Expression of survivin does not appear to influence breast cancer recurrence risk.
sh TL Abstract BACKGROUND: Survivin is an inhibitor of apoptosis, and its expression associates with poor outcomes in multiple cancers. It may be a therapeutic target due to its unique expression in cancer cells. METHODS: We estimated the association between nuclear and cytoplasmic survivin expression in primary tumors and breast cancer recurrence. In this case-control study, we included women age 35-69, diagnosed with stage I-III breast cancer between 1985 and 2001, and registered with the Danish Breast Cancer Group. We identified 541 patients with breast cancer recurrence with estrogen receptor-positive dis...
Source: Acta Oncologica - October 23, 2018 Category: Cancer & Oncology Authors: Collin LJ, Cronin-Fenton DP, Ahern TP, Christensen KB, Damkier P, Hamilton-Dutoit S, Kjaersgaard A, Lauridsen KL, Yacoub R, Christiansen P, Sørensen HT, Lash TL Tags: Acta Oncol Source Type: research

Cancer-related distress in unselected women with newly diagnosed breast or ovarian cancer undergoing BRCA1/2 testing without pretest genetic counseling.
CONCLUSIONS: Women having genetic testing shortly after a diagnosis of breast or ovarian cancer had a moderate mean level of cancer-related distress, which decreased with time. Health personnel offering genetic testing to newly diagnosed women with breast or ovarian cancer should be aware of the potential predictors for increased cancer-related distress identified in this study: younger age, less perceived social support, higher levels of decisional conflict regarding genetic testing, and living with a partner. PMID: 30334464 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - October 18, 2018 Category: Cancer & Oncology Authors: Høberg-Vetti H, Eide GE, Siglen E, Listøl W, Haavind MT, Hoogerbrugge N, Bjorvatn C Tags: Acta Oncol Source Type: research

Occupational variation in bladder cancer in Nordic males adjusted with approximated smoking prevalence.
CONCLUSIONS: Smoking is a strong risk factor for bladder cancer but there may also be other factors in some specific occupations in addition to smoking. The occupational variation in risk of bladder cancer is small when adjusted for smoking, but risk increasing factors are indicated in some occupations. PMID: 30320536 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - October 15, 2018 Category: Cancer & Oncology Authors: Hadkhale K, Martinsen JI, Weiderpass E, Kjærheim K, Sparén P, Tryggvadóttir L, Lynge E, Pukkala E Tags: Acta Oncol Source Type: research

Automatic segmentation of cardiac substructures from noncontrast CT images: accurate enough for dosimetric analysis?
Abstract PURPOSE: We evaluated the feasibility of using an automatic segmentation tool to delineate cardiac substructures from noncontrast computed tomography (CT) images for cardiac dosimetry and toxicity analyses for patients with nonsmall cell lung cancer (NSCLC) after radiotherapy. MATERIAL AND METHODS: We used an in-house developed multi-atlas segmentation tool to delineate 11cardiac substructures, including the whole heart, four heart chambers, and six greater vessels, automatically from the averaged 4D-CT planning images of 49 patients with NSCLC. Two experienced radiation oncologists edited the auto-s...
Source: Acta Oncologica - October 11, 2018 Category: Cancer & Oncology Authors: Luo Y, Xu Y, Liao Z, Gomez D, Wang J, Jiang W, Zhou R, Williamson R, Court LE, Yang J Tags: Acta Oncol Source Type: research

Anterior resection for rectal cancer in Sweden: validation of a registry-based method to determine long-term stoma outcome.
CONCLUSION: Using data from two national registries to determine long-term stoma outcome after anterior resection for rectal cancer proved to be reliable in comparison to chart review. Permanent stoma prevalence after such surgery remains at a significant level, while stoma outcomes vary substantially between different healthcare regions in Sweden. PMID: 30306825 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - October 11, 2018 Category: Cancer & Oncology Authors: Holmgren K, Haapamäki MM, Matthiessen P, Rutegård J, Rutegård M Tags: Acta Oncol Source Type: research

