VOC pattern recognition of lung cancer: a comparative evaluation of different dog- and eNose-based strategies using different sampling materials.
Conclusion: Our data confirmed that the diagnostic accuracy of dogs depended on the type of dog training and on the carrier materials. A comparison of breath samples analysis with an eNose achieved better results for both, sensitivity and specificity than for dogs. The use of fleece masks or fleeces in glass tubes as a sampling material can be recommended as successful VOC carriers, encouraging their use for clinical screenings. PMID: 31311375 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - July 16, 2019 Category: Cancer & Oncology Authors: Biehl W, Hattesohl A, Jörres RA, Duell T, Althöhn U, Rembert Koczulla A, Schmetzer H Tags: Acta Oncol Source Type: research

Individualizing the radiotherapy target volume for glioblastoma using DTI-MRI: a phase 0 study on coverage of recurrences.
PMID: 31303079 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - July 15, 2019 Category: Cancer & Oncology Authors: Trip AK, Jensen MB, Kallehauge JF, Lukacova S Tags: Acta Oncol Source Type: research

Predicting late magnetic resonance image changes in glioma patients after proton therapy.
ml;hr A PMID: 31303083 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - July 15, 2019 Category: Cancer & Oncology Authors: Eulitz J, Troost EGC, Raschke F, Schulz E, Lutz B, Dutz A, Löck S, Wohlfahrt P, Enghardt W, Karpowitz C, Krause M, Lühr A Tags: Acta Oncol Source Type: research

Initial experiences with hippocampus-sparing whole-brain radiotherapy for lung cancer patients.
PMID: 31303085 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - July 15, 2019 Category: Cancer & Oncology Authors: Nielsen M, Kristiansen C, Schytte T, Hansen O Tags: Acta Oncol Source Type: research

Towards proton arc therapy: physical and biologically equivalent doses with increasing number of beams in pediatric brain irradiation.
Conclusion: Proton arc therapy has the potential to improve dose gradients to better spare cognitive brain structures. However, this is at the expense of increased low-dose/low-LET volumes, with possible implications for secondary cancer risks. PMID: 31303090 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - July 15, 2019 Category: Cancer & Oncology Authors: Toussaint L, Indelicato DJ, Holgersen KS, Petersen JBB, Stokkevåg CH, Lassen-Ramshad Y, Casares-Magaz O, Vestergaard A, Muren LP Tags: Acta Oncol Source Type: research

Perfusion CT radiomics as potential prognostic biomarker in head and neck squamous cell carcinoma.
r O PMID: 31304860 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - July 14, 2019 Category: Cancer & Oncology Authors: Bogowicz M, Tanadini-Lang S, Veit-Haibach P, Pruschy M, Bender S, Sharma A, Hüllner M, Studer G, Stieb S, Hemmatazad H, Glatz S, Guckenberger M, Riesterer O Tags: Acta Oncol Source Type: research

Patterns in ano-rectal dose maps and the risk of late toxicity after prostate IMRT.
Conclusions: To avoid fecal incontinence it is important to limit the portion of the anal canal irradiated. Our analysis confirms that rectal bleeding is a function of similar spatial dose parameters for patients treated with IMRT, compared to previous studies on patients treated with three-dimensional conformal radiotherapy. PMID: 31298076 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - July 12, 2019 Category: Cancer & Oncology Authors: Onjukka E, Fiorino C, Cicchetti A, Palorini F, Improta I, Gagliardi G, Cozzarini C, Degli Esposti C, Gabriele P, Valdagni R, Rancati T Tags: Acta Oncol Source Type: research

Completeness of pediatric cancer registration in the Finnish Cancer Registry.
PMID: 31290361 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - July 10, 2019 Category: Cancer & Oncology Authors: Jokela M, Leinonen MK, Malila N, Taskinen M, Madanat-Harjuoja LM Tags: Acta Oncol Source Type: research

Impact of social support on psychosocial symptoms and quality of life in cancer patients: results of a multilevel model approach from a longitudinal multicenter study.
Conclusions: Our findings provide evidence for the influence of PS and DI on psychosocial symptoms and HRQOL, and emphasize the importance of psycho-oncological interventions that strengthen PS and prevent or reduce DI for patients with cancer and their relatives. PMID: 31284793 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - July 9, 2019 Category: Cancer & Oncology Authors: Sauer C, Weis J, Faller H, Junne F, Hönig K, Bergelt C, Hornemann B, Stein B, Teufel M, Goerling U, Erim Y, Geiser F, Niecke A, Senf B, Weber D, Maatouk I Tags: Acta Oncol Source Type: research

