An easily adaptable validated risk score predicts cancer-specific survival in stage II colon cancer.
ring;lgars A, Ristamäki R PMID: 33044880 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - October 12, 2020 Category: Cancer & Oncology Authors: Heervä E, Väliaho V, Salminen T, Nieminen L, Carpelan A, Kurki S, Sundström J, Huhtinen H, Rantala A, Carpén O, Minn H, Österlund P, Ålgars A, Ristamäki R Tags: Acta Oncol Source Type: research

Oncological therapy to Swedish men with metastatic penile cancer 2000-2015.
CONCLUSION: The use of oncological treatment was below recommendations in guidelines but increased during the study period. Treatment was given predominantly to men with c/pN2-3 and M1-disease. Survival was higher among men treated with curative intent; this could be due to patient selection bias. PMID: 33030399 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - October 8, 2020 Category: Cancer & Oncology Authors: Ulvskog E, Drevin L, Persson EK, Lambe M, Kirrander P, Ahlgren J Tags: Acta Oncol Source Type: research

Clinical iterative model development improves knowledge-based plan quality for high-risk prostate cancer with four integrated dose levels.
Abstract BACKGROUND: Manual volumetric modulated arc therapy (VMAT) treatment planning for high-risk prostate cancer receiving whole pelvic radiotherapy (WPRT) with four integrated dose levels is complex and time consuming. We have investigated if the radiotherapy planning process and plan quality can be improved using a well-tuned model developed through a commercial system for knowledge-based planning (KBP). MATERIAL AND METHODS: Treatment plans from 69 patients treated for high-risk prostate cancer with manually planned VMAT were used to develop an initial KBP model (RapidPlan, RP). Prescribed doses were 5...
Source: Acta Oncologica - October 8, 2020 Category: Cancer & Oncology Authors: Hundvin JA, Fjellanger K, Pettersen HES, Nygaard B, Revheim K, Sulen TH, Ekanger C, Hysing LB Tags: Acta Oncol Source Type: research

HE4 in the evaluation of tumor load and prognostic stratification of high grade serous ovarian carcinoma.
Hynninen J Abstract OBJECTIVE: Human epididymis protein 4 (HE4) is a validated, complementary biomarker to cancer antigen 125 (CA125) for high grade serous ovarian carcinoma (HGSC). Currently, there are insufficient data on the utility of longitudinal HE4 measurement during HGSC treatment and follow up. We set to provide a comprehensive analysis on the kinetics and prognostic performance of HE4 with serial measurements during HGSC treatment and follow up. METHODS: This prospective study included 143 patients with advanced HGSC (ClinicalTrials.gov identifier: NCT01276574). Serum CA125 and HE4 were measured at...
Source: Acta Oncologica - October 8, 2020 Category: Cancer & Oncology Authors: Salminen L, Gidwani K, Grènman S, Carpén O, Hietanen S, Pettersson K, Huhtinen K, Hynninen J Tags: Acta Oncol Source Type: research

Management of low-grade cervical cytology in young women. Cohort study from Denmark.
nge E Abstract OBJECTIVE: Cytology findings of atypical squamous cells of unknown significance (ASCUS) or low-grade squamous intraepithelial lesion (LSIL) are common among women under 30, but evidence on best management strategy is insufficient. We therefore investigated how different management strategies used in Denmark influenced biopsy rates and detection of cervical intraepithelial neoplasia (CIN). METHODS: Register-based cohort study including Danish women aged less than 30 years and born 1980-95, with ASCUS/LSIL as their first abnormal cervical cytology in 2008-16. Rates and relative risks (RR) ...
Source: Acta Oncologica - October 8, 2020 Category: Cancer & Oncology Authors: St-Martin G, Thamsborg LH, Andersen B, Christensen J, Ejersbo D, Jochumsen K, Johansen T, Larsen LG, Waldstrøm M, Lynge E Tags: Acta Oncol Source Type: research