Adaptive radiotherapy for head and neck cancer.
CONCLUSION: ART may decrease toxicity and improve local control for locally advanced HNC. However, randomized trials are necessary to demonstrate the benefit of ART before using the technique in routine practice. PMID: 30289291 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - October 5, 2018 Category: Cancer & Oncology Authors: Castelli J, Simon A, Lafond C, Perichon N, Rigaud B, Chajon E, De Bari B, Ozsahin M, Bourhis J, de Crevoisier R Tags: Acta Oncol Source Type: research

Long-term quality of life after comprehensive surgical staging of high-risk endometrial cancer - results from the RASHEC trial.
CONCLUSION: Overall, laparotomy and robot-assisted surgery conferred similar HRQoL 12 months after comprehensive staging for high-risk EC. PMID: 30289327 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - October 5, 2018 Category: Cancer & Oncology Authors: Salehi S, Brandberg Y, Åvall-Lundqvist E, Suzuki C, Johansson H, Legerstam B, Falconer H Tags: Acta Oncol Source Type: research

Density override in treatment planning to mitigate the dosimetric effect induced by gastrointestinal gas in esophageal cancer radiation therapy.
CONCLUSIONS: The variation in gas volume during the treatment course can result in clinically undesired underdose or overdose. The DO-based plan-selection strategy can effectively mitigate the gas-induced underdose and minimize the overdose for esophageal cancer RT. PMID: 30289340 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - October 5, 2018 Category: Cancer & Oncology Authors: Jin P, Crama KF, Visser J, van Wieringen N, Bel A, Hulshof MCCM, Alderliesten T Tags: Acta Oncol Source Type: research

Stereotactic body radiation therapy for mediastinal lymph node metastases: how do we fly in a 'no-fly zone'?
CONCLUSIONS: SBRT can be considered as a safe treatment option for selected patients with oligo-metastases/recurrences in the NFZ, if strict dose/volume constraints are applied. PMID: 30280618 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - October 3, 2018 Category: Cancer & Oncology Authors: Alicja Jereczek-Fossa B, Muto M, Durante S, Ferrari A, Piperno G, Fodor C, Comi S, Ricotti R, Garibaldi C, Dicuonzo S, Mazza S, Golino F, Spaggiari L, De Marinis F, Orecchia R, Ciardo D, Fossati P Tags: Acta Oncol Source Type: research

Disparities in colorectal cancer between Northern and SouthernSweden - a report from the new RISK North database.
uist BN Abstract BACKGROUND: Geographic cancer health disparities have been reported in Sweden. The disparities are not fully understood, but may be attributed to differences in exposure to risk factors as well as differences in health care, socioeconomics and demography. The aim of this study was to describe the new nationwide population based RISK North database and its potential by analysing health disparities in colorectal cancer between Northern and Southern Sweden. METHODS: Cancer-specific data from the National Cancer Quality Registers for colorectal, gastric and oesophageal cancer and brain tumours we...
Source: Acta Oncologica - October 3, 2018 Category: Cancer & Oncology Authors: Sjöström O, Silander G, Syk I, Henriksson R, Melin B, Hellquist BN Tags: Acta Oncol Source Type: research

National practice patterns of proton versus photon therapy in the treatment of adult patients with primary brain tumors in the United States.
Abstract OBJECTIVES: To examine patterns of care associated with the administration of proton versus photon therapy for adult patients with primary brain tumors in a large national cohort from the United States. METHODS: The National Cancer Database (NCDB) was queried for newly diagnosed primary brain tumors (2004-2014) in adult patients aged 18 and older receiving proton or photon radiotherapy. Clinical features, patient demographics and treatment parameters were extracted. Differences between groups were assessed using multivariable logistic regression analysis. RESULTS: In total, 73,073 patients were ...
Source: Acta Oncologica - October 3, 2018 Category: Cancer & Oncology Authors: Ryckman JM, Ganesan V, Kusi Appiah A, Zhang C, Verma V Tags: Acta Oncol Source Type: research