Decreased symptom burden following surgery due to support from an interactive app for symptom management for patients with pancreatic and periampullary cancer.
Conclusion: The use of an app for management of patient-reported outcomes reduces symptom burdens six weeks after pancreaticoduodenectomy due to cancer. Interaktor is well accepted for patients choosing to participate and appears to facilitate supportive care needs and timely symptom management for this patient group. Future studies should also include cost-benefits and objective measures. PMID: 31284797 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - July 9, 2019 Category: Cancer & Oncology Authors: Gustavell T, Sundberg K, Segersvärd R, Wengström Y, Langius-Eklöf A Tags: Acta Oncol Source Type: research

Survivors' knowledge of their diagnosis, treatment and possible late adverse effects after autologous stem cell transplantation for lymphoma.
Conclusion: The majority of lymphoma survivors treated with HD-ASCT correctly recalled diagnosis and treatment, while knowledge of late AEs varied. Our findings point to information deficits in survivors at older age and with lower mental health related quality of life. They indicate benefit of follow-up to enhance education on late AEs in lymphoma survivors. PMID: 31286808 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - July 9, 2019 Category: Cancer & Oncology Authors: Simensen VC, Smeland KB, Kiserud CE, Dahl AA, Bersvendsen HS, Fluge Ø, Fagerli UM, Fosså A Tags: Acta Oncol Source Type: research

Patterns of survival and surgical treatment in lung cancer patients in Estonia by histologic type and stage, 1996-2016.
Conclusions: We observed a substantial improvement of relative survival, with considerable variations across patient groups. After adjustment for age, gender and histology, a significant survival increase over time was seen for all stages. The considerable survival gain observed for localized LC can largely be attributed to rapidly growing proportion of surgically treated patients. Further investigation of LC management practices, particularly the use of non-surgical treatment options is warranted. PMID: 31286812 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - July 9, 2019 Category: Cancer & Oncology Authors: Innos K, Oselin K, Laisaar T, Aareleid T Tags: Acta Oncol Source Type: research

AR-V7 expression in circulating tumor cells as a potential prognostic marker in metastatic hormone-sensitive prostate cancer.
e;n K PMID: 31286815 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - July 9, 2019 Category: Cancer & Oncology Authors: Josefsson A, Damber JE, Welén K Tags: Acta Oncol Source Type: research

DAHANCA 9 - a randomized multicenter study to compare accelerated normo-fractionated radiotherapy with accelerated hyperfractionated radiotherapy in patients with primary squamous cell carcinoma of the head and neck (HNSCC).
PMID: 31282236 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - July 8, 2019 Category: Cancer & Oncology Authors: Evensen JF, Sand Hansen H, Overgaard M, Johansen J, Andersen LJ, Overgaard J Tags: Acta Oncol Source Type: research

Human papillomavirus, radiation dose and survival of patients with anal cancer.
Abstract Purpose: To determine if anal cancer patients with HPV positive disease have different overall survival (OS) compared to those with HPV negative disease, and to elucidate differences in the association between radiation dose and OS. Patients and methods: We utilized the National Cancer Database (NCDB) registry to identify a cohort of non-metastatic anal cancer patients treated with curative intent between 2008 and 2014. Propensity score matching was used to account for potential selection bias between patients with HPV positive and negative disease. Multivariable Cox regression was used to determine the a...
Source: Acta Oncologica - July 8, 2019 Category: Cancer & Oncology Authors: Kabarriti R, Brodin NP, Ohri N, Narang R, Huang R, Chuy JW, Rajdev LN, Kalnicki S, Guha C, Garg MK Tags: Acta Oncol Source Type: research

