Comorbidity and early death in Danish stage I lung cancer patients - an individualised approach.
Abstract Background: Comorbidity is an important prognostic marker and a treatment indicator for lung cancer patients. Register-based studies often describe the burden of comorbidity by the Charlson comorbidity index (CCI) based on hospital discharge data. We assessed the association between somatic and psychiatric comorbidity and death within one year in early lung cancer and, furthermore, the burden of comorbidity according to treatment type.Material and methods: We conducted a population-based matched case-control study of stage I lung cancer identifying all treated patients who died (all-cause) within one year...
Source: Acta Oncologica - May 28, 2020 Category: Cancer & Oncology Authors: Christensen NL, Rasmussen TR, Hansen KH, Christensen J, Dalton SO Tags: Acta Oncol Source Type: research

Interindividual changes in peak oxygen consumption in patients with colorectal cancer following endurance training: a secondary analysis of the I-WALK-CRC study.
en JF PMID: 32459127 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - May 27, 2020 Category: Cancer & Oncology Authors: Thomsen SN, Sundberg A, Osterkamp J, Thorsen-Streit S, Østerlind K, Krarup PM, Vistisen K, Pedersen BK, Christensen JF Tags: Acta Oncol Source Type: research

Desloratadine and loratadine stand out among common H1-antihistamines for association with improved breast cancer survival.
Abstract Background: As tumors maintain an inflammatory microenvironment, anti-inflammatory medication can be useful in cancer therapy. We have previously shown an association with improved survival in melanoma for use of the H1-antihistamines desloratadine and loratadine, and here we examine use of H1-antihistamines and breast cancer mortality.Material and methods: We investigated use of the six major H1-antihistamines (cetirizine, clemastine, desloratadine, ebastine, fexofenadine and loratadine) and breast cancer-specific and overall mortality in a nation-wide register-based study of all 61,627 Swedish women dia...
Source: Acta Oncologica - May 27, 2020 Category: Cancer & Oncology Authors: Fritz I, Wagner P, Broberg P, Einefors R, Olsson H Tags: Acta Oncol Source Type: research

Metastasis directed treatment of brain metastases from colorectal cancer - a Danish population-based cohort study.
We examined patient characteristics and survival for patients treated with a localized modality for BM from CRC in a nationwide population-based study.Methods: A registry-based cohort study of all patients with a resected primary colorectal cancer and localized treatment of BM during 2000-2013. We computed descriptive statistics and analysed overall survival by the Kaplan-Meier method and Cox regression.Results: A total of 38131 patients had surgery for a primary CRC and 235 patients were recorded with a metastasis directed treatment for BM, comprising resection alone (n = 158), SRT alone (n = 5...
Source: Acta Oncologica - May 22, 2020 Category: Cancer & Oncology Authors: Boysen AK, Ording AG, Astradsson A, Høyer M, Spindler KL Tags: Acta Oncol Source Type: research

The effect of radiation therapy on the objective response and outcomes with nivolumab for hepatocellular carcinoma.
PMID: 32441551 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - May 22, 2020 Category: Cancer & Oncology Authors: Smith WH, Law AS, Hulkower M, McGee HM, Lehrer EJ, Schwartz M, Taouli B, Sung M, Buckstein M Tags: Acta Oncol Source Type: research

First system for fully-automated multi-criterial treatment planning for a high-magnetic field MR-Linac applied to rectal cancer.
Conclusions: A system for fully automated multi-criterial planning for a 1.5 T MR-Linac was developed and tested for rectal cancer patients. Automated planning resulted in major reductions in planning workload and time, while plan quality improved. Negative impact of the high magnetic field on the dose distributions could be avoided. PMID: 32436450 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - May 21, 2020 Category: Cancer & Oncology Authors: Bijman R, Rossi L, Janssen T, de Ruiter P, Carbaat C, van Triest B, Breedveld S, Sonke JJ, Heijmen B Tags: Acta Oncol Source Type: research