Re-irradiation for painful bone metastases using stereotactic body radiotherapy.
CONCLUSIONS: Re-irradiation SBRT has potential to achieve good response and long-term pain control for painful bone metastases. Prospective analysis is necessary to confirm the safety and efficacy of SBRT as re-irradiation. PMID: 30280622 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - October 3, 2018 Category: Cancer & Oncology Authors: Ogawa H, Ito K, Shimizuguchi T, Furuya T, Nihei K, Karasawa K Tags: Acta Oncol Source Type: research

Dose painting for re-irradiation of head and neck cancer.
CONCLUSIONS: Our proposed DPBC could be straightforwardly implemented and all plans met the objectives. Re-irradiation of HNC with DPBC may increase tumor control without more side effects compared to conventional radiotherapy. PMID: 30280623 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - October 3, 2018 Category: Cancer & Oncology Authors: Skjøtskift T, Evensen ME, Furre T, Moan JM, Amdal CD, Bogsrud TV, Malinen E, Dale E Tags: Acta Oncol Source Type: research

Increasing kidney cancer incidence and survival in Estonia: role of age and stage.
CONCLUSION: Estonia is currently among countries with the highest incidence of kidney cancer. The results suggest a combined effect of changing risk profiles in successive birth cohorts and increasing diagnostic activity around 1990. Large survival increase can mostly be attributed to earlier detection, but improved diagnosis and treatment have probably influenced stage-specific survival. High proportion of tumors with unspecified morphology and those with unknown stage among the elderly warrants further investigation of diagnostic and treatment practices. PMID: 30280624 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - October 3, 2018 Category: Cancer & Oncology Authors: Innos K, Sepp T, Baburin A, Kotsar A, Lang K, Padrik P, Aareleid T Tags: Acta Oncol Source Type: research

Frailty status but not age predicts complications in elderly cancer patients: a follow-up study.
d EMS Abstract OBJECTIVES: The purposes were to investigate the health status of elderly cancer patients by comprehensive geriatric assessment (CGA) and to compare the complications with respect to baseline CGA and to evaluate the need for geriatric interventions in an elderly cancer patients' population. MATERIAL: Patients aged ≥70 years with lung cancer (LC), cancer of the head and neck (HNC), colorectal cancer (CRC), or upper gastro-intestinal cancer (UGIC) are referred to the Department of Oncology for cancer treatment. METHODS: CGA was performed prior to cancer treatment and addressed the fo...
Source: Acta Oncologica - October 3, 2018 Category: Cancer & Oncology Authors: Ørum M, Gregersen M, Jensen K, Meldgaard P, Damsgaard EMS Tags: Acta Oncol Source Type: research

Comparative treatment planning study for mediastinal Hodgkin's lymphoma: impact on normal tissue dose using deep inspiration breath hold proton and photon therapy.
CONCLUSIONS: The majority of patients benefited from treatment in DIBH, however, the impact on the normal tissue dose was highly individual and therefore comparative treatment planning is encouraged. The lowest OAR doses were generally observed for IMPT in combination with DIBH. PMID: 30280626 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - October 3, 2018 Category: Cancer & Oncology Authors: Edvardsson A, Kügele M, Alkner S, Enmark M, Nilsson J, Kristensen I, Kjellén E, Engelholm S, Ceberg S Tags: Acta Oncol Source Type: research

Caregivers of patients receiving long-term treatment with a tyrosine kinase inhibitor (TKI) for gastrointestinal stromal tumour (GIST): a cross-sectional assessment of their distress and burden.
CONCLUSIONS: Caregivers of the patients with GIST treated with TKI are managing well. There is a small, vulnerable group of caregivers with high levels of burden and/or distress, show more health-related problems, both physical and mental, and require adequate support. PMID: 30280630 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - October 3, 2018 Category: Cancer & Oncology Authors: Langenberg SMCH, Reyners AKL, Wymenga ANM, Sieling GCM, Veldhoven CMM, van Herpen CML, Prins JB, van der Graaf WTA Tags: Acta Oncol Source Type: research