Trends in pre-operative needle biopsy use in invasive breast cancer diagnosis: a Dutch nationwide population study.
CONCLUSION: Results suggest that nationwide, clinics prioritise reliability and availability of ER and HER2 status, replacing FNAC by CNB. However, for optimal treatment planning for all patients, availability of pre-operative receptor status warrants further improvement. PMID: 33030998 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - October 8, 2020 Category: Cancer & Oncology Authors: Bulte JP, Simsek D, Bult P, de Wilt JHW, Strobbe LJA Tags: Acta Oncol Source Type: research

Quality of life in patients with cancer during the COVID-19 pandemic - a Danish cross-sectional study (COPICADS).
CONCLUSION: Danish patients with cancer during the COVID-19 pandemic did not have lower scores of QoL and emotional functioning compared to the Danish 'Barometer Study'. However, the study suggests that concerns of contracting COVID-19 was correlated with lower scores of QoL. PMID: 33031010 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - October 8, 2020 Category: Cancer & Oncology Authors: Jeppesen SS, Bentsen KK, Jørgensen TL, Holm HS, Holst-Christensen L, Tarpgaard LS, Dahlrot RH, Eckhoff L Tags: Acta Oncol Source Type: research

Rehabilitation and palliative care for socioeconomically disadvantaged patients with advanced cancer: a scoping review.
CONCLUSION: Existing research within this research field is sparse. Future research should focus more on how best to reach and support socioeconomically disadvantaged people with advanced cancer in community-based rehabilitation and palliative care. PMID: 33021852 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - October 5, 2020 Category: Cancer & Oncology Authors: Sampedro Pilegaard M, Knold Rossau H, Lejsgaard E, Kjer Møller JJ, Jarlbaek L, Dalton SO, la Cour K Tags: Acta Oncol Source Type: research

RBE for proton radiation therapy - a Nordic view in the international perspective.
CONCLUSIONS: The need for collaboration between the clinical proton centres in establishing common platforms and perspectives for treatment planning evaluation and optimisation is highlighted as well as the need of close interaction with the research academic groups that could offer a complementary perspective and actively help developing methods and tools for clinical implementation of the more complex metrics for considering the variable effectiveness of the proton beams. PMID: 33000988 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - September 30, 2020 Category: Cancer & Oncology Authors: Toma-Dasu I, Dasu A, Vestergaard A, Witt Nyström P, Nyström H Tags: Acta Oncol Source Type: research

Reduction of inter-observer contouring variability in daily clinical practice through a retrospective, evidence-based intervention.
CONCLUSION: We detected significant contouring IOV in routine practice using easily accessible retrospective data and successfully decreased IOV in our clinic through a reflective intervention. Continued application of this approach may aid improvements in practice standardization and enhance quality of care. PMID: 32988249 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - September 28, 2020 Category: Cancer & Oncology Authors: Patrick HM, Souhami L, Kildea J Tags: Acta Oncol Source Type: research

Management of meningeal solitary fibrous tumors/hemangiopericytoma; surgery alone or surgery plus postoperative radiotherapy?
CONCLUSION: This retrospective study, investigating postoperative RT in primary localized meningeal SFT patients, suggests that combining RT to surgery in the management of this patient population may reduce the risk for local failures. PMID: 32988268 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - September 28, 2020 Category: Cancer & Oncology Authors: Haas RL, Walraven I, Lecointe-Artzner E, van Houdt WJ, Scholten AN, Strauss D, Schrage Y, Hayes AJ, Raut CP, Fairweather M, Baldini EH, Gronchi A, De Rosa L, Griffin AM, Ferguson PC, Wunder J, van de Sande MAJ, Krol ADG, Skoczylas J, Brandsma D, Doglietto Tags: Acta Oncol Source Type: research

The power of empirical data; lessons from the clinical registry initiatives in Scandinavian cancer care.
CONCLUSIONS: The clinical registry framework provides an empirical basis for evidence-based development of high-quality and equitable cancer care. The registries can be used to follow implementation of new treatment principles and monitor patterns of care across geographical areas and patient groups. At the same time, the lessons learnt suggest that further developments and coordination are needed to utilize the full potential of the registry initiative in cancer care. PMID: 32981417 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - September 25, 2020 Category: Cancer & Oncology Authors: Nilbert M, Thomsen LA, Winther Jensen J, Møller H, Borre M, Widenlou Nordmark A, Lambe M, Brändström H, Kørner H, Møller B, Ursin G Tags: Acta Oncol Source Type: research