Target miss using PTV-based IMRT compared to robust optimization via coverage probability concept in prostate cancer.
Conclusions: Probabilistic dose-escalated IMRT was feasible in this prospective study. Comparison of the CovP-concept with PTV-based IMRT revealed superiority with regard to target-coverage and sparing of OARs. The CovP-concept implements a robust plan optimization strategy for organ deformation and motions and could, therefore, serve as a less demanding compromise on the way to adaptive IGRT avoiding daily time-consuming re-planning. SUMMARYWe evaluated the robustness of coverage probability (CovP)-based IMRT plans within a prospective study for prostate cancer radiotherapy. The treatment plans were compared with newly ca...
Source: Acta Oncologica - May 21, 2020 Category: Cancer & Oncology Authors: Outaggarts Z, Wegener D, Berger B, Zips D, Paulsen F, Bleif M, Thorwarth D, Alber M, Dohm O, Müller AC Tags: Acta Oncol Source Type: research

Clinical implications of variable relative biological effectiveness in proton therapy for prostate cancer.
Abstract Purpose: To study the potential consequences of differences in the evaluation of variable versus uniform relative biological effectiveness calculations in proton radiotherapy for prostate cancer.Methods and material: Experimental data with proton beams suggest that relative biological effectiveness increases with linear energy transfer. This relation also depends on the [Formula: see text] ratio, characteristic of a tissue and a considered endpoint. Three phenomenological models (Carabe et al., Wedenberg et al. and McNamara et al.) are compared to a mechanistic model based on microdosimetry...
Source: Acta Oncologica - May 19, 2020 Category: Cancer & Oncology Authors: Bertolet A, Carabe-Fernandez A Tags: Acta Oncol Source Type: research

Cancer patients' preferred and perceived level of involvement in treatment decision-making: an epidemiological study.
Conclusion: The majority of patients with cancer wanted to be involved in medical decisions. Many patients perceived a high level of shared decision-making. However, many patients' level of involvement did not fit their preference. This study provides a solid basis for efforts to improve shared decision-making in German cancer care. PMID: 32427015 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - May 19, 2020 Category: Cancer & Oncology Authors: Hahlweg P, Kriston L, Scholl I, Brähler E, Faller H, Schulz H, Weis J, Koch U, Wegscheider K, Mehnert A, Härter M Tags: Acta Oncol Source Type: research

A novel energy sequence optimization algorithm for efficient spot-scanning proton arc (SPArc) treatment delivery.
Conclusions: The SPArc_seq optimization algorithm could effectively reduce the BDT compared to the original SPArc algorithm. The improved efficiency of the SPArc_seq algorithm has the potential to increase patient throughput, thereby reducing the operation cost of proton therapy. PMID: 32421375 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - May 18, 2020 Category: Cancer & Oncology Authors: Liu G, Li X, Zhao L, Zheng W, Qin A, Zhang S, Stevens C, Yan D, Kabolizadeh P, Ding X Tags: Acta Oncol Source Type: research

Increase of cervical cancer incidence in Sweden in relation to screening history: population cohort study.
Conclusion: The results suggest that the overall increase is associated with an increased cancer risk in women adequately screened with normal cytological results. Possibly, precursor lesions missed in one screening round might result in detection of early stage invasive cancer in the subsequent screening. PMID: 32421420 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - May 18, 2020 Category: Cancer & Oncology Authors: Wang J, Andrae B, Strander B, Sparén P, Dillner J Tags: Acta Oncol Source Type: research

Initial clinical outcomes for prostate cancer patients undergoing adjuvant or salvage proton therapy after radical prostatectomy.
PMID: 32421456 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - May 18, 2020 Category: Cancer & Oncology Authors: Deville C, Hwang WT, Barsky AR, Both S, Christodouleas JP, Bekelman JE, Tochner Z, Vapiwala N Tags: Acta Oncol Source Type: research