Simulated dosimetric impact of online replanning for stereotactic body radiation therapy of lymph node oligometastases on the 1.5T MR-linac.
CONCLUSION: The use of online replanning based on the actual anatomy as seen on repeated MRI compared to online position correction for lymph node oligometastases SBRT gives beneficial dosimetric outcomes and reduces the amount of unplanned violations of dose constraints. PMID: 30280631 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - October 3, 2018 Category: Cancer & Oncology Authors: Winkel D, Kroon PS, Werensteijn-Honingh AM, Bol GH, Raaymakers BW, Jürgenliemk-Schulz IM Tags: Acta Oncol Source Type: research

Survival and prognostic factors of pulmonary oligometastases treated with stereotactic body radiotherapy.
In this study, 327 inoperable pulmonary oligometastases in 206 patients were treated with SBRT from the year 2005 to 2015. Primary sites of pulmonary oligometastases included colorectal carcinoma (n = 118), lung carcinoma (n = 36), melanoma (n = 11), sarcoma (n = 10), breast carcinoma (n = 7), and other tumors sites (n = 24). Median follow-up was 26 months. Median survival was 33 months. The 2-year and 5-year OS rates were 63% and 30%, respectively. On univariate analysis synchronous oligometastases (HR 0.59) and colorectal primar...
Source: Acta Oncologica - October 3, 2018 Category: Cancer & Oncology Authors: Sharma A, Duijm M, Oomen-de Hoop E, Aerts JG, Verhoef C, Hoogeman M, Nuyttens JJ Tags: Acta Oncol Source Type: research

Impact of histological subtype on treatment outcomes in locally advanced rectal adenocarcinoma treated with neoadjuvant chemoradiation.
PMID: 30264625 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - September 28, 2018 Category: Cancer & Oncology Authors: Shinde RS, Katdare N, An N, Bhamre R, Desouza A, Ostwal V, Engineer R, Saklani A Tags: Acta Oncol Source Type: research

Precision of T2 TSE MRI-CT-image fusions based on gold fiducials and repetitive T2 TSE MRI-MRI-fusions for adaptive IGRT of prostate cancer by using phantom and patient data.
;ller AC Abstract INTRODUCTION: To increase precision of radiation treatment (RT) delivery in prostate cancer, MRI-based RT as well as the use of fiducials like gold markers (GMs) have shown promising results. Their combined use is currently under investigation in clinical trials. Here, we aimed to evaluate a workflow of image registration based on GMs between CT and MRI as well as weekly MRI-MRI adaption based on T2 TSE sequence. MATERIAL AND METHODS: A gel-phantom with two inserted GMs was scanned with CT and three different MR-scanners of 1.5 and 3 T (T2 TSE and T1 VIBE-Dixon, isotropic, voxel size 2&thins...
Source: Acta Oncologica - September 28, 2018 Category: Cancer & Oncology Authors: Wegener D, Zips D, Thorwarth D, Weiß J, Othman AE, Grosse U, Notohamiprodjo M, Nikolaou K, Müller AC Tags: Acta Oncol Source Type: research

Dosimetric comparison of advanced radiotherapy approaches using photon techniques and particle therapy in the postoperative management of thymoma.
CONCLUSIONS: Particle radiotherapy (PRT, CIRT) showed superior OAR sparing and optimal target volume coverage. The observed dosimetric advantages are expected to reduce toxicity rates. However, their clinical impact must be investigated prospectively. PMID: 30264630 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - September 28, 2018 Category: Cancer & Oncology Authors: Haefner MF, Verma V, Bougatf N, Mielke T, Tonndorf-Martini E, König L, Rwigema JM, Simone Nd CB, Uhlmann L, Eichhorn F, Winter H, Grosch H, Haberer T, Herfarth K, Debus J, Rieken S Tags: Acta Oncol Source Type: research

