woman with TNBC having recurrent brain metastasis with avid PSMA receptor activity versus low FDG uptake. PMID: 33065618 [PubMed - indexed for MEDLINE] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Arslan E, Ergül N, Karagöz Y, Gedik AA, Çermik TF Tags: Clin Nucl Med Source Type: research

Relationship between adverse events associated with lenvatinib treatment for thyroid cancer and patient prognosis.
Abstract Tyrosine kinase inhibitors (TKIs) were first approved for treating radioactive iodine-refractory differentiated thyroid cancer (DTC) and anaplastic thyroid cancer (ATC) 5 years ago. Among them, lenvatinib has a high response rate and has become the first-line drug for treating thyroid cancer. Although it has a high response rate, it is also characterized by a high frequency of adverse events (AEs). AEs previously reported in a phase II study occurred after the practical application of TKI therapy. However, the type and frequency of AEs that occurred were significantly different. The present study investig...
Source: Clinical Breast Cancer - January 10, 2021 Category: Cancer & Oncology Authors: Iwasaki H, Toda S, Murayama D, Kato S, Matsui A Tags: Mol Clin Oncol Source Type: research

Multiple microRNAs as biomarkers for early breast cancer diagnosis.
Abstract MicroRNA (miRNA or miR) is stably present in plasma. It has been reported that miRNA could be used for detecting cancer. Circulating miRNAs are being increasingly recognized as powerful biomarkers in a number of different pathologies, including in breast cancer. The aim of the current study was to establish and validate miRNA sets that are useful for the early diagnosis of breast cancer. Specifically, the current study intended to determine whether miRNA biomarkers were tumor-specific and to statistically verify whether circulating miRNA analysis could be used for breast cancer diagnosis. In the present s...
Source: Clinical Breast Cancer - January 10, 2021 Category: Cancer & Oncology Authors: Jang JY, Kim YS, Kang KN, Kim KH, Park YJ, Kim CW Tags: Mol Clin Oncol Source Type: research

Surgical indications and clinical management of benign and malignant follicular thyroid tumors: An algorithmic-based approach.
Abstract The present study retrospectively reviewed the treatment courses and results of patients with follicular thyroid tumors, including carcinomas. In the 5 year study period from April 2015 to March 2020, 797 patients with differentiated thyroid carcinoma and 128 patients with follicular tumors (FTs) received surgery or treatment for distant metastases and recurrence at the Kanagawa Cancer Center (Japan). Of these patients, 73 that were diagnosed with follicular thyroid carcinoma (FTC) were included in the present study. An algorithm used for the application of treatment strategies was assessed. The aim of th...
Source: Clinical Breast Cancer - January 10, 2021 Category: Cancer & Oncology Authors: Iwasaki H, Toda S, Murayama D, Kato S, Matsui A Tags: Mol Clin Oncol Source Type: research

Association between serum soluble Toll-like receptor 2 and 4 and the risk of breast cancer.
In conclusion, sTLR2 and sTLR4 may be potential biomarkers of breast cancer susceptibility. PMID: 33414918 [PubMed] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - January 10, 2021 Category: Cancer & Oncology Authors: El-Kharashy G, Gowily A, Okda T, Houssen M Tags: Mol Clin Oncol Source Type: research

Bilateral Silicone Granulomas Mimicking Breast Cancer Recurrence on 18F-FDG PET/CT.
We report the case of a 45-year-old woman with a history of right breast reconstruction with silicone implant for breast cancer. An 18F-FDG PET/CT performed several years later revealed the presence of 18F-FDG-avid nodules at the periphery of the silicone implant, in the right internal mammary chain, and in the contralateral breast. Needle core biopsies were positive for bilateral silicone granulomas, without any sign of malignancy. This case displays intense 18F-FDG uptake in silicone granulomas affecting the contralateral breast after implant reconstruction. PMID: 33234930 [PubMed - indexed for MEDLINE] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - January 9, 2021 Category: Cancer & Oncology Authors: Fernandes Vieira V, Dubruc E, Raffoul W, Prior JO, Meyer M Tags: Clin Nucl Med Source Type: research