Tumour control probability after Ruthenium-106 brachytherapy for choroidal melanomas.
Abstract Purpose: Ruthenium-106 (Ru-106) brachytherapy is a common eye-preserving treatment for choroidal melanomas. However, a dose-response model describing the relationship between the actual delivered tumour dose and tumour control has, to the best of our knowledge, not previously been quantified for Ru-106 brachytherapy; we aimed to rectify this.Material and methods: We considered consecutive patients with primary choroidal melanomas, treated with Ru-106 brachytherapy (2005-2014). Dosimetric plans were retrospectively recreated using 3D image-guided planning software. Pre-treatment fundus photographies were u...
Source: Acta Oncologica - May 15, 2020 Category: Cancer & Oncology Authors: Espensen CA, Appelt AL, Fog LS, Thariat J, Gothelf AB, Aznar MC, Kiilgaard JF Tags: Acta Oncol Source Type: research

Negative illness perceptions are related to more fatigue among haematological cancer survivors: a PROFILES study.
Conclusion: Those who experience more consequences of their disease, attribute more symptoms to their illness, and have a poorer illness understanding, have a higher risk to experience substantial levels of fatigue even years after diagnosis. Psychological interventions changing these illness perceptions may be beneficial in reducing fatigue among haematological cancer survivors. PMID: 32412348 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - May 15, 2020 Category: Cancer & Oncology Authors: Schoormans D, Jansen M, Mols F, Oerlemans S Tags: Acta Oncol Source Type: research

Rate of locoregional recurrence among patients with oropharyngeal squamous cell carcinoma with known HPV status: a systematic review.
Conclusion: Recurrence rates for HPV-positive and -negative OPSCC patients were 9% and 26%, respectively, equating to an almost three times higher rate of locoregional recurrence among HPV-negative patients compared to HPV-positive patients. PMID: 32406799 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - May 14, 2020 Category: Cancer & Oncology Authors: Asheer J, Jensen JS, Grønhøj C, Jakobsen KK, Buchwald CV Tags: Acta Oncol Source Type: research

Tumor volume regression during neoadjuvant chemoradiotherapy for esophageal cancer: a prospective study with weekly MRI.
Conclusion: Based on weekly MRI scanning during nCRT for esophageal cancer, a considerable decrease in tumor volume was observed during treatment. Volume regression and consequential anatomical changes suggest the possible benefit of adaptive radiotherapy. PMID: 32400242 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - May 13, 2020 Category: Cancer & Oncology Authors: Defize IL, Boekhoff MR, Borggreve AS, van Lier ALHMW, Takahashi N, Haj Mohammad N, Ruurda JP, van Hillegersberg R, Mook S, Meijer GJ Tags: Acta Oncol Source Type: research

Maintenance therapy and drug holiday in sarcoma patients: systematic review.
Conclusions: Data about both maintenance and drug holiday are spare in sarcoma management. PMID: 32400254 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - May 13, 2020 Category: Cancer & Oncology Authors: Lebellec L, Defachelles AS, Cren PY, Penel N Tags: Acta Oncol Source Type: research

Socioeconomic inequalities in gastric cancer incidence in Canada: 1992-2010.
PMID: 32401113 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - May 13, 2020 Category: Cancer & Oncology Authors: Willis K, Hajizadeh M Tags: Acta Oncol Source Type: research

National e-library for standardized chemotherapy regimens.
ing; PMID: 32401129 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - May 13, 2020 Category: Cancer & Oncology Authors: Fyhr A, Borell J, Jerkeman M, Ek Å Tags: Acta Oncol Source Type: research

Early progression of breast cancer during neoadjuvant chemotherapy may predict poorer prognoses.
Conclusions: An early MRI assessment after two NACT cycles, specifically of the tumour's axillary lymph nodes, has the potential to predict short-term BCSS in patients with locally advanced HER2-negative breast cancers. PMID: 32394761 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - May 12, 2020 Category: Cancer & Oncology Authors: Myller S, Ipatti P, Jääskeläinen A, Haapasaari KM, Jukkola A, Karihtala P Tags: Acta Oncol Source Type: research