Fear and forget: how anxiety impacts information recall in newly diagnosed cancer patients visiting a fast-track clinic.
CONCLUSION: High levels of anxiety after receiving a cancer diagnosis negatively influence how much information patients remember after visiting a one-day fast-track clinic. This calls for interventions that may reduce patients' anxiety as much as reasonably possible and support patients' information recall. Researchers, practitioners, and hospitals are encouraged to continue exploring ways to optimize information provision to cancer patients in current modern healthcare. PMID: 30264632 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - September 28, 2018 Category: Cancer & Oncology Authors: Nguyen MH, Smets EMA, Bol N, Bronner MB, Tytgat KMAJ, Loos EF, van Weert JCM Tags: Acta Oncol Source Type: research

Subsequent risk of cancer among women with a history of placental abruption.
CONCLUSIONS: Overall, the risk of lung cancer was increased, and the risk of breast cancer decreased, in women with a history of placental abruption. These observations can be explained to some extent by risk factors or risk markers for placental abruption. The increased risk of thyroid cancer may be explained by surveillance bias. PMID: 30264633 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - September 28, 2018 Category: Cancer & Oncology Authors: Riihimäki O, Tikkanen M, Melin J, Andersson S, Metsäranta M, Nuutila M, Gissler M, Paavonen J, Pukkala E Tags: Acta Oncol Source Type: research

Shared decision making plus early palliative care-implications for use in clinical decision making.
PMID: 30264634 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - September 28, 2018 Category: Cancer & Oncology Authors: Vreugdenhil G Tags: Acta Oncol Source Type: research

A comparison of conventional and dynamic radiotherapy planning techniques for early-stage breast cancer utilizing deep inspiration breath-hold.
CONCLUSION: tIMRT and 3D-CRT with DIBH are better techniques for sparing heart tissue and other organs at risk without compromising target coverage in early-stage breast cancer irradiation compared to VMAT. PMID: 30264635 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - September 28, 2018 Category: Cancer & Oncology Authors: Vikström J, Hjelstuen MH, Wasbø E, Mjaaland I, Dybvik KI Tags: Acta Oncol Source Type: research

Comorbidity of distress experienced by parents of childhood cancer survivors points to the importance of understanding transdiagnostic cognitive-affective mechanisms.
PMID: 30264637 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - September 28, 2018 Category: Cancer & Oncology Authors: Vetsch J, McGill BC, Sansom-Daly UM, Hetherington K, Ellis SJ, Marshall KH, Wakefield CE Tags: Acta Oncol Source Type: research

Late gastrointestinal toxicity after radiotherapy for anal cancer: a systematic literature review.
CONCLUSION: Late gastrointestinal toxicities are common with severe toxicity seen in one-third of the patients. These symptoms significantly impact on patients' quality of life. Prospective studies with control groups are needed to elucidate long-term toxicity. PMID: 30264638 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - September 28, 2018 Category: Cancer & Oncology Authors: Pan YB, Maeda Y, Wilson A, Glynne-Jones R, Vaizey CJ Tags: Acta Oncol Source Type: research

Continuation of trastuzumab beyond progression in HER2-positive advanced esophagogastric cancer: a meta-analysis.
Abstract INTRODUCTION: After progression on first-line trastuzumab-based therapy, no HER2-targeted agent is available for patients with HER2-positive esophagogastric cancer. However, continuation of trastuzumab after progression is an established strategy in HER2-positive breast cancer. We conducted a meta-analysis to investigate whether continuation of trastuzumab beyond first-line therapy in combination with chemotherapy is more effective compared to chemotherapy-alone. METHODS: PubMed, EMBASE, CENTRAL and meeting abstracts from ASCO and ESMO were searched up to June 2018 for studies (any design) investigat...
Source: Acta Oncologica - September 28, 2018 Category: Cancer & Oncology Authors: Ter Veer E, van den Ende T, Creemers A, de Waal L, van Oijen MGH, van Laarhoven HWM Tags: Acta Oncol Source Type: research