A rare case of isolated splenic sarcoidosis: A case report and literature review.
Abstract Sarcoidosis is a multisystemic granulomatous disease. It is rarely isolated in the spleen. The present report describes a case of isolated splenic sarcoidosis that was diagnosed histologically following laparoscopic splenectomy. A 76-year-old woman, who underwent radical nephroureterectomy 7 years earlier for left renal pelvic cancer and mastectomy 6 years earlier for left breast cancer in another facility, was referred to our hospital for assessment of splenic tumors that were identified during a follow-up examination. The computed tomography scans revealed multiple nodules in the spleen, which had incre...
Source: Clinical Breast Cancer - December 20, 2020 Category: Cancer & Oncology Authors: Kobayashi K, Einama T, Fujinuma I, Tsunenari T, Miyata Y, Iwasaki T, Asakuma J, Soga S, Shinmoto H, Tsujimoto H, Hase K, Ueno H, Kishi Y Tags: Mol Clin Oncol Source Type: research

CDK 4/6 inhibitors combined with radiotherapy: A review of literature.
te; N Abstract Cyclin-dependent kinase 4 and 6 inhibitors (CDK4/6i) namely palbociclib, ribociclib and abemaciclib were granted approval by the European Medicines Agency (EMA) between 2017 and 2018. They are currently prescribed in combination with hormone therapy to treat hormone receptor positive, HER2 negative metastatic or locally advanced breast cancer. Their combination with radiotherapy raises safety concerns as preclinical data enlightened their possible synergistic effect. Moreover, data about toxicity when combining CDK4/6i with radiotherapy are scarce. This review of literature focused on the use of CDK...
Source: Clinical Breast Cancer - December 17, 2020 Category: Cancer & Oncology Authors: Bosacki C, Bouleftour W, Sotton S, Vallard A, Daguenet E, Ouaz H, Cojoracu I, Moslemi D, Molekzadehmoghani M, Magné N Tags: Clin Transl Radiat Oncol Source Type: research

Role of diffusion-weighted imaging in prediction of nipple-areolar complex invasion by breast cancer.
CONCLUSION: DWI can predict malignant NAC invasion in patients with breast cancer. PMID: 32652457 [PubMed - indexed for MEDLINE] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - December 16, 2020 Category: Cancer & Oncology Authors: Razek AAKA, El-Adalany MA, El-Metwally D Tags: Clin Imaging Source Type: research

Accuracy in tumor size measurements: Comparison of digital mammography, digital breast tomosynthesis and synthetic mammography.
Teke F Abstract PURPOSE: The aim of this study was to assess the accuracy of digital mammography (DM), digital breast tomosynthesis (DBT) and synthetic mammography (SM) in tumor size measurements compared with histological tumor sizes. MATERIALS AND METHODS: 71 breast cancer patients who underwent DM and DBT acquisitions simultaneously were included in this study. One radiologist with 8 years of experience in breast imaging measured tumor sizes independently in three separate sessions which include DM, DBT and SM images, respectively. The correlations between the measured tumor sizes on each imaging techni...
Source: Clinical Breast Cancer - December 16, 2020 Category: Cancer & Oncology Authors: Şendur HN, Cerit MN, Gültekin S, Cindil E, Avdan Aslan A, Erdal ZS, Gültekin Iİ, Teke F Tags: Clin Imaging Source Type: research

Contrast-enhanced mammography: past, present, and future.
This article will provide a comprehensive overview on the past, present, and future of CEM, including its evolving role in the diagnostic and screening settings. PMID: 33032103 [PubMed - indexed for MEDLINE] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - December 16, 2020 Category: Cancer & Oncology Authors: Sogani J, Mango VL, Keating D, Sung JS, Jochelson MS Tags: Clin Imaging Source Type: research

Is specimen radiography still necessary in patients with non-palpable breast cancer undergoing breast-conserving surgery using radioactive I-125 seed localization?
CONCLUSION: SR has a moderate diagnostic performance for margin involvement using RSL. A more accurate intraoperative margin assessment tool is warranted. PMID: 33045475 [PubMed - indexed for MEDLINE] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - December 16, 2020 Category: Cancer & Oncology Authors: van Riet YE, Schipper RJ, van Merrienboer F, Orsini RG, Bloemen JG, Jansen FH, Nieuwenhuijzen GAP Tags: Clin Imaging Source Type: research

Chondrolipoma of the finger in a child: A case study.
Abstract Chondrolipoma is, based on the limited case reports available, an extremely rare histological variant of lipoma with the proliferation of mature adipocytes containing an area of true hyaline cartilage. Chondrolipoma is characterized by adult onset and is often identified in the breast, pharynx and tongue. The current study presents a case of chondrolipoma of the finger in an 11 year-old girl. Physical examination indicated a well-defined elastic soft mass, measuring 2.5x2 cm, on the dorsal aspect of the proximal phalanx of the left middle finger. Magnetic resonance imaging (MRI) revealed a well-circumscri...
Source: Clinical Breast Cancer - November 27, 2020 Category: Cancer & Oncology Authors: Mitani K, Kawamoto T, Hara H, Fukase N, Kawakami Y, Morishita M, Takemori T, Fujiwara S, Kitayama K, Yahiro S, Miyamoto T, Komatsu M, Jimbo N, Kuroda R, Akisue T Tags: Mol Clin Oncol Source Type: research