A petition for all patients with hidradenitis suppurativa to receive the HPV vaccine.
PMID: 32975480 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - September 24, 2020 Category: Cancer & Oncology Authors: Deutsch A, Cohen SR, Blasiak RC Tags: Acta Oncol Source Type: research

Hypofractionated stereotactic photon radiotherapy of choroidal melanoma: 20-year experience.
CONCLUSION: Hypofractionated stereotactic photon radiotherapy showed a high rate of local tumor control for choroidal melanoma and an acceptable rate of radiogenic side effects. PMID: 32969745 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - September 23, 2020 Category: Cancer & Oncology Authors: Eibenberger K, Dunavoelgyi R, Gleiss A, Sedova A, Georg D, Poetter R, Dieckmann K, Zehetmayer M Tags: Acta Oncol Source Type: research

Combining epigenetic therapy with venetoclax overcomes alemtuzumab resistance in T-cell prolymphocytic leukemia. A case report of a 26-year-old man with a prior history of T-cell acute lymphoblastic leukemia and GI-T lymphoma.
CU PMID: 32970500 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - September 23, 2020 Category: Cancer & Oncology Authors: Andersen MA, Valentin R, Dissing Sjö L, Borgwardt L, Schmiegelow K, Andersen MK, Marvig RL, Yde CW, Niemann CU Tags: Acta Oncol Source Type: research

Metastatic uveal melanoma managed with best supportive care.
TT PMID: 32960119 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - September 21, 2020 Category: Cancer & Oncology Authors: Rantala ES, Hernberg MM, Lundin M, Lundin J, Kivelä TT Tags: Acta Oncol Source Type: research

Adherence to international recommendations in the governance and organisation of Nordic cervical cancer screening programmes.
CONCLUSIONS: The Nordic cervical cancer screening programmes have substantially decreased cancer burden despite not fully adhering to many of the recommendations. The presented gaps in adherence suggest that there is room for improvement in the screening programmes. Establishing clearer governance structures would still increase the ability to manage changes such as implementing HPV testing as the primary screening method or modifying the programme when HPV vaccinated cohorts of women enter the target age for screening. PMID: 32955963 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - September 20, 2020 Category: Cancer & Oncology Authors: Partanen VM, Heinävaara S, Waldstrøm M, Elfström KM, Tropé A, Ágústsson ÁI, Thorsteinsdottir S, Skare GB, Lönnberg S Tags: Acta Oncol Source Type: research

Daily dosimetric variation between image-guided volumetric modulated arc radiotherapy and MR-guided daily adaptive radiotherapy for prostate cancer stereotactic body radiotherapy.
CONCLUSION: MR-guided daily-adaptive SBRT seems a feasible and accurate strategy for treating prostate cancer with ablative doses. IGRT with the use of fiducials provides a comparable level of accuracy and acceptable real-dose distribution over treatment fractions. Future study will provide additional data regarding the tolerability and the clinical outcome of this new technological approach. PMID: 32945701 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - September 17, 2020 Category: Cancer & Oncology Authors: Nicosia L, Sicignano G, Rigo M, Figlia V, Cuccia F, De Simone A, Giaj-Levra N, Mazzola R, Naccarato S, Ricchetti F, Vitale C, Ruggieri R, Alongi F Tags: Acta Oncol Source Type: research

Robust treatment planning of dose painting for prostate cancer based on ADC-to-Gleason score mappings - what is the potential to increase the tumor control probability?
CONCLUSIONS: TCP increases with DPBN plans optimized in a TPS were found more likely with a high precision mapping of image data into dose-responses and a high certainty of the tumor positioning. These findings motivate further development to ensure precise mappings of image data into dose-responses and to ensure a high spatial certainty of the tumor positioning when implementing DPBN clinically. PMID: 32941092 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - September 16, 2020 Category: Cancer & Oncology Authors: Grönlund E, Almhagen E, Johansson S, Traneus E, Nyholm T, Thellenberg C, Ahnesjö A Tags: Acta Oncol Source Type: research