Image-guided hypofractionated double-scattering proton therapy in the management of centrally-located early-stage non-small cell lung cancer.
Conclusion: Image-guided hypofractionated PT for centrally-located early-stage NSCLC provides excellent local control with low rates of grade ≥3 toxicities. For tumors in sensitive locations, PT may provide safer treatment than photon-based treatments due to its dosimetric advantages. PMID: 32394776 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - May 12, 2020 Category: Cancer & Oncology Authors: Kharod SM, Nichols RC, Henderson RH, Morris CG, Pham DC, Seeram VK, Jones LM, Antonio-Miranda M, Huh S, Li Z, Hoppe BS Tags: Acta Oncol Source Type: research

The value of sorafenib trough levels in patients with advanced hepatocellular carcinoma - a substudy of the SORAMIC trial.
Conclusions: In patients with advanced HCC treated with sorafenib, the administered dose, trough levels of sorafenib or M2, and clinical outcomes were poorly correlated. Toxicity-adjusted dosing remains the standard for sorafenib treatment. PMID: 32366155 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - May 5, 2020 Category: Cancer & Oncology Authors: Labeur TA, Hofsink Q, Takkenberg RB, van Delden OM, Mathôt RAA, Schinner R, Malfertheiner P, Amthauer H, Schütte K, Basu B, Kuhl C, Mayerle J, Ricke J, Klümpen HJ Tags: Acta Oncol Source Type: research

Adherence to treatment guidelines and survival in older women with early-stage breast cancer in Denmark 2008-2012.
Conclusions: Adherence to treatment according to guidelines decreases with increasing age, mainly for patients aged 80+ years. Our results suggest that surgery is important for the survival of patients aged less than 80 years. PMID: 32364416 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - May 4, 2020 Category: Cancer & Oncology Authors: Vogsen M, Bille C, Jylling AMB, Jensen MB, Ewertz M, Academy for Geriatric Cancer Research (AgeCare) Tags: Acta Oncol Source Type: research

Predictive pharmacogenetic biomarkers for breast cancer recurrence prevention by simvastatin.
Conclusion: Our study provides weak evidence to support the use of genetic variation in ABCB1, SLCO1B1, CYP3A4, and CYP3A5 as biomarkers of breast tumor response to simvastatin. Validation of these findings within adjuvant clinical trials is encouraged. PMID: 32351149 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - April 30, 2020 Category: Cancer & Oncology Authors: Ahern TP, Damkier P, Feddersen S, Kjærsgaard A, Lash TL, Hamilton-Dutoit S, Lythjohan CB, Ejlertsen B, Christiansen PM, Cronin-Fenton DP Tags: Acta Oncol Source Type: research

Leukocyte nadir as a predictive factor for efficacy of adjuvant chemotherapy in breast cancer. Results from the prospective trial SBG 2000-1.
Conclusion: This prospective study confirms that chemotherapy-induced leukopenia is a covariable with outcome in primary breast cancer, even after adjustment for chemotherapy doses. PMID: 32347139 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - April 29, 2020 Category: Cancer & Oncology Authors: Poikonen-Saksela P, Lindman H, Sverrisdottir A, Edlund P, Villman K, Tennvall Nittby L, Cold S, Bechmann T, Stenbygaard L, Ejlertsen B, Andersson M, Blomqvist C, Bergh J, Ahlgren J Tags: Acta Oncol Source Type: research

Results of neoadjuvant chemo(radio)therapy and resection for stage IIIA non-small cell lung cancer in The Netherlands.
Conclusion: In The Netherlands, between 2010 and 2016, 4.5% of patients with stage IIIA NSCLC were selected for treatment with neoadjuvant therapy followed by resection. The 5-year OS in these patients exceeded 50%. However, the outcome might be overestimated due to clinical over staging. PMID: 32347142 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - April 29, 2020 Category: Cancer & Oncology Authors: Joosten PJM, Damhuis RAM, van Diessen JNA, de Langen JA, Belderbos JSA, Smit EF, Klomp HM, Veenhof AAFA, Hartemink KJ Tags: Acta Oncol Source Type: research