Surgical Management of Breast Cancer Liver Metastasis.
This article reviews data related to hepatic resection and ablative therapies of BCLM, as well as long-term outcomes of women treated with these approaches. PMID: 33220807 [PubMed - in process] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - November 24, 2020 Category: Cancer & Oncology Authors: Rahnemai-Azar AA, Selby LV, Lustberg MB, Pawlik TM Tags: Surg Oncol Clin N Am Source Type: research

Breast Implant-Associated Anaplastic Large Cell Lymphoma: Defining Future Research Priorities.
Abstract Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is an emerging cancer of the immune system that is exclusively associated with textured-surface breast implants. This clinical review provides an update on the diagnosis and management of BIA-ALCL with an emphasis on major advances. The epidemiology and pathophysiology of the disease are also reviewed, focusing on current paradigm shifts and highlighting current controversies related to disease classification and risk mitigation. Finally, the authors conclude by discussing medicolegal and ethical issues surrounding BIA-ALCL while establis...
Source: Clinical Breast Cancer - November 24, 2020 Category: Cancer & Oncology Authors: DeCoster RC, Lynch EB, Bonaroti AR, Miranda RN, Hunt KK, Clemens MW Tags: Clin Plast Surg Source Type: research

The Impact of the COVID-19 Pandemic on Breast Imaging.
This article summarizes the effect of the global pandemic-and efforts to curtail its spread-on both breast cancer care and on breast imaging practices including effects on patients, clinical workflow, education, and research." PMID: 33222992 [PubMed - in process] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - November 24, 2020 Category: Cancer & Oncology Authors: Freer PE Tags: Radiol Clin North Am Source Type: research

Contrast-Enhanced Mammography Implementation, Performance, and Use for Supplemental Breast Cancer Screening.
Abstract Contrast-enhanced mammography (CEM) is an emerging breast imaging technology that provides recombined contrast-enhanced images of the breast in addition to low-energy images analogous to a 2-dimensional full-field digital mammogram. Because most breast imaging centers do not use CEM at this time, a detailed overview of CEM implementation and performance is presented. Thereafter, the potential use of CEM for supplemental screening is discussed in detail, given the importance of this topic for the future of the CEM community. Diagnostic performance, safety, and cost considerations of CEM for dense breast ti...
Source: Clinical Breast Cancer - November 24, 2020 Category: Cancer & Oncology Authors: Covington MF Tags: Radiol Clin North Am Source Type: research

Is It the Era for Personalized Screening?
This article reviews the current recommendations for breast cancer risk assessment and breast cancer screening in average-risk and higher-than-average-risk women. Also discussed are new developments and future perspectives for personalized breast cancer screening. PMID: 33222994 [PubMed - in process] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - November 24, 2020 Category: Cancer & Oncology Authors: Saccarelli CR, Bitencourt AGV, Morris EA Tags: Radiol Clin North Am Source Type: research

Breast Radiology Advocacy: Responding to the Call-to-Action.
Abstract In an increasingly competitive and passionate health care environment, radiology advocacy is imperative, now more than ever. Arguably, it is particularly more crucial in the world of breast cancer, as we as a breast cancer community are tirelessly assembling to advocate for our patients on a variety of levels, whether it is including but not limited to, breast cancer screening, diagnosis, and treatment, access-to-care, education, or research funding. As breast radiologists, it is no longer simply enough to clock in our normal work hours; we must ALL make a concerted effort to vociferously advocate for our...
Source: Clinical Breast Cancer - November 24, 2020 Category: Cancer & Oncology Authors: Patel AK Tags: Radiol Clin North Am Source Type: research

Applications of Artificial Intelligence in Breast Imaging.
Abstract Artificial intelligence (AI) technology shows promise in breast imaging to improve both interpretive and noninterpretive tasks. AI-based screening triage may help identify normal examinations and AI-based computer-aided detection (AI-CAD) may increase cancer detection and reduce false positives. Risk assessment, quality assurance, and other workflow tasks may also be streamlined. AI adoption will depend on robust evidence of improved quality, increased efficiency, and cost-effectiveness. Reliance on AI will likely proceed through stages and will involve careful attention to its limitations to prevent over...
Source: Clinical Breast Cancer - November 24, 2020 Category: Cancer & Oncology Authors: Morgan MB, Mates JL Tags: Radiol Clin North Am Source Type: research