Voluntary wheel running can lead to modulation of immune checkpoint molecule expression.
CONCLUSION: B16 tumors displayed upregulated expression of immune regulatory molecules and decreased tumor growth in response to PA. However, combining PA with PD-1 or PD-L1 blockade did not lead to a further augmented inhibition of tumor growth. PMID: 32935602 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - September 15, 2020 Category: Cancer & Oncology Authors: Bay ML, Unterrainer N, Stagaard R, Pedersen KS, Schauer T, Staffeldt MM, Christensen JF, Hojman P, Pedersen BK, Gehl J Tags: Acta Oncol Source Type: research

Cancer incidence in non-immigrants and immigrants in Norway.
CONCLUSION: National registries should continuously monitor and present cancer incidence stratified on important population subgroups such as country of birth. This can help assess population subgroup specific needs for cancer prevention and treatment, and could eventually help reduce the morbidity and mortality of cancer. PMID: 32930622 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - September 14, 2020 Category: Cancer & Oncology Authors: Hjerkind KV, Larsen IK, Aaserud S, Møller B, Ursin G Tags: Acta Oncol Source Type: research

Education, income and risk of cancer: results from a Norwegian registry-based study.
CONCLUSION: Our findings were consistent with findings from other studies showing that the incidence rate of cancer differs across levels of socioeconomic status. We may need behavioral change campaigns focused on lifestyle changes that lower the risk of cancer and target perhaps to those with lower socioeconomic status. PMID: 32924698 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - September 13, 2020 Category: Cancer & Oncology Authors: Larsen IK, Myklebust TÅ, Babigumira R, Vinberg E, Møller B, Ursin G Tags: Acta Oncol Source Type: research

Health-related quality of life of long-term advanced melanoma survivors treated with anti-CTLA-4 immune checkpoint inhibition compared to matched controls.
Blank CU Abstract BACKGROUND: Checkpoint inhibitors have changed overall survival for patients with advanced melanoma. However, there is a lack of data on health-related quality of life (HRQoL) of long-term advanced melanoma survivors, years after treatment. Therefore, we evaluated HRQoL in long-term advanced melanoma survivors and compared the study outcomes with matched controls without cancer. MATERIAL AND METHODS: Ipilimumab-treated advanced melanoma survivors without evidence of disease and without subsequent systemic therapy for a minimum of two years following last administration of ipilimumab were eli...
Source: Acta Oncologica - September 13, 2020 Category: Cancer & Oncology Authors: Boekhout AH, Rogiers A, Jozwiak K, Boers-Sonderen MJ, van den Eertwegh AJ, Hospers GA, de Groot JWB, Aarts MJB, Kapiteijn E, Ten Tije AJ, Piersma D, Vreugdenhil G, van der Veldt AA, Suijkerbuijk KPM, Rozeman EA, Neyns B, Janssen KJ, van de Poll-Franse LV, Tags: Acta Oncol Source Type: research

Cryptic partial insertion of the RARA gene into the PML gene without reciprocal RARA-PML fusion: a case report and review of literature.
PMID: 32924730 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - September 13, 2020 Category: Cancer & Oncology Authors: Mahmud W, Brown R, Buckingham L, Tira A, Katz DA Tags: Acta Oncol Source Type: research

Natural language processing for automated quantification of bone metastases reported in free-text bone scintigraphy reports.
CONCLUSIONS: NLP has the potential to automate clinical data extraction from free text radiology notes in orthopedics, thereby optimizing the speed, accuracy, and consistency of clinical chart review. Pending external validation, the NLP algorithm developed in this study may be implemented as a means to aid researchers in tackling large amounts of data. PMID: 32924696 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - September 11, 2020 Category: Cancer & Oncology Authors: Groot OQ, Bongers MER, Karhade AV, Kapoor ND, Fenn BP, Kim J, Verlaan JJ, Schwab JH Tags: Acta Oncol Source Type: research

An appraisal of pivotal evaluation designs in validating noninvasive biomarkers for head and neck cancer detection.
PMID: 32924723 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - September 11, 2020 Category: Cancer & Oncology Authors: Adeoye J, Wan CCJ, Thomson P Tags: Acta Oncol Source Type: research

