Survival prediction in patients with gynecological cancer irradiated for brain metastases
Acta Oncol. 2024 Apr 21;63:206-212. doi: 10.2340/1651-226X.2023.34899.ABSTRACTBACKGROUND AND PURPOSE: This large population-based, retrospective, single-center study aimed to identify prognostic factors in patients with brain metastases (BM) from gynecological cancers.MATERIAL AND METHODS: One hundred and forty four patients with BM from gynecological cancer treated with radiotherapy (RT) were identified. Primary cancer diagnosis, age, performance status, number of BM, presence of extracranial disease, and type of BM treatment were assessed. Overall survival (OS) was calculated using the Kaplan-Meier method and the Cox pro...
Source: Acta Oncologica - April 22, 2024 Category: Cancer & Oncology Authors: Silje Skjelsvik Os Kjersti Skipar Eva Skovlund Ivar Hompland Taran Paulsen Hellebust Marianne Gr ønlie Guren Kristina Lindemann Esten S øndrol Nakken Source Type: research
Gender Difference in sidE eFfects of ImmuNotherapy: a possible clue to optimize cancEr tReatment (G-DEFINER): study protocol of an observational prospective multicenter study
Acta Oncol. 2024 Apr 21;63:213-219. doi: 10.2340/1651-226X.2024.24179.ABSTRACTBACKGROUND: Immune checkpoint inhibitors (ICIs) have significantly improved outcomes in various cancers. ICI treatment is associated with the incidence of immune-related adverse events (irAEs) which can affect any organ. Data on irAEs occurrence in relation to sex- differentiation and their association with gender-specific factors are limited.AIMS: The primary objective of the G-DEFINER study is to compare the irAEs incidence in female and male patients who undergo ICI treatment. Secondary objectives are: to compare the irAEs incidence in pre- an...
Source: Acta Oncologica - April 22, 2024 Category: Cancer & Oncology Authors: Rosalba Miceli Hanna Eriksson Giuseppe Lo Russo Salvatore Alfieri Maria Moksnes Bjaan æs Filippo Pietrantonio Loris De Cecco Arsela Prelaj Claudia Proto Johan Franz én Deirdre McDonnell Jos é Javier Berenguer Pina Teresa Beninato Laura Mazzeo Patrizia Source Type: research
Increased cancer incidence among patients with hidradenitis suppurativa - a Danish nationwide register study 1977-2017
Acta Oncol. 2024 Apr 21;63:220-228. doi: 10.2340/1651-226X.2024.26182.ABSTRACTBACKGROUND: The chronic, inflammatory skin disease hidradenitis suppurativa (HS) (prevalence: 0.5%-1%, diagnostic delay: 7-10 years) primarily arises in younger adults and frequently coincides with autoimmune comorbidities and unhealthy life-styles (smoking and obesity). These factors are known to increase cancer risk, but despite this, information on cancer occurrence among HS patients is scarce.MATERIALS AND METHODS: A nationwide retrospective register-based study assessing relative risk of cancer - overall and by anatomical site - following HS...
Source: Acta Oncologica - April 22, 2024 Category: Cancer & Oncology Authors: Rune Andersen Klaus Rostgaard Ole Pedersen Gregor Borut Ernst Jemec Henrik Hjalgrim Source Type: research
Survival prediction in patients with gynecological cancer irradiated for brain metastases
Acta Oncol. 2024 Apr 21;63:206-212. doi: 10.2340/1651-226X.2023.34899.ABSTRACTBACKGROUND AND PURPOSE: This large population-based, retrospective, single-center study aimed to identify prognostic factors in patients with brain metastases (BM) from gynecological cancers.MATERIAL AND METHODS: One hundred and forty four patients with BM from gynecological cancer treated with radiotherapy (RT) were identified. Primary cancer diagnosis, age, performance status, number of BM, presence of extracranial disease, and type of BM treatment were assessed. Overall survival (OS) was calculated using the Kaplan-Meier method and the Cox pro...
Source: Acta Oncologica - April 22, 2024 Category: Cancer & Oncology Authors: Silje Skjelsvik Os Kjersti Skipar Eva Skovlund Ivar Hompland Taran Paulsen Hellebust Marianne Gr ønlie Guren Kristina Lindemann Esten S øndrol Nakken Source Type: research
Gender Difference in sidE eFfects of ImmuNotherapy: a possible clue to optimize cancEr tReatment (G-DEFINER): study protocol of an observational prospective multicenter study
Acta Oncol. 2024 Apr 21;63:213-219. doi: 10.2340/1651-226X.2024.24179.ABSTRACTBACKGROUND: Immune checkpoint inhibitors (ICIs) have significantly improved outcomes in various cancers. ICI treatment is associated with the incidence of immune-related adverse events (irAEs) which can affect any organ. Data on irAEs occurrence in relation to sex- differentiation and their association with gender-specific factors are limited.AIMS: The primary objective of the G-DEFINER study is to compare the irAEs incidence in female and male patients who undergo ICI treatment. Secondary objectives are: to compare the irAEs incidence in pre- an...