Outcome of treatment in patients with small cell lung cancer in poor performance status.
Abstract Background: Patients with small cell lung cancer (SCLC) with poor performance status (PS) especially in the elderly may not benefit from chemotherapy. The aim of this study was to compare survival of treated patients with PS 3-4 with untreated patients. Material and methods: We reviewed the medical records and pathology data for 448 patients diagnosed with small cell carcinoma from 2010 to 2015 and selected all patients in PS 3-4 for review. Results: A total of 87 patients fulfilled the inclusion criteria. Of these, 53 (61%) received chemotherapy (CT), while 34 (39%) did not. The median overall survival (...
Source: Acta Oncologica - July 8, 2019 Category: Cancer & Oncology Authors: Bahij R, Starup Jeppesen S, Ege Olsen K, Halekoh U, Holmskov K, Hansen O Tags: Acta Oncol Source Type: research

The effect of tumor laterality on survival for non-small cell lung cancer patients treated with radiotherapy.
Conclusion: This study did not verify that laterality has a significant impact on survival in LA-NSCLC patients treated with curative intended RT. PMID: 31271075 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - July 4, 2019 Category: Cancer & Oncology Authors: Jørgensen N, Meline EL, Jeppesen SS, Hansen O, Nielsen M, Schytte T Tags: Acta Oncol Source Type: research

Plan-library supported automated replanning for online-adaptive intensity-modulated proton therapy of cervical cancer.
Conclusion: The automated prior-plan adaptation method can successfully adapt for the large day-to-day variations observed in cervical cancer patients. PMID: 31271076 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - July 4, 2019 Category: Cancer & Oncology Authors: Jagt TZ, Breedveld S, van Haveren R, Nout RA, Astreinidou E, Heijmen BJM, Hoogeman MS Tags: Acta Oncol Source Type: research

Inter-observer variability in target delineation increases during adaptive treatment of head-and-neck and lung cancer.
Conclusion: IOV in target volume delineation increases during treatment, where a disparity in institutional adaptation practices adds to the conventional causes of IOV. Consensus guidelines are urgently needed. PMID: 31271079 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - July 4, 2019 Category: Cancer & Oncology Authors: Apolle R, Appold S, Bijl HP, Blanchard P, Bussink J, Faivre-Finn C, Khalifa J, Laprie A, Lievens Y, Madani I, Ruffier A, de Ruysscher D, van Elmpt W, Troost EGC Tags: Acta Oncol Source Type: research

Distinguishing recurrence and new primary tumor as well as the origin of neck metastases in head and neck cancer clinical trials by targeted DNA sequencing.
ard J PMID: 31271080 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - July 4, 2019 Category: Cancer & Oncology Authors: Lilja-Fischer JK, Saksø M, Stougaard M, Steiniche T, Overgaard J Tags: Acta Oncol Source Type: research

Emerging trends in the treatment of rectal cancer.
Abstract The conventional treatment for cT3-T4 or node-positive clinically resectable rectal cancer is long course preoperative chemoradiation followed by surgery and postoperative adjuvant chemotherapy. Disadvantages of this approach include possible overtreatment of patients, 6 weeks of daily radiation treatment, and undetected metastatic disease. There are a number of emerging trends which are changing this approach to treatment. Selected topics included in this manuscript include the selective use of pelvic radiation, the role of radiation for a positive radial margin, the interval between radiation and s...
Source: Acta Oncologica - July 4, 2019 Category: Cancer & Oncology Authors: Minsky BD Tags: Acta Oncol Source Type: research

Radiation doses to brain substructures associated with cognition in radiotherapy of pediatric brain tumors.
Conclusion: While there were notable differences in the dose patterns between the groups, the extent of estimated IQ decline depended more on the model applied. This inter-model variability should be considered in dose-effect assessments on cognitive outcomes of pediatric patients. PMID: 31271084 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - July 4, 2019 Category: Cancer & Oncology Authors: Toussaint L, Indelicato DJ, Stokkevåg CH, Lassen-Ramshad Y, Pedro C, Mikkelsen R, Di Pinto M, Li Z, Flampouri S, Vestergaard A, Petersen JBB, Schrøder H, Høyer M, Muren LP Tags: Acta Oncol Source Type: research

Dual-energy material decomposition for cone-beam computed tomography in image-guided radiotherapy.
Conclusion: Monochromatic DE images from material decomposition can improve soft tissue contrast-to-noise ratio and metal artifact reduction. Improvements are limited, however, and new artifacts were also introduced by the DE algorithm. PMID: 31271086 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - July 4, 2019 Category: Cancer & Oncology Authors: Skaarup M, Edmund JM, Dorn S, Kachelriess M, Vogelius IR Tags: Acta Oncol Source Type: research