The role of chemotherapy in patients with small cell lung cancer and poor performance status.
Abstract BACKGROUND: There are limited data on the role of chemotherapy in patients with small cell lung cancer (SCLC) and poor performance status (PS). METHODS: This was a retrospective analysis of a prospective observational study in patients with SCLC and PS 3 or 4. We recorded the initial therapy, symptom improvement, response rate, overall survival (OS), and the impact of various factors on OS. RESULTS: From June 2010 to August 2019, we enrolled 234 patients; 185 (79%) with PS 3 and 49 (21%) PS 4. Initial therapy was best supportive care (BSC) in 49 patients (21%), standard full dose chemotherapy in...
Source: Acta Oncologica - September 11, 2020 Category: Cancer & Oncology Authors: Noronha V, Ravind R, Patil VM, Mokal S, Joshi A, Menon N, Kapoor A, Mahajan A, Janu A, Nakti D, Shah L, Shah S, Prabhash K Tags: Acta Oncol Source Type: research

A Nordic-Baltic perspective on indications for proton therapy with strategies for identification of proper patients.
Weber L, Høyer M Abstract The beneficial effects of protons are primarily based on reduction of low to intermediate radiation dose bath to normal tissue surrounding the radiotherapy target volume. Despite promise for reduced long-term toxicity, the percentage of cancer patients treated with proton therapy remains low. This is probably caused by technical improvements in planning and delivery of photon therapy, and by high cost, low availability and lack of high-level evidence on proton therapy. A number of proton treatment facilities are under construction or have recently opened; there are now two operatio...
Source: Acta Oncologica - September 8, 2020 Category: Cancer & Oncology Authors: Brandal P, Bergfeldt K, Aggerholm-Pedersen N, Bäckström G, Kerna I, Gubanski M, Björnlinger K, Evensen ME, Kuddu M, Pettersson E, Brydøy M, Hellebust TP, Dale E, Valdman A, Weber L, Høyer M Tags: Acta Oncol Source Type: research

Thromboembolic events in brain tumour patients on bevacizumab.
PMID: 32897111 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - September 7, 2020 Category: Cancer & Oncology Authors: Singh GK, Menon N, Jadhav MM, Walavalkar R, DSouza H, Roy S, Das S, Srinivas S, Vallathol DH, Patil VM Tags: Acta Oncol Source Type: research

The majority of Danish breast cancer survivors on adjuvant endocrine therapy have clinically relevant sexual dysfunction: a cross-sectional study.
, Jensen AB Abstract BACKGROUND: Impairments in sexual function are common among breast cancer survivors (BCSs), particularly in BCSs receiving adjuvant endocrine therapy (AET). Whether these impairments cause distress, thus qualifying for a more clinically relevant diagnosis of sexual dysfunction (SD), is inadequately described among BCSs and represents an important research gap. Hence, the primary aim of this study was to estimate the prevalence of clinically relevant SD, in this context: impairments with associated distress, and to identify factors associated with SD among BCSs on AET. Secondly, to explore the ...
Source: Acta Oncologica - August 31, 2020 Category: Cancer & Oncology Authors: Fogh M, Højgaard A, Rotbøl CB, Jensen AB Tags: Acta Oncol Source Type: research

Is there a Nordic solution for the 'proton-problem'?
yer M PMID: 32852249 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - August 26, 2020 Category: Cancer & Oncology Authors: Bergfeldt K, Nystrom H, Witt Nystrom P, Høyer M Tags: Acta Oncol Source Type: research

Impact of programmed death-ligand 1 expression on the patients of stage IV non-small cell lung cancer harboring epidermal growth factor receptor mutation: a systematic review and meta-analysis.
Abstract BACKGROUND: To determine the impact of programed death-ligand 1 (PD-L1) expression on progression-free survival (PFS) outcomes in stage IV epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC) treated with first-line EGFR tyrosine kinase inhibitors (TKIs). MATERIAL AND METHODS: We searched biomedical databases for studies comparing PFS outcomes of PD-L1-positive versus (vs) PD-L1-negative tumors. We assessed the methodological quality of eligible studies using ROBINS-I tool. We employed a two-staged meta-analysis approach by reconstructing individual patient data of each ...
Source: Acta Oncologica - August 23, 2020 Category: Cancer & Oncology Authors: Lee CC, Soon YY, Leong CN, Koh WY, Tey J Tags: Acta Oncol Source Type: research