Overdiagnosis and Risks of Breast Cancer Screening.
Abstract Since its widespread introduction 30 years ago, screening mammography has contributed to substantial reduction in breast cancer-associated mortality, ranging from 15% to 50% in observational trials. It is currently the best examination available for the early diagnosis of breast cancer, when survival and treatment options are most favorable. However, like all medical tests and procedures, screening mammography has associated risks, including overdiagnosis and overtreatment, false-positive examinations, false-positive biopsies, and radiation exposure. Women should be aware of the benefits and risks of scre...
Source: Clinical Breast Cancer - November 24, 2020 Category: Cancer & Oncology Authors: Neal CH, Helvie MA Tags: Radiol Clin North Am Source Type: research

Management of High-Risk Breast Lesions.
This article reviews histologic features and clinical presentation of each of the HRLs, current evidence with regard to management, and guidelines from the American Society of Breast Surgeons and National Comprehensive Cancer Network. In addition, imaging surveillance and risk-reduction strategies for women with HRLs are discussed. PMID: 33222998 [PubMed - in process] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - November 24, 2020 Category: Cancer & Oncology Authors: Bahl M Tags: Radiol Clin North Am Source Type: research

Understanding the Mammography Audit.
This article defines audit terms and describes how to use collected and derived data to perform a mammography audit. Accepted benchmarks are discussed as well as their applicability to radiologists and breast imaging practices in the United States. Special considerations regarding volumes and radiologist characteristics are explored, because these factors may affect audit results. PMID: 33222999 [PubMed - in process] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - November 24, 2020 Category: Cancer & Oncology Authors: Funaro K, Ataya D, Niell B Tags: Radiol Clin North Am Source Type: research

Breast Magnetic Resonance Imaging Audit: Pitfalls, Challenges, and Future Considerations.
This article provides a framework for performing a breast MR imaging audit in clinical practice, incorporating ACR BI-RADS guidance and more recently published data, clarifies common pitfalls, and discusses audit challenges related to evolving clinical practice. PMID: 33223000 [PubMed - in process] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - November 24, 2020 Category: Cancer & Oncology Authors: Lam DL, Lee JM Tags: Radiol Clin North Am Source Type: research

Supplemental Screening for Patients at Intermediate and High Risk for Breast Cancer.
Abstract The sensitivity of mammography is more limited in patients with dense breasts and some patients at higher risk for breast cancer. Patients with intermediate or high risk for breast cancer may begin screening earlier and benefit from supplemental screening techniques beyond standard 2-dimensional mammography. A patient's individual risk factors for developing breast cancer, their breast density, and the evidence supporting specific modalities for a given clinical scenario help to determine the need for supplemental screening and the modality chosen. Additional factors include the availability of supplement...
Source: Clinical Breast Cancer - November 24, 2020 Category: Cancer & Oncology Authors: Wang L, Strigel RM Tags: Radiol Clin North Am Source Type: research

Magnetic Resonance Imaging in Screening of Breast Cancer.
Abstract Magnetic Resonance (MR) imaging is the most sensitive modality for breast cancer detection but is currently limited to screening women at high risk due to limited specificity and test accessibility. However, specificity of MR imaging improves with successive rounds of screening, and abbreviated approaches have the potential to increase access and decrease cost. There is growing evidence to support supplemental MR imaging in moderate-risk women, and current guidelines continue to evolve. Functional imaging has the potential to maximize survival benefit of screening. Leveraging MR imaging as a possible prim...
Source: Clinical Breast Cancer - November 24, 2020 Category: Cancer & Oncology Authors: Gao Y, Reig B, Heacock L, Bennett DL, Heller SL, Moy L Tags: Radiol Clin North Am Source Type: research

Abbreviated MR Imaging for Breast Cancer.
Abstract Breast MR imaging is the most sensitive imaging method for the detection of breast cancer and detects more aggressive malignancies than mammography and ultrasound examination. Despite these advantages, breast MR imaging has low use rates for breast cancer screening. Abbreviated breast MR imaging, in which a limited number of breast imaging sequences are obtained, has been proposed as a way to solve cost and patient tolerance issues while preserving the high cancer detection rate of breast MR imaging. This review discusses abbreviated breast MR imaging, including protocols, multicenter clinical trial resul...
Source: Clinical Breast Cancer - November 24, 2020 Category: Cancer & Oncology Authors: Heacock L, Lewin AA, Toth HK, Moy L, Reig B Tags: Radiol Clin North Am Source Type: research