Towards a novel small animal proton irradiation platform: the SIRMIO project.
Würl M Abstract Background: Precision small animal radiotherapy research is a young emerging field aiming to provide new experimental insights into tumor and normal tissue models in different microenvironments, to unravel complex mechanisms of radiation damage in target and non-target tissues and assess efficacy of novel therapeutic strategies. For photon therapy, modern small animal radiotherapy research platforms have been developed over the last years and are meanwhile commercially available. Conversely, for proton therapy, which holds potential for an even superior outcome than photon therapy, no commerci...
Source: Acta Oncologica - July 4, 2019 Category: Cancer & Oncology Authors: Parodi K, Assmann W, Belka C, Bortfeldt J, Clevert DA, Dedes G, Kalunga R, Kundel S, Kurichiyanil N, Lämmer P, Lascaud J, Lauber K, Lovatti G, Meyer S, Nitta M, Pinto M, Safari MJ, Schnürle K, Schreiber J, Thirolf PG, Wieser HP, Würl M Tags: Acta Oncol Source Type: research

Radiation tattoos mimicking melanoma: a clinical observation.
PMID: 31271092 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - July 4, 2019 Category: Cancer & Oncology Authors: Nazarian RS, Amin B, Papalezova K, Ohri N, McLellan BN Tags: Acta Oncol Source Type: research

Evaluation of proton and photon dose distributions recalculated on 2D and 3D Unet-generated pseudoCTs from T1-weighted MR head scans.
Conclusions: Image analysis revealed a slight advantage of 2D Unets compared to 3D Unets. Similar dose calculation performance was reached for the 2D and 3D network. PMID: 31271093 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - July 4, 2019 Category: Cancer & Oncology Authors: Neppl S, Landry G, Kurz C, Hansen DC, Hoyle B, Stöcklein S, Seidensticker M, Weller J, Belka C, Parodi K, Kamp F Tags: Acta Oncol Source Type: research

Survival after stereotactic radiotherapy in patients with early-stage non-small cell lung cancer.
Conclusions: The OS was influenced by age, but the study suggests that a cut point of 75 year is inappropriate in evaluating the effect of old age on survival. Poor PS was associated with poor OS. CCI influenced OS, but not LCSS, which was only affected by PS and tumor size. PMID: 31271094 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - July 4, 2019 Category: Cancer & Oncology Authors: Hansen O, Kristiansen C, Nielsen M, Schytte T, Starup Jeppesen S Tags: Acta Oncol Source Type: research

Intensity modulated proton therapy plan generation in under ten seconds.
Abstract Background: Treatment planning for intensity modulated proton therapy (IMPT) can be significantly improved by reducing the time for plan calculation, facilitating efficient sampling of the large solution space characteristic of IMPT treatments. Additionally, fast plan generation is a key for online adaptive treatments, where the adapted plan needs to be ideally available in a few seconds. However, plan generation is a computationally demanding task and, although dose restoration methods for adaptive therapy have been proposed, computation times remain problematic. Material and methods: IMPT plan generatio...
Source: Acta Oncologica - July 4, 2019 Category: Cancer & Oncology Authors: Matter M, Nenoff L, Meier G, Weber DC, Lomax AJ, Albertini F Tags: Acta Oncol Source Type: research

An investigative expansion of a competing risk model for first failure site in locally advanced non-small cell lung cancer.
aring;rd L Abstract Introduction: We hypothesized that gross tumor volume (GTV) of primary tumor (GTVT) and nodal volumes (GTVN) were predictors of first failure site in non-small cell lung cancer (NSCLC). We aimed at also comparing the prognostic model's complexity to its ability to generate absolute risk predictions with emphasis on variables available at the time of diagnosis. Materials and methods: Three hundred and forty-two patients treated with definitive chemoradiotherapy (CRT) for adenocarcinoma (AC) or squamous cell carcinoma (SCC) in 2009-2017 were analyzed. Clinical data, standardized uptake values on ...
Source: Acta Oncologica - July 4, 2019 Category: Cancer & Oncology Authors: Lacoppidan T, Vogelius IR, Pøhl M, Strange M, Persson GF, Nygård L Tags: Acta Oncol Source Type: research