Association of the location of pancreatic ductal adenocarcinoma (head, body, tail) with tumor stage, treatment, and survival: a population-based analysis.
Abstract BACKGROUND: The association between pancreatic ductal adenocarcinoma (PDAC) location (head, body, tail) and tumor stage, treatment and overall survival (OS) is unclear. METHODS: Patients with PDAC diagnosed between 2005 and 2015 were included from the population-based Netherlands Cancer Registry. Patient, tumor and treatment characteristics were compared with the tumor locations. Multivariable logistic and Cox regression analyses were used. RESULTS: Overall, 19,023 patients were included. PDAC locations were 13,451 (71%) head, 2429 (13%) body and 3143 (16%) tail. Differences were found regarding...
Source: Acta Oncologica - September 28, 2018 Category: Cancer & Oncology Authors: van Erning FN, Mackay TM, van der Geest LGM, Groot Koerkamp B, van Laarhoven HWM, Bonsing BA, Wilmink JW, van Santvoort HC, de Vos-Geelen J, van Eijck CHJ, Busch OR, Lemmens VE, Besselink MG, Dutch Pancreatic Cancer Group Tags: Acta Oncol Source Type: research

Bone sarcoma during pregnancy: an example of personalized multidisciplinary care.
PMID: 30264644 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - September 28, 2018 Category: Cancer & Oncology Authors: Weidema M, Kaal S, de Jong L, van Erp N, Jansen R, Schreuder B, Heidema W, van der Graaf W, Desar I Tags: Acta Oncol Source Type: research

KRAS mutation status, comorbidity, and mortality in patients with metastatic colorectal cancer in Denmark.
Ehrenstein V PMID: 30264648 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - September 28, 2018 Category: Cancer & Oncology Authors: Ording AG, Öztürk B, Spindler KG, Sørensen HT, McCusker M, Ehrenstein V Tags: Acta Oncol Source Type: research

Pazopanib in relapsed osteosarcoma patients: report on 15 cases.
PMID: 30207179 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - September 12, 2018 Category: Cancer & Oncology Authors: Longhi A, Paioli A, Palmerini E, Cesari M, Abate ME, Setola E, Spinnato P, Donati D, Hompland I, Boye K Tags: Acta Oncol Source Type: research

The effect of colorectal cancer screening on health status in a survey study.
CONCLUSIONS: CRC screening did not have any effect on health status measured using self-rated health, healthiness of diet, and physical fitness. Thus, screening for colorectal cancer can be recommended as a health policy. PMID: 30198365 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - September 10, 2018 Category: Cancer & Oncology Authors: Jäntti M, Heinävaara S, Malila N, Sarkeala T Tags: Acta Oncol Source Type: research

Risk factors and patterns of local recurrence in T3 rectal cancer treated with short-course hyperfractionated accelerated chemoradiotherapy with delayed surgery.
PMID: 30169985 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - August 31, 2018 Category: Cancer & Oncology Authors: Beppu N, Okamoto R, Nakamoto Y, Kimura F, Ikeda M, Tomita N, Yanagi H, Yamanaka N Tags: Acta Oncol Source Type: research

Early death in Danish stage I lung cancer patients: a population-based case study.
Abstract OBJECTIVE: Clinical stage (c-stage) at diagnosis is the most significant prognostic marker for patients with cancer, where 1- and 5-year survival rates as main landmarks when assessing outcomes. This is a population-based case study of Danish c-stage I lung cancer patients who were considered candidates for curative therapy and then died within 1 year after diagnosis (cases). Cases were identified in the Danish Lung Cancer Register (DLCR), and medical records were used to retrieve treatment details and cause of death (CoD). Our aims were, if possible, to identify and describe clusters of patients, in...
Source: Acta Oncologica - August 31, 2018 Category: Cancer & Oncology Authors: Christensen NL, Kejs AMT, Jakobsen E, Dalton SO, Rasmussen TR Tags: Acta Oncol Source Type: research