The Frailty Syndrome: A Critical Issue in Geriatric Oncology.
Abstract The number of older adults with cancer is growing in the United States, and there is a relative paucity of data relating the presence of frailty with its outcomes of interest. The authors present the surgical oncology, radiation oncology, and medical oncology literature with respect to the presence of frailty in older adults with cancer. More research is needed to understand how the presence of frailty should be used by surgical, radiation, and medical oncologists to guide patient counseling and treatment planning. PMID: 33190767 [PubMed - in process] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - November 17, 2020 Category: Cancer & Oncology Authors: Minami CA, Cooper Z Tags: Crit Care Clin Source Type: research

A Novel Proteomic Method Reveals NLS Tagging of T-DM1 Contravenes Classical Nuclear Transport in a Model of HER2-Positive Breast Cancer.
This study results in an effective target cell-specific NLS therapeutic and a general approach to guide future NLS-based development initiatives. PMID: 33024794 [PubMed] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - October 9, 2020 Category: Cancer & Oncology Authors: Lacasse V, Beaudoin S, Jean S, Leyton JV Tags: Mol Ther Methods Clin Dev Source Type: research

HER2-positive breast cancer that resists therapeutic drugs and ionizing radiation releases sphingomyelin-based molecules to circulating blood serum.
Abstract Breast cancer is the second most common cancer in the world based on incidence, reaching more than 2 million new cases in 2018, while continuing to increase. Invasive ductal carcinoma is the most common type of this cancer, making up approximately 70-80% of all breast cancer diagnoses. In particular, the type of breast cancer overexpressing human epidermal growth factor receptor 2 (HER2) has potential of strong proliferation, migration and invasion and early treatment is necessary. The authors identified and studied a single patient displaying complete therapeutic resistance to monoclonal anti-HER2 antibo...
Source: Clinical Breast Cancer - October 3, 2020 Category: Cancer & Oncology Authors: Monzen S, Tatara Y, Mariya Y, Chiba M, Wojcik A, Lundholm L Tags: Mol Clin Oncol Source Type: research

Asymptomatic solitary metastasis to the stomach from breast cancer: A case report.
Abstract Distant metastases from breast cancer are frequently found in bones, lungs and the liver. Metastasis to the stomach is rare, and its clinical presentation remains unclear. The present report describes a case of isolated gastric metastasis from breast cancer identified by contrast-enhanced computed tomography (CT). A 45-year-old female patient underwent right mastectomy and axillary lymph node dissection after preoperative chemotherapy for right invasive lobular breast carcinoma T4bN2M0, stage IIIB. Postoperative radiotherapy and endocrine therapy with tamoxifen for 5 years were performed. CT for postopera...
Source: Clinical Breast Cancer - October 3, 2020 Category: Cancer & Oncology Authors: Kaneko Y, Koi Y, Kajitani K, Ohara M, Daimaru Y Tags: Mol Clin Oncol Source Type: research

Lifting the fog of confusion about breast cancer screening guidelines: Surprise - it's about the money!
Abstract Large amounts of misinformation denigrating the benefits of breast cancer screening have been published over the past 50 years and continue to be published. Each effort to reduce breast cancer screening has been refuted, scientifically, but the efforts continue. The motivation has been unclear until the recent guidelines issued by the American Society of Breast Surgeons who support annual screening starting at the age of 40 contrasted with the American College of Physicians who advocated delaying screening until the age of 50 and then biennially. An analysis of the facts can only lead to the conclusi...
Source: Clinical Breast Cancer - September 25, 2020 Category: Cancer & Oncology Authors: Kopans DB Tags: Clin Imaging Source Type: research

Massage therapy in the breast imaging department: repurposing an ancient anxiety reducing method.
Abstract BACKGROUND: Massage therapy's ability to mitigate breast imaging associated anxiety has not been previously studied. Anxiety is, however, often cited as a harm of screening mammography with few options offered to diminish anxiety other than not screening. Reducing anxiety may improve compliance, and reduce breast cancer mortality and morbidity. A complimentary massage therapy program evaluated patient acceptance, anxiety perception and perceived value of massage. METHODS: Over 10 weeks, verbal agreement was obtained from 113 breast imaging patients who desired a hand or shoulder/neck massage. Li...
Source: Clinical Breast Cancer - September 25, 2020 Category: Cancer & Oncology Authors: Ashton JC, Bousquet D, Fevrier E, Yip R, Chaudhry S, Port E, Margolies LR Tags: Clin Imaging Source Type: research