Source: Acta Oncologica - April 22, 2024 Category: Cancer & Oncology Authors: Rosalba Miceli Hanna Eriksson Giuseppe Lo Russo Salvatore Alfieri Maria Moksnes Bjaan æs Filippo Pietrantonio Loris De Cecco Arsela Prelaj Claudia Proto Johan Franz én Deirdre McDonnell Jos é Javier Berenguer Pina Teresa Beninato Laura Mazzeo Patrizia Source Type: research
Increased cancer incidence among patients with hidradenitis suppurativa - a Danish nationwide register study 1977-2017
Acta Oncol. 2024 Apr 21;63:220-228. doi: 10.2340/1651-226X.2024.26182.ABSTRACTBACKGROUND: The chronic, inflammatory skin disease hidradenitis suppurativa (HS) (prevalence: 0.5%-1%, diagnostic delay: 7-10 years) primarily arises in younger adults and frequently coincides with autoimmune comorbidities and unhealthy life-styles (smoking and obesity). These factors are known to increase cancer risk, but despite this, information on cancer occurrence among HS patients is scarce.MATERIALS AND METHODS: A nationwide retrospective register-based study assessing relative risk of cancer - overall and by anatomical site - following HS...
Source: Acta Oncologica - April 22, 2024 Category: Cancer & Oncology Authors: Rune Andersen Klaus Rostgaard Ole Pedersen Gregor Borut Ernst Jemec Henrik Hjalgrim Source Type: research
First-line Treatment Patterns and Outcomes in Advanced Non-Small Cell Lung Cancer in Sweden: A Population-based Real-world Study with Focus on Immunotherapy
Acta Oncol. 2024 Apr 21;63:198-205. doi: 10.2340/1651-226X.2024.20309.ABSTRACTBACKGROUND AND PURPOSE: The treatment landscape for patients with advanced non-small cell lung cancer (NSCLC) has evolved significantly since the introduction of immunotherapies. We here describe PD-L1 testing rates, treatment patterns, and real-world outcomes for PD-(L)1 inhibitors in Sweden.MATERIALS AND METHODS: Data were obtained from the Swedish National Lung Cancer Registry for patients with advanced NSCLC and Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0-2 who initiated first-line -systemic treatment from 01 April 201...
Source: Acta Oncologica - April 21, 2024 Category: Cancer & Oncology Authors: Gunnar Wagenius Anders Vikstr öm Anders Berglund Stina Salomonsson Goran Bencina Xiaohan Hu Dana Chirovsky Hans Brunnstr öm Source Type: research
Primary splenic angiosarcoma: a case series of a rare oncological entity and diagnostic challenge
Acta Oncol. 2024 Apr 15;63:192-197. doi: 10.2340/1651-226X.2023.35412.ABSTRACTBACKGROUND AND PURPOSE: Primary angiosarcoma of the spleen (PAS), an exceptionally rare and aggressive neoplasm with high metastatic risk (70%-85%), is frequently diagnosed in an advanced or metastatic stage. It presents diagnostic challenges due to its nonspecific symptomatology and resemblance to benign vascular lesions in various imaging modalities.PATIENTS AND METHODS: This case series aims to clarify the diagnostic difficulties by comparing imaging characteristics (CT-scan, MRI, and [18F]FDG-PET/CT) as well as pathological findings of three ...
Source: Acta Oncologica - April 15, 2024 Category: Cancer & Oncology Authors: Iris Dirven Philippe Leclercq Lionel D'Hondt Valentine Delmotte Pierre Lefesvre Hendrik Reynaert Frederik Vandenbroucke Magali Surmont Source Type: research
Primary splenic angiosarcoma: a case series of a rare oncological entity and diagnostic challenge
Acta Oncol. 2024 Apr 15;63:192-197. doi: 10.2340/1651-226X.2023.35412.ABSTRACTBACKGROUND AND PURPOSE: Primary angiosarcoma of the spleen (PAS), an exceptionally rare and aggressive neoplasm with high metastatic risk (70%-85%), is frequently diagnosed in an advanced or metastatic stage. It presents diagnostic challenges due to its nonspecific symptomatology and resemblance to benign vascular lesions in various imaging modalities.PATIENTS AND METHODS: This case series aims to clarify the diagnostic difficulties by comparing imaging characteristics (CT-scan, MRI, and [18F]FDG-PET/CT) as well as pathological findings of three ...
Source: Acta Oncologica - April 15, 2024 Category: Cancer & Oncology Authors: Iris Dirven Philippe Leclercq Lionel D'Hondt Valentine Delmotte Pierre Lefesvre Hendrik Reynaert Frederik Vandenbroucke Magali Surmont Source Type: research
Primary splenic angiosarcoma: a case series of a rare oncological entity and diagnostic challenge
Acta Oncol. 2024 Apr 15;63:192-197. doi: 10.2340/1651-226X.2023.35412.ABSTRACTBACKGROUND AND PURPOSE: Primary angiosarcoma of the spleen (PAS), an exceptionally rare and aggressive neoplasm with high metastatic risk (70%-85%), is frequently diagnosed in an advanced or metastatic stage. It presents diagnostic challenges due to its nonspecific symptomatology and resemblance to benign vascular lesions in various imaging modalities.PATIENTS AND METHODS: This case series aims to clarify the diagnostic difficulties by comparing imaging characteristics (CT-scan, MRI, and [18F]FDG-PET/CT) as well as pathological findings of three ...