Influence of mutagenic versus non-mutagenic pre-operative chemotherapy on the immune infiltration of residual breast cancer.
Conclusions: Significant increase of StrTIL in the residual disease was observed in patients treated with the highly (platinum), moderately (cyclophosphamide) and marginally mutagenic chemotherapeutic agents (taxane, anthracycline). Increase in StrTIL in residual cancer compared to pretreatment tumor tissue is associated with improved distant metastasis-free survival in cases with HR negative breast carcinoma. PMID: 31271119 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - July 4, 2019 Category: Cancer & Oncology Authors: Tőkés AM, Rusz O, Cserni G, Tóth E, Rubovszky G, Tőkés T, Vízkeleti L, Reiniger L, Kószó R, Kahán Z, Kulka J, Donia M, Vörös A, Szallasi Z Tags: Acta Oncol Source Type: research

Factors determining the effect of prophylactic cranial irradiation (PCI) in patients with stage-III nonsmall cell lung cancer: exploratory subgroup analyses of the NVALT-11/DLCRG-02 phase-III study.
PMID: 31256737 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - July 1, 2019 Category: Cancer & Oncology Authors: Witlox WJA, Ramaekers BLT, Groen HJM, Dingemans AM, Praag J, Belderbos J, van der Noort V, van Tinteren H, Joore MA, De Ruysscher DKM Tags: Acta Oncol Source Type: research

LINAC based stereotactic radiosurgery for multiple brain metastases: guidance for clinical implementation.
Abstract Introduction: Stereotactic radiosurgery (SRS) is a promising treatment option for patients with multiple brain metastases (BM). Recent technical advances have made LINAC based SRS a patient friendly technique, allowing for accurate patient positioning and a short treatment time. Since SRS is increasingly being used for patients with multiple BM, it remains essential that SRS be performed with the highest achievable quality in order to prevent unnecessary complications such as radionecrosis. The purpose of this article is to provide guidance for high-quality LINAC based SRS for patients with BM, with a foc...
Source: Acta Oncologica - July 1, 2019 Category: Cancer & Oncology Authors: Hartgerink D, Swinnen A, Roberge D, Nichol A, Zygmanski P, Yin FF, Deblois F, Hurkmans C, Ong CL, Bruynzeel A, Aizer A, Fiveash J, Kirckpatrick J, Guckenberger M, Andratschke N, de Ruysscher D, Popple R, Zindler J Tags: Acta Oncol Source Type: research

Improving the prognosis for lung cancer patients.
PMID: 31257968 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - July 1, 2019 Category: Cancer & Oncology Authors: Clausen MM, Langer SW Tags: Acta Oncol Source Type: research

Arsenic trioxide and tetraarsenic oxide induce cytotoxicity and have a synergistic effect with cisplatin in paclitaxel-resistant ovarian cancer cells.
In this study, the cytotoxicity of arsenic compounds on ovarian cancer cell lines and the anticancer activity of the combination of arsenic compounds and cisplatin IN chemoresistant ovarian cancer cells were investigated. Methods: We investigated the cytotoxicity of As2O3 and As4O6 and their combinations with cisplatin in the paclitaxel-sensitive ovarian cancer cell lines SKOV3ip1 and HeyA8 and paclitaxel-resistant ovarian cancer cell lines SKOV3TRip2 and HeyA8-MDR. Growth and apoptosis were evaluated by MTT assay and annexin V assay using flow cytometry, respectively. For detection of apoptotic cells, immunofluorescence w...
Source: Acta Oncologica - July 1, 2019 Category: Cancer & Oncology Authors: Byun JM, Lee DS, Landen CN, Kim DH, Kim YN, Lee KB, Sung MS, Park SG, Jeong DH Tags: Acta Oncol Source Type: research

Towards FLASH proton therapy: the impact of treatment planning and machine characteristics on achievable dose rates.
Conclusion: FLASH dose rates were not achieved for conventional planning and clinical spot-scanning machines. As such, increased spot-wise beam intensities, spot-reduced planning, hypofractionation and arc-shoot-through plans were required to achieve FLASH compatible dose rates. PMID: 31241377 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - June 26, 2019 Category: Cancer & Oncology Authors: van de Water S, Safai S, Schippers JM, Weber DC, Lomax AJ Tags: Acta Oncol Source Type: research