Feasibility and clinical impact of routine molecular testing of gastrointestinal cancers at a tertiary centre with a multi-gene, tumor-agnostic, next generation sequencing panel.
Abstract BACKGROUND: High-throughput sequencing technologies are increasingly used in research but limited data are available on the feasibility and value of these when routinely adopted in clinical practice. MATERIAL AND METHODS: We analyzed all consecutive cancer patients for whom genomic testing by a 48-gene next-generation sequencing (NGS) panel (Truseq Amplicon Cancer Panel, Illumina) was requested as part of standard care in one of the largest Belgian cancer networks between 2014 and 2019. Feasibility of NGS was assessed in all study patients, while the impact of NGS on the decision making was analyzed ...
Source: Acta Oncologica - August 20, 2020 Category: Cancer & Oncology Authors: Bregni G, Sticca T, Camera S, Akin Telli T, Craciun L, Trevisi E, Pretta A, Kehagias P, Leduc S, Senti C, Deleporte A, Vandeputte C, Saad ED, Kerger J, Gil T, Piccart-Gebhart M, Awada A, Demetter P, Larsimont D, Hendlisz A, Aftimos P, Sclafani F Tags: Acta Oncol Source Type: research

Different expression of BRAFV600E, ALK and PD-L1 in melanoma in children and adolescents: a nationwide retrospective study in Finland in 1990-2014.
CONCLUSIONS: Young melanoma patients had more favorable prognosis and a different staining profile for BRAFV600E, ALK, and PD-L1 in primary tumor than reported in adults. SLNB status was not an indicator for survival. BRAFV600E-positive patients have worse prognosis and could benefit from surveillance and treatment similarly to adults. PMID: 32815748 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - August 19, 2020 Category: Cancer & Oncology Authors: Rousi EK, Koskivuo IO, Juteau SM, Talve LAI, Hernberg MM, Vihinen PP, Kähäri VM Tags: Acta Oncol Source Type: research

Drug repositioning in cancer: a role for antihistamines in breast cancer?
;r L PMID: 32811253 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - August 18, 2020 Category: Cancer & Oncology Authors: Nilbert M, Mellemkjær L Tags: Acta Oncol Source Type: research

End-of-life care among patients with pancreatic cancer with or without palliative intervention: a retrospective single-centre study.
vonen O Abstract INTRODUCTION: Palliative care can reduce the symptom burden and may increase the life expectancy for patients with advanced malignancies. The aim of this study was to evaluate the impact of palliative intervention on the treatment procedures for pancreatic cancer patients during their last month of life. MATERIAL AND METHODS: This retrospective single-centre study included adult pancreatic cancer patients who were treated in Turku University Hospital during their last month of life and died between 2011 and 2016. Data were collected from hospital database. Oncological treatments, the number o...
Source: Acta Oncologica - August 18, 2020 Category: Cancer & Oncology Authors: Rautakorpi L, Jyrkkiö S, Löyttyniemi E, Hirvonen O Tags: Acta Oncol Source Type: research

Circulating tumor DNA as a marker of minimal residual disease following local treatment of metastases from colorectal cancer.
CONCLUSION: The presence of ctDNA following local treatment of metastatic CRC is associated with an increased risk of recurrence and a short time to failure. PMID: 32790489 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - August 12, 2020 Category: Cancer & Oncology Authors: Boysen AK, Pallisgaard N, Andersen CSA, Spindler KG Tags: Acta Oncol Source Type: research

Postoperative serum CA19-9, YKL-40, CRP and IL-6 in combination with CEA as prognostic markers for recurrence and survival in colorectal cancer.
CONCLUSION: In radically operated stage II to IV CRC patients who received adjuvant 5-FU-based chemotherapy, a postoperatively elevated CEA alone or in combination with CA19-9, YKL-40, CRP, or IL-6, or a normal CEA combined with an elevated YKL-40 or with an elevated CRP, may indicate patients at high risk of relapse. PMID: 32790589 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - August 12, 2020 Category: Cancer & Oncology Authors: Hermunen K, Soveri LM, Boisen MK, Mustonen HK, Dehlendorff C, Haglund CH, Johansen JS, Osterlund P Tags: Acta Oncol Source Type: research