Performance of preoperative breast MRI based on breast cancer molecular subtype.
CONCLUSION: Breast cancer molecular subtype did not influence biopsy recommendations, positive predictive values, or surgical approaches. Only true positive biopsies increased the mastectomy rate. PMID: 32619774 [PubMed - indexed for MEDLINE] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - September 25, 2020 Category: Cancer & Oncology Authors: Devalapalli A, Thomas S, Mazurowski MA, Saha A, Grimm LJ Tags: Clin Imaging Source Type: research

Lifetime attributable risk of cancer incidence and mortality in routine digital radiology procedures.
CONCLUSION: The lifetime attributable risk of cancer incidence and mortality due to radiation exposure is not trivial. Therefore efforts should be made to reduce patient doses while maintaining image quality. PMID: 32871427 [PubMed - indexed for MEDLINE] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - September 25, 2020 Category: Cancer & Oncology Authors: Zangeneh M, Deevband MR, Mohsenzadeh B Tags: Clin Imaging Source Type: research

The role of long noncoding RNA SNHG7 in human cancers (Review).
Abstract Long non-coding RNAs (lncRNAs) have been demonstrated to serve important roles in a variety of human tumor types. The lncRNA small nucleolar RNA host gene 7 (SNHG7) is associated with a variety of cancer types, such as esophageal cancer, breast cancer and gastric neoplasia. Based on previous studies that examined SNHG7 expression in tumors, it has become clear that SNHG7 modulates tumorigenesis and cancer progression by acting as a competing endogenous RNA. SNHG7 can sponge tumor-suppressive microRNAs and regulate downstream signaling pathways. In addition, overexpression of SNHG7 is associated with the c...
Source: Clinical Breast Cancer - September 4, 2020 Category: Cancer & Oncology Authors: Bian Z, Ji W, Xu B, Huang W, Jiao J, Shao J, Zhang X Tags: Mol Clin Oncol Source Type: research

Risk factors of breast intraductal lesions in patients without pathological nipple discharge.
Abstract The majority of breast cancer arises from the ductal epithelium. It is crucial in the diagnosis and treatment of breast cancer by detecting intraductal lesions at an early stage. The typical clinical characteristic of intraductal lesions is pathological nipple discharge (PND), although many patients with intraductal lesions do not exhibit PND. It is a serious challenge for clinicians to detect patients with intraductal lesions without PND at an early stage. The aim of the present study was to investigate the risk factors associated with intraductal lesions in patients without PND. This retrospective datab...
Source: Clinical Breast Cancer - August 26, 2020 Category: Cancer & Oncology Authors: Shen L, Ye Y, Liu X, Li W, Wei J, Ke Z, Yang S, Yang Z Tags: Mol Clin Oncol Source Type: research

Ground-glass opacity-featured lung adenocarcinoma has no response to chemotherapy.
CONCLUSION: GGO-featured lung adenocarcinoma has no response to chemotherapy. For these patients, chemotherapy should not be a treatment option. PMID: 32356178 [PubMed - indexed for MEDLINE] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - August 13, 2020 Category: Cancer & Oncology Authors: Zhang Y, Deng C, Ma X, Gao Z, Wang S, Zheng Q, Xia G, Wen Z, Han H, Fu F, Liu Q, Hu H, Li Y, Wong KK, Chen H Tags: J Cancer Res Clin Oncol Source Type: research

Historical retrospective of the SRC oncogene and new perspectives (Review).
Abstract Since its first discovery as part of the Rous sarcoma virus (RSV) genome, the c-SRC (SRC) proto-oncogene has been proved a key regulator of cancer development and progression, and thus it has been highlighted as an attractive target for anti-cancer therapeutic strategies. Though the exact mechanisms of its action are still not fully understood, SRC protein mediates crucial normal cell functions, such as cell development, proliferation and survival, and its dysregulation is considered as an oncogenic signature and a driving force for cancer initiation. In the present review, we present a flashback to the h...
Source: Clinical Breast Cancer - August 13, 2020 Category: Cancer & Oncology Authors: Simatou A, Simatos G, Goulielmaki M, Spandidos DA, Baliou S, Zoumpourlis V Tags: Mol Clin Oncol Source Type: research