Relationship between patient and physician-rated xerostomia and dose distribution to the oral cavity and salivary glands for head and neck cancer patients after radiotherapy.
Conclusion: Patients tended to report higher scores of xerostomia than the physician. PCA indicated a complex relation between doses to the OAR and xerostomia scores, showing e.g., that reducing doses in one organ was on the expense of increased dose to another organ. PMID: 31241381 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - June 26, 2019 Category: Cancer & Oncology Authors: Kaae JK, Johnsen L, Hansen CR, Kristensen MH, Brink C, Eriksen JG Tags: Acta Oncol Source Type: research

A theoretical investigation of adequate range uncertainty margins in proton treatment planning to preserve tumor control probability.
Conclusion: The details of the underlying cancer cell distribution characteristics do impact the adequate dose arrangements, and for opposing beams a non-conventional dose distribution shape is often advantageous. PMID: 31241385 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - June 26, 2019 Category: Cancer & Oncology Authors: Taasti VT, Jeong J, Jackson A, Deasy JO Tags: Acta Oncol Source Type: research

First clinical experiences with a high field 1.5 T MR linac.
Conclusion: MRL treatments, including daily MRIs, plan adaptation, and accurate dose delivery, are possible within a clinically acceptable timeframe and well tolerated by the patients. PMID: 31241387 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - June 26, 2019 Category: Cancer & Oncology Authors: Bertelsen AS, Schytte T, Møller PK, Mahmood F, Riis HL, Gottlieb KL, Agergaard SN, Dysager L, Hansen O, Gornitzka J, Veldhuizen E, ODwyer DB, Christiansen RL, Nielsen M, Jensen HR, Brink C, Bernchou U Tags: Acta Oncol Source Type: research

Assessing the size of large colorectal polyps.
PMID: 31241388 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - June 26, 2019 Category: Cancer & Oncology Authors: Rubio CA Tags: Acta Oncol Source Type: research

Bringing Europe together in building clinical evidence for proton therapy - the EPTN-ESTRO-EORTC endeavor.
PMID: 31241391 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - June 26, 2019 Category: Cancer & Oncology Authors: Weber DC, Grau C, Lim PS, Georg D, Lievens Y Tags: Acta Oncol Source Type: research

Cancer patients' interest in participating in cancer rehabilitation.
Conclusions: The interest of cancer rehabilitation of all approached patients in this study were 21%. Most interested were women, young patients, university educated and those who received their diagnosis ≥12 months earlier. About 30% of the participating cancer patients reported an interest of information and supportive groups, physical training and support from a hospital social worker. Patients with low level of education reported a low interest in CR. There are limitations in rehabilitation accessibility and that might affect a person's motivation to participate in this study. PMID: 31241428 [PubMed - as suppli...
Source: Acta Oncologica - June 26, 2019 Category: Cancer & Oncology Authors: Ohlsson-Nevo E, Alkebro I, Ahlgren J Tags: Acta Oncol Source Type: research

Neoadjuvant stereotactic body radiation therapy for nonmetastatic pancreatic adenocarcinoma.
Abstract Background: Neoadjuvant therapy is a strategy for resectable and borderline resectable pancreatic cancer, but a consensus approach regarding optimal management is undetermined. Neoadjuvant options include chemotherapy with/without radiotherapy. Stereotactic body radiation therapy (SBRT) is a novel radiation technique that may provide benefit over conventionally fractionated radiation therapy (CFRT) in the neoadjuvant setting. The purpose of the present study is to determine neoadjuvant treatment with SBRT to other neoadjuvant treatment options for patients with resectable pancreatic cancer. Material and m...
Source: Acta Oncologica - June 25, 2019 Category: Cancer & Oncology Authors: Jiang W, Haque W, Verma V, Butler EB, Teh BS Tags: Acta Oncol Source Type: research

Five-year oncological outcomes after selective neoadjuvant radiotherapy for resectable rectal cancer.
Conclusions: Patients selected for SCRT had a lower rate of local recurrence than patients selected for surgery alone, but were more likely to develop distant metastasis. There was no difference in overall survival. With low local recurrence rates, distant metastasis is the predominant risk for patients with resectable rectal cancer. PMID: 31237192 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - June 25, 2019 Category: Cancer & Oncology Authors: Banwell VC, Phillips HA, Duff MJ, Speake D, McLean C, Williams LJ, He Y, Paterson HM Tags: Acta Oncol Source Type: research