Source: Acta Oncologica - April 15, 2024 Category: Cancer & Oncology Authors: Iris Dirven Philippe Leclercq Lionel D'Hondt Valentine Delmotte Pierre Lefesvre Hendrik Reynaert Frederik Vandenbroucke Magali Surmont Source Type: research
Reducing renal function assessment prior to platinum-based chemotherapy: a real-world evaluation
Acta Oncol. 2024 Apr 10;63:169-174. doi: 10.2340/1651-226X.2024.23960.ABSTRACTBACKGROUND: Platinum-based chemotherapy, a widely used backbone of systemic cytotoxic anticancer treatment, is associated with nephrotoxicity. Currently, renal function is generally assessed prior to each administration of cisplatin or carboplatin, but there is no guideline regarding the frequency of renal function determination.OBJECTIVE: The primary objective was to determine the median time to a clinically relevant dosage adjustment (>10%) due to change in renal function in patients treated with cisplatin and carboplatin. Secondly, variable...
Source: Acta Oncologica - April 10, 2024 Category: Cancer & Oncology Authors: Suzanne Van der Gaag Mariette Labots Eleonora L Swart Mirjam Crul Source Type: research
Is the risk of ischemic heart disease in women after radiotherapy for breast cancer nowadays still (linearly) associated with the mean heart dose?
Acta Oncol. 2024 Apr 10;63:175-178. doi: 10.2340/1651-226X.2024.34751.NO ABSTRACTPMID:38597665 | DOI:10.2340/1651-226X.2024.34751 (Source: Acta Oncologica)
Source: Acta Oncologica - April 10, 2024 Category: Cancer & Oncology Authors: Henk Struikmans Anna Petoukhova Joop H M Schreur Mirjam E Mast Philip M Poortmans Source Type: research
Have the recent advancements in cancer therapy and survival benefitted patients of all age groups across the Nordic countries? NORDCAN survival analyses 2002-2021
Acta Oncol. 2024 Apr 10;63:179-191. doi: 10.2340/1651-226X.2024.35094.ABSTRACTBACKGROUND: Since the early 2000s, overall and site-specific cancer survival have improved substantially in the Nordic countries. We evaluated whether the improvements have been similar across countries, major cancer types, and age groups.MATERIAL AND METHODS: Using population-based data from the five Nordic cancer registries recorded in the NORDCAN database, we included a cohort of 1,525,854 men and 1,378,470 women diagnosed with cancer (except non-melanoma skin cancer) during 2002-2021, and followed for death until 2021. We estimated 5-year rel...
Source: Acta Oncologica - April 10, 2024 Category: Cancer & Oncology Authors: Anna L V Johansson Simon M K ønig Siri Lar ønningen Gerda Engholm Niels Kroman Karri Sepp ä Nea Malila Bjarni Á Steig Eva Maria Gudmundsd óttir El ínborg J Ólafsdóttir Frida E Lundberg Therese M-L Andersson Paul C Lambert Mats Lambe David Petterss Source Type: research
Reducing renal function assessment prior to platinum-based chemotherapy: a real-world evaluation
Acta Oncol. 2024 Apr 10;63:169-174. doi: 10.2340/1651-226X.2024.23960.ABSTRACTBACKGROUND: Platinum-based chemotherapy, a widely used backbone of systemic cytotoxic anticancer treatment, is associated with nephrotoxicity. Currently, renal function is generally assessed prior to each administration of cisplatin or carboplatin, but there is no guideline regarding the frequency of renal function determination.OBJECTIVE: The primary objective was to determine the median time to a clinically relevant dosage adjustment (>10%) due to change in renal function in patients treated with cisplatin and carboplatin. Secondly, variable...
Source: Acta Oncologica - April 10, 2024 Category: Cancer & Oncology Authors: Suzanne Van der Gaag Mariette Labots Eleonora L Swart Mirjam Crul Source Type: research
Is the risk of ischemic heart disease in women after radiotherapy for breast cancer nowadays still (linearly) associated with the mean heart dose?
Acta Oncol. 2024 Apr 10;63:175-178. doi: 10.2340/1651-226X.2024.34751.NO ABSTRACTPMID:38597665 | DOI:10.2340/1651-226X.2024.34751 (Source: Acta Oncologica)
Source: Acta Oncologica - April 10, 2024 Category: Cancer & Oncology Authors: Henk Struikmans Anna Petoukhova Joop H M Schreur Mirjam E Mast Philip M Poortmans Source Type: research