Molecular analysis of circulating tumor DNA from breast cancer patients before and after surgery and following adjuvant chemotherapy.
Abstract The primary aim of the present study is to provide a complex molecular profile of tumors using liquid biopsy and to monitor profile changes over time in association with surgery and administered adjuvant therapy. Our secondary aim was to compare the liquid biopsy profile with the tissue biopsy and assess concordance. A total of 27 samples of circulating tumor DNA (ctDNA) collected from 9 breast cancer patients at three different time points and their matched formalin-fixed and paraffin-embedded (FFPE) samples of primary tumor were analyzed with targeted next-generation sequencing. Somatic pathogenic varia...
Source: Clinical Breast Cancer - August 13, 2020 Category: Cancer & Oncology Authors: Zelinova K, Jagelkova M, Laucekova Z, Bobrovska M, Dankova Z, Grendar M, Dokus K Tags: Mol Clin Oncol Source Type: research

Correlation between salivary and serum CA15-3 concentrations in patients with breast cancer.
a ENS Abstract The early detection of breast cancer enables the use of less aggressive treatment and increases patient survival. The transmembrane glycoprotein mucin 1, which is also known as cancer antigen 15-3 (CA15-3), is aberrantly glycosylated and overexpressed in a variety of epithelial cancers, and serves a crucial role in the progression of the disease. CA15-3 is currently used as a marker of breast cancer. In the present study, CA15-3 concentrations in saliva and blood of patients with breast cancer were evaluated to test new assays to detect salivary CA15-3 in addition to ELISA and its diagnostic value. ...
Source: Clinical Breast Cancer - July 29, 2020 Category: Cancer & Oncology Authors: Assad DX, Mascarenhas ECP, Normando AGC, Chardin H, Barra GB, Pratesi R, Nóbrega YKM, Acevedo AC, Guerra ENS Tags: Mol Clin Oncol Source Type: research

Predicting therapeutic efficacy of endocrine therapy for stage IV breast cancer by tumor-infiltrating lymphocytes.
Abstract The tumor immune environment not only modulates the effects of immunotherapy, but also the effects of other anticancer drugs and treatment outcomes. These immune responses may be evaluated by measuring tumor-infiltrating lymphocytes (TILs), which has been frequently verified clinically. In the present study, the prediction of the therapeutic effect of endocrine therapy by TILs on stage IV breast cancer was clinically analyzed. Data from 40 patients who underwent endocrine therapy as the initial drug therapy for stage IV breast cancer were used. The correlation between TILs, evaluated according to standard...
Source: Clinical Breast Cancer - July 29, 2020 Category: Cancer & Oncology Authors: Asano Y, Kashiwagi S, Goto W, Takada K, Takahashi K, Shibutani M, Amano R, Takashima T, Tomita S, Hirakawa K, Ohira M Tags: Mol Clin Oncol Source Type: research

Radiation dermatitis in patients treated with concurrent trastuzumab emtansine (T-DM1).
Abstract Trastuzumab Emtansine (T-DM1) improves outcomes for patients with HER2+ breast cancer, and is given concurrently with radiation. We have noted increased radiation dermatitis in these patients, which may have been underreported on the KATHERINE clinical trial, and call for clinicians to remain vigilant of unexpected toxicities with newly approved therapies. PMID: 32715108 [PubMed] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - July 29, 2020 Category: Cancer & Oncology Authors: Corbin KS, Breen WG, Strauss JB Tags: Clin Transl Radiat Oncol Source Type: research

Hot Flashes: Clinical Summary of the ONS Guidelines ™ for Cancer Treatment-Related Hot Flashes in Women With Breast Cancer and Men With Prostate Cancer.
Hot Flashes: Clinical Summary of the ONS Guidelines™ for Cancer Treatment-Related Hot Flashes in Women With Breast Cancer and Men With Prostate Cancer. Clin J Oncol Nurs. 2020 Aug 01;24(4):430-433 Authors: Kaplan M, Mahon SM, Lubejko BG, Ginex PK Abstract Cancer-related hot flashes are often a lasting and distressing side effect of hormone-blocking therapies that are most often experienced by women with breast cancer and men with prostate cancer treated with these therapies. Hot flashes have been defined as a sensation of heat that may be accompanied by facial flushing, perspiration, chills, hea...
Source: Clinical Breast Cancer - July 19, 2020 Category: Cancer & Oncology Authors: Kaplan M, Mahon SM, Lubejko BG, Ginex PK Tags: Clin J Oncol Nurs Source Type: research