Pre-operative plasma cell-free circulating tumor DNA and serum protein tumor markers as predictors of lung adenocarcinoma recurrence.
H, Planck M Abstract Background: Lung cancer patients have a risk of recurrence even after curatively intended surgery. Cell-free circulating tumor DNA (ctDNA) and circulating tumor marker measurements are easily accessible through peripheral blood and could potentially identify patients with worse prognosis. The aim of this study was to examine ctDNA in pre-operative plasma and the role of tumor markers in pre-operative serum for their predictive potential on risk of tumor recurrence. Methods: Mutation analysis by 26-gene targeted sequencing was performed on 157 lung adenocarcinomas (ACs) from patients surgically...
Source: Acta Oncologica - June 24, 2019 Category: Cancer & Oncology Authors: Isaksson S, George AM, Jönsson M, Cirenajwis H, Jönsson P, Bendahl PO, Brunnström H, Staaf J, Saal LH, Planck M Tags: Acta Oncol Source Type: research

Outside the box of immunotherapy - new hope for patients with advanced urothelial cancer.
e;n A PMID: 31232133 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - June 24, 2019 Category: Cancer & Oncology Authors: Ullén A Tags: Acta Oncol Source Type: research

Adjuvant radiotherapy-induced cardiac changes among patients with early breast cancer: a three-year follow-up study.
In this study, we evaluate the evolution of cardiac changes during a three-year follow-up after adjuvant breast radiotherapy (RT). Methods: Sixty patients with left-sided and 20 patients with right-sided early stage breast cancer without chemotherapy were included in this prospective study. Echocardiography and cardiac biomarkers were evaluated before, immediately after and 3 years after RT. Radiation doses to cardiac structures were calculated. Results: In echocardiography, left ventricle (LV) systolic measurements had impaired at 3 years compared to baseline: the mean global longitudinal strain (GLS) worsened from -18&th...
Source: Acta Oncologica - June 20, 2019 Category: Cancer & Oncology Authors: Skyttä T, Tuohinen S, Luukkaala T, Virtanen V, Raatikainen P, Kellokumpu-Lehtinen PL Tags: Acta Oncol Source Type: research

Quality assessment criteria: psychometric properties of measurement tools for cancer related fatigue.
Conclusion: Further psychometric testing is required for other scales. Developing a universally-defined tool kit for the assessment of cancer-related fatigue may help clarify the concept of fatigue and promote a systematic approach to fatigue measurement. PMID: 31204538 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - June 17, 2019 Category: Cancer & Oncology Authors: Al Maqbali M, Hughes C, Gracey J, Rankin J, Dunwoody L, Hacker E Tags: Acta Oncol Source Type: research

Deformable image registration for radiation therapy: principle, methods, applications and evaluation.
Conclusions: DIR is increasingly important in RT applications, from planning to toxicity prediction. DIR is routinely used to reduce the workload of contour propagation. However, its use for complex dosimetric applications must be carefully evaluated by combining quantitative and qualitative analyses. PMID: 31155990 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - June 3, 2019 Category: Cancer & Oncology Authors: Rigaud B, Simon A, Castelli J, Lafond C, Acosta O, Haigron P, Cazoulat G, de Crevoisier R Tags: Acta Oncol Source Type: research

Clinical results of proton therapy reirradiation for recurrent nasopharyngeal carcinoma.
Conclusions: Our initial results with the use of modern PT for reirradiation of recurrent NPC patients are encouraging. Favorable LC and OS rates were obtained at the cost of acceptable severe late toxicity. PMID: 31155998 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - June 3, 2019 Category: Cancer & Oncology Authors: Dionisi F, Croci S, Giacomelli I, Cianchetti M, Caldara A, Bertolin M, Vanoni V, Pertile R, Widesott L, Farace P, Schwarz M, Amichetti M Tags: Acta Oncol Source Type: research

Real-world data on PD-1 inhibitor therapy in metastatic melanoma.
Conclusions: The efficacy and safety of PD1 inhibitors in routine clinical practice appear comparable to that described in clinical trials. PMID: 31151362 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - May 31, 2019 Category: Cancer & Oncology Authors: Arheden A, Skalenius J, Bjursten S, Stierner U, Ny L, Levin M, Jespersen H Tags: Acta Oncol Source Type: research