Efficacy and safety of cyclin dependent kinases 4/6 inhibitors in the treatment of metastatic breast cancer: a real-world experience.
CONCLUSIONS: CDK4/6i administered in a real-world setting exhibits a similar toxicity profile but higher incidence of treatment discontinuation compared to randomized trials. Efficacy of CDK4/6i among patients pretreated with multiple therapy lines is markedly reduced. PMID: 32783667 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - August 11, 2020 Category: Cancer & Oncology Authors: Edman Kessler L, Wiklander O, Hamberg E, Bergh J, Foukakis T, Matikas A Tags: Acta Oncol Source Type: research

Dynamic ctDNA evaluation of a patient with BRAFV600E metastatic melanoma demonstrates the utility of ctDNA for disease monitoring and tumor clonality analysis.
in M PMID: 32772605 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - August 7, 2020 Category: Cancer & Oncology Authors: Vannas C, Bjursten S, Filges S, Fagman H, Ståhlberg A, Levin M Tags: Acta Oncol Source Type: research

Visual decline in pediatric survivors of brain tumors following radiotherapy.
CONCLUSIONS: Visual acuity decline following radiotherapy for intracranial malignancies in children is rare. A dose of approximately 56 GyRBE to 0.1 cm3 results in an approximately 5% risk of visual acuity decline for children with suprasellar or optic pathway tumors. A dose to 0.1 cm3 of 56 GyRBE appears to be safe for children with tumors elsewhere in the brain. PMID: 32762400 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - August 6, 2020 Category: Cancer & Oncology Authors: Bates JE, Indelicato DJ, Morris CG, Rotondo RL, Bradley JA Tags: Acta Oncol Source Type: research

Age is an individual risk factor for not being referred to adjuvant chemotherapy in patients resected for UICC III colorectal cancer: a nationwide cohort study.
r I PMID: 32752903 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - August 4, 2020 Category: Cancer & Oncology Authors: Bojesen RD, Friis M, Gögenur I Tags: Acta Oncol Source Type: research

Variation in adjuvant and early salvage radiotherapy after robot-assisted radical prostatectomy for prostate cancer: a population-based cohort study.
gel B Abstract Purpose: The primary aim of the study was to assess the association between having a radiotherapy (RT) department on-site at the surgical centre and the performed postoperative treatment strategy for prostate cancer (PCa) patients. According to the current international guidelines, adjuvant radiotherapy (ART) or a regular prostate-specific antigen (PSA)-based follow-up with (early) salvage radiotherapy ((e)SRT) if needed is recommended in case of adverse pathological characteristics.Material and methods: Prospective data on consecutive robot-assisted radical prostatectomy (RARP) patients in Belgium ...
Source: Acta Oncologica - July 30, 2020 Category: Cancer & Oncology Authors: Draulans C, Van Damme N, Isebaert S, Everaerts W, Silversmit G, Joniau S, De Meerleer G, Van Eycken E, Haustermans K, Be-RALP: The Belgian RALP consortium, Ameye F, Joniau S, Roumeguère T, Dekuyper P, Quackels T, Van Cleynenbreugel B Tags: Acta Oncol Source Type: research

The effect of omission of adjuvant radiotherapy after neoadjuvant chemotherapy and breast conserving surgery with a pathologic complete response.
Abstract OBJECTIVE(S): Neoadjuvant chemotherapy (NAC) is a standard of care for locally advanced breast cancers. Adjuvant radiotherapy (RT) after NAC is an area of active research. We hypothesize overall survival (OS) is not altered by omitting RT in women with a pathologic complete response (pCR) to NAC after breast conserving survery (BCS). METHODS: Patients from the National Cancer Database who underwent NAC, BCS, and had a pCR were included. Inflammatory disease, 70yo (adjusted OR2.4, 95%CI 1.58-3.65, p 50 miles; AOR 2.02, 95%CI 1.42-2.87, p 
Source: Acta Oncologica - July 26, 2020 Category: Cancer & Oncology Authors: Mandish SF, Gaskins JT, Yusuf MB, Amer YM, Eldredge-Hindy H Tags: Acta Oncol Source Type: research