Low proportion of unreported cervical treatments in the cancer registry of Norway between 1998 and 2013.
CONCLUSIONS: CRN holds accurate information on cervical treatments. Completeness and particularly validity can be further improved through the establishment of new internal routines and regular linkage to hospital discharges. PMID: 30169991 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - August 31, 2018 Category: Cancer & Oncology Authors: Leinonen MK, Hansen SA, Skare GB, Skaaret IB, Silva M, Johannesen TB, Nygård M Tags: Acta Oncol Source Type: research

Local recurrence rate in a national Danish patient cohort after curative treatment for rectal cancer.
CONCLUSIONS: Five-year follow-up of curatively treated patients with RC in Denmark revealed a low LRR. This figure is identical to those reported in other Nordic countries, despite Denmark's considerably stricter guidelines for CRT. The obtained results justify the currently adopted restrictive use of preoperative CRT in Denmark. PMID: 30169998 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - August 31, 2018 Category: Cancer & Oncology Authors: Poulsen LØ, Yilmaz MK, Ljungmann K, Jespersen N, Wille-Jørgensen P, Petersen LN, Falkmer UG, Danish Colorectal Cancer Group (DCCG.DK) Tags: Acta Oncol Source Type: research

Causes for delay before specialist consultation in head and neck cancer.
CONCLUSIONS: Although most patients sought medical advice without a major delay and were adequately referred, we found that long delays existed. Raising awareness of the symptoms of head and neck cancer among general population and health-care providers is probably the best way to get patients to curative treatment without delay. PMID: 30141700 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - August 24, 2018 Category: Cancer & Oncology Authors: Nieminen M, Aro K, Jouhi L, Bäck L, Mäkitie A, Atula T Tags: Acta Oncol Source Type: research

Brain dosimetry from locally advanced head and neck cancer radiotherapy: implications for neurocognitive outcomes research.
PMID: 30141706 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - August 24, 2018 Category: Cancer & Oncology Authors: McDonald AM, Murdaugh DL, Milner D, Cardan RA, Bhatia S Tags: Acta Oncol Source Type: research

Heart sparing breast cancer radiotherapy using continuous positive airway pressure (CPAP) and conventional supine tangential fields: an alternative method for patients with limited accessibility to advanced radiotherapy techniques.
PMID: 30106320 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - August 14, 2018 Category: Cancer & Oncology Authors: Kil WJ, Pham T, Kim K Tags: Acta Oncol Source Type: research

Imatinib mesylate in the management of chemotherapy-induced pulmonary toxicity: a double-edged sword.
PMID: 30106325 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - August 14, 2018 Category: Cancer & Oncology Authors: Eskazan AE Tags: Acta Oncol Source Type: research

Unusual presentation of syncytial variant of nodular sclerosis classical Hodgkin's lymphoma presenting as unilateral lung mass in a 15-year-old child.
PMID: 30102114 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - August 13, 2018 Category: Cancer & Oncology Authors: Sachdev R, Goel S, Rastogi N, Yadav SP, Mohapatra I Tags: Acta Oncol Source Type: research

Efficacy and toxicity of eribulin treatment in metastatic breast cancer patients.
ST PMID: 30101626 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - August 11, 2018 Category: Cancer & Oncology Authors: Brems-Eskildsen AS, Kristoffersen KB, Linnet S, Lörincz T, Langkjer ST Tags: Acta Oncol Source Type: research

Antineoplastic treatment with crizotinib during pregnancy: a case report.
;hl M PMID: 30101631 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - August 11, 2018 Category: Cancer & Oncology Authors: Jensen KH, Persson G, Storgaard L, Nielsen BB, Pedersen BW, Maroun LL, Huitema A, Pøhl M Tags: Acta Oncol Source Type: research