Long-term outcome in patients operated with hybrid esophagectomy for esophageal cancer - a cohort study.
Conclusions: In this patient series, HE offered low postoperative mortality and good overall long-term survival. Most survivors maintained good quality of life more than five years post treatment. There was a low rate of serious postoperative complications. PMID: 32324079 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - April 23, 2020 Category: Cancer & Oncology Authors: Hauge T, Amdal CD, Falk RS, Johannessen HO, Johnson E Tags: Acta Oncol Source Type: research

A national study to assess outcomes of definitive chemoradiation regimens in proximal esophageal cancer.
Conclusion: Our study was unable to demonstrate a difference in OS between the CRT regimens, probably related to the relatively small sample size. Based on the superior safety profile, carboplatin and paclitaxel-based CRT regimens are preferred in patients with locally advanced proximal EC. PMID: 32319845 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - April 22, 2020 Category: Cancer & Oncology Authors: de Vos-Geelen J, Hoebers FJP, Geurts SME, Hoeben A, de Greef BTA, Voncken FEM, Bogers JHA, Braam PM, Muijs CKT, de Jong MA, Kasperts N, Rozema T, Jeene PM, Blom GJ, van Dieren JM, Hulshof MCCM, van Laarhoven HWM, Grabsch HI, Lemmens VEPP, Tjan-Heijnen VCG Tags: Acta Oncol Source Type: research

Socioeconomic inequalities in stage-specific breast cancer incidence: a nationwide registry study of 1.1 million young women in Norway, 2000-2015.
Conclusion: Increased breast cancer rates among young high SES women is not just increased detection of small localized tumors, but also increased incidence of tumors with regional spread. The higher incidence of young high SES women is therefore real and not only because of excessive screening. PMID: 32319848 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - April 22, 2020 Category: Cancer & Oncology Authors: Trewin CB, Hjerkind KV, Johansson ALV, Strand BH, Kiserud CE, Ursin G Tags: Acta Oncol Source Type: research

Whole-body diffusion-weighted magnetic resonance imaging for the detection of bone metastases and their prognostic impact in metastatic renal cell carcinoma patients treated with angiogenesis inhibitors.
Abstract Background: Metastatic renal cell carcinoma (mRCC) patients with bone metastases (BM) are at high risk for skeletal related events and have a poorer outcome when treated with vascular endothelial growth factor receptor-tyrosine kinase inhibitors (VEGFR-TKIs). Computed tomography (CT) lacks sensitivity to detect BM in mRCC. We aimed to determine the added value of whole body diffusion-weighted magnetic resonance imaging (WB-DWI/MRI) to CT for the detection of BM in mRCC and to estimate the prognostic impact of the number of BM in mRCC patients treated with VEGFR-TKIs.Material and methods: We conducted a pr...
Source: Acta Oncologica - April 16, 2020 Category: Cancer & Oncology Authors: Beuselinck B, Pans S, Bielen J, De Wever L, Noppe N, Vanderschueren G, De Keyzer F, Baldewijns M, Lerut E, Laenen A, Verbiest A, Roussel E, Albersen M, Vandecaveye V Tags: Acta Oncol Source Type: research

Long-term follow-up on shoulder and arm morbidity in patients treated for early breast cancer.
Conclusion: More than 11 years after breast cancer surgery, the majority of participants complained of one or more subjective symptoms of shoulder and arm morbidity. Objective findings were mild or modest in most cases. During the prolonged follow-up period of 10 years, a worsening in symptoms and objective findings was observed.HIGHLIGHTSShoulder and arm morbidity in relation to breast cancer treatment seems to progress beyond 10 years.The most frequent symptoms were pain, swelling or heaviness of the arm, and decreased shoulder mobility.The objective evaluation showed higher arm volumes and reduced shoulder mobili...
Source: Acta Oncologica - April 14, 2020 Category: Cancer & Oncology Authors: Hauerslev KR, Madsen AH, Overgaard J, Damsgaard TE, Christiansen P Tags: Acta Oncol Source Type: research