Reducing uncertainty: motivations and consequences of seeking a second opinion in oncology.
CONCLUSIONS: SOs can yield psychological benefits by reducing patients' uncertainty, but the added medical value remains debatable. Referring oncologists may not be fully aware of their patients' information needs. Patients should be better informed about goals and benefits of SOs to better manage their expectations. More cost-effective ways of optimally providing medically and psychologically valuable SOs need to be explored. PMID: 32702254 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - July 22, 2020 Category: Cancer & Oncology Authors: Lehmann V, Smets EMA, de Jong M, de Vos FYF, Kenter GG, Stouthard JM, Hillen MA Tags: Acta Oncol Source Type: research

Blood natural killer cells during treatment in recurrent ovarian cancer.
sen K Abstract OBJECTIVE: Recent research indicated favorable prognostic impact of intratumoral natural killer (NK) cells in ovarian carcinoma (OC). The role of NK cells during chemotherapy in OC is unknown. We investigated impact of NK cells in OC patients treated with palliative chemotherapy. METHODS: Participants receiving palliative chemotherapy for recurrent OC (N = 72) had prospectively blood samples at baseline and before cycle 2. NK cell counts were quantified by flow cytometry. NK cell activity was measured by the NK Vue® assay, estimating interferon-gamma production. Overall surviv...
Source: Acta Oncologica - July 20, 2020 Category: Cancer & Oncology Authors: Henriksen JR, Nederby L, Donskov F, Waldstrøm M, Adimi P, Jakobsen A, Dahl Steffensen K Tags: Acta Oncol Source Type: research

Risk of late health effects after soft-tissue sarcomas in childhood - a population-based cohort study within the Adult Life after Childhood Cancer in Scandinavia research programme.
CONCLUSIONS: Soft-tissue sarcoma survivors have an increased risk of somatic late effects in 5 out of 10 main diagnostic groups of diseases, and the risk remains increased up to 40 years after cancer diagnosis. Risks were slightly lower for those treated for tumours in the extremities, and radiotherapy increased the risk by more than two-fold. PMID: 32692292 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - July 20, 2020 Category: Cancer & Oncology Authors: Norsker FN, Boschini C, Rechnitzer C, Holmqvist AS, Tryggvadottir L, Madanat-Harjuoja LM, Schrøder H, Scheike TH, Hasle H, Winther JF, Andersen KK, ALiCCS study group Tags: Acta Oncol Source Type: research

Extranodal NK/T-cell lymphoma, nasal type, with extranasal presentation - a case report and a review of the literature.
CONCLUSION: ENKTCL is a highly aggressive disease which may present in extranasal areas. Although the tumors respond to both chemotherapy and radiotherapy, durable complete remissions are very rare. PMID: 32689856 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - July 19, 2020 Category: Cancer & Oncology Authors: Akbar M, Clasen-Linde E, Specht L Tags: Acta Oncol Source Type: research

Ten years of experience with MRI follow-up of testicular cancer stage I: a retrospective study and an MRI protocol with DWI.
CONCLUSIONS: MRI of the retroperitoneum and pelvis constitutes a safe alternative to CT in follow-up of patients with TC stage I with both a high sensitivity and a high specificity. We present a robust MRI protocol with DWI and estimate that MRI follow-up of TC stage I can be easily implemented in most modern radiology departments. Registration: Conducted with permission from the Danish Data Protection Agency (1-16-02-323-16) and the Danish Health Authority. PMID: 32684054 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - July 19, 2020 Category: Cancer & Oncology Authors: Larsen SKA, Agerbæk M, Jurik AG, Pedersen EM Tags: Acta Oncol Source Type: research

Completeness of esophageal cancer diagnosis in the Finnish Cancer Registry and hospital discharge registry, a nationwide study in Finland.
PMID: 32684064 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - July 19, 2020 Category: Cancer & Oncology Authors: Kauppila JH Tags: Acta Oncol Source Type: research