Associations between hematologic toxicity and health-related quality of life during first-line chemotherapy in advanced non-small-cell lung cancer: a pooled analysis of two randomized trials.
CONCLUSIONS: Patients developing severe HT had worse changes in two out of four of the primary HRQoL endpoints, but the association was not strong enough to use blood counts to identify patients who need more clinical attention and supportive care during chemotherapy. PMID: 30074418 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - August 3, 2018 Category: Cancer & Oncology Authors: Kristensen A, Solheim TS, Fløtten Ø, Grønberg BH Tags: Acta Oncol Source Type: research

Reproducibility of heart and thoracic wall position in repeated deep inspiration breath holds for radiotherapy of left-sided breast cancer patients.
CONCLUSIONS: The heart edge and thoracic wall reproducibility was high in relation to the medial heart displacement induced by the DIBH. PMID: 30074438 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - August 3, 2018 Category: Cancer & Oncology Authors: Wikström K, Isacsson U, Nilsson K, Ahnesjö A Tags: Acta Oncol Source Type: research

Pre-treatment CT radiomics to predict 3-year overall survival following chemoradiotherapy of esophageal cancer.
CONCLUSIONS: A RF model predicting 3-year overall survival based on pretreatment CT radiomic features was developed and validated in two independent datasets of esophageal cancer patients. The radiomics model had better prognostic power compared to the model using standard clinical variables. PMID: 30067421 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - August 1, 2018 Category: Cancer & Oncology Authors: Larue RTHM, Klaassen R, Jochems A, Leijenaar RTH, Hulshof MCCM, van Berge Henegouwen MI, Schreurs WMJ, Sosef MN, van Elmpt W, van Laarhoven HWM, Lambin P Tags: Acta Oncol Source Type: research

The survival outcome of patients with metastatic colorectal cancer based on the site of metastases and the impact of molecular markers and site of primary cancer on metastatic pattern.
Abstract BACKGROUND: Pattern of spread in patients with metastatic colorectal cancer (mCRC) is variable and may reflect different biology in subsets of patients. This is a retrospective study to explore the outcome of patients with mCRC based on their site of metastasis at diagnosis and to explore the association between tumor characteristics [KRAS/RAS, BRAF, mismatch repair (MMR) status, site of primary] and the site of metastasis. METHODS: Patients from two Australian databases were divided into six groups based on site of metastasis at time of diagnosis of metastatic disease; lung-only, liver-only, lymph n...
Source: Acta Oncologica - July 23, 2018 Category: Cancer & Oncology Authors: Prasanna T, Karapetis CS, Roder D, Tie J, Padbury R, Price T, Wong R, Shapiro J, Nott L, Lee M, Chua YJ, Craft P, Piantadosi C, Sorich M, Gibbs P, Yip D Tags: Acta Oncol Source Type: research

Initial report of the genitourinary and gastrointestinal toxicity of post-prostatectomy proton therapy for prostate cancer patients undergoing adjuvant or salvage radiotherapy.
Abstract PURPOSE: To report acute and late genitourinary (GU) and gastrointestinal (GI) toxicities associated with post-prostatectomy proton therapy (PT). METHODS: The first 100 consecutive patients from 2010 to 2016 were retrospectively assessed. Baseline characteristics, prospectively graded CTCAE v4.0 toxicities, and patient-reported outcomes were reported. Late outcomes were reported for 79 patients with 3 months minimum follow up. Toxicity-free survival Kaplan-Meier curves were estimated. Logistic regression assessed associations between toxicities and clinical and treatment characteristics (p 
Source: Acta Oncologica - July 20, 2018 Category: Cancer & Oncology Authors: Deville C, Jain A, Hwang WT, Woodhouse KD, Both S, Wang S, Gabriel PE, Christodouleas JP, Bekelman J, Tochner Z, Vapiwala N Tags: Acta Oncol Source Type: research