Pembrolizumab as first line treatment of Merkel cell carcinoma patients - a case series of patients with various co-morbidities.
ker N PMID: 32285728 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - April 14, 2020 Category: Cancer & Oncology Authors: Bystrup Boyles T, Schødt M, Hendel HW, Krarup-Hansen A, Junker N Tags: Acta Oncol Source Type: research

Two-year toxicity of hypofractionated breast cancer radiotherapy in five fractions.
PMID: 32285729 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - April 14, 2020 Category: Cancer & Oncology Authors: Van Hulle H, Vakaet V, Deckmyn K, Monten C, Paelinck L, Van Greveling A, Post G, Schoepen M, Fonteyne A, Speleers B, Deseyne P, Mareel M, De Neve W, Veldeman L Tags: Acta Oncol Source Type: research

BRAF mutational status as a prognostic marker for survival in malignant melanoma: a systematic review and meta-analysis.
Conclusion: Although there was substantial heterogeneity between the studies, the overall results demonstrated a poorer prognosis and OS in patients harbouring BRAF mutations. Future studies should take this into account when evaluating epidemiological data and treatment effects of new interventions in patients with malignant melanoma. PMID: 32285732 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - April 14, 2020 Category: Cancer & Oncology Authors: Ny L, Hernberg M, Nyakas M, Koivunen J, Oddershede L, Yoon M, Wang X, Guyot P, Geisler J Tags: Acta Oncol Source Type: research

Maternal coping strategies in response to child's oncological diseases in Sri Lanka.
Conclusions: Relaxation and counseling programs to modify less desirable coping strategies are emphasized for mothers who were with cancer children. More researches need to identify coping strategies and its impact on psychological and physical adjustment as well. PMID: 32286131 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - April 14, 2020 Category: Cancer & Oncology Authors: Padeniya RN, Thushari G, Nissanka DH, Shashika C, Munasinghe DH, Aberathne DM, Weerawardena PL, Galgamuwa LS, Kumarasinghe N, Liyanage L Tags: Acta Oncol Source Type: research

Use of primary health care and participation in colorectal cancer screening - a Danish national register-based study.
rg AJ PMID: 32286136 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - April 14, 2020 Category: Cancer & Oncology Authors: Clarke RB, Therkildsen C, Gram MA, Andersen KK, Mørch LS, Tybjerg AJ Tags: Acta Oncol Source Type: research

Prognostic factors of local control and disease free survival in centrally located non-small cell lung cancer treated with stereotactic body radiation therapy.
Abstract Background: Stereotactic body radiation therapy (SBRT) results in high local control (LC) rates in patients with non-small cell lung cancer (NSCLC). For central lung tumors, risk-adapted fractionation schedules are used and underdosage to the Planned Target Volume (PTV) is often accepted to respect the dose constraints of the organs at risk in order to avoid high rates of toxicity. The purpose of this study was to analyze the effect of PTV underdosage and other possible prognostic factors on local- and disease control after SBRT in patients with central lung tumors.Material and Methods: Patients with cent...
Source: Acta Oncologica - April 14, 2020 Category: Cancer & Oncology Authors: Duijm M, van der Voort van Zyp NC, Granton PV, van de Vaart P, Mast ME, Oomen-de Hoop E, Hoogeman MS, Nuyttens JJ Tags: Acta Oncol Source Type: research