Postdiagnosis Physical Activity: Association With Long-Term Fatigue and Sleep Disturbance in Older Adult Breast Cancer Survivors.
This article aimed to examine if postdiagnosis physical activity is associated with lower long-term fatigue and sleep disturbance in older adult breast cancer survivors. METHODS: Data were analyzed of a prospective cohort of 440 breast cancer survivors aged 65 years or older from the Women's Health Initiative study. Multiple linear and logistic regression models were used to examine associations of physical activity with fatigue and sleep disturbance. FINDINGS: Higher postdiagnosis physical activity was associated with lower long-term fatigue but was not associated with lower sleep disturbance after adjusting for...
Source: Clinical Breast Cancer - July 19, 2020 Category: Cancer & Oncology Authors: Vasbinder A, Reding KW, Wang D, Han CJ, Zaslavsky O, Langford D, Cespedes Feliciano EM, Barrington WE, Paskett ED Tags: Clin J Oncol Nurs Source Type: research

Is vimentin a potential prognostic factor for patients with triple-negative breast cancer?
CONCLUSION: None of the six proteins proved to be suitable prognostic factors for OS and DSF in patients with TNBC. PMID: 32266539 [PubMed - indexed for MEDLINE] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - July 14, 2020 Category: Cancer & Oncology Authors: Schmidt G, Solomayer EF, Bohle RM, Gerlinger C, Radosa JC, Endrikat J, Kasoha M Tags: J Cancer Res Clin Oncol Source Type: research

Enhanced cytotoxicity against solid tumors by bispecific antibody-armed CD19 CAR T cells: a proof-of-concept study.
CONCLUSIONS: HER2Bi- or EGFRBi-armed CART19 exhibited specific cytotoxicity against multiple HER2+/EGFR+/CD19- tumor targets in overnight and long-term serial killing assays. CART19 showed improved survival and were resistant to exhaustion after prolonged repeated exposure to tumor cells. PMID: 32449004 [PubMed - indexed for MEDLINE] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - July 14, 2020 Category: Cancer & Oncology Authors: Thakur A, Scholler J, Schalk DL, June CH, Lum LG Tags: J Cancer Res Clin Oncol Source Type: research

Cancer risks in patients with vitiligo: a Mendelian randomization study.
Abstract PURPOSE: Few studies have investigated the relationship between vitiligo and risks of various types of cancers, especially those other than skin cancer. Conventional observational studies are susceptible to potential confounders and inverse causation. With a Mendelian randomization approach, we were able to evaluate the causality between vitiligo and different cancer risks. METHODS: 37 vitiligo-related single-nucleotide polymorphisms identified by the published genome-wide association studies were used as instrumental variables in our study. Summary data of individual-level genetic information were o...
Source: Clinical Breast Cancer - July 14, 2020 Category: Cancer & Oncology Authors: Wen Y, Wu X, Peng H, Li C, Jiang Y, Liang H, Zhong R, Liu J, He J, Liang W Tags: J Cancer Res Clin Oncol Source Type: research

Breast cancer: are long-term and intermittent endocrine therapies equally effective?
CONCLUSION: Knowledge of initiation and growth of tumors with known effects of neo-ATs suggest that intermittent endocrine ATs may achieve the same results as EATs but with improved quality of life and survival because of fewer side effects and better compliance. The challenge for developments of repeated ATs becomes: how short is short enough. PMID: 32472445 [PubMed - indexed for MEDLINE] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - July 14, 2020 Category: Cancer & Oncology Authors: Engel J, Schubert-Fritschle G, Emeny R, Hölzel D Tags: J Cancer Res Clin Oncol Source Type: research

Cancer and Systemic Lupus Erythematosus.
Abstract Systemic lupus erythematosus is associated with a small overall increased cancer risk compared with the general population. This risk includes a 4-fold increased risk of non-Hodgkin lymphoma, but a decreased risk of other cancers (such as breast cancer). The pathophysiology underlying the increased risk of hematologic cancer is not fully understood, but many potential mechanisms have been proposed, including dysfunction of the tumor necrosis factor and other pathways. A decreased risk of breast, ovarian, and endometrial cancer might be driven by hormonal factors or lupus-related antibodies, but these link...
Source: Clinical Breast Cancer - July 9, 2020 Category: Cancer & Oncology Authors: Ladouceur A, Tessier-Cloutier B, Clarke AE, Ramsey-Goldman R, Gordon C, Hansen JE, Bernatsky S Tags: Rheum Dis Clin North Am Source Type: research