Recent clinical evidence on metronomic dosing in controlled clinical trials: a systematic literature review.
Discussion: Most of the studies did not show significantly improved overall survival or progression-free survival. Typically, the metronomic dosing was explored in a maintenance setup and was added to other agents given within normal high doses, whereas no trial was performed challenging metronomic dosing and best supportive care in later treatment lines. Therefore, there is no definite evidence on the efficacy of single metronomic dosing and firm evidence of metronomic dosing is still missing. There is a need for further confirmation of the usefulness of this approach in clinical practice. PMID: 32275176 [PubMed - as...
Source: Acta Oncologica - April 10, 2020 Category: Cancer & Oncology Authors: Wichmann V, Eigeliene N, Saarenheimo J, Jekunen A Tags: Acta Oncol Source Type: research

Expectations to Patient-Reported Outcome (PRO) in Oncology - PRO for a purpose, when and how?
;j GA PMID: 32253960 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - April 7, 2020 Category: Cancer & Oncology Authors: Pappot H, Taarnhøj GA Tags: Acta Oncol Source Type: research

Elderly gynaecological cancer patients at risk for poor end of life care: a population-based study from the Swedish Register of Palliative Care.
Conclusions: EOL care did not meet national quality indicators in this population-based data from Sweden, in particular in the elderly population. Elderly gynaecological cancer patients are at high risk of poorer EOL care without the involvement of specialized palliative care services. Palliative care services need to be implemented across all institutions of EOL care to ensure good and equal care. PMID: 32238040 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - April 2, 2020 Category: Cancer & Oncology Authors: Lindemann K, Martinsson L, Kaasa S, Lindquist D Tags: Acta Oncol Source Type: research

Presentation and management of primary mediastinal large B-cell lymphoma: a retrospective cohort analysis.
PMID: 32233823 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - April 1, 2020 Category: Cancer & Oncology Authors: Eule C, Arora N, Li HC, Sadeghi N Tags: Acta Oncol Source Type: research

Body composition measured by computed tomography is associated with colorectal cancer survival, also in early-stage disease.
Conclusion: In concordance with previous studies, sarcopenia and myosteatosis were associated with decreased cancer-specific survival. The strong association between sarcopenia and poor cancer-specific survival in early-stage disease could have clinical implications for personalizing therapy decisions, including nutritional support. PMID: 32228271 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - March 31, 2020 Category: Cancer & Oncology Authors: Shirdel M, Andersson F, Myte R, Axelsson J, Rutegård M, Blomqvist L, Riklund K, van Guelpen B, Palmqvist R, Gylling B Tags: Acta Oncol Source Type: research

Circulating tumour DNA alterations as biomarkers for head and neck cancer: a systematic review.
Conclusion: We found that increasing the number of ctDNA genetic methylations resulted in an increase in diagnostic sensitivity accuracy. No studies investigating ctDNA mutations included a control group. A combination of multiple human ctDNA gene alterations with viral ctDNA are promising tools for developing a ctDNA biomarker for HNSCC. PMID: 32223478 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - March 30, 2020 Category: Cancer & Oncology Authors: Pall AH, Jakobsen KK, Grønhøj C, von Buchwald C Tags: Acta Oncol Source Type: research

Biological optimization for mediastinal lymphoma radiotherapy - a preliminary study.
Conclusions: We developed an individualized, outcome-optimized planning technique for HL. Some of the resulting plans were substantially different from clinical plans. The results varied depending on how risk models were defined or prioritized. PMID: 32216586 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - March 27, 2020 Category: Cancer & Oncology Authors: Rechner LA, Modiri A, Stick LB, Maraldo MV, Aznar MC, Rice SR, Sawant A, Bentzen SM, Vogelius IR, Specht L Tags: Acta Oncol Source Type: research

Local control by salvage stereotactic body radiotherapy for recurrent/residual hepatocellular carcinoma after other local therapies.
Abstract Background: To clarify local control by salvage stereotactic body radiotherapy (SBRT) for recurrent/residual hepatocellular carcinoma (HCC) compared with initial definitive SBRT for local treatment-naïve HCC.Material and methods: We retrospectively investigated HCC patients that received SBRT between July 2005 and December 2017. We classified HCC tumors as the initial definitive SBRT group (Arm-1; initial definitive SBRT, Arm-2; initial definitive planned SBRT following transarterial chemoembolization (TACE)) and salvage SBRT group (Arm-3; salvage SBRT for recurrent/residual tumors after TACE, Arm-4;...
Source: Acta Oncologica - March 27, 2020 Category: Cancer & Oncology Authors: Kibe Y, Takeda A, Tsurugai Y, Eriguchi T Tags: Acta Oncol Source Type: research

Molecularly matched therapy in the context of sensitivity, resistance, and safety; patient outcomes in end-stage cancer - the MetAction study.
Conclusions: The systematic MetAction approach may point forward to a refined framework for how to interpret the complexity of sensitivity versus resistance and patient safety that resides in tumor sequence data, for the possibly improved outcome of precision cancer medicine in future studies. ClinicalTrials.gov, identifier: NCT02142036. PMID: 32208873 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - March 25, 2020 Category: Cancer & Oncology Authors: Ree AH, Nygaard V, Boye K, Heinrich D, Dueland S, Bergheim IR, Johansen C, Beiske K, Negård A, Lund-Iversen M, Nygaard V, Hovig E, Nakken S, Nasser S, Julsrud L, Reisse CH, Ruud EA, Kristensen VN, Flørenes VA, Geitvik GA, Lingjærde OC, Børresen-Dale A Tags: Acta Oncol Source Type: research

Daily dose to organs at risk predicts acute toxicity in pancreatic stereotactic radiotherapy.
PMID: 32207351 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - March 24, 2020 Category: Cancer & Oncology Authors: Loi M, Magallon-Baro A, Suker M, Van Eijck C, Hoogeman M, Nuyttens JJ Tags: Acta Oncol Source Type: research

Analysis of early respiratory-related mortality after radiation therapy of non-small-cell lung cancer: feasibility of automatic data extraction for dose-response studies.
auml;ck A Abstract Purpose: To examine the feasibility of automatic data extraction from clinical radiation therapy (RT) databases at four hospitals to investigate the impact of mean lung dose (MLD) and age on the risk of early respiratory-related death and early overall death for patients treated with RT for non-small-cell lung cancer (NSCLC).Material and methods: We included adult patients with NSCLC receiving curatively intended RT between 2002 and 2017 at four hospitals. A script was developed to automatically extract RT-related data. The cause of death for patients deceased within 180 days of the start o...
Source: Acta Oncologica - March 23, 2020 Category: Cancer & Oncology Authors: Stervik L, Pettersson N, Scherman J, Behrens CF, Ceberg C, Engelholm S, Gunnarsson K, Hallqvist A, Nyman J, Persson GF, Pøhl M, Wahlstedt I, Vogelius IR, Bäck A Tags: Acta Oncol Source Type: research

Patient-reported outcomes 1 year after oesophageal cancer surgery.
Conclusions: This nationwide, population-based study indicates that symptom burden is high in oesophageal cancer survivors 1 year after surgery. The most common problems are associated with food intake, sleep, fatigue and anxiety. However, less frequent symptoms were sometimes more debilitating for the individual patient. PMID: 32193960 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - March 20, 2020 Category: Cancer & Oncology Authors: Schandl A, Johar A, Anandavadivelan P, Vikström K, Mälberg K, Lagergren P Tags: Acta Oncol Source Type: research

Frequency of discordance in programmed death-ligand 1 (PD-L1) expression between primary tumors and paired distant metastases in advanced cancers: a systematic review and meta-analysis.
Conclusion: Approximately one-third of advanced cancer cases have discordance in PD-L1 expression between primary tumors and paired distant metastases. A more liberal testing of PD-L1 expression in both primary and metastatic tumors is recommended in order to identify patients who may benefit from immune checkpoint blockade treatment. Further research exploring the mechanisms and its impact are warranted. PMID: 32193962 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - March 20, 2020 Category: Cancer & Oncology Authors: Lee CC, Soon YY, Lum JHY, Tan CL, Tey JCS Tags: Acta Oncol Source Type: research